Renal Hypertension disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RNL015 MIFTS: 45	Renal Hypertension Categories: Cardiovascular diseases, Ear diseases, Genetic diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Renal Hypertension

MalaCards integrated aliases for Renal Hypertension:

Name: Renal Hypertension ¹² ⁷³ ¹⁵ ¹⁷ ⁷⁰

Hypertension, Renal ⁴⁴

Hypertension Renal ⁵⁴

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases Nephrological diseases Ear diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1073

MeSH ⁴⁴ D006977

NCIt ⁵⁰ C3121

SNOMED-CT ⁶⁷ 194775007

EFO ¹⁷ EFO_1002039

UMLS ⁷⁰ C0020544

Sources

Summaries for Renal Hypertension

MalaCards based summary : Renal Hypertension, also known as hypertension, renal, is related to chronic pyelonephritis and perinephritis. An important gene associated with Renal Hypertension is EDN1 (Endothelin 1), and among its related pathways/superpathways are Pathways in cancer and Development Angiotensin activation of ERK. The drugs Bisoprolol and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : ⁷³ Renovascular hypertension is a condition in which high blood pressure is caused by the kidneys' hormonal... more...

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Related Diseases for Renal Hypertension

Diseases in the Renal Hypertension family:

Renal Failure, Progressive, with Hypertension

Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)

#	Related Disease	Score	Top Affiliating Genes
1	chronic pyelonephritis	30.8	REN ALB ACE
2	perinephritis	30.6	REN EDN1 ACE
3	renovascular hypertension	30.5	REN NPPB NOS3 EDN1 AGTR1 ADM
4	uremia	30.5	REN EPO ALB ACE
5	proteinuria, chronic benign	30.5	REN APOL1 ALB AGTR1 ACE
6	fibromuscular dysplasia	30.4	REN AGTR1 AGT ACE
7	acute kidney failure	30.4	REN KNG1 ALB
8	pure autonomic failure	30.4	REN EPO DBH ACE
9	glomerulonephritis	30.4	MYH9 APOL1 ALB AGTR1 ACE
10	malignant hypertension	30.3	REN NPPB EDN1 AGTR1 AGT ADM
11	atherosclerosis susceptibility	30.2	NOS3 EDN1 ALB AGTR1 ACE
12	microvascular complications of diabetes 3	30.2	REN ALB AGTR1 ACE
13	hypertensive encephalopathy	30.1	REN EPO EDN1 ALB AGTR1 ACE
14	malignant renovascular hypertension	30.1	REN EDN1 AGTR1
15	coronary stenosis	30.1	NPPB ALB ACE
16	pheochromocytoma	30.1	REN KNG1 EPO EDN1 DBH ADM
17	urinary tract obstruction	30.0	REN ALB ACE
18	benign essential hypertension	30.0	REN ALB
19	hypokalemia	30.0	SLC12A3 REN ALB ACE
20	gitelman syndrome	30.0	SLC12A3 REN AGT
21	peripheral vascular disease	29.9	KNG1 EPO ALB ACE
22	renal dysplasia	29.8	REN AGTR1 AGT ACE
23	vascular disease	29.7	REN NPPB NOS3 KNG1 EPO EDN1
24	renal fibrosis	29.7	REN MIR200B ALB AGTR1 AGT
25	polycystic kidney disease	29.5	REN NOS3 EPO EDN1 ALB AGTR1
26	eclampsia	29.5	REN NOS3 EDN1 ALB AGT ACE
27	diastolic heart failure	29.4	REN NPPB NOS3 AGTR1 AGT ACE
28	autosomal dominant polycystic kidney disease	29.3	REN NOS3 EDN1 ALB AGTR1 AGT
29	pulmonary hypertension	29.3	REN NPPB NOS3 EDN1 ALB AGTR1
30	sleep apnea	29.3	REN NPPB NOS3 EPO EDN1 ALB
31	pre-eclampsia	29.2	REN NOS3 KNG1 EDN1 ALB AGTR1
32	congestive heart failure	29.0	REN NPPB NOS3 KNG1 EPO EDN1
33	end stage renal disease	28.9	REN NPPB NOS3 MYH9 EPO APOL1
34	hypertension, essential	28.9	SLC12A3 REN NPPB NOS3 MYH9 KNG1
35	kidney disease	28.8	SLC12A3 REN NPPB NOS3 MYH9 MIR200A
36	chronic kidney disease	28.8	REN NPPB NOS3 MYH9 EPO EDN1
37	hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome	11.7
38	polycystic kidney disease 4 with or without polycystic liver disease	10.9
39	polycystic kidney disease 3 with or without polycystic liver disease	10.9
40	c3 glomerulopathy 3	10.9
41	stress polycythemia	10.5	EPO ALB
42	cardiac tuberculosis	10.4	NPPB ACE
43	microvascular complications of diabetes 2	10.4	EPO ACE
44	chronic thromboembolic pulmonary hypertension	10.4	NPPB EDN1
45	polycystic kidney disease 4	10.4	NPPB ALB
46	renal artery obstruction	10.4	REN ACE
47	hypoaldosteronism	10.4	REN ACE
48	toxic myocarditis	10.4	NPPB ACE
49	pericarditis	10.4	NPPB ALB ACE
50	acute pulmonary heart disease	10.4	REN NPPB

Graphical network of the top 20 diseases related to Renal Hypertension:

Sources

Symptoms & Phenotypes for Renal Hypertension

MGI Mouse Phenotypes related to Renal Hypertension:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.97	ACE ADM AGT AGTR1 ALB DBH
2	homeostasis/metabolism	MP:0005376	9.83	ACE ADM AGT AGTR1 ALB DBH
3	renal/urinary system	MP:0005367	9.32	ACE ADM AGT AGTR1 ALB EDN1

Sources

Drugs & Therapeutics for Renal Hypertension

Drugs for Renal Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bisoprolol

Approved

Phase 4

66722-44-9

2405

Synonyms:

(+-)-1-((a-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol

(+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol

(+-)-1-((Α-(2-isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol

(RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol

1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol

1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol

1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol

66722-44-9

AB00514681

AC-18540

AC1L1DLQ

AKOS005110983

ARONIS24082

Bisocor

Bisoprolol

BISOPROLOL

Bisoprolol (USAN/INN)

Bisoprolol [USAN:BAN:INN]

Bisoprolol fumarate

Bisoprolol Fumarate

Bisoprolol fumarate (1:1) salt, (+-)-isomer

Bisoprolol fumarate (2:1) salt, (+-)-isomer

Bisoprolol fumerate

Bisoprolol hemifumarate

Bisoprolol Hemifumarate

Bisoprolol hydrochloride

Bisoprolol methanesulfonate salt

Bisoprolol, (-)-isomer

Bisoprolol, (+-)-isomer

Bisoprolol, fumarate (1:1) salt

Bisoprolol, fumarate (2:1) salt

Bisoprololum

Bisoprololum [Latin]

BPBio1_000373

BSPBio_000339

C06852

C18H31NO4

Cardicor

CHEBI:3127

CHEMBL645

CID2405

CL-297939

Concor

Condyline

Condylox

D02342

DB00612

Detensiel

Emconcor

Emcor

EMD-33512

EMD-33-512

Euradal

Fumarate, bisoprolol

Hydrochloride, bisoprolol

I01-7040

Isoten

L000133

LS-122509

Merck brand OF bisoprolol fumarate

MolPort-005-937-320

Monocor

NCGC00024868-02

NCGC00024868-03

NCGC00024868-04

NCGC00024868-05

Prestwick0_000330

Prestwick1_000330

Prestwick2_000330

Prestwick3_000330

SBB065120

Soloc

Soprol

SPBio_002260

UNII-Y41JS2NL6U

Zebeta

Amlodipine

Approved

Phase 4

88150-42-9

2162

Synonyms:

()-Amlodipine

(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)

-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat

3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid

3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

88150-42-9

88150-47-4 (maleate (1:1))

AC1L1D26

AC1Q32ZS

AC-4535

Almirall brand OF amlodipine besilate

Ambap88150-42-9

Amlocard

amlodipine

Amlodipine

Amlodipine (INN)

Amlodipine [INN:BAN]

AMLODIPINE BASE

Amlodipine Benzenesulfonate

Amlodipine besilate

Amlodipine Besilate

Amlodipine besylate

Amlodipine Besylate

Amlodipine free base

Amlodipine Free Base

Amlodipine maleate

Amlodipine maleate (1:1)

Amlodipine, (+-)-isomer

Amlodipine, (+-)-isomer, maleate (1:1)

Amlodipine, (R)-isomer

Amlodipine, (S)-isomer, maleate (1:1)

Amlodipino

Amlodipino [Spanish]

Amlodipinum

Amlodipinum [Latin]

Amlodis

Amlopres

Amlor

Amvaz

AMVAZ

Astudal

BIDD:GT0810

BRD-A22032524-074-02-4

BRD-A22032524-074-03-2

BSPBio_002727

C06825

CHEBI:2668

CHEMBL1491

CID2162

Coroval

CPD000469198

D07450

DB00381

Eczacibasi brand OF amlodipine besilate

HMS2052N03

HMS2089H07

I14-0798

Intervask

Istin

KBio3_001947

KBioGR_001643

Lipinox

Lotrel

LS-131183

Mack brand OF amlodipine besilate

MLS001401409

MolPort-001-792-963

NCGC00165957-01

NCGC00165957-02

NCGC00165957-03

Norvasc

Norvasc (TN)

Pelmec

Pfizer brand OF amlodipine besilate

R,S)-Amlodipine

Racemic amlodipine

Racemic Amlodipine

SAM001246705

SMR000469198

SPBio_000351

Spectrum2_000486

Spectrum3_001004

Spectrum4_001132

Spectrum5_001550

UK-4834011

UNII-1J444QC288

Antihypertensive Agents

Phase 4

Vasodilator Agents

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic beta-1 Receptor Antagonists

