MCID: RSP004
MIFTS: 27

Respiratory System Benign Neoplasm

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0050621
ICD10 31 D14.4

Summaries for Respiratory System Benign Neoplasm

Disease Ontology: 11 An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary: Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are Disease and ESR-mediated signaling. Related phenotypes are Decreased viability and neoplasm

Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 515)
# Related Disease Score Top Affiliating Genes
1 pleural lipoma 11.2
2 trachea leiomyoma 11.2
3 nasal cavity benign neoplasm 11.2
4 common bile duct neoplasm 10.5 KRAS HRAS
5 endometrial mucinous adenocarcinoma 10.4 KRAS CDKN2A
6 tonsillar pillar cancer 10.4 EGFR CDKN2A
7 hepatic flexure cancer 10.4 KRAS HRAS
8 trachea carcinoma in situ 10.4 KRAS HRAS CDKN2A
9 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.4 TP53 CDKN2A
10 liver angiosarcoma 10.4 TP53 KRAS HRAS
11 large cell carcinoma with rhabdoid phenotype 10.4 TP53 KRAS HRAS
12 pancreatic signet ring cell adenocarcinoma 10.4 TP53 KRAS HRAS
13 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
14 descending colon cancer 10.4 KRAS HRAS
15 larynx squamous papilloma 10.4 TP53 HRAS CDKN2A
16 thymus basaloid carcinoma 10.4 SYP NKX2-1
17 lung meningioma 10.4 SYP NKX2-1
18 differentiated thyroid carcinoma 10.4 NKX2-1 KRAS HRAS
19 subleukemic leukemia 10.4 SYP SCGB1A1
20 nasal cavity adenocarcinoma 10.4 KRT7 HRAS
21 ureter adenocarcinoma 10.4 NKX2-1 KRT7
22 adenosquamous lung carcinoma 10.4 KRAS HRAS EGFR
23 pancreatic foamy gland adenocarcinoma 10.4 TP53 KRT7
24 mismatch repair cancer syndrome 10.4 TP53 KRAS HRAS
25 mucinous bronchioloalveolar adenocarcinoma 10.4 NKX2-1 KRT7
26 acneiform dermatitis 10.4 KRAS HRAS EGFR
27 inverted transitional papilloma 10.4 KRT7 CDKN2A
28 alveoli adenoma 10.4 SFTPC SCGB1A1 NKX2-1
29 duodenal benign neoplasm 10.4 SYP HRAS
30 neonatal respiratory failure 10.4 SFTPC SCGB1A1 NKX2-1
31 myoma 10.4 TP53 KRAS EGFR
32 ampulla of vater benign neoplasm 10.4 SYP KRAS HRAS
33 bronchus adenoma 10.4 NKX2-1 NAPSA
34 bile duct mucinous adenocarcinoma 10.4 TP53 SYP
35 malignant spiradenoma 10.4 TP53 KRT7
36 paronychia 10.4 KRAS HRAS EGFR
37 atrophic vulva 10.4 KRT7 CDKN2A
38 vulvar sebaceous carcinoma 10.4 TP53 KRT7
39 bladder urachal carcinoma 10.4 KRT7 KRAS HRAS
40 urachus cancer 10.4 KRT7 KRAS HRAS
41 carotid body cancer 10.4 SYP NKX2-1
42 dermatopathia pigmentosa reticularis 10.4 KRAS HRAS EGFR
43 mucinous intrahepatic cholangiocarcinoma 10.4 KRT7 KRAS HRAS
44 sigmoid neoplasm 10.4 KRT7 KRAS HRAS
45 appendiceal neoplasm 10.4 KRT7 KRAS HRAS
46 vulvar eccrine porocarcinoma 10.4 SYP CDKN2A
47 thyroid tumor 10.4 KRAS HRAS AKT1
48 necrotizing sialometaplasia 10.4 TP53 KRT7
49 lung non-squamous non-small cell carcinoma 10.4 KRAS HRAS EGFR
50 esophagus verrucous carcinoma 10.4 TP53 EGFR CDKN2A

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:



Diseases related to Respiratory System Benign Neoplasm

Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

25 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.78 EGFR HRAS KRAS
2 Decreased viability GR00055-A-2 9.78 EGFR HRAS KRAS
3 Decreased viability GR00055-A-3 9.78 KRAS
4 Decreased viability GR00106-A-0 9.78 KRAS
5 Decreased viability GR00221-A-1 9.78 AKT1 CDKN2A EGFR HRAS KRAS MYC
6 Decreased viability GR00221-A-2 9.78 AKT1 HRAS KRAS
7 Decreased viability GR00221-A-3 9.78 AKT1 CDKN2A HRAS MYC
8 Decreased viability GR00221-A-4 9.78 AKT1 CDKN2A EGFR
9 Decreased viability GR00249-S 9.78 AKT1 MYC
10 Decreased viability GR00301-A 9.78 KRAS
11 Decreased viability GR00381-A-1 9.78 KRAS
12 Decreased viability GR00402-S-2 9.78 MYC

