MCID: RNL019
MIFTS: 30

Renal Pelvis Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Renal Pelvis Transitional Cell Carcinoma

MalaCards integrated aliases for Renal Pelvis Transitional Cell Carcinoma:

Name: Renal Pelvis Transitional Cell Carcinoma 12 15
Urothelial Cell Carcinoma of Renal Pelvis 12
Renal Pelvis Urothelial Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5974
NCIt 50 C7355
UMLS 70 C0238410

Summaries for Renal Pelvis Transitional Cell Carcinoma

MalaCards based summary : Renal Pelvis Transitional Cell Carcinoma, also known as urothelial cell carcinoma of renal pelvis, is related to transitional cell carcinoma and adenocarcinoma. An important gene associated with Renal Pelvis Transitional Cell Carcinoma is UPK3A (Uroplakin 3A), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Cisplatin and Atezolizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and small intestine.

Related Diseases for Renal Pelvis Transitional Cell Carcinoma

Diseases related to Renal Pelvis Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 29.7 UPK3A MSH2 MLH1 KRT7
2 adenocarcinoma 29.2 MSH6 MSH2 MLH1 KRT7
3 infiltrating renal pelvis transitional cell carcinoma 11.7
4 kidney cancer 10.1
5 posttransplant acute limbic encephalitis 10.1
6 vulva adenocarcinoma 10.1 UPK3A KRT7
7 vulval paget's disease 10.1 UPK3A KRT7
8 urethral diverticulum 10.1 UPK3A KRT7
9 gastric squamous cell carcinoma 10.1 UPK3A KRT7
10 papillary transitional carcinoma 10.1 UPK3A KRT7
11 ureteral benign neoplasm 10.1 UPK3A KRT7
12 transitional papilloma 10.1 UPK3A KRT7
13 glandular cystitis 10.1 UPK3A KRT7
14 cystitis 10.1 UPK3A KRT7
15 ovarian brenner tumor 10.1 UPK3A KRT7
16 bladder clear cell adenocarcinoma 10.1 UPK3A KRT7
17 transverse colon cancer 10.1 MLH1 KRT7
18 epithelioid cell synovial sarcoma 10.0 UPK3A KRT7
19 urethra clear cell adenocarcinoma 10.0 UPK3A KRT7
20 bladder adenocarcinoma 10.0 UPK3A KRT7
21 chronic cystitis 10.0 UPK3A KRT7
22 bartholin's gland adenocarcinoma 10.0 UPK3A KRT7
23 bladder sarcoma 10.0 UPK3A KRT7
24 adenomyoma 10.0 MLH1 KRT7
25 monophasic synovial sarcoma 10.0 MLH1 KRT7
26 vulva cancer 10.0 UPK3A KRT7
27 renal pelvis carcinoma 10.0 MSH6 KRT7
28 villous adenoma 10.0 MLH1 KRT7
29 endometrioid ovary carcinoma 10.0 MSH6 MLH1
30 uterine body mixed cancer 9.9 MSH6 MLH1
31 mucinous adenocarcinoma 9.9 MLH1 KRT7
32 colorectal cancer 2 9.9 MSH2 MLH1
33 rectum signet ring adenocarcinoma 9.9 MSH2 MLH1
34 ovarian clear cell carcinoma 9.9 MLH1 KRT7
35 intracranial meningioma 9.9 MSH2 MLH1
36 endometrial adenocarcinoma 9.9 MLH1 KRT7
37 ascending colon cancer 9.9 MSH2 MLH1
38 lower lip cancer 9.9 MSH2 MLH1
39 bilateral breast cancer 9.9 MSH6 MLH1
40 cervical adenoma malignum 9.9 MSH2 KRT7
41 silent pituitary adenoma 9.8 MSH6 MSH2
42 ileum cancer 9.8 MSH2 KRT7
43 melanocytic nevus syndrome, congenital 9.8 MSH2 MLH1
44 esophagus sarcoma 9.8 MSH6 MSH2
45 cervical adenosarcoma 9.8 MSH6 MSH2
46 t-cell non-hodgkin lymphoma 9.8 MSH6 MSH2
47 hydronephrosis 9.8 UPK3A KRT7
48 familial colorectal cancer 9.8 MSH2 MLH1
49 attenuated familial adenomatous polyposis 9.8 MSH6 MSH2
50 keratoacanthoma 9.8 MSH2 MLH1

Graphical network of the top 20 diseases related to Renal Pelvis Transitional Cell Carcinoma:



Diseases related to Renal Pelvis Transitional Cell Carcinoma

Symptoms & Phenotypes for Renal Pelvis Transitional Cell Carcinoma

Drugs & Therapeutics for Renal Pelvis Transitional Cell Carcinoma

Drugs for Renal Pelvis Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
3 Tubulin Modulators Phase 2
4 Antimitotic Agents Phase 2
5 Immunoglobulins Phase 2
6 Antibodies Phase 2
7 Halichondrin B Phase 2
8 Antibodies, Monoclonal Phase 2
9 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Phase 2 Trial to Evaluate the Safety and Efficacy of Eribulin Mesylate in Combination With Atezolizumab Compared to Atezolizumab Alone in Subjects With Locally Advanced or Metastatic Transitional Cell Urothelial Cancer Where Cisplatin-Based Treatment is Not an Option Recruiting NCT03237780 Phase 2 Atezolizumab;Eribulin Mesylate

