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MCID: RNL007
MIFTS: 51

Renal Tubular Acidosis

Categories: Blood diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Renal Tubular Acidosis

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MalaCards integrated aliases for Renal Tubular Acidosis:

Name: Renal Tubular Acidosis 39 12 77 54 30 15 74
Acidosis, Renal Tubular 45
Acidosis Renal Tubular 56

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14219
MeSH 45 D000141
NCIt 51 C28129
SNOMED-CT 69 1776003
ICD10 34 N25.89
UMLS 74 C0001126
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Summaries for Renal Tubular Acidosis

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Disease Ontology : 12 A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine.

MalaCards based summary : Renal Tubular Acidosis, also known as acidosis, renal tubular, is related to renal tubular acidosis, distal, autosomal recessive and renal tubular acidosis, distal. An important gene associated with Renal Tubular Acidosis is ATP6V1B1 (ATPase H+ Transporting V1 Subunit B1), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include Kidney, kidney and bone, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 77 Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body... more...

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Related Diseases for Renal Tubular Acidosis

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Diseases in the Renal Tubular Acidosis family:

Renal Tubular Acidosis Iii

Diseases related to Renal Tubular Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 renal tubular acidosis, distal, autosomal recessive 34.5 ATP6V0A4 ATP6V1B1 SLC4A1
2 renal tubular acidosis, distal 34.5 ATP6V0A4 ATP6V1B1 SLC4A1
3 renal tubular acidosis, distal, with hemolytic anemia 34.5 SLC4A1 WDR72
4 renal tubular acidosis, distal, autosomal dominant 34.4 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
5 osteopetrosis, autosomal recessive 3 33.9 ATP6V0A4 ATP6V1B1 CA2
6 nephrocalcinosis 32.3 ATP6V0A4 ATP6V1B1 CA2 OCRL SLC4A1
7 medullary sponge kidney 31.0 ATP6V0A4 ATP6V1B1
8 nephrolithiasis 29.9 ATP6V0A4 ATP6V1B1 SLC26A1 SLC26A6
9 metabolic acidosis 29.8 ATP6V0A4 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A3
10 renal tubular acidosis, distal, with progressive nerve deafness 13.0
11 renal tubular acidosis, proximal, with ocular abnormalities and mental retardation 12.8
12 slc4a1-associated distal renal tubular acidosis 12.8
13 renal tubular acidosis, proximal 12.7
14 renal tubular acidosis, distal, type 3 12.4
15 renal tubular acidosis iii 12.4
16 neuroaxonal dystrophy renal tubular acidosis 12.4
17 renal tubular acidosis, distal, with nephrocalcinosis, short stature, mental retardation, and distinctive facies 12.3
18 renal tubular acidosis, distal, type 4 12.3
19 autosomal dominant proximal renal tubular acidosis 12.3
20 hypoparathyroidism, sensorineural deafness, and renal disease 11.5
21 arthrogryposis, renal dysfunction, and cholestasis 1 11.5
22 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.4
23 say syndrome 11.2
24 dent disease 2 11.2
25 lowe oculocerebrorenal syndrome 11.2
26 glomerulopathy with fibronectin deposits 2 11.2
27 amelogenesis imperfecta hypoplastic type, ig 11.2
28 osteomalacia 10.6
29 osteopetrosis 10.6
30 sjogren syndrome 10.6
31 hypokalemia 10.5
32 biliary cirrhosis, primary, 1 10.5
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
34 primary biliary cirrhosis 10.5
35 diabetes insipidus 10.5
36 primary biliary cholangitis 10.5
37 hyperparathyroidism 10.5
38 diabetes insipidus, nephrogenic, autosomal 10.5
39 systemic lupus erythematosus 10.5
40 rickets 10.5
41 fanconi syndrome 10.5
42 hypothyroidism 10.5
43 lupus erythematosus 10.5
44 hypokalemic periodic paralysis, type 1 10.4
45 hepatitis 10.4
46 sensorineural hearing loss 10.4
47 ovalocytosis, southeast asian 10.4
48 bone disease 10.4
49 liver disease 10.4
50 thyroiditis 10.4

Graphical network of the top 20 diseases related to Renal Tubular Acidosis:



Diseases related to Renal Tubular Acidosis
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Symptoms & Phenotypes for Renal Tubular Acidosis

