MCID: RPR001
MIFTS: 27

Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050622

Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to male reproductive organ benign neoplasm and vestibular gland benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Th1 Differentiation Pathway and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include lung, ovary and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 male reproductive organ benign neoplasm 34.0 AFP CYP19A1 DICER1
2 vestibular gland benign neoplasm 32.2 ESR1 PGR
3 vulvar benign neoplasm 32.2 ESR1 PGR
4 ovarian benign neoplasm 32.1 CYP19A1 FH
5 uterine benign neoplasm 29.6 CD3E ESR1 FH GNRH1 HMGA2 HPSE2
6 cervical benign neoplasm 11.2
7 fallopian tube benign neoplasm 11.2
8 vaginal benign neoplasm 11.2
9 bartholin's gland adenoma 10.3 ESR1 PGR
10 bizarre leiomyoma 10.3 MED12 PGR
11 vulvar syringoma 10.3 ESR1 PGR
12 pleomorphic lipoma 10.3 HMGA2 PGR
13 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
14 lung leiomyoma 10.3 ESR1 PGR
15 trigonitis 10.3 ESR1 PGR
16 vulvar leiomyoma 10.3 ESR1 PGR
17 mixed hepatoblastoma 10.3 AFP PGR
18 breast medullary carcinoma 10.3 ESR1 PGR
19 breast scirrhous carcinoma 10.3 ESR1 PGR
20 bartholin's gland benign neoplasm 10.3 ESR1 PGR
21 oncocytic breast carcinoma 10.2 ESR1 PGR
22 progesterone resistance 10.2 ESR1 PGR
23 endometrial squamous cell carcinoma 10.2 ESR1 PGR
24 cribriform carcinoma 10.2 ESR1 PGR
25 testicular granulosa cell tumor 10.2 AFP DICER1
26 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
27 juvenile type testicular granulosa cell tumor 10.2 AFP DICER1
28 adenoid basal cell carcinoma 10.2 ESR1 PGR
29 breast adenoid cystic carcinoma 10.2 ESR1 PGR
30 apocrine adenocarcinoma 10.2 ESR1 PGR
31 cystic nephroma 10.2 DICER1 PGR
32 deep angioma 10.2 ESR1 PGR
33 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
34 benign metastasizing leiomyoma 10.2 CYP19A1 PGR
35 breast benign neoplasm 10.2 ESR1 MED12 PGR
36 thoracic benign neoplasm 10.2 ESR1 MED12 PGR
37 female reproductive endometrioid cancer 10.2 ESR1 PGR
38 cervical carcinosarcoma 10.2 ESR1 PGR
39 scrotal carcinoma 10.2 AFP HMGA2
40 smooth muscle tumor 10.2 ESR1 HMGA2 PGR
41 intramuscular hemangioma 10.2 ESR1 PGR
42 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
43 leiomyosarcoma 10.2 FH MED12 PGR
44 gynandroblastoma 10.2 CALB2 DICER1
45 tubular adenocarcinoma 10.2 AFP ESR1 PGR
46 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
47 progesterone-receptor positive breast cancer 10.1 CYP19A1 ESR1 PGR
48 gender identity disorder 10.1 CYP19A1 ESR1 PGR
49 estrogen excess 10.1 CYP19A1 ESR1 PGR
50 mammographic density 10.1 CYP19A1 ESR1 PGR

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:



Diseases related to Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.62 DICER1 MED12 PRDM10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 MED12
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.62 MED12
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.62 MED12
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.62 PRDM10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.62 PRDM10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 DICER1 MED12
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.62 MED12
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.62 PRDM10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.62 MED12
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.62 DICER1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.62 MED12
13 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.62 DICER1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.62 DICER1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.62 MED12
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 DICER1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.62 MED12

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.07 AFP CD3E DICER1 ESR1 FH HPSE2
2 neoplasm MP:0002006 9.63 AFP CD3E DICER1 ESR1 GNRH1 PGR
3 normal MP:0002873 9.56 CALB2 CYP19A1 DICER1 ESR1 GNRH1 MED12
4 renal/urinary system MP:0005367 9.17 CYP19A1 DICER1 ESR1 FH GNRH1 HPSE2

Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

Genetic Tests for Reproductive Organ Benign Neoplasm

Anatomical Context for Reproductive Organ Benign Neoplasm

MalaCards organs/tissues related to Reproductive Organ Benign Neoplasm:

41
Lung, Ovary, Prostate, Cervix, Testis, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

19
Reproductive System Organs

Publications for Reproductive Organ Benign Neoplasm

Variations for Reproductive Organ Benign Neoplasm

Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

Pathways for Reproductive Organ Benign Neoplasm

Pathways related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CD3E TGFB3 TLR9
2 9.23 CYP19A1 ESR1

GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 ESR1 HMGA2 MED12 PGR TGFB3 TLR9
2 negative regulation of gene expression GO:0010629 9.56 CD3E ESR1 PGR TNRC6B
3 uterus development GO:0060065 9.4 CYP19A1 ESR1
4 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 ESR1 MED12
6 ovulation from ovarian follicle GO:0001542 9.16 AFP PGR
7 embryonic neurocranium morphogenesis GO:0048702 8.96 MED12 TGFB3
8 mammary gland development GO:0030879 8.8 CYP19A1 PGR TGFB3

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 siRNA binding GO:0035197 8.62 DICER1 TLR9

Sources for Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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