MCID: RSS022
MIFTS: 11

Resistance to Tamoxifene

Categories: Rare diseases

Aliases & Classifications for Resistance to Tamoxifene

MalaCards integrated aliases for Resistance to Tamoxifene:

Name: Resistance to Tamoxifene 59

Classifications:



External Ids:

Orphanet 59 ORPHA240947

Summaries for Resistance to Tamoxifene

MalaCards based summary : Resistance to Tamoxifene is related to breast cancer and estrogen-receptor positive breast cancer. Affiliated tissues include b cells.

Related Diseases for Resistance to Tamoxifene

Diseases related to Resistance to Tamoxifene via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast cancer 10.1
2 estrogen-receptor positive breast cancer 9.9
3 ovarian cancer 9.6
4 b-cell lymphomas 9.6
5 lymphoma 9.6

Graphical network of the top 20 diseases related to Resistance to Tamoxifene:



Diseases related to Resistance to Tamoxifene

Symptoms & Phenotypes for Resistance to Tamoxifene

Drugs & Therapeutics for Resistance to Tamoxifene

Search Clinical Trials , NIH Clinical Center for Resistance to Tamoxifene

Genetic Tests for Resistance to Tamoxifene

Anatomical Context for Resistance to Tamoxifene

MalaCards organs/tissues related to Resistance to Tamoxifene:

41
B Cells

Publications for Resistance to Tamoxifene

Articles related to Resistance to Tamoxifene:

(show all 26)
# Title Authors Year
1
Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors. ( 29719270 )
2018
2
Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer. ( 29626519 )
2018
3
Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer. ( 28635401 )
2017
4
Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. ( 28637868 )
2017
5
Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer. ( 26657294 )
2016
6
Involvement of multiple cellular pathways in regulating resistance to tamoxifen in BIK-suppressed MCF-7 cells. ( 25861752 )
2015
7
Mechanisms associated with resistance to tamoxifen in estrogen receptor-positive breast cancer (review). ( 24841429 )
2014
8
Autocrine production of interleukin-6 confers ovarian cancer cells resistance to tamoxifen via ER isoforms and SRC-1. ( 24189439 )
2014
9
USP9X downregulation renders breast cancer cells resistant to tamoxifen. ( 25028367 )
2014
10
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling. ( 23991038 )
2013
11
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway. ( 21690342 )
2012
12
The impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen treatment in breast cancer patients. ( 22892847 )
2012
13
Loss of Rho GDII+ and resistance to tamoxifen via effects on estrogen receptor I+. ( 21447808 )
2011
14
Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. ( 20234815 )
2010
15
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305. ( 19205871 )
2010
16
Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines. ( 20689759 )
2010
17
New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. ( 19061482 )
2009
18
PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. ( 17627277 )
2007
19
[Relation between c-erbB1, c-erbB2, MAPK expression and resistance to tamoxifen in breast cancer cells in vitro]. ( 17416003 )
2006
20
Changes in oestrogen receptor-alpha and -beta during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells. ( 16533599 )
2006
21
Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. ( 15569979 )
2004
22
Possible interaction between activator protein-1 and proto-oncogene B-cell lymphoma gene 6 in breast cancer patients resistant to tamoxifen. ( 15488654 )
2004
23
A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen. ( 14722733 )
2004
24
Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer. ( 11774281 )
2002
25
Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer. ( 12223126 )
2002
26
A metastatic breast tumor cell line, GI-101A, is estrogen receptor positive and responsive to estrogen but resistant to tamoxifen. ( 10328849 )
1998

Variations for Resistance to Tamoxifene

Expression for Resistance to Tamoxifene

Search GEO for disease gene expression data for Resistance to Tamoxifene.

Pathways for Resistance to Tamoxifene

GO Terms for Resistance to Tamoxifene

Sources for Resistance to Tamoxifene

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74 UMLS via Orphanet
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