MCID: RNL015
MIFTS: 46

Renal Hypertension

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases, Ear diseases, Genetic diseases

Aliases & Classifications for Renal Hypertension

MalaCards integrated aliases for Renal Hypertension:

Name: Renal Hypertension 12 76 15 73
Hypertension, Renal 44
Hypertension Renal 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1073
MeSH 44 D006977
NCIt 50 C3121
SNOMED-CT 68 194775007 28119000
UMLS 73 C0020544

Summaries for Renal Hypertension

MalaCards based summary : Renal Hypertension, also known as hypertension, renal, is related to renovascular hypertension and renal tuberculosis. An important gene associated with Renal Hypertension is EDN1 (Endothelin 1), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Renin secretion. The drugs Amlodipine and Atorvastatin Calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Renovascular hypertension (or \"renal hypertension\") is a condition in which high blood pressure is... more...

Related Diseases for Renal Hypertension

Diseases in the Renal Hypertension family:

Renal Failure, Progressive, with Hypertension

Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.4 ACE ADM AGTR1 EDN1 REN
2 renal tuberculosis 30.1 EDN1 REN
3 hypertensive encephalopathy 29.6 ACE EPO REN
4 arteriosclerosis 29.4 ACE ADM EDN1
5 diastolic heart failure 29.3 ACE AGTR1 NPPB
6 nephrosclerosis 28.4 ACE AGTR1
7 vascular disease 28.2 ACE ALB EDN1 KNG1 REN
8 malignant hypertension 27.9 ACE ADM AGTR1 EDN1 REN
9 kidney disease 27.5 ACE AGTR1 ALB EDN1 EPO NPPB
10 chronic kidney failure 27.1 ACE AGTR1 ALB EDN1 EPO NPPB
11 arteries, anomalies of 26.7 ACE AGTR1 ALB EDN1 KNG1 NPPB
12 hypertension, essential 22.7 ACE ADM AGTR1 ALB DBH EDN1
13 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome 12.4
14 malignant hypertensive renal disease 12.1
15 benign hypertensive renal disease 12.0
16 renal failure, progressive, with hypertension 11.1
17 polycystic kidney disease 4 with or without polycystic liver disease 10.8
18 polycystic kidney disease 3 with or without polycystic liver disease 10.8
19 chronic thromboembolic pulmonary hypertension 10.8 EDN1 NPPB
20 calciphylaxis 10.7 ALB EPO
21 malignant renovascular hypertension 10.7 EDN1 REN
22 constrictive pericarditis 10.7 ALB NPPB
23 splenic disease 10.7 ALB EPO
24 benign essential hypertension 10.7 ALB REN
25 perinephritis 10.7 EDN1 REN
26 kidney papillary necrosis 10.7 ALB REN
27 tricuspid valve insufficiency 10.7 ALB NPPB
28 chronic angina 10.7 NPPB REN
29 fetal erythroblastosis 10.7 ALB EPO
30 pure red-cell aplasia 10.7 ALB EPO
31 hypersplenism 10.6 ALB EPO
32 arthrogryposis, distal, type 3 10.6 REN SLC12A3
33 rh isoimmunization 10.6 ALB EPO
34 angina pectoris 10.6 ACE EDN1
35 cardiac tamponade 10.6 NPPB REN
36 hyporeninemic hypoaldosteronism 10.6 ACE REN
37 renal artery obstruction 10.6 ACE REN
38 hypoaldosteronism 10.6 ACE REN
39 secondary hyperparathyroidism of renal origin 10.5 ALB EPO
40 hypertensive retinopathy 10.5 ACE REN
41 hypertension, diastolic 10.5 ACE REN
42 aortic valve insufficiency 10.5 ACE NPPB
43 coronary artery vasospasm 10.5 EDN1 KNG1
44 analbuminemia 10.5 ALB EPO
45 diffuse scleroderma 10.5 EDN1 KNG1
46 atrial septal defect 4 10.5 ACE REN
47 ischemic heart disease 10.5 ACE NPPB
48 chronic mountain sickness 10.5 EDN1 EPO NPPB
49 raynaud phenomenon 10.5 AGTR1 EDN1
50 sexual disorder 10.5 ACE EDN1

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to Renal Hypertension

Symptoms & Phenotypes for Renal Hypertension

MGI Mouse Phenotypes related to Renal Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 KLKB1 REN SLC12A3 ACE ADM AGTR1
2 homeostasis/metabolism MP:0005376 9.65 KLKB1 REN SLC12A3 ACE ADM AGTR1
3 renal/urinary system MP:0005367 9.17 REN SLC12A3 ACE ADM AGTR1 ALB

Drugs & Therapeutics for Renal Hypertension

Drugs for Renal Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved 88150-42-9 2162
2 Atorvastatin Calcium 134523-03-8
3 calcium channel blockers
4 Amlodipine, atorvastatin drug combination
5 Vasodilator Agents
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors
7 Hypolipidemic Agents
8 Antihypertensive Agents
9 Anticholesteremic Agents
10 Lipid Regulating Agents
11 Antimetabolites
12 Calcium, Dietary

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety Recruiting NCT03541174 Phase 3 Aprocitentan 12.5 mg;Aprocitentan 25 mg;Placebo
2 Electroacupuncture for Hypertension Patients With Chronic Kidney Disease Completed NCT01766427
3 Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan) Completed NCT01107743 Amlodipine/Atorvastatin
4 Renal Denervation in Treatment Resistant Hypertension Recruiting NCT01687725
5 Renal Nerve Ablation in Chronic Kidney Disease Patients Recruiting NCT01442883
6 Prevalence of Resistant Hypertension With DOT Active, not recruiting NCT02513524

Search NIH Clinical Center for Renal Hypertension

Cochrane evidence based reviews: hypertension, renal

Genetic Tests for Renal Hypertension

Anatomical Context for Renal Hypertension

MalaCards organs/tissues related to Renal Hypertension:

41
Kidney, Heart, Brain, Testes, Endothelial, Smooth Muscle, Cortex

Publications for Renal Hypertension

Articles related to Renal Hypertension:

(show top 50) (show all 514)
# Title Authors Year
1
In renal hypertension, Cirsium japonicum strengthens cardiac function via the intermedin/nitric oxide pathway. ( 29525674 )
2018
2
Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. ( 29651418 )
2018
3
Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats. ( 26795298 )
2016
4
The cardioprotective effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. ( 25920277 )
2015
5
The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 25821295 )
2015
6
Hydroalcoholic extract of Allium eriophyllum leaves attenuates cardiac impairment in rats with simultaneous type 2 diabetes and renal hypertension. ( 26487889 )
2015
7
Curable renal hypertension: renin, marker or cause? Question answered. ( 25103928 )
2014
8
Editorial (thematic issue: all roads of renal hypertension lead to or come from CKD). ( 25549836 )
2014
9
Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. ( 25097277 )
2014
10
Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 24954237 )
2014
11
Renal hypertension and cardiovascular disorder in children with chronic kidney disease. ( 24684043 )
2014
12
Renal denervation for resistant hypertension using an irrigated radiofrequency balloon: 12-month results from the Renal Hypertension Ablation System (RHAS) trial. ( 23685297 )
2013
13
Renal hypertension: an unusual cause for a common problem. ( 23371394 )
2013
14
Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. ( 22458508 )
2012
15
ESPR uroradiology task force and ESUR paediatric working group: imaging recommendations in paediatric uroradiology, part IV: Minutes of the ESPR uroradiology task force mini-symposium on imaging in childhood renal hypertension and imaging of renal trauma in children. ( 21710387 )
2011
16
Effect of age and sex on blood pressure, development of renal hypertension, and concentration of nitric oxide in the blood of albino rats. ( 21113443 )
2010
17
Comprehensive evaluation of patients with suspected renal hypertension using MDCT: from protocol to interpretation. ( 19380531 )
2009
18
Effectiveness of unilateral nephrectomy for renal hypertension in adults. ( 19010760 )
2008
19
Total peripheral resistance responsiveness during the development of secondary renal hypertension in dogs. ( 17278982 )
2007
20
Cardiovascular reactivity of patients with essential and renal hypertension in an emotion-triggering interview. ( 17348427 )
2007
21
Renal capsular PEComa--a rare cause of surgically correctable renal hypertension. ( 17318350 )
2007
22
Cardiovascular reactivity in patients with essential or renal hypertension under standardized mental stress. ( 17653965 )
2007
23
Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. ( 16479187 )
2006
24
Ventricular structure and function in aged dogs with renal hypertension: a model of experimental diastolic heart failure. ( 15723971 )
2005
25
Water intake during the development of renal hypertension (2K-1C) in mice. ( 15992836 )
2005
26
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 15711357 )
2005
27
Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. ( 15126919 )
2004
28
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 14678186 )
2004
29
Mild renal hypertension alters run training effects on the frequency response of rat cardiomyocyte mechanics. ( 12857770 )
2003
30
[Clinical observation of the therapeutic effect of valsartan for renal hypertension in 64 cases]. ( 13129740 )
2003
31
The role of partial nephrectomy in the treatment of pediatric renal hypertension. ( 12544329 )
2003
32
Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. ( 12105374 )
2002
33
Neurohormonal influences on maintenance and reversal of two-kidney one-clip renal hypertension. ( 12100364 )
2002
34
Neurogenic factors in renal hypertension. ( 12003710 )
2002
35
Factors influencing acute ischaemia-induced renal hypertension in rats. ( 12473871 )
2002
36
Sympathetic nervous system function in renal hypertension. ( 12003706 )
2002
37
Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats. ( 11356766 )
2001
38
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. ( 11566905 )
2001
39
Altered contractions to endothelin-1, phenylephrine, potassium chloride and relaxations to acetylcholine at various stages of renal hypertension in the rat. ( 11401413 )
2001
40
Plasma-levels of endothelin-1 and angiotensin-II and reactivity of arterial blood pressure to exogenous sympathomimetics and vasoactive peptides in rat model of malignant renal hypertension. ( 10870254 )
2000
41
Plasma brain natriuretic peptides and renal hypertension. ( 10955934 )
2000
42
[The protection of renal function in the ACEI treatment of renal hypertension]. ( 12206011 )
2000
43
Effect of ramipril on ambulatory blood pressure and albuminuria in renal hypertension. ( 11095026 )
2000
44
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. ( 10706380 )
2000
45
Poland's syndrome--complicated with renal hypertension. ( 11273191 )
2000
46
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension. ( 11105103 )
2000
47
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. ( 10666094 )
2000
48
Serial magnetic resonance imaging of rat brain after induction of renal hypertension. ( 10548682 )
1999
49
[Study on the relationship between plasma endothelin nitric oxide concentration and renal hypertension and renal function]. ( 12080656 )
1999
50
Decreased diurnal blood pressure variability and low dehydroepiandrosterone sulfate levels in patients with renal hypertension, and after kidney transplantation. ( 10463206 )
1999

Variations for Renal Hypertension

Expression for Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for Renal Hypertension

GO Terms for Renal Hypertension

Cellular components related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ACE ADM ALB DBH EDN1 EPO
2 extracellular space GO:0005615 9.32 ACE ADM ALB DBH EDN1 EPO

Biological processes related to Renal Hypertension according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 ADM EDN1 EPO NPPB
2 response to hypoxia GO:0001666 9.77 ADM EDN1 EPO
3 response to lipopolysaccharide GO:0032496 9.71 ADM EDN1 EPO REN
4 kidney development GO:0001822 9.69 ACE AGTR1 REN
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 ADM AGTR1 EDN1 KNG1
6 response to testosterone GO:0033574 9.61 EDN1 EPO
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.61 AGTR1 EDN1
8 blood vessel remodeling GO:0001974 9.6 ACE DBH
9 positive regulation of heart rate GO:0010460 9.58 ADM EDN1
10 blood coagulation, intrinsic pathway GO:0007597 9.57 KLKB1 KNG1
11 negative regulation of blood coagulation GO:0030195 9.56 EDN1 KNG1
12 positive regulation of renal sodium excretion GO:0035815 9.55 EDN1 NPPB
13 amyloid-beta metabolic process GO:0050435 9.54 ACE REN
14 positive regulation of urine volume GO:0035810 9.52 EDN1 NPPB
15 angiotensin maturation GO:0002003 9.49 ACE REN
16 response to dexamethasone GO:0071548 9.48 EDN1 EPO
17 body fluid secretion GO:0007589 9.46 EDN1 NPPB
18 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGTR1
19 regulation of vasoconstriction GO:0019229 9.43 ACE AGTR1 EDN1
20 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGTR1 REN
21 regulation of blood vessel size GO:0050880 9.33 EDN1 KNG1 NPPB
22 regulation of blood vessel diameter GO:0097746 9.13 ACE AGTR1 NPPB
23 regulation of blood pressure GO:0008217 8.92 ACE EDN1 NPPB REN

Molecular functions related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 ADM EDN1 KNG1 NPPB REN
2 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
3 hormone activity GO:0005179 8.92 ADM EDN1 EPO NPPB

Sources for Renal Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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