MCID: RNL077
MIFTS: 49

Renal Fibrosis

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

MalaCards integrated aliases for Renal Fibrosis:

Name: Renal Fibrosis 12 55 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855
UMLS 72 C0151650

Summaries for Renal Fibrosis

Disease Ontology : 12 A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function.

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and iga glomerulonephritis. An important gene associated with Renal Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Spironolactone and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 ureteral obstruction 31.7 TGFB1 BMP7 BMP6 AGTR1
2 iga glomerulonephritis 30.4 TGFB1 REN CCL2 AGTR1
3 idiopathic interstitial pneumonia 30.4 TGFB1 SERPINE1 CCN2 CCL2
4 obstructive nephropathy 30.1 TGFB1 SMAD3 SMAD2 REN HGF
5 nephrosclerosis 30.0 TGFB1 NR3C2 CCL2 AGTR1
6 pulmonary fibrosis 29.8 TGFB1 SMAD7 SMAD3 CCN2 CCL2
7 kidney disease 29.6 TGFB1 SERPINE1 REN NR3C2 CCN2 CCL2
8 autosomal dominant polycystic kidney disease 29.6 REN KL CDH1 CCL2
9 vascular disease 29.3 SERPINE1 REN CCL2 BMP6
10 hypertension, essential 29.2 SERPINE1 REN NR3C2 AGTR1
11 hypertrophic scars 29.1 TGFB1 SMAD3 SMAD2 CD36 BMP6
12 urinary tract obstruction 28.5 TGFB1 SMAD7 SMAD3 SMAD2 REN CDH1
13 pulmonary fibrosis, idiopathic 27.3 TGFB1 SMAD3 SMAD2 HGF CDH1 CD36
14 nephronophthisis 20 11.1
15 fibrosis of extraocular muscles, congenital, 1 11.0
16 chronic kidney disease 10.8
17 microvascular complications of diabetes 3 10.6
18 microvascular complications of diabetes 4 10.6
19 microvascular complications of diabetes 6 10.6
20 microvascular complications of diabetes 7 10.6
21 end stage renal failure 10.6
22 malignant renovascular hypertension 10.5 SERPINE1 REN
23 malignant hypertensive renal disease 10.5 SERPINE1 REN
24 glomerulonephritis 10.3
25 ocular cicatricial pemphigoid 10.3 TGFB1 CD36 CCN2
26 pauci-immune glomerulonephritis 10.3 SMAD2 CCN2 BMP7
27 fibromuscular dysplasia 10.3 TGFB1 REN AGTR1
28 heart valve disease 10.3 TGFB1 REN NR3C2
29 respiratory system disease 10.3 TGFB1 CDH1 CCL2
30 spastic paraplegia 3, autosomal dominant 10.3 TGFB1 SMAD2 CDH1
31 spondylocarpotarsal synostosis syndrome 10.3 SMAD3 SMAD2 CCN2
32 central serous chorioretinopathy 10.3 SERPINE1 NR3C2
33 gingival overgrowth 10.3 TGFB1 CD36 CCN2
34 systemic lupus erythematosus 10.2
35 ischemia 10.2
36 anuria 10.2 REN NR3C2 AGTR1
37 malignant secondary hypertension 10.2 SERPINE1 REN
38 familial hypertension 10.2 REN NR3C2 AGTR1
39 acquired metabolic disease 10.1 SERPINE1 REN CCL2
40 nephrotic syndrome 10.1
41 chagas disease 10.1 TGFB1 SMAD2 CCL2
42 alport syndrome 10.1
43 hyperglycemia 10.1
44 hypoxia 10.1
45 hypertensive heart disease 10.1 NR3C2 CD36 AGTR1
46 arthrogryposis, distal, type 3 10.1 REN NR3C2
47 vitreoretinopathy, neovascular inflammatory 10.0 TGFB1 HGF CCL2
48 peyronie's disease 10.0 TGFB1 SMAD7 SMAD3 CCL2
49 hypertensive nephropathy 10.0
50 hypochondrogenesis 10.0 SMAD7 SMAD3 SMAD2

