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MCID: RSP021
MIFTS: 45

Respiratory Allergy

Categories: Immune diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Respiratory Allergy

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MalaCards integrated aliases for Respiratory Allergy:

Name: Respiratory Allergy 12 15
Airway Allergy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060496
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Summaries for Respiratory Allergy

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Disease Ontology : 12 An allergic hypersensitiity disease located in the respiratory tract.

MalaCards based summary : Respiratory Allergy, also known as airway allergy, is related to pollen allergy and ige responsiveness, atopic. An important gene associated with Respiratory Allergy is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Histamine and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and skin, and related phenotypes are digestive/alimentary and growth/size/body region

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Related Diseases for Respiratory Allergy

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Diseases related to Respiratory Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.9 RNASE3 PDCL IL5 IL4R IL3 IL13
2 ige responsiveness, atopic 31.6 RNASE3 IL5 IL4R IL4 IL13 IL10
3 allergic rhinitis 31.5 RNASE3 IL5 IL4R IL4 IL17A IL13
4 rhinitis 31.3 TSLP RNASE3 IL5 IL4R IL4 IL33
5 conjunctivitis 31.0 RNASE3 IL5 IL4 IL33 IL13 IL10
6 urticaria 31.0 RNASE3 IL5 IL4 IL13 IL10 AOC1
7 food allergy 31.0 RNASE3 IL5 IL4R IL4 IL17A IL13
8 bronchitis 31.0 RNASE3 IL5 IL4 IL13 IL10 CCL11
9 allergic asthma 30.9 TSLP RNASE3 IL5 IL4R IL4 IL3
10 cytokine deficiency 30.7 IL5 IL13
11 allergic conjunctivitis 30.7 RNASE3 IL5 IL4 IL33 IL13 IL10
12 dermatitis 30.7 TSLP IL5 IL4 IL2RB IL17A IL13
13 hypereosinophilic syndrome 30.6 RNASE3 IL5 IL4 IL3 IL13 IL10
14 cough variant asthma 30.6 RNASE3 IL5 IL4 IL13
15 erythema multiforme 30.6 IL5 IL4 IL13
16 lung disease 30.6 RNASE3 IL5 IL4 IL17A IL13 IL10
17 cow milk allergy 30.5 RNASE3 IL5 IL4 IL10
18 contact dermatitis 30.5 IL5 IL4 IL33 IL17A IL10 CD4
19 chronic rhinitis 30.5 RNASE3 IL5 IL4 IL33 IL13
20 diphtheria 30.5 IL5 IL4 IL3 IL2RB IL13
21 tetanus 30.5 IL5 IL4 IL13 IL10
22 candidiasis 30.4 IL4 IL17A IL10 CCR6
23 milk allergy 30.4 RNASE3 IL5 IL4 IL13 IL10
24 chlamydia 30.4 IL5 IL4 IL17A IL10
25 oral candidiasis 30.4 IL17A CD4 CCR6
26 allergic contact dermatitis 30.4 IL5 IL4 IL33 IL17A IL10 CD4
27 exanthem 30.4 IL10 ICOSLG CD4 CCR6
28 proteasome-associated autoinflammatory syndrome 1 30.4 RNASE3 IL5 IL4 IL17A IL13 IL10
29 otitis media 30.4 RNASE3 IL5 IL4 IL17A IL13 IL10
30 ulcerative colitis 30.4 IL4 IL17A IL13 IL10 CCR6
31 esophagitis 30.2 TSLP IL5 IL4 IL33 IL13 IL10
32 hyper ige syndrome 30.1 IL4R IL4 IL17A IL13 IL10 CCR6
33 immune deficiency disease 30.1 IL4 IL2RB IL13 IL10 ICOSLG CD4
34 systemic scleroderma 30.0 IL4 IL17A IL13 IL10 ICOSLG CD4
35 bronchiolitis 30.0 RNASE3 IL5 IL4R IL4 IL17A IL13
36 toxoplasmosis 30.0 IL5 IL4 IL10
37 egg allergy 30.0 TSLP PDCL IL5 IL4 IL13 IL10
38 parasitic protozoa infectious disease 30.0 IL5 IL4 IL17A IL13 IL10 ICOSLG
39 dermatitis, atopic 29.9 TSLP RNASE3 IL5 IL4R IL4 IL33
40 esophagitis, eosinophilic, 1 29.9 TSLP RNASE3 IL5 IL4 IL33 IL3
41 allergic hypersensitivity disease 29.9 TSLP RNASE3 IL5 IL4R IL4 IL33
42 asthma 29.7 TSLP RNASE3 NOS1 IL5 IL4R IL4
43 pulmonary disease, chronic obstructive 29.7 RNASE3 IL5 IL4 IL17A IL13 IL10
44 inflammatory bowel disease 29.5 IL5 IL4R IL4 IL33 IL3 IL2RB
45 common cold 29.4 TSLP RNASE3 IL5 IL4 IL33 IL17A
46 chloramine t respiratory allergy 12.6
47 remazole black respiratory allergy 12.5
48 4-vinylcyclohexene dioxide respiratory allergy 12.5
49 acid anhydride respiratory allergy 12.5
50 rare allergic respiratory disease 11.3

