MCID: RPR002
MIFTS: 36

Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Reproductive System Disease

MalaCards integrated aliases for Reproductive System Disease:

Name: Reproductive System Disease 12 15 17
Abnormality of the Genital System 29 6
Reproductive System Disorder 71
Genital System Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:15
NCIt 49 C27613
UMLS 71 C0178829 C1335037

Summaries for Reproductive System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in reproductive system organs.

MalaCards based summary : Reproductive System Disease, also known as abnormality of the genital system, is related to male reproductive system disease and female reproductive system disease. An important gene associated with Reproductive System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Cell Differentiation - Index. The drugs Hormones and insulin have been mentioned in the context of this disorder. Affiliated tissues include reproductive system, breast and bone.

Wikipedia : 74 A reproductive system disease is any disease of the reproductive... more...

Related Diseases for Reproductive System Disease

Diseases related to Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 male reproductive system disease 35.5 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
2 female reproductive system disease 35.5 SERPINA3 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A
3 uterine anomalies 33.1 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
4 endometriosis 33.0 MIR200A MIR199A1 MIR145 MIR143 MIR141 MIR126
5 endometriosis of ovary 32.9 MIR9-1 MIR145 MIR141
6 connective tissue disease 31.1 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
7 vascular disease 31.0 MIR221 MIR21 MIR199A1 MIR145 MIR143 MIR126
8 aromatase excess syndrome 11.1
9 preterm premature rupture of the membranes 11.1
10 ectopic pregnancy 11.1
11 pelvic inflammatory disease 11.1
12 fallopian tube endometriosis 11.1
13 endosalpingiosis 11.1
14 endometriosis of intestine 11.1
15 endometriosis of pelvic peritoneum 11.1
16 endometriosis in scar of skin 11.1
17 endometriosis of rectovaginal septum and vagina 11.1
18 vaginal disease 11.1
19 hernia of ovary and fallopian tube 11.1
20 prolapse of female genital organ 11.1
21 amenorrhea 11.1
22 masters-allen syndrome 11.1
23 fallopian tube disease 11.1
24 vulvovaginitis 11.1
25 gynatresia 11.1
26 parovarian cyst 11.1
27 bartholin's gland disease 11.1
28 bartholin's duct cyst 11.1
29 lung cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
30 gonadal disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
31 male reproductive organ cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
32 respiratory system disease 11.0 SERPINA3 MIR9-1 MIR518D MIR34A MIR30A MIR221
33 prostate disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
34 thoracic cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
35 gastrointestinal system cancer 11.0 SERPINA3 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A
36 pancreas disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
37 nervous system disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
38 urinary system disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
39 respiratory system cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
40 endocrine system disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
41 endocrine gland cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
42 arteries, anomalies of 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
43 gastrointestinal system disease 11.0 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
44 intestinal disease 11.0 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
45 breast disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
46 cell type cancer 11.0 SERPINA3 MIR9-1 MIR518A1 MIR34A MIR30A MIR221
47 hematologic cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21
48 colonic disease 11.0 MIR9-1 MIR34A MIR30A MIR221 MIR21 MIR200A
49 nervous system cancer 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR21 MIR200A
50 stomach disease 11.0 SERPINA3 MIR9-1 MIR34A MIR30A MIR221 MIR21

Graphical network of the top 20 diseases related to Reproductive System Disease:



Diseases related to Reproductive System Disease

Symptoms & Phenotypes for Reproductive System Disease

Drugs & Therapeutics for Reproductive System Disease

Drugs for Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 insulin
3 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Metabolic Variations Upon the Activity of the Neuroendocrine Reproductive Axis in Normal Female Volunteers Completed NCT02233283

Search NIH Clinical Center for Reproductive System Disease

Genetic Tests for Reproductive System Disease

Genetic tests related to Reproductive System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Genital System 29

Anatomical Context for Reproductive System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive System Disease:

19
Reproductive System

MalaCards organs/tissues related to Reproductive System Disease:

40
Breast, Bone, Thyroid, Skin, Ovary, Lung, Prostate

Publications for Reproductive System Disease

Articles related to Reproductive System Disease:

(show all 24)
# Title Authors PMID Year
1
The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. 61
31929497 2020
2
Cardiac disorders and structural brain abnormalities are commonly associated with hypospadias in children with neurodevelopmental disorders. 61
30921090 2019
3
The role of microRNAs in chronic pseudomonas lung infection in Cystic fibrosis. 61
31047110 2019
4
An Analysis of Culling Patterns during the Breeding Cycle and Lifetime Production from the Aspect of Culling Reasons for Gilts and Sows in Southwest China. 61
31013730 2019
5
Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy. 61
30388265 2018
6
Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell lines in vitro. 61
30310654 2018
7
[Current status of reproductive health and its occupational influencing factors among female medical staff in a provincial maternal and child health hospital]. 61
30248735 2018
8
Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy. 61
27789200 2017
9
Characterization of the serum and liver proteomes in gut-microbiota-lacking mice. 61
28367086 2017
10
[Analysis on causes of death of residents in Beijing, 1965-1974]. 61
27453108 2016
11
Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis. 61
26224097 2015
12
Survey of knowledge, attitude, and practice regarding reproductive health among urban men in China: a descriptive study. 61
25532571 2015
13
Pre- and post-partum mild underfeeding influences gene expression in the reproductive tract of cyclic dairy cows. 61
23131127 2013
14
Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos. 61
23063069 2013
15
Proteomic profiles of white sucker (Catostomus commersonii) sampled from within the Thunder Bay Area of Concern reveal up-regulation of proteins associated with tumor formation and exposure to environmental estrogens. 61
22260729 2012
16
[The occupational and procreation health of immigrant female workers in electron factory]. 61
22356711 2011
17
[Analysis on reproductive health status and influencing factors of female workers of pharmaceutical industry in Gansu province]. 61
22356709 2011
18
[The status of occupational health of female migrant workers in traditional Chinese medicine, western medicine and bio-pharmaceutical industry in Gansu province]. 61
22356710 2011
19
Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities. 61
21470681 2011
20
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models. 61
20976069 2010
21
Impact of methoxyacetic acid on mouse Leydig cell gene expression. 61
20565877 2010
22
Signaling pathway networks mined from human pituitary adenoma proteomics data. 61
20426862 2010
23
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation. 61
19562735 2009
24
Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. 61
19439102 2009

Variations for Reproductive System Disease

ClinVar genetic disease variations for Reproductive System Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;X;t(Y;3)(p11.2;p12.3)dnTranslocation Likely pathogenic 267818

Expression for Reproductive System Disease

Search GEO for disease gene expression data for Reproductive System Disease.

Pathways for Reproductive System Disease

Pathways related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34A MIR30A MIR221 MIR21 MIR200A
2 10.71 MIR9-1 MIR221 MIR199A1
3 10.27 MIR199A1 MIR145

GO Terms for Reproductive System Disease

Cellular components related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 SERPINA3 MIR30A MIR221 MIR21 MIR199A1 MIR17
2 sperm plasma membrane GO:0097524 8.96 EPPIN CCR6

Biological processes related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.73 MIR34A MIR21 MIR145 MIR143
2 positive regulation of protein kinase B signaling GO:0051897 9.72 MIR221 MIR21 MIR199A1 MIR143 MIR126
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.71 MIR221 MIR21 MIR17
4 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.67 MIR21 MIR199A1 MIR145
5 negative regulation of sprouting angiogenesis GO:1903671 9.65 MIR34A MIR221 MIR17
6 positive regulation of angiogenesis GO:0045766 9.65 MIR30A MIR21 MIR199A1 MIR143 MIR126
7 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.61 MIR199A1 MIR17
8 positive regulation of connective tissue replacement GO:1905205 9.6 MIR34A MIR199A1
9 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.59 MIR199A1 MIR17
10 positive regulation of metalloendopeptidase activity GO:1904685 9.58 MIR21 MIR17
11 negative regulation of calcium ion import GO:0090281 9.58 MIR34A EPPIN
12 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.58 MIR221 MIR21 MIR143
13 angiotensin-activated signaling pathway GO:0038166 9.57 MIR145 MIR143
14 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.56 MIR21 MIR17
15 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.55 MIR221 MIR141
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.55 MIR30A MIR221 MIR200A MIR143 MIR126
17 aorta smooth muscle tissue morphogenesis GO:0060414 9.52 MIR145 MIR143
18 regulation of phenotypic switching GO:1900239 9.51 MIR145 MIR143
19 gene silencing by miRNA GO:0035195 9.5 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A MIR221
20 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.46 MIR17 MIR143
21 miRNA mediated inhibition of translation GO:0035278 9.43 MIR9-1 MIR30A MIR221 MIR21 MIR17 MIR145
22 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.37 MIR145 MIR143

Molecular functions related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.5 MIR9-1 MIR518D MIR518A1 MIR34A MIR30A MIR221

Sources for Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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