MCID: RNV001
MIFTS: 50

Renovascular Hypertension

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renovascular Hypertension

MalaCards integrated aliases for Renovascular Hypertension:

Name: Renovascular Hypertension 12 6 15
Hypertension, Renovascular 44 73
Hypertension Renovascular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1591
ICD10 33 I15.0
MeSH 44 D006978
NCIt 50 C85044
UMLS 73 C0020545

Summaries for Renovascular Hypertension

MalaCards based summary : Renovascular Hypertension, also known as hypertension, renovascular, is related to malignant renovascular hypertension and nephrosclerosis. An important gene associated with Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Calcium signaling pathway and Fluid shear stress and atherosclerosis. The drugs Anticholesteremic Agents and Angiotensin Receptor Antagonists have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Renovascular hypertension (or "renal hypertension") is a condition in which high blood pressure is... more...

Related Diseases for Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 malignant renovascular hypertension 34.0 EDN1 REN
2 nephrosclerosis 32.1 ACE AGTR1
3 renal hypertension 31.8 ACE ADM AGTR1 EDN1 REN
4 fibromuscular dysplasia 30.7 ACE AGTR1 REN
5 hypertensive retinopathy 30.5 ACE REN
6 hypertension, diastolic 30.1 ACE REN
7 ischemia 30.1 ACE EDN1 HMOX1 NOS1 NOS3
8 renal tuberculosis 30.0 EDN1 REN
9 renal artery disease 29.7 ACE AGTR1 NOS3 REN
10 aortic coarctation 29.7 ACE AGTR1 EDN1 NOS3
11 arteries, anomalies of 29.7 ACE AGTR1 EDN1 NOS3 REN
12 arteriosclerosis 29.6 ACE ADM EDN1 HMOX1
13 coronary heart disease 1 29.5 ACE AGTR1 EDN1 NOS3
14 hypertension, essential 29.4 ACE ADM AGTR1 EDN1 NOS3 NPPA
15 pulmonary edema 29.4 ACE EDN1 HMOX1 NOS3 NPPA REN
16 congestive heart failure 29.3 ACE ADM AGTR1 EDN1 NPPA REN
17 diabetes mellitus 29.2 ACE AGTR1 CAT EDN1 NOS3 REN
18 vascular disease 29.2 ACE CAT EDN1 HMOX1 NOS3 REN
19 chronic kidney failure 29.2 ACE AGTR1 EDN1 NOS3 NPPA REN
20 heart disease 28.9 ACE ADM AGTR1 EDN1 NOS3 NPPA
21 kidney disease 28.8 ACE ADM AGTR1 EDN1 HMOX1 NOS3
22 benign renovascular hypertension 12.3
23 takayasu arteritis 10.4
24 moyamoya disease 1 10.3
25 aortitis 10.3
26 hyporeninemic hypoaldosteronism 10.2 ACE REN
27 renal artery obstruction 10.2 ACE REN
28 arteritic anterior ischemic optic neuropathy 10.2 ACE NOS3
29 hypertensive encephalopathy 10.2 ACE REN
30 postural hypotension 10.2 NPPA REN
31 malignant hypertensive renal disease 10.2 EDN1 REN
32 orthostatic proteinuria 10.2 ACE REN
33 malignant secondary hypertension 10.2 EDN1 REN
34 perinephritis 10.2 EDN1 REN
35 thrombosis 10.2
36 anterolateral myocardial infarction 10.2 ACE NPPA
37 malignant essential hypertension 10.2 ACE REN
38 syndrome of inappropriate antidiuretic hormone 10.2 ACE NPPA
39 acute poststreptococcal glomerulonephritis 10.2 EDN1 NPPA
40 central sleep apnea 10.2 NOS3 NPPA
41 coronary artery vasospasm 10.2 EDN1 NOS3
42 chronic mountain sickness 10.2 EDN1 NOS3
43 nephrotic syndrome 10.2
44 encephalopathy 10.2
45 brachydactyly, type e2 10.2 EDN1 NOS3
46 ischemic heart disease 10.1 ACE NOS3
47 mitral valve insufficiency 10.1 ACE NPPA
48 hypoaldosteronism 10.1 ACE NPPA REN
49 pure autonomic failure 10.1 ACE NPPA REN
50 heart valve disease 10.1 ACE NPPA REN

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to Renovascular Hypertension