Graphical network of the top 20 diseases related to Respiratory Allergy:



Diseases related to Respiratory Allergy
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Symptoms & Phenotypes for Respiratory Allergy

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MGI Mouse Phenotypes related to Respiratory Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.26 CD4 GLI2 IL10 IL13 IL17A IL33
2 growth/size/body region MP:0005378 10.25 CD4 GLI2 IL10 IL13 IL17A IL2RB
3 hematopoietic system MP:0005397 10.25 CCL11 CCR6 CD4 IL10 IL13 IL17A
4 homeostasis/metabolism MP:0005376 10.21 CCR6 CD4 GLI2 IL10 IL13 IL17A
5 endocrine/exocrine gland MP:0005379 10.2 CD4 GLI2 IL10 IL13 IL17A IL2RB
6 immune system MP:0005387 10.17 CCL11 CCR6 CD4 IL10 IL13 IL17A
7 integument MP:0010771 9.96 CD4 GLI2 IL10 IL13 IL17A IL2RB
8 nervous system MP:0003631 9.9 CCR6 CD4 GLI2 IL10 IL13 IL33
9 no phenotypic analysis MP:0003012 9.56 CD4 GLI2 IL10 IL13 IL17A IL33
10 respiratory system MP:0005388 9.4 CCL11 GLI2 IL10 IL13 IL17A IL33
Sources

Drugs & Therapeutics for Respiratory Allergy

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Drugs for Respiratory Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Fexofenadine Approved, Investigational Phase 3 83799-24-0 3348
3
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
4
Montelukast Approved Phase 3 158966-92-8 5281040
5 Anti-Allergic Agents Phase 3
6 Respiratory System Agents Phase 3
7 Histamine H1 Antagonists Phase 3
8 Histamine H1 Antagonists, Non-Sedating Phase 3
9 Histamine Antagonists Phase 3
10 Dermatologic Agents Phase 3
11
Histamine Phosphate Phase 3 51-74-1 65513
12 Anti-Asthmatic Agents Phase 3
13 Neurotransmitter Agents Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Hormones Phase 3
16 Hormone Antagonists Phase 3
17 Leukotriene Antagonists Phase 3
18
Epinephrine Approved, Vet_approved Phase 1, Phase 2 51-43-4 5816
19
Racepinephrine Approved Phase 1, Phase 2 329-65-7 838
20
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
21 Acidophilus Phase 1, Phase 2
22 Bifidobacterium Phase 1, Phase 2
23 Adrenergic Agents Phase 1, Phase 2
24 Vasoconstrictor Agents Phase 1, Phase 2
25 Sympathomimetics Phase 1, Phase 2
26 Bronchodilator Agents Phase 1, Phase 2
27 Adrenergic alpha-Agonists Phase 1, Phase 2
28 Adrenergic beta-Agonists Phase 1, Phase 2
29 Epinephryl borate Phase 1, Phase 2
30 Adrenergic Agonists Phase 1, Phase 2
31 Mydriatics Phase 1, Phase 2
32 Anti-Bacterial Agents Phase 2
33 Anti-Infective Agents Phase 2
34
Pseudoephedrine Approved Phase 1 90-82-4 7028
35
Ephedrine Approved Phase 1 299-42-3 9294
36
Loratadine Approved, Investigational Phase 1 79794-75-5 3957
37 Central Nervous System Stimulants Phase 1
38 Nasal Decongestants Phase 1
39
Menthol Approved 2216-51-5 16666
40 Trace Elements
41 Nutrients
42
Nickel 7440-02-0 934
43 Micronutrients
44 glucocorticoids
45
Beclomethasone 4419-39-0 20469

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 STUDIO IN DOPPIO CIECO DISODIOCROMOGLICATO + PLACEBO vs DISODIOCROMOGLICATO + IMMUNOTERAPIA SPECIFICA SUBLINGUALE PER ALTERNARIA IN PAZIENTI CON RINITE ALLERGICA DOVUTA A SENSIBILIZZAZIONE AD ALTERNARIA Completed NCT01127035 Phase 4
2 A Multicenter, Double-Blind, Randomized, Parallel Groups Placebo-Controlled Study to Assess the Efficacy and Safety of Fexofenadine 120mg BID in Subjects With Mild to Moderate Persistent Asthma Completed NCT00044811 Phase 3 Fexofenadine
3 An Exploratory Study of Mometasone Furoate Nasal Spray in Patients With Moderate-severe Persistent Allergic Rhinitis and Intermittent Asthma: Effects on the Quality of Life Evaluated With the Rhinasthma Questionnaire Completed NCT00599027 Phase 3 Mometasone furoate nasal spray (MFNS);Placebo nasal spray
4 A Multicenter, Double-Blind, Randomized, Parallel Groups Placebo-Controlled Study to Assess the Efficacy and Safety of Fexofenadine 120mg BID in Subjects With Mild to Moderate Persistent Asthma Completed NCT00044824 Phase 3 Fexofenadine
5 A Multicenter, Open-Label, Randomized, Parallel Groups Study to Assess the Long-Term Safety Performance of Fexofenadine Compared to Montelukast in Subjects With Asthma Completed NCT00045955 Phase 3 Fexofenadine, Comparator = Montelukast
6 Probiotic Intervention for Children With Birch Pollen Allergy Completed NCT00746226 Phase 1, Phase 2
7 A Single-centre, Follow-up Study to Investigate the Effect of GSK2245035 on Nasal Allergic Reactivity in Subjects Who Completed Treatment in Study TL7116958 in 2014 Completed NCT02446613 Phase 2
8 Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction? Completed NCT03963115 Phase 1, Phase 2 Epinephrine or normal saline
9 Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline Active, not recruiting NCT04202263 Phase 2 Minocycline Topical;Placebos
10 A Randomized, Crossover Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D® 12-Hour Extended Release Tablet (Loratadine 5mg/Pseudoephedrine Sulfate 120 mg, Manufacturer-SAG) to a Single Oral Dose of Claritin-D® 12-Hour Extended Release Tablet (Loratadine 5 mg/Pseudoephedrine Sulfate 120 mg, Manufacturer-Heist) Under Fed Conditions in Healthy Adult Subjects Completed NCT03517943 Phase 1 Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-SAG);Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-Heist)
11 A Randomized, Crossover Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D® 12-Hour Extended Release Tablet (Loratadine 5mg/Pseudoephedrine Sulfate 120 mg, Manufacturer-SAG) to a Single Oral Dose of Claritin-D® 12-Hour Extended Release Tablet (Loratadine 5 mg/Pseudoephedrine Sulfate 120 mg, Manufacturer-Heist) Under Fasted Conditions in Healthy Adult Subjects Completed NCT03517930 Phase 1 Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-SAG);Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-Heist)
12 Evaluation of Immunological Changes and Clinical Efficacy of Specific Immunotherapy With Der p House Dust Mite Allergen in Polysensitized and Monosensitized Patients With Allergic Rhinitis and/or Asthma. Unknown status NCT01795846
13 Comparison Between Local and Imported Skin Prick Testing Result of Rat and Mouse Allergen Extracts in Respiratory Allergy Patients Completed NCT03645161
14 Probiotics for Reduction Of Markers In Subjects With Allergy Completed NCT01137357
15 Clinical Condition and Sleep Quality Factors Associated With Sleep Bruxism in Adults: a Study Using Polysomnography. Completed NCT04015349
16 Crustacean Allergy and Sensitization to Dust Mites in Patients With Respiratory Allergy: Clinical Study and Analysis of Common and Peculiar Allergens Completed NCT01634737
17 Quality of Life Assessment Before and After Hyposensitization Treatment in Systemic Nickel Allergy Syndrome Completed NCT03731494
18 The Effect of Beclomethasone Nasal Spray on Intraocular Pressure in Ocular Hypertension or Controlled Glaucoma Completed NCT00775489 Nasal steroid Beclomethasone;Saline
19 The Prevalence of Oral Allergy Syndrome and Types of Food Commonly Causing Reactions in Birch Pollen Sensitive Patients Who Have Springtime Hayfever Completed NCT00427479
20 Tromsø Birch Rust Allergy Study. Allergy to Birch Rust Fungi, a Possible Explanation to Seasonal Airway Allergy During Autumn? A Pilot Study With 30 Patients With Suspected Allergy to Birch Rust and 15 Non-allergic Controls. Not yet recruiting NCT04322838
21 Impact of Chronic Rhinosinusitis on the Laryngeal Mucosa and Voice Quality in Children Aged From 6- to 18- Years Old Not yet recruiting NCT03696693
22 ARomatherapy for Cognitive Trajectory in Chinese After Percutaneous Coronary Intervention (ARCTIC-PCI): a Randomized, Double-blind, Placebo-controlled Trial Not yet recruiting NCT04103086 Aromatherapy;Placebo
23 ARomatherapy for Cognitive Trajectory in Chinese After Coronary Artery Bypass Grafting (ARCTIC-CABG): a Randomized, Double-blind, Placebo-controlled Trial Not yet recruiting NCT04102696 Aromatherapy;Placebo

Search NIH Clinical Center for Respiratory Allergy

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Genetic Tests for Respiratory Allergy

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Anatomical Context for Respiratory Allergy

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The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory Allergy:

19
Respiratory Tract

MalaCards organs/tissues related to Respiratory Allergy:

40
Testes, Skin, Lung, T Cells, Lymph Node, Breast, B Cells
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Publications for Respiratory Allergy

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Articles related to Respiratory Allergy:

(show top 50) (show all 1711)
# Title Authors PMID Year
1
House Dust Mites: Does a Clean Mattress Mean Der p 1-free Breastmilk? 61
32521563 2020
2
Upper and Lower Airways Functional Examination in Asthma and Respiratory Allergic Deseases. Considerations in the SARS-CoV-2 Post-Pandemic Situation. 61
32540791 2020
3
A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark. 61
31342402 2020
4
Association between biomarkers and house dust mite sublingual immunotherapy in allergic asthma. 61
32557974 2020
5
RAPP-children: A new tool for assessing quality of life in patients with asthma and rhinitis. 61
32163631 2020
6
Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation. 61
32557721 2020
7
Occupational respiratory allergy to lettuce in lettuce farmers. 61
32542808 2020
8
Allergen immunotherapy for respiratory allergy: to what extent can the risk of systemic reactions be reduced? 61
32511028 2020
9
Influence of respiratory allergy and restless sleep on definite sleep bruxism: a cross-sectional clinical study. 61
32193053 2020
10
The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources. 61
32373267 2020
11
EAACI Allergen Immunotherapy User's Guide. 61
32436290 2020
12
Subcutaneous and sublingual allergen-specific immunotherapy: a tale of two routes. 61
32372588 2020
13
Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors of Long-term Asthma Severity. 61
31958440 2020
14
Allergen Immunotherapy for Local Respiratory Allergy. 61
32430550 2020
15
Prevalence of rat and mouse sensitization in Asian patients with respiratory allergy. 61
32416665 2020
16
30 years of sublingual immunotherapy. 61
31715001 2020
17
Gene expression changes in human bronchial epithelial cells (BEAS-2B) and human pulmonary alveolar epithelial cells (HPAEpiC) after interaction with Cladosporium sphaerospermum. 61
31309220 2020
18
Occurrence of pollen season at the end of the first trimester predicts clinical atopic diseases in the offspring: A Finnish population-based study. 61
32006881 2020
19
Molecular Diagnosis in House Dust Mite-Allergic Patients Suggests That Der p 23 Is Clinically Relevant in Asthmatic Children. 61
31283524 2020
20
Profilin is a marker of severity in allergic respiratory diseases. 61
31804710 2020
21
Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association. 61
32243436 2020
22
