MCID: RNV001
MIFTS: 49

Renovascular Hypertension

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renovascular Hypertension

MalaCards integrated aliases for Renovascular Hypertension:

Name: Renovascular Hypertension 12 6 15
Hypertension, Renovascular 44 73
Hypertension Renovascular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1591
ICD10 33 I15.0
MeSH 44 D006978
NCIt 50 C85044
SNOMED-CT 68 123799005 194790006
UMLS 73 C0020545

Summaries for Renovascular Hypertension

MalaCards based summary : Renovascular Hypertension, also known as hypertension, renovascular, is related to malignant renovascular hypertension and hypertensive retinopathy. An important gene associated with Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Calcium signaling pathway and Fluid shear stress and atherosclerosis. The drugs Angiotensin Receptor Antagonists and Angiotensin-Converting Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Renovascular hypertension (or \"renal hypertension\") is a condition in which high blood pressure is... more...

Related Diseases for Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 malignant renovascular hypertension 34.6 EDN1 REN
2 hypertensive retinopathy 31.0 ACE REN
3 renal tuberculosis 30.4 EDN1 REN
4 renal hypertension 30.4 ACE ADM AGTR1 EDN1 REN
5 fibromuscular dysplasia 30.3 ACE AGTR1 REN
6 hypertension, diastolic 30.3 ACE NPPA REN
7 ischemia 29.8 ACE EDN1 HMOX1 NOS3
8 pheochromocytoma 29.6 ADM NF1 NPPA
9 nephrosclerosis 29.0 ACE AGTR1
10 pulmonary edema 28.8 ACE EDN1 HMOX1 NOS3 REN
11 aortic coarctation 28.6 ACE AGTR1 EDN1 NOS3
12 chronic kidney failure 28.2 ACE AGTR1 EDN1 NPPA REN
13 kidney disease 28.2 ACE AGTR1 EDN1 NPPA REN
14 diabetes mellitus, noninsulin-dependent 28.1 ACE AGTR1 EDN1 NOS3
15 arteries, anomalies of 28.1 ACE AGTR1 EDN1 NOS3 REN
16 vascular disease 27.9 ACE CAT EDN1 HMOX1 NOS3 REN
17 congestive heart failure 27.5 ACE ADM AGTR1 EDN1 NPPA REN
18 hypertension, essential 27.1 ACE ADM AGTR1 EDN1 NOS3 NPPA
19 benign renovascular hypertension 12.1
20 hyporeninemic hypoaldosteronism 10.8 ACE REN
21 renal artery obstruction 10.8 ACE REN
22 hypertensive encephalopathy 10.7 ACE REN
23 postural hypotension 10.7 NPPA REN
24 orthostatic proteinuria 10.7 ACE REN
25 malignant secondary hypertension 10.7 EDN1 REN
26 atrial septal defect 4 10.7 ACE REN
27 perinephritis 10.7 EDN1 REN
28 malignant essential hypertension 10.6 ACE REN
29 syndrome of inappropriate antidiuretic hormone 10.6 ACE NPPA
30 central sleep apnea 10.6 NOS3 NPPA
31 acute poststreptococcal glomerulonephritis 10.6 EDN1 NPPA
32 coronary artery vasospasm 10.5 EDN1 NOS3
33 chronic mountain sickness 10.5 EDN1 NOS3
34 ischemic heart disease 10.5 ACE NOS3
35 mitral valve insufficiency 10.5 ACE NPPA
36 hypoaldosteronism 10.5 ACE NPPA REN
37 pure autonomic failure 10.4 ACE NPPA REN
38 optic nerve neoplasm 10.4 ACE NF1
39 aortic valve disease 2 10.4 ACE NPPA REN
40 apnea, obstructive sleep 10.4 EDN1 REN
41 idiopathic hypercalciuria 10.4 EDN1 NPPA REN
42 endotheliitis 10.4
43 urinary system disease 10.4 ACE EDN1 REN
44 arteritic anterior ischemic optic neuropathy 10.3 ACE NOS3
45 vasculogenic impotence 10.3 ACE NOS3 NPPA
46 glucose metabolism disease 10.3 ACE NOS3 REN
47 persistent fetal circulation syndrome 10.3 EDN1 NOS3
48 ureteral disease 10.3 ACE REN
49 hepatic vascular disease 10.3 EDN1 NOS3 REN
50 acquired metabolic disease 10.3 ACE NOS3 REN

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to Renovascular Hypertension

