MCID: RNL011
MIFTS: 49

Renal Osteodystrophy

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Renal Osteodystrophy

MalaCards integrated aliases for Renal Osteodystrophy:

Name: Renal Osteodystrophy 12 76 55 15 73
Renal Rickets 12 76 53 73
Chronic Kidney Disease-Mineral and Bone Disorder 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13068
ICD10 33 N25.0
ICD9CM 35 588.0
MeSH 44 D012080
NCIt 50 C114827

Summaries for Renal Osteodystrophy

MalaCards based summary : Renal Osteodystrophy, also known as renal rickets, is related to osteitis fibrosa and pseudohypoparathyroidism. An important gene associated with Renal Osteodystrophy is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Parathyroid hormone synthesis, secretion and action. The drugs Sevelamer and Pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Wikipedia : 76 Renal osteodystrophy is currently defined as an alteration of bone morphology in patients with chronic... more...

Related Diseases for Renal Osteodystrophy

Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 osteitis fibrosa 31.5 BGLAP CALCA CASR PTH
2 pseudohypoparathyroidism 30.1 BGLAP PTH
3 osteonecrosis 30.0 BGLAP PTH TNFRSF11B
4 uremia 29.6 CASR PTH TNFRSF11B VDR
5 hyperostosis 29.4 FGF23 SOST TNFRSF11B
6 rickets 29.4 BGLAP FGF23 PTH VDR
7 kidney disease 29.1 CASR FGF23 PTH TNFRSF11B VDR
8 osteomalacia 28.9 BGLAP CALCA CASR FGF23 VDR
9 hyperparathyroidism 28.0 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
10 primary hyperparathyroidism 27.8 BGLAP CALCA CASR FGF23 PTH VDR
11 secondary hyperparathyroidism of renal origin 27.7 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
12 chronic kidney failure 27.7 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
13 bone disease 26.5 BGLAP CALCA CASR FGF23 PTH SOST
14 osteoporosis 23.5 BGLAP CALCA CASR FGF23 IGFBP4 IGFBP5
15 abderhalden kaufmann lignac syndrome 10.9
16 axial osteomalacia 10.6 BGLAP PTH
17 extraskeletal chondroma 10.6 BGLAP PTH
18 hypercalciuria, absorptive, 2 10.6 CASR VDR
19 hypocalciuric hypercalcemia, familial, type iii 10.6 CASR PTH
20 hypoparathyroidism, familial isolated 10.6 CASR PTH
21 hypocalciuric hypercalcemia, familial, type ii 10.5 CASR PTH
22 familial hypocalciuric hypercalcemia 10.5 CASR PTH
23 pseudohypoparathyroidism, type ib 10.5 BGLAP PTH
24 xanthinuria, type i 10.5 CASR VDR
25 spondylosis 10.5 PTH VDR
26 oncogenic osteomalacia 10.5 FGF23 PTH
27 nephrolithiasis, calcium oxalate 10.4 CASR VDR
28 pulmonary alveolar microlithiasis 10.4 FGF23 PTH
29 hypophosphatemic rickets, x-linked recessive 10.4 FGF23 VDR
30 osteoporosis, juvenile 10.4 BGLAP CALCA
31 nontoxic goiter 10.4 BGLAP CALCA
32 peritonitis 10.3
33 chondrocalcinosis 10.3 CASR TNFRSF11B
34 idiopathic hypercalciuria 10.3 BGLAP CASR VDR
35 van buchem disease 10.3 SOST VDR
36 mccune-albright syndrome 10.3 BGLAP FGF23
37 kummell's disease 10.3 SOST TNFRSF11B
38 paget disease of bone 5, juvenile-onset 10.2 CALCA TNFRSF11B
39 hypophosphatemic rickets with hypercalciuria, hereditary 10.2 FGF23 PTH
40 cloacogenic carcinoma 10.2 CALCA PTH
41 sclerosteosis 10.2 SOST VDR
42 ankylosis 10.2 BGLAP TNFRSF11B
43 hypophosphatemia 10.2 BGLAP FGF23 PTH
44 multiple endocrine neoplasia, type iia 10.1 CALCA PTH
45 craniodiaphyseal dysplasia 10.1 CALCA SOST
46 hypervitaminosis d 10.1 FGF23 PTH VDR
47 hypophosphatemic rickets, x-linked dominant 10.1 FGF23 PTH VDR
48 ischemic bone disease 10.1 BGLAP PTH TNFRSF11B
49 root resorption 10.1 CALCA TNFRSF11B
50 hypocalcemia, autosomal dominant 1 10.1 CALCA CASR VDR

