Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: RSP003
MIFTS: 70

Respiratory Failure

Categories: Respiratory diseases, Fetal diseases, Rare diseases, Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Respiratory Failure

About this section

MalaCards integrated aliases for Respiratory Failure:

Name: Respiratory Failure 12 29 55 43 15 63 73
Chronic Respiratory Failure 12 55 73
Acute Respiratory Failure 12 55 73
Respiratory Insufficiency 29 6 73
Acute-on-Chronic Respiratory Failure 12 73
Acute and Chronic Respiratory Failure 12
Chronic Disease of Respiratory System 73
Respiratory Insufficiency/failure 12
Pulmonary Valve Insufficiency 73
Chronic Respiratory Disease 55
Respiratory Tract Diseases 73
Respiration Disorders 73
Respiratory Disease 55

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases Infectious diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Respiratory Failure

About this section
MedlinePlus : 43 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well. Respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs. Diseases and conditions that affect your breathing can cause respiratory failure. Examples include Lung diseases such as COPD (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis Conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage. Drug or alcohol overdose Injuries from inhaling smoke or harmful fumes Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. It also depends on the underlying cause. You may receive oxygen therapy and other treatment to help you breathe. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Respiratory Failure, also known as chronic respiratory failure, is related to neonatal respiratory failure and adult respiratory distress syndrome, and has symptoms including anoxemia, apnea and pleuritic pain. An important gene associated with Respiratory Failure is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Diseases of metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Riluzole and Beractant have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related phenotypes are homeostasis/metabolism and behavior/neurological

CDC : 3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and “gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Disease Ontology : 12 A lung disease characterized by inadequate gas exchange by the respiratory system.

PubMed Health : 63 About respiratory failure: Respiratory (RES-pih-rah-tor-e) failure is a condition in which not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well.Respiratory failure also can occur if your lungs can't properly remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs.Both of these problems—a low oxygen level and a high carbon dioxide level in the blood—can occur at the same time.Diseases and conditions that affect your breathing can cause respiratory failure. Examples include COPD (chronic obstructive pulmonary disease) and spinal cord injuries. COPD prevents enough air from flowing in and out of the airways. Spinal cord injuries can damage the nerves that control breathing.

Wikipedia : 76 Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the... more...

Sources

Related Diseases for Respiratory Failure

About this section

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 496)
# Related Disease Score Top Affiliating Genes
1 neonatal respiratory failure 34.9 SFTPB SFTPC
2 adult respiratory distress syndrome 32.3 ELANE SFTPB SFTPC TNF
3 rigid spine muscular dystrophy 1 32.0 GAA LAMA2 TTN
4 newborn respiratory distress syndrome 31.8 NKX2-1 SFTPB SFTPC TTN
5 pulmonary fibrosis, idiopathic 30.9 ELANE SCGB1A1 SFTPB SFTPC SFTPD TNF
6 lung disease 30.8 ELANE PDE4A SFTPB SFTPC SFTPD TNF
7 bronchopulmonary dysplasia 30.7 ELANE SCGB1A1 SFTPB
8 neuromuscular disease 30.5 DCTN1 GAA LAMA2 TTN
9 burns 30.2 ALB TNF TTR
10 farmer's lung 30.2 ELANE TNF
11 diaphragmatic hernia, congenital 30.2 NKX2-1 SFTPB SFTPC
12 meconium aspiration syndrome 30.2 SCGB1A1 SFTPB TNF
13 bronchitis 30.2 ALB ELANE TNF
14 pulmonary alveolar proteinosis 30.2 SFTPB SFTPC SFTPD
15 idiopathic interstitial pneumonia 29.7 ELANE SFTPC SFTPD
16 lung cancer susceptibility 3 29.6 NKX2-1 SCGB1A1 SFTPB SFTPC
17 pneumocystosis 29.5 ALB SFTPD TNF
18 interstitial lung disease 29.4 NKX2-1 SFTPB SFTPC SFTPD TNF
19 pulmonary disease, chronic obstructive 29.4 ELANE PDE4A SCGB1A1 SFTPB SFTPD TNF
20 acute respiratory distress syndrome 29.1 ELANE SFTPB SFTPC SFTPD TNF
21 pneumonia 28.8 ELANE PIK3C2A SCGB1A1 SFTPB SFTPC SFTPD
22 hereditary myopathy with early respiratory failure 12.5
23 hereditary proximal myopathy with early respiratory failure 12.2
24 myopathy, distal, with early respiratory failure, autosomal dominant 12.0
25 spinal muscular atrophy, distal, autosomal recessive, 1 11.9
26 muscular dystrophy, congenital, davignon-chauveau type 11.4
27 combined oxidative phosphorylation deficiency 3 11.1
28 amyotrophic lateral sclerosis 1 11.1
29 acute interstitial pneumonia 11.1
30 alveolar capillary dysplasia 11.1
31 idiopathic acute eosinophilic pneumonia 11.1
32 status asthmaticus 11.0
33 pulmonary edema 11.0
34 thyrotoxic periodic paralysis 11.0
35 asthma, nasal polyps, and aspirin intolerance 11.0
36 bronchiectasis 11.0
37 central hypoventilation syndrome, congenital 11.0
38 spinal muscular atrophy with respiratory distress type 2 11.0
39 distal hereditary motor neuropathies 11.0 DCTN1 IGHMBP2
40 paramyloidosis 11.0 ALB TTR
41 perry syndrome 11.0
42 leigh syndrome 11.0
43 guillain-barre syndrome 11.0
44 trichinosis 11.0
45 respiratory distress syndrome in premature infants 10.9 SFTPB SFTPC
46 paraquat lung 10.9 SCGB1A1 SFTPB
47 ligneous conjunctivitis 10.9 ELANE TTR
48 opsismodysplasia 10.9
49 nemaline myopathy 8 10.9
50 de quervain disease 10.8 ELANE SLC4A1

