MCID: RNL017
MIFTS: 53

Renal Oncocytoma

Categories: Cancer diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Oncocytoma

MalaCards integrated aliases for Renal Oncocytoma:

Name: Renal Oncocytoma 12 52 15
Oncocytoma, Renal 43 71
Renal Epithelial Oncocytic Tumor 12
Oncocytoma of Kidney 12
Oncocytoma Kidney 52
Kidney Oncocytoma 17
Oncocytoma Renal 52

Classifications:



External Ids:

Disease Ontology 12 DOID:6245
MeSH 43 C537750
NCIt 49 C4526
SNOMED-CT 67 254922006
UMLS 71 C0346255

Summaries for Renal Oncocytoma

NIH Rare Diseases : 52 Renal oncocytoma is a benign (noncancerous) growth of the kidney. They generally do not cause any signs or symptoms and are often discovered incidentally (by chance) while a person is undergoing diagnostic imaging for other conditions. Some people with renal oncocytoma will have abdominal or flank pain; blood in the urine; and/or an abdominal mass . Although these tumors can occur in people of all ages, they most commonly develop in men who are over age 50. The exact underlying cause of most isolated (single tumor affecting one kidney) renal oncocytomas is unknown; however, multiple and bilateral (affecting both kidneys) renal oncocytomas sometimes occur in people with certain genetic syndromes such as tuberous sclerosis complex and Birt-Hogg-Dube syndrome . Although many benign tumors do not require treatment unless they are causing unpleasant symptoms, it can be difficult to confidently differentiate a renal oncocytoma from renal cell carcinoma . Most affected people are, therefore, treated with surgery which allows for confirmation of the diagnosis.

MalaCards based summary : Renal Oncocytoma, also known as oncocytoma, renal, is related to eosinophilic variant of chromophobe renal cell carcinoma and renal adenoma. An important gene associated with Renal Oncocytoma is FLCN (Folliculin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. The drugs Technetium Tc 99m Sestamibi and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of... more...

Related Diseases for Renal Oncocytoma

Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 eosinophilic variant of chromophobe renal cell carcinoma 31.0 S100A1 CDH16
2 renal adenoma 30.9 MME KRT7 FLCN
3 angiomyolipoma 30.7 VIM S100A1 MME KRT7 KIT
4 leiomyoma 30.4 VIM S100A1 MME KIT
5 neurilemmoma 30.4 VIM S100A1 KIT
6 oncocytoma 30.3 VIM SDHB S100A1 PVALB MME KRT7
7 adenocarcinoma 30.3 MST1R KRT7 KIT EPCAM CCND1
8 pheochromocytoma 30.3 SDHB MME KRT7 KIT CCND1
9 leiomyosarcoma 30.2 VIM S100A1 KIT CCND1
10 renal cell carcinoma, papillary, 1 29.7 SDHB S100A1 MST1R MME KRT7 KIT
11 clear cell renal cell carcinoma 29.4 VIM SDHB MME KRT7 FLCN CLDN7
12 renal cell carcinoma, nonpapillary 29.0 VIM SDHB S100A1 PVALB MST1R MME
13 adenoid cystic carcinoma 28.9 VIM S100A1 KRT7 KRT14 KIT EPCAM
14 chromophobe renal cell carcinoma 28.7 VIM S100A1 PVALB MME KRT7 KIT
15 familial renal oncocytoma 12.6
16 birt-hogg-dube syndrome 11.7
17 anus basaloid carcinoma 10.6 KRT7 KIT
18 cervical adenoid cystic carcinoma 10.6 KRT7 KIT
19 nodular hidradenoma 10.6 VIM KRT7
20 testicular gonadoblastoma 10.6 VIM KIT
21 benign metastasizing leiomyoma 10.6 VIM KRT7
22 epithelial predominant wilms' tumor 10.6 KRT7 CDH16
23 papillary tumor of the pineal region 10.6 VIM S100A1
24 nephrogenic adenoma of urinary bladder 10.6 MME KRT7
25 wolffian duct adenoma 10.6 MME KRT7
26 lung adenoid cystic carcinoma 10.6 KRT7 KIT
27 jejunal neoplasm 10.6 KRT7 KIT
28 urethra leiomyoma 10.6 MME KIT
29 subareolar duct papillomatosis 10.6 MME KRT7
30 nipple benign neoplasm 10.6 MME KRT7
31 intratubular embryonal carcinoma 10.5 KRT7 KIT
32 adenoid basal cell carcinoma 10.5 KRT7 KIT
33 liver fibroma 10.5 VIM KIT
34 pancreatic serous cystadenocarcinoma 10.5 MME KRT7
35 mixed epithelial stromal tumour 10.5 MME KRT7
36 senile angioma 10.5 VIM KIT
37 multilocular clear cell renal cell carcinoma 10.5 FLCN CDH16
38 heart lymphoma 10.5 VIM MME
39 female urethral cancer 10.5 MME KRT7
40 mucocele of appendix 10.5 MME KIT
41 epididymal neoplasm 10.5 MME KRT7
42 clear cell papillary renal cell carcinoma 10.5 MME KRT7
43 adult cystic nephroma 10.5 MME KIT
44 pancreatic foamy gland adenocarcinoma 10.5 KRT7 CCND1
45 chromophil adenoma of the kidney 10.5 MME KRT7
46 uterus perivascular epithelioid cell tumor 10.5 MME KRT7
47 warthin tumor 10.5 KRT7 KIT
48 clear cell hidradenoma 10.5 MME KRT7
49 mast-cell sarcoma 10.5 VIM KIT
50 wolffian duct adenocarcinoma 10.5 MME KRT7

