MCID: RNV001
MIFTS: 47

Renovascular Hypertension

Categories: Cancer diseases, Cardiovascular diseases, Nephrological diseases
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Aliases & Classifications for Renovascular Hypertension

MalaCards integrated aliases for Renovascular Hypertension:

Name: Renovascular Hypertension 11 5 14 16 75 31
Hypertension, Renovascular 43 71
Hypertension Renovascular 53

Classifications:



External Ids:

Disease Ontology 11 DOID:1591
MeSH 43 D006978
NCIt 49 C85044
SNOMED-CT 68 123799005
ICD10 31 I15.0
UMLS 71 C0020545

Summaries for Renovascular Hypertension

MalaCards based summary: Renovascular Hypertension, also known as hypertension, renovascular, is related to malignant renovascular hypertension and nephrosclerosis. An important gene associated with Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Antihypertensive Agents and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone marrow and smooth muscle, and related phenotypes are renal/urinary system and homeostasis/metabolism

Wikipedia: 75 Renovascular hypertension is a condition in which high blood pressure is caused by the kidneys' hormonal... more...

Related Diseases for Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 435)
# Related Disease Score Top Affiliating Genes
1 malignant renovascular hypertension 32.6 REN EDN1 AGTR1
2 nephrosclerosis 32.1 NR3C2 AGTR1 ACE
3 renal artery atheroma 31.8 REN ALB AGTR1 ACE
4 fibromuscular dysplasia 31.7 REN AGTR1 AGT ACE
5 renal artery obstruction 30.9 REN ACE
6 hypertension, diastolic 30.9 REN ACE
7 malignant hypertension 30.8 REN NPPB NPPA AGTR1 ADM ACE
8 hypokalemia 30.7 REN NR3C2 ALB ACE
9 renal artery disease 30.7 REN NOS3 ALB AGT ACE
10 pyelonephritis 30.6 ALB ADM ACE
11 pheochromocytoma 30.6 REN NPPA KNG1 EDN1 ADM ACE
12 glomerulonephritis 30.6 REN ALB AGTR1 ACE
13 adrenal adenoma 30.6 REN NR3C2 ADM
14 acute kidney failure 30.5 REN NPPA KNG1 ALB ACE
15 carotid stenosis 30.5 REN NOS3 ACE
16 aortic aneurysm 30.5 REN NOS3 ALB AGTR1 ACE
17 essential thrombocythemia 30.4 REN AGTR1 AGT ACE
18 aortic dissection 30.4 NOS3 ALB ACE
19 aortic aneurysm, familial abdominal, 1 30.3 REN NOS3 ALB AGTR1 ACE
20 cardiogenic shock 30.3 NPPB NPPA
21 aortic valve disease 2 30.3 REN NPPB NPPA AGT ACE
22 hypertensive retinopathy 30.3 REN NR3C2 ALB ACE
23 cerebrovascular disease 30.3 REN ALB AGTR1 AGT ACE
24 chronic pyelonephritis 30.3 REN ALB ACE
25 pure autonomic failure 30.3 REN NPPA ACE
26 renal tuberculosis 30.3 REN ALB
27 microvascular complications of diabetes 1 30.2 EDN1 AGT ADM
28 uremia 30.2 REN ALB ACE
29 polycythemia 30.2 REN EDN1 ACE
30 focal segmental glomerulosclerosis 30.2 REN ALB AGTR1 AGT ACE
31 generalized atherosclerosis 30.2 REN ALB ACE
32 peripheral vascular disease 30.1 REN NOS3 EDN1 ALB ACE
33 hypertensive encephalopathy 30.1 REN EDN1 ALB AGTR1 ACE
34 aortic disease 30.1 REN NPPB ALB ACE
35 hydronephrosis 30.1 REN ALB AGTR2
36 angina pectoris 30.0 NPPB NOS3 KNG1 EDN1 ACE
37 aortic valve insufficiency 30.0 REN NPPB ALB ACE
38 hypertensive nephropathy 30.0 ALB ACE
39 microvascular complications of diabetes 3 30.0 REN ALB AGTR1 ACE
40 nephrotic syndrome 30.0 REN NPPA EDN1 ALB AGTR1 AGT
41 transient cerebral ischemia 30.0 REN NPPB ALB ACE
42 ischemia 30.0 NPPB NOS3 KNG1 EDN1 ADM ACE
43 retinal vascular disease 29.9 REN NOS3 ALB ACE
44 myocarditis 29.9 NPPB NPPA EDN1 ALB AGTR1 ACE
45 arteriolosclerosis 29.9 REN ALB ACE
46 rapidly progressive glomerulonephritis 29.9 REN ALB ACE
47 intermediate coronary syndrome 29.8 REN NPPB EDN1 ALB ACE
48 limb ischemia 29.8 NOS3 ALB ACE
49 cystic kidney disease 29.8 REN PKD1 ALB ACE
50 acute kidney tubular necrosis 29.8 REN NPPA ALB ACE

