MCID: RSP003
MIFTS: 74

Respiratory Failure

Categories: Blood diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Respiratory Failure

MalaCards integrated aliases for Respiratory Failure:

Name: Respiratory Failure 12 29 54 6 42 15 62 17 71
Acute Respiratory Failure 12 54 15 71 32
Chronic Respiratory Failure 12 54 71 32
Respiratory Insufficiency 29 6 71
Acute-on-Chronic Respiratory Failure 12 71
Acute and Chronic Respiratory Failure 12
Chronic Disease of Respiratory System 71
Respiratory Insufficiency/failure 12
Pulmonary Valve Insufficiency 71
Chronic Respiratory Disease 54
Respiratory Tract Diseases 71
Respiration Disorders 71
Respiratory Disease 54

Classifications:



External Ids:

Disease Ontology 12 DOID:11162
ICD9CM 34 518.81
NCIt 49 C27043
SNOMED-CT 67 65710008
UMLS 71 C0034088 C0035204 C0035229 more

Summaries for Respiratory Failure

MedlinePlus : 42 What is respiratory failure? Respiratory failure is a condition in which your blood doesn't have enough oxygen or has too much carbon dioxide. Sometimes you can have both problems. When you breathe, your lungs take in oxygen. The oxygen passes into your blood, which carries it to your organs. Your organs, such as your heart and brain, need this oxygen-rich blood to work well. Another part of breathing is removing the carbon dioxide from the blood and breathing it out. Having too much carbon dioxide in your blood can harm your organs. What causes respiratory failure? Conditions that affect your breathing can cause respiratory failure. These conditions may affect the muscles, nerves, bones, or tissues that support breathing. Or they may affect the lungs directly. These conditions include Lung diseases such as COPD (chronic obstructive pulmonary disease), cystic fibrosis, pneumonia, and pulmonary embolism Conditions that affect the nerves and muscles that control breathing, such as amyotrophic lateral sclerosis (ALS), muscular dystrophy, spinal cord injuries, and stroke Problems with the spine, such as scoliosis (a curve in the spine). They can affect the bones and muscles used for breathing. Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage. Drug or alcohol overdose Inhalation injuries, such as from inhaling smoke (from fires) or harmful fumes What are the symptoms of respiratory failure? The symptoms of respiratory failure depend on the cause and the levels of oxygen and carbon dioxide in your blood. A low oxygen level in the blood can cause shortness of breath and air hunger (the feeling that you can't breathe in enough air). Your skin, lips, and fingernails may also have a bluish color. A high carbon dioxide level can cause rapid breathing and confusion. Some people who have respiratory failure may become very sleepy or lose consciousness. They also may have arrhythmia (irregular heartbeat). You may have these symptoms if your brain and heart are not getting enough oxygen. How is respiratory failure diagnosed? Your health care provider will diagnose respiratory failure based on Your medical history A physical exam, which often includes Listening to your lungs to check for abnormal sounds Listening to your heart to check for arrhythmia Looking for a bluish color on your skin, lips, and fingernails Diagnostic tests, such as Pulse oximetry, a small sensor that uses a light to measure how much oxygen is in your blood. The sensor goes on the end of your finger or on your ear. Arterial blood gas test, a test that measures the oxygen and carbon dioxide levels in your blood. The blood sample is taken from an artery, usually in your wrist. Once you are diagnosed with respiratory failure, your provider will look for what is causing it. Tests for this often include a chest x-ray. If your provider thinks you may have arrhythmia because of the respiratory failure, you may have an EKG (electrocardiogram). This is simple, painless test that detects and records your heart's electrical activity. What are the treatments for respiratory failure? Treatment for respiratory failure depends on Whether it is acute (short-term) or chronic (ongoing) How severe it is What is causing it Acute respiratory failure can be a medical emergency. You may need treatment in intensive care unit at a hospital. Chronic respiratory failure can often be treated at home. But if your chronic respiratory failure is severe, you might need treatment in a long-term care center. One of the main goals of treatment is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the cause of the condition. Treatments may include Oxygen therapy, through a nasal cannula (two small plastic tubes that go in your nostrils) or through a mask that fits over your nose and mouth Tracheostomy, a surgically-made hole that goes through the front of your neck and into your windpipe. A breathing tube, also called a tracheostomy, or trach tube, is placed in the hole to help you breathe. Ventilator, a breathing machine that blows air into your lungs. It also carries carbon dioxide out of your lungs. Other breathing treatments, such as noninvasive positive pressure ventilation (NPPV), which uses mild air pressure to keep your airways open while you sleep. Another treatment is a special bed that rocks back and forth, to help you breathe in and out. Fluids, often through an intravenous (IV), to improve blood flow throughout your body. They also provide nutrition. Medicines for discomfort Treatments for the cause of the respiratory failure. These treatments may include medicines and procedures. If you have respiratory failure, see your health care provider for ongoing medical care. Your provider may suggest pulmonary rehabilitation. If your respiratory failure is chronic, make sure that you know when and where to get help for your symptoms. You need emergency care if you have severe symptoms, such as trouble catching your breath or talking. You should call your provider if you notice that your symptoms are worsening or if you have new signs and symptoms. Living with respiratory failure may cause fear, anxiety, depression, and stress. Talk therapy, medicines, and support groups can help you feel better. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Respiratory Failure, also known as acute respiratory failure, is related to neonatal respiratory failure and adult respiratory distress syndrome, and has symptoms including dyspnea, edema and respiratory distress. An important gene associated with Respiratory Failure is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Sufentanil and Oseltamivir have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A lung disease characterized by inadequate gas exchange by the respiratory system.

