MCID: RNL017
MIFTS: 52

Renal Oncocytoma

Categories: Cancer diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Oncocytoma

MalaCards integrated aliases for Renal Oncocytoma:

Name: Renal Oncocytoma 12 53 15
Oncocytoma, Renal 44 72
Renal Epithelial Oncocytic Tumor 12
Oncocytoma of Kidney 12
Oncocytoma Kidney 53
Kidney Oncocytoma 17
Oncocytoma Renal 53

Classifications:



External Ids:

Disease Ontology 12 DOID:6245
MeSH 44 C537750
NCIt 50 C4526
UMLS 72 C0346255

Summaries for Renal Oncocytoma

NIH Rare Diseases : 53 Renal oncocytoma is a benign (noncancerous) growth of the kidney. They generally do not cause any signs or symptoms and are often discovered incidentally (by chance) while a person is undergoing diagnostic imaging for other conditions. Some people with renal oncocytoma will have abdominal or flank pain; blood in the urine; and/or an abdominal mass. Although these tumors can occur in people of all ages, they most commonly develop in men who are over age 50. The exact underlying cause of most isolated (single tumor affecting one kidney) renal oncocytomas is unknown; however, multiple and bilateral (affecting both kidneys) renal oncocytomas sometimes occur in people with certain genetic syndromes such as tuberous sclerosis complex and Birt-Hogg-Dube syndrome. Although many benign tumors do not require treatment unless they are causing unpleasant symptoms, it can be difficult to confidently differentiate a renal oncocytoma from renal cell carcinoma. Most affected people are, therefore, treated with surgery which allows for confirmation of the diagnosis.

MalaCards based summary : Renal Oncocytoma, also known as oncocytoma, renal, is related to oncocytoma and cystic nephroma. An important gene associated with Renal Oncocytoma is CLDN8 (Claudin 8), and among its related pathways/superpathways is Dendritic Cells Developmental Lineage Pathway. The drugs Radiopharmaceuticals and Technetium Tc 99m Sestamibi have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 75 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of... more...

Related Diseases for Renal Oncocytoma

Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 oncocytoma 30.8 MME KRT7 KIT FLCN CLDN8 CDH16
2 cystic nephroma 30.6 MME KIT
3 adenoid cystic carcinoma 29.9 KRT7 KIT CCND1
4 myeloma, multiple 29.9 MME KIT CCND1
5 chromophobe renal cell carcinoma 29.7 MME KRT7 KIT FLCN EPCAM CLDN8
6 renal cell carcinoma, papillary, 1 29.6 SDHB MME KRT7 KIT CDH16
7 clear cell renal cell carcinoma 29.4 MME KRT7 FLCN CDH16 CAV1
8 renal cell carcinoma, nonpapillary 29.1 SDHB MME KRT7 KIT FLCN EPCAM
9 familial renal oncocytoma 12.6
10 birt-hogg-dube syndrome 11.7
11 ceruminoma 10.6 KRT7 KIT
12 jejunal cancer 10.6 KRT7 KIT
13 intratubular embryonal carcinoma 10.6 KRT7 KIT
14 cribriform carcinoma 10.6 KRT7 KIT
15 adenoid basal cell carcinoma 10.6 KRT7 KIT
16 warthin tumor 10.5 KRT7 KIT
17 balloon cell malignant melanoma 10.5 MME KRT7
18 cervical adenoma malignum 10.5 MME KRT7
19 clear cell papillary renal cell carcinoma 10.5 MME KRT7
20 cervical mucinous adenocarcinoma 10.5 MME KRT7
21 adenomyoma 10.5 MME KRT7
22 bladder lymphoma 10.5 MME KRT7
23 benign breast phyllodes tumor 10.5 MME KIT
24 dermoid cyst 10.5 KRT7 KIT
25 adenoma 10.5
26 rete testis adenocarcinoma 10.5 MME KIT
27 jejunal adenocarcinoma 10.5 KRT7 CCND1
28 prostatic acinar adenocarcinoma 10.5 KRT7 KIT
29 mucinous tubular and spindle renal cell carcinoma 10.5 MME KRT7
30 breast myoepithelial neoplasm 10.5 MME KRT7
31 perivascular epithelioid cell tumor 10.5 MME KIT
32 breast adenomyoepithelioma 10.5 MME KRT7
33 papillary hidradenoma 10.5 MME KIT
34 cystadenofibroma 10.5 MME KRT7
35 necrotizing sialometaplasia 10.5 KRT7 KIT
36 infiltrative basal cell carcinoma 10.5 MME KRT7
37 adenosarcoma 10.4 MME KIT
38 eccrine sweat gland neoplasm 10.4 MME KRT7
39 rete testis neoplasm 10.4 MME KIT
40 collecting duct carcinoma 10.4 MME KRT7
41 malignant biphasic mesothelioma 10.4 KRT7 EPCAM
42 lymphoepithelioma-like thymic carcinoma 10.4 KIT EPCAM
43 pancreatic mucinous cystadenoma 10.4 MME KRT7
44 cystadenoma 10.4 MME KRT7
45 cll/sll 10.4 MME CCND1
46 large cell neuroendocrine carcinoma 10.4 KRT7 KIT
47 tonsil cancer 10.4 KRT7 KIT
48 chromophil renal cell carcinoma 10.4
49 smooth muscle tumor 10.4 MME KIT
50 cystic kidney disease 10.3