Symptoms & Phenotypes for Renovascular Hypertension

MGI Mouse Phenotypes related to Renovascular Hypertension:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ACE ADM AGTR1 EDN1 HMOX1 NF1
2 homeostasis/metabolism MP:0005376 10.14 ACE ADM AGTR1 CAT EDN1 HMOX1
3 behavior/neurological MP:0005386 10.11 ACE ADM AGTR1 HMOX1 NF1 NOS1
4 hematopoietic system MP:0005397 10.09 ACE ADM AGTR1 HMOX1 NF1 NOS1
5 growth/size/body region MP:0005378 10.06 ACE AGTR1 EDN1 HMOX1 NF1 NOS1
6 endocrine/exocrine gland MP:0005379 10.02 ACE ADM EDN1 HMOX1 NF1 NOS1
7 immune system MP:0005387 9.97 ACE ADM AGTR1 HMOX1 NF1 NOS1
8 mortality/aging MP:0010768 9.96 ACE ADM AGTR1 CAT EDN1 HMOX1
9 adipose tissue MP:0005375 9.92 ACE AGTR1 HMOX1 NOS1 NOS3
10 liver/biliary system MP:0005370 9.8 ACE ADM HMOX1 NF1 NOS1 NOS3
11 muscle MP:0005369 9.76 ADM EDN1 HMOX1 NF1 NOS1 NOS3
12 renal/urinary system MP:0005367 9.65 ACE ADM AGTR1 EDN1 HMOX1 NF1
13 reproductive system MP:0005389 9.1 ACE ADM HMOX1 NOS1 NOS3 REN

Drugs & Therapeutics for Renovascular Hypertension

Drugs for Renovascular Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticholesteremic Agents
2 Angiotensin Receptor Antagonists
3 Antihypertensive Agents
4 Angiotensin-Converting Enzyme Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
2 MSC for Occlusive Disease of the Kidney Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
3 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
4 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Active, not recruiting NCT02266394 Phase 1 Mesenchymal stem cell
5 Magnetic Resonance Imaging for Evaluating Kidney Function Completed NCT00006173
6 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
7 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable
8 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
9 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Active, not recruiting NCT01673373 Not Applicable

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypertension, renovascular

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

MalaCards organs/tissues related to Renovascular Hypertension:

41
Kidney, Testes, Endothelial, Heart, Liver, Brain, Smooth Muscle

Publications for Renovascular Hypertension

Articles related to Renovascular Hypertension:

(show top 50) (show all 1045)
# Title Authors Year
1
Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension. ( 29331564 )
2018
2
Renovascular hypertension: endovascular therapy in complicated aortic Stanford type B dissection. ( 29850408 )
2018
3
Borderline bilateral renal artery stenosis assessed with high-resolution angiography, intravascular ultrasound, and renal fractional flow reserve in a patient with renovascular hypertension. ( 29756199 )
2018
4
Possible interesting link between Janus kinase 2 mutation and renovascular hypertension. ( 29656557 )
2018
5
Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. ( 29656438 )
2018
6
Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension. ( 29842964 )
2018
7
Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection. ( 29590257 )
2018
8
Direct Recording of Cardiac and Renal Sympathetic Nerve Activity Shows Differential Control in Renovascular Hypertension. ( 29686011 )
2018
9
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension. ( 29425960 )
2018
10
Current Concepts in the Treatment of Renovascular Hypertension. ( 28985335 )
2018
11
Renovascular hypertension in small children-is it Takayasu arteritis or fibromuscular dysplasia? ( 29861130 )
2018
12
Chronic intermittent hypoxia and renovascular hypertension: A case of one plus one equals one-half! ( 29377392 )
2018
13
Neonatal renovascular hypertension. ( 29878627 )
2018
14
Is there still a role for renal artery stenting in the management of renovascular hypertension - A single-center experience and where do we stand in 2018? ( 29934065 )
2018
15
Fibromuscular Dysplasia: Another Paradigm Shift in Renovascular Hypertension? ( 29709956 )
2018
16
Correction to: Comments on Chavent et al.: Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 29404688 )
2018
17
A Unique Case of Renovascular Hypertension due to Fibromuscular Dysplasia in an Extra-renal Artery. ( 29709926 )
2018
18
Atrial secretion of ANP is suppressed in renovascular hypertension: shifting of ANP secretion from atria to the left ventricle. ( 29979625 )
2018
19
Interventions in children with renovascular hypertension: A 27-year retrospective single-center experience. ( 29635838 )
2018
20
Renal resistive index for renovascular hypertension: In the quest of the Holy Grail. ( 29450962 )
2018
21
Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension. ( 29872089 )
2018
22
A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus. ( 30443000 )
2018
23
Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension. ( 30289595 )
2018
24
Takayasu Arteritis Presenting as Renovascular Hypertension and Renal Failure in a Patient with Factor VII Deficiency. ( 30515046 )
2018
25
Orthotopic renal autotransplantation for young-onset and medical treatment-requiring complex renovascular hypertension. ( 30129810 )
2018
26
Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats. ( 30170073 )
2018
27
The Rise and Decline of Diagnostic Angiography for Renovascular Hypertension: A Memoir. ( 30274860 )
2018
28
In renovascular hypertension, TNF-α type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure. ( 30358805 )
2018
29
An infant case of renovascular hypertension in moyamoya disease treated by angioplasty. ( 30511550 )
2018
30
ACR Appropriateness Criteria<sup>Ar</sup>Renovascular Hypertension. ( 29101991 )
2017
31
Sonographic evaluation of renovascular hypertension in the pediatric population: State-of-the-art. ( 28370243 )
2017
32
Lotus Root Sign in the Renal Artery in Renovascular Hypertension. ( 28250287 )
2017
33
Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension. ( 28622281 )
2017
34
Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT<sub>1</sub>R-NADPH oxidase pathway. ( 29274384 )
2017
35
Treatment outcomes according to underlying disease in pediatric renovascular hypertension. ( 29281158 )
2017
36
New Insights Into Pathophysiology, Diagnosis, and Treatment of Renovascular Hypertension. ( 28270639 )
2017
37
Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes. ( 28347166 )
2017
38
Successful long-term effects of direct renin inhibitor aliskiren in a patient with atherosclerotic renovascular hypertension. ( 28509129 )
2017
39
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. ( 28275232 )
2017
40
Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of<i>Acanthospermum hispidum</i>DC. on Ovariectomized Rats with Renovascular Hypertension. ( 29234376 )
2017
41
Complex glomerular pathology of thrombotic microangiopathy and focal segmental glomerulosclerosis forms tumor-like mass in a renal transplant donor with severe renovascular hypertension. ( 28509120 )
2017
42
Unenhanced renal magnetic resonance angiography in patients with chronic kidney disease &amp;amp; suspected renovascular hypertension: Can it affect patient management? ( 29578191 )
2017
43
Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension. ( 28315847 )
2017
44
Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. ( 29073282 )
2017
45
Revisiting angioplasty for renovascular hypertension. ( 28852488 )
2017
46
Transplantation of bone marrow-derived MSCs improves renal function and Na(+)+K(+)-ATPase activity in rats with renovascular hypertension. ( 28374150 )
2017
47
Comments on Chavent et al.: Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28695307 )
2017
48
Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension. ( 28945940 )
2017
49
Treatment of severe hypertension in a 14-year-old child: Successful blood pressure control with additive administration of captopril, an angiotensin-converting enzyme inhibitor, in a patient with bilateral renovascular hypertension. ( 28621587 )
2017
50
Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28429121 )
2017

Variations for Renovascular Hypertension

ClinVar genetic disease variations for Renovascular Hypertension:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PKD1 NM_000296.3(PKD1): c.9185T> A (p.Val3062Asp) single nucleotide variant Likely pathogenic rs1057518856 GRCh37 Chromosome 16, 2152398: 2152398
2 PKD1 NM_000296.3(PKD1): c.9185T> A (p.Val3062Asp) single nucleotide variant Likely pathogenic rs1057518856 GRCh38 Chromosome 16, 2102397: 2102397

Expression for Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for Renovascular Hypertension

Pathways related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 AGTR1 NOS1 NOS3
2 11.81 EDN1 HMOX1 NOS3
3 11.79 AGTR1 NOS1 NOS3
4 11.6 AGTR1 EDN1 NOS3
5 11.53 HMOX1 NOS3 REN
6 11.31 ADM EDN1 HMOX1
7 11.26 EDN1 HMOX1 NOS3 NPPA
8 11.25 ACE AGTR1 REN
9
Show member pathways
11.21 NOS1 NOS3
10 11.11 EDN1 NOS3
11 11.1 HMOX1 NOS3
12 11.05 CAT HMOX1
13 10.99 NOS1 NOS3
14
Show member pathways
10.94 NOS1 NOS3
15
Show member pathways
10.93 CAT NOS1 NOS3
16 10.89 NOS1 NOS3
17
Show member pathways
10.83 ACE AGTR1 NOS3 REN
18 10.57 NOS1 NOS3
19 10.27 NOS1 NOS3

