MCID: RNL019
MIFTS: 22

Renal Pelvis Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Renal Pelvis Transitional Cell Carcinoma

MalaCards integrated aliases for Renal Pelvis Transitional Cell Carcinoma:

Name: Renal Pelvis Transitional Cell Carcinoma 12 15
Urothelial Cell Carcinoma of Renal Pelvis 12
Renal Pelvis Urothelial Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5974
NCIt 51 C7355
UMLS 74 C0238410

Summaries for Renal Pelvis Transitional Cell Carcinoma

MalaCards based summary : Renal Pelvis Transitional Cell Carcinoma, also known as urothelial cell carcinoma of renal pelvis, is related to transitional cell carcinoma and infiltrating renal pelvis transitional cell carcinoma. An important gene associated with Renal Pelvis Transitional Cell Carcinoma is UPK3A (Uroplakin 3A). The drugs Cisplatin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related phenotype is renal/urinary system.

Related Diseases for Renal Pelvis Transitional Cell Carcinoma

Diseases related to Renal Pelvis Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 30.4 KRT7 UPK3A
2 infiltrating renal pelvis transitional cell carcinoma 12.7
3 adenocarcinoma 10.0
4 glandular cystitis 9.8 KRT7 UPK3A
5 vulval paget's disease 9.8 KRT7 UPK3A
6 vulvar disease 9.8 KRT7 UPK3A
7 chronic cystitis 9.8 KRT7 UPK3A
8 vulva adenocarcinoma 9.8 KRT7 UPK3A
9 renal pelvis carcinoma 9.7 KRT7 UPK3A
10 urethral diverticulum 9.7 KRT7 UPK3A
11 vulva cancer 9.7 KRT7 UPK3A
12 ovarian brenner tumor 9.6 KRT7 UPK3A
13 bladder urothelial carcinoma 9.5 KRT7 UPK3A

Graphical network of the top 20 diseases related to Renal Pelvis Transitional Cell Carcinoma:



Diseases related to Renal Pelvis Transitional Cell Carcinoma

Symptoms & Phenotypes for Renal Pelvis Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Renal Pelvis Transitional Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.62 KRT7 UPK3A

Drugs & Therapeutics for Renal Pelvis Transitional Cell Carcinoma

Drugs for Renal Pelvis Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3
3
Gemcitabine Approved Phase 3 95058-81-4 60750
4 Immunoglobulins Phase 3,Phase 2,Phase 1
5 Immunologic Factors Phase 3,Phase 2,Phase 1
6 Immunoglobulin G Phase 3,Phase 2,Phase 1
7 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
8 Antibodies Phase 3,Phase 2,Phase 1
9 Antineoplastic Agents, Immunological Phase 3,Phase 2,Phase 1
10 Anti-Bacterial Agents Phase 3
11 Alkylating Agents Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 3
13 Nucleic Acid Synthesis Inhibitors Phase 3
14 Mitomycins Phase 3
15 Antimetabolites Phase 3,Phase 2
16 Anti-Infective Agents Phase 3,Phase 2
17 Endothelial Growth Factors Phase 3
18 Angiogenesis Inhibitors Phase 3
19 Angiogenesis Modulating Agents Phase 3
20 Antimetabolites, Antineoplastic Phase 3,Phase 2
21 Antiviral Agents Phase 3,Phase 2
22 Mitogens Phase 3
23 Immunosuppressive Agents Phase 3,Phase 2
24
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
25
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
26
Pembrolizumab Approved Phase 2 1374853-91-4
27
Fludarabine Approved Phase 2 75607-67-9, 21679-14-1 30751
28
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
29
Vidarabine Approved, Investigational Phase 2 24356-66-9 21704 32326
30
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
31 Halichondrin B Phase 2
32 Antimitotic Agents Phase 2
33 Protein Kinase Inhibitors Phase 2
34
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
35 Analgesics Phase 2
36 Vidarabine Phosphate Phase 2
37 Peripheral Nervous System Agents Phase 2
38 Anti-Retroviral Agents Phase 2
39 Analgesics, Non-Narcotic Phase 2
40 Anti-HIV Agents Phase 2
41 Antirheumatic Agents Phase 2
42 Interleukin-2 Phase 2
43 Antineoplastic Agents, Alkylating Phase 2
44
Ipilimumab Approved Phase 1 477202-00-9
45
Durvalumab Approved, Investigational Phase 1 1428935-60-7
46
nivolumab Approved Phase 1 946414-94-4
47
Tremelimumab Investigational Phase 1 745013-59-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study Active, not recruiting NCT02793128 Phase 3 MitoGel™ instillations
2 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
3 Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma Recruiting NCT03513952 Phase 2 Atezolizumab
4 Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer Recruiting NCT03237780 Phase 2 Atezolizumab;Eribulin Mesylate
5 Erlotinib Hydrochloride in Treating Participants With Muscle Invasive or Recurrent Urothelial Cancer Active, not recruiting NCT00749892 Phase 2 Erlotinib Hydrochloride
6 Adoptive Cell Therapy With (LN-145) in Combination With Pembrolizumab in Treating Patients With Unresectable or Metastatic Transitional Cell Cancer Who Have Failed Cisplatin-Based Chemotherapy Not yet recruiting NCT03935347 Phase 2 Cyclophosphamide;Fludarabine;Fludarabine Phosphate
7 Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery Recruiting NCT02812420 Phase 1
8 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib;Cabozantinib S-malate

