MCID: RNL011
MIFTS: 49

Renal Osteodystrophy

Categories: Bone diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Osteodystrophy

MalaCards integrated aliases for Renal Osteodystrophy:

Name: Renal Osteodystrophy 12 77 56 15 17 74
Renal Rickets 12 77 54 74
Chronic Kidney Disease-Mineral and Bone Disorder 45

Classifications:



External Ids:

Disease Ontology 12 DOID:13068
ICD9CM 36 588.0
MeSH 45 D012080
NCIt 51 C114827
SNOMED-CT 69 16726004
ICD10 34 N25.0

Summaries for Renal Osteodystrophy

MalaCards based summary : Renal Osteodystrophy, also known as renal rickets, is related to osteitis fibrosa and osteonecrosis. An important gene associated with Renal Osteodystrophy is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Parathyroid hormone synthesis, secretion and action. The drugs Sevelamer and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and endothelial, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Wikipedia : 77 Renal osteodystrophy is currently defined as an alteration of bone morphology in patients with chronic... more...

Related Diseases for Renal Osteodystrophy

Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 osteitis fibrosa 32.0 BGLAP CALCA CASR PTH
2 osteonecrosis 30.2 BGLAP PTH TNFRSF11B
3 uremia 30.1 CASR PTH TNFRSF11B VDR
4 pseudohypoparathyroidism 30.1 BGLAP PTH
5 rickets 30.1 BGLAP FGF23 PTH VDR
6 kidney disease 29.9 CASR FGF23 PTH TNFRSF11B VDR
7 hyperostosis 29.8 FGF23 SOST TNFRSF11B
8 hyperparathyroidism 29.6 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
9 osteomalacia 29.5 BGLAP CALCA CASR FGF23 PTH VDR
10 primary hyperparathyroidism 29.3 BGLAP CALCA CASR FGF23 PTH VDR
11 chronic kidney failure 29.2 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
12 bone resorption disease 28.9 BGLAP CALCA PTH SOST TNFRSF11B VDR
13 bone disease 28.5 BGLAP CALCA CASR FGF23 PTH SOST
14 osteoporosis 27.7 BGLAP CALCA CASR FGF23 IGFBP4 PTH
15 abderhalden kaufmann lignac syndrome 11.1
16 secondary hyperparathyroidism 10.4
17 axial osteomalacia 10.3 BGLAP PTH
18 extraskeletal chondroma 10.3 BGLAP PTH
19 hypercalciuria, absorptive, 2 10.3 CASR VDR
20 hypocalciuric hypercalcemia, familial, type i 10.3 CASR PTH
21 hypocalciuric hypercalcemia, familial, type ii 10.3 CASR PTH
22 hypocalciuric hypercalcemia, familial, type iii 10.3 CASR PTH
23 hypoparathyroidism, familial isolated 10.3 CASR PTH
24 familial isolated hyperparathyroidism 10.3 CASR PTH
25 familial hypocalciuric hypercalcemia 10.3 CASR PTH
26 xanthinuria, type i 10.3 CASR VDR
27 end stage renal failure 10.2
28 spondylosis 10.2 PTH VDR
29 multicentric carpotarsal osteolysis syndrome 10.2 BGLAP TNFRSF11B
30 oncogenic osteomalacia 10.2 FGF23 PTH
31 nephrolithiasis, calcium oxalate 10.2 CASR VDR
32 hypophosphatemic rickets, x-linked dominant 10.2 FGF23 PTH
33 metal metabolism disorder 10.2 CASR PTH
34 thyroid gland disease 10.2 CALCA PTH
35 pulmonary alveolar microlithiasis 10.2 FGF23 PTH
36 slipped capital femoral epiphysis 10.2
37 epiphysiolysis of the hip 10.2
38 pseudohypoparathyroidism, type ib 10.2 BGLAP PTH
39 nontoxic goiter 10.2 BGLAP CALCA
40 chondrocalcinosis 10.2 CASR TNFRSF11B
41 hypophosphatemic rickets, x-linked recessive 10.2 FGF23 VDR
42 idiopathic hypercalciuria 10.1 BGLAP CASR VDR
43 van buchem disease 10.1 SOST VDR
44 kummell's disease 10.1 SOST TNFRSF11B
45 cloacogenic carcinoma 10.1 CALCA PTH
46 paget disease of bone 5, juvenile-onset 10.1 CALCA TNFRSF11B
47 sclerosteosis 10.1 SOST VDR
48 mccune-albright syndrome 10.1 BGLAP FGF23
49 osteopetrosis, autosomal dominant 2 10.1 BGLAP SOST
50 myelofibrosis 10.1