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

GenomeRNAi Phenotypes related to Renal Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AGTR1 CCL2 CDH1 MAPK8 NR3C2 RGCC

MGI Mouse Phenotypes related to Renal Fibrosis:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.51 AGTR1 BMP7 CCN2 CD36 CDH1 HGF
2 growth/size/body region MP:0005378 10.45 AGTR1 BMP6 BMP7 CCN2 CD36 CDH1
3 hematopoietic system MP:0005397 10.36 AGTR1 BMP7 CD36 HGF KL MAPK8
4 cellular MP:0005384 10.35 CCN2 CD36 CDH1 HGF KL MAPK8
5 homeostasis/metabolism MP:0005376 10.34 AGTR1 CCN2 CD36 CDH1 KL MAPK8
6 behavior/neurological MP:0005386 10.33 AGTR1 BMP7 CD36 KL MAPK8 NR3C2
7 mortality/aging MP:0010768 10.33 AGTR1 BMP7 CCN2 CD36 CDH1 HGF
8 immune system MP:0005387 10.32 AGTR1 BMP7 CCL2 CD36 CDH1 KL
9 embryo MP:0005380 10.29 BMP7 CCN2 CDH1 HGF MAPK8 RGCC
10 endocrine/exocrine gland MP:0005379 10.28 BMP7 CCN2 CD36 CDH1 KL MAPK8
11 digestive/alimentary MP:0005381 10.26 BMP7 CCN2 CD36 CDH1 KL MAPK8
12 craniofacial MP:0005382 10.17 BMP7 CCN2 KL MAPK8 SMAD2 SMAD3
13 integument MP:0010771 10.16 BMP7 CCN2 CDH1 KL MAPK8 SERPINE1
14 liver/biliary system MP:0005370 10.09 CCN2 CD36 HGF KL MAPK8 SERPINE1
15 adipose tissue MP:0005375 10.08 AGTR1 CD36 KL MAPK8 SERPINE1 TGFB1
16 nervous system MP:0003631 10.06 AGTR1 BMP7 CD36 KL MAPK8 NR3C2
17 muscle MP:0005369 9.97 CD36 KL MAPK8 NR3C2 REN SMAD7
18 renal/urinary system MP:0005367 9.96 AGTR1 BMP7 CD36 KL MAPK8 NR3C2
19 reproductive system MP:0005389 9.85 BMP6 BMP7 CDH1 KL MAPK8 REN
20 respiratory system MP:0005388 9.5 BMP7 CCN2 KL MAPK8 SERPINE1 SMAD2
21 vision/eye MP:0005391 9.23 BMP7 CCN2 CD36 KL MAPK8 SMAD2

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
3
Sirolimus Approved, Investigational Phase 4 53123-88-9 6436030 5284616 46835353
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
7
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
8
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
9
rituximab Approved Phase 4 174722-31-7 10201696
10 Anti-Bacterial Agents Phase 4
11 Anti-Infective Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Calcineurin Inhibitors Phase 4
14 Diuretics, Potassium Sparing Phase 4
15 diuretics Phase 4
16 Hormones Phase 4
17 Mineralocorticoid Receptor Antagonists Phase 4
18 Mineralocorticoids Phase 4
19 Natriuretic Agents Phase 4
20 Hormone Antagonists Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
22 Antifungal Agents Phase 4
23 Antitubercular Agents Phase 4
24 Immunosuppressive Agents Phase 4
25 Antibiotics, Antitubercular Phase 4
26 Angiotensinogen Phase 4
27 Giapreza Phase 4
28 Angiotensin-Converting Enzyme Inhibitors Phase 4
29 Omega 3 Fatty Acid Phase 4
30 Antibodies Phase 4
31 Immunologic Factors Phase 4
32 Antineoplastic Agents, Immunological Phase 4
33 Immunoglobulins Phase 4
34 Vasoconstrictor Agents Phase 4
35 Immunoglobulin A Phase 4
36 Antirheumatic Agents Phase 4
37
Eplerenone Approved Phase 3 107724-20-9 150310 443872
38
Ramipril Approved Phase 3 87333-19-5 5362129
39 Antihypertensive Agents Phase 3
40 HIV Protease Inhibitors Phase 3
41
protease inhibitors Phase 3
42
Losartan Approved Phase 2 114798-26-4 3961
43
Benazepril Approved, Investigational Phase 2 86541-75-5 5362124
44
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
45
Lisinopril Approved, Investigational Phase 2 83915-83-7, 76547-98-3 5362119
46
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
47
Adalimumab Approved Phase 2 331731-18-1 16219006
48
Atorvastatin Approved Phase 2 134523-00-5 60823
49 Angiotensin II Type 1 Receptor Blockers Phase 2
50 Angiotensin Receptor Antagonists Phase 2