Search NIH Clinical Center for Renal Pelvis Transitional Cell Carcinoma

Genetic Tests for Renal Pelvis Transitional Cell Carcinoma

Anatomical Context for Renal Pelvis Transitional Cell Carcinoma

MalaCards organs/tissues related to Renal Pelvis Transitional Cell Carcinoma:

42
Endothelial

Publications for Renal Pelvis Transitional Cell Carcinoma

Articles related to Renal Pelvis Transitional Cell Carcinoma:

# Title Authors Year
1
Spontaneously arising concurrent ileocaecal adenocarcinoma and renal pelvis transitional cell carcinoma in a rhesus macaque (Macaca mulatta). ( 24016782 )
2013
2
Surgical treatment of inferior vena cava invasion in patients with renal pelvis transitional cell carcinoma by use of human cadaveric aorta. ( 22536474 )
2012
3
Hypertrophic osteopathy associated with renal pelvis transitional cell carcinoma in a dog. ( 17824162 )
2007

Variations for Renal Pelvis Transitional Cell Carcinoma

Cosmic variations for Renal Pelvis Transitional Cell Carcinoma:

9 (show all 42)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
2 COSM44696 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.409C>T p.L137L 17:7675203-7675203 0
3 COSM44520 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.424C>T p.P142S 17:7675188-7675188 0
4 COSM43582 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.454C>T p.P152S 17:7675158-7675158 0
5 COSM10650 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.529C>T p.P177S 17:7675083-7675083 0
6 COSM10943 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.841G>C p.D281H 17:7673779-7673779 0
7 COSM44568 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.840A>G p.R280R 17:7673780-7673780 0
8 COSM10722 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.853G>A p.E285K 17:7673767-7673767 0
9 COSM10656 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
10 COSM43963 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.396G>C p.K132N 17:7675216-7675216 0
11 COSM43778 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.713G>T p.C238F 17:7674250-7674250 0
12 COSM10742 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.578A>G p.H193R 17:7674953-7674953 0
13 COSM10659 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
14 COSM43680 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.523C>T p.R175C 17:7675089-7675089 0
15 COSM44086 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.417G>A p.K139K 17:7675195-7675195 0
16 COSM10724 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.839G>C p.R280T 17:7673781-7673781 0
17 COSM43616 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.704A>G p.N235S 17:7674259-7674259 0
18 COSM10867 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.797G>A p.G266E 17:7673823-7673823 0
19 COSM43687 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.641A>G p.H214R 17:7674890-7674890 0
20 COSM11491 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.743G>C p.R248P 17:7674220-7674220 0
21 COSM44700 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.556G>A p.D186N 17:7675056-7675056 0
22 COSM11524 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.730G>T p.G244C 17:7674233-7674233 0
23 COSM10645 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.527G>T p.C176F 17:7675085-7675085 0
24 COSM10704 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
25 COSM43871 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.746G>T p.R249M 17:7674217-7674217 0
26 COSM44705 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.697C>T p.H233Y 17:7674266-7674266 0
27 COSM44706 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.420C>T p.T140T 17:7675192-7675192 0
28 COSM11333 TP53 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
29 COSM1717802 STAG2 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.2026-1G>T p.? 23:124065875-124065875 0
30 COSM760 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 0
31 COSM763 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 0
32 COSM13570 PIK3CA urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.331A>G p.K111E 3:179199156-179199156 0
33 COSM13385 MSH6 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1190A>G p.Y397C 2:47799173-47799173 0
34 COSM520 KRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.35G>T p.G12V 12:25245350-25245350 0
35 COSM521 KRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.35G>A p.G12D 12:25245350-25245350 0
36 COSM489 HRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.38G>T p.G13V 11:534285-534285 0
37 COSM499 HRAS urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.182A>G p.Q61R 11:533874-533874 0
38 COSM715 FGFR3 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.746C>G p.S249C 4:1801841-1801841 0
39 COSM714 FGFR3 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.742C>T p.R248C 4:1801837-1801837 0
40 COSM5667 CTNNB1 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.134C>T p.S45F 3:41224646-41224646 0
41 COSM476 BRAF urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 0
42 COSM4167105 urinary tract,renal pelvis,carcinoma,transitional cell carcinoma c.2026-1G>T p.? 23:124065875-124065875 0

Expression for Renal Pelvis Transitional Cell Carcinoma

Search GEO for disease gene expression data for Renal Pelvis Transitional Cell Carcinoma.

Pathways for Renal Pelvis Transitional Cell Carcinoma

GO Terms for Renal Pelvis Transitional Cell Carcinoma

Sources for Renal Pelvis Transitional Cell Carcinoma

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10 dbSNP
11 DGIdb
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63 PubMed
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70 SNOMED-CT via HPO
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72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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