Comorbidity relations with Respiratory Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 120)


Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alcohol Abuse
Alcoholic Cardiomyopathy Alcoholic Liver Cirrhosis
Anthracosis Anxiety
Aortic Aneurysm Aortic Valve Disease 1
Asbestosis Aspergillosis
Asthma Bleeding Disorder, Platelet-Type, 11
Bronchiectasis Bronchitis
Bronchopneumonia Candidiasis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Conjunctivitis
Conn's Syndrome Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Diaphragm Disease
Disseminated Intravascular Coagulation Dysthymic Disorder
Encephalopathy Esophageal Candidiasis
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Goodpasture Syndrome
Guillain-Barre Syndrome, Familial Heart Disease
Hepatic Encephalopathy Hypertension, Essential
Hypertensive Encephalopathy Hypertrophic Cardiomyopathy

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to Respiratory Failure
Sources

Symptoms & Phenotypes for Respiratory Failure

About this section

UMLS symptoms related to Respiratory Failure:


anoxemia, apnea, pleuritic pain, cheyne-stokes respiration, coughing, cyanosis, dyspnea, edema, hemoptysis, hoarseness, stridor, wheezing, sinus congestion, other symptoms involving respiratory system and chest, signs and symptoms of ill-defined conditions, inspiratory wheeze, expiratory wheeze, bronchorrhea, neonatal cyanosis, gasping for breath, symptoms involving respiratory system and other chest symptoms, respiratory distress, choking sensation, labored breathing, inspiratory stridor, sneezing, nasal congestion (finding), pathological conditions, signs and symptoms, nasal irritation, sore throat, neck tightness, larynx pain, rhinorrhea, snoring

MGI Mouse Phenotypes related to Respiratory Failure:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ALB ALPL CHAT DCTN1 ELANE GAA
2 behavior/neurological MP:0005386 10.31 ALPL CHAT DCTN1 GAA IGHMBP2 LAMA2
3 growth/size/body region MP:0005378 10.28 SFTPD SLC4A1 TK2 TNF TTN ALPL
4 cardiovascular system MP:0005385 10.26 IGHMBP2 NKX2-1 PDE4A PIK3C2A SFTPC SLC4A1
5 mortality/aging MP:0010768 10.25 CHAT DCTN1 ELANE IGHMBP2 LAMA2 NKX2-1
6 cellular MP:0005384 10.23 ALB ALPL DCTN1 GAA IGHMBP2 LAMA2
7 immune system MP:0005387 10.15 ELANE LAMA2 PDE4A PIK3C2A SCGB1A1 SFTPC
8 muscle MP:0005369 9.96 ALB ALPL CHAT GAA IGHMBP2 LAMA2
9 nervous system MP:0003631 9.65 ALPL CHAT DCTN1 IGHMBP2 LAMA2 NKX2-1
10 neoplasm MP:0002006 9.63 ALB ELANE NKX2-1 SCGB1A1 SFTPC TNF
11 respiratory system MP:0005388 9.28 ALPL CHAT IGHMBP2 NKX2-1 SCGB1A1 SFTPB
Sources

Drugs & Therapeutics for Respiratory Failure

About this section

PubMedHealth treatment related to Respiratory Failure: 63

Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and its severity. Treatment also depends on the condition's underlying cause.Acute respiratory failure can be a medical emergency. It often is treated in an intensive care unit at a hospital. Chronic respiratory failure often can be treated at home. If chronic respiratory failure is severe, your doctor may recommend treatment in a long-term care center.One of the main goals of treating respiratory failure is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the underlying cause of the condition.

Drugs for Respiratory Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 570)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Riluzole Approved, Investigational Phase 4,Phase 2,Phase 3 1744-22-5 5070
2 Beractant Approved Phase 4,Phase 3 108778-82-1
3 Poractant alfa Approved Phase 4,Phase 2,Not Applicable 129069-19-8
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 23994
5
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
6
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
7
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
8
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
9
Clonidine Approved Phase 4 4205-90-7 2803
10 Nefopam Approved, Investigational Phase 4 13669-70-0
11
Ropivacaine Approved Phase 4,Phase 3,Not Applicable 84057-95-4 71273 175805
12
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
13
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
16
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
17
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
18
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
19
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068 160954
20
Menthol Approved Phase 4,Phase 3,Phase 1,Not Applicable 2216-51-5 16666
21
Ketamine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 6740-88-1 3821
22
Nitrous oxide Approved, Vet_approved Phase 4,Phase 2,Phase 3 10024-97-2 948
23
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754
25
Diclofenac Approved, Vet_approved Phase 4,Not Applicable 15307-86-5 3033
26
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
27
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
28
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
29
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
30
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Not Applicable 616-91-1 12035
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
32
Furosemide Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54-31-9 3440
33
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
34
Adenosine Approved, Investigational Phase 4 58-61-7 60961
35
Remifentanil Approved Phase 4,Phase 1,Not Applicable 132875-61-7 60815
36
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
37
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
38
Clopidogrel Approved Phase 4,Not Applicable 120202-66-6, 113665-84-2 60606
39
Ticlopidine Approved Phase 4,Not Applicable 55142-85-3 5472
40
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
41
Metoprolol Approved, Investigational Phase 4,Phase 3 37350-58-6, 51384-51-1 4171
42
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
43
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
44
Ipratropium Approved Phase 4,Not Applicable 22254-24-6, 60205-81-4 43232
45
Citalopram Approved Phase 4 59729-33-8 2771
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 437-38-7 3345
47
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
48
Orphenadrine Approved Phase 4 83-98-7 4601
49
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
50
Insulin Aspart Approved Phase 4,Not Applicable 116094-23-6 16132418

Interventional clinical trials:

(show top 50) (show all 1609)
# Name Status NCT ID Phase Drugs
1 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
2 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
3 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
4 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
5 Inspiratory Muscle Training in Hypercapnic COPD Unknown status NCT00291460 Phase 4
6 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Unknown status NCT01513655 Phase 4
7 Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Unknown status NCT00560287 Phase 4
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
9 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
10 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
11 A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
12 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
13 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
14 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
15 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
16 Influence of Moderate Inspired Oxygen Fraction (FiO2) and Protective Ventilation on Postoperative Pulmonary Complication Unknown status NCT02198625 Phase 4
17 Steroids In caRdiac Surgery Trial (SIRS Trial) Unknown status NCT00427388 Phase 4 Methylprednisolone
18 Acupuncture for Sedation in the Intensive Care Unit (ICU) Unknown status NCT01362270 Phase 4
19 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
20 Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
21 Helmet Ventilation in Acute Hypercapnic Respiratory Failure Completed NCT01645358 Phase 4
22 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
23 Ambulatory Adaptation to Non-Invasive Mechanical Ventilation Completed NCT00698958 Phase 4
24 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
25 Non-invasive Ventilation in Terminally Ill Cancer Patients Completed NCT00533143 Phase 4
26 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4
27 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
28 Inhaled Nitric Oxide by Oxygen Hood in Neonates Completed NCT00732537 Phase 4 inhaled Nitric Oxide;Oxygen (>90% by hood) - standard therapy
29 Early Application of CPAP in Hematologic Completed NCT00507533 Phase 4
30 Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
31 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
32 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
33 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
34 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients Completed NCT00355732 Phase 4
35 Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients Completed NCT01472302 Phase 4
36 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
37 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
38 Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics Completed NCT02363920 Phase 4
39 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
40 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
41 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo
42 Anesthesia for Retinopathy of Prematurity Completed NCT01955135 Phase 4 Ketamine;Sevoflurane;propofol
43 Supplemental Oxygen and Complications After Abdominal Surgery (The PROXI-trial) Completed NCT00364741 Phase 4 Oxygen
44 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4
45 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
46 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
47 Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome Completed NCT02041546 Phase 4 Lung lavage with surfactant;Bolus surfactant
48 Azithromycin in the Prevention of Lung Injury in Premature Newborn Completed NCT03485703 Phase 4 Azithromycin;Placebo
49 Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter Completed NCT01914926 Phase 4 Metoprolol;Diltiazem
50 Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely Completed NCT00390065 Phase 4 Nitric Oxide