Phase 4

Hormones

Phase 4

Adrenergic Agents

Phase 4

Neurotransmitter Agents

Phase 4

calcium channel blockers

Phase 4

Calcium, Dietary

Phase 4

Sympatholytics

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Synonyms:

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium(2+)

Calcium, doubly charged positive ion

Calcium, elemental

Elemental calcium

Kalzium

Ramipril

Approved

Phase 2, Phase 3

87333-19-5

5362129

Synonyms:

(2 S ,3 aS ,6 aS )-1[( S )-N-[( S )-1-Carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta [ b ]pyrrole-2-carboxylic acid, 1-ethyl ester

(2S-(1(R*(r*)),2a,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylate

(2S-(1(R*(r*)),2a,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid

(2S-(1(R*(r*)),2alpha,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylate

(2S-(1(R*(r*)),2alpha,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid

(2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid

(2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid.

(2S-(1(R*(r*)),2α,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylate

(2S-(1(R*(r*)),2α,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid

(2S,3aS,6aS)-1-((S)-2-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl) octahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2s,3as,6as)-1-((s)-2-((s)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)-octahydrocyclopenta[b]p

(2s,3as,6as)-1((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic

(2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, 1-ethyl ester

(2S,3aS,6aS)-1-((S)-N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrol-2-carbonsaeure

(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid

(2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (non-preferred name)

(2s,3as,6as)-1-[(s)-2-((s)-1-ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-cyclopenta[b]

[2s,3as,6as]-1-[(2s)-2-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopen

[2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

126613-39-6

87333-19-5

AC-1347

AC1NSFPR

Acovil

Almirall brand OF ramipril

Almirall Brand of Ramipril

Altace

Altace (TN)

Astra brand OF ramipril

Astra Brand of Ramipril

AstraZeneca brand OF ramipril

AstraZeneca Brand of Ramipril

Aventis brand OF ramipril

Aventis Brand of Ramipril

Aventis pharma brand OF ramipril

Aventis Pharma Brand of Ramipril

BIDD:GT0803

Bio-0651

BSPBio_003347

C23H32N2O5

Carasel

Cardace

CHEBI:289203

CHEBI:8774

CHEMBL1168

CID5362129

CPD000466386

D00421

D017257

DB00178

Delix

HMS2051E04

HMS2090L11

HMS2093M10

HOE 498

Hoe-498

HOE498

HOE-498

Hoechst brand OF ramipril

Hoechst Brand of Ramipril

Hypren

Hytren

KBio2_002504

KBio2_005072

KBio2_007640

KBio3_002849

KBioGR_001858

KBioSS_002512

Lostapres

LS-58199

MLS000759523

MLS001216547

MLS001423965

MolPort-001-736-571

Monarch brand OF ramipril

Monarch Brand of Ramipril

N-(1S-carboethoxy-3-phenylpropyl)-S-alanyl-cis,endo-2-azabicyclo[3.3.0]octane-3S-carboxylic Acid

Naprix

NCGC00178127-01

Pramace

Pramace (discontinued)

Promed brand OF ramipril

Promed Brand of Ramipril

Quark

R0404_SIGMA

Ramace

ramipril

Ramipril

Ramipril (USP/INN)

Ramipril [USAN:INN:BAN]

Ramiprilum

Ramiprilum [Latin]

Ramipro, Tritace, Altace, Prilace, Ramipril

S1793_Selleck

SAM001246757

SAM002699899

SMR000466386

Spectrum_001958

SPECTRUM1505214

Spectrum3_001794

Spectrum4_001269

Spectrum5_001721

STK801937

Triatec

Tritace

UNII-L35JN3I7SJ

Unipril

Vesdil

Zabien

Diltiazem

Approved, Investigational

Phase 2, Phase 3

42399-41-7

39186

Synonyms:

(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester

(+)-cis-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester

(+)-cis-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetic acid ester

(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate

(2S,3S)-5-(2-(Dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate

(2S,3S)-5-(2-(Dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetic acid

(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate

(2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate

(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate

144604-00-2

33286-22-5

42399-41-7

AC1L2181

AC1Q6LHX

AC-936

Acalix

Acetate (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Adizem

Aldizem

Altiazem

Anginyl

Angizem

Anoheal

Apo-Diltiaz

BIDD:GT0548

Bio1_000371

Bio1_000860

Bio1_001349

Biovail brand OF diltiazem hydrochloride

BPBio1_000230

BRD-K24023109-001-02-5

BRD-K24023109-003-03-9

Britiazim

BRN 3573079

Bruzem

BSPBio_000208

BSPBio_001311

C06958

C22H26N2O4S

Calcicard

Cardil

Cardizem

Cardizem (Hydrochloride)

