MCID: RPR002
MIFTS: 43

Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Reproductive System Disease

MalaCards integrated aliases for Reproductive System Disease:

Name: Reproductive System Disease 12 15
Abnormality of the Genital System 29 6
Reproductive System Disorder 73
Genital System Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:15
NCIt 50 C27613

Summaries for Reproductive System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in reproductive system organs.

MalaCards based summary : Reproductive System Disease, also known as abnormality of the genital system, is related to male reproductive system disease and female reproductive system disease. An important gene associated with Reproductive System Disease is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Insulin, Globin Zinc and Hormones have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and colon, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell death HMECs cells

Wikipedia : 76 A reproductive system disease is any disease of the reproductive... more...

Related Diseases for Reproductive System Disease

Diseases related to Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 male reproductive system disease 34.0 AKT1 AR AREG FOLH1 GNRH1 KLK3
2 female reproductive system disease 33.9 AKT1 AMH AREG BRCA1 BRCA2 ESR1
3 fallopian tube disease 32.0 BRCA1 BRCA2 MAPK8IP1
4 endometriosis of ovary 31.9 AMH ESR1 PGR
5 bartholin's duct cyst 31.9 AR TP53
6 endometriosis 31.9 ESR1 GNRH1 PGR PTEN
7 uterine anomalies 31.8 AKT1 AREG ESR1 MAPK8IP1 MAPK8IP2 PGR
8 aromatase excess syndrome 10.9
9 preterm premature rupture of the membranes 10.9
10 ectopic pregnancy 10.9
11 pelvic inflammatory disease 10.9
12 fallopian tube endometriosis 10.9
13 endosalpingiosis 10.9
14 endometriosis of intestine 10.9
15 endometriosis of pelvic peritoneum 10.9
16 endometriosis in scar of skin 10.9
17 endometriosis of rectovaginal septum and vagina 10.9
18 vaginal disease 10.9
19 hernia of ovary and fallopian tube 10.9
20 prolapse of female genital organ 10.9
21 amenorrhea 10.9
22 masters-allen syndrome 10.9
23 vulvovaginitis 10.9
24 gynatresia 10.9
25 parovarian cyst 10.9
26 hereditary site-specific ovarian cancer syndrome 10.4 BRCA1 BRCA2
27 carcinosarcoma 10.4 PGR PTEN TP53
28 nosophobia 10.4 BRCA1 BRCA2 PGR
29 cancerophobia 10.4 BRCA1 BRCA2 PGR
30 submandibular gland cancer 10.4 KLK3 TP53
31 fallopian tube adenocarcinoma 10.4 BRCA1 BRCA2 MAPK8IP1
32 nodular prostate 10.4 AR FOLH1 GNRH1 KLK3
33 prostate small cell carcinoma 10.4 FOLH1 KLK3 PTEN
34 small cell carcinoma 10.4 KLK3 PTEN TP53
35 prostatic hyperplasia, benign 10.4 AR FOLH1 KLK3
36 uterine corpus serous adenocarcinoma 10.4 BRCA1 TP53 TUBB3
37 breast medullary carcinoma 10.4 BRCA1 ESR1 PGR
38 premature menopause 10.4 AMH BRCA1 BRCA2 GNRH1
39 bartholin's gland disease 10.4 AR PGR TP53
40 papillary serous adenocarcinoma 10.4 BRCA1 PGR TP53
41 endometrium carcinoma in situ 10.4 PGR TP53
42 oncocytic breast carcinoma 10.4 AR ESR1 PGR
43 endometrial squamous cell carcinoma 10.4 AR ESR1 PGR
44 corneal abscess 10.4 AR PGR PTEN
45 breast duct papilloma 10.4 PGR PTEN
46 breast adenoid cystic carcinoma 10.4 AR ESR1 PGR
47 apocrine adenocarcinoma 10.4 AR ESR1 PGR
48 peritoneal benign neoplasm 10.4 AR ESR1 PGR
49 gender identity disorder 10.4 AR ESR1 PGR
50 sex differentiation disease 10.4 AMH AR GNRH1

Graphical network of the top 20 diseases related to Reproductive System Disease:



Diseases related to Reproductive System Disease

Symptoms & Phenotypes for Reproductive System Disease

GenomeRNAi Phenotypes related to Reproductive System Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.73 AMH BRCA1 BRCA2 ESR1 KLK3 MAPK8IP1
2 Increased cell death HMECs cells GR00103-A-0 9.1 AREG BRCA1 KLK3 PGR PTEN TP53

