Respiratory Failure

Categories: Blood diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Respiratory Failure

MalaCards integrated aliases for Respiratory Failure:

Name: Respiratory Failure 12 29 55 6 43 15 63 17 72
Acute Respiratory Failure 12 55 15 72 33
Chronic Respiratory Failure 12 55 72 33
Respiratory Insufficiency 29 6 72
Acute-on-Chronic Respiratory Failure 12 72
Acute and Chronic Respiratory Failure 12
Chronic Disease of Respiratory System 72
Respiratory Insufficiency/failure 12
Pulmonary Valve Insufficiency 72
Chronic Respiratory Disease 55
Respiratory Tract Diseases 72
Respiration Disorders 72
Respiratory Disease 55


External Ids:

Disease Ontology 12 DOID:11162
ICD9CM 35 518.81
NCIt 50 C27043
SNOMED-CT 68 65710008
UMLS 72 C0034088 C0035204 C0035229 more

Summaries for Respiratory Failure

MedlinePlus : 43 What is respiratory failure? Respiratory failure is a condition in which your blood doesn't have enough oxygen or has too much carbon dioxide. Sometimes you can have both problems. When you breathe, your lungs take in oxygen. The oxygen passes into your blood, which carries it to your organs. Your organs, such as your heart and brain, need this oxygen-rich blood to work well. Another part of breathing is removing the carbon dioxide from the blood and breathing it out. Having too much carbon dioxide in your blood can harm your organs. What causes respiratory failure? Conditions that affect your breathing can cause respiratory failure. These conditions may affect the muscles, nerves, bones, or tissues that support breathing. Or they may affect the lungs directly. These conditions include Lung diseases such as COPD (chronic obstructive pulmonary disease), cystic fibrosis, pneumonia, and pulmonary embolism Conditions that affect the nerves and muscles that control breathing, such as amyotrophic lateral sclerosis (ALS), muscular dystrophy, spinal cord injuries, and stroke Problems with the spine, such as scoliosis (a curve in the spine). They can affect the bones and muscles used for breathing. Damage to the tissues and ribs around the lungs. An injury to the chest can cause this damage. Drug or alcohol overdose Inhalation injuries, such as from inhaling smoke (from fires) or harmful fumes What are the symptoms of respiratory failure? The symptoms of respiratory failure depend on the cause and the levels of oxygen and carbon dioxide in your blood. A low oxygen level in the blood can cause shortness of breath and air hunger (the feeling that you can't breathe in enough air). Your skin, lips, and fingernails may also have a bluish color. A high carbon dioxide level can cause rapid breathing and confusion. Some people who have respiratory failure may become very sleepy or lose consciousness. They also may have arrhythmia (irregular heartbeat). You may have these symptoms if your brain and heart are not getting enough oxygen. How is respiratory failure diagnosed? Your health care provider will diagnose respiratory failure based on Your medical history A physical exam, which often includes Listening to your lungs to check for abnormal sounds Listening to your heart to check for arrhythmia Looking for a bluish color on your skin, lips, and fingernails Diagnostic tests, such as Pulse oximetry, a small sensor that uses a light to measure how much oxygen is in your blood. The sensor goes on the end of your finger or on your ear. Arterial blood gas test, a test that measures the oxygen and carbon dioxide levels in your blood. The blood sample is taken from an artery, usually in your wrist. Once you are diagnosed with respiratory failure, your provider will look for what is causing it. Tests for this often include a chest x-ray. If your provider thinks you may have arrhythmia because of the respiratory failure, you may have an EKG (electrocardiogram). This is simple, painless test that detects and records your heart's electrical activity. What are the treatments for respiratory failure? Treatment for respiratory failure depends on Whether it is acute (short-term) or chronic (ongoing) How severe it is What is causing it Acute respiratory failure can be a medical emergency. You may need treatment in intensive care unit at a hospital. Chronic respiratory failure can often be treated at home. But if your chronic respiratory failure is severe, you might need treatment in a long-term care center. One of the main goals of treatment is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the cause of the condition. Treatments may include Oxygen therapy, through a nasal cannula (two small plastic tubes that go in your nostrils) or through a mask that fits over your nose and mouth Tracheostomy, a surgically-made hole that goes through the front of your neck and into your windpipe. A breathing tube, also called a tracheostomy, or trach tube, is placed in the hole to help you breathe. Ventilator, a breathing machine that blows air into your lungs. It also carries carbon dioxide out of your lungs. Other breathing treatments, such as noninvasive positive pressure ventilation (NPPV), which uses mild air pressure to keep your airways open while you sleep. Another treatment is a special bed that rocks back and forth, to help you breathe in and out. Fluids, often through an intravenous (IV), to improve blood flow throughout your body. They also provide nutrition. Medicines for discomfort Treatments for the cause of the respiratory failure. These treatments may include medicines and procedures. If you have respiratory failure, see your health care provider for ongoing medical care. Your provider may suggest pulmonary rehabilitation. If your respiratory failure is chronic, make sure that you know when and where to get help for your symptoms. You need emergency care if you have severe symptoms, such as trouble catching your breath or talking. You should call your provider if you notice that your symptoms are worsening or if you have new signs and symptoms. Living with respiratory failure may cause fear, anxiety, depression, and stress. Talk therapy, medicines, and support groups can help you feel better. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Respiratory Failure, also known as acute respiratory failure, is related to neonatal respiratory failure and adult respiratory distress syndrome, and has symptoms including dyspnea, edema and respiratory distress. An important gene associated with Respiratory Failure is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and Surfactant metabolism. The drugs Riluzole and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are no effect and homeostasis/metabolism

Disease Ontology : 12 A lung disease characterized by inadequate gas exchange by the respiratory system.

PubMed Health : 63 About respiratory failure: Respiratory (RES-pih-rah-tor-e) failure is a condition in which not enough oxygen passes from your lungs into your blood. Your body's organs, such as your heart and brain, need oxygen-rich blood to work well. Respiratory failure also can occur if your lungs can't properly remove carbon dioxide (a waste gas) from your blood. Too much carbon dioxide in your blood can harm your body's organs. Both of these problems—a low oxygen level and a high carbon dioxide level in the blood—can occur at the same time. Diseases and conditions that affect your breathing can cause respiratory failure. Examples include COPD (chronic obstructive pulmonary disease) and spinal cord injuries. COPD prevents enough air from flowing in and out of the airways. Spinal cord injuries can damage the nerves that control breathing.

Wikipedia : 75 Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the... more...

Related Diseases for Respiratory Failure

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1572)
# Related Disease Score Top Affiliating Genes
1 neonatal respiratory failure 34.9 SFTPC SFTPB ABCA3
2 adult respiratory distress syndrome 33.5 SFTPC SFTPB ELANE
3 surfactant dysfunction 32.8 SFTPC SFTPB ABCA3
4 acute respiratory distress syndrome 32.7 SFTPD SFTPC SFTPB ELANE
5 status asthmaticus 32.2 PIK3C2A ELANE
6 bronchopulmonary dysplasia 31.9 SFTPB SCGB1A1 ELANE
7 pulmonary fibrosis, idiopathic 31.9 SFTPD SFTPC SFTPB SCGB1A1 ELANE ABCA3
8 diaphragmatic hernia, congenital 31.8 SFTPC SFTPB NKX2-1
9 lung disease 31.8 SFTPD SFTPC SFTPB PDE4A NKX2-1 ELANE
10 neuromuscular disease 31.6 TTN GAA DCTN1
11 newborn respiratory distress syndrome 31.4 TTN SFTPD SFTPC SFTPB SCGB1A1 IGHMBP2
12 pulmonary disease, chronic obstructive 31.4 SFTPD SFTPB SCGB1A1 PDE4A ELANE
13 meconium aspiration syndrome 31.2 SFTPB SCGB1A1
14 pasteurellosis 31.2 ELANE ALB
15 idiopathic interstitial pneumonia 31.1 SFTPD SFTPC ELANE
16 bacterial pneumonia 31.0 SFTPD SFTPB ELANE
17 cardiac arrest 31.0 PIK3C2A ELANE ALB
18 respiratory distress syndrome in premature infants 30.8 SFTPC SFTPB NKX2-1 ABCA3
19 lung cancer susceptibility 3 30.8 SFTPC SFTPB SCGB1A1 NKX2-1
20 pulmonary emphysema 30.7 SFTPD SFTPC ELANE
21 pulmonary alveolar proteinosis 30.7 SFTPD SFTPC SFTPB
22 lung benign neoplasm 30.7 SFTPB SCGB1A1 NKX2-1
24 paraquat lung 30.6 SFTPB SCGB1A1
25 capillary leak syndrome 30.6 ELANE ALB
26 interstitial lung disease 30.6 SFTPD SFTPC SFTPB NKX2-1 ABCA3
27 tracheal agenesis 30.5 SFTPD SFTPB
28 proteasome-associated autoinflammatory syndrome 1 30.5 PDE4A ELANE ALB
29 tick paralysis 30.1 SLC4A1 PIK3C2A
30 asphyxia neonatorum 30.1 TTN PIK3C2A
