MCID: RSP021
MIFTS: 48

Respiratory Allergy

Categories: Immune diseases

Aliases & Classifications for Respiratory Allergy

MalaCards integrated aliases for Respiratory Allergy:

Name: Respiratory Allergy 12 15
Airway Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060496

Summaries for Respiratory Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease located in the respiratory tract.

MalaCards based summary : Respiratory Allergy, also known as airway allergy, is related to pollen allergy and sinusitis. An important gene associated with Respiratory Allergy is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ephedrine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Respiratory Allergy

Diseases related to Respiratory Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.1 IL13 IL3 IL4R IL5 RNASE3
2 sinusitis 30.2 IL4R IL5 RNASE3
3 egg allergy 30.0 IGHE IL4 IL5
4 food allergy 30.0 IL13 IL4 IL5 MS4A2 RNASE3 STAT6
5 rhinitis 29.9 CCL11 IGHE IL13 IL4 IL4R IL5
6 dermatitis 29.9 CCL11 IGHE IL13 IL4 IL5 TLR9
7 otitis media 29.8 CCL11 IGHE IL4 RNASE3
8 esophagitis 29.8 CCL11 IL13 IL5 TSLP
9 pneumonia 29.8 CCL11 IL13 IL5 TLR9
10 allergic rhinitis 29.7 CCL11 IGHE IL13 IL4 IL4R IL5
11 esophagitis, eosinophilic, 1 29.6 CCL11 IL13 IL5 STAT6 TSLP
12 ige responsiveness, atopic 29.5 IGHE IL13 IL4 IL4R IL5 MS4A2
13 asthma 29.4 CCL11 GATA3 IGHE IL13 IL3 IL4
14 inflammatory bowel disease 29.4 CCL11 IL13 IL4 IL4R IL5 STAT6
15 common cold 29.3 CCL11 IL13 IL33 IL5 RNASE3 TLR9
16 dermatitis, atopic 29.0 CCL11 GATA3 IGHE IL13 IL4 IL4R
17 chloramine t respiratory allergy 12.5
18 remazole black respiratory allergy 12.4
19 4-vinylcyclohexene dioxide respiratory allergy 12.4
20 acid anhydride respiratory allergy 12.3
21 cytokine deficiency 10.3 IL13 IL5
22 loeffler endocarditis 10.3 IL5 RNASE3
23 seborrheic infantile dermatitis 10.3 IL3 IL5
24 papillary conjunctivitis 10.3 CCL11 IL4
25 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
26 virus associated hemophagocytic syndrome 10.3 IL2RB IL4
27 cough variant asthma 10.3 IL4 IL5 RNASE3
28 apple allergy 10.3 IL13 IL4 IL5
29 toxic oil syndrome 10.3 IGHE IL4 IL5
30 paragonimiasis 10.2 IL13 IL5 RNASE3
31 respiratory syncytial virus infectious disease 10.2 IL13 IL5
32 chronic tic disorder 10.2 IL13 IL4 IL5
33 pemphigoid gestationis 10.2 CCL11 IL5
34 b-cell growth factor 10.2 IL3 IL4
35 enterobiasis 10.2 IL13 IL4 IL5
36 hyper ige syndrome 10.2 IGHE IL4 IL4R
37 milk allergy 10.2 IL4 IL5 RNASE3
38 cow milk allergy 10.2 IL5 RNASE3
39 scleritis 10.2 IL4 IL5
40 allergic contact dermatitis 10.2 IL33 IL4 IL5
41 filarial elephantiasis 10.2 IL4 IL5 TLR9
42 blepharoconjunctivitis 10.2 CCL11 IL4 RNASE3
43 strongyloidiasis 10.2 CCL11 IL13 IL5
44 giant papillary conjunctivitis 10.2 CCL11 IL4 RNASE3
45 folliculitis 10.2 CCL11 IL4 IL5
46 chronic eosinophilic pneumonia 10.2 CCL11 IL5 RNASE3
47 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL13 IL5 TLR9
48 tetanus 10.2 IL13 IL4 IL5
49 omenn syndrome 10.2 IGHE IL4 IL5
50 yellow fever 10.2 IL4 IL5 TLR9

