MCID: RSP021
MIFTS: 41

Respiratory Allergy

Categories: Immune diseases, Respiratory diseases

Aliases & Classifications for Respiratory Allergy

MalaCards integrated aliases for Respiratory Allergy:

Name: Respiratory Allergy 12 15
Airway Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060496

Summaries for Respiratory Allergy

Disease Ontology : 12 An allergic disease that is located in the respiratory tract.

MalaCards based summary : Respiratory Allergy, also known as airway allergy, is related to allergic rhinitis and rhinitis. An important gene associated with Respiratory Allergy is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ephedrine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, skin and t cells, and related phenotype is liver/biliary system.

Related Diseases for Respiratory Allergy

Diseases related to Respiratory Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 allergic rhinitis 31.0 RNASE3 IL5 IL4R IL4 IL13 IL10
2 rhinitis 31.0 RNASE3 IL5 IL4R IL4 IL13 IL10
3 pollen allergy 30.7 SCP2 RNASE3 PDCL PDC IL5 IL4R
4 ige responsiveness, atopic 30.7 RNASE3 IL5 IL4R IL4 IL13 IL10
5 cytokine deficiency 30.6 IL5 IL13
6 bronchitis 30.5 RNASE3 IL5 IL4 IL13 IL10
7 conjunctivitis 30.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
8 allergic asthma 30.4 RNASE3 IL5 IL4R IL4 IL3 IL13
9 hypereosinophilic syndrome 30.3 RNASE3 IL5 IL4 IL3 IL13 IGHE
10 extrinsic allergic alveolitis 30.2 IL10 IGHE CCR6
11 vasomotor rhinitis 30.2 RNASE3 IL5 IL13
12 chronic urticaria 30.2 RNASE3 IL4 IL3 IL13 IGHE
13 allergic conjunctivitis 30.2 RNASE3 IL5 IL4 IL13 IL10 IGHE
14 cough variant asthma 30.1 RNASE3 IL5 IL4 IGHE
15 cow milk allergy 30.1 IL5 IL4 IL10
16 contact dermatitis 30.1 IL5 IL4 IL10 CCR6
17 otitis media 30.1 RNASE3 IL5 IL4 IL10 IGHE
18 urticaria 30.1 RNASE3 IL5 IL4 IL3 IL13 IL10
19 allergic disease 30.0 RNASE3 IL5 IL4R IL4 IL3 IL13
20 pneumonia 30.0 IL5 IL4 IL13 IL10
21 tetanus 29.9 IL5 IL4 IL13 IL10
22 proteasome-associated autoinflammatory syndrome 1 29.9 RNASE3 IL5 IL4 IL13 IL10 IGHE
23 food allergy 29.9 SCP2 RNASE3 IL5 IL4R IL4 IL13
24 diphtheria 29.9 IL5 IL4 IL3 IL2RB IL13
25 esophagitis 29.9 RNASE3 IL5 IL4 IL13 IL10
26 allergic contact dermatitis 29.9 IL5 IL4 IL10 CCR6
27 anisakiasis 29.9 RNASE3 IGHE
28 dermatitis 29.8 RNASE3 IL5 IL4R IL4 IL2RB IL13
29 ulcerative colitis 29.8 IL4 IL13 IL10 CCR6
30 exanthem 29.8 IL10 ICOSLG CCR6
31 lung disease 29.8 RNASE3 IL5 IL4 IL13 IL10
32 milk allergy 29.7 RNASE3 IL5 IL4 IL13 IL10 IGHE
33 bronchiolitis 29.7 RNASE3 IL5 IL4R IL4 IL13 IL10
34 wheat allergy 29.7 SCP2 PDCL IGHE GHITM COPS7A
35 systemic scleroderma 29.6 IL4 IL13 IL10 ICOSLG CCR6
36 asthma 29.6 RNASE3 NOS1 IL5 IL4R IL4 IL3
37 colitis 29.6 IL4 IL13 IL10 ICOSLG CCR6
38 chronic rhinitis 29.6 RNASE3 IL5 IL4 IL13 GHITM COPS7A
39 esophagitis, eosinophilic, 1 29.5 RNASE3 IL5 IL4 IL3 IL13 ICOSLG
40 dermatitis, atopic 29.5 RNASE3 IL5 IL4R IL4 IL2RB IL13
41 immune deficiency disease 29.4 IL4 IL2RB IL13 IL10 ICOSLG CCR6
42 pulmonary disease, chronic obstructive 29.3 RNASE3 IL5 IL4 IL13 IL10 ICOSLG
43 egg allergy 29.1 PDCL IL5 IL4 IL13 IL10 IGHE
44 inflammatory bowel disease 29.0 IL5 IL4R IL4 IL3 IL2RB IL13
45 chloramine t respiratory allergy 11.6
46 remazole black respiratory allergy 11.4
47 4-vinylcyclohexene dioxide respiratory allergy 11.4
48 acid anhydride respiratory allergy 11.3
49 rare allergic respiratory disease 11.1
50 aztreonam allergy 10.4 IL5 IL13

