MCID: RPR002
MIFTS: 35

Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Reproductive System Disease

MalaCards integrated aliases for Reproductive System Disease:

Name: Reproductive System Disease 12 15 17
Abnormality of the Genital System 29 6
Reproductive System Disorder 70
Genital System Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:15
NCIt 50 C27613
UMLS 70 C0178829 C1335037

Summaries for Reproductive System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in reproductive system organs.

MalaCards based summary : Reproductive System Disease, also known as abnormality of the genital system, is related to male reproductive system disease and female reproductive system disease. An important gene associated with Reproductive System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Cell Differentiation - Index. The drugs insulin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include reproductive system, ovary and prostate.

Wikipedia : 73 A reproductive system disease is any disease of the reproductive... more...

Related Diseases for Reproductive System Disease

Diseases related to Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 male reproductive system disease 33.5 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
2 female reproductive system disease 33.5 SERPINA3 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A
3 uterine anomalies 32.6 SERPINA3 MIR9-1 MIR518D MIR34A MIR30A MIR221
4 endometriosis 32.5 MIR200A MIR199A1 MIR145 MIR143 MIR141 MIR126
5 endometriosis of ovary 32.5 MIR9-1 MIR221 MIR145 MIR141
6 aromatase excess syndrome 11.0
7 preterm premature rupture of the membranes 11.0
8 ectopic pregnancy 11.0
9 epididymis disease 11.0
10 pelvic inflammatory disease 11.0
11 fallopian tube endometriosis 11.0
12 endosalpingiosis 11.0
13 endometriosis of intestine 11.0
14 endometriosis of pelvic peritoneum 11.0
15 endometriosis in scar of skin 11.0
16 endometriosis of rectovaginal septum and vagina 11.0
17 vaginal disease 11.0
18 hernia of ovary and fallopian tube 11.0
19 prolapse of female genital organ 11.0
20 amenorrhea 11.0
21 masters-allen syndrome 11.0
22 fallopian tube disease 11.0
23 vulvar disease 11.0
24 vulvovaginitis 11.0
25 gynatresia 11.0
26 parovarian cyst 11.0
27 bartholin's gland disease 11.0
28 bartholin's duct cyst 11.0
29 gastrointestinal system disease 10.8 SERPINA3 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A
30 gastrointestinal system cancer 10.8 SERPINA3 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A
31 respiratory system disease 10.8 SERPINA3 MIR9-1 MIR518D MIR34A MIR30A MIR221
32 endocrine gland cancer 10.8 SERPINA3 MIR9-1 MIR518D MIR34A MIR30A MIR221
33 prostate disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
34 colonic disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
35 thoracic cancer 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
36 breast disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
37 immune system disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
38 lymphatic system disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
39 urinary system disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
40 stomach disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
41 male reproductive organ cancer 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
42 large intestine cancer 10.8 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
43 respiratory system cancer 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
44 intestinal disease 10.8 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
45 endocrine system disease 10.8 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
46 lymphatic system cancer 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
47 pancreas disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
48 arteries, anomalies of 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
49 nervous system disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
50 connective tissue disease 10.8 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21

Graphical network of the top 20 diseases related to Reproductive System Disease:



Diseases related to Reproductive System Disease

Symptoms & Phenotypes for Reproductive System Disease

Drugs & Therapeutics for Reproductive System Disease

Drugs for Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin
2 Hormones
3 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Metabolic Variations Upon the Activity of the Neuroendocrine Reproductive Axis in Normal Female Volunteers Completed NCT02233283
2 The Effect of Polycystic Ovary Syndrome on Pelvic Floor Structure and Function Completed NCT04398186
3 Costituzione Della Biobanca Del Microbiota Intestinale e Salivare Umano: Dalla Disbiosi Alla Simbiosi Not yet recruiting NCT04698109

Search NIH Clinical Center for Reproductive System Disease

Genetic Tests for Reproductive System Disease

Genetic tests related to Reproductive System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Genital System 29

Anatomical Context for Reproductive System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive System Disease:

19
Reproductive System

MalaCards organs/tissues related to Reproductive System Disease:

40
Ovary, Prostate, Pituitary

Publications for Reproductive System Disease

Articles related to Reproductive System Disease:

