Respiratory Distress Syndrome in Premature Infants (RDS)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Respiratory Distress Syndrome in Premature Infants

MalaCards integrated aliases for Respiratory Distress Syndrome in Premature Infants:

Name: Respiratory Distress Syndrome in Premature Infants 57 73 29
Hyaline Membrane Disease 58 73 71
Infant Acute Respiratory Distress Syndrome 58
Neonatal Respiratory Distress Syndrome 58
Respiratory Distress Syndrome, Newborn 71
Infant Respiratory Distress Syndrome 58
Hyaline Membrane Disease, Formerly 57
Rds of Prematurity 57
Rds in Prematurity 73
Infant Ards 58
Rds 73


Orphanet epidemiological data:

infant acute respiratory distress syndrome
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal;


57 (Updated 05-Mar-2021)
isolated cases

onset at birth
may be associated with polymorphisms in some surfactant genes, including sftpa1 , sftpb , and sftpc


respiratory distress syndrome in premature infants:
Inheritance multifactorial inheritance sporadic
Onset and clinical course congenital onset


Orphanet: 58  
Rare respiratory diseases

External Ids:

OMIM® 57 267450
MeSH 44 D006819
ICD10 via Orphanet 33 P22.0
UMLS via Orphanet 72 C0020192 C0035220 C0852283
Orphanet 58 ORPHA70587
MedGen 41 C1968593
UMLS 71 C0020192 C0035220

Summaries for Respiratory Distress Syndrome in Premature Infants

OMIM® : 57 The main cause of respiratory distress syndrome (RDS) in premature infants is a developmental deficiency of pulmonary surfactant. The frequency of RDS is inversely proportional to gestational age. However, not all infants born prematurely develop RDS, suggesting that there may be susceptibility factors. Because multiple factors can contribute to the pathogenesis of RDS specifically in premature infants, the etiology is considered to be multifactorial (summaries by Ramet et al., 2000; Clark and Clark, 2005). Pathogenic germline mutations in several genes involved in surfactant metabolism, including SFTPB (178640) and SFTPC (178620), can cause clinical features of respiratory distress syndrome in term neonates, children, and adults, disorders referred to as 'surfactant metabolism dysfunction' (see, e.g., SMDP1, 265120). Susceptibility to the development of RDS in premature infants may be associated with polymorphisms in surfactant genes, such as surfactant protein A1 (SFTPA1; 178630), SFTPB, and SFTPC (see MOLECULAR GENETICS). (267450) (Updated 05-Mar-2021)

MalaCards based summary : Respiratory Distress Syndrome in Premature Infants, also known as hyaline membrane disease, is related to respiratory distress syndrome, infant and pneumonia, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Respiratory Distress Syndrome in Premature Infants is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Metabolism of proteins and Diseases of metabolism. The drugs Beractant and Zinc have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and bone marrow, and related phenotypes are hypoxemia and atelectasis

UniProtKB/Swiss-Prot : 73 Respiratory distress syndrome in premature infants: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high- permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.

Wikipedia : 74 Infantile respiratory distress syndrome (IRDS), also called respiratory distress syndrome of newborn, or... more...

