MCID: RPR001
MIFTS: 29

Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050622

Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to cervical benign neoplasm and vestibular gland benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include reproductive system, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 cervical benign neoplasm 32.6 PGR MME
2 vestibular gland benign neoplasm 32.6 TP53 PGR ESR1
3 ovarian benign neoplasm 32.6 TP53 EPPIN AMH
4 vaginal benign neoplasm 32.5 ESR2 CYP19A1 CTNNB1
5 fallopian tube benign neoplasm 32.5 TSC2 MME CALD1
6 vulvar benign neoplasm 32.4 PGR MME HMGA2 ESR1 CALD1
7 uterine benign neoplasm 30.9 TSC2 TP53 PTEN PGR MME MED12
8 male reproductive organ benign neoplasm 11.7
9 sex cord-stromal benign neoplasm 11.2
10 paratesticular lipoma 11.2
11 wolffian duct adenoma 11.2
12 prostatic adenoma 11.2
13 prostate leiomyoma 11.2
14 dartoic leiomyoma 11.2
15 rete testis adenoma 11.2
16 epididymis adenomatoid tumor 11.2
17 breast duct papilloma 10.5 PTEN PGR
18 glassy cell carcinoma of the cervix 10.5 PGR ESR1
19 breast intraductal papillomatosis 10.5 PGR ESR1
20 nipple carcinoma 10.5 PGR ESR1
21 bartholin's gland adenoid cystic carcinoma 10.5 PGR ESR1
22 chronic tympanitis 10.5 PGR ESR1
23 granulomatous endometritis 10.5 PGR ESR1
24 vulvar syringoma 10.5 PGR ESR1
25 isolated anorectal malformation 10.5 MED12 CTNNB1
26 cervical adenomyoma 10.5 PGR MME
27 nonmucinous bronchioloalveolar adenocarcinoma 10.5 ESR2 ESR1
28 vaginitis 10.5 ESR2 ESR1 EPPIN
29 bartholin's gland adenoma 10.5 TP53 PGR ESR1
30 bartholin's gland benign neoplasm 10.5 TP53 PGR ESR1
31 breast leiomyoma 10.5 PGR MME
32 fallopian tube endometriosis 10.5 PGR MME
33 liver adenomatosis 10.5 PGR CTNNB1
34 mucinous adenocarcinoma 10.5 TP53 PGR ESR1
35 ovarian seromucinous carcinoma 10.5 TP53 PGR ESR1
36 pulmonary vein leiomyosarcoma 10.5 PGR CALD1
37 adult type testicular granulosa cell tumor 10.5 PGR ESR1
38 pregnancy adenoma 10.5 PGR MED12
39 breast scirrhous carcinoma 10.5 PGR ESR1
40 comedo carcinoma 10.5 TP53 PGR ESR1
41 lung leiomyoma 10.5 PGR ESR1 CALD1
42 basaloid lung carcinoma 10.5 TP53 PGR
43 oncocytic breast carcinoma 10.5 PGR ESR1
44 cervical clear cell adenocarcinoma 10.5 PGR ESR1
45 vaginal endometrial stromal tumor 10.5 MME CALD1
46 progesterone resistance 10.5 PGR ESR2 ESR1
47 uterine corpus adenosarcoma 10.5 PGR MME ESR1
48 juvenile nasopharyngeal angiofibroma 10.5 PGR ESR1 CYP19A1
49 atrophy of prostate 10.5 TP53 GNRH1 EPPIN
50 subserous uterine fibroid 10.5 PGR CYP19A1 AMH

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:



Diseases related to Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 9.26 TP53
2 Decreased TP53 mRNA expression GR00389-S-6 9.26 ESR2 HMGA2 TP53
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 ESR2 FH PTEN

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
2 cardiovascular system MP:0005385 10.36 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 HOXA10
3 cellular MP:0005384 10.35 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 FH
4 endocrine/exocrine gland MP:0005379 10.32 AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
5 integument MP:0010771 10.29 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
6 digestive/alimentary MP:0005381 10.13 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
7 liver/biliary system MP:0005370 10.13 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
8 nervous system MP:0003631 10.13 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
9 limbs/digits/tail MP:0005371 10.11 CTNNB1 ESR1 ESR2 HOXA10 IGF1 MED12
10 neoplasm MP:0002006 10.11 AKT1 AMH CTNNB1 ESR1 ESR2 GNRH1
11 muscle MP:0005369 10.06 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 IGF1
12 normal MP:0002873 10.03 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
13 renal/urinary system MP:0005367 9.85 CTNNB1 CYP19A1 ESR1 ESR2 FH GNRH1
14 reproductive system MP:0005389 9.77 AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
15 skeleton MP:0005390 9.4 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1

Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

Genetic Tests for Reproductive Organ Benign Neoplasm

Anatomical Context for Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

19
Reproductive System

Publications for Reproductive Organ Benign Neoplasm

Variations for Reproductive Organ Benign Neoplasm

Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

Pathways for Reproductive Organ Benign Neoplasm

Pathways related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TSC2 TP53 PTEN IGF1 GNRH1 ESR2
2
Show member pathways
13.25 TSC2 IGF1 GNRH1 ESR2 ESR1 CTNNB1
3
Show member pathways
12.95 TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
4
Show member pathways
12.81 TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
5
Show member pathways
12.69 TP53 PTEN ESR1 CTNNB1 AKT1
6 12.65 TP53 PTEN IGF1 FH ESR2 ESR1
7
Show member pathways
12.64 PGR IGF1 ESR2 ESR1 AKT1
8
Show member pathways
12.59 TP53 PTEN IGF1 FH AKT1
9
Show member pathways
12.59 TSC2 IGF1 GNRH1 CTNNB1 AKT1
10
Show member pathways
12.58 TSC2 TP53 PTEN IGF1 ESR2 ESR1
11
Show member pathways
12.53 TP53 PTEN PGR IGF1 ESR2 ESR1
12 12.48 TSC2 PTEN FH CYP19A1 AKT1
13
Show member pathways
12.44 TSC2 TP53 PTEN IGF1 AKT1
14
Show member pathways
12.35 TSC2 TP53 PTEN IGF1
15
Show member pathways
12.3 IGF1 ESR2 ESR1 AKT1
16
Show member pathways
12.28 TSC2 TP53 PTEN IGF1 AKT1
17 12.24 TP53 IGF1 HOXA10 HMGA2
18
Show member pathways
12.2 TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
19 12.17 TP53 IGF1 ESR1 CTNNB1 AKT1
20 12.12 TSC2 TP53 PTEN AKT1
21
Show member pathways
12.1 TSC2 TP53 IGF1 AKT1
22 11.9 TP53 PTEN CTNNB1 AKT1
23 11.72 MME CTNNB1 AKT1
24 11.72 TSC2 TP53 MED12 ESR1 CTNNB1 AKT1
25 11.71 TSC2 TP53 PTEN AKT1
26 11.7 TP53 PTEN AKT1
27 11.66 TP53 PTEN AKT1
28 11.65 GNRH1 ESR2 AKT1
29 11.56 TP53 PTEN AKT1
30 11.54 TSC2 CTNNB1 AKT1
31 11.48 TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
32 11.47 TP53 PTEN AKT1
33 11.41 TSC2 TP53 ESR1
34 11.35 TSC2 TP53 PTEN ESR1 CYP19A1 CTNNB1
35 11.34 TP53 PTEN ESR1
36 11.25 PGR ESR2 CYP19A1
37 11.23 PTEN IGF1 AKT1
38 11.2 TSC2 PTEN AKT1
39 11.13 TSC2 CYP19A1 AKT1
40 11.1 ESR2 ESR1 AKT1
41 10.15 ESR2 ESR1 CYP19A1

GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 TSC2 TP53 PTEN GNRH1 CTNNB1
2 negative regulation of apoptotic process GO:0043066 9.98 TP53 PTEN IGF1 HMGA2 GNRH1 CTNNB1
3 positive regulation of apoptotic process GO:0043065 9.97 TP53 PTEN HMGA2 CTNNB1 AKT1
4 cell-cell signaling GO:0007267 9.91 PGR GNRH1 ESR2 AMH
5 heart development GO:0007507 9.91 TSC2 TP53 PTEN MED12 CTNNB1
6 aging GO:0007568 9.89 PTEN MME GNRH1 AMH AKT1
7 transcription initiation from RNA polymerase II promoter GO:0006367 9.88 PTEN PGR MED12 ESR2 ESR1
8 negative regulation of gene expression GO:0010629 9.88 TP53 PGR IGF1 ESR1 CTNNB1 AKT1
9 positive regulation of gene expression GO:0010628 9.87 TP53 PTEN IGF1 HMGA2 CTNNB1 AMH
10 positive regulation of transcription, DNA-templated GO:0045893 9.86 TP53 MED12 IGF1 HMGA2 ESR2 ESR1
11 response to estradiol GO:0032355 9.83 PTEN ESR1 CYP19A1 CTNNB1
12 protein import into nucleus GO:0006606 9.81 TSC2 TP53 AKT1
13 canonical Wnt signaling pathway GO:0060070 9.77 PTEN MED12 CTNNB1
14 negative regulation of protein kinase B signaling GO:0051898 9.76 TSC2 PTEN AKT1
15 embryonic organ development GO:0048568 9.72 TP53 MED12 CTNNB1
16 phosphatidylinositol 3-kinase signaling GO:0014065 9.71 PTEN IGF1 AKT1
17 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.63 TP53 ESR1
18 insulin-like growth factor receptor signaling pathway GO:0048009 9.63 TSC2 IGF1 AKT1
19 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.62 TP53 ESR1
20 anoikis GO:0043276 9.62 TSC2 AKT1
21 negative regulation of cell size GO:0045792 9.61 PTEN AKT1
22 negative regulation of mitophagy GO:1901525 9.57 TSC2 TP53
23 cellular response to decreased oxygen levels GO:0036294 9.56 PTEN AKT1
24 intracellular steroid hormone receptor signaling pathway GO:0030518 9.54 PGR ESR2 ESR1
25 protein kinase B signaling GO:0043491 9.46 TSC2 PTEN IGF1 AKT1
26 positive regulation of DNA-binding transcription factor activity GO:0051091 9.35 PTEN ESR2 ESR1 CTNNB1 AKT1
27 positive regulation of transcription by RNA polymerase II GO:0045944 9.32 TP53 PGR MED12 IGF1 HOXA10 HMGA2

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.85 TP53 PTEN ESR1 CTNNB1 AKT1
2 transcription factor binding GO:0008134 9.72 TP53 MED12 HMGA2 ESR1 CTNNB1
3 nuclear receptor activity GO:0004879 9.58 PGR ESR2 ESR1
4 nitric-oxide synthase regulator activity GO:0030235 9.43 ESR1 AKT1
5 estrogen receptor activity GO:0030284 9.37 ESR2 ESR1
6 steroid binding GO:0005496 9.33 PGR ESR2 ESR1
7 estrogen response element binding GO:0034056 9.26 ESR2 ESR1
8 enzyme binding GO:0019899 9.17 TP53 PTEN PGR ESR2 ESR1 CTNNB1
9 steroid hormone receptor activity GO:0003707 9.13 PGR ESR2 ESR1

Sources for Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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