31 pulmonary immaturity 29.9 SFTPD SFTPC SFTPB
32 creatine phosphokinase, elevated serum 29.5 PIK3C2A GAA
33 respiratory system disease 29.5 SFTPD SFTPC PDE4A NKX2-1 ELANE ALB
34 muscular disease 29.4 TTN PIK3C2A IGHMBP2 GAA
35 anuria 29.2 PIK3C2A ALB
36 myopathy, myofibrillar, 9, with early respiratory failure 12.9
37 hereditary proximal myopathy with early respiratory failure 12.6
38 spinal muscular atrophy, distal, autosomal recessive, 1 12.3
39 rare genetic respiratory disease 12.1
40 rare allergic respiratory disease 12.1
41 muscular dystrophy, congenital, davignon-chauveau type 11.7
42 central hypoventilation syndrome, congenital 11.6
43 amyotrophic lateral sclerosis 1 11.6
44 leigh syndrome 11.5
45 perry syndrome 11.5
46 combined oxidative phosphorylation deficiency 3 11.4
47 pulmonary edema 11.4
48 spinal muscular atrophy 11.4
49 glycogen storage disease ii 11.4
50 acute interstitial pneumonia 11.4

Comorbidity relations with Respiratory Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 113)

Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alcoholic Cardiomyopathy
Alcoholic Liver Cirrhosis Anthracosis
Anxiety Aortic Aneurysm
Aortic Valve Disease 1 Asbestosis
Aspergillosis Asthma
Bleeding Disorder, Platelet-Type, 11 Bronchiectasis
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Chronic Pulmonary Heart Disease
Conjunctivitis Conn's Syndrome
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Diaphragm Disease Disseminated Intravascular Coagulation
Dysthymic Disorder Encephalopathy
Esophageal Candidiasis Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Goodpasture Syndrome Guillain-Barre Syndrome, Familial
Heart Disease Hepatic Encephalopathy
Hypertension, Essential Hypertensive Encephalopathy
Hypertrophic Cardiomyopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma

Graphical network of the top 20 diseases related to Respiratory Failure:

Diseases related to Respiratory Failure

Symptoms & Phenotypes for Respiratory Failure

UMLS symptoms related to Respiratory Failure:

dyspnea, edema, respiratory distress, apnea, hemoptysis, cyanosis, stridor, snoring, wheezing, rhinorrhea, inspiratory stridor, sore throat, cheyne-stokes respiration, coughing, hoarseness, anoxemia, labored breathing, sneezing, expiratory wheeze, inspiratory wheeze, choking sensation, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, pleuritic pain, sinus congestion, other symptoms involving respiratory system and chest, bronchorrhea, neonatal cyanosis, gasping for breath, symptoms involving respiratory system and other chest symptoms, nasal congestion (finding), nasal irritation, neck tightness, larynx pain

GenomeRNAi Phenotypes related to Respiratory Failure according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCA3 ALB CHAT DCTN1 ELANE GAA

