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MCID: RSP003
MIFTS: 72

Respiratory Failure

Categories: Blood diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Respiratory Failure

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MalaCards integrated aliases for Respiratory Failure:

Name: Respiratory Failure 12 29 55 43 15 63 73
Acute Respiratory Failure 12 55 15 73
Chronic Respiratory Failure 12 55 73
Respiratory Insufficiency 29 6 73
Acute-on-Chronic Respiratory Failure 12 73
Acute and Chronic Respiratory Failure 12
Chronic Disease of Respiratory System 73
Respiratory Insufficiency/failure 12
Pulmonary Valve Insufficiency 73
Chronic Respiratory Disease 55
Respiratory Tract Diseases 73
Respiration Disorders 73
Respiratory Disease 55

Classifications:

MalaCards categories:
Global: Fetal diseases Infectious diseases Rare diseases
Anatomical: Respiratory diseases Neuronal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Respiratory Failure

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MedlinePlus : 43 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well. Respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs. Diseases and conditions that affect your breathing can cause respiratory failure. Examples include Lung diseases such as COPD (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis Conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage. Drug or alcohol overdose Injuries from inhaling smoke or harmful fumes Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. It also depends on the underlying cause. You may receive oxygen therapy and other treatment to help you breathe. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Respiratory Failure, also known as acute respiratory failure, is related to neonatal respiratory failure and adult respiratory distress syndrome, and has symptoms including dyspnea, edema and respiratory distress. An important gene associated with Respiratory Failure is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Diseases of metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Riluzole and Beractant have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A lung disease characterized by inadequate gas exchange by the respiratory system.

CDC : 3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and “gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

PubMed Health : 63 About respiratory failure: Respiratory (RES-pih-rah-tor-e) failure is a condition in which not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well.Respiratory failure also can occur if your lungs can't properly remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs.Both of these problems—a low oxygen level and a high carbon dioxide level in the blood—can occur at the same time.Diseases and conditions that affect your breathing can cause respiratory failure. Examples include COPD (chronic obstructive pulmonary disease) and spinal cord injuries. COPD prevents enough air from flowing in and out of the airways. Spinal cord injuries can damage the nerves that control breathing.

Wikipedia : 76 Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the... more...

Sources

Related Diseases for Respiratory Failure

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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 818)
# Related Disease Score Top Affiliating Genes
1 neonatal respiratory failure 34.2 SFTPB SFTPC
2 adult respiratory distress syndrome 32.2 ELANE SFTPB SFTPC TNF
3 rigid spine muscular dystrophy 1 31.9 GAA LAMA2 TTN
4 pulmonary fibrosis, idiopathic 31.7 SFTPC SFTPB SCGB1A1 ELANE SFTPD TNF
5 acute respiratory distress syndrome 31.7 TNF SFTPD SFTPC SFTPB ELANE
6 silicosis 31.5 SCGB1A1 SFTPD TNF
7 lung disease 31.4 TNF SFTPD SFTPC SFTPB PDE4A NKX2-1
8 newborn respiratory distress syndrome 30.9 TTN SFTPD SFTPC SFTPB SCGB1A1 IGHMBP2
9 neuromuscular disease 30.6 DCTN1 GAA LAMA2 TTN
10 pneumonia 30.5 TNF SFTPD SFTPC SFTPB PIK3C2A ELANE
11 pulmonary disease, chronic obstructive 30.4 TNF SFTPD SFTPB SCGB1A1 PDE4A ELANE
12 pneumocystosis 30.3 ALB SFTPD TNF
13 bronchopulmonary dysplasia 30.2 ELANE SCGB1A1 SFTPB
14 pulmonary alveolar proteinosis 30.1 SFTPB SFTPC SFTPD
15 interstitial lung disease 30.1 NKX2-1 SFTPB SFTPC SFTPD TNF
16 cardiac arrest 29.9 ALB ELANE PIK3C2A
17 bronchitis 29.9 ALB ELANE TNF
18 aspergillosis 29.8 ELANE SFTPD TNF
19 cardiogenic shock 29.7 PIK3C2A TNF
20 farmer's lung 29.7 ELANE TNF
21 idiopathic interstitial pneumonia 29.7 ELANE SFTPC SFTPD
22 meconium aspiration syndrome 29.7 SCGB1A1 SFTPB TNF
23 diaphragmatic hernia, congenital 29.7 NKX2-1 SFTPB SFTPC
24 burns 29.6 TNF TTR
25 chronic graft versus host disease 29.6 ALB TNF
26 peripheral nervous system disease 29.6 ALB TNF TTN TTR
27 lung cancer susceptibility 3 29.6 NKX2-1 SCGB1A1 SFTPB SFTPC
28 pasteurellosis 29.6 ALB ELANE
29 bacterial pneumonia 29.5 ELANE SFTPB SFTPD
30 pulmonary emphysema 29.5 ELANE SFTPC SFTPD
31 hereditary myopathy with early respiratory failure 12.6
32 hereditary proximal myopathy with early respiratory failure 12.4
33 myopathy, distal, with early respiratory failure, autosomal dominant 12.1
34 spinal muscular atrophy, distal, autosomal recessive, 1 12.0
35 muscular dystrophy, congenital, davignon-chauveau type 11.6
36 amyotrophic lateral sclerosis 1 11.3
37 combined oxidative phosphorylation deficiency 3 11.3
38 acute interstitial pneumonia 11.3
39 alveolar capillary dysplasia 11.3
40 idiopathic acute eosinophilic pneumonia 11.3
41 status asthmaticus 11.2
42 pulmonary edema 11.2
43 short-rib thoracic dysplasia 7 with or without polydactyly 11.1
44 guillain-barre syndrome 11.1
45 thyrotoxic periodic paralysis 11.1
46 central hypoventilation syndrome, congenital 11.1
47 spinal muscular atrophy with respiratory distress type 2 11.1
48 leigh syndrome 11.1
49 bronchiectasis 11.1
50 perry syndrome 11.1