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MGI Mouse Phenotypes related to Renal Tubular Acidosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ATP6V0A4 ATP6V1B1 CA2 OCRL REN SLC12A7
2 renal/urinary system MP:0005367 9.73 ATP6V0A4 ATP6V1B1 CA2 OCRL REN SLC12A7
3 skeleton MP:0005390 9.17 ATP6V0A4 ATP6V0D2 ATP6V1B1 CA2 SLC4A4 SLC4A7
Sources

Drugs & Therapeutics for Renal Tubular Acidosis

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Drugs for Renal Tubular Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
4 Hormones Phase 4,Phase 2,Phase 3
5 Natriuretic Agents Phase 4,Phase 3,Not Applicable
6 diuretics Phase 4,Phase 3,Not Applicable
7 Liposomal amphotericin B Phase 4
8 Anti-Bacterial Agents Phase 4
9 Mineralocorticoids Phase 4
10 Anti-Infective Agents Phase 4
11 Mineralocorticoid Receptor Antagonists Phase 4
12 Antiparasitic Agents Phase 4
13 Hormone Antagonists Phase 4
14 Antifungal Agents Phase 4
15 Diuretics, Potassium Sparing Phase 4
16 Antiprotozoal Agents Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18
Sodium Citrate Approved, Investigational Phase 3,Not Applicable 68-04-2
19
Potassium Citrate Approved, Investigational, Vet_approved Phase 3,Not Applicable
20
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
21
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 77-92-9 311
22 Calcium, Dietary Phase 2, Phase 3,Not Applicable
23 Bone Density Conservation Agents Phase 2, Phase 3
24 Expectorants Phase 3,Not Applicable
25 Respiratory System Agents Phase 3,Not Applicable
26 Citrate Phase 3,Not Applicable
27
Fludrocortisone Approved, Investigational 127-31-1 31378
28
Furosemide Approved, Vet_approved 54-31-9 3440
29
Acetazolamide Approved, Vet_approved Not Applicable 59-66-5 1986
30
carbamide peroxide Approved 124-43-6
31
Topiramate Approved Not Applicable 97240-79-4 5284627
32 Antibodies
33 Immunoglobulins
34 Anti-Inflammatory Agents
35 Sodium Potassium Chloride Symporter Inhibitors
36 Anticonvulsants Not Applicable
37 Anticoagulants Not Applicable
38 Chelating Agents Not Applicable
39 Carbonic Anhydrase Inhibitors Not Applicable
40 Hypoglycemic Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
2 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
3 Study Evaluating Subjects With Distal Renal Tubular Acidosis Recruiting NCT03644706 Phase 3 ADV7103;Placebos
4 Extension Study in Primary Distal Renal Tubular Acidosis Not yet recruiting NCT03831152 Phase 3 ADV7103
5 Renal Tubular Acidosis in Incident Renal Transplant Recipients Unknown status NCT01283880
6 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Unknown status NCT02287363
7 Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients Completed NCT02392091
8 Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis Completed NCT01690039 Furosemide-Fludrocortisone-Test (test for urinary acidification)
9 A Study Of Mircera In Patients With Kidney Disease Who Are Not On Dialysis Completed NCT02490514
10 Metabolic Consequences of Heterozygous Hereditary Fructose Intolerance Completed NCT02979106 Not Applicable
11 Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones Completed NCT00120731 Not Applicable Potassium Citrate;Acetazolamide
12 Incidence of Renal Tubular Acidosis in Nephrology Unit in Assiut University Childern Hospital Not yet recruiting NCT03268460
13 Use of Sodium Bicarbonate in Patients Treated With Topiramate Not yet recruiting NCT03354507 Not Applicable
14 Genetic Study of Nephrolithiasis in Gouty Diathesis Terminated NCT00149305

Search NIH Clinical Center for Renal Tubular Acidosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: acidosis, renal tubular

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Genetic Tests for Renal Tubular Acidosis

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Genetic tests related to Renal Tubular Acidosis:

# Genetic test Affiliating Genes
1 Renal Tubular Acidosis 30
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Anatomical Context for Renal Tubular Acidosis

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MalaCards organs/tissues related to Renal Tubular Acidosis:

42
Kidney, Bone, Testes, Thyroid, Brain, Colon, Eye
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Renal Tubular Acidosis:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Proximal Tubule Proximal Tubule Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Renal Tubular Acidosis

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Articles related to Renal Tubular Acidosis:

(show top 50) (show all 1146)
# Title Authors Year
1
Transient distal renal tubular acidosis in a dog with gastric-dilatation-volvulus. ( 30705453 )
2019
2
Renal Tubular Acidosis. ( 30454739 )
2019
3
Re: Incomplete Distal Renal Tubular Acidosis and Kidney Stones. ( 30759664 )
2019
4
Treatment and long-term outcome in primary distal renal tubular acidosis. ( 30773598 )
2019
5
Ibuprofen-Induced Renal Tubular Acidosis. ( 30775637 )
2019
6
Presence of serum autoantibodies to vacuolar H+ -ATPase in patients with renal tubular acidosis. ( 30821427 )
2019
7
Distal renal tubular acidosis in two children with acquired hypothyroidism. ( 29716758 )
2018
8
Primary Autosomal Recessive Distal Renal Tubular Acidosis Caused by a Common Homozygous SLC4A1 Mutation in Two Lao Families. ( 29573245 )
2018
9
Regional anesthesia is safe and effective for lower limb orthopedic surgery in patient with renal tubular acidosis and hypokalemia. ( 29643635 )
2018
10
Distal renal tubular acidosis in SjAPgren's syndrome. ( 29657223 )
2018
11
Topiramate-Associated Renal Tubular Acidosis. ( 29782342 )
2018
12
Sjogren's with distal renal tubular acidosis complicating pregnancy. ( 29361865 )
2018
13
Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review. ( 29134448 )
2018
14
Anesthetic considerations in a parturient with renal tubular acidosis and hypothyroidism undergoing cesarean delivery. ( 29029882 )
2018
15
Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. ( 29666732 )
2018
16
Primary distal renal tubular acidosis: novel findings in patients studied by next-generation sequencing. ( 29437164 )
2018
17
Systemic lupus erythematosus with SjAPgren's syndrome and renal tubular acidosis presenting as nephrogenic diabetes insipidus. ( 29657217 )
2018
18
SLC4A4 compound heterozygous mutations in exon-intron boundary regions presenting with severe proximal renal tubular acidosis and extrarenal symptoms coexisting with Turner's syndrome: a case report. ( 29914390 )
2018
19
Osteopetrosis with renal tubular acidosis and cerebral calcification. ( 29571443 )
2018
20
Bilateral Proximal Femur Fractures in a Patient with Renal Tubular Acidosis: A Case Report. ( 29725512 )
2018
21
Distal renal tubular acidosis. Clinical manifestations in patients with different underlying gene mutations. ( 29725771 )
2018
22
A Ser725Arg mutation in Band 3 abolishes transport function and leads to anemia and renal tubular acidosis. ( 29483102 )
2018
23
Molecular mechanisms of cutis laxa and distal renal tubular acidosis-causing mutations in V-ATPase<i>a</i>subunits, ATP6V0A2 and ATP6V0A4. ( 29311258 )
2018
24
Genotype-Phenotype Analysis in Pediatric Patients with Distal Renal Tubular Acidosis. ( 29627839 )
2018
25
Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance. ( 29024829 )
2018
26
Targeted Deletion of the Ncoa7 Gene Results in Incomplete Distal Renal Tubular Acidosis in Mice. ( 29384414 )
2018
27
An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma. ( 30381523 )
2018
28
Alkaptonuria, a new association of distal renal tubular acidosis. ( 30152443 )
2018
29
Ibuprofen Abuse-A Case of Rhabdomyolysis, Hypokalemia, and Hypophosphatemia With Drug-Induced Mixed Renal Tubular Acidosis. ( 30197993 )
2018
30
Case Report: Recurrent hypokalemic periodic paralysis associated with distal renal tubular acidosis (type 1) and hypothyroidism secondary to thyroiditis. ( 30647907 )
2018
31
Sjögren's, Renal Tubular Acidosis and Osteomalacia - An Asian Indian Series. ( 30123372 )
2018
32
Pendred, pendrin, pseudohypoaldosteronism type II, and renal tubular acidosis. ( 30143066 )
2018
33
A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis. ( 30146013 )
2018
34
Low Molecular Weight Proteinuria in Children with Distal Renal Tubular Acidosis. ( 30110261 )
2018
35
Molecular Diagnosis of Solute Carrier Family 4 Member 1 (SLC4A1) Mutation-Related Autosomal Recessive Distal Renal Tubular Acidosis. ( 30124986 )
2018
36
Renal Tubular Acidosis and the Nephrology Teaching Paradigm. ( 30139457 )
2018
37
Hypokalemic Distal Renal Tubular Acidosis. ( 30139458 )
2018
38
Hyperkalemic Forms of Renal Tubular Acidosis: Clinical and Pathophysiological Aspects. ( 30139459 )
2018
39
Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes. ( 30139460 )
2018
40
Clinical Approach to Proximal Renal Tubular Acidosis in Children. ( 30139461 )
2018
41
Pseudo-Renal Tubular Acidosis: Conditions Mimicking Renal Tubular Acidosis. ( 30139462 )
2018
42
Incomplete Distal Renal Tubular Acidosis and Kidney Stones. ( 30139463 )
2018
43
Distal renal tubular acidosis in sickle cell anemia. ( 30152444 )
2018
44
Oral manifestations of renal tubular acidosis associated with secondary rickets: case report. ( 30199559 )
2018
45
Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children. ( 30230413 )
2018
46
Five Novel Mutations in Chinese Children with Primary Distal Renal Tubular Acidosis. ( 30256676 )
2018
47
Hypokalemic Paralysis Secondary to Renal Tubular Acidosis Revealing Underlying Sjogren's Syndrome. ( 30345187 )
2018
48
Distal renal tubular acidosis secondary to vesico-ureteric reflux: A case report with review of literature. ( 30381529 )
2018
49
Renal Tubular Acidosis and Hypokalemic Paralysis as a First Presentation of Primary Sjögren's Syndrome. ( 30410805 )
2018
50
A Family with Autosomal Dominant Distal Renal Tubular Acidosis Presents with Atypical Phenotype Caused by a Missence Mutation (R388C) of the Human Kidney Anion Exchanger. ( 30554219 )
2018
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Variations for Renal Tubular Acidosis