Cardizem CD

Cardizem SR

Cardizen LA

Cartia XT

CHEBI:101278

CHEMBL23

CID39186

Citizem

Cormax

CRD 401

CRD-401

D07845

DB00343

d-cis-diltiazem

d-cis-Diltiazem

D-cis-Diltiazem

Deltazen

Dilacor

Dilacor XR

Dilacor-XR

Diladel

Dilcontin

Dilpral

Dilren

Dilrene

Dilta-Hexal

Dilt-cd

Diltia

diltiazem

Diltiazem

Diltiazem (INN)

Diltiazem [INN:BAN]

Diltiazem hydrochloride

Diltiazem malate

Diltiazemum

Diltiazemum [INN-Latin]

Dilticard

Diltzac

Dilzem

Dilzen

EINECS 255-796-4

Endrydil

FT-0081415

Herbesser

HMS1791B13

HMS1989B13

HMS2089H09

HSDB 6528

Incoril AP

Lopac0_000327

LS-40510

Masdil

MK-793 (Malate)

MolPort-002-509-369

NCGC00024309-02

NCGC00024309-04

NCGC00024309-05

NCGC00024309-06

NCGC00024309-07

NCGC00024309-08

NCGC00024309-09

NCGC00024309-10

nchembio.368-comp1

Novo-Diltazem

Nu-Diltiaz

Prestwick0_000134

Prestwick1_000134

Prestwick2_000134

Prestwick3_000134

RG 83606 (Hydrochloride)

SPBio_002147

STOCK1N-03672

Surazem

Surazem (TN)

Syn-Diltiazem

Tiamate

Tiazac

Tiazac Tildiem

Tiazac XC

Tocris-0685

UNII-EE92BBP03H

Viazem

Watson pharmaceuticals brand OF diltazem

Hydralazine

Approved

Phase 2, Phase 3

86-54-4

3637

Synonyms:

(1Z)-1(2H)-Phthalazinone hydrazone

(2H)-Phthalazinone hydrazone

[2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride

1(2H)-Phthalazinone hydrazone

1(2H)-Phthalazinone, hydrazone

1-Hydrazinophthalazine

1-Phthalazinylhydrazine

304-20-1 (mono-hydrochloride)

5-25-17-00412 (Beilstein Handbook Reference)

6-Hydralazine

86-54-4

AC1L1GDN

AC1Q4UY1

AKOS000122609

Apresolin

Apresoline

Apressin

Apressin (pharmaceutical)

Apressoline

Aprezolin

BA 5968

BRD-K82103381-003-03-7

BRN 0132615

BSPBio_002130

C 5968

C07040

C-5068

C-5968

C8H8N4

CAS-304-20-1

CCRIS 5385

CHEBI:5775

CHEMBL276832

Ciba 5968

CID3637

D08044

DB01275

DivK1c_000117

EC-000.1838

EINECS 201-680-3

Hidral

Hidral (TN)

Hidralazin

Hidralazina

Hidralazina [INN-Spanish]

Hidralazina [Spanish]

Hipoftalin

HLZ

Hydralazin

hydralazine

Hydralazine

Hydralazine (INN)

Hydralazine [INN:BAN]

Hydralazine hydrochloride

Hydralazine mono hydrochloride

Hydralazine mono-hydrochloride

Hydralazinum

Hydralazinum [INN-Latin]

Hydrallazin

Hydrallazine

Hydrazinophthalazine

Hydrazone 1(2H)-phthalazinone

Hydrochloride, hydralazine

Hypophthalin

IDI1_000117

Idralazina

Idralazina [DCIT]

Idralazina [Italian]

InChI=1/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)

KBio1_000117

KBio2_001355

KBio2_003923

KBio2_006491

KBio3_001350

KBioGR_000349

KBioSS_001355

Lopac0_000593

Lopac-H-1753

LS-109171

MolPort-000-876-738

MolPort-001-794-088

mono-Hydrochloride, hydralazine

NCGC00015501-01

NCGC00015501-02

NCGC00015501-05

NCGC00162199-01

NCIOpen2_001484

Nepresol

NINDS_000117

NSC 126699

NSC126699

Oprea1_207681

Oprea1_416878

phthalazin-1-ylhydrazine

Phthalazin-1-ylhydrazine

Praparat 5968

Prestwick0_000169

Prestwick1_000169

Prestwick2_000169

SPBio_000977

SPBio_001958

Spectrum_000875

Spectrum2_000969

Spectrum3_000455

Spectrum4_000005

Spectrum5_000822

ST50512087

UNII-26NAK24LS8

WLN: T66 CNNJ BMZ

ZINC12360535

rituximab

Approved

Phase 2

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

Mabthera

MabThera

Rituxan

rituximab

Rituximab

rituximab-abbs

rituximab-arrx

rituximab-pvvr

Mycophenolic acid

Approved

Phase 1, Phase 2

24280-93-1

446541

Synonyms:

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid

Acid, mycophenolic

Acide mycophenolique

Acido micofenolico

Acidum mycophenolicum

Cellcept

Melbex

Micofenolico acido

Mofetil hydrochloride, mycophenolate

Mofetil, mycophenolate

Mycophenoic acid

Mycophenolate

Mycophenolate mofetil

Mycophenolate mofetil hydrochloride

Mycophenolate sodium

Mycophenolate, sodium

Mycophenolic acid

Mycophenolic acid morpholinoethyl ester

Mycophenolsaeure

Mycophenolsäure

Myfortic

Sodium mycophenolate

Immunoglobulins

Phase 2

Antibodies

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Antirheumatic Agents

Phase 2

Immunologic Factors

Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Antibiotics, Antitubercular

Phase 1, Phase 2

Antitubercular Agents

Phase 1, Phase 2

Anti-Infective Agents

Phase 1, Phase 2

Anticoagulants

Liver Extracts

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.	Completed	NCT04085562	Phase 4	Bisoprolol Fumarate 5-10 mg;Amlodipine 5-10 mg
2	African American Study of Kidney Disease and Hypertension ABPM Pilot Study	Completed	NCT00582777	Phase 2, Phase 3	ADD On Dosing
3	The Highly Sensitized Patients: Effects of Mycophenolate Mofetil (MMF) On Anti-Human Leukocyte Antigen (HLA) Antibody Levels In Patients Awaiting Cadaveric Renal Transplant	Completed	NCT00446459	Phase 2	mycophenolate mofetil (CellCept)
4	The Highly Sensitized Patients: Effects of Rituximab and Mycophenolate Mofetil (MMF) On Anti-Human Leukocyte Antigen (HLA) Antibody Levels In Patients Awaiting Cadaveric Renal Transplant.	Completed	NCT00446251	Phase 2	Rituximab;Mycophenolate mofetil (MMF)
5	Comparing the Effects of an Immunosuppressant (Mycophenolate Mofetil or MMF) on the Urinary Sodium Excretion Response to Mental Stress in a Crossover Design (MMF)	Recruiting	NCT02432339	Phase 1, Phase 2	mycophenolate mofetil (MMF);Placebo
6	A Prospective, Multi-Center, Non-Randomized Feasibility Study of Catheter-Based Renal Denervation to Treat Resistant Hypertension (RENABLATE- EC12-02)	Completed	NCT01756300	Phase 1
7	A Prospective, Multi-center, Non-Randomized, Feasibility Study of Catheter Based Renal Denervation to Treat Resistant Hypertension (RENABLATE-II - 157)	Completed	NCT02095691	Phase 1
8	Risk of Bleeding and Anticoagulation in Atrial Fibrillation: What Predictive Criterion Used?	Completed	NCT02858518
9	Electroacupuncture for Hypertension Patients With Chronic Kidney Disease	Completed	NCT01766427
10	Renin and Aldosterone Levels in the Preterm Neonate At Risk for Hypertension (RENAL HIT Study)	Completed	NCT01549444
11	A Clinical Trial to Assess the Safety and Efficacy of the RX Herculink(R) Elite(TM) Renal Stent System for the Treatment of Suboptimal Post-procedural Percutaneous Transluminal Angioplasty (PTA) in de Novo or Restenotic Renal Artery Stenoses in Patients With Uncontrolled Hypertension.	Completed	NCT00490841
12	Clinical Outcome of Patients With Resistant Hypertension Undergoing Renal Denervation: A Report From the Swedish Registry for Renal Denervation	Recruiting	NCT04722159
13	Effectiveness of Implementation of a Patient-centered Self-management Program in Patients With Hypertensive Nephropathy	Recruiting	NCT04633993

Search NIH Clinical Center for Renal Hypertension

Cochrane evidence based reviews: hypertension, renal

Sources

Genetic Tests for Renal Hypertension

Sources

Anatomical Context for Renal Hypertension

MalaCards organs/tissues related to Renal Hypertension:

⁴⁰

Kidney, Heart, Liver, Endothelial, Brain, Cortex, Smooth Muscle

Sources

Publications for Renal Hypertension

Articles related to Renal Hypertension:

(show top 50) (show all 3254)