GO Terms for Renovascular Hypertension

Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACE ADM CAT EDN1 HMOX1 NPPA
2 vesicle membrane GO:0012506 9.16 NOS1 NOS3
3 caveola GO:0005901 9.13 HMOX1 NOS1 NOS3

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 ADM HMOX1 NF1 NOS3
2 heart development GO:0007507 9.85 ADM EDN1 NF1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.82 ADM AGTR1 EDN1
4 positive regulation of angiogenesis GO:0045766 9.81 ADM HMOX1 NOS3
5 kidney development GO:0001822 9.71 ACE AGTR1 CAT REN
6 response to insulin GO:0032868 9.7 ADM CAT NPPA
7 response to nicotine GO:0035094 9.68 EDN1 HMOX1
8 regulation of cardiac conduction GO:1903779 9.68 NOS1 NPPA
9 regulation of angiogenesis GO:0045765 9.68 HMOX1 NF1
10 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.67 HMOX1 NOS3
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.67 EDN1 NF1
12 blood vessel remodeling GO:0001974 9.67 ACE NOS3
13 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.66 AGTR1 EDN1
14 negative regulation of blood pressure GO:0045776 9.66 NOS1 NOS3
15 positive regulation of blood vessel diameter GO:0097755 9.65 ADM HMOX1
16 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.65 AGTR1 HMOX1
17 vasodilation GO:0042311 9.64 NOS1 NOS3
18 regulation of sodium ion transport GO:0002028 9.63 NOS1 NOS3
19 nitric oxide mediated signal transduction GO:0007263 9.63 NOS1 NOS3
20 response to muscle stretch GO:0035994 9.62 EDN1 NPPA
21 amyloid-beta metabolic process GO:0050435 9.61 ACE REN
22 negative regulation of calcium ion transport GO:0051926 9.61 NOS1 NOS3
23 regulation of blood vessel diameter GO:0097746 9.6 ACE AGTR1
24 nitric oxide biosynthetic process GO:0006809 9.59 NOS1 NOS3
25 angiotensin maturation GO:0002003 9.58 ACE REN
26 negative regulation of potassium ion transport GO:0043267 9.58 NOS1 NOS3
27 positive regulation of guanylate cyclase activity GO:0031284 9.57 NOS1 NOS3
28 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 9.56 NOS1 NPPA
29 arginine catabolic process GO:0006527 9.55 NOS1 NOS3
30 response to lipopolysaccharide GO:0032496 9.55 ADM EDN1 NOS1 NOS3 REN
31 negative regulation of hydrolase activity GO:0051346 9.54 NOS1 NOS3
32 regulation of vasoconstriction GO:0019229 9.54 ACE AGTR1 EDN1
33 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.51 EDN1 NOS3
34 positive regulation of heart rate GO:0010460 9.5 ADM EDN1 NPPA
35 response to hypoxia GO:0001666 9.5 ADM CAT EDN1 HMOX1 NF1 NOS1
36 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.49 ACE AGTR1
37 response to ozone GO:0010193 9.48 CAT EDN1
38 renin-angiotensin regulation of aldosterone production GO:0002018 9.46 AGTR1 REN
39 smooth muscle hyperplasia GO:0014806 9.43 HMOX1 NOS3
40 regulation of blood vessel size GO:0050880 9.43 EDN1 NOS3 NPPA
41 regulation of blood pressure GO:0008217 9.1 ACE EDN1 HMOX1 NOS3 NPPA REN

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.81 CAT HMOX1 NOS1 NOS3
2 hormone activity GO:0005179 9.65 ADM EDN1 NPPA
3 signaling receptor binding GO:0005102 9.55 ADM CAT EDN1 NPPA REN
4 FMN binding GO:0010181 9.49 NOS1 NOS3
5 arginine binding GO:0034618 9.46 NOS1 NOS3
6 NADPH-hemoprotein reductase activity GO:0003958 9.43 NOS1 NOS3
7 NADP binding GO:0050661 9.43 CAT NOS1 NOS3
8 cadmium ion binding GO:0046870 9.4 NOS1 NOS3
9 tetrahydrobiopterin binding GO:0034617 9.37 NOS1 NOS3
10 nitric-oxide synthase activity GO:0004517 9.32 NOS1 NOS3
11 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
12 heme binding GO:0020037 8.92 CAT HMOX1 NOS1 NOS3

Sources for Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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