MCID: RNL017
MIFTS: 48

Renal Oncocytoma

Categories: Rare diseases, Nephrological diseases, Cancer diseases, Genetic diseases

Aliases & Classifications for Renal Oncocytoma

MalaCards integrated aliases for Renal Oncocytoma:

Name: Renal Oncocytoma 38 12 53 15
Oncocytoma, Renal 44 73
Renal Epithelial Oncocytic Tumor 12
Oncocytoma of Kidney 12
Oncocytoma Kidney 53
Oncocytoma Renal 53

Classifications:



External Ids:

Disease Ontology 12 DOID:6245
MeSH 44 C537750
NCIt 50 C4526
SNOMED-CT 68 254922006
UMLS 73 C0346255

Summaries for Renal Oncocytoma

NIH Rare Diseases : 53 Renal oncocytoma is a benign (noncancerous) growth of the kidney. They generally do not cause any signs or symptoms and are often discovered incidentally (by chance) while a person is undergoing diagnostic imaging for other conditions. Some people with renal oncocytoma will have abdominal or flank pain; blood in the urine; and/or an abdominal mass. Although these tumors can occur in people of all ages, they most commonly develop in men who are over age 50. The exact underlying cause of most isolated (single tumor affecting one kidney) renal oncocytomas is unknown; however, multiple and bilateral (affecting both kidneys) renal oncocytomas sometimes occur in people with certain genetic syndromes such as tuberous sclerosis complex and Birt-Hogg-Dube syndrome. Although many benign tumors do not require treatment unless they are causing unpleasant symptoms, it can be difficult to confidently differentiate a renal oncocytoma from renal cell carcinoma. Most affected people are, therefore, treated with surgery which allows for confirmation of the diagnosis.

MalaCards based summary : Renal Oncocytoma, also known as oncocytoma, renal, is related to clear cell renal cell carcinoma and oncocytoma. An important gene associated with Renal Oncocytoma is CLDN8 (Claudin 8), and among its related pathways/superpathways is Dendritic Cells Developmental Lineage Pathway. The drugs Technetium Tc 99m Sestamibi and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and brain, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 76 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of... more...