Evaluation of the effect of Toxocara cati infection in the mouse model of allergic asthma: Exacerbation of allergic asthma symptoms and Th2 types of response. 61
32408006 2020
23
Evaluating the Immunoreactivity of Ailanthus Altissima (The Tree of Heaven) Pollen Extract in Atopic Patients. 61
32372626 2020
24
Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. 61
32333915 2020
25
[Lung function in the German National Cohort: methods and initial results]. 61
32078705 2020
26
Subcutaneous immunotherapy with aeroallergens Evaluation of adherence in real life. 61
31789490 2020
27
Peptide Glycodendrimers as Potential Vaccines for Olive Pollen Allergy. 61
31990560 2020
28
NSG mice humanized with allergen-specific T-cell lines as in vivo model of respiratory allergy. 61
32145078 2020
29
Acaciain peptidase: The first South American pollen peptidase potentially involved in respiratory allergy. 61
31628771 2020
30
The contribution of particulate matter to respiratory allergy. 61
32105091 2020
31
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. 61
32187518 2020
32
Prevention of Allergic Asthma with Allergen Avoidance Measures and the Role of Exposome. 61
32103354 2020
33
Allergic reactions to genus Morus plants: a review. 61
32099533 2020
34
"New" inhalant plant allergens. 61
32357199 2020
35
Allergy in an Evolutionary Framework. 61
31175388 2020
36
Allergy Development in Adulthood: An Occupational Cohort Study of the Manufacturing of Industrial Enzymes. 61
31233941 2020
37
Identifying Potential Co-Sensitization and Cross-Reactivity Patterns Based on Component-Resolved Diagnosis. 61
31770759 2020
38
Asthmatic Airway Vagal Hypertonia Involves Chloride Dyshomeostasis of Preganglionic Neurons in Rats. 61
32082109 2020
39
Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000-2015: a retrospective multicentre study. 61
32003071 2020
40
Diphteria-tetanus-pertussis vaccine reduces specific IgE, inflammation and remodelling in an animal model of mite-induced respiratory allergy. 61
31630941 2020
41
Construction of multiple visual analog scale (UAD-9) for measuring severity of symptoms and quality of life of patients with respiratory allergy. 61
31269233 2020
42
Duration of allergen immunotherapy for inhalant allergy. 61
31464717 2019
43
Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease. 61
31195861 2019
44
Advances in allergen immunotherapy as a treatment of asthma. 61
31581868 2019
45
Diamine oxidase enzyme: a novel biomarker in respiratory allergy. 61
31532921 2019
46
Sensitization to grass allergens: Phl p1, Phl p5 and Phl p7 Phl p12 in adult and children patients in Beja (Southern Portugal). 61
31477404 2019
47
Therapeutic potential of peptides from Ole e 1 in olive-pollen allergy. 61
31685862 2019
48
High Frequency of Concomitant Food Allergy Development and Autoantibody Formation in Children Who Have Undergone Liver Transplantation. 61
30985574 2019
49
Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011. 61
31036486 2019
50
Food processing and occupational respiratory allergy- An EAACI position paper. 61
30953601 2019
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Variations for Respiratory Allergy