Related Diseases for Respiratory Distress Syndrome in Premature Infants

Diseases related to Respiratory Distress Syndrome in Premature Infants via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome, infant 31.8 SFTPC ABCA3
2 pneumonia 30.0 SFTPC SFTPB
3 meconium aspiration syndrome 29.7 SFTPB ABCA3
4 respiratory failure 29.6 SFTPC SFTPB ABCA3
5 adult respiratory distress syndrome 29.3 SFTPC SFTPB ABCA3
6 newborn respiratory distress syndrome 29.3 SFTPC SFTPB SFTPA1 ABCA3
7 interstitial emphysema 29.0 SFTPC SFTPB SFTPA1 ABCA3
8 neonatal respiratory failure 28.9 SFTPC SFTPB ABCA3
9 pulmonary hypertension 28.9 SFTPC SFTPB ABCA3
10 surfactant dysfunction 28.8 SFTPC SFTPB SFTPA1 ABCA3
11 pulmonary immaturity 28.7 SFTPC SFTPB SFTPA1 ABCA3
12 lung disease 28.6 SFTPC SFTPB SFTPA1 ABCA3
13 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 11.7
14 choroidal dystrophy, central areolar, 1 11.0
15 retinal degeneration 10.8
16 retinitis pigmentosa 10.7
17 neuroretinitis 10.7
18 retinitis 10.7
19 bronchopulmonary dysplasia 10.6
20 pneumothorax 10.5
21 retinal disease 10.5
22 patent ductus arteriosus 1 10.4
23 macular degeneration, age-related, 1 10.4
24 pattern dystrophy 10.4
25 pre-eclampsia 10.3
26 retinitis pigmentosa 7 10.3
27 fundus dystrophy 10.3
28 inherited retinal disorder 10.3
29 butterfly-shaped pigment dystrophy 10.3
30 macular dystrophy, patterned, 1 10.2
31 gestational diabetes 10.2
32 disseminated intravascular coagulation 10.2
33 pulmonary edema 10.2
34 choroidal dystrophy, central areolar 2 10.2
35 alcohol dependence 10.2
36 cone-rod dystrophy 2 10.2
37 macular dystrophy, vitelliform, 3 10.2
38 vitelliform macular dystrophy 10.2
39 enterocolitis 10.2
40 perinatal necrotizing enterocolitis 10.2
41 exudative vitreoretinopathy 1 10.1
42 cardiac arrest 10.1
43 rickets 10.1
44 periventricular leukomalacia 10.1
45 otitis media 10.1
46 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
47 preterm premature rupture of the membranes 10.1
48 funisitis 10.1
49 intrahepatic cholestasis of pregnancy 10.1
50 cerebral palsy 10.1

Graphical network of the top 20 diseases related to Respiratory Distress Syndrome in Premature Infants:

Diseases related to Respiratory Distress Syndrome in Premature Infants

Symptoms & Phenotypes for Respiratory Distress Syndrome in Premature Infants

Human phenotypes related to Respiratory Distress Syndrome in Premature Infants:

58 31 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypoxemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012418
2 atelectasis 58 31 frequent (33%) Frequent (79-30%) HP:0100750
3 premature birth 58 31 frequent (33%) Frequent (79-30%) HP:0001622
4 respiratory failure 58 31 frequent (33%) Frequent (79-30%) HP:0002878
5 tachypnea 58 31 frequent (33%) Frequent (79-30%) HP:0002789
6 cyanosis 58 31 frequent (33%) Frequent (79-30%) HP:0000961
7 pulmonary edema 58 31 frequent (33%) Frequent (79-30%) HP:0100598
8 nasal flaring 58 31 frequent (33%) Frequent (79-30%) HP:0030863
9 abnormal thorax morphology 31 frequent (33%) HP:0000765
10 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
11 tachycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001649
12 pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002090
13 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
14 bradycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001662
15 sepsis 58 31 very rare (1%) Very rare (<4-1%) HP:0100806
16 neonatal respiratory distress 31 HP:0002643
17 abnormality of the thorax 58 Frequent (79-30%)
18 respiratory distress 31 HP:0002098
19 respiratory tract infection 58 Occasional (29-5%)
20 disseminated intravascular coagulation 31 HP:0005521

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
respiratory insufficiency, neonatal

Prenatal Manifestations Delivery:
premature delivery, less than 37 weeks' gestation

Respiratory Lung:
decreased surfactant
lung edema
fibrin-rich alveolar deposits, 'hyaline membranes'
diffuse reticulogranular pattern seen on chest radiograph

Clinical features from OMIM®:

267450 (Updated 05-Mar-2021)

UMLS symptoms related to Respiratory Distress Syndrome in Premature Infants:

dyspnea, hemoptysis, apnea, respiratory distress, cheyne-stokes respiration, coughing, hoarseness

MGI Mouse Phenotypes related to Respiratory Distress Syndrome in Premature Infants:

# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 ABCA3 SFTPA1 SFTPB SFTPC

Drugs & Therapeutics for Respiratory Distress Syndrome in Premature Infants

Drugs for Respiratory Distress Syndrome in Premature Infants (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 325)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Beractant Approved Phase 4 108778-82-1
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Racepinephrine Approved Phase 4 329-65-7 838
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Cisatracurium Approved Phase 4 96946-41-7 62887
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Ibuprofen Approved Phase 4 15687-27-1 3672
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
18 Poractant alfa Approved Phase 4 129069-19-8
Remifentanil Approved Phase 4 132875-61-7 60815
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Budesonide Approved Phase 4 51333-22-3 63006 5281004
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
26 Neurotransmitter Agents Phase 4
27 Carotenoids Phase 4
Picolinic acid Phase 4 98-98-6 1018
29 Provitamins Phase 4
30 Chelating Agents Phase 4
31 Iron Chelating Agents Phase 4
32 Adrenergic alpha-Agonists Phase 4
33 Hydrocortisone 17-butyrate 21-propionate Phase 4
34 Hydrocortisone hemisuccinate Phase 4
35 Epinephryl borate Phase 4
36 Cholinergic Antagonists Phase 4
37 Cholinergic Agents Phase 4
38 Neuromuscular Blocking Agents Phase 4
39 Psychotropic Drugs Phase 4
40 GABA Modulators Phase 4
41 Anti-Anxiety Agents Phase 4
42 Neuromuscular Nondepolarizing Agents Phase 4
43 Anesthetics Phase 4
44 Excitatory Amino Acid Antagonists Phase 4
45 Anesthetics, Intravenous Phase 4
46 Anesthetics, Dissociative Phase 4
47 Anesthetics, General Phase 4
48 Analgesics, Opioid Phase 4
49 Hypnotics and Sedatives Phase 4
50 Angiotensin Receptor Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 917)
# Name Status NCT ID Phase Drugs
1 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
2 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Unknown status NCT02164734 Phase 4 remifentanil
3 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Unknown status NCT03366584 Phase 4 Dexamethasone
4 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
5 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
6 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Sleep Intervention During Acute Lung Injury Unknown status NCT01050699 Phase 4 Dexmedetomidine;Midazolam and Fentanyl
8 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
10 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
11 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
12 Routine Administration of Surfactant/Budesonide to Prevent BPD in VLBW With RDS-A Double Blind Study Unknown status NCT03275415 Phase 4 budesonide;Saline
13 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
14 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Unknown status NCT02978976 Phase 4 Betamethasone;saline
15 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Completed NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
16 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
17 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
18 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
19 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
20 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
21 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
22 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
23 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
24 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
25 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
26 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
27 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
28 PRAETORIAN-COVID: A Double-blind, Placebo-controlled Randomized Clinical Trial With Valsartan for PRevention of Acute rEspiraTORy dIstress Syndrome in hospitAlized patieNts With SARS-COV-2 (COVID-19) Infection Disease Recruiting NCT04335786 Phase 4 Valsartan (Diovan);Placebo oral tablet
29 Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection Recruiting NCT04359862 Phase 4 Sevoflurane;Propofol
30 Lipid Ibuprofen Versus Standard of Care for Acute Hypoxemic Respiratory Failure Due to COVID-19: a Multicentre, Randomised, Controlled Trial Recruiting NCT04334629 Phase 4 Ibuprofen
31 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
32 Premedication for Less Invasive Surfactant Administration Recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
33 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
34 Exogenous Surfactant in Very Preterm Neonates Presenting With Severe Respiratory Distress in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
35 Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy. Not yet recruiting NCT04073173 Phase 4 Analgesic, Opioid
36 The Effect of Spironolactone on Oxygenation in Covid-19 ARDS Patients Not yet recruiting NCT04345887 Phase 4 Spironolactone 100mg;Placebo oral tablet
37 Comparison of Two Fraction Oxygen Inspired (FiO2) Thresholds for the Surfactant Administration in Preterm Infants With Respiratory Disease Syndrome: a Single-center Randomized Phase IV Clinical Trial Not yet recruiting NCT04199364 Phase 4 Poractant Alfa 80 mg/mL Intratracheal Suspension
38 Effects of Adding L-Carnitine With Dexamethasone on Respiratory Distress Syndrome Development in Preterm Infants Suspended NCT03630367 Phase 4 Dexamethasone;L-Carnitine 1G/5mL Injection
39 Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Terminated NCT04325061 Phase 4 Dexamethasone
40 Phase 4 Study of Curosurf (Poractant) and Survanta (Beractant) Surfactant Treatment in Very Premature Infants With Respiratory Distress Syndrome. Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
41 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
42 Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants Terminated NCT00146497 Phase 4 Budesonide-Surfactant
43 Randomized Study Comparing the ASV to Conventional Ventilation for Intubated Patients During Inter-hospital Transfers. Controlled Randomized Monocentric Prospective Study Comparing ASV Versus Conventional Ventilation Modes Terminated NCT02348047 Phase 4
44 Pre Hospital Evaluation of Video Laryngoscopy : a Comparative Study of Macintosh and GLIDESCOPE Ranger® Withdrawn NCT01374061 Phase 4
45 Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome Unknown status NCT01265589 Phase 3 surfactant;surfactant+vitamin A
46 Liberal Oxygenation Versus Conservative Oxygenation in Patients With Acute Respiratory Distress Syndrome : Impact on Mortality (LOCO2 Study) Unknown status NCT02713451 Phase 3 Modulation of Inspired Fraction of Oxygen (FiO2)
47 Evaluating the Efficacy and Safety of an Innovative and Affordable Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates: a Multi-site Randomized Clinical Trial Unknown status NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
48 A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients Unknown status NCT00465374 Phase 3
49 Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room. Unknown status NCT01517828 Phase 3 Sedation by ketamine;Sedation with Midazolam
50 Efficacy and Safety of NIPPV to Increase Survival Without Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants Completed NCT00433212 Phase 3

