MCID: RNL005
MIFTS: 28

Renal Wilms' Tumor

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Renal Wilms' Tumor

MalaCards integrated aliases for Renal Wilms' Tumor:

Name: Renal Wilms' Tumor 12 15
Nonanaplastic Renal Wilm's Tumor 12
Nonanaplastic Renal Wilms Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5176
NCIt 49 C6951
UMLS 71 C1335062

Summaries for Renal Wilms' Tumor

MalaCards based summary : Renal Wilms' Tumor, also known as nonanaplastic renal wilm's tumor, is related to wilms tumor 5 and mixed cell type kidney wilms' tumor. An important gene associated with Renal Wilms' Tumor is PSMA5 (Proteasome 20S Subunit Alpha 5), and among its related pathways/superpathways are Gene Expression and Cell Cycle, Mitotic. Affiliated tissues include kidney, testis and cervix, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Renal Wilms' Tumor

Diseases related to Renal Wilms' Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 wilms tumor 5 11.7
2 mixed cell type kidney wilms' tumor 11.4
3 blastema predominant kidney wilms' tumor 11.4
4 epithelial predominant wilms' tumor 11.4
5 stromal predominant kidney wilms' tumor 11.4
6 cystic fibrosis 8.8 PSMA6 PSMA5 PSMA3 PSMA1

Graphical network of the top 20 diseases related to Renal Wilms' Tumor:



Diseases related to Renal Wilms' Tumor

Symptoms & Phenotypes for Renal Wilms' Tumor

GenomeRNAi Phenotypes related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 10.34 PRMT1 PSMA1 PSMA6 SMYD3
2 Decreased shRNA abundance GR00251-A-2 10.34 PRMT1 PSMA1 PSMA6 SMYD3
3 Decreased viability GR00106-A-0 10.18 PSMA1
4 Decreased viability GR00240-S-1 10.18 PSMA1 PSMA3 PSMA5 PSMA6
5 Decreased viability GR00381-A-1 10.18 PSMA3 PSMA5 PSMA6
6 Decreased viability GR00402-S-2 10.18 PSMA1 PSMA3 PSMA5 PSMA6
7 FOXO1 nuclear localization GR00247-A-1 10.1 PSMA3 PSMA5 PSMA6
8 FOXO1 nuclear localization GR00247-A-2 10.1 PSMA3 PSMA5 PSMA6
9 Decreased HIV-1 infection GR00226-A 9.67 PSMA1 PSMA3 PSMA5
10 G0/1 arrest GR00098-A-2 9.56 PSMA1 PSMA3 PSMA5 PSMA6
11 Decreased Salmonella enterica Typhimurium effector injection GR00133-A-4 9.48 PSMA1 PSMA3
12 Decreased Salmonella enterica Typhimurium ruffling GR00133-A-5 9.46 PSMA1 PSMA3
13 Increased G2M DNA content, increased 8N DNA content GR00098-A-1 9.43 PRMT1 PRMT5 PSMA1 PSMA3 PSMA5 PSMA6
14 Downregulation of NFkappaB pathway GR00313-A 9.37 PSMA5 PSMA6
15 HIV Rev nuclear localization GR00247-A-3 9.16 PSMA5 PSMA6
16 Reduced mammosphere formation GR00396-S 9.02 PRMT5 PSMA1 PSMA3 PSMA5 PSMA6

Drugs & Therapeutics for Renal Wilms' Tumor

Search Clinical Trials , NIH Clinical Center for Renal Wilms' Tumor

Genetic Tests for Renal Wilms' Tumor

Anatomical Context for Renal Wilms' Tumor

MalaCards organs/tissues related to Renal Wilms' Tumor:

40
Kidney, Testis, Cervix

Publications for Renal Wilms' Tumor

Articles related to Renal Wilms' Tumor:

(show all 13)
# Title Authors PMID Year
1
A Case of Primary Paratesticular Wilms Tumor in an Undescended Testis. 61
30610907 2019
2
Primary Extra-renal Wilms' Tumor in Urinary Bladder: Rare Presentation of a Common Pediatric Malignancy. 61
31142414 2019
3
Wilms' tumor and benign renal tumor combined with hypospadias and incomplete orchiocatabasis appearing simultaneously in a 10 months old boy. 61
31134609 2019
4
Extra-Renal Wilms' Tumor: A Rare Diagnosis. 61
26064807 2015
5
Urinary exosomal Wilms' tumor-1 as a potential biomarker for podocyte injury. 61
23761678 2013
6
Wilms' tumor of the cervix: a case report and review of the literature. 61
10620450 2000
7
Quantitative analysis of ultrasonic B-mode images. 61
10604798 1999
8
Brachytherapy for residual intra-renal Wilms' tumor. 61
9078328 1997
9
Interleukin-6 production in primary histoculture by normal human kidney and renal tumor tissues. 61
9066639 1997
10
Extrarenal Wilms' tumor: an ultrastructural and immunoelectron microscopic case report. 61
8882361 1996
11
Extrarenal Wilms' tumors. A study of their relationship with classical renal Wilms' tumor using expression of WT1 as a molecular marker. 61
8388523 1993
12
Extrarenal Wilms' tumor: staging, treatment, and prognosis. 61
1845874 1991
13
Extrarenal Wilms' tumor: an analysis of four cases. 61
2544508 1989