PubMed Health : 62 About respiratory failure: Respiratory (RES-pih-rah-tor-e) failure is a condition in which not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well. Respiratory failure also can occur if your lungs can't properly remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs. Both of these problems—a low oxygen level and a high carbon dioxide level in the blood—can occur at the same time. Diseases and conditions that affect your breathing can cause respiratory failure. Examples include COPD (chronic obstructive pulmonary disease) and spinal cord injuries. COPD prevents enough air from flowing in and out of the airways. Spinal cord injuries can damage the nerves that control breathing.

Wikipedia : 74 Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the... more...

Related Diseases for Respiratory Failure

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1572)
# Related Disease Score Top Affiliating Genes
1 neonatal respiratory failure 35.0 SFTPD SFTPC SFTPB NKX2-1 ABCA3
2 adult respiratory distress syndrome 33.3 SFTPD SFTPC SFTPB ELANE
3 acute interstitial pneumonia 33.2 SFTPD SFTPC SFTPB
4 lung disease 33.1 SFTPD SFTPC SFTPB SCGB1A1 PDE4A NKX2-1
5 pulmonary fibrosis, idiopathic 33.1 SFTPD SFTPC SFTPB SCGB1A1 ELANE ALB
6 surfactant dysfunction 33.0 SFTPC SFTPB ABCA3
7 pulmonary fibrosis 33.0 SFTPD SFTPC ELANE ABCA3
8 newborn respiratory distress syndrome 32.8 TTN SFTPD SFTPC SFTPB SCGB1A1 NKX2-1
9 surfactant metabolism dysfunction, pulmonary, 1 32.6 SFTPB ABCA3
10 pulmonary disease, chronic obstructive 32.3 TTN SFTPD SFTPB SCGB1A1 PDE4A ELANE
11 bronchopulmonary dysplasia 31.9 SFTPB SCGB1A1 ELANE
12 neuromuscular disease 31.9 TTN IGHMBP2 GAA DCTN1 CHAT ALB
13 meconium aspiration syndrome 31.8 TTN SFTPB SCGB1A1
14 pneumonia 31.8 TTR SFTPD SFTPC SFTPB SCGB1A1 PIK3C2A
15 diaphragmatic hernia, congenital 31.8 SFTPC SFTPB NKX2-1
16 idiopathic interstitial pneumonia 31.7 SFTPD SFTPC SFTPB ELANE
17 cardiac arrest 31.6 TTN PIK3C2A ELANE ALB
18 interstitial lung disease 31.6 TNFRSF13B SFTPD SFTPC SFTPB NKX2-1 INPP5E
19 bacterial pneumonia 31.6 SFTPD SFTPB SCGB1A1 ELANE ALB
20 aspiration pneumonia 31.4 PIK3C2A CHAT ALB
21 pulmonary emphysema 31.3 SFTPD SFTPC ELANE ALB
22 pulmonary hypertension 31.3 SFTPC PDE4A ELANE ALB
23 pulmonary alveolar proteinosis 31.2 SFTPD SFTPC SFTPB
24 respiratory distress syndrome in premature infants 31.1 SFTPC SFTPB NKX2-1 ABCA3
25 interstitial emphysema 31.1 TTN SFTPC SFTPB ABCA3
26 atrial standstill 1 31.0 TTR TTN GAA
27 bronchial disease 31.0 PDE4A ELANE ALB
28 endocarditis 30.9 TTR PIK3C2A ALB
29 tracheal agenesis 30.9 SFTPD SFTPB
30 extrinsic allergic alveolitis 30.9 SFTPD ELANE ALB
31 mediastinitis 30.9 TTR ALB
32 pericardial effusion 30.9 TTR PIK3C2A ALB
33 pasteurellosis 30.8 ELANE ALB
34 constrictive pericarditis 30.7 TTN ALB
35 lung benign neoplasm 30.6 SFTPC SCGB1A1 NKX2-1
36 pulmonary immaturity 30.6 SFTPD SFTPC SFTPB ABCA3
37 interstitial pneumonitis, desquamative, familial 30.6 SFTPD SFTPC SFTPB ABCA3
38 pulmonary hypertension, primary, 1 30.6 PMS2 ABCA3
39 cryptogenic organizing pneumonia 30.6 SFTPD SFTPC
40 miyoshi muscular dystrophy 30.5 TTN PIK3C2A GAA
41 paraquat lung 30.5 SFTPB SCGB1A1
42 diffuse pulmonary fibrosis 30.4 SFTPC ABCA3
43 muscular disease 30.3 TTR TTN PIK3C2A IGHMBP2 GAA ALB
44 nonspecific interstitial pneumonia 30.3 SFTPD SFTPC ABCA3
45 creatine phosphokinase, elevated serum 30.2 PIK3C2A GAA
46 myopathy, myofibrillar, 9, with early respiratory failure 12.9
47 hereditary proximal myopathy with early respiratory failure 12.6
48 spinal muscular atrophy, distal, autosomal recessive, 1 12.3
49 rare genetic respiratory disease 12.1
50 rare allergic respiratory disease 12.1

Comorbidity relations with Respiratory Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 111)


Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alcoholic Cardiomyopathy
Alcoholic Liver Cirrhosis Anthracosis
Anxiety Aortic Aneurysm
Aortic Valve Disease 1 Asbestosis
Aspergillosis Asthma
Bleeding Disorder, Platelet-Type, 11 Bronchiectasis
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Chronic Pulmonary Heart Disease
Conjunctivitis Conn's Syndrome
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Diaphragm Disease Disseminated Intravascular Coagulation
Dysthymic Disorder Encephalopathy
Esophageal Candidiasis Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Goodpasture Syndrome Guillain-Barre Syndrome, Familial
Heart Disease Hepatic Encephalopathy
Hypertension, Essential Hypertensive Encephalopathy
Hypertrophic Cardiomyopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to Respiratory Failure

Symptoms & Phenotypes for Respiratory Failure

UMLS symptoms related to Respiratory Failure:


dyspnea, edema, respiratory distress, apnea, hemoptysis, cyanosis, stridor, wheezing, snoring, rhinorrhea, inspiratory stridor, sore throat, cheyne-stokes respiration, coughing, hoarseness, anoxemia, labored breathing, sneezing, expiratory wheeze, inspiratory wheeze, choking sensation, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, pleuritic pain, sinus congestion, other symptoms involving respiratory system and chest, bronchorrhea, neonatal cyanosis, gasping for breath, symptoms involving respiratory system and other chest symptoms, nasal congestion (finding), nasal irritation, neck tightness, larynx pain

