MCID: RNL012
MIFTS: 39

Renal Tuberculosis

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Renal Tuberculosis

MalaCards integrated aliases for Renal Tuberculosis:

Name: Renal Tuberculosis 12 15
Tuberculosis, Renal 44 73
Tuberculosis of Kidney 12
Tuberculosis Renal 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9733
ICD9CM 35 016.0 016.00
MeSH 44 D014398
NCIt 50 C123020
SNOMED-CT 68 186236001 44323002
UMLS 73 C0041328

Summaries for Renal Tuberculosis

Disease Ontology : 12 An urogenital tuberculosis that results in formation of granulomas located in kidney.

MalaCards based summary : Renal Tuberculosis, also known as tuberculosis, renal, is related to xanthogranulomatous pyelonephritis and renal hypertension. An important gene associated with Renal Tuberculosis is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. The drugs Methotrexate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and bone, and related phenotype is cardiovascular system.

Related Diseases for Renal Tuberculosis

Diseases related to Renal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 xanthogranulomatous pyelonephritis 30.0 LYZ NCF4 PKDREJ
2 renal hypertension 29.4 EDN1 REN
3 renovascular hypertension 29.2 EDN1 REN
4 chronic kidney failure 29.2 B2M EDN1 REN
5 kidney disease 29.0 B2M EDN1 PKDREJ REN
6 chronic pyelonephritis 10.7 B2M PKDREJ
7 amyloid tumor 10.7 B2M PKDREJ
8 diffuse glomerulonephritis 10.5 B2M LYZ
9 hereditary amyloidosis 10.5 B2M LYZ
10 small intestine lymphoma 10.5 B2M CTSL
11 kidney papillary necrosis 10.5 LYZ REN
12 retinitis pigmentosa 7 10.4 B2M LYZ
13 dermis tumor 10.4 LYZ VCAN
14 urinary tract obstruction 10.4 B2M PKDREJ REN
15 urogenital tuberculosis 10.4 HCN4 NCF4 SLC35A2
16 malignant essential hypertension 10.3 ENSG00000264813 REN
17 anterior scleritis 10.3 B2M MRAP
18 malignant renovascular hypertension 10.3 EDN1 REN
19 familial glucocorticoid deficiency 10.3 MRAP REN
20 fiedler's myocarditis 10.3 CTSL ENSG00000264813
21 malignant secondary hypertension 10.3 EDN1 REN
22 perinephritis 10.3 EDN1 REN
23 malignant hypertension 10.2 EDN1 REN
24 acute salpingitis 10.1 LYZ MRAP
25 orthostatic proteinuria 10.1 B2M ENSG00000264813 REN
26 retinal hemangioblastoma 10.1 LYZ PKDREJ
27 purulent endophthalmitis 10.1 CTSL MRAP
28 hepatorenal syndrome 10.1 EDN1 REN
29 hepatic vascular disease 10.0 EDN1 REN
30 apnea, obstructive sleep 10.0 EDN1 REN
31 autosomal dominant polycystic kidney disease 9.9 EDN1 PKDREJ REN
32 pyelitis 9.9 B2M LYZ PKDREJ REN
33 pyelonephritis 9.9
34 idiopathic hypercalciuria 9.8 EDN1 REN
35 renal cell carcinoma, nonpapillary 9.7
36 amyloidosis, familial visceral 9.7 B2M LYZ
37 arteries, anomalies of 9.7 EDN1 ENSG00000264813 REN
38 bladder cancer 9.7
39 hydronephrosis 9.7
40 cystic kidney disease 9.7
41 polycystic kidney disease 9.7
42 hypersensitivity reaction type iv disease 9.6 ENSG00000264813 LYZ MRAP
43 vernal conjunctivitis 9.5 B2M OGA
44 systemic lupus erythematosus 9.5
45 aging 9.5
46 asthma 9.5
47 hepatitis 9.5
48 sinusitis 9.5
49 interstitial nephritis 9.5
50 nephrosclerosis 9.5

Graphical network of the top 20 diseases related to Renal Tuberculosis:



Diseases related to Renal Tuberculosis

Symptoms & Phenotypes for Renal Tuberculosis

MGI Mouse Phenotypes related to Renal Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 B2M EDN1 HCN4 LYZ REN VCAN