Comorbidity relations with Renal Osteodystrophy via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to Renal Osteodystrophy

Symptoms & Phenotypes for Renal Osteodystrophy

MGI Mouse Phenotypes related to Renal Osteodystrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 VDR CASR FGF23 IGFBP4 IGFBP5 PTH
2 endocrine/exocrine gland MP:0005379 9.73 VDR CASR FGF23 IGFBP4 IGFBP5 PTH
3 limbs/digits/tail MP:0005371 9.35 VDR FGF23 PTH SOST TNFRSF11B
4 skeleton MP:0005390 9.1 TNFRSF11B VDR CASR FGF23 PTH SOST

Drugs & Therapeutics for Renal Osteodystrophy

Drugs for Renal Osteodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevelamer Approved Phase 4,Phase 3,Phase 2 52757-95-6
2
Pamidronate Approved Phase 4 40391-99-9 4674
3
Zoledronic acid Approved Phase 4 118072-93-8 68740
4
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-14-6 5280793
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
6
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 6221 5280795
7 1 alpha-hydroxyergocalciferol Phase 4,Phase 2,Not Applicable
8 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Ergocalciferols Phase 4,Phase 3,Phase 2,Not Applicable
10 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Diphosphonates Phase 4
14 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
15 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable
16 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable
17
Calcium Carbonate Approved, Investigational Phase 3,Phase 2 471-34-1
18
Calcium acetate Approved, Investigational Phase 3 62-54-4
19 Calcifediol Phase 3 19356-17-3
20 Calcium, Dietary Phase 3,Phase 2,Not Applicable
21 Hydroxycholecalciferols Phase 3,Not Applicable
22 Pharmaceutical Solutions Phase 3
23 Vaccines Phase 2, Phase 3,Phase 3
24 Chelating Agents Phase 3,Phase 2
25 Hormone Antagonists Phase 3,Phase 2,Not Applicable
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
27
Calcitriol Approved, Nutraceutical Phase 2 32222-06-3 134070 5280453
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
29
Niacin Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 59-67-6 938
30
Nicotinamide Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 98-92-0 936
31 Calcimimetic Agents Phase 2,Not Applicable
32 Cinacalcet Hydrochloride Phase 2,Not Applicable
33 Antacids Phase 2
34 Anti-Ulcer Agents Phase 2
35 Dihydroxycholecalciferols Phase 2
36 Gastrointestinal Agents Phase 2
37 Vasoconstrictor Agents Phase 2
38 Hypoglycemic Agents Phase 2
39 insulin Phase 2
40 Insulin, Globin Zinc Phase 2
41 Antimetabolites Phase 1, Phase 2
42 Hypolipidemic Agents Phase 1, Phase 2
43 Lipid Regulating Agents Phase 1, Phase 2
44 Nicotinic Acids Phase 1, Phase 2
45 Vasodilator Agents Phase 1, Phase 2
46 Vitamin B Complex Phase 1, Phase 2
47 Phytosterol Nutraceutical Phase 2
48 Folate Nutraceutical Phase 1, Phase 2
49 Vitamin B3 Nutraceutical Phase 1, Phase 2
50 Vitamin B9 Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
2 Osteopenia and Renal Osteodystrophy: Evaluation and Management Completed NCT00108394 Phase 4 pamidronate
3 Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid
4 Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease Recruiting NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
5 Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients Unknown status NCT00752401 Phase 3 Cholecalciferol;Placebo
6 Impact of a Multidisciplinary Intensive Management Clinic on Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients Unknown status NCT01509690 Phase 2, Phase 3
7 Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination Completed NCT00964210 Phase 3 Licensed quadrivalent HPV vaccine, Gardasil