Comorbidity relations with Renal Osteodystrophy via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to Renal Osteodystrophy

Symptoms & Phenotypes for Renal Osteodystrophy

MGI Mouse Phenotypes related to Renal Osteodystrophy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 CASR FGF23 IGFBP4 IGFBP5 PTH SOST
2 endocrine/exocrine gland MP:0005379 9.73 CASR FGF23 IGFBP4 IGFBP5 PTH VDR
3 limbs/digits/tail MP:0005371 9.35 FGF23 PTH SOST TNFRSF11B VDR
4 skeleton MP:0005390 9.1 CASR FGF23 PTH SOST TNFRSF11B VDR

Drugs & Therapeutics for Renal Osteodystrophy

Drugs for Renal Osteodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevelamer Approved Phase 4,Phase 3,Phase 2 52757-95-6
2
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Not Applicable 9002-64-6
3
Pamidronate Approved Phase 4 40391-99-9 4674
4
Zoledronic Acid Approved Phase 4 118072-93-8 68740
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
6
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-14-6 5280793
7
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
8
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 5280795 6221
9 Ergocalciferols Phase 4,Phase 3,Phase 2,Not Applicable
10 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 1 alpha-hydroxyergocalciferol Phase 4,Phase 2,Not Applicable
12 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Vitamin D2 Phase 4,Phase 3,Phase 2,Not Applicable
15 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
16 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
19 Calciferol Phase 4,Phase 3,Phase 2,Not Applicable
20 Diphosphonates Phase 4
21
Calcium Carbonate Approved, Investigational Phase 3,Phase 2 471-34-1
22
Calcium acetate Approved, Investigational Phase 3 62-54-4
23
carbamide peroxide Approved Phase 3 124-43-6
24
Calcifediol Approved, Nutraceutical Phase 3 19356-17-3 5283731 6433735
25 Pharmaceutical Solutions Phase 3
26 Hydroxycholecalciferols Phase 3,Not Applicable
27 Vaccines Phase 2, Phase 3,Phase 3
28 Immunologic Factors Phase 3
29 Hormone Antagonists Phase 3,Phase 2,Not Applicable
30 Chelating Agents Phase 3,Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
32
Cinacalcet Approved Phase 2,Not Applicable 226256-56-0 156419
33
Nicotinamide Approved, Investigational Phase 1, Phase 2,Phase 2 98-92-0 936
34
Calcitriol Approved, Nutraceutical Phase 2 32222-06-3 5280453 134070
35
Niacin Approved, Investigational, Nutraceutical Phase 1, Phase 2,Phase 2 59-67-6 938
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
37 Calcimimetic Agents Phase 2,Not Applicable
38 Dihydroxycholecalciferols Phase 2
39 Vasoconstrictor Agents Phase 2
40 Anti-Ulcer Agents Phase 2
41 Phytosterol Phase 2
42 Antacids Phase 2
43 Gastrointestinal Agents Phase 2
44 Hypoglycemic Agents Phase 2
45 Insulin, Globin Zinc Phase 2
46 insulin Phase 2
47 Vitamin B3 Phase 1, Phase 2
48 Nicotinic Acids Phase 1, Phase 2
49 Vitamin B Complex Phase 1, Phase 2
50 Folate Phase 1, Phase 2

