MCID: RPR001
MIFTS: 29

Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Reproductive Organ Benign Neoplasm:

Name: Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050622

Summaries for Reproductive Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in reproductive system organs.

MalaCards based summary : Reproductive Organ Benign Neoplasm is related to vestibular gland benign neoplasm and vulvar benign neoplasm. An important gene associated with Reproductive Organ Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include reproductive system, breast and prostate, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

Related Diseases for Reproductive Organ Benign Neoplasm

Diseases related to Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 vestibular gland benign neoplasm 33.0 TP53 PGR ESR1
2 vulvar benign neoplasm 33.0 PGR HMGA2 ESR1
3 ovarian benign neoplasm 33.0 TP53 GNRH1 EPPIN
4 fallopian tube benign neoplasm 33.0 TSC2 MME
5 uterine benign neoplasm 30.7 TSC2 TP53 PTEN PGR MME MIR18A
6 male reproductive organ benign neoplasm 12.9
7 cervical benign neoplasm 11.4
8 vaginal benign neoplasm 11.4
9 wolffian duct adenoma 11.4
10 prostatic adenoma 11.4
11 prostate leiomyoma 11.4
12 dartoic leiomyoma 11.4
13 epididymis adenomatoid tumor 11.4
14 glassy cell carcinoma of the cervix 10.7 PGR ESR1
15 bartholin's gland adenoid cystic carcinoma 10.7 PGR ESR1
16 chronic tympanitis 10.7 PGR ESR1
17 infertility due to extratesticular cause 10.7 GNRH1 ESR1
18 granulomatous endometritis 10.7 PGR ESR1
19 cervical adenomyoma 10.7 PGR MME
20 subserous uterine fibroid 10.7 PGR AMH
21 breast juvenile papillomatosis 10.7 PGR ESR1
22 lung leiomyoma 10.7 PGR ESR1
23 vulvar syringoma 10.7 PGR ESR1
24 trigonitis 10.7 PGR ESR1
25 diffuse peritoneal leiomyomatosis 10.7 PGR MED12 FH
26 peritoneal benign neoplasm 10.7 PGR MED12 FH
27 breast duct papilloma 10.7 PTEN PGR
28 breast scirrhous carcinoma 10.7 PGR ESR1
29 oncocytic breast carcinoma 10.7 PGR ESR1
30 vagina leiomyosarcoma 10.7 PGR ESR1
31 mucinous adenocarcinoma 10.7 TP53 PGR ESR1
32 adult type testicular granulosa cell tumor 10.7 PGR ESR1
33 breast myofibroblastoma 10.7 MME ESR1
34 bartholin's gland adenoma 10.7 TP53 PGR ESR1
35 bartholin's gland benign neoplasm 10.7 TP53 PGR ESR1
36 breast papillary carcinoma 10.7 PGR ESR1
37 vulvar leiomyoma 10.7 PGR HMGA2 ESR1
38 ovarian seromucinous carcinoma 10.7 TP53 PGR ESR1
39 breast neuroendocrine neoplasm 10.7 PGR GNRH1 ESR1
40 mammographic density 10.7 PGR ESR1 CYP19A1
41 comedo carcinoma 10.7 TP53 PGR ESR1
42 nonmucinous bronchioloalveolar adenocarcinoma 10.7 ESR2 ESR1
43 cervical serous adenocarcinoma 10.7 PGR MME
44 atrophy of prostate 10.7 TP53 GNRH1 EPPIN
45 postmenopausal atrophic vaginitis 10.7 GNRH1 ESR1 CYP19A1
46 endosalpingiosis 10.7 TP53 PGR ESR1
47 juvenile nasopharyngeal angiofibroma 10.7 PGR ESR1 CYP19A1
48 congenital epulis 10.7 SERPINA3 PGR
49 epulis 10.7 SERPINA3 PGR
50 luteoma 10.7 GNRH1 EPPIN CYP19A1

Graphical network of the top 20 diseases related to Reproductive Organ Benign Neoplasm:



Diseases related to Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 ESR1 ESR2 FH PTEN
2 Increased TP53 mRNA expression GR00389-S-6 8.8 ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Reproductive Organ Benign Neoplasm:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.29 AMH CYP19A1 ESR1 ESR2 FH GNRH1
2 cellular MP:0005384 10.26 CYP19A1 ESR1 ESR2 FH MED12 MFN2
3 cardiovascular system MP:0005385 10.24 CYP19A1 ESR1 ESR2 HOXA10 MED12 MFN2
4 endocrine/exocrine gland MP:0005379 10.19 AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
5 digestive/alimentary MP:0005381 10.11 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HPSE2
6 integument MP:0010771 10.11 CYP19A1 ESR1 ESR2 GNRH1 MME PGR
7 nervous system MP:0003631 10.06 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 MED12
8 liver/biliary system MP:0005370 10.01 CYP19A1 ESR1 ESR2 GNRH1 MME PTEN
9 limbs/digits/tail MP:0005371 9.98 ESR1 ESR2 HOXA10 MED12 PGR PTEN
10 neoplasm MP:0002006 9.97 AMH ESR1 ESR2 GNRH1 PGR PTEN
11 normal MP:0002873 9.96 CYP19A1 ESR1 ESR2 GNRH1 MED12 MFN2
12 renal/urinary system MP:0005367 9.81 CYP19A1 ESR1 ESR2 FH GNRH1 HPSE2
13 reproductive system MP:0005389 9.65 AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
14 skeleton MP:0005390 9.32 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 MED12

Drugs & Therapeutics for Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Reproductive Organ Benign Neoplasm

Genetic Tests for Reproductive Organ Benign Neoplasm

Anatomical Context for Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive Organ Benign Neoplasm:

19
Reproductive System

MalaCards organs/tissues related to Reproductive Organ Benign Neoplasm:

40
Breast, Prostate, Skin, Ovary, Tongue, Lung, Heart

Publications for Reproductive Organ Benign Neoplasm

Variations for Reproductive Organ Benign Neoplasm

Expression for Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Reproductive Organ Benign Neoplasm.

Pathways for Reproductive Organ Benign Neoplasm

GO Terms for Reproductive Organ Benign Neoplasm

Biological processes related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 TP53 PTEN MIR146A HMGA2 AMH
2 heart development GO:0007507 9.81 TSC2 TP53 PTEN MED12
3 cell-cell signaling GO:0007267 9.78 PGR GNRH1 ESR2 AMH
4 aging GO:0007568 9.56 PTEN MME GNRH1 AMH
5 negative regulation of protein kinase B signaling GO:0051898 9.54 TSC2 PTEN MIR146A
6 replicative senescence GO:0090399 9.52 TP53 MME
7 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.49 TP53 ESR1
8 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.46 TP53 ESR1
9 regulation of toll-like receptor signaling pathway GO:0034121 9.4 MIR146A ESR1
10 prostate gland growth GO:0060736 9.32 PTEN CYP19A1
11 negative regulation of mitophagy GO:1901525 9.16 TSC2 TP53
12 uterus development GO:0060065 9.13 HOXA10 ESR1 CYP19A1
13 transcription initiation from RNA polymerase II promoter GO:0006367 9.02 PTEN PGR MED12 ESR2 ESR1

Molecular functions related to Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.83 TP53 PGR HOXA10 HMGA2 ESR1
2 enzyme binding GO:0019899 9.77 TP53 PTEN PGR ESR2 ESR1
3 steroid hormone receptor activity GO:0003707 9.58 PGR ESR2 ESR1
4 nuclear receptor activity GO:0004879 9.43 PGR ESR2 ESR1
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 TP53 PGR HOXA10 HMGA2 ESR2 ESR1
6 estrogen receptor activity GO:0030284 9.32 ESR2 ESR1
7 estrogen response element binding GO:0034056 9.16 ESR2 ESR1
8 steroid binding GO:0005496 8.8 PGR ESR2 ESR1

Sources for Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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