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to Renal Oncocytoma

Symptoms & Phenotypes for Renal Oncocytoma

MGI Mouse Phenotypes related to Renal Oncocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 CAV1 CCND1 CLDN8 EPCAM FLCN FOXI1
2 cardiovascular system MP:0005385 9.73 CAV1 CCND1 CLDN8 EPCAM FLCN KIT
3 neoplasm MP:0002006 9.35 CAV1 CCND1 FLCN KIT SDHB
4 renal/urinary system MP:0005367 9.17 CAV1 CLDN8 FLCN FOXI1 KIT KRT7

Drugs & Therapeutics for Renal Oncocytoma

Drugs for Renal Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Radiopharmaceuticals
2 Technetium Tc 99m Sestamibi

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Completed NCT02160925
2 Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders Recruiting NCT00001238
3 Study Evaluating the Interest of Cytology-molecular Tumor Markers Association for the Diagnostic Strategy in Adult Kidney Tumors Terminated NCT00491621

Search NIH Clinical Center for Renal Oncocytoma

Cochrane evidence based reviews: oncocytoma, renal

Genetic Tests for Renal Oncocytoma

Anatomical Context for Renal Oncocytoma

MalaCards organs/tissues related to Renal Oncocytoma:

41
Kidney, T Cells, Brain, Prostate, Liver, Breast, Thyroid

Publications for Renal Oncocytoma

Articles related to Renal Oncocytoma:

(show top 50) (show all 715)
# Title Authors PMID Year
1
Sporadic renal hybrid oncocytic/chromophobe tumor in a young man: A case report. 38
31415358 2019
2
[Retrospective study of diagnosis and treatment of renal oncocytoma]. 38
31420623 2019
3
Validation of Region of Interest Measurements for the Objective Assessment of Post-Contrast Enhancement of Renal Lesions on MRI. 38
31365281 2019
4
A Case of Renal Oncocytoma with Renal Venous Tumor Thrombus. 38
30473547 2019
5
Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. 38
31231128 2019
6
FOXI1 Immunohistochemistry Differentiates Benign Renal Oncocytoma from Malignant Chromophobe Renal Cell Carcinoma. 38
31177114 2019
7
Utility of cytokeratin 7, S100A1 and caveolin-1 as immunohistochemical biomarkers to differentiate chromophobe renal cell carcinoma from renal oncocytoma. 38
31236330 2019
8
The "central stellate scar" sign in renal oncocytoma. 38
30697659 2019
9
Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations. 38
31112346 2019
10
A promising biomarker to distinguish benign and malignant renal tumors: ELABELA. 38
30837428 2019
11
Case report of a combined oncocytoma and type 1 papillary renal cell carcinoma: a rare entity. 38
31217621 2019
12
Autoantibody against arrestin-1 as a potential biomarker of renal cell carcinoma. 38
30389514 2019
13
Renal Oncocytoma and Retroperitoneal Ancient Schwannoma: A Benign Mimic of Metastatic Renal Cell Carcinoma. 38
30915254 2019
14
Cystic renal oncocytoma mimicking renal cell carcinoma. 38
30787581 2019
15
Discrimination of oncocytoma and chromophobe renal cell carcinoma using MRI. 38
30644365 2019
16
A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1╬▒ in a Von Hippel-Lindau Renal Oncocytoma. 38
30728892 2019
17
Hybrid oncocytic/chromophobe renal cell tumor: An integrated genetic and epigenetic characterization of a case. 38
30343009 2018
18
Ureteral obstruction by sloughed tumor complicating cryoablation of a renal oncocytoma. 38
30533167 2018
19
Autoimmune retinopathy and optic neuropathy associated with enolase-positive renal oncocytoma. 38
30229140 2018
20
Caspase 3 as a Novel Marker to Distinguish Chromophobe Renal Cell Carcinoma from Oncocytoma. 38
30467700 2018
21
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? 38
29970253 2018
22
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. 38
29752278 2018
23
Papillary renal cell carcinoma with cytologic and molecular genetic features overlapping with renal oncocytoma: Analysis of 10 cases. 38
30072012 2018
24
Incidentally detected ectopic thyroid in juxta cardiac location-Imaging and pathology. 38
30008980 2018
25
Oncocytoma managed by active surveillance in a transplant allograft kidney: a case report. 38
29966524 2018
26
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. 38
29915083 2018
27
Contemporary surgical management of renal oncocytoma: a nation's outcome. 38
29397002 2018
28
A back-to-back tumor composed of papillary renal cell carcinoma and oncocytoma treated by laparoscopic partial nephrectomy: a case report. 38
29779490 2018
29
Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. 38
29353061 2018
30
BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors. 38
28470573 2018
31
MicroRNAs as Urinary Biomarker for Oncocytoma. 38
30116406 2018
32
A Rare Benign Tumor in a 14-Year-Old Girl. 38
29666728 2018
33
A miRNA-based classification of renal cell carcinoma subtypes by PCR and in situ hybridization. 38
29416756 2018
34
Extrarenal retroperitoneal angiomyolipoma with oncocytoma. 38
29343920 2018
35
Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report. 38
29796579 2018
36
Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione. 38
29285300 2017
37
Diffusion-weighted imaging versus contrast-enhanced MR imaging for the differentiation of renal oncocytomas and chromophobe renal cell carcinomas. 38
28631081 2017
38
Renal hybrid oncocytic/chromophobe tumor associated with multiple schwannomas: Case report and literature review. 38
29310387 2017
39
Renal Angiomyolipoma With Incidental Oncocytoma: A Case Report and Review of Literature. 38
29088523 2017
40
Value of triphasic MDCT in the differentiation of small renal cell carcinoma and oncocytoma. 38
28862728 2017
41
Characterizing Indeterminate Renal Masses with Molecular Imaging: the Role of 99mTc-MIBI SPECT/CT. 38
28900880 2017
42
Remote Development of Tumor-to-Tumor Metastasis of Breast Adenocarcinoma in a Renal Oncocytoma. 38
28551171 2017
43
Re: The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. 38
29370653 2017
44
Liver Metastases From Renal Oncocytoma With Vascular Extension. 38
28682831 2017
45
[Application of mini-flank open nephron sparing surgery via retroperitoneal route for centrally located renal tumor treatment: a single center experience]. 38
28763900 2017
46
Characteristics of the peritumoral pseudocapsule vary predictably with histologic subtype of T1 renal neoplasms. Jacob JM, Williamson SR, Gondim DD, Leese JA, Terry C, Grignon DJ, Boris RS.Urology. November 2015;86(5):956-961. 38
28416107 2017
47
Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists. 38
28315424 2017
48
Oncocytoma: A Differential Consideration for an Incidentally Detected FDG-Avid Renal Mass on PET/CT. 38
29299091 2017
49
Renal cell carcinoma: applicability of the apparent coefficient of the diffusion-weighted estimated by MRI for improving their differential diagnosis, histologic subtyping, and differentiation grade. 38
27853915 2017
50
Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. 38
27595574 2017

Variations for Renal Oncocytoma

Cosmic variations for Renal Oncocytoma:

9 (show top 50) (show all 267)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 15
2 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 3:10146526-10146526 15
3 COSM14380 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.548C>A p.S183* 3:10149871-10149871 15
4 COSM18350 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.256C>T p.P86S 3:10142103-10142103 15
5 COSM17957 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.292T>G p.Y98D 3:10142139-10142139 15
6 COSM14305 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 3:10142113-10142113 15
7 COSM14382 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 3:10142092-10142092 15
8 COSM25676 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 15
9 COSM17875 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.234T>G p.N78K 3:10142081-10142081 15
10 COSM17983 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.500G>A p.R167Q 3:10149823-10149823 15
11 COSM18097 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.482G>A p.R161Q 3:10149805-10149805 15
12 COSM14425 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-2A>T p.? 3:10146512-10146512 15
13 COSM25680 VHL kidney,NS,carcinoma,oncocytic c.563T>G p.L188R 3:10149886-10149886 15
14 COSM17872 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.217C>T p.Q73* 3:10142064-10142064 15
15 COSM27269 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176L 3:124737785-124737785 15
16 COSM26012 UBR4 kidney,NS,carcinoma,oncocytic c.4564G>A p.A1522T 1:19164389-19164389 15
17 COSM7349320 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1119+1G>T p.? 16:2060814-2060814 15
18 COSM7349613 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.976-1G>A p.? 16:2060669-2060669 15
19 COSM7349594 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2356-1G>C p.? 16:2074199-2074199 15
20 COSM7349602 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1636G>T p.E546* 16:2065555-2065555 15
21 COSM7349619 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.390C>G p.Y130* 16:2054349-2054349 15
22 COSM7349321 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1600-1G>T p.? 16:2065518-2065518 15
23 COSM7349621 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.774+1G>A p.? 16:2056770-2056770 15
24 COSM7349639 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.731G>T p.C244F 16:2056726-2056726 15
25 COSM7349636 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1189C>T p.Q397* 16:2061940-2061940 15
26 COSM6957851 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.541G>A p.V181M 16:2055461-2055461 15
27 COSM7349616 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1717-1G>C p.? 16:2070455-2070455 15
28 COSM1272079 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3412C>T p.R1138* 16:2080179-2080179 15
29 COSM6943738 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.975+1G>T p.? 16:2058874-2058874 15
30 COSM7349328 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1835T>A p.L612* 9:132905743-132905743 15
31 COSM7349331 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1276G>T p.D426Y 9:132907358-132907358 15
32 COSM6942356 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2287C>T p.Q763* 9:132902709-132902709 15
33 COSM6963117 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1001C>A p.S334* 9:132911481-132911481 15
34 COSM29770 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.508+1G>T p.? 9:132923347-132923347 15
35 COSM30474 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 5:14508136-14508136 15
36 COSM10656 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.742C>T p.R248W 17:7674221-7674221 15
37 COSM45243 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.374C>G p.T125R 17:7675995-7675995 15
38 COSM44310 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.738G>A p.M246I 17:7674225-7674225 15
39 COSM6922197 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.97-2A>C p.? 17:7676274-7676274 15
40 COSM45135 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.673-1G>T p.? 17:7674291-7674291 15
41 COSM10647 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.404G>T p.C135F 17:7675208-7675208 15
42 COSM6929752 TBX3 kidney,NS,carcinoma,renal cell carcinoma unclassified c.510G>T p.W170C 12:114681026-114681026 15
43 COSM6979493 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2096+1G>A p.? 23:124065947-124065947 15
44 COSM6975582 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1348A>T p.R450* 23:124057909-124057909 15
45 COSM6023628 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2860C>T p.R954C 23:124081464-124081464 15
46 COSM6963119 SPOP kidney,NS,carcinoma,renal cell carcinoma unclassified c.265T>G p.L89V 17:49619321-49619321 15
47 COSM25647 SMC6 kidney,NS,carcinoma,oncocytic c.2911-1G>C p.? 2:17670576-17670576 15
48 COSM6964939 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.987-2A>T p.? 22:23833570-23833570 15
49 COSM989 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1130G>A p.R377H 22:23834152-23834152 15
50 COSM1266238 SMARCA4 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3575G>A p.R1192H 19:11033318-11033318 15