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to Renal Oncocytoma

Symptoms & Phenotypes for Renal Oncocytoma

GenomeRNAi Phenotypes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-3 10.25 MST1R
2 Decreased viability GR00221-A-1 10.25 KIT MST1R
3 Decreased viability GR00221-A-2 10.25 MST1R
4 Decreased viability GR00240-S-1 10.25 PVALB SDHB
5 Decreased viability GR00249-S 10.25 CCND1 CDH16 FOXI1 RNF115 S100A1 VIM
6 Decreased viability GR00301-A 10.25 KIT MST1R
7 Decreased viability GR00381-A-1 10.25 CDH16 PVALB
8 Decreased viability GR00386-A-1 10.25 ANKRD2 CAV1 CDH16 FOXI1 S100A1
9 Decreased viability GR00402-S-2 10.25 CCND1 MST1R RNF115 VIM
10 Reduced mammosphere formation GR00396-S 9.17 CAV1 CCND1 CD82 CLDN7 KRT7 MST1R
11 Increased the percentage of infected cells GR00402-S-1 8.65 FOXI1

MGI Mouse Phenotypes related to Renal Oncocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CAV1 CCND1 CD82 CLDN7 CLDN8 EPCAM
2 cardiovascular system MP:0005385 10.18 ANKRD2 CAV1 CCND1 CD82 CLDN8 EPCAM
3 cellular MP:0005384 10.18 CAV1 CCND1 CD82 EPCAM FLCN FOXI1
4 hematopoietic system MP:0005397 10.06 CAV1 CCND1 CLDN7 EPCAM FLCN KIT
5 mortality/aging MP:0010768 9.97 ANKRD2 CAV1 CCND1 CLDN7 EPCAM FLCN
6 neoplasm MP:0002006 9.5 CAV1 CCND1 CD82 FLCN KIT KRT14
7 renal/urinary system MP:0005367 9.28 CAV1 CLDN7 CLDN8 FLCN FOXI1 KIT

Drugs & Therapeutics for Renal Oncocytoma

Drugs for Renal Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Technetium Tc 99m Sestamibi
2 Radiopharmaceuticals

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Completed NCT02160925
2 Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders Recruiting NCT00001238
3 Study Evaluating the Interest of Cytology-molecular Tumor Markers Association for the Diagnostic Strategy in Adult Kidney Tumors Terminated NCT00491621