Related Diseases for Renal Oncocytoma

Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 clear cell renal cell carcinoma 30.3 FLCN KRT7 MME
2 oncocytoma 30.0 CAV1 CDH16 CLDN8 FLCN KIT KRT7
3 renal cell carcinoma, papillary, 1 29.1 CDH16 FLCN KIT KRT7 MME
4 chromophobe renal cell carcinoma 28.6 CDH16 CLDN8 EPCAM FLCN KIT KRT7
5 renal cell carcinoma, nonpapillary 27.3 CDH16 CLDN8 EPCAM FLCN KIT KRT7
6 familial renal oncocytoma 12.3
7 birt-hogg-dube syndrome 11.0
8 jejunal cancer 10.7 KIT KRT7
9 cribriform carcinoma 10.7 KIT KRT7
10 malignant mixed mullerian tumor 10.7 KIT KRT7
11 adenoid basal cell carcinoma 10.6 KIT KRT7
12 intratubular embryonal carcinoma 10.6 KIT KRT7
13 pleomorphic carcinoma 10.6 KIT KRT7
14 balloon cell malignant melanoma 10.6 KRT7 MME
15 cervical adenoma malignum 10.6 KRT7 MME
16 cervical mucinous adenocarcinoma 10.6 KRT7 MME
17 clear cell papillary renal cell carcinoma 10.6 KRT7 MME
18 bladder lymphoma 10.6 KRT7 MME
19 adenomyoma 10.6 KRT7 MME
20 dermoid cyst 10.6 KIT KRT7
21 benign breast phyllodes tumor 10.5 KIT MME
22 rete testis adenocarcinoma 10.5 KIT MME
23 cystic nephroma 10.5 KIT MME
24 breast adenomyoepithelioma 10.5 KRT7 MME
25 perivascular epithelioid cell tumor 10.5 KIT MME
26 necrotizing sialometaplasia 10.5 KIT KRT7
27 papillary hidradenoma 10.5 KIT MME
28 breast myoepithelial neoplasm 10.5 KRT7 MME
29 mucinous tubular and spindle renal cell carcinoma 10.5 KRT7 MME
30 large cell neuroendocrine carcinoma 10.5 KIT KRT7
31 malignant biphasic mesothelioma 10.5 EPCAM KRT7
32 adenosarcoma 10.5 KIT MME
33 infiltrative basal cell carcinoma 10.5 KRT7 MME
34 spindle cell synovial sarcoma 10.5 KIT KRT7
35 rete testis neoplasm 10.5 KIT MME
36 collecting duct carcinoma 10.5 KRT7 MME
37 cystadenofibroma 10.4 KRT7 MME
38 pancreatic mucinous cystadenoma 10.4 KRT7 MME
39 nephrogenic adenofibroma 10.4 KRT7 MME
40 gastrointestinal system benign neoplasm 10.3 KIT KRT7
41 bile duct adenocarcinoma 10.3 EPCAM KRT7
42 uterine sarcoma 10.3 KIT MME
43 malignant leydig cell tumor 10.2 KIT KRT7 MME
44 cystadenoma 10.2 KRT7 MME
45 mixed cell type cancer 10.2 KIT KRT7 MME
46 papillary adenocarcinoma 10.2 KRT7 MST1R
47 ovarian brenner tumor 10.2 KIT KRT7 MME
48 organ system benign neoplasm 10.2 KIT KRT7 MME
49 gastrointestinal system cancer 10.1 EPCAM KIT KRT7
50 spindle cell carcinoma 10.1 CDH16 KRT7

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to Renal Oncocytoma

Symptoms & Phenotypes for Renal Oncocytoma

MGI Mouse Phenotypes related to Renal Oncocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 CAV1 CLDN8 EPCAM FLCN KIT KRT7
2 renal/urinary system MP:0005367 9.1 CAV1 CLDN8 FLCN KIT KRT7 SDHB

Drugs & Therapeutics for Renal Oncocytoma

Drugs for Renal Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Technetium Tc 99m Sestamibi Not Applicable
2 Radiopharmaceuticals Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Active, not recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride
2 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Recruiting NCT02160925 Not Applicable
3 Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer Terminated NCT00491621 Not Applicable

Search NIH Clinical Center for Renal Oncocytoma

Cochrane evidence based reviews: oncocytoma, renal

Genetic Tests for Renal Oncocytoma

Anatomical Context for Renal Oncocytoma

MalaCards organs/tissues related to Renal Oncocytoma:

41
Kidney, T Cells, Brain, Prostate, Liver, Testis, Thyroid

Publications for Renal Oncocytoma

Articles related to Renal Oncocytoma:

(show top 50) (show all 379)
# Title Authors Year
1
Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. ( 29353061 )
2018
2
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? ( 29970253 )
2018
3
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. ( 29915083 )
2018
4
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29738030 )
2018
5
Contemporary Surgical Management of Renal Oncocytoma: A nation's outcome. ( 29397002 )
2018
6
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. ( 29752278 )
2018
7
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. ( 29796579 )
2018
8
Re: The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. ( 29370653 )
2017
9
Liver Metastases From Renal Oncocytoma With Vascular Extension. ( 28682831 )
2017
10
Modern Pathologic Diagnosis of Renal Oncocytoma. ( 29090117 )
2017
11
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione. ( 29285300 )
2017
12
Giant renal oncocytoma with classic stellate scar. ( 28130290 )
2017
13
Remote Development of Tumor-to-Tumor Metastasis of Breast Adenocarcinoma in a Renal Oncocytoma. ( 28551171 )
2017
14
Renal oncocytoma in a cat with chronic renal failure. ( 28491452 )
2017
15
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-I^-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma. ( 28668830 )
2017
16
A systematic review and meta-analysis of immunohistochemical biomarkers that differentiate chromophobe renal cell carcinoma from renal oncocytoma. ( 26951082 )
2016
17
Renal Oncocytoma With Perinephric Fat Invasion. ( 27170678 )
2016
18
Renal oncocytoma, small cell variant, with pseudorosettes, showing cyclin D1 expression and tubulovesicular cristae of mitochondria. ( 27076064 )
2016
19
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ( 26670126 )
2016
20
Active surveillance is suitable for intermediate term follow-up of renal oncocytoma diagnosed by percutaneous core biopsy. ( 27457972 )
2016
21
Bladder leiomyoma in male patient presenting with renal oncocytoma: Are the two conditions related? ( 27453673 )
2016
22
Renal Oncocytoma with Vascular Invasion: A Series of 22 Cases. ( 27498062 )
2016
23
Renal oncocytoma: A report of two cases and review of the literature. ( 27347140 )
2016
24
Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. ( 27595574 )
2016
25
HNF1I^ and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies. ( 25739652 )
2015
26
Comparative study of CT appearances in renal oncocytoma and chromophobe renal cell carcinoma. ( 25972369 )
2015
27
Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dube tumors. ( 26428318 )
2015
28
DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. ( 25596994 )
2015
29
Differentiation of renal oncocytoma and renal clear cell carcinoma using relative CT enhancement ratio. ( 25591558 )
2015
30
Supremacy of modern morphometry in typing renal oncocytoma and malignant look-alikes. ( 25929744 )
2015
31
Cystic Renal Oncocytoma and Tubulocystic Renal Cell Carcinoma: Morphologic and Immunohistochemical Comparative Study. ( 26180933 )
2015
32
The clinicopathological, ultrastructural, genetic features and diagnosis of small cell variant renal oncocytoma. ( 25935740 )
2015
33
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. ( 26655904 )
2015
34
Dilemmas in diagnosis and natural history of renal oncocytoma and implications for management. ( 26664505 )
2015
35
Papillary renal cell carcinoma within a renal oncocytoma: Case report of very rare coexistence. ( 25553171 )
2014
36
Renal oncocytoma with invasive histopathologic features -a88 case report. ( 24739051 )
2014
37
An interesting case of F-18 fluorodeoxyglucose positron emission tomography avid renal oncocytoma. ( 24735168 )
2014
38
Renal oncocytoma: A diagnostic dilemma on cytology. ( 25190989 )
2014
39
C-kit overexpression is not associated with KIT gene mutations in chromophobe renal cell carcinoma or renal oncocytoma. ( 24875296 )
2014
40
Diagnostic accuracy of segmental enhancement inversion for the diagnosis of renal oncocytoma using biphasic computed tomography (CT) and multiphase contrast-enhanced magnetic resonance imaging (MRI). ( 25027841 )
2014
41
Diagnostic accuracy of segmental enhancement inversion for diagnosis of renal oncocytoma at biphasic contrast enhanced CT: systematic review. ( 24663821 )
2014
42
Ultrasonographic features of renal oncocytoma with histopathologic correlation. ( 24449166 )
2014
43
TGF-I^1 expression in chromophobe renal cell carcinoma and renal oncocytoma. ( 24704995 )
2014
44
Primary penile melanoma with an incidental renal oncocytoma. ( 24031073 )
2013
45
Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma. ( 23318578 )
2013
46
The Management Of A Concomitant Renal Oncocytoma, Giant Coronary And Bilateral Common Iliac Artery Aneurysms. ( 24200531 )
2013
47
Tumour-to-tumour metastases: prostate carcinoma metastasising to a renal oncocytoma. ( 23307454 )
2013
48
Renal oncocytoma: contrast-enhanced sonographic features. ( 23443184 )
2013
49
Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. ( 23617489 )
2013
50
Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. ( 23765540 )
2013