Variations for Renal Wilms' Tumor

Expression for Renal Wilms' Tumor

Search GEO for disease gene expression data for Renal Wilms' Tumor.

Pathways for Renal Wilms' Tumor

Pathways related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 PSMA6 PSMA5 PSMA3 PSMA1 PRMT5 PRMT1
2
Show member pathways
13.1 PSMA6 PSMA5 PSMA3 PSMA1
3
Show member pathways
13.07 PSMA6 PSMA5 PSMA3 PSMA1
4
Show member pathways
13.04 PSMA6 PSMA5 PSMA3 PSMA1
5
Show member pathways
12.98 PSMA6 PSMA5 PSMA3 PSMA1
6
Show member pathways
12.91 PSMA6 PSMA5 PSMA3 PSMA1
7
Show member pathways
12.87 PSMA6 PSMA5 PSMA3 PSMA1
8
Show member pathways
12.8 PSMA6 PSMA5 PSMA3 PSMA1
9
Show member pathways
12.75 PSMA6 PSMA5 PSMA3 PSMA1
10
Show member pathways
12.74 PSMA6 PSMA5 PSMA3 PSMA1 PRMT1
11
Show member pathways
12.65 PSMA6 PSMA5 PSMA3 PSMA1
12
Show member pathways
12.6 PSMA6 PSMA5 PSMA3 PSMA1
13
Show member pathways
12.59 PSMA6 PSMA5 PSMA3 PSMA1
14
Show member pathways
12.56 PSMA6 PSMA5 PSMA3 PSMA1
15
Show member pathways
12.48 PSMA6 PSMA5 PSMA3 PSMA1
16
Show member pathways
12.46 PSMA6 PSMA5 PSMA3 PSMA1
17
Show member pathways
12.4 PSMA6 PSMA5 PSMA3 PSMA1
18
Show member pathways
12.35 PSMA6 PSMA5 PSMA3 PSMA1
19
Show member pathways
12.31 PSMA6 PSMA5 PSMA3 PSMA1
20
Show member pathways
12.2 PSMA6 PSMA5 PSMA3 PSMA1
21 12.19 SMYD3 PRMT5 PRMT1
22 12.13 PSMA6 PSMA5 PSMA3 PSMA1
23
Show member pathways
12.12 PSMA6 PSMA5 PSMA3 PSMA1
24
Show member pathways
12.02 PSMA6 PSMA5 PSMA3 PSMA1
25
Show member pathways
11.9 PSMA6 PSMA5 PSMA3 PSMA1
26 11.61 PSMA6 PSMA5 PSMA3 PSMA1
27 11.35 PSMA6 PSMA5 PSMA3 PSMA1
28 11.29 PSMA6 PSMA5 PSMA3 PSMA1
29
Show member pathways
10.92 PSMA6 PSMA5 PSMA3 PSMA1

GO Terms for Renal Wilms' Tumor

Cellular components related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10 SMYD3 PSMA6 PSMA5 PSMA3 PSMA1 PRMT5
2 cytoplasm GO:0005737 9.98 SMYD3 PSMA6 PSMA5 PSMA3 PSMA1 PRMT5
3 cytosol GO:0005829 9.91 SMYD3 PSMA6 PSMA5 PSMA3 PSMA1 PRMT5
4 nucleoplasm GO:0005654 9.8 SMYD3 PSMA6 PSMA5 PSMA3 PSMA1 PRMT5
5 proteasome complex GO:0000502 9.46 PSMA6 PSMA5 PSMA3 PSMA1
6 polysome GO:0005844 9.4 PSMA6 PSMA1
7 methylosome GO:0034709 9.32 PRMT5 PRMT1
8 proteasome core complex GO:0005839 9.26 PSMA6 PSMA5 PSMA3 PSMA1
9 proteasome core complex, alpha-subunit complex GO:0019773 8.92 PSMA6 PSMA5 PSMA3 PSMA1

