MCID: RSP002
MIFTS: 58

Respiratory Syncytial Virus Infectious Disease

Categories: Infectious diseases

Aliases & Classifications for Respiratory Syncytial Virus Infectious Disease

MalaCards integrated aliases for Respiratory Syncytial Virus Infectious Disease:

Name: Respiratory Syncytial Virus Infectious Disease 12
Respiratory Syncytial Virus Infections 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1273
MeSH 44 D018357
NCIt 50 C3354
SNOMED-CT 68 55735004
UMLS 73 C0035235

Summaries for Respiratory Syncytial Virus Infectious Disease

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Respiratory Syncytial Virus Infectious Disease, also known as respiratory syncytial virus infections, is related to viral infectious disease and pulmonary eosinophilia, and has symptoms including fever, respiratory distress and cough. An important gene associated with Respiratory Syncytial Virus Infectious Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs RespiGam and Synagis have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and testes, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in upper respiratory tract or located in lower respiratory tract, has material basis in Human respiratory syncytial virus, which is transmitted by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted by contaminated fomites. The infection has symptom runny nose, has symptom fever, has symptom cough, has symptom wheezing, and has symptom respiratory distress.

Related Diseases for Respiratory Syncytial Virus Infectious Disease

Diseases related to Respiratory Syncytial Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 31.3 CCL3 CCL5 IFNB1 IRF1
2 pulmonary eosinophilia 30.6 CCL5 IL13 IL5
3 asthma 30.5 CCL3 CCL5 IL13 IL5
4 bronchiolitis 30.4 CCL3 CCL5 IL13 IL5
5 respiratory allergy 30.1 IL13 IL5
6 allergic asthma 30.1 CCL5 IL13 IL5
7 pneumonia 29.9 CCL3 CCL5 IL13 IL5 SFTPB
8 parainfluenza virus type 3 29.9 IFNB1 NEU1
9 lung disease 29.8 CCL3 CCL5 IL13 IL5 SFTPB
10 influenza 10.5
11 cystic fibrosis 10.3
12 bronchiolitis obliterans 10.2
13 bronchopulmonary dysplasia 10.2
14 heart disease 10.2
15 conjunctivitis 10.2 IL13 IL5
16 keratoconjunctivitis 10.2 IL13 IL5
17 cytokine deficiency 10.2 IL13 IL5
18 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
19 nickel allergic contact dermatitis 10.2 IL13 IL5
20 paragonimiasis 10.2 IL13 IL5
21 status asthmaticus 10.2 CCL5 IL5
22 chronic eosinophilic pneumonia 10.2 CCL5 IL5
23 angiostrongyliasis 10.2 IL13 IL5
24 inflammatory bowel disease 4 10.2 IL13 IL5
25 apple allergy 10.2 IL13 IL5
26 strongyloidiasis 10.2 IL13 IL5
27 ascaris lumbricoides infection 10.2 IL13 IL5
28 kimura disease 10.2 CCL5 IL5
29 latex allergy 10.2 IL13 IL5
30 african tick-bite fever 10.2 CCL5 IL13
31 eosinophilic meningitis 10.2 IL13 IL5
32 intestinal schistosomiasis 10.2 IL13 IL5
33 folliculitis 10.2 CCL5 IL5
34 chronic tic disorder 10.2 IL13 IL5
35 eosinophilic gastritis 10.2 IL13 IL5
36 radiculopathy 10.2 CCL5 IL5
37 urinary schistosomiasis 10.2 IL13 IL5
38 inclusion conjunctivitis 10.2 CCL5 IL5
39 esophagitis, eosinophilic, 1 10.1 IL13 IL5
40 esophagitis 10.1 IL13 IL5
41 pneumothorax, primary spontaneous 10.1
42 down syndrome 10.1
43 pneumothorax 10.1
44 encephalopathy 10.1
45 pollen allergy 10.1 IL13 IL5
46 enterobiasis 10.1 IL13 IL5
47 bullous skin disease 10.1 CCL5 IL5
48 conjunctival disease 10.1 IL13 IL5
49 necatoriasis 10.1 CCL3 IL5
50 whiplash 10.1 CCL3 CCL5

Graphical network of the top 20 diseases related to Respiratory Syncytial Virus Infectious Disease:



Diseases related to Respiratory Syncytial Virus Infectious Disease

Symptoms & Phenotypes for Respiratory Syncytial Virus Infectious Disease

Symptoms:

12
  • fever
  • respiratory distress
  • cough
  • wheezing
  • runny nose

UMLS symptoms related to Respiratory Syncytial Virus Infectious Disease:


fever, pruritus, snoring, coughing

MGI Mouse Phenotypes related to Respiratory Syncytial Virus Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCL5 IFNB1 IL13 IL5 IRF1 NEU1
2 immune system MP:0005387 9.1 CCL5 IFNB1 IL13 IL5 IRF1 NEU1

Drugs & Therapeutics for Respiratory Syncytial Virus Infectious Disease

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
RespiGam 18 MedImmune January 1996
2
Synagis 18 PALIVIZUMAB MedImmune June 1998

Search Clinical Trials , NIH Clinical Center for Respiratory Syncytial Virus Infectious Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: respiratory syncytial virus infections

Genetic Tests for Respiratory Syncytial Virus Infectious Disease

Anatomical Context for Respiratory Syncytial Virus Infectious Disease

MalaCards organs/tissues related to Respiratory Syncytial Virus Infectious Disease:

41
Lung, Neutrophil, Testes, Bone, Heart, Bone Marrow, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory Syncytial Virus Infectious Disease:

19
Upper Respiratory Tract Or

Publications for Respiratory Syncytial Virus Infectious Disease

Articles related to Respiratory Syncytial Virus Infectious Disease:

(show top 50) (show all 246)
# Title Authors Year
1
Case study-based time-course analysis of symptoms of respiratory syncytial virus infections followed by acute sinusitis in otherwise-healthy adults. ( 29997985 )
2018
2
Cost-effectiveness of rule-based immunoprophylaxis against respiratory syncytial virus infections in preterm infants. ( 29168012 )
2018
3
Dose-dependent relationships between weight status and clinical outcomes among infants hospitalized with respiratory syncytial virus infections. ( 29359458 )
2018
4
Comparative effectiveness of aerosolized versus oral ribavirin for the treatment of respiratory syncytial virus infections: A single-center retrospective cohort study and review of the literature. ( 29360277 )
2018
5
Safety of Palivizumab Stewardship in Conjunction with Infection Prevention and Control Strategies for Healthcare-Associated Respiratory Syncytial Virus Infections. ( 29463335 )
2018
6
Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children. ( 29742646 )
2018
7
Seasonal peaks and risk factors of respiratory syncytial virus infections related hospitalization of preterm infants in Taiwan. ( 29746578 )
2018
8
Respiratory syncytial virüs infections in neonates and infants. ( 30116126 )
2018
9
Oral versus Aerosolized Ribavirin for the Treatment of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplantation Recipients. ( 30202920 )
2018
10
Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico. ( 27439650 )
2017
11
The Outpatient Burden of Respiratory Syncytial Virus Infections in Older Children. ( 27738053 )
2017
12
Statistical Power to Detect an Association Between Guideline-based Palivizumab Administration and Hospitalizations for Respiratory Syncytial Virus Infections. ( 28187116 )
2017
13
In Reply: Statistical Power to Detect an Association Between Guideline-based Palivizumab Administration and Hospitalizations for Respiratory Syncytial Virus Infections. ( 28187117 )
2017
14
Effect of climate on incidence of respiratory syncytial virus infections in a refugee camp in Kenya: A non-Gaussian time-series analysis. ( 28570627 )
2017
15
The Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Norwegian Children. ( 28838133 )
2017
16
Palivizumab for prophylaxis of respiratory syncytial virus infections in preterm neonates. ( 28926860 )
2017
17
A Two-Dimensional Human Minilung System (Model) for Respiratory Syncytial Virus Infections. ( 29232863 )
2017
18
Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections. ( 26658377 )
2016
19
Cytokine responses in primary and secondary respiratory syncytial virus infections. ( 26882371 )
2016
20
Association Between Updated Guideline-Based Palivizumab Administration and Hospitalizations for Respiratory Syncytial Virus Infections. ( 27078122 )
2016
21
Development of Acquired Immunity following Repeated Respiratory Syncytial Virus Infections in Cotton Rats. ( 27224021 )
2016
22
Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts. ( 27314379 )
2016
23
Detection of bovine respiratory syncytial virus infections in young dairy and beef cattle in Poland. ( 25365424 )
2015
24
An attraction-repulsion point process model for respiratory syncytial virus infections. ( 25660222 )
2015
25
Chemotherapy of respiratory syncytial virus infections: the final breakthrough. ( 25684638 )
2015
26
Frequent Asymptomatic Respiratory Syncytial Virus Infections During an Epidemic in a Rural Kenyan Household Cohort. ( 25941331 )
2015
27
Incidence, risk factors and hospital burden in children under five years of age hospitalised with respiratory syncytial virus infections. ( 26036725 )
2015
28
Trends of Respiratory Syncytial Virus Infections in Children under 2 Years of Age in Puerto Rico. ( 26061061 )
2015
29
Respiratory syncytial virus infections in pediatric transplant recipients: A Canadian Paediatric Surveillance Program study. ( 26152857 )
2015
30
Potential Treatment for the Respiratory Syncytial Virus Infections (HRSV). ( 26191357 )
2015
31
Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections. ( 26268314 )
2015
32
Clinical utility of a near patient care microarray based diagnostic test for influenza and respiratory syncytial virus infections. ( 26629177 )
2015
33
Burden of respiratory syncytial virus infections in China: Systematic review and meta-analysis. ( 26682049 )
2015
34
Novel clinical features of recurrent human respiratory syncytial virus infections. ( 24166209 )
2014
35
Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity. ( 24227634 )
2014
36
Medically attended respiratory syncytial virus infections in adults aged ≥ 50 years: clinical characteristics and outcomes. ( 24265361 )
2014
37
Epidemiology and risk factors for severe respiratory syncytial virus infections requiring pediatric intensive care admission in Hong Kong children. ( 24277597 )
2014
38
Respiratory syncytial virus infections in children with cancer. ( 24327130 )
2014
39
The clinical utility of a near patient care rapid microarray-based diagnostic test for influenza and respiratory syncytial virus infections in the pediatric setting. ( 24582577 )
2014
40
Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice. ( 24587397 )
2014
41
Oral ribavirin therapy for respiratory syncytial virus infections in moderately to severely immunocompromised patients. ( 24621016 )
2014
42
Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice. ( 24906563 )
2014
43
Respiratory syncytial virus infections in infants affected by primary immunodeficiency. ( 25089282 )
2014
44
Nosocomial respiratory syncytial virus infections in the palivizumab-prophylaxis era with implications regarding high-risk infants. ( 25179332 )
2014
45
Is palivizumab effective as a prophylaxis of respiratory syncytial virus infections in cystic fibrosis patients? A meta-analysis. ( 24231153 )
2013
46
Incidence and clinical features of respiratory syncytial virus infections in a population-based surveillance site in the Nile Delta Region. ( 24265478 )
2013
47
Outbreak of respiratory syncytial virus infections in a nursing home and possible sources of introduction: the Netherlands, winter 2012/2013. ( 24329823 )
2013
48
A model of the costs of community and nosocomial pediatric respiratory syncytial virus infections in Canadian hospitals. ( 24421788 )
2013
49
Respiratory syncytial virus infections in infants and children with congenital heart disease: update on the evidence of prevention with palivizumab. ( 23337892 )
2013
50
The epidemiology and clinical characteristics of young children hospitalized with respiratory syncytial virus infections in Guatemala (2007-2010). ( 23380666 )
2013

Variations for Respiratory Syncytial Virus Infectious Disease

Expression for Respiratory Syncytial Virus Infectious Disease

LifeMap Discovery
Genes differentially expressed in tissues of Respiratory Syncytial Virus Infectious Disease patients vs. healthy controls: 35 (show all 44)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 IFI27 interferon, alpha-inducible protein 27 Blood + 6.10 0.000
2 OLFM4 olfactomedin 4 Blood + 5.54 0.000
3 PRTN3 proteinase 3 Blood + 5.47 0.000
4 CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) Blood + 5.04 0.000
5 MMP8 matrix metallopeptidase 8 Blood + 4.32 0.000
6 MPO myeloperoxidase Blood + 4.23 0.000
7 HP haptoglobin Blood + 4.21 0.000
8 CTSG cathepsin G Blood + 4.10 0.000
9 DEFA4 defensin, alpha 4, corticostatin Blood + 3.98 0.000
10 OTOF otoferlin Blood + 3.94 0.000
11 OLFM1 olfactomedin 1 Blood - 3.93 0.000
12 RETN resistin Blood + 3.90 0.000
13 ARG1 arginase 1 Blood + 3.89 0.000
14 GPR84 G protein-coupled receptor 84 Blood + 3.88 0.000
15 NOV nephroblastoma overexpressed Blood - 3.79 0.000
16 ELANE elastase, neutrophil expressed Blood + 3.76 0.000
17 RHAG Rh-associated glycoprotein Blood + 3.73 0.000
18 CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial Blood + 3.68 0.000
19 MAOA monoamine oxidase A Blood + 3.62 0.000
20 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 3.62 0.000
21 CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 Blood + 3.55 0.000
22 KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 Blood - 3.48 0.000
23 HBBP1 hemoglobin, beta pseudogene 1 Blood + 3.45 0.000
24 AZU1 azurocidin 1 Blood + 3.43 0.000
25 ANXA3 annexin A3 Blood + 3.42 0.000
26 COL17A1 collagen, type XVII, alpha 1 Blood + 3.39 0.000
27 CD177 CD177 molecule Blood + 3.38 0.000
28 PRSS33 protease, serine, 33 Blood - 3.36 0.000
29 METTL7B methyltransferase like 7B Blood + 3.33 0.000
30 GPR42 G protein-coupled receptor 42 (gene/pseudogene) Blood + 3.27 0.000
31 C1QC complement component 1, q subcomponent, C chain Blood + 3.24 0.000
32 KCTD14 potassium channel tetramerization domain containing 14 Blood + 3.22 0.000
33 DEFA3 defensin, alpha 3, neutrophil-specific Blood + 3.20 0.000
34 FGF9 fibroblast growth factor 9 Blood - 3.15 0.000
35 PTGDR2 prostaglandin D2 receptor 2 Blood - 3.15 0.000
36 RSAD2 radical S-adenosyl methionine domain containing 2 Blood + 3.13 0.000
37 ADGRE4P adhesion G protein-coupled receptor E4, pseudogene Blood - 3.11 0.000
38 MMP28 matrix metallopeptidase 28 Blood - 3.09 0.000
39 XK X-linked Kx blood group Blood + 3.08 0.000
40 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa Blood + 3.04 0.000
41 KIF5C kinesin family member 5C Blood - 3.03 0.000
42 DLK1 delta-like 1 homolog (Drosophila) Blood + 3.01 0.000
43 LRRC26 leucine rich repeat containing 26 Blood - 3.01 0.000
44 LTF lactotransferrin Blood + 3.00 0.000
Search GEO for disease gene expression data for Respiratory Syncytial Virus Infectious Disease.

