MCID: RNL005
MIFTS: 20

Renal Wilms' Tumor

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Renal Wilms' Tumor

MalaCards integrated aliases for Renal Wilms' Tumor:

Name: Renal Wilms' Tumor 12 15
Nonanaplastic Renal Wilm's Tumor 12
Nonanaplastic Renal Wilms Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5176
NCIt 50 C6951
UMLS 72 C1335062

Summaries for Renal Wilms' Tumor

MalaCards based summary : Renal Wilms' Tumor, also known as nonanaplastic renal wilm's tumor, is related to wilms tumor 5 and mixed cell type kidney wilms' tumor. An important gene associated with Renal Wilms' Tumor is WT1 (WT1 Transcription Factor), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include kidney, cervix and testis, and related phenotype is neoplasm.

Related Diseases for Renal Wilms' Tumor

Diseases related to Renal Wilms' Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 wilms tumor 5 11.7
2 mixed cell type kidney wilms' tumor 11.4
3 blastema predominant kidney wilms' tumor 11.4
4 epithelial predominant wilms' tumor 11.4
5 stromal predominant kidney wilms' tumor 11.4
6 end stage renal failure 9.5 WT1 IL6
7 urinary system disease 9.5 WT1 IL6
8 ewing sarcoma 9.5 WT1 IL6
9 sarcoma 9.4 WT1 IL6
10 kidney disease 9.2 WT1 IL6

Graphical network of the top 20 diseases related to Renal Wilms' Tumor:



Diseases related to Renal Wilms' Tumor

Symptoms & Phenotypes for Renal Wilms' Tumor

MGI Mouse Phenotypes related to Renal Wilms' Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 IL6 WT1

Drugs & Therapeutics for Renal Wilms' Tumor

Search Clinical Trials , NIH Clinical Center for Renal Wilms' Tumor

Genetic Tests for Renal Wilms' Tumor

Anatomical Context for Renal Wilms' Tumor

MalaCards organs/tissues related to Renal Wilms' Tumor:

41
Kidney, Cervix, Testis

Publications for Renal Wilms' Tumor

Articles related to Renal Wilms' Tumor:

(show all 13)
# Title Authors PMID Year
1
A Case of Primary Paratesticular Wilms Tumor in an Undescended Testis. 38
30610907 2019
2
Primary Extra-renal Wilms' Tumor in Urinary Bladder: Rare Presentation of a Common Pediatric Malignancy. 38
31142414 2019
3
Wilms' tumor and benign renal tumor combined with hypospadias and incomplete orchiocatabasis appearing simultaneously in a 10 months old boy. 38
31134609 2019
4
Extra-Renal Wilms' Tumor: A Rare Diagnosis. 38
26064807 2015
5
Urinary exosomal Wilms' tumor-1 as a potential biomarker for podocyte injury. 38
23761678 2013
6
Wilms' tumor of the cervix: a case report and review of the literature. 38
10620450 2000
7
Quantitative analysis of ultrasonic B-mode images. 38
10604798 1999
8
Brachytherapy for residual intra-renal Wilms' tumor. 38
9078328 1997
9
Interleukin-6 production in primary histoculture by normal human kidney and renal tumor tissues. 38
9066639 1997
10
Extrarenal Wilms' tumor: an ultrastructural and immunoelectron microscopic case report. 38
8882361 1996
11
Extrarenal Wilms' tumors. A study of their relationship with classical renal Wilms' tumor using expression of WT1 as a molecular marker. 38
8388523 1993
12
Extrarenal Wilms' tumor: staging, treatment, and prognosis. 38
1845874 1991
13
Extrarenal Wilms' tumor: an analysis of four cases. 38
2544508 1989

Variations for Renal Wilms' Tumor

Expression for Renal Wilms' Tumor

Search GEO for disease gene expression data for Renal Wilms' Tumor.

Pathways for Renal Wilms' Tumor

Pathways related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 WT1 IL6
2 10.75 WT1 IL6

GO Terms for Renal Wilms' Tumor

Biological processes related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.26 WT1 IL6
2 negative regulation of apoptotic process GO:0043066 9.16 WT1 IL6
3 negative regulation of cell proliferation GO:0008285 8.96 WT1 IL6
4 positive regulation of gene expression GO:0010628 8.62 WT1 IL6

Sources for Renal Wilms' Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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