Symptoms & Phenotypes for Renovascular Hypertension

MGI Mouse Phenotypes related to Renovascular Hypertension:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ACE EDN1 ADM HMOX1 AGTR1 NF1
2 homeostasis/metabolism MP:0005376 10.14 ACE CAT EDN1 ADM HMOX1 AGTR1
3 behavior/neurological MP:0005386 10.11 AGTR1 ACE ADM HMOX1 NF1 NOS1
4 hematopoietic system MP:0005397 10.09 ACE ADM HMOX1 AGTR1 NPPA NOS1
5 growth/size/body region MP:0005378 10.06 AGTR1 ACE EDN1 HMOX1 NOS3 NF1
6 endocrine/exocrine gland MP:0005379 10.02 ACE EDN1 ADM HMOX1 NF1 NOS1
7 immune system MP:0005387 9.97 AGTR1 ACE ADM HMOX1 NF1 NOS1
8 mortality/aging MP:0010768 9.96 AGTR1 ACE CAT EDN1 ADM HMOX1
9 adipose tissue MP:0005375 9.92 AGTR1 ACE HMOX1 NOS1 NOS3
10 liver/biliary system MP:0005370 9.8 ACE ADM HMOX1 NF1 NOS1 NOS3
11 muscle MP:0005369 9.76 EDN1 ADM HMOX1 NPPA NOS1 REN
12 renal/urinary system MP:0005367 9.65 ACE EDN1 ADM HMOX1 AGTR1 NF1
13 reproductive system MP:0005389 9.1 ACE ADM HMOX1 NOS3 REN NOS1

Drugs & Therapeutics for Renovascular Hypertension

Drugs for Renovascular Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Angiotensin Receptor Antagonists
2 Angiotensin-Converting Enzyme Inhibitors
3 Antihypertensive Agents
4 Anticholesteremic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
2 MSC for Occlusive Disease of the Kidney Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
3 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
4 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Recruiting NCT02266394 Phase 1 Mesenchymal stem cell
5 Magnetic Resonance Imaging for Evaluating Kidney Function Completed NCT00006173
6 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
7 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable
8 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
9 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Active, not recruiting NCT01673373 Not Applicable

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypertension, renovascular

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

MalaCards organs/tissues related to Renovascular Hypertension:

41
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes

Publications for Renovascular Hypertension

Articles related to Renovascular Hypertension:

(show top 50) (show all 699)
# Title Authors Year
1
Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension. ( 29331564 )
2018
2
Renovascular hypertension: endovascular therapy in complicated aortic Stanford type B dissection. ( 29850408 )
2018
3
Borderline bilateral renal artery stenosis assessed with high-resolution angiography, intravascular ultrasound, and renal fractional flow reserve in a patient with renovascular hypertension. ( 29756199 )
2018
4
Possible interesting link between Janus kinase 2 mutation and renovascular hypertension. ( 29656557 )
2018
5
Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. ( 29656438 )
2018
6
Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension. ( 29842964 )
2018
7
Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection. ( 29590257 )
2018
8
Direct Recording of Cardiac and Renal Sympathetic Nerve Activity Shows Differential Control in Renovascular Hypertension. ( 29686011 )
2018
9
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension. ( 29425960 )
2018
10
Current Concepts in the Treatment of Renovascular Hypertension. ( 28985335 )
2018
11
Renovascular hypertension in small children-is it Takayasu arteritis or fibromuscular dysplasia? ( 29861130 )
2018
12
Chronic intermittent hypoxia and renovascular hypertension: A case of one plus one equals one-half! ( 29377392 )
2018
13
Neonatal renovascular hypertension. ( 29878627 )
2018
14
Is there still a role for renal artery stenting in the management of renovascular hypertension - A single-center experience and where do we stand in 2018? ( 29934065 )
2018
15
Fibromuscular Dysplasia: Another Paradigm Shift in Renovascular Hypertension? ( 29709956 )
2018
16
Correction to: Comments on Chavent et al.: Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 29404688 )
2018
17
A Unique Case of Renovascular Hypertension due to Fibromuscular Dysplasia in an Extra-renal Artery. ( 29709926 )
2018
18
Atrial secretion of ANP is suppressed in renovascular hypertension: shifting of ANP secretion from atria to the left ventricle. ( 29979625 )
2018
19
Interventions in children with renovascular hypertension: A 27-year retrospective single-center experience. ( 29635838 )
2018
20
Renal resistive index for renovascular hypertension: In the quest of the Holy Grail. ( 29450962 )
2018
21
Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension. ( 29872089 )
2018
22
ACR Appropriateness Criteria<sup>Ar</sup>Renovascular Hypertension. ( 29101991 )
2017
23
Sonographic evaluation of renovascular hypertension in the pediatric population: State-of-the-art. ( 28370243 )
2017
24
Lotus Root Sign in the Renal Artery in Renovascular Hypertension. ( 28250287 )
2017
25
Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension. ( 28622281 )
2017
26
Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT<sub>1</sub>R-NADPH oxidase pathway. ( 29274384 )
2017
27
Treatment outcomes according to underlying disease in pediatric renovascular hypertension. ( 29281158 )
2017
28
New Insights Into Pathophysiology, Diagnosis, and Treatment of Renovascular Hypertension. ( 28270639 )
2017
29
Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes. ( 28347166 )
2017
30
Successful long-term effects of direct renin inhibitor aliskiren in a patient with atherosclerotic renovascular hypertension. ( 28509129 )
2017
31
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. ( 28275232 )
2017
32
Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of<i>Acanthospermum hispidum</i>DC. on Ovariectomized Rats with Renovascular Hypertension. ( 29234376 )
2017
33
Complex glomerular pathology of thrombotic microangiopathy and focal segmental glomerulosclerosis forms tumor-like mass in a renal transplant donor with severe renovascular hypertension. ( 28509120 )
2017
34
Unenhanced renal magnetic resonance angiography in patients with chronic kidney disease &amp;amp; suspected renovascular hypertension: Can it affect patient management? ( 29578191 )
2017
35
Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension. ( 28315847 )
2017
36
Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. ( 29073282 )
2017
37
Revisiting angioplasty for renovascular hypertension. ( 28852488 )
2017
38
Transplantation of bone marrow-derived MSCs improves renal function and Na(+)+K(+)-ATPase activity in rats with renovascular hypertension. ( 28374150 )
2017
39
Comments on Chavent et al.: Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28695307 )
2017
40
Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension. ( 28945940 )
2017
41
Treatment of severe hypertension in a 14-year-old child: Successful blood pressure control with additive administration of captopril, an angiotensin-converting enzyme inhibitor, in a patient with bilateral renovascular hypertension. ( 28621587 )
2017
42
Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28429121 )
2017
43
Iron restriction in renovascular hypertension. ( 28250410 )
2017
44
Long-Term Outcomes of Pediatric Renovascular Hypertension. ( 28950261 )
2017
45
Renovascular hypertension: results in adulthood of renal autotransplantation performed in children-response to comments by Della Schiava and Lermusiaux. ( 28695308 )
2017
46
The management of pediatric renovascular hypertension: a single center experience and review of the literature. ( 29397961 )
2017
47
Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging. ( 28560752 )
2017
48
Antihypertensive Effects of Hydroalcoholic Extract of Crataegus Azarolus Subspecies Aronia Fruit in Rats with Renovascular Hypertension: An Experimental Mechanistic Study. ( 28533575 )
2017
49
Management of Renovascular Hypertension. ( 27641455 )
2016
50
Prior renovascular hypertension does not predispose to atherosclerosis in mice. ( 27100924 )
2016

Variations for Renovascular Hypertension

ClinVar genetic disease variations for Renovascular Hypertension:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PKD1 NM_000296.3(PKD1): c.9185T> A (p.Val3062Asp) single nucleotide variant Likely pathogenic rs1057518856 GRCh37 Chromosome 16, 2152398: 2152398
2 PKD1 NM_000296.3(PKD1): c.9185T> A (p.Val3062Asp) single nucleotide variant Likely pathogenic rs1057518856 GRCh38 Chromosome 16, 2102397: 2102397

Expression for Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for Renovascular Hypertension

Pathways related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 AGTR1 NOS1 NOS3
2 11.81 EDN1 HMOX1 NOS3
3 11.79 AGTR1 NOS1 NOS3
4 11.6 AGTR1 EDN1 NOS3
5 11.53 HMOX1 NOS3 REN
6 11.31 ADM EDN1 HMOX1
7 11.26 EDN1 HMOX1 NOS3 NPPA
8 11.25 ACE AGTR1 REN
9 11.11 EDN1 NOS3
10 11.1 HMOX1 NOS3
11 11.05 CAT HMOX1
12 10.99 NOS1 NOS3
13
Show member pathways
10.94 NOS1 NOS3
14
Show member pathways
10.93 CAT NOS1 NOS3
15 10.89 NOS1 NOS3
16
Show member pathways
10.83 ACE AGTR1 NOS3 REN
17 10.57 NOS1 NOS3
18 10.27 NOS1 NOS3