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Expression for Respiratory Allergy

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Search GEO for disease gene expression data for Respiratory Allergy.
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Pathways for Respiratory Allergy

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Pathways related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.93 RNASE3 NOS3 NOS1 IL5 IL4R IL4
2
ERK Signaling 63
Show member pathways
 13.83 IL5 IL4R IL4 IL3 IL2RB IL17A
3
TGF-Beta Pathway 63
Show member pathways
 13.55 IL5 IL4R IL4 IL3 IL2RB IL17A
4
PEDF Induced Signaling 63
Show member pathways
 13.54 TSLP NOS3 NOS1 IL5 IL4R IL4
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.4 IL5 IL4R IL4 IL33 IL3 IL2RB
6
Akt Signaling 63
Show member pathways
 13.36 NOS3 IL5 IL4R IL4 IL3 IL2RB
7
PAK Pathway 63
Show member pathways
 13.3 IL5 IL4R IL4 IL3 IL2RB IL17A
8
Pathways in cancer 36
12.86 IL5 IL4R IL4 IL3 IL2RB IL13
9
Allograft rejection 1 36
Show member pathways
 12.81 RNASE3 IL5 IL4 IL3 IL17A IL13
10
Immune response NFAT in immune response 22
Show member pathways
 12.61 IL4R IL4 IL10 ICOSLG CD4
11
Th17 cell differentiation 36
Show member pathways
 12.6 IL5 IL4R IL4 IL2RB IL17A IL13
12
T cell receptor signaling pathway 36
Show member pathways
 12.59 IL5 IL4 IL17A IL10 CD4
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.58 NOS3 NOS1 IL17A IL10 CD4
14
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.57 NOS3 IL5 IL4 IL3 IL13
15
NF-kappaB Signaling 4
12.55 IL4 IL3 IL2RB IL17A IL10
16
JAK-STAT signaling pathway 36
Show member pathways
 12.48 TSLP IL5 IL4R IL4 IL3 IL2RB
17
IL-17 Family Signaling Pathways 64
Show member pathways
 12.36 IL5 IL4 IL17A IL13 CCL11
18
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.3 IL2RB IL10 CCR6 CCL11
19
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.3 IL5 IL4 IL3 IL17A IL13 IL10
20
Jak Stat Signaling Pathway 66
Show member pathways
 12.08 IL4R IL4 IL2RB
21
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.08 IL5 IL4 IL3 IL2RB IL10 CD4
22
Interleukin-4 and 13 signaling 65
12.06 IL4R IL4 IL17A IL13 IL10 CCL11
23
Hematopoietic cell lineage 36
11.97 IL5 IL4R IL4 IL3 CD4
24
Th17 Differentiation 64
Show member pathways
 11.89 IL4R IL4 IL17A CD4
25
Glucocorticoid receptor regulatory network 1
11.77 IL5 IL4 IL13
26
IL4-mediated signaling events 1
11.76 IL5 IL4R IL4 IL10 CCL11
27
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.73 IL5 IL4 IL3
28
Lung fibrosis 1
11.71 IL5 IL4 IL13 CCL11
29
Arginine and proline metabolism 36
Show member pathways
 11.59 NOS3 NOS1 AOC1
30
Interleukin-10 signaling 65
11.52 IL4 IL13 IL10
31
Inflammatory Response Pathway 1
11.4 IL5 IL4R IL4 IL2RB
32
OX40 Pathway 63
11.28 IL5 IL4 IL13 IL10
33
Th2 Differentiation 64
11.27 IL5 IL4R IL4 IL33 IL2RB IL13
34
Development and heterogeneity of the ILC family 1
11.24 TSLP IL5 IL4 IL33 IL17A IL13
35
Innate Lymphoid Cells Differentiation 64
11.23 TSLP IL5 IL4 IL33 IL2RB IL17A
36
Cytokines and Inflammatory Response 1
11.1 IL5 IL4 IL3 IL13 IL10 CD4
37
G-protein signaling_Rap2B regulation pathway 22
11.05 IL5 IL4 IL3 IL17A IL13 IL10
38
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.89 IL5 IL4R IL4 IL13
39
NO-dependent CFTR activation (normal and CF) 22
10.8 NOS3 NOS1
40
Effects of Nitric Oxide 1
10.57 NOS3 NOS1
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GO Terms for Respiratory Allergy