#	Title	Authors	PMID	Year
1	[Management of renal atrophy in hypertensive patients: experience in Lille]. ⁶¹ ⁵⁴	Marboeuf P...Mounier-Vehier C	19854024	2010
2	Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. ⁵⁴ ⁶¹	Modesti PA...Parati G	16982943	2006
3	Aspirin use in older patients with heart failure and coronary artery disease: national prescription patterns and relationship with outcomes. ⁶¹ ⁵⁴	Masoudi FA...Krumholz HM	16168275	2005
4	Association study of calcitonin-receptor-like receptor gene in essential hypertension. ⁵⁴ ⁶¹	Sano M...Kokubun S	15797661	2005
5	The clinical use of angiotensin-converting enzyme inhibitors. ⁶¹ ⁵⁴	Wong J...Kowey PR	15586352	2004
6	Angiotensin AT-1 receptor antagonism: complementary or alternative to ACE inhibition in cardiovascular and renal disease? ⁵⁴ ⁶¹	Doggrell SA	12437489	2002
7	Methods for assessing endothelin ETA-receptor antagonists in preclinical studies. ⁶¹ ⁵⁴	Okada M...Nishikibe M	12224443	2002
8	Endothelin and heart failure. ⁶¹ ⁵⁴	Nambi P...Feuerstein G	11447308	2001
9	Blacks with hypertension, renal insufficiency, and baseline proteinuria benefit more from ACE inhibition than from calcium channel blockade. ⁶¹ ⁵⁴	Basile JN	11675775	2001
10	Development of ideas on renovascular hypertension. ⁵⁴ ⁶¹	Peart S	11022890	2000
11	[The protection of renal function in the ACEI treatment of renal hypertension]. ⁵⁴ ⁶¹	Zhou QL...Chen LP	12206011	2000
12	Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor. ⁵⁴ ⁶¹	Abe F...Takanashi N	10604545	1999
13	[Adrenomedullin]. ⁵⁴ ⁶¹	Beltowski J	10352550	1999
14	[Study on the relationship between plasma endothelin nitric oxide concentration and renal hypertension and renal function]. ⁶¹ ⁵⁴	Zhou Q...Zhou H	12080656	1999
15	Anti-ischaemic effects of ACE inhibitors: review of current clinical evidence and ongoing clinical trials. ⁵⁴ ⁶¹	Yusuf S...Lonn E	9796839	1998
16	Endothelin as a regulator of cardiovascular function in health and disease. ⁵⁴ ⁶¹	Haynes WG...Webb DJ	9794709	1998
17	Adrenomedullin: a new hypotensive peptide. ⁶¹ ⁵⁴	Kangawa K...Matsuo H	9120666	1996
18	Adrenomedullin: a new modulator of vascular tone. ⁵⁴ ⁶¹	Kangawa K...Matsuo H	8951571	1996
19	[Arterial hypertension in patients on chronic hemodialysis]. ⁵⁴ ⁶¹	Zogovic J...Mladenovic Lj	9102857	1996
20	Therapeutic advantages of angiotensin converting enzyme inhibitors in chronic renal disease. ⁵⁴ ⁶¹	Omata K...Abe K	8743512	1996
21	[A protein-restricted diet combined with ACE inhibitors does not improve insulin sensitivity in renal hypertension]. ⁶¹ ⁵⁴	Spustova V...Dzurik R	8686202	1996
22	Role of bradykinin in the antihypertensive and cardioprotective actions of converting enzyme inhibitors. ⁶¹ ⁵⁴	Zhu YC...Unger T	8846416	1995
23	Relation between renin and prorenin in plasma from hypertensive patients and normal people: evidence for different renin:prorenin ratios. ⁵⁴ ⁶¹	Leckie BJ...Morton JJ	7473533	1995
24	[The use of angiotensin-converting enzyme inhibitors in chronic diffuse kidney diseases]. ⁵⁴ ⁶¹	Kutyrina IM...Miroshnichenko NG	7638769	1995
25	Dopamine beta-hydroxylase immunoreactivity in human cerebrospinal fluid: properties, relationship to central noradrenergic neuronal activity and variation in Parkinson's disease and congenital dopamine beta-hydroxylase deficiency. ⁶¹ ⁵⁴	O'Connor DT...Biaggioni I	8143425	1994
26	Renal vein renin analysis: limitations of its use in predicting benefit from percutaneous angioplasty. ⁵⁴ ⁶¹	Martin LG...Wells JO	8485747	1993
27	Urinary kallikrein excretion is low in malignant essential hypertension. ⁵⁴ ⁶¹	Hilme E...Hansson L	1325521	1992
28	Angiotensin converting enzyme inhibitors in cardiovascular and renal disease in Africans: a review. ⁵⁴ ⁶¹	Ajayi AA	1908620	1991
29	COVID-19 in Adults With Congenital Heart Disease. ⁶¹	Broberg CS...Aboulhosn JA	33795039	2021
30	Novel SARS2 variants identified in a Chinese girl with HUPRA syndrome. ⁶¹	Zhou Y...Wang M	33751860	2021
31	Autosomal Recessive Polycystic Kidney Disease-The Clinical Aspects and Diagnostic Challenges. ⁶¹	Wicher D...Jankowska I	33552631	2021
32	COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry. ⁶¹	Porta-Etessam J...Estrada V	33646505	2021
33	Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression. ⁶¹	Chia TY...Akhtar S	33728924	2021
34	Perceptions among Muslims regarding fasting, medication use and provider engagement during Ramadan in the United States. ⁶¹	Alshehri AM...Qureshi S	33711183	2021
35	Native nephrectomy in the management of hypertension in children with kidney disease: a tool to improve blood pressure control. ⁶¹	Varik RS...Mishra P	33683431	2021
36	Resumé of the challenges and burden of living with transplanted hearts for >31 years. ⁶¹	Javier Delmo EM...Hetzer R	33708489	2021
37	Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension. ⁶¹	Bergo KK...Fadl Elmula FEM	32633141	2021
38	A Positive Cocaine Urine Toxicology Test and the Effect on Intraoperative Hemodynamics Under General Anesthesia. ⁶¹	Moon TS...Ogunnaike B	32304462	2021
39	Renal metabolism and hypertension. ⁶¹	Tian Z...Liang M	33574248	2021
40	Risk factors for readmission with dehydration after ileostomy formation: A systematic review and meta-analysis. ⁶¹	Liu C...Bissett I	33539646	2021
41	Changes in sympathetic nervous system activity after renal denervation: results from the randomised Oslo RDN study. ⁶¹	Undrum Bergland O...Fadl Elmula FEM	33399016	2021
42	A review of indications and comorbidities in which warfarin may be the preferred oral anticoagulant. ⁶¹	Wadsworth D...Kim J	33393699	2021
43	Medical history of nocturnal enuresis during school age is an independent risk factor for nocturia in adults: The Nagahama study. ⁶¹	Negoro H...Nagahama Study Group	33118643	2021
44	Effects of catheter-based renal denervation on glycemic control and lipid levels: a systematic review and meta-analysis. ⁶¹	Zhang Z...Chen X	33459896	2021
45	Spontaneous Neuronal Plasticity in the Contralateral Motor Cortex and Corticospinal Tract after Focal Cortical Infarction in Hypertensive Rats. ⁶¹	Huang X...Chen L	32992200	2020
46	Predictors of renal damage in systemic lupus erythematous patients: data from a multiethnic, multinational Latin American lupus cohort (GLADEL). ⁶¹	Reategui-Sokolova C...GLADEL	33310863	2020
47	Correlations between indices of dynamic components of ambulatory blood pressure and renal damage in elderly Chinese male with essential hypertension. ⁶¹	Leng WX...Hu YX	32769403	2020
48	Biclonal gammopathay in a case of severe COVID-19. ⁶¹	Vashistha P...Chandra Koner B	33159954	2020
49	Pregnancy outcomes amongst adolescents/young adults at tertiary-care hospital in a low-middle-income country: Ten-year retrospective record review. ⁶¹	Amerjee A...Hashmi R	33475588	2020
50	Development and Internal Validation of A Prediction Tool To Assist Clinicians Selecting Second-Line Therapy Following Metformin Monotherapy For Type 2 Diabetes. ⁶¹	El Sanadi CE...Kattan MW	33685669	2020

