Respiratory System Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050621

Sources

Summaries for Respiratory System Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to ureter small cell carcinoma and esophageal neuroendocrine tumor. An important gene associated with Respiratory System Benign Neoplasm is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Extracellular vesicle-mediated signaling in recipient cells and G-protein signaling_K-RAS regulation pathway. Affiliated tissues include lung, bone and spinal cord.

Sources

Related Diseases for Respiratory System Benign Neoplasm

Diseases in the Respiratory System Cancer family:

Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)

#	Related Disease	Score	Top Affiliating Genes
1	ureter small cell carcinoma	10.3	CHGA SYP
2	esophageal neuroendocrine tumor	10.3	CHGA SYP
3	lung adenoid cystic carcinoma	10.3	KRAS NKX2-1
4	ovarian large-cell neuroendocrine carcinoma	10.3	CHGA SYP
5	adenoma of the pancreas	10.3	CHGA SYP
6	acinar cell cystadenocarcinoma	10.3	CHGA SYP
7	peritoneal serous adenocarcinoma	10.2	CHGA SYP
8	cellular ependymoma	10.2	CHGA SYP
9	primary hepatic neuroendocrine carcinoma	10.2	CHGA SYP
10	ganglioneuroblastoma	10.2	ENO2 SYP
11	gastrointestinal neuroendocrine tumor	10.2	CHGA SYP
12	chordoid meningioma	10.2	CHGA SYP
13	carotid body cancer	10.2	ENO2 SYP
14	olfactory groove meningioma	10.2	CHGA SYP
15	malignant sertoli cell tumor	10.2	ENO2 SYP
16	alveoli adenoma	10.2	KRAS NKX2-1
17	sinonasal undifferentiated carcinoma	10.2	ENO2 SYP
18	pancreatic serous cystadenoma	10.2	CHGA SYP
19	conventional angiosarcoma	10.2	CHGA SYP
20	pancreatic somatostatinoma	10.2	ENO2 SYP
21	cutaneous ganglioneuroma	10.2	ENO2 SYP
22	extrahepatic bile duct adenocarcinoma	10.2	ENO2 SYP
23	papillary tumor of the pineal region	10.2	ENO2 SYP
24	sensory organ benign neoplasm	10.2	ENO2 SYP
25	orbital cancer	10.2	ENO2 SYP
26	middle ear adenoma	10.2	ENO2 SYP
27	intracranial primitive neuroectodermal tumor	10.2	CHGA ENO2
28	central nervous system primitive neuroectodermal neoplasm	10.2	ENO2 SYP
29	cerebellum cancer	10.2	ENO2 SYP
30	clear cell ependymoma	10.2	ENO2 SYP
31	cerebral neuroblastoma	10.2	ENO2 SYP
32	endometrial small cell carcinoma	10.2	ENO2 SYP
33	somatostatinoma	10.2	CHGA ENO2
34	rete testis adenocarcinoma	10.2	ENO2 NKX2-1
35	pancreatoblastoma	10.2	CHGA SYP
36	extraosseous chondrosarcoma	10.2	ENO2 SYP
37	subependymal glioma	10.2	ENO2 SYP
38	malignant teratoma	10.2	ENO2 SYP
39	epithelioid malignant peripheral nerve sheath tumor	10.2	CHGA ENO2
40	anterior cranial fossa meningioma	10.2	CHGA SYP
41	astroblastoma	10.2	ENO2 SYP
42	lung oat cell carcinoma	10.2	CHGA ENO2
43	cerebral ventricle cancer	10.2	ENO2 SYP
44	goblet cell carcinoid	10.2	CHGA ENO2
45	pineal gland cancer	10.2	ENO2 SYP
46	melanotic neuroectodermal tumor	10.2	ENO2 SYP
47	benign ependymoma	10.2	ENO2 SYP
48	acute thyroiditis	10.2	CHGA ENO2
49	rhabdoid cancer	10.2	ENO2 SYP
50	pleomorphic xanthoastrocytoma	10.2	CHGA SYP

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:

Sources

Symptoms & Phenotypes for Respiratory System Benign Neoplasm

Sources

Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

Sources

Genetic Tests for Respiratory System Benign Neoplasm

Sources

Anatomical Context for Respiratory System Benign Neoplasm

MalaCards organs/tissues related to Respiratory System Benign Neoplasm:

⁴¹

Lung, Bone, Spinal Cord, Thyroid, Testis, Pineal, Cerebellum

Sources

Publications for Respiratory System Benign Neoplasm

Sources

Genes for Respiratory System Benign Neoplasm

Genes related to Respiratory System Benign Neoplasm (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NKX2-1	NK2 Homeobox 1	Protein Coding	16.55	DISEASES inferred ¹⁵
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	15.67	DISEASES inferred ¹⁵
3	SYP	Synaptophysin	Protein Coding	15.39	DISEASES inferred ¹⁵
4	MORN1	MORN Repeat Containing 1	Protein Coding	15.36	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	15.34	DISEASES inferred ¹⁵
6	VPS16	VPS16, CORVET/HOPS Core Subunit	Protein Coding	15.26	DISEASES inferred ¹⁵
7	ENO2	Enolase 2	Protein Coding	15.25	DISEASES inferred ¹⁵
8	SLC22A23	Solute Carrier Family 22 Member 23	Protein Coding	15.11	DISEASES inferred ¹⁵
9	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	15.01	DISEASES inferred ¹⁵
10	SFTPB	Surfactant Protein B	Protein Coding	14.96	DISEASES inferred ¹⁵
11	CASC1	Cancer Susceptibility 1	Protein Coding	6.87	DISEASES inferred ¹⁵
12	LRMP	Lymphoid Restricted Membrane Protein	Protein Coding	6.74	DISEASES inferred ¹⁵
13	LMNTD1	Lamin Tail Domain Containing 1	Protein Coding	6.17	DISEASES inferred ¹⁵

Sources

Variations for Respiratory System Benign Neoplasm

Sources

Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

Sources

Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Extracellular vesicle-mediated signaling in recipient cells ¹	10.73	KRAS RAF1
2	G-protein signaling_K-RAS regulation pathway ²²	10.59	KRAS RAF1
3	CD209 (DC-SIGN) signaling ⁶⁶	10.3	KRAS RAF1
4	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	9.92	KRAS RAF1

Sources

GO Terms for Respiratory System Benign Neoplasm

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	thyroid gland development	GO:0030878	9.16	NKX2-1 RAF1
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	8.96	KRAS SYP
3	epithelial tube branching involved in lung morphogenesis	GO:0060441	8.62	KRAS NKX2-1

Sources

Sources for Respiratory System Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia