Reproductive Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RPR001 MIFTS: 29	Reproductive Organ Benign Neoplasm Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050622

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Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to cervical benign neoplasm and vestibular gland benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include reproductive system, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

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Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)

#	Related Disease	Score	Top Affiliating Genes
1	cervical benign neoplasm	32.6	PGR MME
2	vestibular gland benign neoplasm	32.6	TP53 PGR ESR1
3	ovarian benign neoplasm	32.6	TP53 EPPIN AMH
4	vaginal benign neoplasm	32.5	ESR2 CYP19A1 CTNNB1
5	fallopian tube benign neoplasm	32.5	TSC2 MME CALD1
6	vulvar benign neoplasm	32.4	PGR MME HMGA2 ESR1 CALD1
7	uterine benign neoplasm	30.9	TSC2 TP53 PTEN PGR MME MED12
8	male reproductive organ benign neoplasm	11.7
9	sex cord-stromal benign neoplasm	11.2
10	paratesticular lipoma	11.2
11	wolffian duct adenoma	11.2
12	prostatic adenoma	11.2
13	prostate leiomyoma	11.2
14	dartoic leiomyoma	11.2
15	rete testis adenoma	11.2
16	epididymis adenomatoid tumor	11.2
17	breast duct papilloma	10.5	PTEN PGR
18	glassy cell carcinoma of the cervix	10.5	PGR ESR1
19	breast intraductal papillomatosis	10.5	PGR ESR1
20	nipple carcinoma	10.5	PGR ESR1
21	bartholin's gland adenoid cystic carcinoma	10.5	PGR ESR1
22	chronic tympanitis	10.5	PGR ESR1
23	granulomatous endometritis	10.5	PGR ESR1
24	vulvar syringoma	10.5	PGR ESR1
25	isolated anorectal malformation	10.5	MED12 CTNNB1
26	cervical adenomyoma	10.5	PGR MME
27	nonmucinous bronchioloalveolar adenocarcinoma	10.5	ESR2 ESR1
28	vaginitis	10.5	ESR2 ESR1 EPPIN
29	bartholin's gland adenoma	10.5	TP53 PGR ESR1
30	bartholin's gland benign neoplasm	10.5	TP53 PGR ESR1
31	breast leiomyoma	10.5	PGR MME
32	fallopian tube endometriosis	10.5	PGR MME
33	liver adenomatosis	10.5	PGR CTNNB1
34	mucinous adenocarcinoma	10.5	TP53 PGR ESR1
35	ovarian seromucinous carcinoma	10.5	TP53 PGR ESR1
36	pulmonary vein leiomyosarcoma	10.5	PGR CALD1
37	adult type testicular granulosa cell tumor	10.5	PGR ESR1
38	pregnancy adenoma	10.5	PGR MED12
39	breast scirrhous carcinoma	10.5	PGR ESR1
40	comedo carcinoma	10.5	TP53 PGR ESR1
41	lung leiomyoma	10.5	PGR ESR1 CALD1
42	basaloid lung carcinoma	10.5	TP53 PGR
43	oncocytic breast carcinoma	10.5	PGR ESR1
44	cervical clear cell adenocarcinoma	10.5	PGR ESR1
45	vaginal endometrial stromal tumor	10.5	MME CALD1
46	progesterone resistance	10.5	PGR ESR2 ESR1
47	uterine corpus adenosarcoma	10.5	PGR MME ESR1
48	juvenile nasopharyngeal angiofibroma	10.5	PGR ESR1 CYP19A1
49	atrophy of prostate	10.5	TP53 GNRH1 EPPIN
50	subserous uterine fibroid	10.5	PGR CYP19A1 AMH

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:

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Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased TP53 mRNA expression	GR00389-S-5	9.26	TP53
2	Decreased TP53 mRNA expression	GR00389-S-6	9.26	ESR2 HMGA2 TP53
3	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	8.92	ESR1 ESR2 FH PTEN

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.4	AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
2	cardiovascular system	MP:0005385	10.36	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 HOXA10
3	cellular	MP:0005384	10.35	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 FH
4	endocrine/exocrine gland	MP:0005379	10.32	AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
5	integument	MP:0010771	10.29	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
6	digestive/alimentary	MP:0005381	10.13	CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
7	liver/biliary system	MP:0005370	10.13	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
8	nervous system	MP:0003631	10.13	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
9	limbs/digits/tail	MP:0005371	10.11	CTNNB1 ESR1 ESR2 HOXA10 IGF1 MED12
10	neoplasm	MP:0002006	10.11	AKT1 AMH CTNNB1 ESR1 ESR2 GNRH1
11	muscle	MP:0005369	10.06	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 IGF1
12	normal	MP:0002873	10.03	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
13	renal/urinary system	MP:0005367	9.85	CTNNB1 CYP19A1 ESR1 ESR2 FH GNRH1
14	reproductive system	MP:0005389	9.77	AKT1 AMH CTNNB1 CYP19A1 ESR1 ESR2
15	skeleton	MP:0005390	9.4	AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1

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Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

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Genetic Tests for Reproductive Organ Benign Neoplasm

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Anatomical Context for Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

¹⁹

Reproductive System

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Publications for Reproductive Organ Benign Neoplasm

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Genes for Reproductive Organ Benign Neoplasm

Genes related to Reproductive Organ Benign Neoplasm (0 elite genes):

(show all 40)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	8.53	DISEASES inferred ¹⁵
2	MED12	Mediator Complex Subunit 12	Protein Coding	8.38	DISEASES inferred ¹⁵
3	ESR1	Estrogen Receptor 1	Protein Coding	8.01	DISEASES inferred ¹⁵
4	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	7.96	DISEASES inferred ¹⁵ ¹⁵
5	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	7.84	DISEASES inferred ¹⁵
6	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	7.67	DISEASES inferred ¹⁵
7	FH	Fumarate Hydratase	Protein Coding	7.63	DISEASES inferred ¹⁵
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	7.37	DISEASES inferred ¹⁵
9	ESR2	Estrogen Receptor 2	Protein Coding	7.15	DISEASES inferred ¹⁵
10	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	7.12	DISEASES inferred ¹⁵
11	TP53	Tumor Protein P53	Protein Coding	7.09	DISEASES inferred ¹⁵
12	AMH	Anti-Mullerian Hormone	Protein Coding	6.97	DISEASES inferred ¹⁵
13	CALD1	Caldesmon 1	Protein Coding	6.75	DISEASES inferred ¹⁵
14	SERPINA3	Serpin Family A Member 3	Protein Coding	6.74	DISEASES inferred ¹⁵ ¹⁵
15	CTNNB1	Catenin Beta 1	Protein Coding	6.71	DISEASES inferred ¹⁵
16	HOXA10	Homeobox A10	Protein Coding	6.7	DISEASES inferred ¹⁵
17	MME	Membrane Metalloendopeptidase	Protein Coding	6.69	DISEASES inferred ¹⁵
18	IGF1	Insulin Like Growth Factor 1	Protein Coding	6.64	DISEASES inferred ¹⁵
19	TSC2	TSC Complex Subunit 2	Protein Coding	6.6	DISEASES inferred ¹⁵
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.59	DISEASES inferred ¹⁵
21	H2AC18	H2A Clustered Histone 18	Protein Coding	6.59	DISEASES inferred ¹⁵ ¹⁵
22	JAZF1	JAZF Zinc Finger 1	Protein Coding	6.47	DISEASES inferred ¹⁵
23	SHBG	Sex Hormone Binding Globulin	Protein Coding	6.47	DISEASES inferred ¹⁵
24	RAD51B	RAD51 Paralog B	Protein Coding	6.44	DISEASES inferred ¹⁵
25	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.42	DISEASES inferred ¹⁵
26	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.42	DISEASES inferred ¹⁵
27	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	6.41	DISEASES inferred ¹⁵
28	BET1L	Bet1 Golgi Vesicular Membrane Trafficking Protein Like	Protein Coding	6.41	DISEASES inferred ¹⁵
29	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	6.37	DISEASES inferred ¹⁵
30	PRL	Prolactin	Protein Coding	6.35	DISEASES inferred ¹⁵
31	CALB2	Calbindin 2	Protein Coding	6.35	DISEASES inferred ¹⁵
32	CCND1	Cyclin D1	Protein Coding	6.34	DISEASES inferred ¹⁵
33	CD34	CD34 Molecule	Protein Coding	6.34	DISEASES inferred ¹⁵
34	CDK8	Cyclin Dependent Kinase 8	Protein Coding	6.3	DISEASES inferred ¹⁵
35	KRT7	Keratin 7	Protein Coding	6.2	DISEASES inferred ¹⁵
36	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.2	DISEASES inferred ¹⁵
37	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	6.18	DISEASES inferred ¹⁵
38	AFP	Alpha Fetoprotein	Protein Coding	6.18	DISEASES inferred ¹⁵
39	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.16	DISEASES inferred ¹⁵
40	CCNC	Cyclin C	Protein Coding	6.15	DISEASES inferred ¹⁵

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Variations for Reproductive Organ Benign Neoplasm

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Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

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Pathways for Reproductive Organ Benign Neoplasm

Pathways related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 41)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.81	TSC2 TP53 PTEN IGF1 GNRH1 ESR2
2	Nanog in Mammalian ESC Pluripotency ⁶³ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶³ eNOS Signaling ⁶³ GSK3 Signaling ⁶³	13.25	TSC2 IGF1 GNRH1 ESR2 ESR1 CTNNB1
3	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.95	TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.81	TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
5	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.69	TP53 PTEN ESR1 CTNNB1 AKT1
6	Pathways in cancer ³⁶	12.65	TP53 PTEN IGF1 FH ESR2 ESR1
7	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.64	PGR IGF1 ESR2 ESR1 AKT1
8	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.59	TP53 PTEN IGF1 FH AKT1
9	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.59	TSC2 IGF1 GNRH1 CTNNB1 AKT1
10	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.58	TSC2 TP53 PTEN IGF1 ESR2 ESR1
11	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.53	TP53 PTEN PGR IGF1 ESR2 ESR1
12	Glucose / Energy Metabolism ⁴	12.48	TSC2 PTEN FH CYP19A1 AKT1
13	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.44	TSC2 TP53 PTEN IGF1 AKT1
14	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.35	TSC2 TP53 PTEN IGF1
15	Development Ligand-independent activation of ESR1 and ESR2 ²³ Show member pathways Transcription CREB pathway ²³ Transcription PPAR Pathway ²³	12.3	IGF1 ESR2 ESR1 AKT1
16	Development IGF-1 receptor signaling ²³ Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²³ Signal transduction AKT signaling ²³	12.28	TSC2 TP53 PTEN IGF1 AKT1
17	Transcriptional misregulation in cancer ³⁶	12.24	TP53 IGF1 HOXA10 HMGA2
18	Translation Non-genomic (rapid) action of Androgen Receptor ²³ Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²³	12.2	TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
19	Proteoglycans in cancer ³⁶	12.17	TP53 IGF1 ESR1 CTNNB1 AKT1
20	Cellular senescence (KEGG) ³⁶	12.12	TSC2 TP53 PTEN AKT1
21	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	12.1	TSC2 TP53 IGF1 AKT1
22	DNA Damage Response (only ATM dependent) ¹	11.9	TP53 PTEN CTNNB1 AKT1
23	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.72	MME CTNNB1 AKT1
24	Thyroid hormone signaling pathway ³⁶	11.72	TSC2 TP53 MED12 ESR1 CTNNB1 AKT1
25	TP53 Regulates Metabolic Genes ⁶⁵	11.71	TSC2 TP53 PTEN AKT1
26	Central carbon metabolism in cancer ³⁶	11.7	TP53 PTEN AKT1
27	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.66	TP53 PTEN AKT1
28	GnRH secretion ³⁶	11.65	GNRH1 ESR2 AKT1
29	Copper homeostasis ¹	11.56	TP53 PTEN AKT1
30	Wnt Signaling Pathway Netpath ¹	11.54	TSC2 CTNNB1 AKT1
31	Glioblastoma Multiforme ⁶³	11.48	TSC2 TP53 PTEN IGF1 CTNNB1 AKT1
32	Integrated Cancer Pathway ¹	11.47	TP53 PTEN AKT1
33	LKB1 signaling events ¹	11.41	TSC2 TP53 ESR1
34	Integrated Breast Cancer Pathway ¹	11.35	TSC2 TP53 PTEN ESR1 CYP19A1 CTNNB1
35	Ovarian tumor domain proteases ⁶⁵	11.34	TP53 PTEN ESR1
36	Ovarian Infertility Genes ¹	11.25	PGR ESR2 CYP19A1
37	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling ¹	11.23	PTEN IGF1 AKT1
38	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.2	TSC2 PTEN AKT1
39	Follicle Stimulating Hormone (FSH) signaling pathway ¹	11.13	TSC2 CYP19A1 AKT1
40	Plasma membrane estrogen receptor signaling ¹	11.1	ESR2 ESR1 AKT1
41	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	10.15	ESR2 ESR1 CYP19A1

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GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.99	TSC2 TP53 PTEN GNRH1 CTNNB1
2	negative regulation of apoptotic process	GO:0043066	9.98	TP53 PTEN IGF1 HMGA2 GNRH1 CTNNB1
3	positive regulation of apoptotic process	GO:0043065	9.97	TP53 PTEN HMGA2 CTNNB1 AKT1
4	cell-cell signaling	GO:0007267	9.91	PGR GNRH1 ESR2 AMH
5	heart development	GO:0007507	9.91	TSC2 TP53 PTEN MED12 CTNNB1
6	aging	GO:0007568	9.89	PTEN MME GNRH1 AMH AKT1
7	transcription initiation from RNA polymerase II promoter	GO:0006367	9.88	PTEN PGR MED12 ESR2 ESR1
8	negative regulation of gene expression	GO:0010629	9.88	TP53 PGR IGF1 ESR1 CTNNB1 AKT1
9	positive regulation of gene expression	GO:0010628	9.87	TP53 PTEN IGF1 HMGA2 CTNNB1 AMH
10	positive regulation of transcription, DNA-templated	GO:0045893	9.86	TP53 MED12 IGF1 HMGA2 ESR2 ESR1
11	response to estradiol	GO:0032355	9.83	PTEN ESR1 CYP19A1 CTNNB1
12	protein import into nucleus	GO:0006606	9.81	TSC2 TP53 AKT1
13	canonical Wnt signaling pathway	GO:0060070	9.77	PTEN MED12 CTNNB1
14	negative regulation of protein kinase B signaling	GO:0051898	9.76	TSC2 PTEN AKT1
15	embryonic organ development	GO:0048568	9.72	TP53 MED12 CTNNB1
16	phosphatidylinositol 3-kinase signaling	GO:0014065	9.71	PTEN IGF1 AKT1
17	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903799	9.63	TP53 ESR1
18	insulin-like growth factor receptor signaling pathway	GO:0048009	9.63	TSC2 IGF1 AKT1
19	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.62	TP53 ESR1
20	anoikis	GO:0043276	9.62	TSC2 AKT1
21	negative regulation of cell size	GO:0045792	9.61	PTEN AKT1
22	negative regulation of mitophagy	GO:1901525	9.57	TSC2 TP53
23	cellular response to decreased oxygen levels	GO:0036294	9.56	PTEN AKT1
24	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.54	PGR ESR2 ESR1
25	protein kinase B signaling	GO:0043491	9.46	TSC2 PTEN IGF1 AKT1
26	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.35	PTEN ESR2 ESR1 CTNNB1 AKT1
27	positive regulation of transcription by RNA polymerase II	GO:0045944	9.32	TP53 PGR MED12 IGF1 HOXA10 HMGA2

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.85	TP53 PTEN ESR1 CTNNB1 AKT1
2	transcription factor binding	GO:0008134	9.72	TP53 MED12 HMGA2 ESR1 CTNNB1
3	nuclear receptor activity	GO:0004879	9.58	PGR ESR2 ESR1
4	nitric-oxide synthase regulator activity	GO:0030235	9.43	ESR1 AKT1
5	estrogen receptor activity	GO:0030284	9.37	ESR2 ESR1
6	steroid binding	GO:0005496	9.33	PGR ESR2 ESR1
7	estrogen response element binding	GO:0034056	9.26	ESR2 ESR1
8	enzyme binding	GO:0019899	9.17	TP53 PTEN PGR ESR2 ESR1 CTNNB1
9	steroid hormone receptor activity	GO:0003707	9.13	PGR ESR2 ESR1

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Sources for Reproductive Organ Benign Neoplasm

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