MGI Mouse Phenotypes related to Reproductive System Disease:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 AKT1 AMH AR AREG BRCA1 BRCA2
2 endocrine/exocrine gland MP:0005379 10.4 AKT1 AMH AR AREG BRCA1 BRCA2
3 cellular MP:0005384 10.36 AKT1 AR BRCA1 BRCA2 ESR1 MAPK8IP1
4 growth/size/body region MP:0005378 10.36 AKT1 AR AREG BRCA1 BRCA2 ESR1
5 behavior/neurological MP:0005386 10.33 AKT1 AR BRCA1 BRCA2 ESR1 MAPK8IP1
6 immune system MP:0005387 10.32 AKT1 AR AREG BRCA1 BRCA2 ESR1
7 hematopoietic system MP:0005397 10.28 AKT1 AR AREG BRCA1 BRCA2 ESR1
8 mortality/aging MP:0010768 10.28 AKT1 AR AREG BRCA1 BRCA2 ESR1
9 integument MP:0010771 10.24 AKT1 AR AREG BRCA1 BRCA2 ESR1
10 digestive/alimentary MP:0005381 10.23 AR AREG BRCA1 BRCA2 ESR1 GNRH1
11 embryo MP:0005380 10.22 AKT1 AR BRCA1 BRCA2 ESR1 PGR
12 neoplasm MP:0002006 10.18 AKT1 AMH AR BRCA1 BRCA2 ESR1
13 nervous system MP:0003631 10.15 AKT1 AR BRCA1 BRCA2 ESR1 GNRH1
14 adipose tissue MP:0005375 10.14 AKT1 AR BRCA1 ESR1 PTEN TP53
15 liver/biliary system MP:0005370 10.06 AKT1 AR ESR1 GNRH1 MAPK8IP1 PTEN
16 limbs/digits/tail MP:0005371 10.02 AR BRCA1 BRCA2 ESR1 PGR PTEN
17 normal MP:0002873 10.02 AKT1 AR BRCA1 BRCA2 ESR1 GNRH1
18 reproductive system MP:0005389 10 AKT1 AMH AR AREG BRCA1 BRCA2
19 renal/urinary system MP:0005367 9.86 AR BRCA1 ESR1 GNRH1 PTEN TLR9
20 respiratory system MP:0005388 9.5 AKT1 BRCA1 ESR1 PTEN TMPRSS2 TP53
21 skeleton MP:0005390 9.28 AKT1 AR BRCA1 BRCA2 ESR1 GNRH1

Drugs & Therapeutics for Reproductive System Disease

Drugs for Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insulin, Globin Zinc Not Applicable
2 Hormones Not Applicable
3 insulin Not Applicable
4 Acidophilus Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283 Not Applicable
2 Evaluate the Use of a New Probiotic Strain in Couples With Fertility Problems and Dysbiosis. Recruiting NCT03701893 Not Applicable
3 Inherited Reproductive Disorders Recruiting NCT01500447

Search NIH Clinical Center for Reproductive System Disease

Genetic Tests for Reproductive System Disease

Genetic tests related to Reproductive System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Genital System 29

Anatomical Context for Reproductive System Disease

MalaCards organs/tissues related to Reproductive System Disease:

41
Lung, Bone, Colon, Tongue, Ovary, Prostate, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive System Disease:

19
Reproductive System Organs

Publications for Reproductive System Disease

Variations for Reproductive System Disease

Expression for Reproductive System Disease

Search GEO for disease gene expression data for Reproductive System Disease.