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to Renovascular Hypertension

Symptoms & Phenotypes for Renovascular Hypertension

MGI Mouse Phenotypes related to Renovascular Hypertension:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 10.41 ACE ADM AGT AGTR1 AGTR2 ALB
2 homeostasis/metabolism MP:0005376 10.35 ACE ADM AGT AGTR1 AGTR2 ALB
3 muscle MP:0005369 10.33 ADM AGT AGTR2 ALB ATP6AP2 CYBB
4 nervous system MP:0003631 10.27 AGT AGTR1 AGTR2 ATP6AP2 CYBB EDN1
5 cardiovascular system MP:0005385 10.19 ACE ADM AGT AGTR1 AGTR2 ALB
6 growth/size/body region MP:0005378 10.17 ACE AGT AGTR1 AGTR2 CYBB EDN1
7 liver/biliary system MP:0005370 10.03 ACE ADM AGT ALB ATP6AP2 NCF1
8 immune system MP:0005387 10 ACE ADM AGT AGTR1 AGTR2 ALB
9 adipose tissue MP:0005375 9.95 ACE AGT AGTR1 AGTR2 CYBB NOS3
10 hematopoietic system MP:0005397 9.77 ACE ADM AGTR1 AGTR2 CYBB KLK4
11 mortality/aging MP:0010768 9.53 ACE ADM AGT AGTR1 AGTR2 ALB

Drugs & Therapeutics for Renovascular Hypertension

Drugs for Renovascular Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 4
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
3
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 11128-99-7, 4474-91-3 172198
4
Candesartan cilexetil Approved Phase 3 145040-37-5
5
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
6
Candesartan Experimental Phase 3 139481-59-7 2541
7 Angiotensin Receptor Antagonists Phase 3
8 Amlodipine, atorvastatin drug combination Phase 3
9
Angiotensinogen Phase 3 16133225
10 Angiotensin II Type 1 Receptor Blockers Phase 3
11 Giapreza Phase 3
12 Albumin-Bound Paclitaxel Phase 3
13 Antimitotic Agents Phase 3
14 Tubulin Modulators Phase 3
15
Lidocaine Approved, Vet_approved 137-58-6 3676
16
Heparin, bovine Approved, Investigational, Withdrawn 9005-49-6 22833565 9812414 772
17 Fibrinolytic Agents
18 Anesthetics, Local
19 Pharmaceutical Solutions
20 Calcium heparin
21 Anesthetics
22 Angiotensin-Converting Enzyme Inhibitors
23 Anticholesteremic Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing the Progression of Renal Failure in Atherosclerotic Renovascular Disease Unknown status NCT01023373 Phase 4 Medical treatment
2 Percutaneous Renal Stenting in Renovascular Disease With or Without Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
3 Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) Completed NCT00081731 Phase 3 Atacand/HCT, Caduet
4 Comparison of Drug-eluting Balloon and Plain Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis: a Randomized Controlled Study Recruiting NCT04366596 Phase 3
5 A Phase 2a, Placebo-controlled Trial to Evaluate the Impact of Intravenous Bendavia™ on Ischemia Reperfusion Injury in Atherosclerotic Renal Artery Stenosis in Patients Undergoing Percutaneous Transluminal Angioplasty of the Renal Artery Terminated NCT01755858 Phase 1, Phase 2 Bendavia;Placebo
6 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension : Phase 1 Trial of Mesenchymal Stem Cell Therapy Completed NCT02266394 Phase 1 Mesenchymal stem cell
7 Phase I Study of Autologous Mesenchymal Stem Cells in the Treatment of Atherosclerotic Renal Artery Stenosis Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
8 Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (AMI) Included in the Romanian National Programme of Primary Percutaneous Revascularisation - a Single Center Observational Study Unknown status NCT02388139
9 Assessment of Renal Artery Stenosis and Renovascular Hypertension by Contrast Enhanced Magnetic Resonance Imaging: A Pilot Study Completed NCT00006173
10 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738
11 ARTISAN: iCAST™ RX De Novo Stent Placement for the Treatment of Atherosclerotic Renal Artery Stenosis in Patients With Resistant Hypertension Completed NCT01673373
12 A Prospective Danish National Registry of Percutaneous Transluminal Renal Angioplasty in Patients With Renovascular Hypertension Recruiting NCT02770066
13 A Multicenter Registry of Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Fenoldopam
Fenoldopam Mesylate