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity Unknown status NCT01602861 Phase 4 Spironolactone;placebo
2 Impact of a Mineralocorticoid Receptor Antagonist on Chronic Histological Changes in Renal Allograft Unknown status NCT01510795 Phase 4 spironolactone
3 Phase 4 Study: Comparison of Myfortic and Early Rapamycin Conversion vs. Low-Dose Tacrolimus in Preventing Acute Rejection and Chronic Allograft Fibrosis: A Protocol Biopsy Directed Approach Unknown status NCT00896012 Phase 4 Rapamune (sirolimus/rapamycin);Tacrolimus
4 A Multicenter, Randomized, Prospective, Open-Label Trial of Rituximab in the Treatment of Progressive IgA Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
5 Prospective and Open Label Study With Blind End Point Evaluation on the Effect of Mineralocorticoid Receptor Inhibition on Endothelial Function of the Micro- and Macrovasculature in Patients With Metabolic Syndrome Completed NCT01319344 Phase 3 Eplerenone
6 Early Prospective Therapy Trial to Delay Renal Failure in Children With Alport Syndrome Active, not recruiting NCT01485978 Phase 3 Ramipril;placebo to ramipril;Ramipril
7 Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure. A Proof of Concept Clinical Trial Within the EU FP 7 (European Union FP7) "HOMAGE" Programme " Heart OMics in AGing " Completed NCT02556450 Phase 2 Spironolacton
8 Effects of an Intensified Treatment With ACE-inhibitors, Angiotensin II Receptor Antagonists and Statins in Alport Syndrome Completed NCT00309257 Phase 2 ACE I, ATA II and Statins;Benazepril, Valsartan and Fluvastatin
9 Novel Therapies for Resistant Focal Segmental Glomerulosclerosis Completed NCT00814255 Phase 2 Adalimumab;Lisinopril, losartan, and atorvastatin;galactose
10 Phase III, Single-Center, Open Label, Trial Evaluating the Safety and Efficacy of PectaSol-C Modified Citrus Pectin on PSA Kinetics in Prostate Cancer in the Setting of Serial Increases in PSA Recruiting NCT01681823 Phase 2
11 A Trial of Doxycycline in Renal Disease (ADORE) Active, not recruiting NCT02753426 Phase 1 Doxycycline;Placebo (for Doxycycline)
12 Interest Of Renal Elastography In Children As A Diagnostic Tool Of Renal Fibrosis: Confrontation To Histological Features Of Renal Biopsies Unknown status NCT01613625
13 Study of Urinary Angiotensinogen as a Marker to Warn the Deterioration of Renal Function in CKD Patients Early. Unknown status NCT01118494
14 The Effect of Percutaneous Nephrostomy Application on Obstructed Kidneys With Relative Function of 10% or Less In Technetium-99m Dimercaptosuccinic Acid (DMSA) Scintigraphy Completed NCT03936673
15 Prospective Multicenter Study to Assess the Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery During Acute Tubular Necrosis Completed NCT02889575
16 Non-invasive Diagnosis of Chronic Kidney Disease in Renal Transplants Kidney Transplanted Using Ultrasound Functional Imaging Completed NCT02201537
17 Evaluation of the Effects of a Probiotic Formulation in Hemodialysis Patients Completed NCT03066921
18 Kidney Disease Biomarkers Completed NCT00255398
19 Angiotensin II Antagonism of TGF-Beta 1: A Candesartan Dose - TGF-Beta 1 Response Relationship Study Completed NCT00320970 Candesartan
20 Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study Completed NCT01696253
21 Application of Ultrasound Integrated Precision Diagnosis Technology in Prevention of Kidney Disease and Its Progress Recruiting NCT04044404
22 Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy? Recruiting NCT02768948 telmisartan during 6 months;Losartan during 6 months
23 Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM) Recruiting NCT03918161
24 A Randomised Controlled Trial of the Effect of Dietary Salt Reduction on Blood Pressure and Other Cardiovascular Parameters in Kidney Transplant Recipients Recruiting NCT03373500
25 The Role of Nox2 in CNI-Induced Renal Fibrosis Active, not recruiting NCT01674465
26 Multicenter, Prospective Observational Study to Identify and Validate a Composite of Urinary Exosomal Biomarkers for Kidney Allograft Tubulointerstitial Fibrosis Not yet recruiting NCT03870542