Search NIH Clinical Center for Renal Oncocytoma

Cochrane evidence based reviews: oncocytoma, renal

Genetic Tests for Renal Oncocytoma

Anatomical Context for Renal Oncocytoma

MalaCards organs/tissues related to Renal Oncocytoma:

40
Kidney, T Cells, Brain, Prostate, Liver, Thyroid, Breast

Publications for Renal Oncocytoma

Articles related to Renal Oncocytoma:

(show top 50) (show all 738)
# Title Authors PMID Year
1
Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous: Clinicopathologic and Molecular Study. 61
32091432 2020
2
Osteopontin is differentially expressed in renal cell tumors. 61
31914887 2020
3
Renal Oncocytoma: an algorithm for diagnosis and management. 61
32512107 2020
4
A non-diploid DNA status is linked to poor prognosis in renal cell cancer. 61
32361874 2020
5
The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma. 61
31640438 2020
6
[Evolution of followed renal oncocytomas]. 61
32376210 2020
7
Searching for prognostic biomarkers for small renal masses in the urinary proteome. 61
31465112 2020
8
Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors. 61
32365590 2020
9
Automated differentiation of benign renal oncocytoma and chromophobe renal cell carcinoma on computed tomography using deep learning. 61
31901213 2020
10
Single-center study: the diagnostic performance of contrast-enhanced ultrasound (CEUS) for assessing renal oncocytoma. 61
32162575 2020
11
The first report of renal oncocytoma in a patient with situs inversus totalis. 61
31948815 2020
12
Small-cell variant renal oncocytoma: Case report on its clinicopathological and genetic characteristics and literature review. 61
31809837 2020
13
Diagnostic accuracy of 99mTc-sestamibi SPECT/CT for detecting renal oncocytomas and other benign renal lesions: a systematic review and meta-analysis. 61
32193593 2020
14
Mass Spectrometry Imaging Enables Discrimination of Renal Oncocytoma from Renal Cell Cancer Subtypes and Normal Kidney Tissues. 61
31843980 2020
15
Prognostic urinary miRNAs for the assessment of small renal masses. 61
31672647 2020
16
Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis. 61
31998788 2020
17
Ultrasonic-assisted extraction and digestion of proteins from solid biopsies followed by peptide sequential extraction hyphenated to MALDI-based profiling holds the promise of distinguishing renal oncocytoma from chromophobe renal cell carcinoma. 61
31514886 2020
18
Identification of Prognostic Biomarkers in the Urinary Peptidome of the Small Renal Mass. 61
31761032 2019
19
Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. 61
31231128 2019
20
Validation of Region of Interest Measurements for the Objective Assessment of Post-Contrast Enhancement of Renal Lesions on MRI. 61
31365281 2019
21
Caspase 3 as a Novel Marker to Distinguish Chromophobe Renal Cell Carcinoma from Oncocytoma. 61
30467700 2019
22
Value of radiomics in differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. 61
31664486 2019
23