Sources

Genes for Renal Hypertension

Genes related to Renal Hypertension (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	EDN1	Endothelin 1	Protein Coding	18.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12080656 16982943 11447308 (more) 9794709 12206011 12224443
2	REN	Renin	Protein Coding	17.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11022890 9102857 19854024 (more) 8485747 7473533
3	ACE	Angiotensin I Converting Enzyme	Protein Coding	15.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15586352 8743512 16168275 (more) 7638769 11675775 12437489 1908620 9796839 10604545 8686202
4	ALB	Albumin	Protein Coding	13.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	EPO	Erythropoietin	Protein Coding	12.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	KLKB1	Kallikrein B1	Protein Coding	10.86	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1325521
7	ADM	Adrenomedullin	Protein Coding	10.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9120666 10352550 8951571 (more) 15797661
8	SLC12A3	Solute Carrier Family 12 Member 3	Protein Coding	10.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	NPPB	Natriuretic Peptide B	Protein Coding	10.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	KNG1	Kininogen 1	Protein Coding	10.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8846416
11	MIR200B	MicroRNA 200b	RNA Gene	8.69	DISEASES inferred ¹⁵ ¹⁵
12	MIR141	MicroRNA 141	RNA Gene	8.67	DISEASES inferred ¹⁵ ¹⁵
13	MIR200A	MicroRNA 200a	RNA Gene	8.62	DISEASES inferred ¹⁵ ¹⁵
14	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	7.44	DISEASES inferred ¹⁵
15	DBH	Dopamine Beta-Hydroxylase	Protein Coding	7.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8143425
16	GPR182	G Protein-Coupled Receptor 182	Protein Coding	6.78	Novoseek inferred ⁵⁴	9120666 8951571
17	APOL1	Apolipoprotein L1	Protein Coding	6.67	DISEASES inferred ¹⁵
18	AGT	Angiotensinogen	Protein Coding	6.62	DISEASES inferred ¹⁵
19	MYH9	Myosin Heavy Chain 9	Protein Coding	6.5	DISEASES inferred ¹⁵
20	NOS3	Nitric Oxide Synthase 3	Protein Coding	6.3	DISEASES inferred ¹⁵
21	FN1	Fibronectin 1	Protein Coding	6.26	DISEASES inferred ¹⁵
22	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	6.26	DISEASES inferred ¹⁵
23	KLK4	Kallikrein Related Peptidase 4	Protein Coding	6.24	DISEASES inferred ¹⁵
24	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.2	DISEASES inferred ¹⁵
25	NPHS1	NPHS1 Adhesion Molecule, Nephrin	Protein Coding	6.1	DISEASES inferred ¹⁵
26	NOX4	NADPH Oxidase 4	Protein Coding	6.09	DISEASES inferred ¹⁵
27	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	6.02	DISEASES inferred ¹⁵