Graphical network of the top 20 diseases related to Respiratory Allergy:



Diseases related to Respiratory Allergy

Symptoms & Phenotypes for Respiratory Allergy

MGI Mouse Phenotypes related to Respiratory Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.23 IL10 IL2RB IL4 IL4R IL5 NOS1

Drugs & Therapeutics for Respiratory Allergy

Drugs for Respiratory Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 3 299-42-3 9294
2
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
3
Pheniramine Approved Phase 3 86-21-5 4761
4
Naphazoline Approved, Investigational Phase 3 835-31-4 4436
5
Pseudoephedrine Approved Phase 3 90-82-4 7028
6
Maleic acid Experimental Phase 3 110-16-7 444266
7 Anti-Allergic Agents Phase 3
8 Adrenergic alpha-Agonists Phase 3
9 Vasoconstrictor Agents Phase 3
10 Respiratory System Agents Phase 3
11 Adrenergic Agents Phase 3
12 Nasal Decongestants Phase 3
13 Histamine Antagonists Phase 3
14
Histamine Phosphate Phase 3 51-74-1 65513
15 Histamine H1 Antagonists Phase 3
16 Neurotransmitter Agents Phase 3
17 Adrenergic Agonists Phase 3
18 Dermatologic Agents Phase 3
19
Pentetic acid Approved Phase 2 67-43-6
20
Edetic Acid Approved, Vet_approved Phase 2 62-33-9, 60-00-4 6049
21 Pharmaceutical Solutions Phase 2
22
Midazolam Approved, Illicit 59467-70-8 4192
23
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
24
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
25
Ketamine Approved, Vet_approved 6740-88-1 3821
26 Anesthetics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Prospective, Multicentric, Superior Efficacy and Safety of Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal Due to Colds or Other Upper Respiratory Allergies Completed NCT01533220 Phase 3 naphazoline hydrocloride;Naphazoline hydrocloride + Pheniramine Maleate + Panthenol
2 A Randomized, Double Blind, Placebo-controlled Study to Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies Completed NCT01788813 Phase 2 GSK2245035;Placebo
3 A Randomized, Double Blind, Placebo-controlled Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies Completed NCT01607372 Phase 2 GSK2245035
4 ANALYSIS OF HEALTH DATA COLLECTED SYSTEMATICALLY BY THREE HOSPITALS FOR THE VALIDATION OF THE CHAPTER "ALLERGY AND HYPERSENSITIVITY" IN THE FUTURE VERSION 11 OF THE WORLD HEALTH ORGANIZATION (WHO) INTERNATIONAL CLASSIFICATION OF DISEASES (CIM) Unknown status NCT03213808
5 Occupational Respiratory Allergies and Gene-environment Interactions Unknown status NCT02879838
6 The Frequency of Emergence Delirium in Children Undergoing Outpatient Anaesthesia for Magnetic Resonance Imaging Completed NCT04816344
7 Comparison Between Local and Imported Skin Prick Testing Result of Rat and Mouse Allergen Extracts in Respiratory Allergy Patients Completed NCT03645161
8 Crustacean Allergy and Sensitization to Dust Mites in Patients With Respiratory Allergy: Clinical Study and Analysis of Common and Peculiar Allergens Completed NCT01634737
9 Evaluation and Validation of Novel Diagnostic Tool for Allergists (AbioSCOPE) in Volunteer Population With Respiratory Allergies Completed NCT03599908
10 Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy Recruiting NCT04750980
11 Tromsø Birch Rust Allergy Study. Allergy to Birch Rust Fungi, a Possible Explanation to Seasonal Airway Allergy During Autumn? A Pilot Study With 30 Patients With Suspected Allergy to Birch Rust and 15 Non-allergic Controls. Recruiting NCT04322838