Sporadic renal hybrid oncocytic/chromophobe tumor in a young man: A case report. 61
31415358 2019
24
[Retrospective study of diagnosis and treatment of renal oncocytoma]. 61
31420623 2019
25
A Case of Renal Oncocytoma with Renal Venous Tumor Thrombus. 61
30473547 2019
26
FOXI1 Immunohistochemistry Differentiates Benign Renal Oncocytoma from Malignant Chromophobe Renal Cell Carcinoma. 61
31177114 2019
27
Utility of cytokeratin 7, S100A1 and caveolin-1 as immunohistochemical biomarkers to differentiate chromophobe renal cell carcinoma from renal oncocytoma. 61
31236330 2019
28
The "central stellate scar" sign in renal oncocytoma. 61
30697659 2019
29
Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations. 61
31112346 2019
30
A promising biomarker to distinguish benign and malignant renal tumors: ELABELA. 61
30837428 2019
31
Case report of a combined oncocytoma and type 1 papillary renal cell carcinoma: a rare entity. 61
31217621 2019
32
Autoantibody against arrestin-1 as a potential biomarker of renal cell carcinoma. 61
30389514 2019
33
Unusual Suspect: A Case Report of Tubulocystic Renal Cell Carcinoma with Features of Cystic Renal Oncocytoma. 61
31467765 2019
34
Renal Oncocytoma and Retroperitoneal Ancient Schwannoma: A Benign Mimic of Metastatic Renal Cell Carcinoma. 61
30915254 2019
35
Cystic renal oncocytoma mimicking renal cell carcinoma. 61
30787581 2019
36
Discrimination of oncocytoma and chromophobe renal cell carcinoma using MRI. 61
30644365 2019
37
Combined Immunohistochemistry for the "Three 7" Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution. 61
31737127 2019
38
Palpable Abdominal Mass is a Renal Oncocytoma: Not All Large Renal Masses are Malignant. 61
31485367 2019
39
Renal oncocytoma with vascular and perinephric fat invasion. 61
31700546 2019
40
A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1╬▒ in a Von Hippel-Lindau Renal Oncocytoma. 61
30728892 2019
41
Ureteral obstruction by sloughed tumor complicating cryoablation of a renal oncocytoma. 61
30533167 2018
42
Autoimmune retinopathy and optic neuropathy associated with enolase-positive renal oncocytoma. 61
30229140 2018
43
Hybrid oncocytic/chromophobe renal cell tumor: An integrated genetic and epigenetic characterization of a case. 61
30343009 2018
44
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. 61
29752278 2018
45
Papillary renal cell carcinoma with cytologic and molecular genetic features overlapping with renal oncocytoma: Analysis of 10 cases. 61
30072012 2018
46
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? 61
29970253 2018
47
Incidentally detected ectopic thyroid in juxta cardiac location-Imaging and pathology. 61
30008980 2018
48
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. 61
29915083 2018
49
Oncocytoma managed by active surveillance in a transplant allograft kidney: a case report. 61
29966524 2018
50
Contemporary surgical management of renal oncocytoma: a nation's outcome. 61
29397002 2018