GenomeRNAi Phenotypes related to Respiratory Failure according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.39 PIK3C2A
2 Decreased viability GR00106-A-0 10.39 DCTN1
3 Decreased viability GR00221-A-1 10.39 PIK3C2A
4 Decreased viability GR00221-A-2 10.39 PIK3C2A TTN
5 Decreased viability GR00221-A-4 10.39 PIK3C2A TTN
6 Decreased viability GR00240-S-1 10.39 PIK3C2A
7 Decreased viability GR00342-S-1 10.39 PIK3C2A TTN
8 Decreased viability GR00342-S-2 10.39 PIK3C2A
9 Decreased viability GR00342-S-3 10.39 PIK3C2A TTN
10 Decreased viability GR00381-A-1 10.39 TNFRSF13B
11 Decreased viability GR00402-S-2 10.39 ABCA3 ALB CHAT DCTN1 ELANE GAA
12 no effect GR00402-S-1 9.96 ABCA3 ALB CHAT DCTN1 ELANE GAA
13 Reduced mammosphere formation GR00396-S 9.17 ALB DCTN1 GAA PDE4A PIK3C2A TNFRSF13B

MGI Mouse Phenotypes related to Respiratory Failure:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ABCA3 ALB CHAT DCTN1 ELANE GAA
2 cardiovascular system MP:0005385 10.26 ABCA3 ALB CHAT GAA IGHMBP2 NKX2-1
3 mortality/aging MP:0010768 10.25 ABCA3 ALB CHAT DCTN1 ELANE IGHMBP2
4 cellular MP:0005384 10.2 ALB DCTN1 GAA IGHMBP2 INPP5E NKX2-1
5 immune system MP:0005387 10.15 ALB DCTN1 ELANE PDE4A PIK3C2A PMS2
6 digestive/alimentary MP:0005381 9.98 ALB CHAT IGHMBP2 INPP5E NKX2-1 PMS2
7 muscle MP:0005369 9.8 ALB CHAT DCTN1 GAA IGHMBP2 SLC4A1
8 neoplasm MP:0002006 9.7 ALB ELANE NKX2-1 PMS2 SCGB1A1 SFTPC
9 renal/urinary system MP:0005367 9.56 ABCA3 ALB INPP5E PIK3C2A SCGB1A1 SLC4A1
10 respiratory system MP:0005388 9.23 ABCA3 CHAT IGHMBP2 NKX2-1 SCGB1A1 SFTPB

Drugs & Therapeutics for Respiratory Failure

PubMed Health treatment related to Respiratory Failure: 62

Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and its severity. Treatment also depends on the condition's underlying cause. Acute respiratory failure can be a medical emergency. It often is treated in an intensive care unit at a hospital. Chronic respiratory failure often can be treated at home. If chronic respiratory failure is severe, your doctor may recommend treatment in a long-term care center. One of the main goals of treating respiratory failure is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the underlying cause of the condition.

Drugs for Respiratory Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 614)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Oseltamivir Approved Phase 4 196618-13-0, 204255-11-8 65028
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
8
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
9
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
10
Bromhexine Approved Phase 4 3572-43-8
11
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
12
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
13
Ipratropium Approved, Experimental Phase 4 22254-24-6, 60205-81-4 43232 657309
14
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
15
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
16
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
17
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
18
Adenosine Approved, Investigational Phase 4 58-61-7 60961
19
Citalopram Approved Phase 4 59729-33-8 2771
20
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
21
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
22
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
23
Ciclesonide Approved, Investigational Phase 4 126544-47-6, 141845-82-1 444033
24
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
25
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
26
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
27
Ceftazidime Approved Phase 4 72558-82-8, 78439-06-2 5481173
28
Avibactam Approved Phase 4 1192500-31-4
29
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
30
Orphenadrine Approved Phase 4 83-98-7 4601
31
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
32
Cisatracurium Approved Phase 4 96946-41-7
33
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
34
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
35
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
36
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
37
Meperidine Approved Phase 4 57-42-1 4058
38
Sucralfate Approved Phase 4 54182-58-0
39
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
40
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
41
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
42
Polyestradiol phosphate Approved Phase 4 28014-46-2
43
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
44
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
45
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
46
Remifentanil Approved Phase 4 132875-61-7 60815
47
Piperacillin Approved Phase 4 66258-76-2 43672
48
Tazobactam Approved Phase 4 89786-04-9 123630
49
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
50
Loxapine Approved Phase 4 1977-10-2 3964