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
2 Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
3 Osteopenia and Renal Osteodystrophy: Evaluation and Management Completed NCT00108394 Phase 4 pamidronate
4 Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid
5 Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients Unknown status NCT00752401 Phase 3 Cholecalciferol;Placebo
6 Impact of a Multidisciplinary Intensive Management Clinic on Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients Unknown status NCT01509690 Phase 2, Phase 3
7 Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination Completed NCT00964210 Phase 3 Licensed quadrivalent HPV vaccine, Gardasil
8 Hyperphosphatemia in Children With Chronic Kidney Disease Not yet recruiting NCT03202407 Phase 3 Calcium acetate and sevelamer hydrochloride
9 12-month Study of AMG 073 in Renal Osteodystrophy Completed NCT00527085 Phase 2 AMG 073;Placebo
10 Regulation of Bone Formation in Renal Osteodystrophy Completed NCT00560300 Phase 2 1 alpha D2;1,25 dihydroxy vitamin D3;Sevelamer HCl;Calcium Carbonate
11 Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis Completed NCT00004340 Phase 2 calcitriol;growth hormone
12 Chewed vs. Crushed Lanthanum Carbonate in Hemodialysis Patients Completed NCT00660530 Phase 2 Lanthanum carbonate;Lanthanum carbonate
13 Vitamin D, Insulin Resistance and Inflammation in ESRD Completed NCT00656032 Phase 2
14 The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysis Patients Completed NCT00508885 Phase 1, Phase 2 Niacinamide;Placebo
15 The Effect of Etelcalcetide on CKD-MBD Recruiting NCT03960437 Phase 2 Etelcalcetide
16 The Effects of 12-months of Denosumab on Bone Density in Prevalent Kidney Transplant Recipients Not yet recruiting NCT03960554 Phase 2 Denosumab Inj 60 mg/ml
17 Kidney Yin/Yang Replenishment on Patients With Renal Osteodystrophy Withdrawn NCT01665651 Phase 2 Yougui granules;Zuogui granules;Yougui granules placebo;Zuogui granules placebo
18 Efficacy of Phosphate Binding in Healthy Volunteers: Chewed Versus Crushed Lanthanum Carbonate Completed NCT00458289 Phase 1 Lanthanum carbonate (chewed vs. crushed)
19 The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patients Completed NCT00316472 Phase 1 Niacinamide
20 Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
21 The Effect of Parathyroidectomy on Renal Function, Endothelial Function, and Blood Pressure Unknown status NCT00452049
22 Renal Osteodystrophy: A Fresh Approach Completed NCT00859612
23 Low Magnitude Mechanical Stimuli Effects on Bone Structure in ESRD Completed NCT00364234 Not Applicable
24 Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease Completed NCT00285467 Not Applicable doxercalciferol;Cholecalciferol
25 The Prevalence of Osteoporosis in Hemodialysis Patients Completed NCT00308828
26 Serum Uremic Toxins and Histological Findings of the Blood Vessels in Dialysis Patients Completed NCT00412139
27 Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation Completed NCT02523209
28 Effectiveness of Probiotics to Treat End Stage Renal Disease Completed NCT02929225 Early Phase 1 Bifid Triple Viable Capsules
29 Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function Recruiting NCT03716128
30 Renal Osteodystrophy: An Individual Management Approach Recruiting NCT02440581 Not Applicable Alendronate;Teriparatide;Cinacalcet
31 Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency Recruiting NCT02147782
32 Systematic Study of Parameters of Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) Recruiting NCT02556216
33 Effect of Active Vitamin D and Etelcalcetide on Human Osteoclasts in Patients With Chronic Kidney Disease Recruiting NCT03527511
34 Bone Microarchitecture in the Transplant Patient Recruiting NCT02729142 Not Applicable
35 Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients Recruiting NCT02967042 Not Applicable
36 Pathogenesis of Compromised Bone Quality and Mechanics in Chronic Kidney Disease Recruiting NCT03626246
37 Hypocalcemia in Infants and Children Not yet recruiting NCT03685877
38 Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia Terminated NCT00374712
39 Treatment of Secondary Hyperparathyroidism in the Uremic Patient Terminated NCT00469599 Not Applicable paricalcitol;alfacalcidol

Search NIH Clinical Center for Renal Osteodystrophy

Cochrane evidence based reviews: chronic kidney disease-mineral and bone disorder

Genetic Tests for Renal Osteodystrophy

Anatomical Context for Renal Osteodystrophy

MalaCards organs/tissues related to Renal Osteodystrophy:

42
Bone, Kidney, Endothelial, Bone Marrow, Spinal Cord, Cortex, Thyroid

Publications for Renal Osteodystrophy

Articles related to Renal Osteodystrophy:

(show top 50) (show all 817)
# Title Authors Year
1
Factors and Outcome of Renal Osteodystrophy-Associated Initial Fragility Fracture in End-Stage Renal Disease Patients. ( 31019925 )
2019
2
The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic rats. ( 30801205 )
2019
3
New pathogenic insights inform therapeutic target development for renal osteodystrophy. ( 30665565 )
2019
4
Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression. ( 30365152 )
2019
5
Tertiary Hyperparathyroidism With Renal Osteodystrophy on 18F-Fluorocholine PET/CT. ( 30153138 )
2018
6
Uremic leontiasis ossea, a rare presentation of severe renal osteodystrophy secondary to hyperparathyroidism. ( 29037869 )
2018
7
Stenosis Before Thrombosis: Intracranial Hypertension from Jugular Foramen Stenosis Secondary to Renal Osteodystrophy. ( 28951273 )
2018
8
Evaluation of renal osteodystrophy in the dental clinic by assessment of mandibular and phalangeal cortical indices. ( 30484132 )
2018
9
Radiological manifestations of renal osteodystrophy in the orofacial region: a case report and literature review. ( 30484027 )
2018
10
Impaired osteocyte maturation in the pathogenesis of renal osteodystrophy. ( 30348285 )
2018
11
Simultaneous, Non-traumatic, Bilateral Neck Femur Fractures in Uremic Renal Osteodystrophy: A Report of Three Cases and Literature Review. ( 30167423 )
2018
12
Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy. ( 29808090 )
2018
13
Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation. ( 29791896 )
2018
14
Raman Spectroscopic and Microscopic Analysis for Monitoring Renal Osteodystrophy Signatures. ( 29642494 )
2018
15
Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy. ( 29555831 )
2018
16
Brown tumor: clinical findings of secondary hyperparathyroidism in patients with renal osteodystrophy. ( 28253186 )
2017
17
Bilateral Compressive Optic Neuropathy from Renal Osteodystrophy Caused by Branchio-oto-renal Syndrome Stabilised After Parathyroidectomy. ( 29344072 )
2017
18
Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper. ( 28339949 )
2017
19
Correction of lower limb deformities in children with renal osteodystrophy by guided growth technique. ( 28439314 )
2017
20
Renal Osteodystrophy-Time for Common Nomenclature. ( 28466454 )
2017
21
Osteocyte dysfunction and renal osteodystrophy: not just calcium and phosphorus anymore. ( 28501301 )
2017
22
Renal osteodystrophy presenting as a metabolic superscan on F-18 FDG PET/CT: A case report. ( 29145251 )
2017
23
Low-intensity Vibration Therapy for Bone Health in Renal Osteodystrophy. ( 28927580 )
2017
24
Renal osteodystrophy in the obesity era: Is metabolic syndrome relevant? ( 28719612 )
2017
25
PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure. ( 28704404 )
2017
26
Renal Osteodystrophy or Kidney-Induced Osteoporosis? ( 28497212 )
2017
27
Myelofibrosis secondary to renal osteodystrophy. ( 28157679 )
2016
28
A rare manifestation of renal osteodystrophy in a non-compliant hemodialysis child: Questions. ( 25966785 )
2016
29
A rare manifestation of renal osteodystrophy in a non-compliant child on hemodialysis: Answers. ( 25966786 )
2016
30
Multiple periradicular radiolucencies mimicking endodontic lesions in renal osteodystrophy of the mandible: a case report. ( 26199041 )
2016
31
Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway. ( 26459742 )
2016
32
Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry. ( 26712809 )
2016
33
Emerging role of high-resolution imaging in the detection of renal osteodystrophy. ( 27042945 )
2016
34
Bone Canopies in Pediatric Renal Osteodystrophy. ( 27045269 )
2016
35
Challenges of cervical reconstruction for destructive spondyloarthropathy in renal osteodystrophy. ( 27052255 )
2016
36
Correction: Bone Canopies in Pediatric Renal Osteodystrophy. ( 27167735 )
2016
37
Serum phosphorus adds to value of serum parathyroid hormone for assessment of bone turnover in renal osteodystrophy. ( 27191663 )
2016
38
Turning over renal osteodystrophy dogma: direct actions of FGF23 on osteoblast β-catenin pathway. ( 27312441 )
2016
39
Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population. ( 27323177 )
2016
40
The role of bone biopsy for the diagnosis of renal osteodystrophy: a short overview and future perspectives. ( 27473148 )
2016
41
Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease. ( 27528549 )
2016
42
Simultaneous bilateral femoral neck fracture in a patient with renal osteodystrophy. ( 29942841 )
2016
43
Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy. ( 25407607 )
2015
44
Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease. ( 25784153 )
2015
45
Severe renal osteodystrophy in early infancy. ( 26052218 )
2014
46
Bilateral spontaneous fracturing of the femoral neck in a patient with renal osteodystrophy. ( 26229859 )
2014
47
Oral manifestations in a renal osteodystrophy patient - a case report with review of literature. ( 25302278 )
2014
48
Computed tomography and magnetic resonance imaging of maxillofacial lesions in renal osteodystrophy. ( 24902107 )
2014
49
Is renal osteodystrophy a neglected entity? ( 24596811 )
2014
50
Bilateral hip arthritis in a case of renal osteodystrophy. ( 24554674 )
2014