8 Hyperphosphatemia in Children With Chronic Kidney Disease Not yet recruiting NCT03202407 Phase 3 Calcium acetate and sevelamer hydrochloride
9 12-month Study of AMG 073 in Renal Osteodystrophy Completed NCT00527085 Phase 2 AMG 073;Placebo
10 Regulation of Bone Formation in Renal Osteodystrophy Completed NCT00560300 Phase 2 1 alpha D2;1,25 dihydroxy vitamin D3;Sevelamer HCl;Calcium Carbonate
11 Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis Completed NCT00004340 Phase 2 calcitriol;growth hormone
12 Chewed vs. Crushed Lanthanum Carbonate in Hemodialysis Patients Completed NCT00660530 Phase 2 Lanthanum carbonate;Lanthanum carbonate
13 Vitamin D, Insulin Resistance and Inflammation in ESRD Completed NCT00656032 Phase 2
14 The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysis Patients Completed NCT00508885 Phase 1, Phase 2 Niacinamide;Placebo
15 Kidney Yin/Yang Replenishment on Patients With Renal Osteodystrophy Withdrawn NCT01665651 Phase 2 Yougui granules;Zuogui granules;Yougui granules placebo;Zuogui granules placebo
16 Efficacy of Phosphate Binding in Healthy Volunteers: Chewed Versus Crushed Lanthanum Carbonate Completed NCT00458289 Phase 1 Lanthanum carbonate (chewed vs. crushed)
17 The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patients Completed NCT00316472 Phase 1 Niacinamide
18 Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
19 The Effect of Parathyroidectomy on Renal Function, Endothelial Function, and Blood Pressure Unknown status NCT00452049
20 Renal Osteodystrophy: A Fresh Approach Completed NCT00859612
21 Low Magnitude Mechanical Stimuli Effects on Bone Structure in ESRD Completed NCT00364234 Not Applicable
22 Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease Completed NCT00285467 Not Applicable doxercalciferol;Cholecalciferol
23 The Prevalence of Osteoporosis in Hemodialysis Patients Completed NCT00308828
24 Serum Uremic Toxins and Histological Findings of the Blood Vessels in Dialysis Patients Completed NCT00412139
25 Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation Completed NCT02523209
26 Effectiveness of Probiotics to Treat End Stage Renal Disease Completed NCT02929225 Early Phase 1 Bifid Triple Viable Capsules
27 Renal Osteodystrophy: An Individual Management Approach Recruiting NCT02440581 Not Applicable Alendronate;Teriparatide;Cinacalcet
28 Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency Recruiting NCT02147782
29 Systematic Study of Parameters of Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) Recruiting NCT02556216
30 Effect of Active Vitamin D and Etelcalcetide on Human Osteoclasts in Patients With Chronic Kidney Disease Recruiting NCT03527511
31 Bone Microarchitecture in the Transplant Patient Recruiting NCT02729142 Not Applicable
32 Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients Recruiting NCT02967042 Not Applicable
33 Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia Terminated NCT00374712
34 Treatment of Secondary Hyperparathyroidism in the Uremic Patient Terminated NCT00469599 Not Applicable paricalcitol;alfacalcidol

Search NIH Clinical Center for Renal Osteodystrophy

Cochrane evidence based reviews: chronic kidney disease-mineral and bone disorder

Genetic Tests for Renal Osteodystrophy

Anatomical Context for Renal Osteodystrophy

MalaCards organs/tissues related to Renal Osteodystrophy:

41
Bone, Kidney, Liver, Endothelial, Bone Marrow, Testes, Spinal Cord

Publications for Renal Osteodystrophy

Articles related to Renal Osteodystrophy:

(show top 50) (show all 549)
# Title Authors Year
1
Uremic leontiasis ossea, a rare presentation of severe renal osteodystrophy secondary to hyperparathyroidism. ( 29037869 )
2018
2
Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation. ( 29791896 )
2018
3
Raman Spectroscopic and Microscopic Analysis for Monitoring Renal Osteodystrophy Signatures. ( 29642494 )
2018
4
Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy. ( 29555831 )
2018
5
Role of the Wnt/<i>I^</i>-Catenin Pathway in Renal Osteodystrophy. ( 29808090 )
2018
6
Brown tumor: clinical findings of secondary hyperparathyroidism in patients with renal osteodystrophy. ( 28253186 )
2017
7
Renal Osteodystrophy or Kidney-Induced Osteoporosis? ( 28497212 )
2017
8
Low-intensity Vibration Therapy for Bone Health in Renal Osteodystrophy. ( 28927580 )
2017
9
Renal osteodystrophy presenting as a metabolic superscan on F-18 FDG PET/CT: A case report. ( 29145251 )
2017
10
Renal osteodystrophy in the obesity era: Is metabolic syndrome relevant? ( 28719612 )
2017
11
Bilateral Compressive Optic Neuropathy from Renal Osteodystrophy Caused by Branchio-oto-renal Syndrome Stabilised After Parathyroidectomy. ( 29344072 )
2017
12
Osteocyte dysfunction and renal osteodystrophy: not just calcium and phosphorus anymore. ( 28501301 )
2017
13
PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure. ( 28704404 )
2017
14
Stenosis Before Thrombosis - Intracranial Hypertension from Jugular Foramen Stenosis Secondary to Renal Osteodystrophy. ( 28951273 )
2017
15
Correction of lower limb deformities in children with renal osteodystrophy by guided growth technique. ( 28439314 )
2017
16
Renal Osteodystrophy-Time for Common Nomenclature. ( 28466454 )
2017
17
Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper. ( 28339949 )
2017
18
Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population. ( 27323177 )
2016
19
Myelofibrosis secondary to renal osteodystrophy. ( 28157679 )
2016
20
Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway. ( 26459742 )
2016
21
Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease. ( 27528549 )
2016
22
Challenges of cervical reconstruction for destructive spondyloarthropathy in renal osteodystrophy. ( 27052255 )
2016
23
Correction: Bone Canopies in Pediatric Renal Osteodystrophy. ( 27167735 )
2016
24
Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry. ( 26712809 )
2016
25
Study of renal osteodystrophy in chronic kidney disease. ( 27728490 )
2016
26
Serum phosphorus adds to value of serum parathyroid hormone for assessment of bone turnover in renal osteodystrophy. ( 27191663 )
2016
27
Bone Canopies in Pediatric Renal Osteodystrophy. ( 27045269 )
2016
28
The role of bone biopsy for the diagnosis of renal osteodystrophy: a short overview and future perspectives. ( 27473148 )
2016
29
Emerging role of high resolution imaging in the detection of renal osteodystrophy. ( 27042945 )
2016
30
Turning over renal osteodystrophy dogma: direct actions of FGF23 on osteoblast I^-catenin pathway. ( 27312441 )
2016
31
Multiple periradicular radiolucencies mimicking endodontic lesions in renal osteodystrophy of the mandible: a case report. ( 26199041 )
2015
32
Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease. ( 25784153 )
2015
33
A rare manifestation of renal osteodystrophy in a non-compliant child on hemodialysis: Answers. ( 25966786 )
2015
34
A rare manifestation of renal osteodystrophy in a non-compliant hemodialysis child: Questions. ( 25966785 )
2015
35
Bilateral spontaneous fracturing of the femoral neck in a patient with renal osteodystrophy. ( 26229859 )
2014
36
Is renal osteodystrophy a neglected entity? ( 24596811 )
2014
37
Oral manifestations in a renal osteodystrophy patient - a case report with review of literature. ( 25302278 )
2014
38
Bilateral hip arthritis in a case of renal osteodystrophy. ( 24554674 )
2014
39
Effects of unfractionated heparin on renal osteodystrophy and vascular calcification in chronic kidney disease rats. ( 24145307 )
2014
40
Computed tomography and magnetic resonance imaging of maxillofacial lesions in renal osteodystrophy. ( 24902107 )
2014
41
Renal osteodystrophy in children: pathogenesis, diagnosis and treatment. ( 24553631 )
2014
42
Anti-Sclerostin Antibody Treatment in a Rat Model of Progressive Renal Osteodystrophy. ( 25407607 )
2014
43
Severe renal osteodystrophy in early infancy. ( 26052218 )
2014
44
Bisphosphonate therapy in renal osteodystrophy--a review. ( 22760876 )
2013
45
Superscan caused by renal osteodystrophy: Observed on 18F FDG PET/CT scan. ( 24379542 )
2013
46
Switching between parathormone (PTH) assays: the impact on the diagnosis of renal osteodystrophy. ( 23241601 )
2013
47
Recent advances in the noninvasive diagnosis of renal osteodystrophy. ( 23802194 )
2013
48
Severe renal osteodystrophy in a pediatric patient with end-stage renal disease: Sagliker syndrome? ( 23026501 )
2013
49
Bone biopsy in renal osteodystrophy: continued insights into a complex disease. ( 23318700 )
2013
50
Prevalence of renal osteodystrophy in african hemodialysis patients. ( 24282802 )
2013

Variations for Renal Osteodystrophy

Expression for Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for Renal Osteodystrophy

GO Terms for Renal Osteodystrophy

Cellular components related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 BGLAP CALCA FGF23 IGFBP4 IGFBP5 PTH
2 endoplasmic reticulum lumen GO:0005788 9.46 BGLAP FGF23 IGFBP4 IGFBP5
3 extracellular space GO:0005615 9.23 BGLAP CALCA FGF23 IGFBP4 IGFBP5 PTH

Biological processes related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.87 CALCA FGF23 PTH TNFRSF11B
2 response to drug GO:0042493 9.8 BGLAP PTH TNFRSF11B
3 aging GO:0007568 9.79 BGLAP CALCA IGFBP5
4 ossification GO:0001503 9.65 BGLAP CASR SOST
5 negative regulation of osteoblast differentiation GO:0045668 9.62 FGF23 IGFBP5
6 cellular protein metabolic process GO:0044267 9.62 CALCA FGF23 IGFBP4 IGFBP5
7 regulation of glucose metabolic process GO:0010906 9.61 IGFBP4 IGFBP5
8 negative regulation of ossification GO:0030279 9.6 CALCA SOST
9 regulation of bone mineralization GO:0030500 9.59 BGLAP FGF23
10 vasodilation GO:0042311 9.58 CALCA CASR
11 response to vitamin D GO:0033280 9.58 BGLAP PTH
12 positive regulation of ossification GO:0045778 9.56 CALCA PTH
13 response to inorganic substance GO:0010035 9.55 BGLAP TNFRSF11B
14 vitamin D metabolic process GO:0042359 9.54 FGF23 VDR
15 negative regulation of bone resorption GO:0045779 9.52 CALCA TNFRSF11B
16 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.51 IGFBP4 IGFBP5
17 response to magnesium ion GO:0032026 9.49 FGF23 TNFRSF11B
18 cellular response to parathyroid hormone stimulus GO:0071374 9.46 FGF23 SOST
19 cellular calcium ion homeostasis GO:0006874 9.46 CALCA CASR PTH VDR
20 type B pancreatic cell proliferation GO:0044342 9.43 IGFBP4 IGFBP5
21 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.4 IGFBP4 IGFBP5
22 response to fibroblast growth factor GO:0071774 9.37 CASR PTH
23 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.26 FGF23 VDR
24 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
25 skeletal system development GO:0001501 9.02 BGLAP IGFBP4 PTH TNFRSF11B VDR

Molecular functions related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.26 IGFBP4 IGFBP5
2 insulin-like growth factor binding GO:0005520 9.16 IGFBP4 IGFBP5
3 insulin-like growth factor I binding GO:0031994 8.96 IGFBP4 IGFBP5
4 insulin-like growth factor II binding GO:0031995 8.62 IGFBP4 IGFBP5

Sources for Renal Osteodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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