Variations for Renal Oncocytoma

Cosmic variations for Renal Oncocytoma:

9 (show top 50) (show all 874)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM94289415 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 15
2 COSM88289113 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-2A>T p.? 3:10146512-10146512 15
3 COSM88297043 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 15
4 COSM88292918 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.500G>A p.R167Q 3:10149823-10149823 15
5 COSM88288959 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.482G>A p.R161Q 3:10149805-10149805 15
6 COSM88292107 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.256C>T p.P86S 3:10142103-10142103 15
7 COSM88293667 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.548C>A p.S183* 3:10149871-10149871 15
8 COSM88289297 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 3:10142113-10142113 15
9 COSM88290436 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 3:10146526-10146526 15
10 COSM88292022 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 3:10142092-10142092 15
11 COSM88289282 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.217C>T p.Q73* 3:10142064-10142064 15
12 COSM88291948 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.234T>G p.N78K 3:10142081-10142081 15
13 COSM88293959 VHL kidney,NS,carcinoma,oncocytic c.563T>G p.L188R 3:10149886-10149886 15
14 COSM88304413 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.292T>G p.Y98D 3:10142139-10142139 15
15 COSM85360217 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176= 3:124737785-124737785 15
16 COSM98482493 UBR4 kidney,NS,carcinoma,oncocytic c.4564G>A p.A1522T 1:19164389-19164389 15
17 COSM87037342 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2356-1G>C p.? 16:2074199-2074199 15
18 COSM87037337 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1636G>T p.E546* 16:2065555-2065555 15
19 COSM87037202 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.976-1G>A p.? 16:2060669-2060669 15
20 COSM87030528 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3412C>T p.R1138* 16:2080179-2080179 15
21 COSM87037219 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1717-1G>C p.? 16:2070455-2070455 15
22 COSM87037265 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.774+1G>A p.? 16:2056770-2056770 15
23 COSM87049432 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.541G>A p.V181M 16:2055461-2055461 15
24 COSM87037238 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.390C>G p.Y130* 16:2054349-2054349 15
25 COSM87037320 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.731G>T p.C244F 16:2056726-2056726 15
26 COSM87036869 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1119+1G>T p.? 16:2060814-2060814 15
27 COSM87037346 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.975+1G>T p.? 16:2058874-2058874 15
28 COSM87037324 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1189C>T p.Q397* 16:2061940-2061940 15
29 COSM87036879 TSC2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1600-1G>T p.? 16:2065518-2065518 15
30 COSM85719503 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2287C>T p.Q763* 9:132902709-132902709 15
31 COSM85723777 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1276G>T p.D426Y 9:132907358-132907358 15
32 COSM85727708 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1001C>A p.S334* 9:132911481-132911481 15
33 COSM85723822 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.508+1G>T p.? 9:132923347-132923347 15
34 COSM85723770 TSC1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1835T>A p.L612* 9:132905743-132905743 15
35 COSM89062698 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 5:14508136-14508136 15
36 COSM87921270 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.673-1G>T p.? 17:7674291-7674291 15
37 COSM88453050 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.97-2A>C p.? 17:7676274-7676274 15
38 COSM87908091 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.404G>T p.C135F 17:7675208-7675208 15
39 COSM87935614 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.738G>A p.M246I 17:7674225-7674225 15
40 COSM87898709 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.742C>T p.R248W 17:7674221-7674221 15
41 COSM87912624 TP53 kidney,NS,carcinoma,renal cell carcinoma unclassified c.374C>G p.T125R 17:7675995-7675995 15
42 COSM84063376 TBX3 kidney,NS,carcinoma,renal cell carcinoma unclassified c.510G>T p.W170C 12:114681026-114681026 15
43 COSM86748896 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2096+1G>A p.? 23:124065947-124065947 15
44 COSM86759462 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.2860C>T p.R954C 23:124081464-124081464 15
45 COSM86766292 STAG2 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1348A>T p.R450* 23:124057909-124057909 15
46 COSM100989027 SPOP kidney,NS,carcinoma,renal cell carcinoma unclassified c.265T>G p.L89V 17:49619321-49619321 15
47 COSM113655614 SMC6 kidney,NS,carcinoma,oncocytic c.2911-1G>C p.? 2:17670576-17670576 15
48 COSM90109955 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1014-2A>T p.? 22:23833570-23833570 15
49 COSM90104263 SMARCB1 kidney,NS,carcinoma,renal cell carcinoma unclassified c.1157G>A p.R386H 22:23834152-23834152 15
50 COSM89651052 SMARCA4 kidney,NS,carcinoma,renal cell carcinoma unclassified c.3575G>A p.R1192H 19:11033318-11033318 15