Cochrane evidence based reviews: hypertension, renovascular

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

Organs/tissues related to Renovascular Hypertension:

MalaCards : Kidney, Bone Marrow, Smooth Muscle, Endothelial, Heart, Medulla Oblongata, Cardiac Myocytes

Publications for Renovascular Hypertension

Articles related to Renovascular Hypertension:

(show top 50) (show all 5106)
# Title Authors PMID Year
1
Divergences in antihypertensive therapy in special situations in nephrology. 53 62
18425285 2008
2
Pre-operative renal function and selective renal vein renin levels as markers of favourable outcome in renovascular hypertension. 53 62
18062531 2007
3
Pre-operative renal function and selective renal vein renin levels as markers of favourable outcome in renovascular hypertension. 53 62
17489524 2007
4
Assessment of renal artery stenosis severity by pressure gradient measurements. 53 62
17084261 2006
5
Reversible renin-dependent renovascular hypertension successfully treated with percutaneous transluminal renal angioplasty and stenting. 53 62
15876819 2005
6
Renovascular hypertension. 53 62
15695858 2005
7
[Should renal vein catheterization for selective renin determination be performed in patients with suspected renovascular hypertension?]. 53 62
15515466 2004
8
Plasma adrenomedullin concentrations in patients with renovascular or malignant hypertension. 53 62
15284680 2004
9
Encapsulated transgene cells attenuate hypertension, cardiac hypertrophy and enhance renal function in Goldblatt hypertensive rats. 53 62
15241786 2004
10
Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives. 53 62
15198480 2004
11
Cyclooxygenase-2 up-regulation in reflux nephropathy. 53 62
14501677 2003
12
NT-proANP and BNP in renovascular and in severe and mild essential hypertension. 53 62
12697975 2003
13
Phase-contrast magnetic resonance flow quantification in renal arteries: comparison with 133Xenon washout measurements. 53 62
12511539 2003
14
On the significance of renal vein renins in renovascular hypertension. 53 62
12011641 2002
15
Renal vein renin measurements accurately identify renovascular hypertension caused by total occlusion of the renal artery. 53 62
12011659 2002
16
Treatment options for renovascular hypertension. 53 62
11934344 2002
17
Hypertension and renovascular disease: follow-up on 100 renal vein renin samplings. 53 62
11967722 2002
18
ACE inhibition is superior to angiotensin receptor blockade for renography in renal artery stenosis. 53 62
12002704 2002
19
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model. 53 62
11875308 2002
20
The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism? 53 62
11791020 2002
21
[Nephrourology and nuclear medicine today]. 53 62
11512405 2001
22
Prostaglandin I(2)/E(2) ratios in unilateral renovascular hypertension of different severities. 53 62
11463755 2001
23
Adrenomedullin gene delivery attenuates renal damage and cardiac hypertrophy in Goldblatt hypertensive rats. 53 62
11352835 2001
24
[Converting enzyme inhibitors in the diagnosis of secondary arterial hypertension --focus on the captopril test]. 53 62
11301909 2000
25
Functional testing: renin studies. 53 62
11022895 2000
26
The pathophysiology of renin release in renovascular hypertension. 53 62
11022891 2000
27
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. 53 62
10930193 2000
28
Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor. 53 62
10604545 1999
29
ACE inhibition scintigraphy in the management of hypertension in children. 53 62
10452277 1999
30
Radionuclide renography: a personal approach. 53 62