Biological processes related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.96 PSMA6 PSMA5 PSMA3 PSMA1
2 transmembrane transport GO:0055085 9.95 PSMA6 PSMA5 PSMA3 PSMA1
3 post-translational protein modification GO:0043687 9.94 PSMA6 PSMA5 PSMA3 PSMA1
4 ubiquitin-dependent protein catabolic process GO:0006511 9.93 PSMA6 PSMA5 PSMA3 PSMA1
5 protein deubiquitination GO:0016579 9.92 PSMA6 PSMA5 PSMA3 PSMA1
6 MAPK cascade GO:0000165 9.92 PSMA6 PSMA5 PSMA3 PSMA1
7 protein polyubiquitination GO:0000209 9.91 PSMA6 PSMA5 PSMA3 PSMA1
8 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 9.91 PSMA6 PSMA5 PSMA3 PSMA1
9 negative regulation of canonical Wnt signaling pathway GO:0090090 9.9 PSMA6 PSMA5 PSMA3 PSMA1
10 T cell receptor signaling pathway GO:0050852 9.89 PSMA6 PSMA5 PSMA3 PSMA1
11 Fc-epsilon receptor signaling pathway GO:0038095 9.88 PSMA6 PSMA5 PSMA3 PSMA1
12 positive regulation of canonical Wnt signaling pathway GO:0090263 9.88 PSMA6 PSMA5 PSMA3 PSMA1
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.87 PSMA6 PSMA5 PSMA3 PSMA1
14 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.86 PSMA6 PSMA5 PSMA3 PSMA1
15 regulation of mRNA stability GO:0043488 9.85 PSMA6 PSMA5 PSMA3 PSMA1
16 interleukin-1-mediated signaling pathway GO:0070498 9.84 PSMA6 PSMA5 PSMA3 PSMA1
17 methylation GO:0032259 9.83 SMYD3 PRMT5 PRMT1
18 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 9.83 PSMA6 PSMA5 PSMA3 PSMA1
19 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.81 PSMA6 PSMA5 PSMA3 PSMA1
20 anaphase-promoting complex-dependent catabolic process GO:0031145 9.8 PSMA6 PSMA5 PSMA3 PSMA1
21 regulation of mitotic cell cycle phase transition GO:1901990 9.78 PSMA6 PSMA5 PSMA3 PSMA1
22 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.76 PSMA6 PSMA5 PSMA3 PSMA1
23 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.73 PSMA6 PSMA5 PSMA3 PSMA1
24 NIK/NF-kappaB signaling GO:0038061 9.71 PSMA6 PSMA5 PSMA3 PSMA1
25 regulation of hematopoietic stem cell differentiation GO:1902036 9.67 PSMA6 PSMA5 PSMA3 PSMA1
26 protein methylation GO:0006479 9.66 PRMT5 PRMT1
27 peptidyl-arginine N-methylation GO:0035246 9.65 PRMT5 PRMT1
28 histone H4-R3 methylation GO:0043985 9.64 PRMT5 PRMT1
29 peptidyl-arginine methylation GO:0018216 9.63 PRMT5 PRMT1
30 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.62 PSMA6 PSMA5 PSMA3 PSMA1
31 proteolysis involved in cellular protein catabolic process GO:0051603 9.56 PSMA6 PSMA5 PSMA3 PSMA1
32 regulation of cellular amino acid metabolic process GO:0006521 9.46 PSMA6 PSMA5 PSMA3 PSMA1
33 proteasomal protein catabolic process GO:0010498 9.26 PSMA6 PSMA5 PSMA3 PSMA1
34 proteasomal ubiquitin-independent protein catabolic process GO:0010499 8.92 PSMA6 PSMA5 PSMA3 PSMA1

Molecular functions related to Renal Wilms' Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 PSMA6 PSMA5 PSMA3 PSMA1
2 methyltransferase activity GO:0008168 9.54 SMYD3 PRMT5 PRMT1
3 methyl-CpG binding GO:0008327 9.4 PRMT5 PRMT1
4 protein-arginine N-methyltransferase activity GO:0016274 9.26 PRMT5 PRMT1
5 endopeptidase activity GO:0004175 9.26 PSMA6 PSMA5 PSMA3 PSMA1
6 histone methyltransferase activity (H4-R3 specific) GO:0044020 9.16 PRMT5 PRMT1
7 threonine-type endopeptidase activity GO:0004298 8.92 PSMA6 PSMA5 PSMA3 PSMA1

Sources for Renal Wilms' Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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