Interventional clinical trials:

(show top 50) (show all 2568)
# Name Status NCT ID Phase Drugs
1 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
2 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
3 A Pilot Study: Comparing Physiological Parameters and Outcome Variables Using Pressure Support Ventilation Versus Pressure Controlled Ventilation in Patients With Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
4 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
5 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
6 Role of Non-invasive Ventilation in Amyotrophic Lateral Sclerosis: Volume Versus Pressure Mode Unknown status NCT00560287 Phase 4
7 Randomized Controlled Trial of Inspiratory Muscle Training in Patients With Stable Hypercapnic Respiratory Failure Due to COPD Unknown status NCT00291460 Phase 4
8 Phase 4, Single Centre, Single Blinded,Prospective Randomised Cross Over Comparison on the Physiological Response of Post Extubation Intensive Care Patients to Non-invasive Ventilation Using Either Air O2 or Heliox21 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
9 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
10 Comparison of Different Methodologies Assessing Airway Responsiveness and Investigation of Treatment Efficacy of Budesonide /Formoterol in Asthmatics Unknown status NCT02574975 Phase 4 methacholine;adenosine monophosphate;leukotriene D4;budesonide /formoterol
11 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
12 Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial Unknown status NCT01319643 Phase 4 Oxygen
13 CPAP Application at Delivery Room at Very Low Birth Weight Infants Unknown status NCT01024361 Phase 4
14 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
15 Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections. Can Measurement of Procalcitonin Reduce the Use of Antibiotics? Unknown status NCT02171338 Phase 4
16 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Chronic Obstructive Pulmonary Disease Phenotype Unknown status NCT01431625 Phase 4
17 A Randomized Controlled Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
18 Acupuncture for Sedation in the Intensive Care Unit Unknown status NCT01362270 Phase 4
19 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
20 Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia Unknown status NCT01703130 Phase 4
21 Phase IV Study of Perioperative Steroid's Effects on Death or MI in High-Risk Patients Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass Unknown status NCT00427388 Phase 4 Methylprednisolone
22 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
23 Continuous Positive Airway Pressure for Treatment of Postoperative Hypoxemia in Liver Transplant Unknown status NCT00510770 Phase 4
24 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
25 Effect of Vaxoral® (OM-85) on Frequency of Respiratory Tract Infections and Size of Adenoid Tissue in Preschool Children With Adenoid Hypertrophy Unknown status NCT03243565 Phase 4
26 Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis Unknown status NCT01216553 Phase 4
27 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
28 A Randomized Trial to Compare the Effectiveness of Hospital or Ambulatory Approach for Adaptation to Non-Invasive Mechanical Ventilation in Patients With Chronic Respiratory Failure Secondary to Neuromuscular Diseases or Thoracic Cage Alterations Completed NCT00698958 Phase 4
29 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
30 Non-Positive Pressure Ventilation in Hypoxemic Patients. A Randomized Study Completed NCT00925860 Phase 4
31 Hypercapnic Acute Respiratory Failure: Is the Helmet an Effective Interface?" Completed NCT01645358 Phase 4
32 Effects of Remifentanil on Breathing Pattern, Respiratory Effort and Gas Exchange in Mechanically Ventilated Patients. Completed NCT00665119 Phase 4 remifentanil;placebo
33 High-assistance Proportional Assist Ventilation (PAV) vs. Assist-Control Ventilation (ACV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
34 Patients-ventilator Interaction During Sleep: the Role of Humidification. A Pilot Short Term Study Completed NCT01038791 Phase 4
35 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of YMC026 in Respiratory Disease Patients With Cough and Sputum as the Main Symptoms Completed NCT03334916 Phase 4 YMC026;Placebo
36 Does a Diagnostic Strategy Reduce Duration and Cost of Hospitalization in Patients With Acute Dyspnea? BASEL II Intensive Care Unit Completed NCT00130559 Phase 4
37 The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases Completed NCT01867281 Phase 4 aspirin
38 A Randomized Controlled Trial Comparing Two Protocols to Withdraw Non-invasive Ventilation (NIV) After an Episode of Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
39 Study to Evaluate the Effect of Roflumilast 500 μg on Exacerbation Rate in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Treated With a Fixed-Dose Combination of Long-Acting Beta Agonist and Inhaled Corticosteroid (LABA/ICS) Completed NCT01443845 Phase 4 Roflumilast;Placebo
40 Multicenter, Randomised Study of the Use of Non-Invasive Ventilation (NIV) Versus Oxygen Therapy (O2) in Reducing Dyspnea in End-stage Solid Cancer Patients With Respiratory Failure and Distress Completed NCT00533143 Phase 4
41 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
42 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation. Randomized Clinical Trial Completed NCT02526862 Phase 4
43 Early Application of CPAP in Hematologic Neutropenic Patients Avoid Acute Respiratory Failure Completed NCT00507533 Phase 4
44 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation: The PrePARE Trial Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
45 Recruitment Maneuver Increases Oxygenation After Intubation in Hypoxemic ICU Patients: a Randomized Controlled Study Completed NCT01014299 Phase 4
46 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
47 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
48 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
49 Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial Completed NCT01472302 Phase 4
50 Effect of Neuromuscular Blockade and Reversal by Sugammadex Versus Neostigmine on Breathing When Hypoxic or Hypercapnic in Volunteers Completed NCT02845375 Phase 4 Sugammadex;Neostigmine;Placebo