10321824 1999
31
Short-term modulation of the renin-angiotensin system does not alter plasma adrenomedullin concentration in humans. 53 62
9886897 1998
32
[Current pharmaco-therapeutic strategies in the treatment of arterial hypertension]. 53 62
9813738 1998
33
Endothelin and active renin levels in essential hypertension and hypertension with renal artery stenosis before and after percutaneous transluminal renal angioplasty. 53 62
9488241 1997
34
[Nuclear nephrology]. 53 62
9494337 1997
35
Renovascular hypertension with low-to-normal plasma renin: clinical and angiographic features. 53 62
9486089 1997
36
Plasma endothelin-1 level in patients with renovascular hypertension - does the kidney with stenosis of the renal artery upregulate production of endthelin-1? 53 62
9233908 1997
37
Consensus report on ACE inhibitor renography for detecting renovascular hypertension. Radionuclides in Nephrourology Group. Consensus Group on ACEI Renography. 53 62
8917196 1996
38
Renal extraction of atrial natriuretic peptide in hypertensive patients with or without renal artery stenosis. 53 62
8641732 1996
39
[Comparison of captopril angioscintigraphy and the renin test in diagnosis of renovascular hypertension]. 53 62
8755852 1996
40
Acute blockage of the renin system and differential renal vein renin determinations in the diagnosis of renovascular hypertension. 53 62
8727869 1996
41
Renovascular hypertension in blacks. 53 62
8834702 1996
42
Reversible nephrotic syndrome due to high renin state in renovascular hypertension. 53 62
7731487 1995
43
Effect of chronic ACE inhibition on the diagnostic value of renography for renovascular hypertension: a preliminary report. 53 62
7753462 1995
44
Regulation of the structural remodelling of the myocardium: from hypertrophy to heart failure. 53 62
7713113 1994
45
[Renal ablation by transcatheter renal arterial embolization in the treatment of benign renal disease]. 53 62
9261190 1994
46
Response to the captopril test is dependent on baseline renin profile. 53 62
8021469 1994
47
Renin secretion and captopril stimulation in hypertensive renal transplant recipients. 53 62
8178382 1994
48
Captopril-stimulated renal vein renin measurements in the diagnosis of atherosclerotic renovascular hypertension. 53 62
8136101 1994
49
[Evaluation criteria for captopril-kidney function scintigraphy using 99mTc-MAG3]. 53 62
8295828 1993
50
Scintigraphic evaluation of renovascular hypertension. 53 62
8128734 1993

Variations for Renovascular Hypertension

ClinVar genetic disease variations for Renovascular Hypertension:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PKD1 NM_001009944.3(PKD1):c.9185T>A (p.Val3062Asp) SNV Likely Pathogenic
374044 rs1057518856 GRCh37: 16:2152398-2152398
GRCh38: 16:2102397-2102397

Expression for Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for Renovascular Hypertension

Pathways related to Renovascular Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 13.27 SUCNR1 NOS3 NCF1 KNG1 EDN1 CYBB
2
Show member pathways
13.15 SUCNR1 KNG1 EDN1 AGTR2 AGTR1 AGT
3
Show member pathways
11.94 REN ATP6AP2 AGT ACE
4
Show member pathways
11.79 NPPB NPPA EDN1 AGT
5 11.47 NPPA EDN1 AGT
6
Show member pathways
11.33 REN NR3C2 NOS3 KNG1 ATP6AP2 AGTR2
7
Show member pathways
11.32 NOX4 NCF1 CYBB
8 11.19 NPPB NPPA NOS3
9
Show member pathways
11.02 ACE AGTR1 AGTR2
10 10.58 NOX4 AGTR1 AGT

GO Terms for Renovascular Hypertension

Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 REN NPPB NPPA KNG1 EDN1 ATP6AP2
2 NADPH oxidase complex GO:0043020 9.1 NOX4 NCF1 CYBB

