Reproductive Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050622

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Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to male reproductive organ benign neoplasm and vestibular gland benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Th1 Differentiation Pathway and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include lung, ovary and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)

#	Related Disease	Score	Top Affiliating Genes
1	male reproductive organ benign neoplasm	34.0	AFP CYP19A1 DICER1
2	vestibular gland benign neoplasm	32.2	ESR1 PGR
3	vulvar benign neoplasm	32.2	ESR1 PGR
4	ovarian benign neoplasm	32.1	CYP19A1 FH
5	uterine benign neoplasm	29.6	CD3E ESR1 FH GNRH1 HMGA2 HPSE2
6	cervical benign neoplasm	11.2
7	fallopian tube benign neoplasm	11.2
8	vaginal benign neoplasm	11.2
9	bartholin's gland adenoma	10.3	ESR1 PGR
10	bizarre leiomyoma	10.3	MED12 PGR
11	vulvar syringoma	10.3	ESR1 PGR
12	pleomorphic lipoma	10.3	HMGA2 PGR
13	glassy cell carcinoma of the cervix	10.3	ESR1 PGR
14	lung leiomyoma	10.3	ESR1 PGR
15	trigonitis	10.3	ESR1 PGR
16	vulvar leiomyoma	10.3	ESR1 PGR
17	mixed hepatoblastoma	10.3	AFP PGR
18	breast medullary carcinoma	10.3	ESR1 PGR
19	breast scirrhous carcinoma	10.3	ESR1 PGR
20	bartholin's gland benign neoplasm	10.3	ESR1 PGR
21	oncocytic breast carcinoma	10.2	ESR1 PGR
22	progesterone resistance	10.2	ESR1 PGR
23	endometrial squamous cell carcinoma	10.2	ESR1 PGR
24	cribriform carcinoma	10.2	ESR1 PGR
25	testicular granulosa cell tumor	10.2	AFP DICER1
26	endometrial mucinous adenocarcinoma	10.2	ESR1 PGR
27	juvenile type testicular granulosa cell tumor	10.2	AFP DICER1
28	adenoid basal cell carcinoma	10.2	ESR1 PGR
29	breast adenoid cystic carcinoma	10.2	ESR1 PGR
30	apocrine adenocarcinoma	10.2	ESR1 PGR
31	cystic nephroma	10.2	DICER1 PGR
32	deep angioma	10.2	ESR1 PGR
33	synchronous bilateral breast carcinoma	10.2	ESR1 PGR
34	benign metastasizing leiomyoma	10.2	CYP19A1 PGR
35	breast benign neoplasm	10.2	ESR1 MED12 PGR
36	thoracic benign neoplasm	10.2	ESR1 MED12 PGR
37	female reproductive endometrioid cancer	10.2	ESR1 PGR
38	cervical carcinosarcoma	10.2	ESR1 PGR
39	scrotal carcinoma	10.2	AFP HMGA2
40	smooth muscle tumor	10.2	ESR1 HMGA2 PGR
41	intramuscular hemangioma	10.2	ESR1 PGR
42	glycogen-rich clear cell breast carcinoma	10.2	ESR1 PGR
43	leiomyosarcoma	10.2	FH MED12 PGR
44	gynandroblastoma	10.2	CALB2 DICER1
45	tubular adenocarcinoma	10.2	AFP ESR1 PGR
46	cervical clear cell adenocarcinoma	10.1	ESR1 PGR
47	progesterone-receptor positive breast cancer	10.1	CYP19A1 ESR1 PGR
48	gender identity disorder	10.1	CYP19A1 ESR1 PGR
49	estrogen excess	10.1	CYP19A1 ESR1 PGR
50	mammographic density	10.1	CYP19A1 ESR1 PGR

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:

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Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-108	9.62	DICER1 MED12 PRDM10
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.62	MED12
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.62	MED12
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.62	MED12
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.62	PRDM10
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.62	PRDM10
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.62	DICER1 MED12
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.62	MED12
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	9.62	PRDM10
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.62	MED12
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.62	DICER1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.62	MED12
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-3	9.62	DICER1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.62	DICER1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.62	MED12
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.62	DICER1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.62	MED12

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	10.07	AFP CD3E DICER1 ESR1 FH HPSE2
2	neoplasm	MP:0002006	9.63	AFP CD3E DICER1 ESR1 GNRH1 PGR
3	normal	MP:0002873	9.56	CALB2 CYP19A1 DICER1 ESR1 GNRH1 MED12
4	renal/urinary system	MP:0005367	9.17	CYP19A1 DICER1 ESR1 FH GNRH1 HPSE2

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Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

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Genetic Tests for Reproductive Organ Benign Neoplasm

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Anatomical Context for Reproductive Organ Benign Neoplasm

MalaCards organs/tissues related to Reproductive Organ Benign Neoplasm:

⁴¹

Lung, Ovary, Prostate, Cervix, Testis, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

¹⁹

Reproductive System Organs

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Publications for Reproductive Organ Benign Neoplasm

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Genes for Reproductive Organ Benign Neoplasm

Genes related to Reproductive Organ Benign Neoplasm (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	18.28	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	17.08	DISEASES inferred ¹⁵
3	MED12	Mediator Complex Subunit 12	Protein Coding	16.93	DISEASES inferred ¹⁵
4	DICER1	Dicer 1, Ribonuclease III	Protein Coding	16.27	DISEASES inferred ¹⁵
5	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	16.24	DISEASES inferred ¹⁵
6	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	16.14	DISEASES inferred ¹⁵
7	TLR9	Toll Like Receptor 9	Protein Coding	16.1	DISEASES inferred ¹⁵ ¹⁵
8	ESR1	Estrogen Receptor 1	Protein Coding	16.05	DISEASES inferred ¹⁵
9	FH	Fumarate Hydratase	Protein Coding	15.84	DISEASES inferred ¹⁵
10	AFP	Alpha Fetoprotein	Protein Coding	15.63	DISEASES inferred ¹⁵
11	CD3E	CD3e Molecule	Protein Coding	15.56	DISEASES inferred ¹⁵
12	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	15.54	DISEASES inferred ¹⁵
13	RAD51B	RAD51 Paralog B	Protein Coding	15.48	DISEASES inferred ¹⁵
14	PRDM10	PR/SET Domain 10	Protein Coding	15.47	DISEASES inferred ¹⁵
15	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	15.46	DISEASES inferred ¹⁵
16	TNRC6B	Trinucleotide Repeat Containing 6B	Protein Coding	15.27	DISEASES inferred ¹⁵
17	IVL	Involucrin	Protein Coding	6.51	DISEASES inferred ¹⁵
18	CALB2	Calbindin 2	Protein Coding	6.37	DISEASES inferred ¹⁵

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Variations for Reproductive Organ Benign Neoplasm

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Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

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Pathways for Reproductive Organ Benign Neoplasm

Pathways related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.25	CD3E TGFB3 TLR9
2	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶¹	9.23	CYP19A1 ESR1

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GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.91	ESR1 HMGA2 MED12 PGR TGFB3 TLR9
2	negative regulation of gene expression	GO:0010629	9.56	CD3E ESR1 PGR TNRC6B
3	uterus development	GO:0060065	9.4	CYP19A1 ESR1
4	androgen metabolic process	GO:0008209	9.37	CYP19A1 ESR1
5	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.32	ESR1 MED12
6	ovulation from ovarian follicle	GO:0001542	9.16	AFP PGR
7	embryonic neurocranium morphogenesis	GO:0048702	8.96	MED12 TGFB3
8	mammary gland development	GO:0030879	8.8	CYP19A1 PGR TGFB3

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	siRNA binding	GO:0035197	8.62	DICER1 TLR9

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