Variations for Renal Oncocytoma

Cosmic variations for Renal Oncocytoma:

9
(show top 50) (show all 249)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM25680 VHL kidney,NS,carcinoma,oncocytic c.563T>G p.L188R 3:10149886-10149886 7
2 COSM26012 UBR4 kidney,NS,carcinoma,oncocytic c.4564G>A p.A1522T 1:19164389-19164389 7
3 COSM25647 SMC6 kidney,NS,carcinoma,oncocytic c.2911-1G>C p.? 2:17670576-17670576 7
4 COSM130403 SF3B1 kidney,NS,carcinoma,oncocytic c.3122G>A p.R1041H 2:197398473-197398473 7
5 COSM28419 MDH1 kidney,NS,carcinoma,oncocytic c.894G>C p.K298N 2:63606876-63606876 7
6 COSM27600 FOXA2 kidney,NS,carcinoma,oncocytic c.72C>T p.G24G 20:22583152-22583152 7
7 COSM26015 ALDH7A1 kidney,NS,carcinoma,oncocytic c.1486A>G p.I496V 5:126545015-126545015 7
8 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma c.563G>C p.G188A 23:123886225-123886225 6
9 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma c.353T>C p.L118P 3:10146526-10146526 6
10 COSM14380 VHL kidney,NS,carcinoma,renal cell carcinoma c.548C>A p.S183* 3:10149871-10149871 6
11 COSM18350 VHL kidney,NS,carcinoma,renal cell carcinoma c.256C>T p.P86S 3:10142103-10142103 6
12 COSM17957 VHL kidney,NS,carcinoma,renal cell carcinoma c.292T>G p.Y98D 3:10142139-10142139 6
13 COSM14382 VHL kidney,NS,carcinoma,renal cell carcinoma c.245G>C p.R82P 3:10142092-10142092 6
14 COSM14305 VHL kidney,NS,carcinoma,renal cell carcinoma c.266T>A p.L89H 3:10142113-10142113 6
15 COSM25676 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 6
16 COSM17875 VHL kidney,NS,carcinoma,renal cell carcinoma c.234T>G p.N78K 3:10142081-10142081 6
17 COSM17983 VHL kidney,NS,carcinoma,renal cell carcinoma c.500G>A p.R167Q 3:10149823-10149823 6
18 COSM18097 VHL kidney,NS,carcinoma,renal cell carcinoma c.482G>A p.R161Q 3:10149805-10149805 6
19 COSM14425 VHL kidney,NS,carcinoma,renal cell carcinoma c.341-2A>T p.? 3:10146512-10146512 6
20 COSM17872 VHL kidney,NS,carcinoma,renal cell carcinoma c.217C>T p.Q73* 3:10142064-10142064 6
21 COSM27269 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176L 3:124737785-124737785 6
22 COSM6957851 TSC2 kidney,NS,carcinoma,renal cell carcinoma c.541G>A p.V181M 16:2055461-2055461 6
23 COSM6942356 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.2287C>T p.Q763* 9:132902709-132902709 6
24 COSM6963117 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.1001C>A p.S334* 9:132911481-132911481 6
25 COSM29770 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.508+1G>T p.? 9:132923347-132923347 6