Sources

Variations for Renal Hypertension

Sources

Expression for Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Sources

Pathways for Renal Hypertension

Pathways related to Renal Hypertension according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.62	KNG1 EPO EDN1 AGTR1 AGT
2	Development Angiotensin activation of ERK ²³ Show member pathways Cell adhesion Integrin inside-out signaling ²³ Development ACM2 and ACM4 activation of ERK ²³ Development Angiotensin signaling via PYK2 ²³ Development EDNRB signaling ²³ Development EPO-induced MAPK pathway ²³ Development G-Proteins mediated regulation MARK-ERK signaling ²³ Signal transduction IP3 signaling ²³	12.59	NOS3 EPO EDN1 AGTR1 AGT
3	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.27	NPPB NOS3 KNG1 AGTR1 AGT
4	Oxytocin signaling pathway ³⁶ Show member pathways Vascular smooth muscle contraction ³⁶	11.96	NPPB NOS3 MYH9 EDN1 AGTR1 AGT
5	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.62	NOS3 EDN1 AGTR1 AGT
6	HIF-1-alpha transcription factor network ¹	11.47	EPO EDN1 ADM
7	Renin secretion ³⁶	11.39	REN EDN1 AGTR1 AGT ACE
8	HIF1Alpha Pathway ⁶³	11.37	NOS3 EPO EDN1
9	miRNA targets in ECM and membrane receptors ¹	11.21	MIR200B MIR200A MIR141
10	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Renin-angiotensin system ³⁶	11	REN NOS3 KNG1 AGTR1 AGT ACE
11	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶⁰	10.79	GPR182 DBH ADM

Sources

GO Terms for Renal Hypertension

Cellular components related to Renal Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	REN NPPB KNG1 KLKB1 EPO EDN1
2	blood microparticle	GO:0072562	9.46	KNG1 APOL1 ALB AGT
3	extracellular space	GO:0005615	9.44	REN NPPB MIR141 KNG1 KLKB1 EPO

Biological processes related to Renal Hypertension according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	10.01	MIR200B MIR141 EPO EDN1 AGT ADM
2	kidney development	GO:0001822	9.85	REN AGTR1 AGT ACE
3	response to lipopolysaccharide	GO:0032496	9.85	REN NOS3 EPO EDN1 ADM
4	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.8	KNG1 EDN1 AGTR1 AGT ADM
5	blood vessel remodeling	GO:0001974	9.67	NOS3 DBH AGT ACE
6	vasodilation	GO:0042311	9.65	NOS3 KNG1 AGT
7	positive regulation of cellular protein metabolic process	GO:0032270	9.63	AGTR1 AGT
8	amyloid-beta metabolic process	GO:0050435	9.63	REN ACE
9	positive regulation of urine volume	GO:0035810	9.62	NPPB EDN1
10	negative regulation of blood coagulation	GO:0030195	9.62	KNG1 EDN1
11	angiotensin maturation	GO:0002003	9.61	REN ACE
12	artery smooth muscle contraction	GO:0014824	9.61	EDN1 AGT
13	positive regulation of renal sodium excretion	GO:0035815	9.61	NPPB EDN1 AGT
14	response to dexamethasone	GO:0071548	9.6	EPO EDN1
15	positive regulation of cholesterol esterification	GO:0010873	9.59	AGTR1 AGT
16	body fluid secretion	GO:0007589	9.58	NPPB EDN1
17	positive regulation of NAD(P)H oxidase activity	GO:0033864	9.58	AGTR1 AGT
18	regulation of systemic arterial blood pressure by endothelin	GO:0003100	9.57	NOS3 EDN1
19	regulation of renal sodium excretion	GO:0035813	9.56	AGTR1 AGT
20	regulation of blood vessel diameter by renin-angiotensin	GO:0002034	9.52	AGTR1 AGT
21	regulation of renal output by angiotensin	GO:0002019	9.51	AGT ACE
22	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.5	AGTR1 AGT ACE
23	regulation of blood volume by renin-angiotensin	GO:0002016	9.49	REN AGT
24	regulation of blood vessel diameter	GO:0097746	9.46	NPPB NOS3 AGTR1 ACE
25	renin-angiotensin regulation of aldosterone production	GO:0002018	9.43	REN AGTR1 AGT
26	regulation of vasoconstriction	GO:0019229	9.26	EDN1 AGTR1 AGT ACE
27	regulation of blood pressure	GO:0008217	9.1	REN NPPB NOS3 EDN1 AGT ACE

Molecular functions related to Renal Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.55	REN NPPB KNG1 EDN1 ADM
2	hormone activity	GO:0005179	9.02	NPPB EPO EDN1 AGT ADM
3	bradykinin receptor binding	GO:0031711	8.96	AGTR1 ACE

Sources

Sources for Renal Hypertension

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia