RTHA
MCID: RSS029
MIFTS: 16

Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha (RTHA)

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

MalaCards integrated aliases for Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha:

Name: Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha 58
Resistance to Thyroid Hormone Due to a Mutation in Tra 58
Resistance to Thyroid Hormone Alpha 58
Rtha 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Orphanet 58 ORPHA566231

Summaries for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

MalaCards based summary : Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha, also known as resistance to thyroid hormone due to a mutation in tra, is related to apraxia and hypothyroidism. An important gene associated with Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha is THRA (Thyroid Hormone Receptor Alpha). The drugs Tranexamic Acid and Iron have been mentioned in the context of this disorder. Affiliated tissues include thyroid and bone.

Related Diseases for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Diseases in the Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha family:

Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Beta

Diseases related to Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 apraxia 9.9
2 hypothyroidism 9.9
3 constipation 9.9
4 hypotonia 9.9

Symptoms & Phenotypes for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Drugs & Therapeutics for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Drugs for Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
3 Hemostatics Phase 4
4 Antifibrinolytic Agents Phase 4
5 Coagulants Phase 4
6
Cimetidine Approved, Investigational Phase 2 51481-61-9 2756

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty: a Randomized Controlled Trial Completed NCT02747615 Phase 4 intravenous tranexamic acid (TXA) infusion
2 The Effect of Implant Design on Postoperative Mechanical Muscle Function Recovery and Gait in Hip Replacement Patients: A Randomized Clinical Trail Completed NCT01229293 Phase 2

Search NIH Clinical Center for Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha

Genetic Tests for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Anatomical Context for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

MalaCards organs/tissues related to Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha:

40
Thyroid, Bone

Publications for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Articles related to Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha:

(show all 47)
# Title Authors PMID Year
1
Low Revision Rates at More Than 10 Years for Dual-Mobility Cups Cemented Into Cages in Complex Revision Total Hip Arthroplasty. 61
31543421 2020
2
Dual Mobility Cups in Revision Total Hip Arthroplasty: Efficient Strategy to Decrease Dislocation Risk. 61
31563399 2020
3
Mid-term results after revision total hip arthroplasty with custom-made acetabular implants in patients with Paprosky III acetabular bone loss. 61
31820093 2020
4
Short-term outcomes with the REDAPT monolithic, tapered, fluted, grit-blasted, forged titanium revision femoral stem. 61
32009430 2020
5
Acetabular custom-made implants for severe acetabular bone defect in revision total hip arthroplasty: a systematic review of the literature. 61
31960168 2020
6
Unaddressed arterial injuries in revision total hip arthroplasty: mortality outcomes of a low-prevalence complication. 61
31222421 2020
7
Severe Obesity Increases Risk of Infection After Revision Total Hip Arthroplasty. 61
31447256 2019
8
Venous Thromboembolism Rates Did Not Decrease in Lower Extremity Revision Total Joint Arthroplasty From 2008 to 2016. 61
31153709 2019
9
Preoperative Depression Is Associated With Increased Risk Following Revision Total Joint Arthroplasty. 61
31848077 2019
10
Surgical repair for abductor lesion after revision total hip arthroplasty: a systematic review. 61
31777283 2019
11
Radiographic and Clinical Outcomes of Modular Tapered Fluted Stems for Femoral Revision for Paprosky III and IV Femoral Defects or Vancouver B2 and B3 Femoral Fractures. 61
31870582 2019
12
Comparing Inpatient Complication Rates between Octogenarians and Nonagenarians Following Primary and Revision Total Hip Arthroplasty in a Nationally Representative Sample 2010-2014. 61
31581504 2019
13
Dual-mobility cups in revision acetabular reconstructions: Short-term outcomes in high-risk patients for instability. 61
31281078 2019
14
The Effect of Body Mass Index on 30-day Complications After Revision Total Hip and Knee Arthroplasty. 61
30846315 2019
15
Frailty Predicts Medical Complications, Length of Stay, Readmission, and Mortality in Revision Hip and Knee Arthroplasty. 61
30930155 2019
16
Nonmodular Stems Are a Viable Alternative to Modular Stems in Revision Total Hip Arthroplasty. 61
31010773 2019
17
Clinical outcomes and dislocation rates after hip reconstruction using the Bioball system. 61
31257925 2019
18
Return to activity following revision total hip arthroplasty. 61
30535720 2019
19
How to prevent dislocation after revision total hip arthroplasty: a systematic review of the risk factors and a focus on treatment options. 61
30203338 2018
20
The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway. 61
29940143 2018
21
Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts. 61
30082761 2018
22
Multiple total hip arthroplasties in refractory immune thrombocytopenic purpura: A case report and literature review. 61
29642159 2018
23
Inadvertent hypothermia in hip and knee total joint arthroplasty. 61
29379254 2018
24
Reducing Blood Loss in Revision Total Hip and Knee Arthroplasty: Tranexamic Acid Is Effective in Aseptic Revisions and in Second-Stage Reimplantations for Periprosthetic Infection. 61
30584533 2018
25
Identification of a new gene yecC involved in threonine export in Escherichia coli. 61
28911185 2017
26
Variations in native protein glycation and plasma antioxidants in several birds of prey. 61
28529085 2017
27
Robotic-Assisted Total Hip Arthroplasty: Outcomes at Minimum Two-Year Follow-Up. 61
28537647 2017
28
Robotic-arm assisted total hip arthroplasty results in smaller acetabular cup size in relation to the femoral head size: a matched-pair controlled study. 61
28362049 2017
29
Subperitoneal approach in revision arthroplasty for acetabular component protrusion: Analysis of practices within the French Hip and Knee Society (SFHG). 61
27876582 2017
30
Improved Functional Outcomes with Robotic Compared with Manual Total Hip Arthroplasty. 61
27728953 2016
31
Validation of the Charlson comorbidity index in patients undergoing revision total hip arthroplasty. 61
26105762 2015
32
Quantifying the Burden of Revision Total Joint Arthroplasty for Periprosthetic Infection. 61
25865815 2015
33
The Incidence of and Risk Factors for 30-Day Surgical Site Infections Following Primary and Revision Total Joint Arthroplasty. 61
26071247 2015
34
The Müller acetabular reinforcement ring--still an option in acetabular revision of Paprosky 2 defects? Longterm results after 10 years. 61
26280965 2015
35
Leg-Length Discrepancy After Total Hip Arthroplasty: Comparison of Robot-Assisted Posterior, Fluoroscopy-Guided Anterior, and Conventional Posterior Approaches. 61
26046996 2015
36
[Experience of application of a radiofrequency thermoablation in the treatment of metastatic colorectal cancer]. 61
24502005 2013
37
Dimensions of disinhibited personality and their relation with alcohol use and problems. 61
23588138 2013
38
Redefining revision total hip arthroplasty based on hospital admission status. 61
22019324 2012
39
Trends in incidence and outcomes of revision total hip arthroplasty in Spain: a population based study. 61
22429798 2012
40
A well-fixed femoral stem facing a failed acetabular component: to exchange or not? A 5- to 15-year follow-up study. 61
22245150 2012
41
Hospital cost of treating early dislocation following hip arthroplasty. 61
22362504 2012
42
Transfusion practice in hip arthroplasty--a nationwide study. 61
21029109 2011
43
Bone mineral density of the femoral neck in resurfacing hip arthroplasty. 61
20367420 2010
44
[Role of sagittal spinal curvature in early dislocation after revision total hip arthroplasty: prospective analysis of 49 revision procedures]. 61
15211271 2004
45
Virulence of raptor-origin Pasteurella multocida in domestic chickens. 61
10396641 1999
46
The effect of route of inoculation on the virulence of raptorial Pasteurella multocida isolates in Pekin ducks (Anas platyrhynchos). 61
10216767 1999
47
Aprotinin decreases blood loss in patients undergoing revision or bilateral total hip arthroplasty. 61
7529467 1995

Variations for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Expression for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Search GEO for disease gene expression data for Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Alpha.

Pathways for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

GO Terms for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

Sources for Resistance to Thyroid Hormone Due to a Mutation in Thyroid...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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