Drugs & Therapeutics for Renal Tuberculosis

Drugs for Renal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved 1959-05-2, 59-05-2 126941
2
Etanercept Approved, Investigational 185243-69-0
3
leucovorin Approved, Nutraceutical 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5 Analgesics
6 interferons
7 Folic Acid Antagonists
8 Gastrointestinal Agents
9 Analgesics, Non-Narcotic
10 Dermatologic Agents
11 Nucleic Acid Synthesis Inhibitors
12 Peripheral Nervous System Agents
13 Vitamin B Complex
14 Immunosuppressive Agents
15 Anti-Infective Agents
16 Interferon-gamma
17 Anti-Inflammatory Agents
18 Anti-Inflammatory Agents, Non-Steroidal
19 Antirheumatic Agents
20 Antimetabolites
21 Antiviral Agents
22 Antimetabolites, Antineoplastic
23 Folate Nutraceutical
24 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Surveillance and Follow-up for Latent Tuberculosis Infection and Risk of Developing Active Tuberculosis in Patients Receiving Long-term Dialysis Completed NCT01311999
2 Characterize Patients With Moderately Active Rheumatoid Arthritis (RA) Completed NCT01557322 methotrexate (MTX)

Search NIH Clinical Center for Renal Tuberculosis

Cochrane evidence based reviews: tuberculosis, renal

Genetic Tests for Renal Tuberculosis

Anatomical Context for Renal Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Renal Tuberculosis:

19
Kidney

MalaCards organs/tissues related to Renal Tuberculosis:

41
Kidney, Bone, Testes

Publications for Renal Tuberculosis

Articles related to Renal Tuberculosis:

(show top 50) (show all 340)
# Title Authors Year
1
Renal Tuberculosis Following Intravesical Bacillus Calmette-GuAcrin for High-grade Non-muscle-invasive Bladder Cancer. ( 28577928 )
2017
2
Gross Hematuria Is More Common in Male and Older Patients with Renal Tuberculosis in China: A Single-Center 15-Year Clinical Experience. ( 28343213 )
2017
3
Renal Tuberculosis in a 9 Months Old: Case Report and Review of the Literature. ( 28462170 )
2017
4
Risk Factors Related with Retroperitoneal Laparoscopic Converted to Open Nephrectomy for Nonfunctioning Renal Tuberculosis. ( 28358254 )
2017
5
Renal tuberculosis with lobar calcification. ( 27051143 )
2016
6
Chronic kidney disease related to renal tuberculosis: a case report. ( 27384842 )
2016
7
Pseudotumor presentation of renal tuberculosis mimicking renal cell carcinoma: A rare entity. ( 27635298 )
2016
8
Renal tuberculosis presenting as acute pyelonephritis - A rarity. ( 27865246 )
2016
9
Renal Tuberculosis Presenting as a Mass Lesion in a Two-year-old Girl: Report of a rare case. ( 26909199 )
2016
10
Open surgery versus retroperitoneal laparoscopic nephrectomy for renal tuberculosis: a retrospective study of 120 patients. ( 27917313 )
2016
11
Systemic lupus erythematosus accompanying with renal tuberculosis: a case report. ( 26221395 )
2015
12
A kidney's ingenious path to trimillennar preservation: Renal tuberculosis in an Egyptian mummy? ( 28802970 )
2015
13
Is Urinary Lipoarabinomannan the Result of Renal Tuberculosis? Assessment of the Renal Histology in an Autopsy Cohort of Ugandan HIV-Infected Adults. ( 25897661 )
2015
14
Renal tuberculosis tends to be low symptoms: how to improve the diagnosis and treatment of renal tuberculosis. ( 25791732 )
2015
15
Dual Time Point (18)F-FDG PET/CT Imaging Identifies Bilateral Renal Tuberculosis in an Immunocompromised Patient with an Unknown Primary Malignancy. ( 26157590 )
2015
16
Reply: Challenges in the diagnosis of renal tuberculosis. ( 26362964 )
2015
17
Renal tuberculosis: a case report. ( 26017107 )
2015
18
Challenges in the diagnosis of renal tuberculosis. ( 26362963 )
2015
19
Clinical analysis of retroperitoneoscopic nephroureterectomy for renal tuberculosis. ( 29063010 )
2015
20
Discovery of Renal Tuberculosis in a Partial Nephrectomy Specimen Done for Renal Tumor. ( 26793504 )
2015
21
Ureteral calculi combined with xanthogranulomatous pyelonephritis mimicking renal tuberculosis in a male child. ( 25458052 )
2014
22
Concomitant urothelial cancer and renal tuberculosis. ( 25133009 )
2014
23
Usefulness of interferon-gamma release assay in diagnosis of renal tuberculosis. ( 25342574 )
2014
24
Renal tuberculosis and iliopsoas abscess: Two case reports. ( 24926373 )
2014
25
Renal tuberculosis in the modern era. ( 23303798 )
2013
26
Concurrent renal tuberculosis and renal cell carcinoma: A coincidental finding. ( 23814430 )
2013
27
Renal tuberculosis presenting as thigh abscess. ( 24426644 )
2013
28
Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II. ( 23986619 )
2013
29
Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part I. ( 23986618 )
2013
30
Psoas Abscess Secondary to Renal Tuberculosis in a Middle-aged Woman. ( 24255765 )
2013
31
Fever of unknown origin (FUO) and a renal mass: renal cell carcinoma, renal tuberculosis, renal malakoplakia, or xanthogranulomatous pyelonephritis? ( 22658892 )
2012
32
Renal tuberculosis presenting as a complicated renal cyst. ( 23206799 )
2012
33
Paraspinal sinuses? Do remember renal tuberculosis. ( 22605826 )
2012
34
Unusual presentation of renal tuberculosis in type 2 diabetes. ( 23238207 )
2012
35
Pulmonary and cutaneous sarcoidosis in a treated case of renal tuberculosis. ( 22421674 )
2012
36
Renal tuberculosis in infancy. ( 21731237 )
2011
37
Images in clinical medicine: Renal tuberculosis. ( 21992143 )
2011
38
Unusual presentation of renal tuberculosis. ( 21525583 )
2011
39
Rapid diagnosis in early stage renal tuberculosis by real-time polymerase chain reaction on renal biopsy specimens. ( 20132626 )
2010
40
Renal tuberculosis. ( 21219817 )
2010
41
Magnetic resonance imaging as a clue to successful diagnosis of renal tuberculosis: a case report. ( 19918351 )
2009
42
A renal tuberculosis case: could Chinese medicine play a role? ( 19678787 )
2009
43
Renal tuberculosis in a thirteen-month-old female infant. ( 19633528 )
2009
44
Safe re-initiation of infliximab in a patient with renal tuberculosis. ( 19604451 )
2009
45
[Expression of lymphotactin in renal tuberculosis]. ( 18177623 )
2008
46
Surgical management of renal tuberculosis. ( 19468471 )
2008
47
Ultrasonographic diagnosis and typing of renal tuberculosis. ( 18269447 )
2008
48
An unusual presentation: renal tuberculosis. ( 19112536 )
2008
49
Radiological findings in renal tuberculosis: a report from northwest of Iran. ( 18087128 )
2008
50
Renal tuberculosis in adult polycystic kidney disease: report of 2 cases and review of the literature. ( 17478782 )
2007

Variations for Renal Tuberculosis

Expression for Renal Tuberculosis

Search GEO for disease gene expression data for Renal Tuberculosis.

Pathways for Renal Tuberculosis

Pathways related to Renal Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 VCAN XCL1

GO Terms for Renal Tuberculosis

Cellular components related to Renal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 B2M CTSL EDN1 LYZ REN VCAN
2 extracellular space GO:0005615 9.17 B2M CTSL EDN1 LYZ REN VCAN

Biological processes related to Renal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 B2M LYZ VCAN
2 retina homeostasis GO:0001895 9.32 B2M LYZ
3 positive regulation of neutrophil chemotaxis GO:0090023 9.16 EDN1 XCL1
4 positive regulation of T cell mediated cytotoxicity GO:0001916 8.96 B2M XCL1
5 positive regulation of T cell cytokine production GO:0002726 8.62 B2M XCL1

Sources for Renal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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