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Expression for Renal Tubular Acidosis

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Search GEO for disease gene expression data for Renal Tubular Acidosis.
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Pathways for Renal Tubular Acidosis

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Pathways related to Renal Tubular Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 67
Show member pathways
 12.45 ATP6V0A4 ATP6V0D2 ATP6V1B1 SLC12A7 SLC26A1 SLC26A6
2
Insulin receptor recycling 67
Show member pathways
 11.88 ATP6V0A4 ATP6V0D2 ATP6V1B1 CA2 SLC12A7 SLC4A1
3
Phagosome 38
11.76 ATP6V0A4 ATP6V0D2 ATP6V1B1
4
Synaptic vesicle cycle 38
Show member pathways
 11.66 ATP6V0A4 ATP6V0D2 ATP6V1B1
5
Rheumatoid arthritis 38
11.46 ATP6V0A4 ATP6V0D2 ATP6V1B1
6
Bile secretion 38
11.29 CA2 SLC4A4 SLC9A3
7
Proximal tubule bicarbonate reclamation 38
10.69 CA2 SLC4A4 SLC9A3
Sources

GO Terms for Renal Tubular Acidosis

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Cellular components related to Renal Tubular Acidosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 SLC12A7 SLC26A1 SLC26A6 SLC4A1 SLC4A4 SLC4A7
2 endosome GO:0005768 9.81 ATP6V0A4 ATP6V0D2 OCRL WDR72
3 apical part of cell GO:0045177 9.63 ATP6V0A4 CA2 REN
4 phagocytic vesicle membrane GO:0030670 9.58 ATP6V0A4 ATP6V0D2 OCRL
5 brush border membrane GO:0031526 9.54 ATP6V0A4 SLC26A6 SLC9A3
6 proton-transporting V-type ATPase, V0 domain GO:0033179 9.43 ATP6V0A4 ATP6V0D2
7 apical plasma membrane GO:0016324 9.43 ATP6V0A4 ATP6V0D2 ATP6V1B1 SLC26A6 SLC4A7 SLC9A3
8 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.33 ATP6V0A4 ATP6V0D2 ATP6V1B1
9 basolateral plasma membrane GO:0016323 9.17 ATP6V1B1 CA2 SLC26A1 SLC26A6 SLC4A1 SLC4A4
10 membrane GO:0016020 10.07 ATP6V0A4 ATP6V0D2 ATP6V1B1 CA2 OCRL REN
11 plasma membrane GO:0005886 10.06 ATP6V0A4 CA2 OCRL REN SLC12A7 SLC26A1
12 extracellular exosome GO:0070062 10.04 ATP6V0A4 ATP6V0D2 ATP6V1B1 CA2 SLC4A1 SLC4A4