Expression for Renal Oncocytoma

LifeMap Discovery
Genes differentially expressed in tissues of Renal Oncocytoma patients vs. healthy controls: 35 (show top 50) (show all 310)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ACSM2A acyl-CoA synthetase medium-chain family member 2A Kidney - 11.65 0.000
2 ALDOB aldolase B, fructose-bisphosphate Kidney - 9.16 0.000
3 NAT8 N-acetyltransferase 8 (GCN5-related, putative) Kidney - 9.12 0.000
4 GLYAT glycine-N-acyltransferase Kidney - 8.92 0.000
5 CTXN3 cortexin 3 Kidney - 8.72 0.000
6 ALDH8A1 aldehyde dehydrogenase 8 family, member A1 Kidney - 8.58 0.000
7 SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 Kidney - 8.51 0.000
8 HPD 4-hydroxyphenylpyruvate dioxygenase Kidney - 8.48 0.000
9 FABP1 fatty acid binding protein 1, liver Kidney - 8.41 0.000
10 GSTA1 glutathione S-transferase alpha 1 Kidney - 8.32 0.000
11 CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Kidney + 8.25 0.000
12 CXCL14 chemokine (C-X-C motif) ligand 14 Kidney - 8.13 0.000
13 PLG plasminogen Kidney - 8.11 0.000
14 MUC15 mucin 15, cell surface associated Kidney - 8.04 0.000
15 ACMSD aminocarboxymuconate semialdehyde decarboxylase Kidney - 7.88 0.000
16 CALB1 calbindin 1, 28kDa Kidney - 7.86 0.000
17 RNF128 ring finger protein 128, E3 ubiquitin protein ligase Kidney - 7.83 0.000
18 FMO1 flavin containing monooxygenase 1 Kidney - 7.79 0.000
19 UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 Kidney - 7.75 0.000
20 PAH phenylalanine hydroxylase Kidney - 7.75 0.000
21 KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 Kidney - 7.71 0.000
22 G6PC glucose-6-phosphatase, catalytic subunit Kidney - 7.61 0.000
23 SCNN1G sodium channel, non voltage gated 1 gamma subunit Kidney - 7.61 0.000
24 AGXT2 alanine--glyoxylate aminotransferase 2 Kidney - 7.60 0.000
25 AQP6 aquaporin 6, kidney specific Kidney + 7.57 0.000
26 SLC16A9 solute carrier family 16, member 9 Kidney - 7.57 0.000
27 ALB albumin Kidney - 7.54 0.000
28 PDZK1IP1 PDZK1 interacting protein 1 Kidney - 7.52 0.000
29 MFSD4 major facilitator superfamily domain containing 4 Kidney - 7.44 0.000
30 MIOX myo-inositol oxygenase Kidney - 7.39 0.000
31 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 Kidney - 7.33 0.000
32 SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 Kidney - 7.29 0.000
33 TMEM37 transmembrane protein 37 Kidney - 7.26 0.000
34 UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 Kidney - 7.21 0.000
35 LOC100505650 uncharacterized LOC100505650 Kidney - 7.19 0.000
36 ANPEP alanyl (membrane) aminopeptidase Kidney - 7.17 0.000
37 FAM151A family with sequence similarity 151, member A Kidney - 7.15 0.000
38 C1S complement component 1, s subcomponent Kidney - 7.01 0.000
39 CLRN3 clarin 3 Kidney - 6.96 0.000
40 EHF ets homologous factor Kidney - 6.86 0.000
41 SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Kidney - 6.86 0.000
42 MGAM maltase-glucoamylase Kidney - 6.85 0.000
43 TMEM255A transmembrane protein 255A Kidney + 6.84 0.000
44 TMEM45B transmembrane protein 45B Kidney - 6.80 0.000
45 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 Kidney - 6.78 0.000
46 BHMT betaine--homocysteine S-methyltransferase Kidney - 6.77 0.000
47 NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) Kidney - 6.77 0.000
48 IRX2 iroquois homeobox 2 Kidney - 6.75 0.000
49 GLYATL1 glycine-N-acyltransferase-like 1 Kidney - 6.73 0.000
50 MT1F metallothionein 1F Kidney - 6.70 0.000
Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for Renal Oncocytoma

Pathways related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 MME KIT EPCAM

GO Terms for Renal Oncocytoma

Cellular components related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 SDHB MST1R MME KIT FLCN EPCAM
2 basolateral plasma membrane GO:0016323 9.33 EPCAM CLDN8 CDH16
3 bicellular tight junction GO:0005923 8.8 EPCAM CLDN8 CCND1

Biological processes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 MST1R KIT EPCAM CCND1
2 stem cell differentiation GO:0048863 9.16 KIT EPCAM
3 negative regulation of signal transduction GO:0009968 8.65 CAV1
4 negative regulation of epithelial cell differentiation GO:0030857 8.62 CCND1 CAV1

Molecular functions related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 CLDN8 CAV1

Sources for Renal Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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