Variations for Renal Osteodystrophy

Expression for Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for Renal Osteodystrophy

GO Terms for Renal Osteodystrophy

Cellular components related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 BGLAP CALCA FGF23 IGFBP4 IGFBP5 PTH
2 endoplasmic reticulum lumen GO:0005788 9.46 BGLAP FGF23 IGFBP4 IGFBP5
3 extracellular space GO:0005615 9.23 BGLAP CALCA FGF23 IGFBP4 IGFBP5 PTH

Biological processes related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.86 CALCA FGF23 PTH TNFRSF11B
2 response to drug GO:0042493 9.8 BGLAP PTH TNFRSF11B
3 ossification GO:0001503 9.65 BGLAP CASR SOST
4 negative regulation of osteoblast differentiation GO:0045668 9.62 FGF23 IGFBP5
5 cellular protein metabolic process GO:0044267 9.62 CALCA FGF23 IGFBP4 IGFBP5
6 aging GO:0007568 9.61 BGLAP IGFBP5
7 regulation of glucose metabolic process GO:0010906 9.6 IGFBP4 IGFBP5
8 regulation of bone mineralization GO:0030500 9.59 BGLAP FGF23
9 response to vitamin D GO:0033280 9.58 BGLAP PTH
10 negative regulation of bone resorption GO:0045779 9.55 CALCA TNFRSF11B
11 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 IGFBP4 IGFBP5
12 response to inorganic substance GO:0010035 9.52 BGLAP TNFRSF11B
13 response to magnesium ion GO:0032026 9.51 FGF23 TNFRSF11B
14 vitamin D metabolic process GO:0042359 9.49 FGF23 VDR
15 cellular response to parathyroid hormone stimulus GO:0071374 9.46 FGF23 SOST
16 type B pancreatic cell proliferation GO:0044342 9.43 IGFBP4 IGFBP5
17 phosphate ion homeostasis GO:0055062 9.4 FGF23 PTH
18 response to fibroblast growth factor GO:0071774 9.37 CASR PTH
19 cellular calcium ion homeostasis GO:0006874 9.33 CASR PTH VDR
20 bone mineralization GO:0030282 9.31 BGLAP
21 negative regulation of ossification GO:0030279 9.28 SOST
22 vasodilation GO:0042311 9.27 CASR
23 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.26 FGF23 VDR
24 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
25 skeletal system development GO:0001501 8.92 BGLAP PTH TNFRSF11B VDR

Molecular functions related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.26 IGFBP4 IGFBP5
2 insulin-like growth factor binding GO:0005520 9.16 IGFBP4 IGFBP5
3 insulin-like growth factor I binding GO:0031994 8.96 IGFBP4 IGFBP5
4 insulin-like growth factor II binding GO:0031995 8.62 IGFBP4 IGFBP5

Sources for Renal Osteodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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