GO Terms for Renovascular Hypertension

Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACE ADM CAT EDN1 HMOX1 NPPA
2 vesicle membrane GO:0012506 9.16 NOS1 NOS3
3 caveola GO:0005901 9.13 HMOX1 NOS1 NOS3

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.93 ADM HMOX1 NF1 NOS3
2 heart development GO:0007507 9.85 ADM EDN1 NF1
3 positive regulation of angiogenesis GO:0045766 9.82 ADM HMOX1 NOS3
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.81 ADM AGTR1 EDN1
5 response to insulin GO:0032868 9.74 ADM CAT NPPA
6 regulation of angiogenesis GO:0045765 9.68 HMOX1 NF1
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.67 HMOX1 NOS3
8 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.67 AGTR1 EDN1
9 blood vessel remodeling GO:0001974 9.67 ACE NOS3
10 kidney development GO:0001822 9.67 ACE AGTR1 CAT REN
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.66 EDN1 NF1
12 negative regulation of blood pressure GO:0045776 9.66 NOS1 NOS3
13 vasodilation GO:0042311 9.65 NOS1 NOS3
14 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.65 AGTR1 HMOX1
15 regulation of sodium ion transport GO:0002028 9.65 NOS1 NOS3
16 response to lipopolysaccharide GO:0032496 9.65 ADM EDN1 NOS1 NOS3 REN
17 nitric oxide mediated signal transduction GO:0007263 9.63 NOS1 NOS3
18 response to muscle stretch GO:0035994 9.62 EDN1 NPPA
19 amyloid-beta metabolic process GO:0050435 9.62 ACE REN
20 regulation of blood vessel diameter GO:0097746 9.61 ACE AGTR1
21 negative regulation of calcium ion transport GO:0051926 9.61 NOS1 NOS3
22 positive regulation of blood vessel diameter GO:0097755 9.61 ADM HMOX1 NOS3
23 nitric oxide biosynthetic process GO:0006809 9.6 NOS1 NOS3
24 angiotensin maturation GO:0002003 9.59 ACE REN
25 positive regulation of guanylate cyclase activity GO:0031284 9.58 NOS1 NOS3
26 negative regulation of potassium ion transport GO:0043267 9.58 NOS1 NOS3
27 regulation of vasoconstriction GO:0019229 9.58 ACE AGTR1 EDN1
28 arginine catabolic process GO:0006527 9.56 NOS1 NOS3
29 negative regulation of hydrolase activity GO:0051346 9.55 NOS1 NOS3
30 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 9.54 NOS1 NPPA
31 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.52 ACE AGTR1
32 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.51 EDN1 NOS3
33 positive regulation of heart rate GO:0010460 9.5 ADM EDN1 NPPA
34 response to ozone GO:0010193 9.49 CAT EDN1
35 renin-angiotensin regulation of aldosterone production GO:0002018 9.48 AGTR1 REN
36 smooth muscle hyperplasia GO:0014806 9.46 HMOX1 NOS3
37 regulation of blood vessel size GO:0050880 9.46 EDN1 NOS1 NOS3 NPPA
38 regulation of blood pressure GO:0008217 9.43 ACE EDN1 HMOX1 NOS3 NPPA REN
39 response to hypoxia GO:0001666 9.17 ADM CAT EDN1 HMOX1 NF1 NOS1

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.83 CAT HMOX1 NOS1 NOS3
2 hormone activity GO:0005179 9.65 ADM EDN1 NPPA
3 signaling receptor binding GO:0005102 9.65 ADM CAT EDN1 NPPA REN
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.51 NOS1 NOS3
5 FMN binding GO:0010181 9.49 NOS1 NOS3
6 arginine binding GO:0034618 9.46 NOS1 NOS3
7 NADPH-hemoprotein reductase activity GO:0003958 9.43 NOS1 NOS3
8 cadmium ion binding GO:0046870 9.4 NOS1 NOS3
9 tetrahydrobiopterin binding GO:0034617 9.37 NOS1 NOS3
10 NADP binding GO:0050661 9.33 CAT NOS1 NOS3
11 nitric-oxide synthase activity GO:0004517 9.32 NOS1 NOS3
12 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
13 heme binding GO:0020037 8.92 CAT HMOX1 NOS1 NOS3

Sources for Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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