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Glycopyrrolate
nalmefene
Nalmefene hydrochloride
Naloxone Hydrochloride
Oxygen
prednisolone
prednisolone acetate
PREDNISOLONE ACETATE PWDR
PREDNISOLONE PWDR
Prednisolone sodium phosphate
prednisolone tebutate
Prednisone
PREDNISONE PWDR

Genetic Tests for Respiratory Failure

Genetic tests related to Respiratory Failure:

# Genetic test Affiliating Genes
1 Respiratory Insufficiency 29
2 Respiratory Failure 29

Anatomical Context for Respiratory Failure

MalaCards organs/tissues related to Respiratory Failure:

40
Lung, Heart, Testes, Brain, Liver, Bone, Kidney

Publications for Respiratory Failure

Articles related to Respiratory Failure:

(show top 50) (show all 29372)
# Title Authors PMID Year
1
Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. 54 61
19824815 2010
2
Inherited surfactant deficiency caused by uniparental disomy of rare mutations in the surfactant protein-B and ATP binding cassette, subfamily a, member 3 genes. 54 61
19647838 2009
3
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model. 54 61
19539245 2009
4
Interfamilial phenotypic heterogeneity in SMARD1. 54 61
19157874 2009
5
Association of polymorphisms in the human surfactant protein-D (SFTPD) gene and postnatal pulmonary adaptation in the preterm infant. 54 61
18785967 2009
6
[Lung diseases associated with inherited disorders of surfactant metabolism]. 54 61
18804975 2008
7
Surfactant protein B deficiency caused by a novel mutation involving multiple exons of the SP-B gene. 54 61
18558554 2008
8
Clinical and mutational profile in spinal muscular atrophy with respiratory distress (SMARD): defining novel phenotypes through hierarchical cluster analysis. 54 61
17431882 2007
9
Lung specific developmental expression of the Xenopus laevis surfactant protein C and B genes. 54 61
16798105 2007
10
Adult glycogenosis type II (Pompe's disease): morphological abnormalities in muscle and skin biopsies compared with acid alpha-glucosidase activity. 54 61
18176891 2007
11
Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: clinical features and evaluation. 54 61
17142157 2006
12
Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. 54 61
16763223 2006
13
Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. 54 61
17011330 2006
14
Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. 54 61
16912630 2006
15
Surfactant protein B deficiency: a rare cause of respiratory failure in a Lebanese newborn. 54 61
16521884 2006
16
Reversibility of lung inflammation caused by SP-B deficiency. 54 61
16024721 2005
17
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 54 61
16005263 2005
18
Interstitial lung disease in children -- genetic background and associated phenotypes. 54 61
15819986 2005
19
[Neonatal respiratory failure associated with mutation in the surfactant protein C gene]. 54 61
15737281 2005
20
Actin mutations are one cause of congenital fibre type disproportion. 54 61
15468086 2004
21
C-reactive protein and body mass index predict outcome in end-stage respiratory failure. 54 61
15302742 2004
22
[Surfactant-associated proteins B and C: molecular biology and physiologic properties]. 54 61
