MCID: RNL077
MIFTS: 46

Renal Fibrosis

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

MalaCards integrated aliases for Renal Fibrosis:

Name: Renal Fibrosis 12 54 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855
UMLS 70 C0151650

Summaries for Renal Fibrosis

Disease Ontology : 12 A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function.

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and obstructive nephropathy. An important gene associated with Renal Fibrosis is CCN2 (Cellular Communication Network Factor 2), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Ramipril and Angiotensin-Converting Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone marrow, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 ureteral obstruction 31.9 TGFB1 NR3C2 ENG BMP7 BMP6 AGTR1
2 obstructive nephropathy 31.6 TGFB1 SMAD3 REN
3 microvascular complications of diabetes 3 31.6 TGFB1 REN MIR21 CCN2 BMP6 AGTR1
4 end stage renal disease 31.4 TGFB1 REN CCL2 AGTR1
5 chronic kidney disease 31.2 TGFB1 SERPINE1 REN NR3C2 MIR21 CCN2
6 glomerulonephritis 31.2 TGFB1 CCN2 CCL2 AGTR1
7 iga glomerulonephritis 30.9 TGFB1 REN CCL2 AGTR1
8 kidney disease 30.9 TGFB1 SERPINE1 REN NR3C2 MIR21 CCN2
9 pulmonary fibrosis 30.7 TGFB1 SMAD3 SERPINE1 CCN2 CCL2 BMP6
10 hydronephrosis 30.5 TGFB1 REN HIF1A CCL2
11 crescentic glomerulonephritis 30.5 SERPINE1 CCN2 CCL2
12 urinary tract obstruction 30.4 TGFB1 SMAD3 SERPINE1 REN CDH1 CCN2
13 polycystic kidney disease 30.4 TGFB1 REN HIF1A CDH1 CCN2 CCL2
14 hypertrophic scars 30.3 TGFB1 SMAD3 BMP6
15 nephrosclerosis 30.3 TGFB1 NR3C2 HIF1A CCN2 CCL2 BMP7
16 renal hypertension 30.2 REN NR3C2 MIR200B AGTR1
17 telangiectasis 30.2 TGFBR1 ENG BMP6
18 autosomal dominant polycystic kidney disease 30.1 TGFB1 REN CDH1 CCL2 AGTR1
19 limb ischemia 30.1 SERPINE1 MIR21 HIF1A CCL2
20 acute cystitis 30.1 REN NR3C2 CCL2
21 focal segmental glomerulosclerosis 30.1 TGFB1 SMAD3 CCL2 AGTR1
22 arteriosclerosis 30.0 SERPINE1 MIR21 HIF1A CCL2
23 vesicoureteral reflux 1 30.0 TGFB1 REN AGTR1
24 posterior urethral valves 30.0 TGFB1 AGTR1
25 diabetes mellitus 30.0 TGFB1 SMAD3 SERPINE1 REN NR3C2 MAPK8
26 vascular disease 29.8 TGFB1 SERPINE1 REN MIR21 ENG CCL2
27 connective tissue disease 29.8 TGFBR1 SMAD3 MIR21 MIR200B CCN2 CCL2
28 type 2 diabetes mellitus 29.8 TGFB1 SERPINE1 REN MAPK8 HIF1A CCN2
29 pulmonary fibrosis, idiopathic 29.8 TGFBR1 TGFB1 SMAD3 SERPINE1 MIR21 HIF1A
30 heart disease 29.7 TGFB1 SERPINE1 REN NR3C2 MIR21 HIF1A
31 myocardial infarction 29.4 TGFB1 SERPINE1 REN NR3C2 MIR21 HIF1A
32 hypertension, essential 29.4 TGFB1 SMAD3 SERPINE1 REN NR3C2 MIR21
33 fibrosis of extraocular muscles, congenital, 1 11.2
34 nephronophthisis 20 10.9
35 microvascular complications of diabetes 4 10.8
36 microvascular complications of diabetes 6 10.8
37 microvascular complications of diabetes 7 10.8
38 proteinuria, chronic benign 10.6
39 pauci-immune glomerulonephritis 10.5 CCN2 BMP7
40 urethral stricture 10.5 TGFB1 MIR21 CCN2
41 nephrogenic systemic fibrosis 10.5 TGFB1 SMAD3 CCN2
42 keloid disorder 10.5 TGFB1 BMP6
43 cholecystolithiasis 10.5 TGFB1 CCN2 BMP6
44 fibrosclerosis of breast 10.5 ENG CCN2
45 trachoma 10.5 TGFB1 ENG CCN2
46 spastic paraplegia 3, autosomal dominant 10.5 SMAD3 CDH1 CCN2
47 ischemia 10.4
48 peyronie's disease 10.4 TGFB1 SMAD3 CCL2
49 localized scleroderma 10.4 TGFB1 SMAD3 CCN2 BMP6
50 nonspecific interstitial pneumonia 10.4 TGFB1 MIR21 CCL2