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

41
Kidney, Endothelial, Bone, T Cells, Monocytes, Heart, Liver

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 3659)
# Title Authors PMID Year
1
Lefty A attenuates the TGF-beta1-induced epithelial to mesenchymal transition of human renal proximal epithelial tubular cells. 9 38
20157767 2010
2
Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. 9 38
20237235 2010
3
Oxidative stress mediates nephropathy in type Ia glycogen storage disease. 9 38
20195241 2010
4
EMT and TGF-beta in renal fibrosis. 9 38
20036943 2010
5
Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis. 9 38
19955828 2010
6
Hepatocyte growth factor suppresses transforming growth factor-beta-1 and type III collagen in human primary renal fibroblasts. 9 38
19858036 2009
7
Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. 9 38
19741012 2009
8
Sphingosine kinase-1: a potential mediator of renal fibrosis. 9 38
19789541 2009
9
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. 9 38
19657322 2009
10
IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis. 9 38
19536084 2009
11
CTGF and chronic kidney fibrosis. 9 38
19482689 2009
12
[Molecular mechanisms of tissue fibrosis]. 9 38
19564712 2009
13
Mitogen activated protein kinases in renal fibrosis. 9 38
19482693 2009
14
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. 9 38
19557718 2009
15
Transforming growth factor-beta1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up. 9 38
19538767 2009
16
Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp. 9 38
19223201 2009
17
[Dracorhodin perchlorate inhibit high glucose-induced connective tissue growth factor formation in human mesangial cells]. 9 38
19623991 2009
18
Prediction of chronic allograft damage index of renal allografts using serum level of plasminogen activator inhibitor-1. 9 38
19220364 2009
19
Relaxin and the progression of kidney disease. 9 38
19077683 2009
20
Transforming growth factor beta and excess burden of renal disease. 9 38
19768163 2009
21
EPA and DHA suppress AngII- and arachidonic acid-induced expression of profibrotic genes in human mesangial cells. 9 38
19229829 2009
22
Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction. 9 38
18818685 2009
23
Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells. 9 38
19034873 2008
24
Bone morphogenetic protein-7 and connective tissue growth factor: novel targets for treatment of renal fibrosis? 9 38
18266088 2008
25
Impact of plasminogen activator inhibitor-1 gene polymorphisms on primary membranous nephropathy. 9 38
18495745 2008
26
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. 9 38
18509316 2008
27
IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. 9 38
18508967 2008
28
Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. 9 38
18446379 2008
29
A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. 9 38
18367541 2008
30
Tissue inhibitor of metalloproteinase-1 exacerbated renal interstitial fibrosis through enhancing inflammation. 9 38
18326884 2008
31
Smad7 as a therapeutic agent for chronic kidney diseases. 9 38
18508563 2008
32
Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. 9 38
18376005 2008
33
The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. 9 38
18327089 2008
34
Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells. 9 38
17989112 2008
35
A new look at platelet-derived growth factor in renal disease. 9 38
18077793 2008
36
BMP-7 does not protect against bleomycin-induced lung or skin fibrosis. 9 38
19112509 2008
37
Transforming growth factor-beta/connective tissue growth factor axis in the kidney. 9 38
17300978 2008
38
Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. 9 38
17274978 2007
39
Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells. 9 38
17498677 2007
40
TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis. 9 38
17376761 2007
41
Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease. 9 38
17415547 2007
42
Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation. 9 38
17400544 2007
43
Functional renin receptors in renal mesangial cells. 9 38
17442225 2007
44
TGF-beta1 in chronic allograft nephropathy following renal transplantation. 9 38
17514622 2007
45
Role of connective tissue growth factor in extracellular matrix degradation in renal tubular epithelial cells. 9 38
17393107 2007
46
The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. 9 38
17347580 2007
47
Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells. 9 38
17113706 2007
48
TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice. 9 38
17167153 2006
49
Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. 9 38
16914537 2006
50
HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms. 9 38
16710352 2006