Search NIH Clinical Center for Respiratory Allergy

Genetic Tests for Respiratory Allergy

Anatomical Context for Respiratory Allergy

The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory Allergy:

19
Respiratory Tract

MalaCards organs/tissues related to Respiratory Allergy:

40
Skin, T Cells, Lymph Node, Breast, B Cells, Eye, Tonsil

Publications for Respiratory Allergy

Articles related to Respiratory Allergy:

(show top 50) (show all 1752)
# Title Authors PMID Year
1
Risk Factors for Olfactory and Gustatory Dysfunctions in Patients with SARS-CoV-2 Infection. 61
33794531 2021
2
The evolution of allergy immunotherapy. 61
33271297 2021
3
Artificial intelligence in the diagnosis of pediatric allergic diseases. 61
33220121 2021
4
Psychological impact of the COVID-19 pandemic on patients with allergic diseases. 61
33520081 2021
5
Cloning, expression and immunological characterisation of Coc n 1, the first major allergen from Coconut pollen. 61
33486354 2021
6
Vulvovaginal candidiasis and current perspectives: new risk factors and laboratory diagnosis by using MALDI TOF for identifying species in primary infection and recurrence. 61
33713006 2021
7
Dust mite-derived protein disulfide isomerase suppresses airway allergy by inducing tolerogenic dendritic cells. 61
33771560 2021
8
COVID-19 Susceptibility in Bronchial Asthma. 61
33242628 2021
9
Functional Examination of the Upper and Lower Airways in Asthma and Respiratory Allergic Diseases: Considerations in the Post-SARS-CoV-2 Era. 61
32540791 2021
10
Modulation of gut immune response by probiotic fermented milk consumption to control IgE in a respiratory allergy model. 61
33573506 2021
11
Allergen immunotherapy and biologics in respiratory allergy: friends or foes? 61
33369567 2021
12
Integrin αvβ6 cooperates with resiquimod to restore antigen-specific immune tolerance in airway allergy. 61
33385440 2021
13
Epithelial cell-derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T-cell differentiation. 61
33539546 2021
14
A case of anaphylactic reaction following oyster mushroom (Pleurotus ostreatus) inhalation. 61
33630827 2021
15
Diagnostic characterization of respiratory allergies by means of a multiplex immunoassay. 61
33179267 2021
16
Forecast for Pollen Allergy: A Review from Field Observation to Modeling and Services in Korea. 61
33228869 2021
17
Maternal and childhood exposure to inorganic arsenic and airway allergy - A 15-Year birth cohort follow-up study. 61
33161204 2021
18
Environmental perceptions, mental performance, and physiological responses of people with respiratory allergies exposed to reduced Indoor Air Quality. 61
33432603 2021
19
Respiratory allergy control by probiotic fermented milk intake: a mouse model from weaning to maturity. 61
33267751 2020
20
Food allergy promotes a Th2/Th17 response that drives house dust mite-induced allergic airway inflammation in humanized mice. 61
32757273 2020
21
Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation. 61
32557721 2020
22
Allergic sensitization to storage dust mites: a prospective study of patients with respiratory allergy. 61
33191715 2020
23
Epidemiological and immunological study of nasal polyposis among allergic patients in Babylon province: Cross-sectional study. 61
33341843 2020
24
Precision Medicine in House Dust Mite-Driven Allergic Asthma. 61
33255966 2020
25
Acute and subacute oral toxicity of deoxynivalenol exposure in a Dermatophagoides farinae induced murine asthma model. 61
33170220 2020
26
Subcutaneous and sublingual allergen-specific immunotherapy: a tale of two routes. 61
32372588 2020
27
Chronic Airway Allergy Induces Pro-Inflammatory Responses in the Brain of Wildtype Mice but Not 3xTgAD Mice. 61
32916195 2020
28
In utero exposure to genistein decreased intranasal house dust mite-induced respiratory allergy in middle-aged male B6C3F1 offspring. 61
32798538 2020
29
The effect of upper respiratory allergy on acute respiratory response to ambient air pollution during physical exercise. 61
32699426 2020
30
The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. 61
32589303 2020
31
Association between biomarkers and house dust mite sublingual immunotherapy in allergic asthma. 61
32557974 2020
32
Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000-2015: a retrospective multicentre study. 61
32003071 2020
33
FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples. 61
32711257 2020
34
Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines. 61
32884611 2020
35
Occupational respiratory allergy to lettuce in lettuce farmers. 61
32542808 2020
36
NSG mice humanized with allergen-specific T-cell lines as in vivo model of respiratory allergy. 61
32145078 2020
37
Microneedle-Mediated Allergen-Specific Immunotherapy for the Treatment of Airway Allergy in Mice. 61
32643940 2020
38
Collagenous colitis in a child induced by chronic respiratory allergy: A case report. 61
32871927 2020
39
Molecular Sensitization Profile to Dermatophagoides pteronyssinus Dust Mite in Portugal. 61
32732183 2020
40
Allergen immunotherapy for respiratory allergy: to what extent can the risk of systemic reactions be reduced? 61
32511028 2020
41
Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy. 61
32703972 2020
42
Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. 61
32333915 2020
43
Summer storms and their effects on the spectrum and quantity of airborne bioparticles in Bratislava, Central Europe. 61
32696086 2020
44
RAPP-children: A new tool for assessing quality of life in patients with asthma and rhinitis. 61
32163631 2020
45
Anaphylaxis after ingestion of dust mite (Dermatophagoides farinae)-contaminated food: A case report. 61
33612801 2020
46
Influence of respiratory allergy and restless sleep on definite sleep bruxism: a cross-sectional clinical study. 61
32193053 2020
47
A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark. 61
31342402 2020
48
Prevalence of rat and mouse sensitization in Asian patients with respiratory allergy. 61
32416665 2020
49
Allergen Immunotherapy for Local Respiratory Allergy. 61
32430550 2020
50
Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors of Long-term Asthma Severity. 61
31958440 2020

Variations for Respiratory Allergy

Expression for Respiratory Allergy

Search GEO for disease gene expression data for Respiratory Allergy.