26 COSM30474 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 5:14508136-14508136 6
27 COSM10656 TP53 kidney,NS,carcinoma,renal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 6
28 COSM45243 TP53 kidney,NS,carcinoma,renal cell carcinoma c.374C>G p.T125R 17:7675995-7675995 6
29 COSM10647 TP53 kidney,NS,carcinoma,renal cell carcinoma c.404G>T p.C135F 17:7675208-7675208 6
30 COSM44310 TP53 kidney,NS,carcinoma,renal cell carcinoma c.738G>A p.M246I 17:7674225-7674225 6
31 COSM6922197 TP53 kidney,NS,carcinoma,renal cell carcinoma c.97-2A>C p.? 17:7676274-7676274 6
32 COSM45135 TP53 kidney,NS,carcinoma,renal cell carcinoma c.673-1G>T p.? 17:7674291-7674291 6
33 COSM6929752 TBX3 kidney,NS,carcinoma,renal cell carcinoma c.510G>T p.W170C 12:114681026-114681026 6
34 COSM6979493 STAG2 kidney,NS,carcinoma,renal cell carcinoma c.2096+1G>A p.? 23:124065947-124065947 6
35 COSM6975582 STAG2 kidney,NS,carcinoma,renal cell carcinoma c.1348A>T p.R450* 23:124057909-124057909 6
36 COSM6023628 STAG2 kidney,NS,carcinoma,renal cell carcinoma c.2860C>T p.R954C 23:124081464-124081464 6
37 COSM6963119 SPOP kidney,NS,carcinoma,renal cell carcinoma c.265T>G p.L89V 17:49619321-49619321 6
38 COSM6964939 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma c.987-2A>T p.? 22:23833570-23833570 6
39 COSM989 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma c.1130G>A p.R377H 22:23834152-23834152 6
40 COSM1266238 SMARCA4 kidney,NS,carcinoma,renal cell carcinoma c.3575G>A p.R1192H 19:11033318-11033318 6
41 COSM6947611 SETD2 kidney,NS,carcinoma,renal cell carcinoma c.863C>A p.S288* 3:47122264-47122264 6
42 COSM6975580 SETD2 kidney,NS,carcinoma,renal cell carcinoma c.4736C>G p.S1579* 3:47062211-47062211 6
43 COSM4118007 SETD2 kidney,NS,carcinoma,renal cell carcinoma c.3266G>A p.R1089Q 3:47106061-47106061 6
44 COSM4794860 SETD2 kidney,NS,carcinoma,renal cell carcinoma c.5922+1G>A p.? 3:47019759-47019759 6
45 COSM26594 RNF144A kidney,NS,carcinoma,renal cell c.410C>T p.A137V 2:7020581-7020581 6
46 COSM26987 RGS7 kidney,NS,carcinoma,renal cell c.169T>C p.F57L 1:241098672-241098672 6
47 COSM6925125 RBM10 kidney,NS,carcinoma,renal cell carcinoma c.179C>A p.S60* 23:47169476-47169476 6
48 COSM6922201 RBM10 kidney,NS,carcinoma,renal cell carcinoma c.299G>C p.G100A 23:47171125-47171125 6
49 COSM26614 RABGAP1 kidney,NS,carcinoma,renal cell c.1533T>A p.H511Q 9:123020414-123020414 6
50 COSM30530 PTPN22 kidney,NS,carcinoma,renal cell c.209G>C p.R70P 1:113859066-113859066 6