15229816 2004
23
Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. 54 61
15190959 2004
24
Allelic heterogeneity of SMARD1 at the IGHMBP2 locus. 54 61
15108294 2004
25
Surfactant protein B deficiency in infants with respiratory failure. 54 61
15027668 2004
26
Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. 54 61
13129928 2003
27
Severe infantile neuropathy with diaphragmatic weakness and its relationship to SMARD1. 54 61
14506069 2003
28
[Respiratory diseases associated to surfactant proteins B and C deficiency]. 54 61
15279365 2003
29
Genetic influences and neonatal lung disease. 54 61
12667827 2003
30
Article reviewed: Sleep-disordered breathing and respiratory failure in acid maltase deficiency. 54 61
14592241 2002
31
Sleep-disordered breathing and respiratory failure in acid maltase deficiency. 54 61
11591850 2001
32
Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure. 54 61
11520731 2001
33
CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. 54 61
10934091 2000
34
Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure. 54 61
10931427 2000
35
Pulmonary surfactant metabolism in infants lacking surfactant protein B. 54 61
10696076 2000
36
Recurrent familial neonatal deaths: hereditary surfactant protein B deficiency. 54 61
11041444 2000
37
Hereditary surfactant protein B deficiency resulting from a novel mutation. 54 61
10663288 2000
38
Inhibition of lung surfactant protein B expression during Pneumocystis carinii pneumonia in mice. 54 61
10235125 1999
39
Surfactant protein B deficiency: clinical, histological and molecular evaluation. 54 61
10365365 1999
40
Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency. 54 61
10571948 1999
41
Clearance of Clara cell secretory protein 16 (CC16) and surfactant proteins A and B from blood in acute respiratory failure. 54 61
9817704 1998
42
A 60-year-old woman with weakness, fatigue, and acute respiratory failure: case report and discussion of the differential diagnosis. 54 61
9795552 1998
43
Regulation and function of pulmonary surfactant protein B. 54 61
9758711 1998
44
Deletion of thyroid transcription factor-1 gene in an infant with neonatal thyroid dysfunction and respiratory failure. 54 61
9565498 1998
45
Transient surfactant protein B deficiency in a term infant with severe respiratory failure. 54 61
9506635 1998
46
An early onset muscular dystrophy with diaphragmatic involvement, early respiratory failure and secondary alpha2 laminin deficiency unlinked to the LAMA2 locus on 6q22. 54 61
10726842 1998
47
[Chronic respiratory failure in a case with juvenile-onset acid alpha-glucosidase deficiency; successful therapy with nasal intermittent positive pressure ventilation (NIPPV)]. 54 61
8986097 1997
48
Structure and function of the band 3 Cl-/HCO3- transporter in chronic respiratory failure patients. 54 61
9275335 1996
49
[The effect of furosemide and valium on band 3 protein anion transport function in chronic respiratory failure patients]. 54 61
8762500 1995
50
[A study on erythrocyte membrane band 3 protein anion transport function in chronic respiratory failure patients]. 54 61
8697912 1995