Search NIH Clinical Center for Respiratory Distress Syndrome in Premature Infants

Inferred drug relations via UMLS 71 / NDF-RT 51 :

Albumin Human, USP
colfosceril palmitate
Nitric Oxide
Poractant alfa

Genetic Tests for Respiratory Distress Syndrome in Premature Infants

Genetic tests related to Respiratory Distress Syndrome in Premature Infants:

# Genetic test Affiliating Genes
1 Respiratory Distress Syndrome in Premature Infants 29

Anatomical Context for Respiratory Distress Syndrome in Premature Infants

MalaCards organs/tissues related to Respiratory Distress Syndrome in Premature Infants:

Lung, Fetal Lung, Bone Marrow, Bone, Neutrophil, Heart, Liver

Publications for Respiratory Distress Syndrome in Premature Infants

Articles related to Respiratory Distress Syndrome in Premature Infants:

(show top 50) (show all 1726)
# Title Authors PMID Year
The genetics of neonatal respiratory disease. 57
15927881 2005
Surfactant protein C gene variation in the Finnish population - association with perinatal respiratory disease. 57
14735158 2004
Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. 57
12483294 2003
Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. 57
11063734 2000
Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population. 57
10762543 2000
Surfactant protein A and saturated phosphatidylcholine in respiratory distress syndrome. 57
7952631 1994
Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid. Correlation with surface activity, severity of respiratory distress syndrome, and outcome in small premature infants. 57
1741552 1991
Respiratory-distress syndrome and disseminated intravascular coagulation in two siblings. 57
4108940 1972
Surfactant dysfunction disorder masquerading as meconium aspiration syndrome and persistent pulmonary hypertension of the newborn. 61
33504532 2021
Optimal delivery timing for twin pregnancies: A population-based retrospective cohort study. 61
33420725 2021
Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury. 61
33230985 2020
A survey on criteria for intubation in moderate to late preterm infants with respiratory distress. 61
32886426 2020
Bovine or Porcine: Does the Type of Surfactant Matter? 61
32112649 2020
Novel homozygous missense mutation in ABCA3 protein leading to severe respiratory distress in term infant. 61
33040033 2020
Extrauterine growth restriction in very preterm infant: etiology, diagnosis, and 2-year follow-up. 61
32193657 2020
Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. 61
32275979 2020
Neuroendoscopic lavage for the management of posthemorrhagic hydrocephalus in preterm infants: safety, effectivity, and lessons learned. 61
32413865 2020
Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre. 61
33402932 2020
50 Years Ago in TheJournalofPediatrics: Intermittent Positive Pressure Ventilation in Hyaline Membrane Disease. 61
32040408 2020
50 Years Ago in TheJournalofPediatrics: Commentary: The Use of Assisted Ventilation in the Therapy of Hyaline Membrane Disease. 61
32040409 2020
Effects of less invasive surfactant administration (LISA) via a gastric tube on the treatment of respiratory distress syndrome in premature infants aged 32 to 36 weeks. 61
32118723 2020
Etiology, clinical profile and outcome of neonatal pneumothorax in tertiary care center in South India: 13 years experience. 61
32075452 2020
Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt. 61
32140431 2020
Minimally Invasive Tissue Sampling in Preterm Deaths: A Validation Study. 61
32923527 2020
The influence of maternal ethnicity on neonatal respiratory outcome. 61
31123055 2020
Comparison of the detection rates for retinopathy of prematurity (ROP) of the 2013 Philippine Academy of Ophthalmology (PAO) Revised Philippine Guidelines and the 2005 PAO-Philippine Pediatric Society (PPS) Guidelines for ROP screening in the Philippine General Hospital: a 5-year review. 61
33094166 2020
Tension pneumocephalus, an uncommon complication of oxygen therapy in preterm newborns. Presentation of a case and literature review. 61
31784352 2019
Fetal, neonatal, and infant death in central China (Hubei): A 16-year retrospective study of forensic autopsy cases. 61
31169678 2019
Outcome of Respiratory Distress in Neonates with Bubble CPAP at Neonatal Intensive Care Unit of a Tertiary Hospital. 61
31477940 2019
Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. 61
30819143 2019
Growth restriction increases the risk of bronchopulmonary dysplasia, death, and sepsis in twins of 30 weeks or less of gestation. 61
31095217 2019
Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30616641 2019
Case report of a laryngotracheal reconstruction with anterior and posterior costal cartilage graft and stent placement - Surgical technique. 61
31039513 2019
Co-initiation of continuous renal replacement therapy, peritoneal dialysis, and extracorporeal membrane oxygenation in neonatal life-threatening hyaline membrane disease: A case report. 61
30681590 2019
Phospholipid components of the synthetic pulmonary surfactant CHF5633 probed by fluorescence spectroscopy. 61
30366070 2018
Hyaline membrane disease (HMD): an historical and Oslerian perspective. 61
30291319 2018
Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30522518 2018
An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. 61
30303136 2018
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. 61
30289565 2018
Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa. 61
30645966 2018
A pre-term infant of 32 weeks gestation with congenital tuberculosis treated successfully with antituberculosis chemotherapy. 61
28805143 2018
Scenario of Neonatal Respiratory Distress in Tertiary Hospital. 61
29983424 2018
A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period. 61
30004050 2018
Clinicoetiological Pattern and Outcome of Neonates Requiring Mechanical Ventilation: Study in a Tertiary Care Centre. 61
29910548 2018
Neonatal respiratory distress syndrome and underlying mechanisms in cloned cattle. 61
29388718 2018
Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects. 61
29559762 2018
Kidneys in 5-year-old preterm-born children: a longitudinal cohort monitoring of renal function. 61
28665930 2017
[Congenital cytomegalovirus infection manifesting as neonatal respiratory distress in an HIV-exposed uninfected newborn]. 61
28734808 2017
Maternal and neonatal outcomes in twin and triplet gestations in Western Saudi Arabia. 61
28578447 2017
Postoperative complications following neonatal and infant surgery: Common events and predictive factors. 61
27671979 2017

Variations for Respiratory Distress Syndrome in Premature Infants

Expression for Respiratory Distress Syndrome in Premature Infants

Search GEO for disease gene expression data for Respiratory Distress Syndrome in Premature Infants.

Pathways for Respiratory Distress Syndrome in Premature Infants

Pathways related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
3 11.06 SFTPC SFTPA1
Show member pathways
Show member pathways

GO Terms for Respiratory Distress Syndrome in Premature Infants

Cellular components related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.67 SFTPC SFTPB SFTPA1 ABCA3
2 endoplasmic reticulum membrane GO:0005789 9.58 SFTPC SFTPB SFTPA1
3 clathrin-coated endocytic vesicle GO:0045334 9.33 SFTPC SFTPB SFTPA1
4 multivesicular body GO:0005771 9.32 SFTPB SFTPA1
5 multivesicular body lumen GO:0097486 9.26 SFTPC SFTPB
6 lamellar body GO:0042599 9.13 SFTPC SFTPB SFTPA1
7 alveolar lamellar body GO:0097208 8.8 SFTPC SFTPB ABCA3

Biological processes related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.16 SFTPA1 ABCA3
2 respiratory gaseous exchange GO:0007585 9.13 SFTPC SFTPB SFTPA1
3 cellular protein metabolic process GO:0044267 8.92 SFTPC SFTPB SFTPA1 ABCA3

Molecular functions related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 8.62 SFTPA1 ABCA3

Sources for Respiratory Distress Syndrome in Premature Infants

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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