MGI Mouse Phenotypes related to Respiratory Failure:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ABCA3 ALB CHAT DCTN1 ELANE GAA
2 mortality/aging MP:0010768 10.28 ABCA3 ALB CHAT DCTN1 ELANE IGHMBP2
3 cardiovascular system MP:0005385 10.22 ABCA3 CHAT GAA IGHMBP2 NKX2-1 PDE4A
4 growth/size/body region MP:0005378 10.21 CHAT GAA IGHMBP2 INPP5E NKX2-1 PIK3C2A
5 cellular MP:0005384 10.2 ALB DCTN1 GAA IGHMBP2 INPP5E NKX2-1
6 behavior/neurological MP:0005386 10.19 ABCA3 CHAT DCTN1 GAA IGHMBP2 NKX2-1
7 immune system MP:0005387 10.11 DCTN1 ELANE PDE4A PIK3C2A PMS2 SCGB1A1
8 muscle MP:0005369 9.86 ALB CHAT DCTN1 GAA IGHMBP2 SLC4A1
9 neoplasm MP:0002006 9.7 ALB ELANE NKX2-1 PMS2 SCGB1A1 SFTPC
10 renal/urinary system MP:0005367 9.5 ABCA3 ALB INPP5E PIK3C2A SCGB1A1 SLC4A1
11 respiratory system MP:0005388 9.23 ABCA3 CHAT IGHMBP2 NKX2-1 SCGB1A1 SFTPB

Drugs & Therapeutics for Respiratory Failure

PubMed Health treatment related to Respiratory Failure: 63

Treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and its severity. Treatment also depends on the condition's underlying cause. Acute respiratory failure can be a medical emergency. It often is treated in an intensive care unit at a hospital. Chronic respiratory failure often can be treated at home. If chronic respiratory failure is severe, your doctor may recommend treatment in a long-term care center. One of the main goals of treating respiratory failure is to get oxygen to your lungs and other organs and remove carbon dioxide from your body. Another goal is to treat the underlying cause of the condition.

Drugs for Respiratory Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 623)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Racepinephrine Approved Phase 4 329-65-7 838
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
Clonidine Approved Phase 4 4205-90-7 2803
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
Bromhexine Approved Phase 4 3572-43-8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Ipratropium Approved, Experimental Phase 4 60205-81-4, 22254-24-6 657309 43232
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Citalopram Approved Phase 4 59729-33-8 2771
Adenosine Approved, Investigational Phase 4 58-61-7 60961
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
Ciclesonide Approved, Investigational Phase 4 126544-47-6, 141845-82-1 444033
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
Avibactam Approved Phase 4 1192500-31-4
Orphenadrine Approved Phase 4 83-98-7 4601
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
Cisatracurium Approved Phase 4 96946-41-7
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Meperidine Approved Phase 4 57-42-1 4058
Sucralfate Approved Phase 4 54182-58-0
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
Tazobactam Approved Phase 4 89786-04-9 123630
Piperacillin Approved Phase 4 66258-76-2 43672
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Loxapine Approved Phase 4 1977-10-2 3964
Nicotine Approved Phase 4 54-11-5 942 89594
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
Velpatasvir Approved, Investigational Phase 4 1377049-84-7 67683363

Interventional clinical trials:

(show top 50) (show all 2458)
# Name Status NCT ID Phase Drugs
1 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
2 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
3 A Pilot Study: Comparing Physiological Parameters and Outcome Variables Using Pressure Support Ventilation Versus Pressure Controlled Ventilation in Patients With Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
4 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
5 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
6 Role of Non-invasive Ventilation in Amyotrophic Lateral Sclerosis: Volume Versus Pressure Mode Unknown status NCT00560287 Phase 4
7 Randomized Controlled Trial of Inspiratory Muscle Training in Patients With Stable Hypercapnic Respiratory Failure Due to COPD Unknown status NCT00291460 Phase 4
8 Phase 4, Single Centre, Single Blinded,Prospective Randomised Cross Over Comparison on the Physiological Response of Post Extubation Intensive Care Patients to Non-invasive Ventilation Using Either Air O2 or Heliox21 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
10 Comparison of Different Methodologies Assessing Airway Responsiveness and Investigation of Treatment Efficacy of Budesonide /Formoterol in Asthmatics Unknown status NCT02574975 Phase 4 methacholine;adenosine monophosphate;leukotriene D4;budesonide /formoterol
11 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
12 Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial Unknown status NCT01319643 Phase 4 Oxygen
13 CPAP Application at Delivery Room at Very Low Birth Weight Infants Unknown status NCT01024361 Phase 4
14 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
15 Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections. Can Measurement of Procalcitonin Reduce the Use of Antibiotics? Unknown status NCT02171338 Phase 4
16 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Chronic Obstructive Pulmonary Disease Phenotype Unknown status NCT01431625 Phase 4
17 Acupuncture for Sedation in the Intensive Care Unit Unknown status NCT01362270 Phase 4
18 A Randomized Controlled Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
20 Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia Unknown status NCT01703130 Phase 4
21 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
22 Phase IV Study of Perioperative Steroid's Effects on Death or MI in High-Risk Patients Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass Unknown status NCT00427388 Phase 4 Methylprednisolone
23 Continuous Positive Airway Pressure for Treatment of Postoperative Hypoxemia in Liver Transplant Unknown status NCT00510770 Phase 4
24 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
25 Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis Unknown status NCT01216553 Phase 4
26 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
27 A Randomized Trial to Compare the Effectiveness of Hospital or Ambulatory Approach for Adaptation to Non-Invasive Mechanical Ventilation in Patients With Chronic Respiratory Failure Secondary to Neuromuscular Diseases or Thoracic Cage Alterations Completed NCT00698958 Phase 4
28 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
29 Non-Positive Pressure Ventilation in Hypoxemic Patients. A Randomized Study Completed NCT00925860 Phase 4
30 Hypercapnic Acute Respiratory Failure: Is the Helmet an Effective Interface?" Completed NCT01645358 Phase 4
31 Effects of Remifentanil on Breathing Pattern, Respiratory Effort and Gas Exchange in Mechanically Ventilated Patients. Completed NCT00665119 Phase 4 remifentanil;placebo
32 High-assistance Proportional Assist Ventilation (PAV) vs. Assist-Control Ventilation (ACV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
33 Patients-ventilator Interaction During Sleep: the Role of Humidification. A Pilot Short Term Study Completed NCT01038791 Phase 4
34 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of YMC026 in Respiratory Disease Patients With Cough and Sputum as the Main Symptoms Completed NCT03334916 Phase 4 YMC026;Placebo
35 The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases Completed NCT01867281 Phase 4 aspirin
36 Does a Diagnostic Strategy Reduce Duration and Cost of Hospitalization in Patients With Acute Dyspnea? BASEL II Intensive Care Unit Completed NCT00130559 Phase 4
37 A Randomized Controlled Trial Comparing Two Protocols to Withdraw Non-invasive Ventilation (NIV) After an Episode of Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
38 Study to Evaluate the Effect of Roflumilast 500 μg on Exacerbation Rate in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Treated With a Fixed-Dose Combination of Long-Acting Beta Agonist and Inhaled Corticosteroid (LABA/ICS) Completed NCT01443845 Phase 4 Roflumilast;Placebo
39 Multicenter, Randomised Study of the Use of Non-Invasive Ventilation (NIV) Versus Oxygen Therapy (O2) in Reducing Dyspnea in End-stage Solid Cancer Patients With Respiratory Failure and Distress Completed NCT00533143 Phase 4
40 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
41 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation. Randomized Clinical Trial Completed NCT02526862 Phase 4
42 Early Application of CPAP in Hematologic Neutropenic Patients Avoid Acute Respiratory Failure Completed NCT00507533 Phase 4
43 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation: The PrePARE Trial Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
44 Recruitment Maneuver Increases Oxygenation After Intubation in Hypoxemic ICU Patients: a Randomized Controlled Study Completed NCT01014299 Phase 4
45 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
46 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
47 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
48 Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial Completed NCT01472302 Phase 4
49 Effect of Neuromuscular Blockade and Reversal by Sugammadex Versus Neostigmine on Breathing When Hypoxic or Hypercapnic in Volunteers Completed NCT02845375 Phase 4 Sugammadex;Neostigmine;Placebo
50 The Effect of Supplemental Oxygen During Physical Exercise Training on Exercise Capacity in COPD Patients. Completed NCT01150383 Phase 4

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS 72 / NDF-RT 51 :

Nalmefene hydrochloride
Naloxone Hydrochloride
Nitric Oxide
prednisolone acetate
Prednisolone sodium phosphate
prednisolone tebutate