Search NIH Clinical Center for Renal Pelvis Transitional Cell Carcinoma

Genetic Tests for Renal Pelvis Transitional Cell Carcinoma

Anatomical Context for Renal Pelvis Transitional Cell Carcinoma

MalaCards organs/tissues related to Renal Pelvis Transitional Cell Carcinoma:

40
Colon, Breast, Small Intestine, Skin, Kidney, Ovary, Appendix

Publications for Renal Pelvis Transitional Cell Carcinoma

Articles related to Renal Pelvis Transitional Cell Carcinoma:

(show all 12)
# Title Authors PMID Year
1
Spontaneously arising concurrent ileocaecal adenocarcinoma and renal pelvis transitional cell carcinoma in a rhesus macaque (Macaca mulatta). 61
24016782 2013
2
Surgical treatment of inferior vena cava invasion in patients with renal pelvis transitional cell carcinoma by use of human cadaveric aorta. 61
22536474 2012
3
Ureteric angioplasty balloon placement to increase localised dosage of BCG for renal pelvis TCC. 61
22558818 2012
4
Hypertrophic osteopathy associated with renal pelvis transitional cell carcinoma in a dog. 61
17824162 2007
5
Pseudo-Meigs' syndrome associated to renal pelvis tumor. 61
15992429 2005
6
Transitional cell carcinoma of the renal pelvis with extension into the inferior vena cava: a report of two cases. 61
12926523 2003
7
Familial transitional cell carcinoma among the population of Iceland. 61
9112497 1997
8
[Synchronous manifestation of bladder inverted papilloma and transitional carcinoma of the renal pelvis]. 61
8588726 1995
9
Laparoscopic nephroureterectomy for upper tract transitional cell cancer: the Washington University experience. 61
7637105 1995
10
Spontaneous neoplasms in aged Sprague-Dawley rats. 61
1444814 1992
11
[Neoplasm invasion of the renal vein by transitional cell carcinoma of the kidney pelvis]. 61
2378269 1990
12
Tumor production in germ-free rats fed 5-nitrofurans. 61
6692348 1984

Variations for Renal Pelvis Transitional Cell Carcinoma

Expression for Renal Pelvis Transitional Cell Carcinoma

Search GEO for disease gene expression data for Renal Pelvis Transitional Cell Carcinoma.

Pathways for Renal Pelvis Transitional Cell Carcinoma

Pathways related to Renal Pelvis Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.4 MSH6 MSH2 MLH1
2
Show member pathways
12.34 MSH6 MSH2 MLH1
3
Show member pathways
12.23 MSH6 MSH2 MLH1
4 11.97 MSH6 MSH2 MLH1
5 11.65 MSH6 MSH2 MLH1
6
Show member pathways
11.43 MSH6 MSH2
7
Show member pathways
11.31 MSH6 MSH2 MLH1
8 11.1 MSH6 MSH2
9
Show member pathways
11.05 MSH2 MLH1
10 11 MSH6 MSH2 MLH1
11
Show member pathways
10.97 MSH2 MLH1
12 10.26 MSH6 MSH2 MLH1

GO Terms for Renal Pelvis Transitional Cell Carcinoma

Cellular components related to Renal Pelvis Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.33 MSH6 MSH2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.8 MSH6 MSH2 MLH1

Biological processes related to Renal Pelvis Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.71 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.7 MSH6 MSH2 MLH1
3 determination of adult lifespan GO:0008340 9.51 MSH6 MSH2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.5 MSH6 MSH2 MLH1
5 negative regulation of DNA recombination GO:0045910 9.49 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.46 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MSH2 MLH1
9 mismatch repair GO:0006298 9.43 MSH6 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.4 MSH6 MSH2
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MSH2 MLH1
12 isotype switching GO:0045190 9.33 MSH6 MSH2 MLH1
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.13 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MSH6 MSH2 MLH1

Molecular functions related to Renal Pelvis Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.69 MSH6 MSH2 MLH1
2 enzyme binding GO:0019899 9.67 MSH6 MSH2 MLH1
3 ATPase activity GO:0016887 9.61 MSH6 MSH2 MLH1
4 single-stranded DNA binding GO:0003697 9.54 MSH2 MLH1
5 damaged DNA binding GO:0003684 9.52 MSH6 MSH2
6 ADP binding GO:0043531 9.48 MSH6 MSH2
7 DNA-dependent ATPase activity GO:0008094 9.46 MSH6 MSH2
8 four-way junction DNA binding GO:0000400 9.4 MSH6 MSH2
9 MutLalpha complex binding GO:0032405 9.37 MSH6 MSH2
10 oxidized purine DNA binding GO:0032357 9.32 MSH6 MSH2
11 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
12 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
13 mismatched DNA binding GO:0030983 9.13 MSH6 MSH2 MLH1
14 guanine/thymine mispair binding GO:0032137 8.8 MSH6 MSH2 MLH1

Sources for Renal Pelvis Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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