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.4 NOX4 KNG1 CYBB AGTR2 AGTR1 ADM
2 positive regulation of inflammatory response GO:0050729 10.22 ACE AGT AGTR1 SUCNR1
3 response to lipopolysaccharide GO:0032496 10.22 ACE ADM EDN1 NOS3 REN
4 female pregnancy GO:0007565 10.21 NPPA AGT ADM ACE
5 kidney development GO:0001822 10.19 REN PKD1 AGTR1 AGT ACE
6 positive regulation of cytosolic calcium ion concentration GO:0007204 10.18 PKD1 KNG1 EDN1 AGTR1 AGT ADM
7 positive regulation of protein tyrosine kinase activity GO:0061098 10.12 NOX4 AGT ACE
8 positive regulation of nitric oxide biosynthetic process GO:0045429 10.12 AGT AGTR2 EDN1
9 positive regulation of heart rate GO:0010460 10.08 NPPA EDN1 ADM
10 blood vessel remodeling GO:0001974 10.06 ACE AGT AGTR2 NOS3
11 superoxide metabolic process GO:0006801 10.04 NOX4 NCF1 CYBB
12 nitric oxide mediated signal transduction GO:0007263 10.02 NOS3 AGTR2 AGT
13 positive regulation of renal sodium excretion GO:0035815 9.99 NPPB EDN1 AGT
14 positive regulation of CoA-transferase activity GO:1905920 9.97 AGTR1 AGT
15 angiotensin-activated signaling pathway GO:0038166 9.97 AGTR2 AGTR1
16 superoxide anion generation GO:0042554 9.97 CYBB EDN1 NCF1 NOX4
17 response to fluid shear stress GO:0034405 9.96 PKD1 NOS3
18 positive regulation of NAD(P)H oxidase activity GO:0033864 9.96 AGTR1 AGT
19 body fluid secretion GO:0007589 9.96 NPPB EDN1
20 vasoconstriction GO:0042310 9.96 EDN1 AGT ACE
21 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.95 NOS3 EDN1
22 angiotensin maturation GO:0002003 9.95 REN ATP6AP2 ACE
23 reactive oxygen species biosynthetic process GO:1903409 9.94 NOX4 NCF1
24 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.93 AGTR2 AGT
25 regulation of renal sodium excretion GO:0035813 9.93 AGTR1 AGT
26 vasodilation GO:0042311 9.93 AGT AGTR2 KNG1 NOS3 NPPA NPPB
27 regulation of vasoconstriction GO:0019229 9.92 EDN1 AGTR1 AGT ACE
28 maintenance of blood vessel diameter homeostasis by renin-angiotensin GO:0002034 9.91 AGTR1 AGT
29 regulation of renal output by angiotensin GO:0002019 9.89 ACE AGT
30 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.88 AGT AGTR2
31 regulation of angiotensin metabolic process GO:0060177 9.88 ACE SUCNR1
32 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.83 AGTR1 AGT ACE
33 regulation of blood pressure GO:0008217 9.83 REN NPPB NPPA NOS3 EDN1 AGTR2
34 renin-angiotensin regulation of aldosterone production GO:0002018 9.73 REN AGTR1 AGT
35 regulation of blood volume by renin-angiotensin GO:0002016 9.71 REN AGT
36 blood vessel diameter maintenance GO:0097746 9.44 NPPB NPPA NOS3 KNG1 EDN1 AGTR2

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 10 REN NPPB NPPA KNG1 EDN1 ADM
2 hormone receptor binding GO:0051427 9.71 NPPB NPPA
3 angiotensin type II receptor activity GO:0004945 9.67 AGTR2 AGTR1
4 bradykinin receptor binding GO:0031711 9.46 ACE AGTR1
5 superoxide-generating NAD(P)H oxidase activity GO:0016175 9.43 NOX4 NCF1 CYBB
6 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor GO:0050664 9.32 NOX4 CYBB
7 hormone activity GO:0005179 9.32 NPPB NPPA EDN1 AGT ADM

Sources for Renovascular Hypertension

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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