Biological processes related to Renal Tubular Acidosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.91 SLC12A7 SLC26A1 SLC26A6 SLC4A4 SLC4A7 SLC9A3
2 ion transport GO:0006811 9.85 ATP6V0A4 ATP6V0D2 ATP6V1B1 SLC12A7 SLC26A1 SLC26A6
3 sodium ion transport GO:0006814 9.77 SLC4A4 SLC4A7 SLC9A3
4 proton transmembrane transport GO:1902600 9.74 ATP6V0A4 ATP6V1B1 SLC9A3
5 insulin receptor signaling pathway GO:0008286 9.71 ATP6V0A4 ATP6V0D2 ATP6V1B1
6 chloride transport GO:0006821 9.7 SLC26A1 SLC26A6 SLC4A1
7 transferrin transport GO:0033572 9.69 ATP6V0A4 ATP6V0D2 ATP6V1B1
8 ATP hydrolysis coupled proton transport GO:0015991 9.67 ATP6V0A4 ATP6V0D2 ATP6V1B1
9 chloride transmembrane transport GO:1902476 9.67 SLC12A7 SLC26A1 SLC26A6 SLC4A1
10 inorganic anion transport GO:0015698 9.65 SLC4A1 SLC4A4 SLC4A7
11 anion transmembrane transport GO:0098656 9.65 SLC26A1 SLC26A6 SLC4A1 SLC4A4 SLC4A7
12 anion transport GO:0006820 9.62 SLC26A6 SLC4A1 SLC4A4 SLC4A7
13 excretion GO:0007588 9.6 ATP6V0A4 ATP6V1B1
14 sulfate transport GO:0008272 9.58 SLC26A1 SLC26A6
15 sulfate transmembrane transport GO:1902358 9.58 SLC26A1 SLC26A6
16 regulation of pH GO:0006885 9.58 ATP6V0A4 ATP6V1B1 SLC9A3
17 vacuolar acidification GO:0007035 9.56 ATP6V0A4 ATP6V0D2
18 oxalate transport GO:0019532 9.55 SLC26A1 SLC26A6
19 positive regulation of dipeptide transmembrane transport GO:2001150 9.46 CA2 SLC26A6
20 bicarbonate transport GO:0015701 9.43 CA2 SLC26A1 SLC26A6 SLC4A1 SLC4A4 SLC4A7
21 regulation of intracellular pH GO:0051453 9.1 CA2 SLC26A6 SLC4A1 SLC4A4 SLC4A7 SLC9A3

Molecular functions related to Renal Tubular Acidosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 symporter activity GO:0015293 9.67 SLC12A7 SLC4A4 SLC4A7
2 antiporter activity GO:0015297 9.58 SLC26A1 SLC26A6 SLC9A3
3 proton transmembrane transporter activity GO:0015078 9.54 ATP6V0A4 ATP6V0D2 ATP6V1B1
4 proton-transporting ATPase activity, rotational mechanism GO:0046961 9.52 ATP6V0A4 ATP6V0D2
5 sulfate transmembrane transporter activity GO:0015116 9.51 SLC26A1 SLC26A6
6 anion:anion antiporter activity GO:0015301 9.5 SLC26A1 SLC26A6 SLC4A1
7 secondary active sulfate transmembrane transporter activity GO:0008271 9.48 SLC26A1 SLC26A6
8 oxalate transmembrane transporter activity GO:0019531 9.46 SLC26A1 SLC26A6
9 sodium:bicarbonate symporter activity GO:0008510 9.43 SLC4A4 SLC4A7
10 bicarbonate transmembrane transporter activity GO:0015106 9.43 SLC26A1 SLC26A6 SLC4A1
11 chloride transmembrane transporter activity GO:0015108 9.33 SLC26A1 SLC26A6 SLC4A1
12 anion transmembrane transporter activity GO:0008509 9.26 SLC26A6 SLC4A1 SLC4A4 SLC4A7
13 inorganic anion exchanger activity GO:0005452 8.92 SLC26A6 SLC4A1 SLC4A4 SLC4A7
Sources

Sources for Renal Tubular Acidosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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