Graphical network of the top 20 diseases related to Respiratory Allergy:



Diseases related to Respiratory Allergy

Symptoms & Phenotypes for Respiratory Allergy

MGI Mouse Phenotypes related to Respiratory Allergy:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 CCL11 GATA3 IL13 IL2RB IL33 IL4
2 homeostasis/metabolism MP:0005376 10.28 FLNC GATA3 IL13 IL33 IL4 IL4R
3 immune system MP:0005387 10.25 CCL11 GATA3 IL13 IL2RB IL33 IL4
4 growth/size/body region MP:0005378 10.22 FLNC GATA3 IL13 IL2RB IL4 IL4R
5 digestive/alimentary MP:0005381 10.21 GATA3 IL13 IL33 IL4 IL4R IL5
6 endocrine/exocrine gland MP:0005379 10.15 GATA3 IL13 IL2RB IL33 IL4 IL4R
7 mortality/aging MP:0010768 10.03 FLNC GATA3 IL13 IL2RB IL33 IL4
8 integument MP:0010771 10.02 FLNC GATA3 IL13 IL2RB IL33 IL4
9 liver/biliary system MP:0005370 9.87 IL2RB IL4 IL4R IL5 NOS1 NOS3
10 renal/urinary system MP:0005367 9.7 GATA3 IL4 NOS1 NOS3 PDC STAT6
11 reproductive system MP:0005389 9.61 GATA3 IL13 IL2RB IL33 IL4 IL5
12 respiratory system MP:0005388 9.36 CCL11 FLNC IL13 IL33 IL4 IL4R

Drugs & Therapeutics for Respiratory Allergy

Drugs for Respiratory Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 3,Phase 1 299-42-3 9294
2
Histamine Approved, Investigational Phase 3,Phase 1 51-45-6, 75614-87-8 774
3
Pheniramine Approved Phase 3 86-21-5 4761
4
Naphazoline Approved, Investigational Phase 3 835-31-4 4436
5
Pseudoephedrine Approved Phase 3,Phase 1 90-82-4 7028
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
Pantothenic acid Approved, Nutraceutical, Vet_approved Phase 3 79-83-4 988
8
Maleic acid Experimental Phase 3 110-16-7 444266
9 Vitamin B Complex Phase 3
10 Vasoconstrictor Agents Phase 3,Phase 1
11 Histamine Antagonists Phase 3,Phase 1
12
Histamine Phosphate Phase 3,Phase 1 51-74-1 65513
13 Vitamin B9 Phase 3
14 Vitamins Phase 3
15 Trace Elements Phase 3
16 Nasal Decongestants Phase 3,Phase 1
17 Anti-Allergic Agents Phase 3,Phase 1
18 Adrenergic alpha-Agonists Phase 3
19 Adrenergic Agonists Phase 3
20 Adrenergic Agents Phase 3,Phase 1
21 Dermatologic Agents Phase 3,Phase 1
22 Respiratory System Agents Phase 3,Phase 1
23 Histamine H1 Antagonists Phase 3,Phase 1
24 Antipruritics Phase 3,Phase 1
25 Folate Phase 3
26 Neurotransmitter Agents Phase 3,Phase 1
27 Micronutrients Phase 3
28
Pentetic acid Approved Phase 2 67-43-6
29
Edetic Acid Approved, Vet_approved Phase 2 62-33-9, 60-00-4 6049
30 Pharmaceutical Solutions Phase 2
31 Bifidobacterium Phase 1, Phase 2
32 Acidophilus Phase 1, Phase 2,Not Applicable
33 Immunologic Factors Phase 2
34 Antibodies Phase 2
35 Antibodies, Monoclonal Phase 2
36 Immunoglobulins Phase 2
37
Loratadine Approved, Investigational Phase 1 79794-75-5 3957
38 Anti-Asthmatic Agents Phase 1
39 Histamine H1 Antagonists, Non-Sedating Phase 1
40 Central Nervous System Stimulants Phase 1
41 Bronchodilator Agents Phase 1
42 Sympathomimetics Phase 1
43 Peripheral Nervous System Agents Phase 1
44 Autonomic Agents Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Sublingual Immunotherapy In Alternaria-Induced Rhinitis Completed NCT01127035 Phase 4
2 Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal Completed NCT01533220 Phase 3 naphazoline hydrocloride;Naphazoline hydrocloride + Pheniramine Maleate + Panthenol
3 A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies Completed NCT01607372 Phase 2 GSK2245035
4 To Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of the Toll-like Receptor 7 (TLR7) Agonist GSK2245035 in Subjects With Respiratory Allergies Completed NCT01788813 Phase 2 GSK2245035;Placebo
5 Probiotics for Birch Pollen Allergy Completed NCT00746226 Phase 1, Phase 2
6 Follow-up Study to Investigate the Effect of GSK2245035 on Nasal Allergic Reactivity in Subjects Completing Treatment in Study TL7116958 Completed NCT02446613 Phase 2
7 A Study of Lebrikizumab (RO5490255) in Participants With Severe Oral Corticosteroids (OCS) Dependent Asthma Completed NCT01987492 Phase 2 Lebrikizumab;Placebo
8 A Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis Recruiting NCT03142191 Phase 2 CC-90001
9 Safety and Efficacy of Low-dose IL-2 in Allergy to Birch Pollen Not yet recruiting NCT03776643 Phase 2 ILT-101 ld-(IL2)
10 A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufactuers Under Fed Conditions in Healthy Adult Subjects Completed NCT03517943 Phase 1 Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-SAG);Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-Heist)
11 A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufacturers Under Fasted Conditions in Healthy Adult Subjects Completed NCT03517930 Phase 1 Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-SAG);Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-Heist)
12 Evaluation of Immunological Changes and Clinical Efficacy of Specific Immunotherapy With Der p House Dust Mite Allergen in Polysensitized and Monosensitized Patients With Allergic Rhinitis and/or Asthma. Unknown status NCT01795846
13 Crustacean Allergy and Dust Mites Sensitization Completed NCT01634737
14 Evaluation and Validation of Novel Diagnostic Tool for Allergists (AbioSCOPE) Completed NCT03599908
15 Influence of Probiotics on Atopy With Focus on Respiratory Allergic Diseases- Follow-up to 7 Years Completed NCT00826189
16 Probiotics for Reduction Of Markers In Subjects With Allergy Completed NCT01137357 Not Applicable
17 Oral Allergy Syndrome (OAS): a Pilot Study to Evaluate a Clinical Questionnaire as a Diagnostic Tool Completed NCT00427479
18 Systemic Reactions to Allergen Immunotherapy Amd Skin Testing Completed NCT00594802
19 Comparison Between Local and Imported Skin Prick Testing Result of Rat and Mouse Allergen Extracts Recruiting NCT03645161 Not Applicable
20 Molekule for Allergic Rhinitis/Asthma Recruiting NCT03627689 Not Applicable
21 VALIDATION OF THE CHAPTER "ALLERGIES AND HYPERSENSITIVITY" OF THE INTERNATIONAL DISEASE CLASSIFICATION (CIM) Recruiting NCT03213808
22 Probiotics in Prevention of Allergies, Obesity and Caries Active, not recruiting NCT00894816 Not Applicable
23 Occupational Respiratory Allergies and Gene-environment Interactions Not yet recruiting NCT02879838

Search NIH Clinical Center for Respiratory Allergy

Genetic Tests for Respiratory Allergy

Anatomical Context for Respiratory Allergy

MalaCards organs/tissues related to Respiratory Allergy:

41
Testes, Skin, Lung, Lymph Node, Eye, Tonsil, T Cells

Publications for Respiratory Allergy

Articles related to Respiratory Allergy:

(show top 50) (show all 495)
# Title Authors Year
1
Effects of Respiratory Syncytial Virus Infection in Infancy on Asthma and Respiratory Allergy in 6-Year-Old Children. ( 30392008 )
2018
2
Latest News on relationship between thunderstorms and respiratory allergy, severe asthma, and deaths for asthma. ( 30242857 )
2018
3
Early food allergy and respiratory allergy symptoms and attention-deficit/hyperactivity disorder in Chinese children: A cross-sectional study. ( 29524252 )
2018
4
Molecular diagnostics improves diagnosis and treatment of respiratory allergy and food allergy with economic optimization and cost saving. ( 30245286 )
2018
5
Impact of increasing treatment rates on cost-effectiveness of subcutaneous immunotherapy (SCIT) in respiratory allergy: a decision analytic modelling approach. ( 29574666 )
2018
6
GLI2 promoter hypermethylation in saliva of children with a respiratory allergy. ( 29682088 )
2018
7
Biomarkers of respiratory allergy in laboratory animal care workers: an observational study. ( 29858653 )
2018
8
Cosensitization to profilin is associated with less severe reactions to foods in nsLTPs and storage proteins reactors and with less severe respiratory allergy. ( 29885248 )
2018
9
Sublingual immunotherapy of house dust mite respiratory allergy in China. ( 29921463 )
2018
10
Multi-omics analysis points to altered platelet functions in severe food-associated respiratory allergy. ( 30028518 )
2018
11
IgE Test in Secretions of Patients with Respiratory Allergy. ( 30317418 )
2018
12
Sublingual allergen immunotherapy for respiratory allergy: a systematic review. ( 30416528 )
2018
13
The economic advantage of allergen immunotherapy over drug treatment in respiratory allergy. ( 29295630 )
2018
14
Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy. ( 29339772 )
2018
15
Probiotics against airway allergy: host factors to consider. ( 30037806 )
2018
16
Coated microneedle-based cutaneous immunotherapy prevents Der p 1-induced airway allergy in mice. ( 30171871 )
2018
17
Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization. ( 30227178 )
2018
18
Unravelling the apoptotic mechanisms in T-lymphocytes in an animal model for pollen induced airway allergy and studying the impact of specific immunotherapy. ( 30471949 )
2018
19
Primary Prevention of Airway Allergy. ( 30524932 )
2018
20
Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence. ( 29221963 )
2017
21
Occurrence of COPD in Patients with Respiratory Allergy: A Clinico-Spirometric Evaluation in a Tertiary Hospital, Kolkata. ( 28658755 )
2017
22
Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy. ( 27376923 )
2017
23
RHINASTHMA-Children: A new quality of life tool for patients with respiratory allergy. ( 27732756 )
2017
24
Respiratory allergy buzz on the Internet. ( 27765462 )
2017
25
The dangerous liaison between pollens and pollution in respiratory allergy. ( 28143681 )
2017
26
Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy. ( 28270741 )
2017
27
Evaluation of a sublingual immunotherapy solution in olive-induced respiratory allergy in Jordan: a retrospective observational study. ( 28280371 )
2017
28
Occupational respiratory allergy in peach crop workers. ( 28317175 )
2017
29
Allergen-Specific Immunotherapy for Respiratory Allergy in Children: Unmet Needs and Future Goals. ( 28389302 )
2017
30
Searching online for health-related information by people suffering from respiratory allergy and asthma: the results of a survey study. ( 28440534 )
2017
31
Correction: Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy. ( 28787008 )
2017
32
The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways. ( 28813677 )
2017
33
Course of respiratory allergy by treatment strategy based on German routine data. ( 29034146 )
2017
34
Tablet-based sublingual immunotherapy for respiratory allergy. ( 29146015 )
2017
35
Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy. ( 29199961 )
2017
36
IgE-Binding Aldolases From Artemia and Mysis Species Causing Respiratory Allergy to Aquarium Fish Food. ( 29199968 )
2017
37
Dust mite allergen, glutathione S-transferase, induces T cell immunoglobulin mucin domain-4 in dendritic cells to facilitate initiation of airway allergy. ( 27532130 )
2017
38
Role of the Allergist-Immunologist and Upper Airway Allergy in Sleep-Disordered Breathing. ( 27923646 )
2017
39
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model. ( 28240301 )
2017
40
Modulation of regulatory T cells by intranasal allergen immunotherapy in an experimental rat model of airway allergy. ( 28349869 )
2017
41
Cutaneous vaccination with coated microneedles prevents development of airway allergy. ( 28821461 )
2017
42
Using a CD45dim/CD123bright/HLA-DRneg phenotyping protocol to gate basophils in FC for airway allergy. CD123 does not decrease. ( 28871586 )
2017
43
Significant upregulation of cytokine secretion from T helper type 9 and 17 cells in a NC/Nga mouse model of ambient chemical exposure-induced respiratory allergy. ( 27095298 )
2016
44
The efficiency of peptide immunotherapy for respiratory allergy. ( 26901667 )
2016
45
Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy. ( 26999364 )
2016
46
Is There any Relationship Between Extra-Pulmonary Manifestations of Mycoplasma Pneumoniae Infection and Atopy/Respiratory Allergy in Children? ( 27114818 )
2016
47
Alternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy. ( 26826364 )
2016
48
Randomized dose-response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in patients with respiratory allergy. ( 26757045 )
2016
49
Asthma and respiratory allergy prevalence is still increasing among Finnish young adults. ( 26677942 )
2016
50
Climate Change and Air Pollution: Effects on Respiratory Allergy. ( 27334776 )
2016

Variations for Respiratory Allergy

Expression for Respiratory Allergy

Search GEO for disease gene expression data for Respiratory Allergy.

Pathways for Respiratory Allergy

Pathways related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CCL11 GATA3 IGHE IL13 IL2RB IL3
2
Show member pathways
13.66 CCL11 IL13 IL2RB IL3 IL33 IL4
3
Show member pathways
13.5 CCL11 IL13 IL2RB IL3 IL4 IL4R
4
Show member pathways
13.4 CCL11 IL13 IL2RB IL3 IL4 IL4R
5
Show member pathways
13.3 CCL11 FLNC IL13 IL2RB IL3 IL4
6
Show member pathways
13.28 CCL11 GATA3 IGHE IL13 IL2RB IL3
7
Show member pathways
12.87 CCL11 IL13 IL3 IL4 IL4R IL5
8 12.83 IL13 IL2RB IL3 IL4 IL4R IL5
9
Show member pathways
12.74 IL13 IL2RB IL33 IL4 TLR9
10 12.57 GATA3 IL2RB IL3 IL4 STAT6 TLR9
11
Show member pathways
12.56 GATA3 IL13 IL2RB IL4 IL4R IL5
12
Show member pathways
12.53 IGHE IL13 IL3 IL4 IL5 MS4A2
13
Show member pathways
12.41 CCL11 GATA3 IGHE IL4 IL4R STAT6
14
Show member pathways
12.34 IL13 IL2RB IL3 IL4 IL4R IL5
15
Show member pathways
12.28 CCL11 IL13 IL4 IL5
16
Show member pathways
12.07 CCL11 IL13 IL2RB IL3 IL4 IL4R
17 12 IL2RB IL3 IL4 IL5
18
Show member pathways
11.9 IL2RB IL4 STAT6
19 11.9 IL3 IL4 IL4R IL5
20 11.88 IL2RB IL3 IL4R STAT6
21 11.86 CCL11 GATA3 IGHE IL13 IL4 IL4R
22 11.83 GATA3 IL13 IL4 IL5
23
Show member pathways
11.79 GATA3 IL3 IL4 IL5
24 11.69 CCL11 IL13 IL4 IL5
25 11.68 CCL11 IL13 IL4
26 11.6 CCL11 IGHE IL4 IL4R IL5 STAT6
27 11.6 GATA3 IL13 IL2RB IL33 IL4 IL5
28 11.49 CCL11 STAT6 TSLP
29 11.36 IL2RB IL4 IL4R IL5
30 11.26 IL13 IL3 IL4 IL5
31 11.23 CCL11 IL13 IL3 IL4 IL5
32 11.21 IL13 IL4 IL5
33 10.97 CCL11 IL13 IL3 IL4 IL5
34 10.94 GATA3 IL13 IL33 IL4 IL5 TSLP
35 10.94 CCL11 GATA3 IL13 IL2RB IL33 IL4
36 10.78 NOS1 NOS3
37 10.55 NOS1 NOS3

GO Terms for Respiratory Allergy

Cellular components related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL11 IL13 IL3 IL33 IL4 IL4R
2 extracellular region GO:0005576 9.36 CCL11 IGHE IL13 IL3 IL33 IL4

Biological processes related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.96 CCL11 IL13 IL5 MS4A2 TLR9
2 positive regulation of gene expression GO:0010628 9.95 GATA3 IL13 IL33 IL4 NOS3 TLR9
3 regulation of signaling receptor activity GO:0010469 9.87 CCL11 IL13 IL3 IL33 IL4 IL5
4 positive regulation of cold-induced thermogenesis GO:0120162 9.8 IL13 IL4 IL4R STAT6
5 positive regulation of inflammatory response GO:0050729 9.79 IL33 TLR9 TSLP
6 positive regulation of interleukin-6 production GO:0032755 9.77 IL33 TLR9 TSLP
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IL13 IL3 IL4 TSLP
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.71 GATA3 IL13 IL4
9 regulation of sodium ion transport GO:0002028 9.65 NOS1 NOS3
10 nitric oxide mediated signal transduction GO:0007263 9.65 NOS1 NOS3
11 embryonic hemopoiesis GO:0035162 9.65 GATA3 IL3
12 negative regulation of calcium ion transport GO:0051926 9.64 NOS1 NOS3
13 nitric oxide biosynthetic process GO:0006809 9.64 NOS1 NOS3
14 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL33 IL5
15 positive regulation of macrophage activation GO:0043032 9.63 IL13 IL33 IL4R
16 positive regulation of chemokine secretion GO:0090197 9.62 IL33 IL4R
17 negative regulation of potassium ion transport GO:0043267 9.61 NOS1 NOS3
18 positive regulation of guanylate cyclase activity GO:0031284 9.61 NOS1 NOS3
19 immune response GO:0006955 9.61 CCL11 IGHE IL13 IL3 IL4 IL4R
20 positive regulation of mast cell degranulation GO:0043306 9.6 IL13 IL4R
21 arginine catabolic process GO:0006527 9.58 NOS1 NOS3
22 negative regulation of hydrolase activity GO:0051346 9.58 NOS1 NOS3
23 positive regulation of immunoglobulin production GO:0002639 9.58 IL13 IL4R TLR9
24 positive regulation of interleukin-5 secretion GO:2000664 9.57 GATA3 TSLP
25 positive regulation of B cell proliferation GO:0030890 9.56 IL13 IL4 IL5 TLR9
26 interleukin-4-mediated signaling pathway GO:0035771 9.55 IL4R STAT6
27 positive regulation of interleukin-5 production GO:0032754 9.54 GATA3 IL33 TSLP
28 negative regulation of complement-dependent cytotoxicity GO:1903660 9.52 IL13 IL4
29 positive regulation of isotype switching to IgE isotypes GO:0048295 9.51 IL4 STAT6
30 positive regulation of interleukin-13 production GO:0032736 9.46 GATA3 IL33 IL4 TSLP
31 cytokine-mediated signaling pathway GO:0019221 9.32 CCL11 GATA3 IGHE IL13 IL2RB IL3
32 signal transduction GO:0007165 10.23 CCL11 GATA3 IL2RB IL4R MS4A2 PDCL

Molecular functions related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.61 IL2RB IL3 IL5
2 FMN binding GO:0010181 9.4 NOS1 NOS3
3 arginine binding GO:0034618 9.37 NOS1 NOS3
4 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS1 NOS3
5 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
6 cytokine activity GO:0005125 9.17 CCL11 IL13 IL3 IL33 IL4 IL5
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS1 NOS3
8 nitric-oxide synthase activity GO:0004517 8.96 NOS1 NOS3

Sources for Respiratory Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....