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10 AKT1 CDKN2A DNAI7 EGFR HRAS KRAS
2 normal MP:0002873 9.81 AKT1 EGFR HRAS KRAS MYC NKX2-1
3 pigmentation MP:0001186 9.8 CDKN2A EGFR KRAS MLANA MYC TP53
4 no phenotypic analysis MP:0003012 9.65 CDKN2A EGFR HRAS KRAS MIR30C1 MLANA
5 respiratory system MP:0005388 9.28 AKT1 CDKN2A EGFR HRAS KRAS NKX2-1

Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Respiratory System Benign Neoplasm

Genetic Tests for Respiratory System Benign Neoplasm

Anatomical Context for Respiratory System Benign Neoplasm

Publications for Respiratory System Benign Neoplasm

Variations for Respiratory System Benign Neoplasm

Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TP53 SFTPC MYC KRAS HRAS H2AC18
2
Show member pathways
12.99 MYC KRAS HRAS H2AC18 EGFR AKT1
3
Show member pathways
12.95 TP53 MYC KRAS HRAS EGFR AKT1
4
Show member pathways
12.94 TP53 MYC HRAS EGFR CDKN2A AKT1
5
Show member pathways
12.86 TP53 MYC KRAS HRAS AKT1
6 12.85 MYC KRAS HRAS EGFR AKT1
7
Show member pathways
12.78 TP53 MYC H2AC18 EGFR AKT1
8
Show member pathways
12.67 KRAS HRAS EGFR CDKN2A AKT1
9
Show member pathways
12.67 TP53 KRAS HRAS EGFR AKT1
10 12.65 TP53 MYC HRAS EGFR CDKN2A AKT1
11
Show member pathways
12.62 TP53 MYC KRAS HRAS EGFR AKT1
12
Show member pathways
12.54 TP53 MYC KRAS HRAS EGFR AKT1
13
Show member pathways
12.49 TP53 MYC KRAS HRAS EGFR CDKN2A
14
Show member pathways
12.42 KRAS HRAS EGFR AKT1
15
Show member pathways
12.42 TP53 KRAS HRAS EGFR AKT1
16
Show member pathways
12.37 TP53 MYC KRAS HRAS EGFR AKT1
17
Show member pathways
12.33 AKT1 EGFR HRAS KRAS MYC TP53
18
Show member pathways
12.27 TP53 MYC HRAS AKT1
19 12.27 TP53 MYC KRAS HRAS EGFR AKT1
20 12.26 KRAS HRAS EGFR AKT1
21
Show member pathways
12.23 KRAS HRAS EGFR AKT1
22 12.19 AKT1 HRAS KRAS TP53
23
Show member pathways
12.16 KRAS HRAS EGFR AKT1
24 12.16 TP53 MYC KRAS EGFR AKT1
25
Show member pathways
12.16 TP53 MYC KRAS HRAS EGFR AKT1
26
Show member pathways
12.15 TP53 HRAS CDKN2A AKT1
27
Show member pathways
12.13 AKT1 HRAS KRAS MYC TP53
28 12.09 TP53 KRAS EGFR AKT1
29 12.09 TP53 MYC KRAS EGFR AKT1
30
Show member pathways
12.04 KRAS HRAS EGFR AKT1
31 11.9 TP53 MYC KRAS HRAS
32
Show member pathways
11.88 MYC KRAS HRAS EGFR AKT1
33
Show member pathways
11.8 KRAS HRAS AKT1
34
Show member pathways
11.77 AKT1 CDKN2A TP53
35
Show member pathways
11.77 TP53 KRAS HRAS AKT1
36 11.73 TP53 MYC CDKN2A
37 11.73 MYC EGFR AKT1
38 11.72 TP53 MYC MIR106B
39 11.7 MYC EGFR AKT1
40 11.68 TP53 HRAS AKT1
41 11.68 MYC KRAS HRAS EGFR CDKN2A AKT1
42
Show member pathways
11.66 KRAS HRAS AKT1
43 11.63 EGFR HRAS KRAS
44
Show member pathways
11.62 MYC HRAS EGFR AKT1
45 11.61 TP53 MYC AKT1
46 11.57 TP53 CDKN2A AKT1
47 11.53 HRAS EGFR AKT1
48 11.42 KRAS HRAS AKT1
49 11.41 TP53 MYC AKT1
50 11.41 KRAS HRAS AKT1

GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alveolar lamellar body GO:0097208 8.92 SFTPC NAPSA

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 MYC KRAS HRAS EGFR
2 cell population proliferation GO:0008283 9.8 TP53 LMNTD1 KRAS EGFR AKT1
3 Ras protein signal transduction GO:0007265 9.76 CDKN2A HRAS KRAS TP53
4 positive regulation of gene expression GO:0010628 9.73 TP53 NKX2-1 MYC KRAS HRAS CDKN2A
5 response to UV-A GO:0070141 9.62 EGFR AKT1
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.1 SYP KRAS HRAS

Sources for Respiratory System Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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