Expression for Renal Oncocytoma

LifeMap Discovery
Genes differentially expressed in tissues of Renal Oncocytoma patients vs. healthy controls: 35 (show top 50) (show all 310)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ACSM2A acyl-CoA synthetase medium-chain family member 2A Kidney - 11.65 0.000
2 ALDOB aldolase B, fructose-bisphosphate Kidney - 9.16 0.000
3 NAT8 N-acetyltransferase 8 (GCN5-related, putative) Kidney - 9.12 0.000
4 GLYAT glycine-N-acyltransferase Kidney - 8.92 0.000
5 CTXN3 cortexin 3 Kidney - 8.72 0.000
6 ALDH8A1 aldehyde dehydrogenase 8 family, member A1 Kidney - 8.58 0.000
7 SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 Kidney - 8.51 0.000
8 HPD 4-hydroxyphenylpyruvate dioxygenase Kidney - 8.48 0.000
9 FABP1 fatty acid binding protein 1, liver Kidney - 8.41 0.000
10 GSTA1 glutathione S-transferase alpha 1 Kidney - 8.32 0.000
11 CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Kidney + 8.25 0.000
12 CXCL14 chemokine (C-X-C motif) ligand 14 Kidney - 8.13 0.000
13 PLG plasminogen Kidney - 8.11 0.000
14 MUC15 mucin 15, cell surface associated Kidney - 8.04 0.000
15 ACMSD aminocarboxymuconate semialdehyde decarboxylase Kidney - 7.88 0.000
16 CALB1 calbindin 1, 28kDa Kidney - 7.86 0.000
17 RNF128 ring finger protein 128, E3 ubiquitin protein ligase Kidney - 7.83 0.000
18 FMO1 flavin containing monooxygenase 1 Kidney - 7.79 0.000
19 UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 Kidney - 7.75 0.000
20 PAH phenylalanine hydroxylase Kidney - 7.75 0.000
21 KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 Kidney - 7.71 0.000
22 G6PC glucose-6-phosphatase, catalytic subunit Kidney - 7.61 0.000
23 SCNN1G sodium channel, non voltage gated 1 gamma subunit Kidney - 7.61 0.000
24 AGXT2 alanine--glyoxylate aminotransferase 2 Kidney - 7.60 0.000
25 AQP6 aquaporin 6, kidney specific Kidney + 7.57 0.000
26 SLC16A9 solute carrier family 16, member 9 Kidney - 7.57 0.000
27 ALB albumin Kidney - 7.54 0.000
28 PDZK1IP1 PDZK1 interacting protein 1 Kidney - 7.52 0.000
29 MFSD4 major facilitator superfamily domain containing 4 Kidney - 7.44 0.000
30 MIOX myo-inositol oxygenase Kidney - 7.39 0.000
31 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 Kidney - 7.33 0.000
32 SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 Kidney - 7.29 0.000
33 TMEM37 transmembrane protein 37 Kidney - 7.26 0.000
34 UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 Kidney - 7.21 0.000
35 LOC100505650 uncharacterized LOC100505650 Kidney - 7.19 0.000
36 ANPEP alanyl (membrane) aminopeptidase Kidney - 7.17 0.000
37 FAM151A family with sequence similarity 151, member A Kidney - 7.15 0.000
38 C1S complement component 1, s subcomponent Kidney - 7.01 0.000
39 CLRN3 clarin 3 Kidney - 6.96 0.000
40 EHF ets homologous factor Kidney - 6.86 0.000
41 SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Kidney - 6.86 0.000
42 MGAM maltase-glucoamylase Kidney - 6.85 0.000
43 TMEM255A transmembrane protein 255A Kidney + 6.84 0.000
44 TMEM45B transmembrane protein 45B Kidney - 6.80 0.000
45 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 Kidney - 6.78 0.000
46 BHMT betaine--homocysteine S-methyltransferase Kidney - 6.77 0.000
47 NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) Kidney - 6.77 0.000
48 IRX2 iroquois homeobox 2 Kidney - 6.75 0.000
49 GLYATL1 glycine-N-acyltransferase-like 1 Kidney - 6.73 0.000
50 MT1F metallothionein 1F Kidney - 6.70 0.000
Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for Renal Oncocytoma

Pathways related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 VIM KRT7 EPCAM CAV1
2
Show member pathways
11.81 CLDN8 CLDN7 CCND1 CAV1
3
Show member pathways
11.37 VIM KRT7 KRT14
4 10.67 MME KIT EPCAM

GO Terms for Renal Oncocytoma

Cellular components related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.26 EPCAM CLDN8 CLDN7 CDH16
2 bicellular tight junction GO:0005923 8.92 EPCAM CLDN8 CLDN7 CCND1

Biological processes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.35 MST1R KIT EPCAM CLDN7 CCND1
2 negative regulation of epithelial cell differentiation GO:0030857 8.62 CCND1 CAV1

Molecular functions related to Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.35 PVALB FLCN EPCAM CCND1 CAV1
2 keratin filament binding GO:1990254 8.62 VIM KRT14

Sources for Renal Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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