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TGFB1 SMAD3 SMAD2 MAPK8 HGF CDH1
2
Show member pathways
13.49 TGFB1 SMAD7 SMAD3 SMAD2 MAPK8 HGF
3
Show member pathways
13.41 TGFB1 MAPK8 HGF CCN2 CCL2 BMP7
4
Show member pathways
13.33 TGFB1 SMAD3 MAPK8 HGF CDH1 CCN2
5
Show member pathways
13.28 TGFB1 MAPK8 HGF CDH1 CCN2 BMP7
6
Show member pathways
13.1 TGFB1 SMAD3 SMAD2 SERPINE1 MAPK8 CCL2
7
Show member pathways
13.06 TGFB1 REN MAPK8 HGF CCN2 CCL2
8 12.88 TGFB1 SMAD3 SMAD2 MAPK8 HGF CDH1
9
Show member pathways
12.86 TGFB1 SMAD3 SMAD2 MAPK8 CDH1
10
Show member pathways
12.77 TGFB1 SMAD3 SMAD2 HGF CDH1
11
Show member pathways
12.71 TGFB1 HGF CCN2 BMP7 BMP6
12
Show member pathways
12.5 TGFB1 SPHK1 SMAD3 SMAD2 BMP7
13
Show member pathways
12.43 TGFB1 MAPK8 HGF CDH1 CCN2 BMP7
14 12.37 TGFB1 SMAD3 SMAD2 CDH1
15 12.36 TGFB1 SMAD3 SMAD2 MAPK8
16
Show member pathways
12.34 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
17
Show member pathways
12.28 TGFB1 HGF CCN2 BMP7 BMP6
18 12.24 TGFB1 SMAD3 SMAD2 SERPINE1 CCN2 BMP7
19
Show member pathways
12.23 TGFB1 SMAD3 SMAD2 MAPK8
20 12.19 TGFB1 SMAD3 SMAD2 CDH1
21 12.18 TGFB1 SMAD3 SMAD2 SERPINE1
22 12.12 TGFB1 SMAD7 SMAD3 SMAD2 MAPK8
23 12.11 TGFB1 SMAD3 SMAD2 MAPK8 BMP7 BMP6
24
Show member pathways
12.1 TGFB1 SMAD3 SMAD2 MAPK8
25 12.05 SPHK1 SMAD3 SMAD2 SERPINE1 CDH1 CCN2
26 12.01 TGFB1 HGF CD36 CCL2
27 11.96 TGFB1 SMAD7 SMAD3 SMAD2 MAPK8
28 11.9 TGFB1 REN HGF CCL2
29
Show member pathways
11.86 TGFB1 SMAD3 SMAD2
30 11.85 TGFB1 SMAD7 SMAD3 SMAD2 BMP7 BMP6
31 11.83 SMAD7 SMAD3 SMAD2 SERPINE1
32
Show member pathways
11.82 TGFB1 SMAD3 SMAD2 MAPK8
33 11.8 TGFB1 SMAD3 SMAD2 SERPINE1 MAPK8 CCL2
34 11.8 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1 CDH1
35 11.79 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
36
Show member pathways
11.77 TGFB1 SMAD7 SMAD3 SMAD2
37 11.77 TGFB1 SMAD3 SMAD2 MAPK8 BMP7 BMP6
38 11.75 TGFB1 HGF CCN2 BMP7 BMP6
39
Show member pathways
11.74 SMAD7 BMP7 BMP6
40 11.73 SMAD3 SMAD2 CDH1
41 11.73 TGFB1 CD36 CCL2
42 11.69 SMAD3 SMAD2 MAPK8
43 11.68 TGFB1 BMP7 BMP6
44 11.66 TGFB1 SMAD7 SMAD3 SMAD2 SERPINE1
45
Show member pathways
11.65 TGFB1 SMAD3 SMAD2 MAPK8
46 11.6 TGFB1 HGF CD36 CCL2
47 11.6 TGFB1 SMAD7 HGF CCN2 CCL2 BMP7
48 11.56 TGFB1 SMAD3 MAPK8
49 11.56 TGFB1 SMAD7 SMAD3 SMAD2 CCN2
50
Show member pathways
11.38 TGFB1 SMAD7 SMAD3 SMAD2 MAPK8 HGF