Pathways for Respiratory Syncytial Virus Infectious Disease

Pathways related to Respiratory Syncytial Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 CCL3 CCL5 IFNB1 IL13 IL5 IRF1
2
Show member pathways
13.21 CCL3 CCL5 IFNB1 IL13 IL5 IRF1
3
Show member pathways
12.96 CCL3 CCL5 IFNB1 IL13 IL5 IRF1
4
Show member pathways
12.14 IFNB1 IL13 IL5
5
Show member pathways
11.99 IFNB1 IL13 IL5 IRF1
6 11.74 CCL5 IFNB1 IRF1
7 11.71 CCL3 IFNB1 IRF1
8 11.55 IL13 IL5 IRF1
9 11.51 CCL3 IL13 IL5
10 11.43 CCL3 CCL5 IL13
11
Show member pathways
11.37 CCL3 CCL5 IL13 IL5 IRF1
12 11.27 IL13 IL5
13 11.19 CCL3 CCL5 IL13
14 11.16 IFNB1 IRF1
15 11.09 IL13 IL5
16 11.02 IL13 IRF1
17 10.98 IL13 IL5
18 10.94 CCL5 IFNB1
19 10.79 CCL3 CCL5 IL13 IL5
20 10.79 IFNB1 IL13 IL5
21 10.75 CCL3 CCL5 IL13 IL5
22 10.72 CCL3 CCL5 IL13 IL5

GO Terms for Respiratory Syncytial Virus Infectious Disease

Cellular components related to Respiratory Syncytial Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CCL3 CCL5 IFNB1 IL13 IL5 SFTPB
2 extracellular region GO:0005576 9.17 CCL3 CCL5 IFNB1 IL13 IL5 NEU1

Biological processes related to Respiratory Syncytial Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CCL3 CCL5 IL13 IL5
2 MAPK cascade GO:0000165 9.7 CCL3 CCL5 IL5
3 type I interferon signaling pathway GO:0060337 9.61 IFNB1 IRF1
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 CCL5 IL13
5 positive chemotaxis GO:0050918 9.59 CCL3 CCL5
6 monocyte chemotaxis GO:0002548 9.58 CCL3 CCL5
7 negative regulation of viral genome replication GO:0045071 9.58 CCL5 IFNB1
8 positive regulation of B cell proliferation GO:0030890 9.57 IL13 IL5
9 protein kinase B signaling GO:0043491 9.56 CCL3 CCL5
10 inflammatory response GO:0006954 9.56 CCL3 CCL5 IL13 IL5
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.55 CCL3 CCL5
12 lymphocyte chemotaxis GO:0048247 9.54 CCL3 CCL5
13 positive regulation of calcium ion transport GO:0051928 9.51 CCL3 CCL5
14 positive regulation of JAK-STAT cascade GO:0046427 9.49 CCL5 IL5
15 positive regulation of innate immune response GO:0045089 9.48 CCL5 IFNB1
16 eosinophil chemotaxis GO:0048245 9.46 CCL3 CCL5
17 cellular response to interferon-beta GO:0035458 9.43 IFNB1 IRF1
18 macrophage chemotaxis GO:0048246 9.37 CCL3 CCL5
19 regulation of signaling receptor activity GO:0010469 9.35 CCL3 CCL5 IFNB1 IL13 IL5
20 negative regulation by host of viral transcription GO:0043922 9.32 CCL3 CCL5
21 positive regulation of natural killer cell chemotaxis GO:2000503 9.16 CCL3 CCL5
22 cytokine-mediated signaling pathway GO:0019221 9.02 CCL3 CCL5 IFNB1 IL13 IL5

Molecular functions related to Respiratory Syncytial Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.43 CCL3 CCL5
2 chemoattractant activity GO:0042056 9.4 CCL3 CCL5
3 CCR chemokine receptor binding GO:0048020 9.37 CCL3 CCL5
4 cytokine receptor binding GO:0005126 9.32 IFNB1 IL13
5 CCR5 chemokine receptor binding GO:0031730 9.26 CCL3 CCL5
6 phospholipase activator activity GO:0016004 9.16 CCL3 CCL5
7 cytokine activity GO:0005125 9.02 CCL3 CCL5 IFNB1 IL13 IL5
8 CCR1 chemokine receptor binding GO:0031726 8.96 CCL3 CCL5

Sources for Respiratory Syncytial Virus Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....