Comorbidity relations with Respiratory Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 118)


Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alcohol Abuse
Alcoholic Cardiomyopathy Alcoholic Liver Cirrhosis
Anthracosis Anxiety
Aortic Aneurysm Aortic Valve Disease 1
Asbestosis Aspergillosis
Asthma Bleeding Disorder, Platelet-Type, 11
Bronchiectasis Bronchitis
Bronchopneumonia Candidiasis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Conjunctivitis
Conn's Syndrome Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Diaphragm Disease
Disseminated Intravascular Coagulation Dysthymic Disorder
Encephalopathy Esophageal Candidiasis
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Goodpasture Syndrome
Guillain-Barre Syndrome, Familial Heart Disease
Hepatic Encephalopathy Hypertension, Essential
Hypertensive Encephalopathy Hypertrophic Cardiomyopathy

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to Respiratory Failure
Sources

Symptoms & Phenotypes for Respiratory Failure

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UMLS symptoms related to Respiratory Failure:


dyspnea, edema, respiratory distress, apnea, hemoptysis, cyanosis, stridor, rhinorrhea, wheezing, inspiratory stridor, snoring, pleuritic pain, coughing, hoarseness, neonatal cyanosis, sore throat, cheyne-stokes respiration, sneezing, expiratory wheeze, labored breathing, inspiratory wheeze, choking sensation, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, anoxemia, sinus congestion, other symptoms involving respiratory system and chest, bronchorrhea, gasping for breath, symptoms involving respiratory system and other chest symptoms, nasal congestion (finding), nasal irritation, neck tightness, larynx pain

GenomeRNAi Phenotypes related to Respiratory Failure according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.2 PIK3C2A
2 Decreased viability GR00106-A-0 10.2 DCTN1
3 Decreased viability GR00221-A-1 10.2 PIK3C2A
4 Decreased viability GR00221-A-2 10.2 PIK3C2A TTN
5 Decreased viability GR00221-A-4 10.2 PIK3C2A TTN
6 Decreased viability GR00231-A 10.2 TK2
7 Decreased viability GR00240-S-1 10.2 PIK3C2A
8 Decreased viability GR00342-S-1 10.2 PIK3C2A TTN
9 Decreased viability GR00342-S-2 10.2 PIK3C2A
10 Decreased viability GR00342-S-3 10.2 PIK3C2A TTN
11 Decreased viability GR00381-A-1 10.2 LAMA2
12 Decreased viability GR00402-S-2 10.2 ALB ALPL CHAT DCTN1 ELANE GAA
13 no effect GR00402-S-1 9.62 ALB ALPL CHAT DCTN1 ELANE GAA