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

GenomeRNAi Phenotypes related to Renal Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AGTR1 CCL2 CDH1 MAPK8 NR3C2 RGCC

MGI Mouse Phenotypes related to Renal Fibrosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 AGTR1 BMP7 CCN2 CDH1 ENG HIF1A
2 growth/size/body region MP:0005378 10.35 AGTR1 BMP6 BMP7 CCN2 CDH1 ENG
3 homeostasis/metabolism MP:0005376 10.28 AGTR1 BMP7 CCN2 CDH1 ENG HIF1A
4 hematopoietic system MP:0005397 10.27 AGTR1 BMP7 ENG HIF1A MAPK8 NR3C2
5 embryo MP:0005380 10.25 BMP7 CCN2 CDH1 ENG HIF1A MAPK8
6 digestive/alimentary MP:0005381 10.22 BMP7 CCN2 CDH1 ENG HIF1A MAPK8
7 immune system MP:0005387 10.22 AGTR1 BMP7 CCL2 CDH1 HIF1A MAPK8
8 mortality/aging MP:0010768 10.22 AGTR1 BMP7 CCN2 CDH1 ENG HIF1A
9 endocrine/exocrine gland MP:0005379 10.19 BMP7 CCN2 CDH1 HIF1A MAPK8 RGCC
10 integument MP:0010771 10.07 BMP7 CCN2 CDH1 ENG HIF1A MAPK8
11 muscle MP:0005369 9.86 ENG HIF1A MAPK8 NR3C2 REN SPHK1
12 neoplasm MP:0002006 9.7 CDH1 HIF1A MAPK8 SERPINE1 SMAD3 TGFB1
13 renal/urinary system MP:0005367 9.61 AGTR1 BMP7 HIF1A MAPK8 NR3C2 REN
14 respiratory system MP:0005388 9.23 BMP7 CCN2 ENG HIF1A MAPK8 SERPINE1

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 3 87333-19-5 5362129
2 Angiotensin-Converting Enzyme Inhibitors Phase 3
3
protease inhibitors Phase 3
4 Antihypertensive Agents Phase 3
5 HIV Protease Inhibitors Phase 3
6 Pharmaceutical Solutions
7 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Prospective Therapy Trial to Delay Renal Failure in Children With Alport Syndrome Completed NCT01485978 Phase 3 Ramipril;placebo to ramipril;Ramipril
2 Interest Of Renal Elastography In Children As A Diagnostic Tool Of Renal Fibrosis: Confrontation To Histological Features Of Renal Biopsies Unknown status NCT01613625
3 The Role of Nox2 in CNI-Induced Renal Fibrosis Completed NCT01674465
4 Multicenter, Prospective Observational Study to Identify and Validate a Composite of Urinary Exosomal Biomarkers for Kidney Allograft Tubulointerstitial Fibrosis Recruiting NCT03870542
5 Quantitative Magnetization Transfer MRI for Evaluation of Renal Fibrosis Not yet recruiting NCT04508049
6 Detection of Renal Fibrosis and Prediction of Kidney Function Decline: The Role of MRI and Markers of Accelerated Renal Ageing (MARS) Not yet recruiting NCT04625140