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Respiratory Failure

About this section

Genetic tests related to Respiratory Failure:

# Genetic test Affiliating Genes
1 Respiratory Failure 29
2 Respiratory Insufficiency 29
Sources

Anatomical Context for Respiratory Failure

About this section

MalaCards organs/tissues related to Respiratory Failure:

41
Lung, Heart, Brain, Testes, Spinal Cord, Liver, Kidney
Sources

Publications for Respiratory Failure

About this section

Articles related to Respiratory Failure:

(show top 50) (show all 1279)
# Title Authors Year
1
Outcomes and Mortality Prediction Model of Critically Ill Adults With Acute Respiratory Failure and Interstitial Lung Disease. ( 29353024 )
2018
2
ABCA3 Deficiency in a Newborn with Respiratory Failure. ( 29970269 )
2018
3
Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation. ( 29973963 )
2018
4
A Prospective Study of Bacteriological Etiology in Hospitalized Acute Exacerbation of COPD Patients: Relationship with Lung Function and Respiratory Failure. ( 29404182 )
2018
5
German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation: Revised Edition 2017 - Part 1. ( 29945148 )
2018
6
Progressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure. ( 29406380 )
2018
7
When Antimicrobial Therapy Is Not Enough: Respiratory Failure in a Patient with Chronic Granulomatous Disease. ( 29714104 )
2018
8
Does Extracorporeal Membrane Oxygenation Improve Survival in Pediatric Acute Respiratory Failure? ( 29373797 )
2018
9
Pediatric Specialty Care Model for Management of Chronic Respiratory Failure: Cost and Savings Implications and Misalignment With Payment Models. ( 29406371 )
2018
10
Pre-stroke undiagnosed dysphagia lusoria as a rare cause of aspiration pneumonia with respiratory failure in a stroke patient. ( 29552342 )
2018
11
High flow nasal cannulae oxygen therapy in acute-moderate hypercapnic respiratory failure. ( 29392846 )
2018
12
Management of adult-onset methylmalonic acidemia with hypotonia and acute respiratory failure: A case report. ( 29924026 )
2018
13
Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients: reply. ( 29943165 )
2018
14
Rare Cause of Respiratory Failure: A Twist in the Tale. ( 29957035 )
2018
15
Respiratory failure in a diabetic ketoacidosis patient with severe hypophosphatemia. ( 29969883 )
2018
16
Inhaled nitric oxide mitigates need for extracorporeal membrane oxygenation in a patient with refractory acute hypoxemic respiratory failure due to cardiac and pulmonary shunts. ( 29977772 )
2018
17
Noninvasive Ventilation for Acute Respiratory Failure due to Noncystic Fibrosis Bronchiectasis. ( 29910541 )
2018
18
Veno-venous extracorporeal membrane oxygenation bridged living-donor lung transplantation for rapid progressive respiratory failure with pleuroparenchymal fibroelastosis after allogeneic hematopoietic stem cell transplantation. ( 29773298 )
2018
19
Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis. ( 29379704 )
2018
20
Noninvasive ventilation for respiratory failure: a note of caution in selected patients. ( 29934923 )
2018
21
What is the Impact of Mildly Altered Consciousness on Acute Hypoxemic Respiratory Failure with Non-invasive ventilation? ( 29434147 )
2018
22
German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation - Revised Edition 2017: Part 2. ( 29945156 )
2018
23
Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. ( 29360422 )
2018
24
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
25
What Can We Apply to Manage Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Respiratory Failure? ( 29372630 )
2018
26
Prognostic factors of noninvasive mechanical ventilation in lung cancer patients with acute respiratory failure. ( 29329356 )
2018
27
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
28
Loss of <i>Atoh1</i> from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. ( 29972353 )
2018
29
Frailty Characteristics Predict Respiratory Failure in Patients Undergoing Tracheobronchoplasty. ( 29959941 )
2018
30
Methotrexate-associated lymphoproliferative disorder complicated by severe acute respiratory failure and ileal perforation: a case report. ( 29925726 )
2018
31
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
32
Effectiveness and Safety of High-Flow Nasal Cannula Oxygen Delivery during Bronchoalveolar Lavage in Acute Respiratory Failure Patients. ( 29926546 )
2018
33
Hypophosphatemia and duration of respiratory failure and mortality in critically ill patients. ( 29687440 )
2018
34
<i>Neisseria meningitidis</i> sepsis in a patient with acute epiglottitis and respiratory failure. ( 29804070 )
2018
35
Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan. ( 29936329 )
2018
36
Is endotracheal intubation a non-beneficial treatment in patients with respiratory failure due to paraquat poisoning? ( 29590187 )
2018
37
Extracorporeal Membrane Oxygenation for Refractory Severe Respiratory Failure in Acute Interstitial Pneumonia. ( 29323413 )
2018
38
Acute Respiratory Failure in Pediatric Hematopoietic Cell Transplantation-A Multicenter Study. ( 29965835 )
2018
39
Double aortic arch presenting as neonatal respiratory failure in the delivery room. ( 29248031 )
2018
40
The ACUTE (Ambulance CPAP: Use, Treatment effect and economics) feasibility study: a pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. ( 29946477 )
2018
41
Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. ( 29415760 )
2018
42
Positive end expiratory pressure in acute hypoxemic respiratory failure due to community acquired pneumonia: do we need a personalized approach? ( 29404202 )
2018
43
Admission volume is associated with mortality of neonatal respiratory failure in emerging neonatal intensive care units. ( 29385861 )
2018
44
Efficacy and Tolerability of High-Flow Nasal Cannula Oxygen Therapy for Hypoxemic Respiratory Failure in Patients with Interstitial Lung Disease with Do-Not-Intubate Orders: A Retrospective Single-Center Study. ( 29954000 )
2018
45
Dyspnea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact - a prospective observational study. ( 29976650 )
2018
46
Role of Domiciliary Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease Patients Requiring Repeated Admissions with Acute Type II Respiratory Failure: A Prospective Cohort Study. ( 29962738 )
2018
47
Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells. ( 28873200 )
2017
48
Acute Respiratory Failure as the First Manifestation of Antisynthetase Syndrome. ( 28638428 )
2017
49
Management Strategies for Severe Respiratory Failure: As Extracorporeal Membrane Oxygenation Is Being Considered. ( 28887928 )
2017
50
Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study. ( 28927683 )
2017
Sources