MGI Mouse Phenotypes related to Respiratory Failure:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ALB ALPL CHAT DCTN1 ELANE GAA
2 behavior/neurological MP:0005386 10.32 ALPL CHAT DCTN1 GAA IGHMBP2 LAMA2
3 cardiovascular system MP:0005385 10.31 ALPL CHAT GAA IGHMBP2 NKX2-1 PDE4A
4 growth/size/body region MP:0005378 10.28 ALPL CHAT GAA IGHMBP2 LAMA2 NKX2-1
5 cellular MP:0005384 10.26 ALB ALPL DCTN1 GAA IGHMBP2 LAMA2
6 mortality/aging MP:0010768 10.25 ALB ALPL CHAT DCTN1 ELANE IGHMBP2
7 immune system MP:0005387 10.15 ALPL DCTN1 ELANE LAMA2 PDE4A PIK3C2A
8 digestive/alimentary MP:0005381 10 ALB ALPL CHAT IGHMBP2 NKX2-1 TNF
9 muscle MP:0005369 10 ALB ALPL CHAT DCTN1 GAA IGHMBP2
10 nervous system MP:0003631 9.65 ALPL CHAT DCTN1 IGHMBP2 LAMA2 NKX2-1
11 neoplasm MP:0002006 9.63 ALB ELANE NKX2-1 SCGB1A1 SFTPC TNF
12 respiratory system MP:0005388 9.28 ALPL CHAT IGHMBP2 NKX2-1 SCGB1A1 SFTPB
Sources

Drugs & Therapeutics for Respiratory Failure

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PubMedHealth treatment related to Respiratory Failure: 63

Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and its severity. Treatment also depends on the condition's underlying cause.Acute respiratory failure can be a medical emergency. It often is treated in an intensive care unit at a hospital. Chronic respiratory failure often can be treated at home. If chronic respiratory failure is severe, your doctor may recommend treatment in a long-term care center.One of the main goals of treating respiratory failure is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the underlying cause of the condition.

Drugs for Respiratory Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 593)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Riluzole Approved, Investigational Phase 4,Phase 2,Phase 3 1744-22-5 5070
2 Beractant Approved Phase 4,Phase 3 108778-82-1
3 Poractant alfa Approved Phase 4,Phase 2,Not Applicable 129069-19-8
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6
5
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
6
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
7
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
8 Nefopam Approved, Investigational Phase 4 13669-70-0
9
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
10
Ropivacaine Approved Phase 4,Phase 3,Not Applicable 84057-95-4 175805 71273
11
Clonidine Approved Phase 4 4205-90-7 2803
12
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
13
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
14
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
16
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
18
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
19
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
20
mometasone furoate Approved, Vet_approved Phase 4,Phase 3 83919-23-7
21
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
22
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
24 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25
Remifentanil Approved Phase 4,Phase 1,Not Applicable 132875-61-7 60815
26
Ketamine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 6740-88-1 3821
27
Nitrous oxide Approved, Vet_approved Phase 4,Phase 2,Phase 3 10024-97-2 948
28
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
29
Azithromycin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 83905-01-5 55185 447043
30
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
31
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
32
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
33
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Not Applicable 616-91-1 12035
34
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
35
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
36
Furosemide Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54-31-9 3440
37
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
38
Adenosine Approved, Investigational Phase 4 58-61-7 60961
39
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
40
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
41
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754
42
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
43
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2 50-03-3
44
Ticlopidine Approved Phase 4,Not Applicable 55142-85-3 5472
45
Clopidogrel Approved Phase 4,Not Applicable 113665-84-2, 120202-66-6 60606
46
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
47
Metoprolol Approved, Investigational Phase 4,Phase 3 37350-58-6, 51384-51-1 4171
48
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
49
Ipratropium Approved Phase 4,Not Applicable 60205-81-4, 22254-24-6 43232
50
Citalopram Approved Phase 4 59729-33-8 2771

Interventional clinical trials:

(show top 50) (show all 1744)
# Name Status NCT ID Phase Drugs
1 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
2 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
3 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
4 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
5 Inspiratory Muscle Training in Hypercapnic COPD Unknown status NCT00291460 Phase 4
6 Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Unknown status NCT00560287 Phase 4
7 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
8 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
9 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
10 A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
11 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
12 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
13 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
14 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
15 Influence of Moderate Inspired Oxygen Fraction (FiO2) and Protective Ventilation on Postoperative Pulmonary Complication Unknown status NCT02198625 Phase 4
16 Steroids In caRdiac Surgery Trial (SIRS Trial) Unknown status NCT00427388 Phase 4 Methylprednisolone
17 Acupuncture for Sedation in the Intensive Care Unit (ICU) Unknown status NCT01362270 Phase 4
18 The Effectiveness of Nasal Corticosteroids Versus Placebo in Nasal Obstruction in Patients With Nasal Septal Deviation Unknown status NCT02877485 Phase 4 Triamcinolone Acetonide;Ayr saline nasal mist
19 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
20 Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
21 Helmet Ventilation in Acute Hypercapnic Respiratory Failure Completed NCT01645358 Phase 4
22 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
23 Ambulatory Adaptation to Non-Invasive Mechanical Ventilation Completed NCT00698958 Phase 4
24 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
25 Non-invasive Ventilation in Terminally Ill Cancer Patients Completed NCT00533143 Phase 4
26 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4
27 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
28 Inhaled Nitric Oxide by Oxygen Hood in Neonates Completed NCT00732537 Phase 4 inhaled Nitric Oxide;Oxygen (>90% by hood) - standard therapy
29 Early Application of CPAP in Hematologic Completed NCT00507533 Phase 4
30 Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
31 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
32 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
33 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
34 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients Completed NCT00355732 Phase 4
35 Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients Completed NCT01472302 Phase 4
36 Effect of Neuromuscular Blockade and Reversal on Breathing Completed NCT02845375 Phase 4 Sugammadex;Neostigmine;Placebo
37 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
38 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
39 Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics Completed NCT02363920 Phase 4
40 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
41 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
42 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo
43 Anesthesia for Retinopathy of Prematurity Completed NCT01955135 Phase 4 Ketamine;Sevoflurane;propofol
44 Supplemental Oxygen and Complications After Abdominal Surgery (The PROXI-trial) Completed NCT00364741 Phase 4 Oxygen
45 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4
46 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
47 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
48 Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome Completed NCT02041546 Phase 4 Lung lavage with surfactant;Bolus surfactant
49 Azithromycin in the Prevention of Lung Injury in Premature Newborn Completed NCT03485703 Phase 4 Azithromycin;Placebo
50 Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter Completed NCT01914926 Phase 4 Metoprolol;Diltiazem

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Respiratory Failure

About this section

Genetic tests related to Respiratory Failure:

# Genetic test Affiliating Genes
1 Respiratory Failure 29
2 Respiratory Insufficiency 29
Sources

Anatomical Context for Respiratory Failure

About this section

MalaCards organs/tissues related to Respiratory Failure:

41
Lung, Heart, Brain, Testes, Spinal Cord, Kidney, Liver
Sources

Publications for Respiratory Failure

About this section

Articles related to Respiratory Failure:

(show top 50) (show all 2564)
# Title Authors Year
1
Anti PD-1 immunotherapy related interstitial lung disease presenting as respiratory failure - A review with case series. ( 30456167 )
2019
2
Noninvasive ventilation in acute hypoxemic respiratory failure: A systematic review and meta-analysis. ( 30388493 )
2019
3
Outcomes and Mortality Prediction Model of Critically Ill Adults With Acute Respiratory Failure and Interstitial Lung Disease. ( 29353024 )
2018
4
ABCA3 Deficiency in a Newborn with Respiratory Failure. ( 29970269 )
2018
5
Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation. ( 29973963 )
2018
6
A Prospective Study of Bacteriological Etiology in Hospitalized Acute Exacerbation of COPD Patients: Relationship with Lung Function and Respiratory Failure. ( 29404182 )
2018
7
German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation: Revised Edition 2017 - Part 1. ( 29945148 )
2018
8
Progressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure. ( 29406380 )
2018
9
When Antimicrobial Therapy Is Not Enough: Respiratory Failure in a Patient with Chronic Granulomatous Disease. ( 29714104 )
2018
10
Does Extracorporeal Membrane Oxygenation Improve Survival in Pediatric Acute Respiratory Failure? ( 29373797 )
2018
11
Pediatric Specialty Care Model for Management of Chronic Respiratory Failure: Cost and Savings Implications and Misalignment With Payment Models. ( 29406371 )
2018
12
Pre-stroke undiagnosed dysphagia lusoria as a rare cause of aspiration pneumonia with respiratory failure in a stroke patient. ( 29552342 )
2018
13
High flow nasal cannulae oxygen therapy in acute-moderate hypercapnic respiratory failure. ( 29392846 )
2018
14
Management of adult-onset methylmalonic acidemia with hypotonia and acute respiratory failure: A case report. ( 29924026 )
2018
15
Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients: reply. ( 29943165 )
2018
16
Rare Cause of Respiratory Failure: A Twist in the Tale. ( 29957035 )
2018
17
Respiratory failure in a diabetic ketoacidosis patient with severe hypophosphatemia. ( 29969883 )
2018
18
Inhaled nitric oxide mitigates need for extracorporeal membrane oxygenation in a patient with refractory acute hypoxemic respiratory failure due to cardiac and pulmonary shunts. ( 29977772 )
2018
19
Noninvasive Ventilation for Acute Respiratory Failure due to Noncystic Fibrosis Bronchiectasis. ( 29910541 )
2018
20
Veno-venous extracorporeal membrane oxygenation bridged living-donor lung transplantation for rapid progressive respiratory failure with pleuroparenchymal fibroelastosis after allogeneic hematopoietic stem cell transplantation. ( 29773298 )
2018
21
Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis. ( 29379704 )
2018
22
Noninvasive ventilation for respiratory failure: a note of caution in selected patients. ( 29934923 )
2018
23
What is the Impact of Mildly Altered Consciousness on Acute Hypoxemic Respiratory Failure with Non-invasive ventilation? ( 29434147 )
2018
24
German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation - Revised Edition 2017: Part 2. ( 29945156 )
2018
25
Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. ( 29360422 )
2018
26
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
27
What Can We Apply to Manage Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Respiratory Failure? ( 29372630 )
2018
28
Prognostic factors of noninvasive mechanical ventilation in lung cancer patients with acute respiratory failure. ( 29329356 )
2018
29
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
30
Loss of <i>Atoh1</i> from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. ( 29972353 )
2018
31
Frailty Characteristics Predict Respiratory Failure in Patients Undergoing Tracheobronchoplasty. ( 29959941 )
2018
32
Methotrexate-associated lymphoproliferative disorder complicated by severe acute respiratory failure and ileal perforation: a case report. ( 29925726 )
2018
33
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
34
Effectiveness and Safety of High-Flow Nasal Cannula Oxygen Delivery during Bronchoalveolar Lavage in Acute Respiratory Failure Patients. ( 29926546 )
2018
35
Hypophosphatemia and duration of respiratory failure and mortality in critically ill patients. ( 29687440 )
2018
36
<i>Neisseria meningitidis</i> sepsis in a patient with acute epiglottitis and respiratory failure. ( 29804070 )
2018
37
Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan. ( 29936329 )
2018
38
Is endotracheal intubation a non-beneficial treatment in patients with respiratory failure due to paraquat poisoning? ( 29590187 )
2018
39
Extracorporeal Membrane Oxygenation for Refractory Severe Respiratory Failure in Acute Interstitial Pneumonia. ( 29323413 )
2018
40
Acute Respiratory Failure in Pediatric Hematopoietic Cell Transplantation-A Multicenter Study. ( 29965835 )
2018
41
Double aortic arch presenting as neonatal respiratory failure in the delivery room. ( 29248031 )
2018
42
The ACUTE (Ambulance CPAP: Use, Treatment effect and economics) feasibility study: a pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. ( 29946477 )
2018
43
Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. ( 29415760 )
2018
44
Positive end expiratory pressure in acute hypoxemic respiratory failure due to community acquired pneumonia: do we need a personalized approach? ( 29404202 )
2018
45
Admission volume is associated with mortality of neonatal respiratory failure in emerging neonatal intensive care units. ( 29385861 )
2018
46
Efficacy and Tolerability of High-Flow Nasal Cannula Oxygen Therapy for Hypoxemic Respiratory Failure in Patients with Interstitial Lung Disease with Do-Not-Intubate Orders: A Retrospective Single-Center Study. ( 29954000 )
2018
47
Dyspnea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact - a prospective observational study. ( 29976650 )
2018
48
ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels. ( 30210145 )
2018
49
Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. ( 30095747 )
2018
50
Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. ( 30247273 )
2018
Sources