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

40
Kidney, Endothelial, Bone Marrow, Myeloid, T Cells, Smooth Muscle, Cortex

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 4477)
# Title Authors PMID Year
1
Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. 61 54
20237235 2010
2
Lefty A attenuates the TGF-beta1-induced epithelial to mesenchymal transition of human renal proximal epithelial tubular cells. 61 54
20157767 2010
3
Oxidative stress mediates nephropathy in type Ia glycogen storage disease. 54 61
20195241 2010
4
Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis. 54 61
19955828 2010
5
EMT and TGF-beta in renal fibrosis. 54 61
20036943 2010
6
Hepatocyte growth factor suppresses transforming growth factor-beta-1 and type III collagen in human primary renal fibroblasts. 61 54
19858036 2009
7
Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. 54 61
19741012 2009
8
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. 54 61
19657322 2009
9
Sphingosine kinase-1: a potential mediator of renal fibrosis. 61 54
19789541 2009
10
IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis. 54 61
19536084 2009
11
CTGF and chronic kidney fibrosis. 61 54
19482689 2009
12
[Molecular mechanisms of tissue fibrosis]. 61 54
19564712 2009
13
Mitogen activated protein kinases in renal fibrosis. 61 54
19482693 2009
14
Transforming growth factor-beta1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up. 54 61
19538767 2009
15
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. 61 54
19557718 2009
16
[Dracorhodin perchlorate inhibit high glucose-induced connective tissue growth factor formation in human mesangial cells]. 54 61
19623991 2009
17
Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp. 61 54
19223201 2009
18
Prediction of chronic allograft damage index of renal allografts using serum level of plasminogen activator inhibitor-1. 61 54
19220364 2009
19
Transforming growth factor beta and excess burden of renal disease. 61 54
19768163 2009
20
Relaxin and the progression of kidney disease. 54 61
19077683 2009
21
EPA and DHA suppress AngII- and arachidonic acid-induced expression of profibrotic genes in human mesangial cells. 61 54
19229829 2009
22
Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction. 61 54
18818685 2009
23
Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells. 54 61
19034873 2008
24
Impact of plasminogen activator inhibitor-1 gene polymorphisms on primary membranous nephropathy. 54 61
18495745 2008
25
Bone morphogenetic protein-7 and connective tissue growth factor: novel targets for treatment of renal fibrosis? 61 54
18266088 2008
26
IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. 61 54
18508967 2008
27
Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. 54 61
18446379 2008
28
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. 61 54
18509316 2008
29
A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. 61 54
18367541 2008
30
Tissue inhibitor of metalloproteinase-1 exacerbated renal interstitial fibrosis through enhancing inflammation. 61 54
18326884 2008
31
Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. 54 61
18376005 2008
32
Smad7 as a therapeutic agent for chronic kidney diseases. 61 54
18508563 2008
33
The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. 54 61
18327089 2008
34
Transforming growth factor-beta/connective tissue growth factor axis in the kidney. 54 61
17300978 2008
35
A new look at platelet-derived growth factor in renal disease. 54 61
18077793 2008
36
BMP-7 does not protect against bleomycin-induced lung or skin fibrosis. 61 54
19112509 2008
37
Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells. 54 61
17989112 2008
38
Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. 54 61
17274978 2007
39
Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells. 54 61
17498677 2007
40
TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis. 61 54
17376761 2007
41
Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease. 54 61
17415547 2007
42
Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation. 54 61
17400544 2007
43
Functional renin receptors in renal mesangial cells. 61 54
17442225 2007
44
TGF-beta1 in chronic allograft nephropathy following renal transplantation. 54 61
17514622 2007
45
Role of connective tissue growth factor in extracellular matrix degradation in renal tubular epithelial cells. 54 61
17393107 2007
46
Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells. 54 61
17113706 2007
47
The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. 54 61
17347580 2007
48
TIMP-1 promotes age-related renal fibrosis through upregulating ICAM-1 in human TIMP-1 transgenic mice. 54 61
17167153 2006
49
Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. 61 54
16914537 2006
50
HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms. 61 54
16710352 2006

