MCID: RNL016
MIFTS: 27

Renal Infectious Disease

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Renal Infectious Disease

MalaCards integrated aliases for Renal Infectious Disease:

Name: Renal Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:782
ICD9CM 34 590
SNOMED-CT 67 266618004
ICD10 32 N15.9
UMLS 70 C0021313

Summaries for Renal Infectious Disease

MalaCards based summary : Renal Infectious Disease is related to autoinflammatory syndrome and congenital toxoplasmosis. An important gene associated with Renal Infectious Disease is NLRP1 (NLR Family Pyrin Domain Containing 1), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. Related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Renal Infectious Disease

Diseases in the Kidney Disease family:

Acute Kidney Failure Renal Infectious Disease
Chronic Kidney Disease Ren-Related Kidney Disease

Diseases related to Renal Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 autoinflammatory syndrome 10.3 NLRP3 NLRC4
2 congenital toxoplasmosis 10.2 NLRP1 IL18
3 mycobacterium kansasii 10.1 TLR2 NLRP3
4 pneumonic tularemia 10.1 TLR2 AIM2
5 mycobacterium abscessus 10.1 TLR2 NLRP3
6 cryopyrin-associated periodic syndrome 10.1 NLRP3 CRP
7 optic papillitis 10.1 NLRP3 CRP
8 uremic pruritus 10.1 IL18 CRP
9 physical urticaria 10.1 NLRP3 CRP
10 chronic meningitis 10.0 NLRP3 CRP
11 papilledema 10.0 NLRP3 CRP
12 prosthetic joint infection 10.0 TLR2 CRP
13 blau syndrome 10.0 TLR2 NLRP3 NLRC4
14 genital herpes 10.0 TLR2 IL18
15 necrotizing fasciitis 10.0 IL18 CRP
16 vulvovaginal candidiasis 10.0 TLR2 NLRP3
17 salpingitis 10.0 TLR2 CRP
18 listeriosis 10.0 TLR2 IL18 AIM2
19 suppurative otitis media 10.0 TLR2 CRP
20 chlamydia pneumonia 9.9 TLR2 CRP
21 urethritis 9.9 TLR2 CRP
22 blood group, globoside system 9.9 TLR2 CRP
23 familial cold autoinflammatory syndrome 1 9.9 NLRP3 CASP1
24 gout 9.9 PYCARD NLRP3 IL18
25 pericardium disease 9.9 IL18 CRP
26 primary systemic mycosis 9.9 TLR2 CRP
27 macrophage activation syndrome 9.9 NLRC4 IL18 CRP
28 aphthous stomatitis 9.9 TLR2 NLRP3 IL18
29 klebsiella pneumonia 9.9 TLR2 CRP
30 cervical adenitis 9.9 NLRP3 CRP CARD8
31 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 9.9 NLRP3 CASP1
32 pharyngitis 9.9 NLRP3 CRP CARD8
33 endophthalmitis 9.9 TLR2 CRP
34 anthrax disease 9.9 NLRP1 CASP1
35 pyelitis 9.9 TLR2 CRP
36 fallopian tube disease 9.9 TLR2 CRP
37 adult-onset still's disease 9.9 NLRP3 IL18 CRP
38 exanthem 9.9 NLRP3 IL18 CRP
39 wells syndrome 9.9 PYCARD NLRP3 CRP
40 gingival disease 9.9 TLR2 CRP
41 urticaria 9.8 NLRP3 IL18 CRP
42 vaginal disease 9.8 TLR2 CRP
43 autoinflammation with arthritis and dyskeratosis 9.8 NLRP1 IL18 CASP1
44 marginal corneal ulcer 9.8 CRP CASP1
45 sebaceous gland disease 9.8 TLR2 NLRP3 CRP
46 chronic spontaneous urticaria 9.8 IL18 CRP
47 endocardium disease 9.8 TLR2 CRP
48 bacteriuria 9.8 TLR2 IL18 CRP
49 scrub typhus 9.8 TLR2 IL18 CRP
50 mycoplasma pneumoniae pneumonia 9.8 TLR2 IL18 CRP

Graphical network of the top 20 diseases related to Renal Infectious Disease:



Diseases related to Renal Infectious Disease

Symptoms & Phenotypes for Renal Infectious Disease

GenomeRNAi Phenotypes related to Renal Infectious Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 CASP1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 CASP1 IL18 NLRC4 NLRP1 NLRP3 PYCARD
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 CARD8 IL18 NLRP1 NLRP3 PYCARD
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 CARD8 CASP1 IL18 NLRP1 NLRP3 PYCARD

MGI Mouse Phenotypes related to Renal Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 AIM2 CASP1 IL18 NLRC4 NLRP1 NLRP3
2 homeostasis/metabolism MP:0005376 9.65 AIM2 BGN CASP1 CRP IL18 NLRC4
3 immune system MP:0005387 9.32 AIM2 BGN CASP1 CRP IL18 NLRC4

Drugs & Therapeutics for Renal Infectious Disease

Search Clinical Trials , NIH Clinical Center for Renal Infectious Disease

Genetic Tests for Renal Infectious Disease

Anatomical Context for Renal Infectious Disease

Publications for Renal Infectious Disease

Articles related to Renal Infectious Disease:

# Title Authors PMID Year
1
Is serum CRP level a reliable inflammatory marker in pediatric nephrotic syndrome? 61
26956466 2016
2
[Ultrasound assessment in renal infections]. 61
23229529 2012
3
Diffusion-weighted MR imaging in the evaluation of renal infection: preliminary results. 61
12083620 2002
4
[Xanthogranulomatous pyelonephritis]. 61
11832078 2000

Variations for Renal Infectious Disease

Expression for Renal Infectious Disease

Search GEO for disease gene expression data for Renal Infectious Disease.

Pathways for Renal Infectious Disease

Pathways related to Renal Infectious Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 TLR2 PYCARD NLRP3 NLRP1 NLRC4 IL18
2
Show member pathways
12.96 TLR2 PYCARD NLRP3 IL18 CASP1
3
Show member pathways
12.6 TLR2 PYCARD NLRP3 IL18 CASP1
4
Show member pathways
12.53 TLR2 PYCARD NLRP3 NLRC4 IL18 CASP1
5
Show member pathways
12.5 TLR2 PYCARD NLRP3 NLRP1 NLRC4 IL18
6
Show member pathways
12.35 PYCARD IL18 CASP1 AIM2
7 12.22 PYCARD NLRP3 NLRC4 IL18 CASP1
8
Show member pathways
12 PYCARD NLRP3 CASP1
9
Show member pathways
11.98 PYCARD NLRP3 CASP1
10 11.9 PYCARD NLRP3 NLRC4 IL18 CASP1
11 11.85 PYCARD NLRC4 CASP1
12 11.82 PYCARD NLRP3 NLRP1 NLRC4 IL18 CASP1
13
Show member pathways
11.69 PYCARD NLRP3 NLRP1 NLRC4 CASP1 AIM2
14 11.58 PYCARD NLRP3 CASP1
15 11.41 TLR2 PYCARD NLRC4 IL18 CASP1
16 11.05 TLR2 NLRP3 IL18
17 10.98 NLRP1 IL18 CASP1
18 10.84 PYCARD NLRP3 NLRP1 NLRC4 IL18 CASP1
19 10.38 IL18 CASP1

GO Terms for Renal Infectious Disease

Cellular components related to Renal Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammasome complex GO:0061702 9.43 NLRP3 NLRP1 CARD8
2 AIM2 inflammasome complex GO:0097169 9.33 PYCARD CASP1 AIM2
3 IPAF inflammasome complex GO:0072557 9.32 NLRC4 CASP1
4 NLRP1 inflammasome complex GO:0072558 9.13 PYCARD NLRP1 CASP1
5 NLRP3 inflammasome complex GO:0072559 8.92 PYCARD NLRP3 CASP1 CARD8

Biological processes related to Renal Infectious Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 TLR2 PYCARD NLRP3 NLRP1 NLRC4 AIM2
2 innate immune response GO:0045087 9.95 TLR2 PYCARD NLRP3 NLRP1 NLRC4 CRP
3 regulation of apoptotic process GO:0042981 9.88 PYCARD NLRP1 NLRC4 CASP1 CARD8
4 apoptotic process GO:0006915 9.86 TLR2 PYCARD NLRP3 NLRP1 NLRC4 CASP1
5 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 PYCARD NLRP1 NLRC4 CASP1 CARD8
6 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.76 PYCARD NLRP3 CARD8 AIM2
7 cellular response to lipopolysaccharide GO:0071222 9.74 PYCARD NLRP3 CASP1
8 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.73 PYCARD NLRP3 CASP1 CARD8
9 regulation of inflammatory response GO:0050727 9.72 PYCARD NLRP1 CASP1
10 activation of innate immune response GO:0002218 9.67 PYCARD NLRC4 AIM2
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 TLR2 PYCARD NLRP3 NLRC4 IL18 AIM2
12 pyroptosis GO:0070269 9.62 NLRP1 NLRC4 CASP1 AIM2
13 positive regulation of chemokine production GO:0032722 9.61 TLR2 PYCARD
14 positive regulation of interleukin-10 production GO:0032733 9.6 TLR2 PYCARD
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 TLR2 IL18
16 positive regulation of defense response to virus by host GO:0002230 9.58 PYCARD AIM2
17 positive regulation of activated T cell proliferation GO:0042104 9.58 PYCARD IL18
18 activation of cysteine-type endopeptidase activity GO:0097202 9.56 PYCARD NLRC4
19 inflammatory response GO:0006954 9.56 TLR2 PYCARD NLRP3 NLRP1 NLRC4 IL18
20 positive regulation of cysteine-type endopeptidase activity GO:2001056 9.54 PYCARD AIM2
21 positive regulation of T-helper 2 cell differentiation GO:0045630 9.52 NLRP3 IL18
22 positive regulation of interleukin-1 beta production GO:0032731 9.17 PYCARD NLRP3 NLRP1 NLRC4 CASP1 CARD8

Molecular functions related to Renal Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TLR2 PYCARD NLRP3 NLRC4 CRP CASP1
2 peptidoglycan binding GO:0042834 9.32 TLR2 NLRP3
3 CARD domain binding GO:0050700 9.26 CASP1 CARD8
4 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.16 PYCARD CASP1
5 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 8.92 PYCARD NLRP1 CASP1 CARD8

Sources for Renal Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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