Variations for Respiratory Failure

ClinVar genetic disease variations for Respiratory Failure:

6 (show all 13) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PMS2 NM_000535.7(PMS2):c.1927C>T (p.Gln643Ter)SNV Pathogenic 91320 rs63751422 7:6026469-6026469 7:5986838-5986838
2 CHAT NM_020549.4(CHAT):c.2081C>G (p.Ser694Cys)SNV Pathogenic 523529 rs201439531 10:50872926-50872926 10:49664880-49664880
3 ABCA3 NM_001089.3(ABCA3):c.875A>T (p.Glu292Val)SNV Pathogenic/Likely pathogenic 203381 rs149989682 16:2367764-2367764 16:2317763-2317763
4 INPP5E NM_019892.6(INPP5E):c.1132C>T (p.Arg378Cys)SNV Pathogenic/Likely pathogenic 400 rs121918130 9:139327634-139327634 9:136433182-136433182
5 TNFRSF13B NM_012452.2(TNFRSF13B):c.310T>C (p.Cys104Arg)SNV risk factor 5302 rs34557412 17:16852187-16852187 17:16948873-16948873
6 MUSK NM_005592.4(MUSK):c.1724T>C (p.Ile575Thr)SNV Likely pathogenic 190467 rs751889864 9:113547944-113547944 9:110785664-110785664
7 MUSK NM_005592.4(MUSK):c.2365G>A (p.Gly789Ser)SNV Likely pathogenic 374195 rs1057518966 9:113563023-113563023 9:110800743-110800743
8 RYR1 NM_000540.2(RYR1):c.1186G>A (p.Glu396Lys)SNV Likely pathogenic 374199 rs774919231 19:38942467-38942467 19:38451827-38451827
9 CHAT NM_020549.4(CHAT):c.1061C>T (p.Thr354Met)SNV Conflicting interpretations of pathogenicity 523528 rs769234940 10:50835781-50835781 10:49627735-49627735
10 RYR1 NM_000540.2(RYR1):c.844C>T (p.Arg282Trp)SNV Conflicting interpretations of pathogenicity 374200 rs1057518970 19:38939038-38939038 19:38448398-38448398
11 VANGL1 NM_138959.3(VANGL1):c.523C>T (p.Arg175Trp)SNV Uncertain significance 167818 rs142594314 1:116206600-116206600 1:115663979-115663979
12 GATA4 NM_002052.5(GATA4):c.94G>C (p.Ala32Pro)SNV Uncertain significance 599008 rs773545065 8:11565915-11565915 8:11708406-11708406
13 ERF NM_006494.4(ERF):c.1636C>T (p.Arg546Ter)SNV Uncertain significance 599007 rs764412749 19:42752628-42752628 19:42248476-42248476

Expression for Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for Respiratory Failure

Pathways related to Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.4 SFTPD SFTPC SFTPB
2 10.98 TTR NKX2-1 ALB
3
Show member pathways
10.56 SFTPD SFTPC SFTPB ABCA3
4
Show member pathways
10.53 SFTPD SFTPC SFTPB

GO Terms for Respiratory Failure

Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 TTR SFTPD SFTPC SFTPB SCGB1A1 ELANE
2 lamellar body GO:0042599 9.26 SFTPC SFTPB
3 multivesicular body lumen GO:0097486 9.16 SFTPC SFTPB
4 alveolar lamellar body GO:0097208 8.96 SFTPB ABCA3
5 clathrin-coated endocytic vesicle GO:0045334 8.8 SFTPD SFTPC SFTPB

Biological processes related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 striated muscle contraction GO:0006941 9.16 TTN GAA
2 respiratory gaseous exchange GO:0007585 9.13 SFTPD SFTPC SFTPB
3 cellular protein metabolic process GO:0044267 9.1 TTR SFTPD SFTPC SFTPB ALB ABCA3

Sources for Respiratory Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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