Variations for Respiratory Failure

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ClinVar genetic disease variations for Respiratory Failure:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 MUSK NM_005592.3(MUSK): c.2365G> A (p.Gly789Ser) single nucleotide variant Likely pathogenic rs1057518966 GRCh37 Chromosome 9, 113563023: 113563023
2 MUSK NM_005592.3(MUSK): c.2365G> A (p.Gly789Ser) single nucleotide variant Likely pathogenic rs1057518966 GRCh38 Chromosome 9, 110800743: 110800743
3 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
4 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
5 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
6 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
7 RYR1 NM_000540.2(RYR1): c.1186G> A (p.Glu396Lys) single nucleotide variant Likely pathogenic rs774919231 GRCh37 Chromosome 19, 38942467: 38942467
8 RYR1 NM_000540.2(RYR1): c.1186G> A (p.Glu396Lys) single nucleotide variant Likely pathogenic rs774919231 GRCh38 Chromosome 19, 38451827: 38451827
9 RYR1 NM_000540.2(RYR1): c.844C> T (p.Arg282Trp) single nucleotide variant Likely pathogenic rs1057518970 GRCh37 Chromosome 19, 38939038: 38939038
10 RYR1 NM_000540.2(RYR1): c.844C> T (p.Arg282Trp) single nucleotide variant Likely pathogenic rs1057518970 GRCh38 Chromosome 19, 38448398: 38448398
11 MUSK NM_005592.3(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Likely pathogenic rs751889864 GRCh37 Chromosome 9, 113547944: 113547944
12 MUSK NM_005592.3(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Likely pathogenic rs751889864 GRCh38 Chromosome 9, 110785664: 110785664
Sources

Expression for Respiratory Failure

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Search GEO for disease gene expression data for Respiratory Failure.
Sources

Pathways for Respiratory Failure

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Pathways related to Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Diseases of metabolism 66
Show member pathways
 11.4 SFTPB SFTPC SFTPD
2
FOXA2 and FOXA3 transcription factor networks 1
10.98 ALB NKX2-1 TTR
3
Surfactant metabolism 66
Show member pathways
 10.77 SFTPB SFTPC SFTPD
4
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 66
Show member pathways
 10.2 SFTPB SFTPC SFTPD
Sources

GO Terms for Respiratory Failure

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Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 ALB ALPL ELANE GAA PIK3C2A SCGB1A1
2 extracellular space GO:0005615 9.81 ALB ALPL ELANE SCGB1A1 SFTPB SFTPC
3 lamellar body GO:0042599 9.37 SFTPB SFTPC
4 extracellular region GO:0005576 9.36 ALB ALPL ELANE LAMA2 SCGB1A1 SFTPB
5 multivesicular body lumen GO:0097486 9.26 SFTPB SFTPC
6 clathrin-coated endocytic vesicle GO:0045334 9.13 SFTPB SFTPC SFTPD

Biological processes related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.58 NKX2-1 SFTPB TNF
2 striated muscle contraction GO:0006941 9.37 GAA TTN
3 response to glucocorticoid GO:0051384 9.33 ALPL SCGB1A1 TNF
4 negative regulation of growth of symbiont in host GO:0044130 9.32 ELANE TNF
5 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.26 ELANE TNF
6 respiratory gaseous exchange GO:0007585 9.13 SFTPB SFTPC SFTPD
7 cellular protein metabolic process GO:0044267 9.02 ALB SFTPB SFTPC SFTPD TTR

Molecular functions related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 ALB SFTPC SFTPD TNF TTN TTR
2 protease binding GO:0002020 8.8 ELANE TNF TTN
Sources

Sources for Respiratory Failure

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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