Genetic Tests for Respiratory Failure

Genetic tests related to Respiratory Failure:

# Genetic test Affiliating Genes
1 Respiratory Insufficiency 29
2 Respiratory Failure 29

Anatomical Context for Respiratory Failure

MalaCards organs/tissues related to Respiratory Failure:

Lung, Heart, Testes, Brain, Liver, Bone, Kidney

Publications for Respiratory Failure

Articles related to Respiratory Failure:

(show top 50) (show all 28619)
# Title Authors PMID Year
Mechanical Ventilation in Hypoxemic Respiratory Failure. 38 17
31262413 2019
Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: a pragmatic, randomised controlled trial. 17
31227374 2019
Septoplasty-a surgical or political challenge? 17
31227372 2019
Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. 9 38
19824815 2010
Inherited surfactant deficiency caused by uniparental disomy of rare mutations in the surfactant protein-B and ATP binding cassette, subfamily a, member 3 genes. 9 38
19647838 2009
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model. 9 38
19539245 2009
Interfamilial phenotypic heterogeneity in SMARD1. 9 38
19157874 2009
Association of polymorphisms in the human surfactant protein-D (SFTPD) gene and postnatal pulmonary adaptation in the preterm infant. 9 38
18785967 2009
[Lung diseases associated with inherited disorders of surfactant metabolism]. 9 38
18804975 2008
Surfactant protein B deficiency caused by a novel mutation involving multiple exons of the SP-B gene. 9 38
18558554 2008
Clinical and mutational profile in spinal muscular atrophy with respiratory distress (SMARD): defining novel phenotypes through hierarchical cluster analysis. 9 38
17431882 2007
Adult glycogenosis type II (Pompe's disease): morphological abnormalities in muscle and skin biopsies compared with acid alpha-glucosidase activity. 9 38
18176891 2007
Lung specific developmental expression of the Xenopus laevis surfactant protein C and B genes. 9 38
16798105 2007
Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: clinical features and evaluation. 9 38
17142157 2006
Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. 9 38
16763223 2006
Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. 9 38
17011330 2006
Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. 9 38
16912630 2006
Surfactant protein B deficiency: a rare cause of respiratory failure in a Lebanese newborn. 9 38
16521884 2006
Reversibility of lung inflammation caused by SP-B deficiency. 9 38
16024721 2005
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 9 38
16005263 2005
Interstitial lung disease in children -- genetic background and associated phenotypes. 9 38
15819986 2005
[Neonatal respiratory failure associated with mutation in the surfactant protein C gene]. 9 38
15737281 2005
Actin mutations are one cause of congenital fibre type disproportion. 9 38
15468086 2004
C-reactive protein and body mass index predict outcome in end-stage respiratory failure. 9 38
15302742 2004
[Surfactant-associated proteins B and C: molecular biology and physiologic properties]. 9 38
15229816 2004
Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. 9 38
15190959 2004
Allelic heterogeneity of SMARD1 at the IGHMBP2 locus. 9 38
15108294 2004
Surfactant protein B deficiency in infants with respiratory failure. 9 38
15027668 2004
Severe infantile neuropathy with diaphragmatic weakness and its relationship to SMARD1. 9 38
14506069 2003
Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. 9 38
13129928 2003
[Respiratory diseases associated to surfactant proteins B and C deficiency]. 9 38
15279365 2003
Genetic influences and neonatal lung disease. 9 38
12667827 2003
Article reviewed: Sleep-disordered breathing and respiratory failure in acid maltase deficiency. 9 38
14592241 2002
Sleep-disordered breathing and respiratory failure in acid maltase deficiency. 9 38
11591850 2001
Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure. 9 38
11520731 2001
CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. 9 38
10934091 2000
Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure. 9 38
10931427 2000
Pulmonary surfactant metabolism in infants lacking surfactant protein B. 9 38
10696076 2000
Hereditary surfactant protein B deficiency resulting from a novel mutation. 9 38
10663288 2000
Recurrent familial neonatal deaths: hereditary surfactant protein B deficiency. 9 38
11041444 2000
Inhibition of lung surfactant protein B expression during Pneumocystis carinii pneumonia in mice. 9 38
10235125 1999
Surfactant protein B deficiency: clinical, histological and molecular evaluation. 9 38
10365365 1999
Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency. 9 38
10571948 1999
Clearance of Clara cell secretory protein 16 (CC16) and surfactant proteins A and B from blood in acute respiratory failure. 9 38
9817704 1998
A 60-year-old woman with weakness, fatigue, and acute respiratory failure: case report and discussion of the differential diagnosis. 9 38
9795552 1998
Regulation and function of pulmonary surfactant protein B. 9 38
9758711 1998
Deletion of thyroid transcription factor-1 gene in an infant with neonatal thyroid dysfunction and respiratory failure. 9 38
9565498 1998
Transient surfactant protein B deficiency in a term infant with severe respiratory failure. 9 38
9506635 1998
An early onset muscular dystrophy with diaphragmatic involvement, early respiratory failure and secondary alpha2 laminin deficiency unlinked to the LAMA2 locus on 6q22. 9 38
10726842 1998
[Chronic respiratory failure in a case with juvenile-onset acid alpha-glucosidase deficiency; successful therapy with nasal intermittent positive pressure ventilation (NIPPV)]. 9 38
8986097 1997