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TGFBR1 TGFB1 SMAD3 MAPK8 HIF1A CDH1
2
Show member pathways
13.52 TGFBR1 TGFB1 SMAD3 MAPK8 CDH1 CCN2
3
Show member pathways
13.4 TGFBR1 TGFB1 MAPK8 CCN2 CCL2 BMP7
4
Show member pathways
13.26 TGFBR1 TGFB1 SMAD3 MAPK8 CDH1 CCN2
5
Show member pathways
12.99 TGFBR1 TGFB1 REN MAPK8 HIF1A CCN2
6
Show member pathways
12.85 TGFBR1 TGFB1 SMAD3 MAPK8 CDH1
7 12.82 TGFBR1 TGFB1 SMAD3 MAPK8 HIF1A CDH1
8
Show member pathways
12.6 TGFBR1 TGFB1 SMAD3 MAPK8 HIF1A
9
Show member pathways
12.47 TGFBR1 TGFB1 SPHK1 SMAD3 BMP7
10
Show member pathways
12.4 TGFB1 MAPK8 CDH1 CCN2 BMP7 BMP6
11
Show member pathways
12.39 SPHK1 MAPK8 HIF1A AGTR1
12 12.33 TGFBR1 TGFB1 SMAD3 MAPK8
13
Show member pathways
12.3 SERPINE1 MAPK8 HIF1A CCL2
14
Show member pathways
12.29 TGFBR1 TGFB1 SMAD3 SERPINE1
15
Show member pathways
12.27 TGFBR1 TGFB1 CCN2 BMP7 BMP6
16
Show member pathways
12.22 TGFBR1 TGFB1 SMAD3 MAPK8
17 12.19 TGFBR1 TGFB1 SMAD3 CDH1
18 12.16 TGFBR1 TGFB1 SMAD3 SERPINE1
19
Show member pathways
12.09 TGFBR1 TGFB1 SMAD3 MAPK8
20 12.07 TGFBR1 TGFB1 SMAD3 MAPK8
21 12.06 TGFB1 SMAD3 SERPINE1 HIF1A
22 12.02 TGFBR1 TGFB1 SMAD3 SERPINE1 ENG CCN2
23 12 TGFBR1 SPHK1 SMAD3 SERPINE1 CDH1 CCN2
24 11.9 TGFB1 ENG BMP7 BMP6
25 11.89 TGFBR1 TGFB1 SMAD3 MAPK8 ENG
26 11.87 TGFBR1 TGFB1 SMAD3 BMP7 BMP6
27
Show member pathways
11.85 TGFBR1 TGFB1 SMAD3
28
Show member pathways
11.84 TGFBR1 TGFB1 SMAD3
29
Show member pathways
11.82 TGFB1 REN NR3C2 AGTR1
30 11.8 TGFBR1 TGFB1 SMAD3 SERPINE1 MAPK8 CCL2
31
Show member pathways
11.79 TGFBR1 TGFB1 SMAD3 MAPK8
32 11.79 TGFBR1 TGFB1 REN HIF1A ENG CCL2
33 11.75 TGFBR1 TGFB1 SMAD3 SERPINE1
34 11.75 TGFBR1 TGFB1 SMAD3 SERPINE1 CDH1 CCN2
35 11.72 TGFBR1 SMAD3 CDH1
36
Show member pathways
11.71 TGFBR1 TGFB1 SMAD3
37 11.69 SMAD3 SERPINE1 HIF1A ENG
38 11.69 TGFBR1 TGFB1 SMAD3 MAPK8 BMP7 BMP6
39 11.68 SMAD3 MAPK8 HIF1A
40 11.67 TGFB1 BMP7 BMP6
41 11.67 TGFB1 CCN2 CCL2 BMP7
42
Show member pathways
11.63 TGFBR1 TGFB1 SMAD3 MAPK8
43 11.62 TGFBR1 TGFB1 SMAD3 SERPINE1 ENG
44 11.54 TGFBR1 TGFB1 SMAD3 MAPK8 HIF1A
45 11.53 TGFBR1 TGFB1 SMAD3 CCN2
46 11.45 TGFBR1 SMAD3 SERPINE1
47 11.28 TGFBR1 TGFB1 SMAD3
48 11.04 TGFB1 SMAD3 CDH1
49 11 TGFB1 MAPK8 CDH1 CCN2 CCL2 BMP7
50 10.57 TGFBR1 SMAD3 SERPINE1 MAPK8 ENG CCN2

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TGFB1 SERPINE1 REN MIR21 ENG CCN2
2 receptor complex GO:0043235 9.26 TGFBR1 SMAD3 NR3C2 ENG