Variations for Respiratory Failure

About this section

ClinVar genetic disease variations for Respiratory Failure:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 MUSK NM_005592.3(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Likely pathogenic rs751889864 GRCh38 Chromosome 9, 110785664: 110785664
2 MUSK NM_005592.3(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Likely pathogenic rs751889864 GRCh37 Chromosome 9, 113547944: 113547944
3 MUSK NM_005592.3(MUSK): c.2365G> A (p.Gly789Ser) single nucleotide variant Likely pathogenic rs1057518966 GRCh37 Chromosome 9, 113563023: 113563023
4 MUSK NM_005592.3(MUSK): c.2365G> A (p.Gly789Ser) single nucleotide variant Likely pathogenic rs1057518966 GRCh38 Chromosome 9, 110800743: 110800743
5 RYR1 NM_000540.2(RYR1): c.844C> T (p.Arg282Trp) single nucleotide variant Likely pathogenic rs1057518970 GRCh38 Chromosome 19, 38448398: 38448398
6 RYR1 NM_000540.2(RYR1): c.844C> T (p.Arg282Trp) single nucleotide variant Likely pathogenic rs1057518970 GRCh37 Chromosome 19, 38939038: 38939038
7 RYR1 NM_000540.2(RYR1): c.1186G> A (p.Glu396Lys) single nucleotide variant Likely pathogenic rs774919231 GRCh38 Chromosome 19, 38451827: 38451827
8 RYR1 NM_000540.2(RYR1): c.1186G> A (p.Glu396Lys) single nucleotide variant Likely pathogenic rs774919231 GRCh37 Chromosome 19, 38942467: 38942467
9 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
10 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
11 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
12 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
Sources

Expression for Respiratory Failure

About this section
Search GEO for disease gene expression data for Respiratory Failure.
Sources

Pathways for Respiratory Failure

About this section

Pathways related to Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Diseases of metabolism 66
Show member pathways
 11.4 SFTPB SFTPC SFTPD
2
FOXA2 and FOXA3 transcription factor networks 1
10.98 ALB NKX2-1 TTR
3
Surfactant metabolism 66
Show member pathways
 10.77 SFTPB SFTPC SFTPD
4
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 66
Show member pathways
 10.2 SFTPB SFTPC SFTPD
Sources

GO Terms for Respiratory Failure

About this section

Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ALB ALPL ELANE LAMA2 SCGB1A1 SFTPB
2 extracellular space GO:0005615 9.65 ALB ALPL ELANE LAMA2 SCGB1A1 SFTPB
3 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPB SFTPC