(show all 28)
# Title Authors PMID Year
1
Investigating the acute and sub-acute toxicity of medicinal Cuscuta chinensis Lam plant. 61
33705922 2021
2
Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. 61
33007577 2020
3
Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis. 61
32096023 2020
4
The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. 61
31929497 2020
5
Proteomic Profiling Change and Its Implies in the Early Mycosis Fungoides (MF) Using Isobaric Tags for Relative and Absolute Quantification (iTRAQ). 61
33299887 2020
6
Cardiac disorders and structural brain abnormalities are commonly associated with hypospadias in children with neurodevelopmental disorders. 61
30921090 2019
7
The role of microRNAs in chronic pseudomonas lung infection in Cystic fibrosis. 61
31047110 2019
8
An Analysis of Culling Patterns during the Breeding Cycle and Lifetime Production from the Aspect of Culling Reasons for Gilts and Sows in Southwest China. 61
31013730 2019
9
Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy. 61
30388265 2018
10
Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell lines in vitro. 61
30310654 2018
11
[Current status of reproductive health and its occupational influencing factors among female medical staff in a provincial maternal and child health hospital]. 61
30248735 2018
12
Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy. 61
27789200 2017
13
Characterization of the serum and liver proteomes in gut-microbiota-lacking mice. 61
28367086 2017
14
[Analysis on causes of death of residents in Beijing, 1965-1974]. 61
27453108 2016
15
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis. 61
26224097 2015
16
Survey of knowledge, attitude, and practice regarding reproductive health among urban men in China: a descriptive study. 61
25532571 2015
17
Pre- and post-partum mild underfeeding influences gene expression in the reproductive tract of cyclic dairy cows. 61
23131127 2013
18
Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos. 61
23063069 2013
19
Proteomic profiles of white sucker (Catostomus commersonii) sampled from within the Thunder Bay Area of Concern reveal up-regulation of proteins associated with tumor formation and exposure to environmental estrogens. 61
22260729 2012
20
[Analysis on reproductive health status and influencing factors of female workers of pharmaceutical industry in Gansu province]. 61
22356709 2011
21
[The occupational and procreation health of immigrant female workers in electron factory]. 61
22356711 2011
22
[The status of occupational health of female migrant workers in traditional Chinese medicine, western medicine and bio-pharmaceutical industry in Gansu province]. 61
22356710 2011
23
Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities. 61
21470681 2011
24
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models. 61
20976069 2010
25
Impact of methoxyacetic acid on mouse Leydig cell gene expression. 61
20565877 2010
26
Signaling pathway networks mined from human pituitary adenoma proteomics data. 61
20426862 2010
27
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation. 61
19562735 2009
28
Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. 61
19439102 2009

Variations for Reproductive System Disease

Expression for Reproductive System Disease

Search GEO for disease gene expression data for Reproductive System Disease.

Pathways for Reproductive System Disease

Pathways related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34A MIR30A MIR221 MIR21 MIR200A
2 10.71 MIR9-1 MIR221 MIR199A1
3 10.27 MIR199A1 MIR145

GO Terms for Reproductive System Disease

Cellular components related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 SERPINA3 MIR30A MIR221 MIR21 MIR199A1 MIR17
2 sperm plasma membrane GO:0097524 9.16 EPPIN CCR6
3 extracellular vesicle GO:1903561 9.1 MIR34A MIR30A MIR221 MIR21 MIR17 MIR126

Biological processes related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.81 MIR221 MIR145 MIR141 MIR126
2 negative regulation of angiogenesis GO:0016525 9.78 MIR34A MIR21 MIR145 MIR143
3 positive regulation of protein kinase B signaling GO:0051897 9.77 MIR221 MIR21 MIR199A1 MIR143 MIR126
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 MIR221 MIR21 MIR17
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.75 MIR221 MIR199A1 MIR196A1
6 positive regulation of angiogenesis GO:0045766 9.72 MIR30A MIR21 MIR199A1 MIR143 MIR126
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.7 MIR21 MIR199A1 MIR145
8 negative regulation of sprouting angiogenesis GO:1903671 9.67 MIR34A MIR221 MIR17
9 negative regulation of cell migration GO:0030336 9.65 MIR9-1 MIR34A MIR21 MIR145 MIR126
10 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.64 MIR34A MIR17
11 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.63 MIR199A1 MIR17
12 positive regulation of connective tissue replacement GO:1905205 9.63 MIR34A MIR199A1
13 negative regulation of vascular endothelial growth factor production GO:1904046 9.63 MIR34A MIR199A1 MIR17
14 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR199A1 MIR17
15 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.62 MIR221 MIR141
16 positive regulation of metalloendopeptidase activity GO:1904685 9.61 MIR21 MIR17
17 negative regulation of calcium ion import GO:0090281 9.61 MIR34A EPPIN
18 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.61 MIR221 MIR21 MIR143
19 angiotensin-activated signaling pathway GO:0038166 9.6 MIR145 MIR143
20 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.59 MIR21 MIR17
21 aorta smooth muscle tissue morphogenesis GO:0060414 9.57 MIR145 MIR143
22 negative regulation of interleukin-21 production GO:0032705 9.56 MIR221 MIR21
23 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.55 MIR17 MIR143
24 miRNA mediated inhibition of translation GO:0035278 9.55 MIR9-1 MIR221 MIR21 MIR17 MIR145
25 regulation of phenotypic switching GO:1900239 9.54 MIR145 MIR143
26 gene silencing by miRNA GO:0035195 9.5 MIR126 MIR141 MIR143 MIR145 MIR17 MIR196A1
27 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.4 MIR145 MIR143
28 positive regulation of blood vessel endothelial cell migration GO:0043536 9.35 MIR30A MIR221 MIR200A MIR143 MIR126

Molecular functions related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.61 MIR9-1 MIR34A MIR30A MIR21 MIR17 MIR145
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR9-1 MIR518A1 MIR34A MIR30A MIR221 MIR21

Sources for Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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