MCID: RPR001
MIFTS: 28

Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050622

Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to cervical benign neoplasm and vestibular gland benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include reproductive system, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 cervical benign neoplasm 33.1 PGR MME
2 vestibular gland benign neoplasm 33.1 TP53 PGR ESR1
3 vulvar benign neoplasm 33.0 PGR CALD1
4 vaginal benign neoplasm 33.0 ESR2 CYP19A1 CTNNB1
5 fallopian tube benign neoplasm 32.9 TSC2 MME CALD1
6 ovarian benign neoplasm 32.9 TP53 GNRH1 EPPIN AMH
7 uterine benign neoplasm 30.9 TSC2 TP53 PTEN PGR MME MED12
8 male reproductive organ benign neoplasm 12.9
9 wolffian duct adenoma 11.4
10 prostatic adenoma 11.4
11 prostate leiomyoma 11.4
12 dartoic leiomyoma 11.4
13 rete testis adenoma 11.4
14 epididymis adenomatoid tumor 11.4
15 glassy cell carcinoma of the cervix 10.7 PGR ESR1
16 bartholin's gland adenoid cystic carcinoma 10.7 PGR ESR1
17 infertility due to extratesticular cause 10.7 GNRH1 ESR1
18 chronic tympanitis 10.7 PGR ESR1
19 granulomatous endometritis 10.7 PGR ESR1
20 cervical adenomyoma 10.7 PGR MME
21 breast duct papilloma 10.7 PTEN PGR
22 vaginal glandular tumor 10.7 PGR ESR1
23 fallopian tube endometriosis 10.7 PGR MME
24 vulvar syringoma 10.7 PGR ESR1
25 trigonitis 10.7 PGR ESR1
26 fat necrosis of breast 10.7 HMGA2 ESR1
27 liver adenomatosis 10.7 PGR CTNNB1
28 breast scirrhous carcinoma 10.7 PGR ESR1
29 nonmucinous bronchioloalveolar adenocarcinoma 10.7 ESR2 ESR1
30 vaginitis 10.7 ESR2 ESR1 EPPIN
31 oncocytic breast carcinoma 10.7 PGR ESR1
32 bartholin's gland adenoma 10.7 TP53 PGR ESR1
33 endometrial squamous cell carcinoma 10.7 TP53 PGR
34 bartholin's gland benign neoplasm 10.7 TP53 PGR ESR1
35 cervical clear cell adenocarcinoma 10.7 PGR ESR1
36 pulmonary vein leiomyosarcoma 10.7 PGR CALD1
37 cecum lymphoma 10.7 TP53 MME
38 ovarian seromucinous carcinoma 10.7 TP53 PGR ESR1
39 cervical serous adenocarcinoma 10.7 PGR MME
40 comedo carcinoma 10.7 TP53 PGR ESR1
41 breast leiomyoma 10.7 PGR MME FH
42 uterine corpus adenosarcoma 10.7 PGR MME ESR1
43 mixed endometrial stromal and smooth muscle tumor 10.7 MME CALD1
44 adult type testicular granulosa cell tumor 10.7 PGR ESR1
45 vaginal endometrial stromal tumor 10.7 MME CALD1
46 urethra leiomyoma 10.7 MME CALD1
47 lung leiomyoma 10.7 PGR ESR1 CALD1
48 progesterone resistance 10.7 PGR ESR2 ESR1
49 juvenile nasopharyngeal angiofibroma 10.7 PGR ESR1 CYP19A1
50 breast metaplastic carcinoma 10.7 PGR MME ESR1

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:



Diseases related to Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 9.26 TP53
2 Decreased TP53 mRNA expression GR00389-S-6 9.26 ESR2 HMGA2 TP53
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 ESR2 FH PTEN

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 AMH CTNNB1 CYP19A1 ESR1 ESR2 FH
2 behavior/neurological MP:0005386 10.35 CTNNB1 CYP19A1 ESR1 ESR2 HOXA10 HPSE2
3 cellular MP:0005384 10.33 CTNNB1 CYP19A1 ESR1 ESR2 FH IGF1
4 cardiovascular system MP:0005385 10.3 CTNNB1 CYP19A1 ESR1 ESR2 HOXA10 IGF1
5 endocrine/exocrine gland MP:0005379 10.3 AMH CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
6 growth/size/body region MP:0005378 10.29 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
7 integument MP:0010771 10.26 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 IGF1
8 digestive/alimentary MP:0005381 10.19 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
9 adipose tissue MP:0005375 10.12 CYP19A1 ESR1 ESR2 HOXA10 IGF1 PTEN
10 limbs/digits/tail MP:0005371 10.11 CTNNB1 ESR1 ESR2 HOXA10 IGF1 MED12
11 nervous system MP:0003631 10.1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
12 liver/biliary system MP:0005370 10.09 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 MME
13 neoplasm MP:0002006 10.07 AMH CTNNB1 ESR1 ESR2 GNRH1 IGF1
14 muscle MP:0005369 10.01 CTNNB1 CYP19A1 ESR1 ESR2 IGF1 PGR
15 normal MP:0002873 10 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 IGF1
16 renal/urinary system MP:0005367 9.9 CTNNB1 CYP19A1 ESR1 ESR2 FH GNRH1
17 reproductive system MP:0005389 9.73 AMH CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
18 skeleton MP:0005390 9.36 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10

Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

Genetic Tests for Reproductive Organ Benign Neoplasm

Anatomical Context for Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

19
Reproductive System

Publications for Reproductive Organ Benign Neoplasm

Variations for Reproductive Organ Benign Neoplasm

Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

Pathways for Reproductive Organ Benign Neoplasm

Pathways related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.64 TP53 PTEN IGF1 FH ESR2 ESR1
2
Show member pathways
12.53 TP53 PTEN PGR IGF1 ESR2 ESR1
3
Show member pathways
12.48 TSC2 TP53 PTEN IGF1 ESR2 ESR1
4
Show member pathways
12.23 TSC2 TP53 PTEN IGF1
5
Show member pathways
12.21 TSC2 TP53 PTEN IGF1
6
Show member pathways
12.17 TSC2 TP53 PTEN IGF1 CTNNB1
7 12.14 TP53 IGF1 HPSE2 ESR1 CTNNB1
8 12.11 TP53 IGF1 HOXA10 HMGA2
9 11.74 TSC2 TP53 MED12 ESR1 CTNNB1
10
Show member pathways
11.7 PGR ESR2 ESR1
11 11.66 TSC2 TP53 PTEN
12 11.6 TSC2 TP53 PTEN IGF1 CTNNB1
13 11.31 TSC2 TP53 ESR1
14 11.29 TSC2 TP53 PTEN ESR1 CYP19A1 CTNNB1
15 11.24 TP53 PTEN ESR1
16 11.16 PGR ESR2 CYP19A1
17 9.73 ESR2 ESR1 CYP19A1

GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 TP53 PGR MED12 IGF1 HOXA10 HMGA2
2 negative regulation of cell proliferation GO:0008285 9.95 TSC2 TP53 PTEN GNRH1 CTNNB1
3 negative regulation of apoptotic process GO:0043066 9.93 TP53 PTEN IGF1 HMGA2 GNRH1 CTNNB1
4 cell-cell signaling GO:0007267 9.88 PGR GNRH1 ESR2 AMH
5 negative regulation of gene expression GO:0010629 9.88 TP53 PGR IGF1 ESR1 CTNNB1
6 aging GO:0007568 9.83 PTEN MME GNRH1 AMH
7 positive regulation of gene expression GO:0010628 9.8 TP53 PTEN IGF1 HMGA2 CTNNB1 AMH
8 canonical Wnt signaling pathway GO:0060070 9.73 PTEN MED12 CTNNB1
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 PTEN ESR2 ESR1 CTNNB1
10 response to estradiol GO:0032355 9.71 PTEN ESR1 CYP19A1 CTNNB1
11 positive regulation of transcription, DNA-templated GO:0045893 9.7 TP53 MED12 IGF1 HMGA2 ESR2 ESR1
12 protein kinase B signaling GO:0043491 9.67 TSC2 PTEN IGF1
13 heart development GO:0007507 9.65 TSC2 TP53 PTEN MED12 CTNNB1
14 replicative senescence GO:0090399 9.59 TP53 MME
15 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.58 TP53 ESR1
16 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.57 TP53 ESR1
17 prostate gland growth GO:0060736 9.54 PTEN CYP19A1
18 negative regulation of mitophagy GO:1901525 9.51 TSC2 TP53
19 uterus development GO:0060065 9.13 HOXA10 ESR1 CYP19A1
20 transcription initiation from RNA polymerase II promoter GO:0006367 9.02 PTEN PGR MED12 ESR2 ESR1

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.88 TP53 PGR HOXA10 HMGA2 ESR1
2 transcription factor binding GO:0008134 9.83 TP53 MED12 HMGA2 ESR1 CTNNB1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 TP53 PGR MED12 HOXA10 HMGA2 ESR2
4 beta-catenin binding GO:0008013 9.67 MED12 ESR1 CTNNB1
5 steroid hormone receptor activity GO:0003707 9.63 PGR ESR2 ESR1
6 nuclear receptor activity GO:0004879 9.54 PGR ESR2 ESR1
7 steroid binding GO:0005496 9.43 PGR ESR2 ESR1
8 enzyme binding GO:0019899 9.43 TP53 PTEN PGR ESR2 ESR1 CTNNB1
9 estrogen receptor activity GO:0030284 9.4 ESR2 ESR1
10 estrogen response element binding GO:0034056 9.32 ESR2 ESR1
11 repressing transcription factor binding GO:0070491 8.92 PGR ESR2 ESR1 CTNNB1

Sources for Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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