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TGFB1 SMAD3 SERPINE1 RGCC HIF1A ENG
2 positive regulation of transcription, DNA-templated GO:0045893 10.19 TGFBR1 TGFB1 SMAD3 HIF1A CDH1 BMP7
3 negative regulation of cell proliferation GO:0008285 10.13 TGFB1 SMAD3 RGCC MIR21 BMP7
4 positive regulation of cell proliferation GO:0008284 10.11 TGFBR1 TGFB1 SPHK1 MIR21 MIR200B CCN2
5 inflammatory response GO:0006954 10.1 TGFB1 SPHK1 CCL2 BMP6 AGTR1
6 negative regulation of apoptotic process GO:0043066 10.09 TGFBR1 SPHK1 SMAD3 MIR21 MIR200B MAPK8
7 regulation of gene expression GO:0010468 10.08 TGFBR1 TGFB1 MAPK8 HIF1A CDH1
8 positive regulation of apoptotic process GO:0043065 10.07 TGFBR1 TGFB1 MIR21 MIR200B MAPK8 BMP7
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 TGFB1 MIR21 CCN2 CCL2
10 regulation of cell proliferation GO:0042127 10.03 TGFB1 HIF1A ENG AGTR1
11 positive regulation of cell migration GO:0030335 10.03 TGFBR1 TGFB1 SPHK1 SMAD3 MIR21
12 positive regulation of protein phosphorylation GO:0001934 10.02 TGFB1 MIR21 ENG CCN2
13 negative regulation of gene expression GO:0010629 10.01 TGFB1 MIR21 MIR200B HIF1A ENG CCN2
14 positive regulation of protein kinase B signaling GO:0051897 10 TGFBR1 TGFB1 MIR21 ENG
15 response to hypoxia GO:0001666 10 TGFB1 SMAD3 HIF1A ENG
16 cellular response to lipopolysaccharide GO:0071222 9.99 SERPINE1 MIR21 MAPK8 CCL2
17 negative regulation of cell migration GO:0030336 9.98 SERPINE1 MIR21 ENG CDH1
18 angiogenesis GO:0001525 9.97 TGFBR1 SERPINE1 HIF1A ENG CCN2 CCL2
19 skeletal system development GO:0001501 9.96 TGFBR1 SMAD3 BMP7 BMP6
20 positive regulation of angiogenesis GO:0045766 9.96 SPHK1 SERPINE1 MIR21 HIF1A ENG
21 positive regulation of inflammatory response GO:0050729 9.93 SERPINE1 MIR21 AGTR1
22 response to organic substance GO:0010033 9.92 TGFB1 REN CDH1
23 cell chemotaxis GO:0060326 9.92 ENG CCL2 AGTR1
24 wound healing GO:0042060 9.92 TGFBR1 TGFB1 SMAD3 ENG
25 cartilage development GO:0051216 9.91 HIF1A BMP7 BMP6
26 positive regulation of endothelial cell proliferation GO:0001938 9.91 TGFBR1 HIF1A BMP6
27 positive regulation of osteoblast differentiation GO:0045669 9.91 MIR21 BMP7 BMP6
28 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.91 TGFBR1 TGFB1 SMAD3 ENG
29 kidney development GO:0001822 9.91 TGFBR1 REN BMP7 BMP6 AGTR1
30 cellular response to growth factor stimulus GO:0071363 9.9 TGFBR1 TGFB1 SPHK1
31 cellular response to mechanical stimulus GO:0071260 9.9 TGFB1 MAPK8 ENG BMP6
32 heart looping GO:0001947 9.89 SMAD3 HIF1A ENG
33 cellular response to transforming growth factor beta stimulus GO:0071560 9.89 TGFBR1 TGFB1 SMAD3
34 blood vessel development GO:0001568 9.88 SPHK1 MIR21 HIF1A
35 SMAD protein signal transduction GO:0060395 9.88 TGFB1 SMAD3 BMP7 BMP6
36 negative regulation of blood vessel endothelial cell migration GO:0043537 9.86 TGFB1 RGCC MIR200B
37 positive regulation of protein import into nucleus GO:0042307 9.85 TGFB1 SMAD3 CDH1
38 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.83 TGFB1 SMAD3 HIF1A
39 positive regulation of stress fiber assembly GO:0051496 9.83 TGFBR1 SMAD3 RGCC CCN2
40 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 TGFBR1 TGFB1 SMAD3 MIR21 ENG
41 ureteric bud development GO:0001657 9.82 TGFB1 SMAD3 BMP7
42 positive regulation of cell cycle arrest GO:0071158 9.81 TGFB1 RGCC MIR200B
43 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.81 TGFB1 SPHK1 BMP7
44 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.79 TGFB1 SMAD3 ENG
45 negative regulation of endothelial cell proliferation GO:0001937 9.78 TGFBR1 RGCC MIR21 ENG
46 positive regulation of SMAD protein signal transduction GO:0060391 9.76 TGFBR1 TGFB1 BMP6
47 positive regulation of bone mineralization GO:0030501 9.76 TGFB1 SMAD3 BMP7 BMP6
48 pathway-restricted SMAD protein phosphorylation GO:0060389 9.75 TGFBR1 TGFB1
49 ventricular trabecula myocardium morphogenesis GO:0003222 9.75 TGFBR1 ENG
50 mesonephros development GO:0001823 9.75 REN BMP7

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 TGFB1 CCL2 BMP7 BMP6
2 I-SMAD binding GO:0070411 9.4 TGFBR1 SMAD3
3 BMP receptor binding GO:0070700 9.37 BMP7 BMP6
4 type I transforming growth factor beta receptor binding GO:0034713 9.26 TGFB1 ENG
5 growth factor activity GO:0008083 9.26 TGFB1 CCN2 BMP7 BMP6
6 transforming growth factor beta-activated receptor activity GO:0005024 9.16 TGFBR1 ENG
7 type II transforming growth factor beta receptor binding GO:0005114 8.8 TGFBR1 TGFB1 ENG

Sources for Renal Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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