MCID: RNL019
MIFTS: 19

Renal Pelvis Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Renal Pelvis Transitional Cell Carcinoma

MalaCards integrated aliases for Renal Pelvis Transitional Cell Carcinoma:

Name: Renal Pelvis Transitional Cell Carcinoma 12 15
Urothelial Cell Carcinoma of Renal Pelvis 12
Renal Pelvis Urothelial Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5974
NCIt 50 C7355
UMLS 73 C0238410

Summaries for Renal Pelvis Transitional Cell Carcinoma

MalaCards based summary : Renal Pelvis Transitional Cell Carcinoma, also known as urothelial cell carcinoma of renal pelvis, is related to transitional cell carcinoma and infiltrating renal pelvis transitional cell carcinoma. An important gene associated with Renal Pelvis Transitional Cell Carcinoma is UPK3A (Uroplakin 3A). The drugs Alkylating Agents and Mitomycins have been mentioned in the context of this disorder. Related phenotype is renal/urinary system.

Related Diseases for Renal Pelvis Transitional Cell Carcinoma

Diseases related to Renal Pelvis Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 29.1 KRT7 UPK3A
2 infiltrating renal pelvis transitional cell carcinoma 12.3
3 adenocarcinoma 9.9
4 glandular cystitis 9.6 KRT7 UPK3A
5 ovarian benign neoplasm 9.6 KRT7 UPK3A
6 vulval paget's disease 9.6 KRT7 UPK3A
7 chronic cystitis 9.6 KRT7 UPK3A
8 vulva adenocarcinoma 9.6 KRT7 UPK3A
9 renal pelvis carcinoma 9.5 KRT7 UPK3A
10 urethral diverticulum 9.5 KRT7 UPK3A
11 vulva cancer 9.4 KRT7 UPK3A
12 ovarian brenner tumor 9.3 KRT7 UPK3A
13 bladder urothelial carcinoma 9.0 KRT7 UPK3A

Graphical network of the top 20 diseases related to Renal Pelvis Transitional Cell Carcinoma:



Diseases related to Renal Pelvis Transitional Cell Carcinoma

Symptoms & Phenotypes for Renal Pelvis Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Renal Pelvis Transitional Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.62 KRT7 UPK3A

Drugs & Therapeutics for Renal Pelvis Transitional Cell Carcinoma

Drugs for Renal Pelvis Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Alkylating Agents Phase 3
2 Mitomycins Phase 3
3 Nucleic Acid Synthesis Inhibitors Phase 3
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Antibodies Phase 2,Phase 1
7 Immunoglobulins Phase 2,Phase 1
8 Antibodies, Monoclonal Phase 2,Phase 1
9
nivolumab Approved Phase 1 946414-94-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study Recruiting NCT02793128 Phase 3 MitoGelâ„¢ instillations
2 Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer Recruiting NCT03237780 Phase 2 Atezolizumab;Eribulin Mesylate
3 Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma Not yet recruiting NCT03513952 Phase 2 Atezolizumab
4 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate

Search NIH Clinical Center for Renal Pelvis Transitional Cell Carcinoma

Genetic Tests for Renal Pelvis Transitional Cell Carcinoma

Anatomical Context for Renal Pelvis Transitional Cell Carcinoma

Publications for Renal Pelvis Transitional Cell Carcinoma

Articles related to Renal Pelvis Transitional Cell Carcinoma:

# Title Authors Year
1
Spontaneously arising concurrent ileocaecal adenocarcinoma and renal pelvis transitional cell carcinoma in a rhesus macaque (Macaca mulatta). ( 24016782 )
2013
2
Surgical treatment of inferior vena cava invasion in patients with renal pelvis transitional cell carcinoma by use of human cadaveric aorta. ( 22536474 )
2012
3
Hypertrophic osteopathy associated with renal pelvis transitional cell carcinoma in a dog. ( 17824162 )
2007

Variations for Renal Pelvis Transitional Cell Carcinoma

Cosmic variations for Renal Pelvis Transitional Cell Carcinoma:

9
(show all 42)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 10
2 COSM44696 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.409C>T p.L137L 17:7675203-7675203 10
3 COSM43582 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.454C>T p.P152S 17:7675158-7675158 10
4 COSM10650 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.529C>T p.P177S 17:7675083-7675083 10
5 COSM10943 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.841G>C p.D281H 17:7673779-7673779 10
6 COSM44568 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.840A>G p.R280R 17:7673780-7673780 10
7 COSM10722 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.853G>A p.E285K 17:7673767-7673767 10
8 COSM10656 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.742C>T p.R248W 17:7674221-7674221 10
9 COSM43778 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.713G>T p.C238F 17:7674250-7674250 10
10 COSM10742 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.578A>G p.H193R 17:7674953-7674953 10
11 COSM10659 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.817C>T p.R273C 17:7673803-7673803 10
12 COSM44086 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.417G>A p.K139K 17:7675195-7675195 10
13 COSM43680 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.523C>T p.R175C 17:7675089-7675089 10
14 COSM10724 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.839G>C p.R280T 17:7673781-7673781 10
15 COSM43616 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.704A>G p.N235S 17:7674259-7674259 10
16 COSM43687 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.641A>G p.H214R 17:7674890-7674890 10
17 COSM10867 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.797G>A p.G266E 17:7673823-7673823 10
18 COSM11491 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.743G>C p.R248P 17:7674220-7674220 10
19 COSM44700 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.556G>A p.D186N 17:7675056-7675056 10
20 COSM11524 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.730G>T p.G244C 17:7674233-7674233 10
21 COSM10645 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.527G>T p.C176F 17:7675085-7675085 10
22 COSM10704 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 10
23 COSM43871 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.746G>T p.R249M 17:7674217-7674217 10
24 COSM44705 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.697C>T p.H233Y 17:7674266-7674266 10
25 COSM44706 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.420C>T p.T140T 17:7675192-7675192 10
26 COSM44520 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.424C>T p.P142S 17:7675188-7675188 10
27 COSM11333 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 10
28 COSM43963 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.396G>C p.K132N 17:7675216-7675216 10
29 COSM1717802 STAG2 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.2026-1G>T p.? 23:124065875-124065875 10
30 COSM760 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 10
31 COSM763 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 10
32 COSM13570 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.331A>G p.K111E 3:179199156-179199156 10
33 COSM13385 MSH6 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1190A>G p.Y397C 2:47799173-47799173 10
34 COSM521 KRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.35G>A p.G12D 12:25245350-25245350 10
35 COSM520 KRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.35G>T p.G12V 12:25245350-25245350 10
36 COSM489 HRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.38G>T p.G13V 11:534285-534285 10
37 COSM499 HRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.182A>G p.Q61R 11:533874-533874 10
38 COSM715 FGFR3 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.746C>G p.S249C 4:1801841-1801841 10
39 COSM714 FGFR3 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.742C>T p.R248C 4:1801837-1801837 10
40 COSM5667 CTNNB1 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.134C>T p.S45F 3:41224646-41224646 10
41 COSM476 BRAF urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 10
42 COSM4167105 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.2026-1G>T p.? 23:124065875-124065875 10

Expression for Renal Pelvis Transitional Cell Carcinoma

Search GEO for disease gene expression data for Renal Pelvis Transitional Cell Carcinoma.

Pathways for Renal Pelvis Transitional Cell Carcinoma

GO Terms for Renal Pelvis Transitional Cell Carcinoma

Sources for Renal Pelvis Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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