Variations for Respiratory Failure

ClinVar genetic disease variations for Respiratory Failure:

6 (show all 13)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 10:50872926-50872926 10:49664880-49664880
2 PMS2 NM_000535.7(PMS2): c.1927C> T (p.Gln643Ter) single nucleotide variant Pathogenic rs63751422 7:6026469-6026469 7:5986838-5986838
3 INPP5E NM_019892.6(INPP5E): c.1132C> T (p.Arg378Cys) single nucleotide variant Pathogenic/Likely pathogenic rs121918130 9:139327634-139327634 9:136433182-136433182
4 ABCA3 NM_001089.3(ABCA3): c.875A> T (p.Glu292Val) single nucleotide variant Pathogenic/Likely pathogenic rs149989682 16:2367764-2367764 16:2317763-2317763
5 MUSK NM_005592.4(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Likely pathogenic rs751889864 9:113547944-113547944 9:110785664-110785664
6 TNFRSF13B NM_012452.2(TNFRSF13B): c.310T> C (p.Cys104Arg) single nucleotide variant risk factor rs34557412 17:16852187-16852187 17:16948873-16948873
7 MUSK NM_005592.4(MUSK): c.2365G> A (p.Gly789Ser) single nucleotide variant Likely pathogenic rs1057518966 9:113563023-113563023 9:110800743-110800743
8 RYR1 NM_000540.2(RYR1): c.1186G> A (p.Glu396Lys) single nucleotide variant Likely pathogenic rs774919231 19:38942467-38942467 19:38451827-38451827
9 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 10:50835781-50835781 10:49627735-49627735
10 RYR1 NM_000540.2(RYR1): c.844C> T (p.Arg282Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs1057518970 19:38939038-38939038 19:38448398-38448398
11 VANGL1 NM_138959.3(VANGL1): c.523C> T (p.Arg175Trp) single nucleotide variant Uncertain significance rs142594314 1:116206600-116206600 1:115663979-115663979
12 GATA4 NM_002052.5(GATA4): c.94G> C (p.Ala32Pro) single nucleotide variant Uncertain significance 8:11565915-11565915 8:11708406-11708406
13 ERF NM_006494.4(ERF): c.1636C> T (p.Arg546Ter) single nucleotide variant Uncertain significance 19:42752628-42752628 19:42248476-42248476

Expression for Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for Respiratory Failure

Pathways related to Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
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GO Terms for Respiratory Failure

Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellar body GO:0042599 9.26 SFTPC SFTPB
2 multivesicular body lumen GO:0097486 9.16 SFTPC SFTPB
3 alveolar lamellar body GO:0097208 8.96 SFTPB ABCA3
4 clathrin-coated endocytic vesicle GO:0045334 8.8 SFTPD SFTPC SFTPB

Biological processes related to Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 striated muscle contraction GO:0006941 9.16 TTN GAA
2 respiratory gaseous exchange GO:0007585 9.13 SFTPD SFTPC SFTPB
3 cellular protein metabolic process GO:0044267 9.02 SFTPD SFTPC SFTPB ALB ABCA3

Sources for Respiratory Failure

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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