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 TGFB1 SERPINE1 REN KL HGF CDH1
2 platelet alpha granule lumen GO:0031093 9.54 TGFB1 SERPINE1 HGF
3 SMAD protein complex GO:0071141 9.32 SMAD3 SMAD2
4 extracellular space GO:0005615 9.32 TGFB1 SERPINE1 REN KL HGF CD36
5 heteromeric SMAD protein complex GO:0071144 9.16 SMAD3 SMAD2
6 intracellular GO:0005622 9.13 SMAD7 SMAD3 SMAD2

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 TGFB1 KL HGF CCL2
2 cellular response to lipopolysaccharide GO:0071222 9.95 SERPINE1 MAPK8 CD36 CCL2
3 platelet degranulation GO:0002576 9.92 TGFB1 SERPINE1 HGF CD36
4 wound healing GO:0042060 9.91 TGFB1 SMAD3 SMAD2
5 response to organic substance GO:0010033 9.9 TGFB1 REN CDH1
6 ossification GO:0001503 9.9 CCN2 BMP7 BMP6
7 kidney development GO:0001822 9.9 REN BMP7 BMP6 AGTR1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 TGFB1 HGF CD36
9 cell chemotaxis GO:0060326 9.89 HGF CCL2 AGTR1
10 BMP signaling pathway GO:0030509 9.89 SMAD7 BMP7 BMP6
11 cellular response to mechanical stimulus GO:0071260 9.88 TGFB1 MAPK8 BMP6
12 response to glucose GO:0009749 9.87 TGFB1 SMAD2 CCN2
13 transforming growth factor beta receptor signaling pathway GO:0007179 9.86 TGFB1 SMAD7 SMAD3 SMAD2
14 positive regulation of gene expression GO:0010628 9.86 TGFB1 SMAD3 SMAD2 RGCC MAPK8 CD36
15 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 TGFB1 SMAD7 SMAD3
16 positive regulation of osteoblast differentiation GO:0045669 9.84 HGF BMP7 BMP6
17 cell development GO:0048468 9.83 TGFB1 BMP7 BMP6
18 positive regulation of stress fiber assembly GO:0051496 9.83 SMAD3 RGCC CCN2
19 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 TGFB1 SMAD7 SMAD3 SMAD2
20 positive regulation of cell death GO:0010942 9.82 CD36 CCN2 BMP7
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 TGFB1 BMP7 BMP6
22 regulation of MAPK cascade GO:0043408 9.81 TGFB1 REN BMP7 BMP6
23 epithelial to mesenchymal transition GO:0001837 9.8 TGFB1 HGF BMP7
24 positive regulation of protein import into nucleus GO:0042307 9.79 TGFB1 SMAD3 CDH1
25 mesoderm formation GO:0001707 9.78 SMAD3 SMAD2 BMP7
26 endoderm development GO:0007492 9.77 TGFB1 SMAD3 SMAD2
27 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.76 TGFB1 SPHK1 BMP7
28 positive regulation of DNA biosynthetic process GO:2000573 9.74 RGCC HGF
29 negative regulation of cell-cell adhesion GO:0022408 9.73 TGFB1 CDH1