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Cellular components related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TSLP RNASE3 IL5 IL4R IL4 IL33
2 external side of plasma membrane GO:0009897 9.63 IL2RB IL17A IL13 ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.4 TSLP RNASE3 IL5 IL4R IL4 IL33

Biological processes related to Respiratory Allergy according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.06 TSLP PDCL IL5 IL4R IL4 IL2RB
2 positive regulation of cell proliferation GO:0008284 10.05 TSLP IL5 IL4 IL3 GLI2
3 negative regulation of apoptotic process GO:0043066 10.04 TSLP IL4 IL2RB IL10 GLI2
4 positive regulation of transcription, DNA-templated GO:0045893 9.99 NOS1 IL5 IL4 IL10 GLI2 CD4
5 response to lipopolysaccharide GO:0032496 9.84 NOS3 NOS1 IL13 IL10
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 IL5 IL3 CD4
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TSLP IL4 IL3 IL13
8 T cell activation GO:0042110 9.7 IL4 ICOSLG CD4
9 positive regulation of B cell proliferation GO:0030890 9.65 IL5 IL4 IL13
10 immune response GO:0006955 9.65 IL5 IL4R IL4 IL3 IL17A IL13
11 macrophage activation GO:0042116 9.64 IL4 IL13
12 interleukin-15-mediated signaling pathway GO:0035723 9.64 IL2RB CD4
13 nitric oxide biosynthetic process GO:0006809 9.63 NOS3 NOS1
14 positive regulation of chemokine secretion GO:0090197 9.63 IL4R IL33
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL4 IL13 IL10
16 positive regulation of immunoglobulin secretion GO:0051024 9.62 IL5 IL33
17 positive regulation of interleukin-10 secretion GO:2001181 9.62 IL4 IL13
18 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.61 IL4 IL10
19 positive regulation of guanylate cyclase activity GO:0031284 9.61 NOS3 NOS1
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.6 IL4 IL10
21 negative regulation of potassium ion transport GO:0043267 9.59 NOS3 NOS1
22 negative regulation of hydrolase activity GO:0051346 9.58 NOS3 NOS1
23 positive regulation of interleukin-5 production GO:0032754 9.58 TSLP IL33
24 arginine catabolic process GO:0006527 9.57 NOS3 NOS1
25 positive regulation of immunoglobulin production GO:0002639 9.56 IL4R IL13
26 type 2 immune response GO:0042092 9.55 IL4 IL10
27 positive regulation of mast cell degranulation GO:0043306 9.54 IL4R IL4 IL13
28 regulation of isotype switching GO:0045191 9.49 IL4 IL10
29 positive regulation of macrophage activation GO:0043032 9.46 IL4R IL33 IL13 IL10
30 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
31 positive regulation of interleukin-13 production GO:0032736 9.43 TSLP IL4 IL33
32 cytokine-mediated signaling pathway GO:0019221 9.32 IL5 IL4R IL4 IL3 IL2RB IL17A

Molecular functions related to Respiratory Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL5 IL4 IL3 IL10
2 arginine binding GO:0034618 9.4 NOS3 NOS1
3 NADPH-hemoprotein reductase activity GO:0003958 9.37 NOS3 NOS1
4 cadmium ion binding GO:0046870 9.32 NOS3 NOS1
5 cytokine activity GO:0005125 9.28 TSLP IL5 IL4 IL33 IL3 IL17A
6 tetrahydrobiopterin binding GO:0034617 9.16 NOS3 NOS1
7 nitric-oxide synthase activity GO:0004517 8.96 NOS3 NOS1
Sources

Sources for Respiratory Allergy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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