MCID: RNL015
MIFTS: 50

Renal Hypertension

Categories: Cardiovascular diseases, Ear diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Hypertension

MalaCards integrated aliases for Renal Hypertension:

Name: Renal Hypertension 12 76 15 73
Hypertension, Renal 44
Hypertension Renal 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1073
MeSH 44 D006977
NCIt 50 C3121
SNOMED-CT 68 28119000
UMLS 73 C0020544

Summaries for Renal Hypertension

MalaCards based summary : Renal Hypertension, also known as hypertension, renal, is related to malignant hypertensive renal disease and renovascular hypertension. An important gene associated with Renal Hypertension is EDN1 (Endothelin 1), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Renin secretion. The drugs Amlodipine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Renovascular hypertension (or "renal hypertension") is a condition in which high blood pressure is... more...

Related Diseases for Renal Hypertension

Diseases in the Renal Hypertension family:

Renal Failure, Progressive, with Hypertension

Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 malignant hypertensive renal disease 33.8 EDN1 REN
2 renovascular hypertension 31.0 REN EDN1 AGTR1 ADM ACE
3 benign essential hypertension 29.7 ALB REN
4 arteriosclerosis 29.6 ACE ADM EDN1
5 renal tuberculosis 29.6 EDN1 REN
6 vascular disease 29.5 ACE ALB EDN1 KNG1 REN
7 pulmonary hypertension, primary, 1 29.5 ADM EDN1 NPPB
8 hypertensive encephalopathy 29.5 ACE EPO REN
9 ischemia 29.4 ACE EDN1 EPO KNG1
10 microvascular complications of diabetes 3 29.4 ACE AGTR1 ALB
11 pheochromocytoma 29.4 ADM DBH KNG1 REN
12 diastolic heart failure 29.4 ACE AGTR1 NPPB
13 renal tubular dysgenesis 29.3 ACE AGTR1 REN
14 familial hypertension 29.3 AGTR1 REN
15 pulmonary hypertension 29.3 ACE ADM EDN1 NPPB REN
16 renal artery disease 29.2 ACE AGTR1 EPO REN
17 nephrosclerosis 29.1 ACE AGTR1
18 malignant hypertension 28.9 REN EDN1 AGTR1 ADM ACE
19 malignant essential hypertension 28.9 ACE KLKB1 KNG1 REN
20 kidney disease 28.9 REN NPPB EPO EDN1 ALB AGTR1
21 diabetes mellitus 28.9 ACE AGTR1 ALB EDN1 EPO REN
22 chronic kidney failure 28.7 REN NPPB EPO EDN1 ALB AGTR1
23 arteries, anomalies of 28.6 REN NPPB KNG1 EDN1 ALB AGTR1
24 congestive heart failure 28.3 REN NPPB KNG1 EPO EDN1 AGTR1
25 hypertension, essential 27.3 SLC12A3 REN NPPB KNG1 KLKB1 EDN1
26 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome 12.6
27 benign hypertensive renal disease 12.2
28 renal failure, progressive, with hypertension 11.2
29 polycystic kidney disease 4 with or without polycystic liver disease 10.9
30 polycystic kidney disease 3 with or without polycystic liver disease 10.9
31 chronic thromboembolic pulmonary hypertension 10.2 EDN1 NPPB
32 malignant renovascular hypertension 10.2 EDN1 REN
33 calciphylaxis 10.2 ALB EPO
34 constrictive pericarditis 10.2 ALB NPPB
35 splenic disease 10.2 ALB EPO
36 tricuspid valve insufficiency 10.2 ALB NPPB
37 kidney papillary necrosis 10.2 ALB REN
38 fetal erythroblastosis 10.2 ALB EPO
39 perinephritis 10.2 EDN1 REN
40 loeffler syndrome 10.2 ACE ALB
41 chronic angina 10.2 NPPB REN
42 pure red-cell aplasia 10.2 ALB EPO
43 hypersplenism 10.2 ALB EPO
44 rh isoimmunization 10.2 ALB EPO
45 arthrogryposis, distal, type 3 10.2 REN SLC12A3
46 cardiac tamponade 10.2 NPPB REN
47 hyporeninemic hypoaldosteronism 10.2 ACE REN
48 hypoaldosteronism 10.2 ACE REN
49 anterolateral myocardial infarction 10.2 ACE NPPB
50 secondary hyperparathyroidism of renal origin 10.2 ALB EPO

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to Renal Hypertension

Symptoms & Phenotypes for Renal Hypertension

MGI Mouse Phenotypes related to Renal Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ACE ADM AGTR1 DBH EDN1 EPO
2 homeostasis/metabolism MP:0005376 9.65 ACE ADM AGTR1 ALB DBH EDN1
3 renal/urinary system MP:0005367 9.17 ACE ADM AGTR1 ALB EDN1 REN

Drugs & Therapeutics for Renal Hypertension

Drugs for Renal Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved 88150-42-9 2162
2 Vasodilator Agents
3 Atorvastatin Calcium 134523-03-8
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors
5 Hypolipidemic Agents
6 Calcium, Dietary
7 calcium channel blockers
8 Anticholesteremic Agents
9 Antimetabolites
10 Amlodipine, atorvastatin drug combination
11 Antihypertensive Agents
12 Lipid Regulating Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety Recruiting NCT03541174 Phase 3 Aprocitentan 12.5 mg;Aprocitentan 25 mg;Placebo
2 Electroacupuncture for Hypertension Patients With Chronic Kidney Disease Completed NCT01766427
3 Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan) Completed NCT01107743 Amlodipine/Atorvastatin
4 Renal Denervation in Treatment Resistant Hypertension Recruiting NCT01687725
5 Renal Nerve Ablation in Chronic Kidney Disease Patients Recruiting NCT01442883
6 Prevalence of Resistant Hypertension With DOT Active, not recruiting NCT02513524

Search NIH Clinical Center for Renal Hypertension

Cochrane evidence based reviews: hypertension, renal

Genetic Tests for Renal Hypertension

Anatomical Context for Renal Hypertension

MalaCards organs/tissues related to Renal Hypertension:

41
Kidney, Testes, Endothelial, Liver, Heart, Brain, Cortex

Publications for Renal Hypertension

Articles related to Renal Hypertension:

(show top 50) (show all 947)
# Title Authors Year
1
In renal hypertension, Cirsium japonicum strengthens cardiac function via the intermedin/nitric oxide pathway. ( 29525674 )
2018
2
Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. ( 29651418 )
2018
3
Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner. ( 28811528 )
2017
4
Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats. ( 26795298 )
2016
5
Association between Body Mass Index, Waist Circumference and Prevalence of Microalbuminuria in Korean Adults of Age 30 Years and Older without Diabetes, Hypertension, Renal Failure, or Overt Proteinuria: The 2013 Korean National Health and Nutrition Examination Survey. ( 26885324 )
2016
6
Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy. ( 26923216 )
2016
7
The cardioprotective effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. ( 25920277 )
2015
8
The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 25821295 )
2015
9
Hydroalcoholic extract of Allium eriophyllum leaves attenuates cardiac impairment in rats with simultaneous type 2 diabetes and renal hypertension. ( 26487889 )
2015
10
Curable renal hypertension: renin, marker or cause? Question answered. ( 25103928 )
2014
11
Editorial (thematic issue: all roads of renal hypertension lead to or come from CKD). ( 25549836 )
2014
12
Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. ( 25097277 )
2014
13
Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 24954237 )
2014
14
Renal hypertension and cardiovascular disorder in children with chronic kidney disease. ( 24684043 )
2014
15
Renal denervation for resistant hypertension using an irrigated radiofrequency balloon: 12-month results from the Renal Hypertension Ablation System (RHAS) trial. ( 23685297 )
2013
16
Renal hypertension: an unusual cause for a common problem. ( 23371394 )
2013
17
Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. ( 22458508 )
2012
18
ESPR uroradiology task force and ESUR paediatric working group: imaging recommendations in paediatric uroradiology, part IV: Minutes of the ESPR uroradiology task force mini-symposium on imaging in childhood renal hypertension and imaging of renal trauma in children. ( 21710387 )
2011
19
A rare clinical syndrome of refractory secondary hypertension, renal artery stenosis and erythrocytosis. ( 25984150 )
2011
20
Effect of age and sex on blood pressure, development of renal hypertension, and concentration of nitric oxide in the blood of albino rats. ( 21113443 )
2010
21
Perioperative hemodynamics obtained by pulse contour analysis facilitated the management of a patient with chronic hypertension, renal insufficiency, and superimposed preeclampsia during cesarean delivery. ( 20522358 )
2010
22
Long term risk for hypertension, renal impairment, and cardiovascular disease after gastroenteritis from drinking water contaminated with Escherichia coli O157:H7: a prospective cohort study. ( 21084368 )
2010
23
Comprehensive evaluation of patients with suspected renal hypertension using MDCT: from protocol to interpretation. ( 19380531 )
2009
24
Effectiveness of unilateral nephrectomy for renal hypertension in adults. ( 19010760 )
2008
25
Total peripheral resistance responsiveness during the development of secondary renal hypertension in dogs. ( 17278982 )
2007
26
Cardiovascular reactivity of patients with essential and renal hypertension in an emotion-triggering interview. ( 17348427 )
2007
27
Renal capsular PEComa--a rare cause of surgically correctable renal hypertension. ( 17318350 )
2007
28
Cardiovascular reactivity in patients with essential or renal hypertension under standardized mental stress. ( 17653965 )
2007
29
A patient with suspected miscarriage is found to have hypertension, renal failure, and thrombocytopenia: case outcome. ( 17656546 )
2007
30
Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. ( 16479187 )
2006
31
Role of uric acid in hypertension, renal disease, and metabolic syndrome. ( 17190309 )
2006
32
Ventricular structure and function in aged dogs with renal hypertension: a model of experimental diastolic heart failure. ( 15723971 )
2005
33
Water intake during the development of renal hypertension (2K-1C) in mice. ( 15992836 )
2005
34
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 15711357 )
2005
35
Nephron number, hypertension, renal disease, and renal failure. ( 16049069 )
2005
36
Hypertension, renal disease, and cardiovascular outcomes. ( 16103759 )
2005
37
Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. ( 15126919 )
2004
38
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 14678186 )
2004
39
An infant with systemic hypertension, renal artery stenosis, and neuroblastoma. ( 14694383 )
2004
40
Hypertension, renal disease, and drug considerations. ( 15470296 )
2004
41
Mild renal hypertension alters run training effects on the frequency response of rat cardiomyocyte mechanics. ( 12857770 )
2003
42
[Clinical observation of the therapeutic effect of valsartan for renal hypertension in 64 cases]. ( 13129740 )
2003
43
The role of partial nephrectomy in the treatment of pediatric renal hypertension. ( 12544329 )
2003
44
Association of region of residence and immigrant status with hypertension, renal failure, cardiovascular disease, and stroke, among African-American participants in the third National Health and Nutrition Examination Survey (NHANES III). ( 12894955 )
2003
45
Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. ( 12105374 )
2002
46
Neurohormonal influences on maintenance and reversal of two-kidney one-clip renal hypertension. ( 12100364 )
2002
47
Neurogenic factors in renal hypertension. ( 12003710 )
2002
48
Factors influencing acute ischaemia-induced renal hypertension in rats. ( 12473871 )
2002
49
Sympathetic nervous system function in renal hypertension. ( 12003706 )
2002
50
Roundtable discussion: hypertension, renal disease, and diabetes. ( 11944621 )
2002

Variations for Renal Hypertension

Expression for Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for Renal Hypertension

GO Terms for Renal Hypertension

Cellular components related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ACE ADM ALB DBH EDN1 EPO
2 extracellular space GO:0005615 9.32 ACE ADM ALB DBH EDN1 EPO

Biological processes related to Renal Hypertension according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 ADM EDN1 EPO NPPB
2 response to hypoxia GO:0001666 9.77 ADM EDN1 EPO
3 kidney development GO:0001822 9.69 ACE AGTR1 REN
4 response to lipopolysaccharide GO:0032496 9.67 ADM EDN1 EPO REN
5 blood circulation GO:0008015 9.62 ADM EPO
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 ADM AGTR1 EDN1 KNG1
7 response to testosterone GO:0033574 9.61 EDN1 EPO
8 blood vessel remodeling GO:0001974 9.61 ACE DBH
9 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.6 AGTR1 EDN1
10 positive regulation of heart rate GO:0010460 9.58 ADM EDN1
11 blood coagulation, intrinsic pathway GO:0007597 9.57 KLKB1 KNG1
12 negative regulation of blood coagulation GO:0030195 9.56 EDN1 KNG1
13 amyloid-beta metabolic process GO:0050435 9.55 ACE REN
14 positive regulation of renal sodium excretion GO:0035815 9.54 EDN1 NPPB
15 positive regulation of urine volume GO:0035810 9.52 EDN1 NPPB
16 response to dexamethasone GO:0071548 9.49 EDN1 EPO
17 angiotensin maturation GO:0002003 9.48 ACE REN
18 body fluid secretion GO:0007589 9.46 EDN1 NPPB
19 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGTR1
20 regulation of vasoconstriction GO:0019229 9.43 ACE AGTR1 EDN1
21 renin-angiotensin regulation of aldosterone production GO:0002018 9.4 AGTR1 REN
22 regulation of blood vessel size GO:0050880 9.33 EDN1 KNG1 NPPB
23 regulation of blood vessel diameter GO:0097746 9.13 ACE AGTR1 NPPB
24 regulation of blood pressure GO:0008217 8.92 ACE EDN1 NPPB REN

Molecular functions related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 ADM EDN1 KNG1 NPPB REN
2 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
3 hormone activity GO:0005179 8.92 ADM EDN1 EPO NPPB

Sources for Renal Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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