30 negative regulation of wound healing GO:0061045 9.73 SMAD3 SERPINE1
31 positive regulation of blood coagulation GO:0030194 9.73 SERPINE1 CD36
32 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 TGFB1 SMAD7
33 mesonephros development GO:0001823 9.72 REN BMP7
34 lens fiber cell differentiation GO:0070306 9.72 TGFB1 SMAD3
35 positive regulation of collagen biosynthetic process GO:0032967 9.72 TGFB1 RGCC CCN2
36 SMAD protein signal transduction GO:0060395 9.72 TGFB1 SMAD3 SMAD2 BMP7 BMP6
37 positive regulation of SMAD protein signal transduction GO:0060391 9.71 TGFB1 BMP6
38 embryonic pattern specification GO:0009880 9.71 SMAD3 SMAD2 BMP7
39 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.71 TGFB1 SMAD7 SMAD3 SMAD2
40 salivary gland morphogenesis GO:0007435 9.7 TGFB1 BMP7
41 response to cholesterol GO:0070723 9.7 TGFB1 SMAD2
42 primary miRNA processing GO:0031053 9.7 SMAD3 SMAD2
43 nodal signaling pathway GO:0038092 9.69 SMAD3 SMAD2
44 pericardium development GO:0060039 9.68 SMAD3 SMAD2
45 embryonic foregut morphogenesis GO:0048617 9.68 SMAD3 SMAD2
46 response to laminar fluid shear stress GO:0034616 9.67 TGFB1 SMAD7
47 regulation of removal of superoxide radicals GO:2000121 9.67 CD36 BMP7
48 common-partner SMAD protein phosphorylation GO:0007182 9.65 TGFB1 SMAD2
49 SMAD protein complex assembly GO:0007183 9.65 TGFB1 SMAD3 SMAD2
50 renin-angiotensin regulation of aldosterone production GO:0002018 9.63 REN AGTR1

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.85 TGFB1 SMAD3 SMAD2 HGF BMP6 AGTR1
2 cytokine activity GO:0005125 9.76 TGFB1 CCL2 BMP7 BMP6
3 beta-catenin binding GO:0008013 9.69 SMAD7 SMAD3 CDH1
4 growth factor activity GO:0008083 9.55 TGFB1 HGF CCN2 BMP7 BMP6
5 enhancer binding GO:0035326 9.54 SMAD3 SMAD2
6 co-SMAD binding GO:0070410 9.52 SMAD3 SMAD2
7 I-SMAD binding GO:0070411 9.49 SMAD7 SMAD2
8 BMP receptor binding GO:0070700 9.48 BMP7 BMP6
9 primary miRNA binding GO:0070878 9.43 SMAD3 SMAD2
10 R-SMAD binding GO:0070412 9.43 SMAD3 SMAD2 RGCC
11 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD3 SMAD2
12 type I transforming growth factor beta receptor binding GO:0034713 9.13 TGFB1 SMAD7 SMAD2
13 transforming growth factor beta receptor binding GO:0005160 9.02 TGFB1 SMAD3 SMAD2 BMP7 BMP6
14 protein binding GO:0005515 10.28 THG1L TGFB1 SPHK1 SMAD7 SMAD3 SMAD2

Sources for Renal Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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