Pathways for Respiratory Allergy

Pathways related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 RNASE3 NOS3 NOS1 IL5 IL4R IL4
2
Show member pathways
13.62 NOS3 NOS1 IL5 IL4R IL4 IL3
3
Show member pathways
13.36 NOS3 IL5 IL4R IL4 IL3 IL2RB
4
Show member pathways
13.32 IL5 IL4R IL4 IL3 IL2RB IL13
5
Show member pathways
13.24 IL5 IL4R IL4 IL3 IL2RB IL13
6
Show member pathways
12.81 RNASE3 IL5 IL4 IL3 IL13 IL10
7 12.79 IL5 IL4R IL4 IL3 IL2RB IL13
8
Show member pathways
12.58 IL4R IL4 IL10 IGHE ICOSLG
9
Show member pathways
12.56 IL5 IL4R IL4 IL2RB IL13 IL10
10
Show member pathways
12.54 NOS3 IL5 IL4 IL3 IL13 IGHE
11
Show member pathways
12.26 IL5 IL4R IL4 IL3 IL2RB IL13
12
Show member pathways
12.22 IL5 IL4 IL3 IL13 IL10
13 11.96 IL5 IL4 IL3 IL2RB IL10
14 11.93 IL4R IL4 IL13 IL10 IGHE
15 11.86 IL5 IL4R IL4 IL3
16 11.74 IL5 IL4 IL13
17
Show member pathways
11.7 IL5 IL4 IL3
18 11.68 IL4R IL4 IL2RB
19 11.62 IL5 IL4 IL10 ICOSLG CCR6
20 11.61 IL5 IL4 IL13
21
Show member pathways
11.57 NOS3 NOS1 AOC1
22 11.57 IL5 IL4R IL4 IL10 IGHE
23 11.54 IL5 IL4 IL2RB IL13 IL10 CCR6
24 11.48 IL4 IL13 IL10
25 11.28 IL5 IL4 IL13
26 11.28 IL5 IL4R IL4 IL2RB
27 11.15 IL5 IL4 IL13 IL10
28 10.96 IL5 IL4 IL3 IL13 IL10
29 10.82 IL5 IL4 IL3 IL13 IL10
30 10.77 NOS3 NOS1
31 10.76 IL5 IL4R IL4 IL2RB IL13 IL10
32 10.64 IL5 IL4R IL4 IL13
33 10.54 NOS3 NOS1

GO Terms for Respiratory Allergy

Cellular components related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 RNASE3 IL5 IL4R IL4 IL3 IL13
2 extracellular region GO:0005576 9.61 RNASE3 IL5 IL4R IL4 IL3 IL13
3 external side of plasma membrane GO:0009897 9.02 IL2RB IL13 IGHE ICOSLG CCR6

Biological processes related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.8 NOS3 NOS1 IL13 IL10
2 immune response GO:0006955 9.76 IL5 IL4R IL4 IL3 IL13 IL10
3 positive regulation of cold-induced thermogenesis GO:0120162 9.74 IL4R IL4 IL13
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 IL4 IL3 IL13
5 positive regulation of B cell proliferation GO:0030890 9.63 IL5 IL4 IL13
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 IL4 IL13 IL10
7 macrophage activation GO:0042116 9.56 IL4 IL13
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.55 IL4 IL10
9 positive regulation of guanylate cyclase activity GO:0031284 9.54 NOS3 NOS1
10 arginine catabolic process GO:0006527 9.51 NOS3 NOS1
11 positive regulation of macrophage activation GO:0043032 9.5 IL4R IL13 IL10
12 type 2 immune response GO:0042092 9.48 IL4 IL10
13 positive regulation of mast cell degranulation GO:0043306 9.43 IL4R IL4 IL13
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL4 IL13
15 regulation of isotype switching GO:0045191 9.37 IL4 IL10
16 positive regulation of immunoglobulin production GO:0002639 9.26 IL5 IL4R IL13 IL10
17 cytokine-mediated signaling pathway GO:0019221 9.23 IL5 IL4R IL4 IL3 IL2RB IL13

Molecular functions related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL5 IL4 IL3 IL10
2 arginine binding GO:0034618 9.4 NOS3 NOS1
3 NADPH-hemoprotein reductase activity GO:0003958 9.37 NOS3 NOS1
4 cadmium ion binding GO:0046870 9.32 NOS3 NOS1
5 tetrahydrobiopterin binding GO:0034617 9.16 NOS3 NOS1
6 cytokine activity GO:0005125 9.02 IL5 IL4 IL3 IL13 IL10
7 nitric-oxide synthase activity GO:0004517 8.96 NOS3 NOS1

Sources for Respiratory Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....