Pathways for Reproductive System Disease

Pathways related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 AKT1 AREG BRCA1 ESR1 GNRH1 MAPK8IP1
2
Show member pathways
13.48 AKT1 AREG BRCA1 GNRH1 MAPK8IP1 MAPK8IP2
3
Show member pathways
13.31 AKT1 AR AREG GNRH1 MAPK8IP1 MAPK8IP2
4
Show member pathways
12.99 AKT1 AREG GNRH1 PSMA1 PTEN TP53
5
Show member pathways
12.74 AR BRCA1 ESR1 PSMA1 PTEN TP53
6 12.7 AKT1 AR BRCA2 ESR1 KLK3 PTEN
7 12.69 AKT1 AREG MAPK8IP1 MAPK8IP2 TP53
8
Show member pathways
12.67 AKT1 BRCA1 BRCA2 ESR1 PTEN TP53
9
Show member pathways
12.62 BRCA1 BRCA2 ESR1 PSMA1 TP53
10
Show member pathways
12.53 AKT1 BRCA1 BRCA2 ESR1 PGR PTEN
11
Show member pathways
12.5 AKT1 AR AREG BRCA2 KLK3 PTEN
12
Show member pathways
12.13 AKT1 BRCA1 PSMA1 PTEN TP53
13
Show member pathways
12.03 AKT1 AR KLK3 PTEN
14 11.82 AKT1 AR ESR1
15 11.8 AKT1 PTEN TP53
16
Show member pathways
11.79 AR ESR1 PGR
17 11.76 AKT1 PTEN TP53
18
Show member pathways
11.74 BRCA1 BRCA2 TP53
19 11.7 AKT1 AR ESR1
20 11.67 AKT1 BRCA1 TP53
21 11.61 AKT1 AR BRCA1 KLK3 PTEN
22 11.6 AKT1 BRCA1 PTEN TP53
23 11.59 AKT1 PTEN TP53
24 11.5 AKT1 BRCA1 BRCA2 TP53
25 11.5 AKT1 PTEN TP53
26 11.47 AKT1 BRCA1 TP53
27 11.45 AR KLK3 TMPRSS2
28
Show member pathways
11.37 AR BRCA1 ESR1 KLK3
29 11.35 AKT1 AR BRCA1 BRCA2 ESR1 PTEN
30 11.33 AKT1 BRCA1 PTEN TP53
31 11.3 ESR1 PTEN TP53
32 11.2 AKT1 BRCA1 TP53
33 11.11 AKT1 AR BRCA1 KLK3 TMPRSS2
34 10.93 AKT1 AR GNRH1

GO Terms for Reproductive System Disease

Cellular components related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.83 AKT1 AR AREG BRCA1 BRCA2 ESR1
2 protein-containing complex GO:0032991 9.23 AKT1 AR BRCA1 BRCA2 ESR1 KLK3

Biological processes related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.91 AKT1 BRCA1 ESR1 TP53
2 aging GO:0007568 9.86 AKT1 AMH GNRH1 PTEN
3 cell proliferation GO:0008283 9.8 AKT1 AR AREG BRCA2 PTEN TP53
4 excitatory postsynaptic potential GO:0060079 9.77 AKT1 MAPK8IP2 TRPV1
5 cell-cell signaling GO:0007267 9.77 AMH AR AREG GNRH1 PGR
6 response to organic cyclic compound GO:0014070 9.76 AMH AREG GNRH1 PTEN
7 response to peptide hormone GO:0043434 9.74 AREG GNRH1 TRPV1
8 steroid hormone mediated signaling pathway GO:0043401 9.72 AR ESR1 PGR
9 response to estradiol GO:0032355 9.71 AREG BRCA2 ESR1 PTEN
10 cellular response to nerve growth factor stimulus GO:1990090 9.65 AKT1 PTEN TRPV1
11 regulation of systemic arterial blood pressure GO:0003073 9.62 AR KLK3
12 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.61 ESR1 TP53
13 negative regulation of cell size GO:0045792 9.6 AKT1 PTEN
14 prostate gland growth GO:0060736 9.58 AR PTEN
15 cellular response to decreased oxygen levels GO:0036294 9.52 AKT1 PTEN
16 chordate embryonic development GO:0043009 9.51 BRCA1 BRCA2
17 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.49 AREG ESR1
18 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.43 AR PGR
19 mammary gland alveolus development GO:0060749 9.43 AR AREG ESR1
20 protein deubiquitination GO:0016579 9.43 AR BRCA1 ESR1 PSMA1 PTEN TP53
21 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 BRCA1 BRCA2 TP53
22 positive regulation of gene expression GO:0010628 9.17 AKT1 AMH AR BRCA1 PTEN TLR9
23 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 AKT1 AR BRCA1 ESR1 PGR TLR9
24 positive regulation of transcription, DNA-templated GO:0045893 10.01 AKT1 AR BRCA1 BRCA2 ESR1 TP53

Molecular functions related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.63 AR ESR1 PGR
2 protein kinase binding GO:0019901 9.63 AKT1 ESR1 MAPK8IP1 MAPK8IP2 PTEN TP53
3 identical protein binding GO:0042802 9.56 AKT1 BRCA1 BRCA2 ESR1 PGR PTEN
4 steroid hormone receptor activity GO:0003707 9.54 AR ESR1 PGR
5 nuclear receptor activity GO:0004879 9.5 AR ESR1 PGR
6 nitric-oxide synthase regulator activity GO:0030235 9.43 AKT1 ESR1
7 steroid binding GO:0005496 9.43 AR ESR1 PGR
8 MAP-kinase scaffold activity GO:0005078 9.4 MAPK8IP1 MAPK8IP2
9 enzyme binding GO:0019899 9.17 AKT1 AR BRCA1 ESR1 PGR PTEN

Sources for Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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