Expression for Renal Oncocytoma

LifeMap Discovery
Genes differentially expressed in tissues of Renal Oncocytoma patients vs. healthy controls: 35 (show top 50) (show all 310)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ACSM2A acyl-CoA synthetase medium-chain family member 2A Kidney - 11.65 0.000
2 ALDOB aldolase B, fructose-bisphosphate Kidney - 9.16 0.000
3 NAT8 N-acetyltransferase 8 (GCN5-related, putative) Kidney - 9.12 0.000
4 GLYAT glycine-N-acyltransferase Kidney - 8.92 0.000
5 CTXN3 cortexin 3 Kidney - 8.72 0.000
6 ALDH8A1 aldehyde dehydrogenase 8 family, member A1 Kidney - 8.58 0.000
7 SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 Kidney - 8.51 0.000
8 HPD 4-hydroxyphenylpyruvate dioxygenase Kidney - 8.48 0.000
9 FABP1 fatty acid binding protein 1, liver Kidney - 8.41 0.000
10 GSTA1 glutathione S-transferase alpha 1 Kidney - 8.32 0.000
11 CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Kidney + 8.25 0.000
12 CXCL14 chemokine (C-X-C motif) ligand 14 Kidney - 8.13 0.000
13 PLG plasminogen Kidney - 8.11 0.000
14 MUC15 mucin 15, cell surface associated Kidney - 8.04 0.000
15 ACMSD aminocarboxymuconate semialdehyde decarboxylase Kidney - 7.88 0.000
16 CALB1 calbindin 1, 28kDa Kidney - 7.86 0.000
17 RNF128 ring finger protein 128, E3 ubiquitin protein ligase Kidney - 7.83 0.000
18 FMO1 flavin containing monooxygenase 1 Kidney - 7.79 0.000
19 UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 Kidney - 7.75 0.000
20 PAH phenylalanine hydroxylase Kidney - 7.75 0.000
21 KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 Kidney - 7.71 0.000
22 G6PC glucose-6-phosphatase, catalytic subunit Kidney - 7.61 0.000
23 SCNN1G sodium channel, non voltage gated 1 gamma subunit Kidney - 7.61 0.000
24 AGXT2 alanine--glyoxylate aminotransferase 2 Kidney - 7.60 0.000
25 AQP6 aquaporin 6, kidney specific Kidney + 7.57 0.000
26 SLC16A9 solute carrier family 16, member 9 Kidney - 7.57 0.000
27 ALB albumin Kidney - 7.54 0.000
28 PDZK1IP1 PDZK1 interacting protein 1 Kidney - 7.52 0.000
29 MFSD4 major facilitator superfamily domain containing 4 Kidney - 7.44 0.000
30 MIOX myo-inositol oxygenase Kidney - 7.39 0.000
31 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 Kidney - 7.33 0.000
32 SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 Kidney - 7.29 0.000
33 TMEM37 transmembrane protein 37 Kidney - 7.26 0.000
34 UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 Kidney - 7.21 0.000
35 LOC100505650 uncharacterized LOC100505650 Kidney - 7.19 0.000
36 ANPEP alanyl (membrane) aminopeptidase Kidney - 7.17 0.000
37 FAM151A family with sequence similarity 151, member A Kidney - 7.15 0.000
38 C1S complement component 1, s subcomponent Kidney - 7.01 0.000
39 CLRN3 clarin 3 Kidney - 6.96 0.000
40 EHF ets homologous factor Kidney - 6.86 0.000
41 SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Kidney - 6.86 0.000
42 MGAM maltase-glucoamylase Kidney - 6.85 0.000
43 TMEM255A transmembrane protein 255A Kidney + 6.84 0.000
44 TMEM45B transmembrane protein 45B Kidney - 6.80 0.000
45 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 Kidney - 6.78 0.000
46 BHMT betaine--homocysteine S-methyltransferase Kidney - 6.77 0.000
47 NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) Kidney - 6.77 0.000
48 IRX2 iroquois homeobox 2 Kidney - 6.75 0.000
49 GLYATL1 glycine-N-acyltransferase-like 1 Kidney - 6.73 0.000
50 MT1F metallothionein 1F Kidney - 6.70 0.000
Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for Renal Oncocytoma

Pathways related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 EPCAM KIT MME

GO Terms for Renal Oncocytoma

Cellular components related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 CAV1 CDH16 CLDN8 EPCAM FLCN KIT
2 basolateral plasma membrane GO:0016323 9.33 CDH16 CLDN8 EPCAM
3 integral component of plasma membrane GO:0005887 9.1 CAV1 CDH16 EPCAM KIT MME MST1R

Biological processes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 9.16 EPCAM KIT
2 cellular response to peptide hormone stimulus GO:0071375 8.96 CAV1 MAX
3 negative regulation of signal transduction GO:0009968 8.8 CAV1 KIT MST1R

Molecular functions related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 CAV1 CLDN8 KRT7
2 protein-containing complex binding GO:0044877 8.8 EPCAM FLCN MAX

Sources for Renal Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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