Respiratory System Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RSP004 MIFTS: 30	Respiratory System Benign Neoplasm Categories: Cancer diseases, Respiratory diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Benign neoplasms

Benign neoplasm of middle ear and respiratory system

Benign neoplasm: Respiratory system, unspecified

External Ids:

Disease Ontology ¹² DOID:0050621

ICD10 ³² D14.4

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Summaries for Respiratory System Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)

#	Related Disease	Score	Top Affiliating Genes
1	pleural lipoma	11.3
2	trachea leiomyoma	11.3
3	signet ring basal cell carcinoma	10.7	KRAS HRAS
4	nasal cavity adenocarcinoma	10.6	KRAS HRAS
5	hyperplastic polyposis syndrome	10.6	TP53 KRAS
6	periampullary adenoma	10.6	KRAS HRAS
7	wolffian duct adenocarcinoma	10.6	TP53 KRAS HRAS
8	vulvar intraepithelial neoplasia	10.6	TP53 CDKN2A
9	tumor of exocrine pancreas	10.6	TP53 KRAS HRAS
10	esophageal leukoplakia	10.6	TP53 CCND1
11	appendix disease	10.6	TP53 KRAS HRAS
12	breast squamous cell carcinoma	10.6	TP53 HRAS
13	appendix cancer	10.6	TP53 KRAS HRAS
14	chromosome 14q11-q22 deletion syndrome	10.6	NKX2-1 HRAS
15	trachea carcinoma in situ	10.6	KRAS HRAS CDKN2A
16	lung meningioma	10.6	SYP NKX2-1
17	female reproductive endometrioid cancer	10.6	TP53 KRAS HRAS
18	endometrial transitional cell carcinoma	10.6	SYP CDKN2A
19	cystadenocarcinoma	10.6	TP53 HRAS AKT1
20	small cell carcinoma of the bladder	10.6	SYP NKX2-1
21	duodenum disease	10.6	TP53 KRAS HRAS
22	papillary serous adenocarcinoma	10.6	TP53 NKX2-1 KRAS
23	acneiform dermatitis	10.6	KRAS HRAS EGFR
24	ampulla of vater neoplasm	10.6	SYP KRAS HRAS
25	rare adenocarcinoma of the breast	10.6	TP53 KRAS
26	laryngeal neuroendocrine tumor	10.6	TP53 SYP
27	signet ring cell adenocarcinoma	10.6	TP53 KRAS HRAS
28	spitz nevus	10.6	TP53 HRAS CDKN2A
29	bile duct mucinous adenocarcinoma	10.6	TP53 SYP
30	appendix adenocarcinoma	10.6	SYP KRAS HRAS
31	malignant peritoneal mesothelioma	10.6	EGFR CDKN2A
32	ovarian seromucinous carcinoma	10.6	TP53 CDKN2A
33	paronychia	10.6	KRAS HRAS EGFR
34	anal canal paget's disease	10.6	MLANA CDKN2A
35	thyroid tumor	10.6	TP53 KRAS HRAS
36	pancreatic acinar cell adenocarcinoma	10.6	SYP KRAS HRAS
37	esophageal basaloid squamous cell carcinoma	10.5	TP53 EGFR
38	adult malignant schwannoma	10.5	TP53 HRAS CDKN2A
39	duodenal benign neoplasm	10.5	SYP HRAS
40	pancreatic foamy gland adenocarcinoma	10.5	TP53 CCND1
41	papillary adenocarcinoma	10.5	TP53 NKX2-1 KRAS
42	vulvar eccrine porocarcinoma	10.5	SYP CDKN2A
43	malignant anus melanoma	10.5	MLANA HRAS
44	primary cutaneous diffuse large b-cell lymphoma, leg type	10.5	MYC CDKN2A
45	plexiform neurofibroma	10.5	TP53 HRAS CDKN2A
46	chordoid glioma	10.5	TP53 SYP NKX2-1
47	anal carcinoma in situ	10.5	TP53 MYC
48	small intestine cancer	10.5	TP53 KRAS HRAS
49	eccrine papillary adenoma	10.5	KRAS HRAS
50	pleomorphic carcinoma	10.5	TP53 NKX2-1 EGFR

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:

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Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	10.17	EGFR HRAS KRAS
2	Decreased viability	GR00106-A-0	10.17	KRAS
3	Decreased viability	GR00221-A-1	10.17	AKT1 CDKN2A EGFR HRAS KRAS MYC
4	Decreased viability	GR00221-A-2	10.17	AKT1 HRAS KRAS RAF1
5	Decreased viability	GR00221-A-3	10.17	AKT1 CDKN2A HRAS MYC
6	Decreased viability	GR00221-A-4	10.17	AKT1 CDKN2A EGFR
7	Decreased viability	GR00231-A	10.17	RAF1
8	Decreased viability	GR00301-A	10.17	KRAS RAF1
9	Decreased viability	GR00381-A-1	10.17	KRAS
10	Decreased viability	GR00402-S-2	10.17	AKT1 CDKN2A EGFR HRAS KRAS MYC
11	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.47	AKT1 CASC1 CDKN2A LMNTD1 RAF1 TP53
12	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.47	AKT1 CASC1 CCND1 CDKN2A LMNTD1 MYC

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.26	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
2	growth/size/body region	MP:0005378	10.23	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
3	endocrine/exocrine gland	MP:0005379	10.22	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
4	neoplasm	MP:0002006	10.22	AKT1 CASC1 CCND1 CDKN2A EGFR HRAS
5	integument	MP:0010771	10.17	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
6	nervous system	MP:0003631	10.11	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
7	digestive/alimentary	MP:0005381	10.1	CCND1 CDKN2A EGFR HRAS KRAS MYC
8	craniofacial	MP:0005382	10.05	CCND1 EGFR HRAS KRAS MYC RAF1
9	no phenotypic analysis	MP:0003012	10.02	CDKN2A EGFR HRAS KRAS MLANA MYC
10	normal	MP:0002873	10	AKT1 CCND1 EGFR HRAS KRAS MYC
11	respiratory system	MP:0005388	9.7	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
12	pigmentation	MP:0001186	9.63	CDKN2A EGFR KRAS MLANA MYC TP53
13	skeleton	MP:0005390	9.32	AKT1 CCND1 CDKN2A EGFR HRAS KRAS

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Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

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Genetic Tests for Respiratory System Benign Neoplasm

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Anatomical Context for Respiratory System Benign Neoplasm

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Publications for Respiratory System Benign Neoplasm

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Genes for Respiratory System Benign Neoplasm

Genes related to Respiratory System Benign Neoplasm (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR30C1	MicroRNA 30c-1	RNA Gene	8.63	DISEASES inferred ¹⁵ ¹⁵
2	MIR362	MicroRNA 362	RNA Gene	7.32	DISEASES inferred ¹⁵ ¹⁵
3	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7.29	DISEASES inferred ¹⁵
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.2	DISEASES inferred ¹⁵
5	NKX2-1	NK2 Homeobox 1	Protein Coding	7	DISEASES inferred ¹⁵
6	CASC1	Cancer Susceptibility 1	Protein Coding	6.93	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	6.89	DISEASES inferred ¹⁵
8	H2AC18	H2A Clustered Histone 18	Protein Coding	6.81	DISEASES inferred ¹⁵ ¹⁵
9	LMNTD1	Lamin Tail Domain Containing 1	Protein Coding	6.71	DISEASES inferred ¹⁵
10	LRMP	Lymphoid Restricted Membrane Protein	Protein Coding	6.66	DISEASES inferred ¹⁵
11	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	6.59	DISEASES inferred ¹⁵
12	SFTPC	Surfactant Protein C	Protein Coding	6.43	DISEASES inferred ¹⁵
13	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.29	DISEASES inferred ¹⁵
14	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.22	DISEASES inferred ¹⁵
15	SYP	Synaptophysin	Protein Coding	6.02	DISEASES inferred ¹⁵
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.92	DISEASES inferred ¹⁵
17	MLANA	Melan-A	Protein Coding	5.84	DISEASES inferred ¹⁵
18	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.81	DISEASES inferred ¹⁵
19	CCND1	Cyclin D1	Protein Coding	5.72	DISEASES inferred ¹⁵
20	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5.67	DISEASES inferred ¹⁵
21	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.66	DISEASES inferred ¹⁵
22	CHGA	Chromogranin A	Protein Coding	5.62	DISEASES inferred ¹⁵
23	KRT7	Keratin 7	Protein Coding	5.58	DISEASES inferred ¹⁵
24	C18orf54	Chromosome 18 Open Reading Frame 54	Protein Coding	5.56	DISEASES inferred ¹⁵
25	SERPINB3	Serpin Family B Member 3	Protein Coding	5.56	DISEASES inferred ¹⁵
26	CD34	CD34 Molecule	Protein Coding	5.51	DISEASES inferred ¹⁵
27	KRT5	Keratin 5	Protein Coding	5.46	DISEASES inferred ¹⁵
28	ENO2	Enolase 2	Protein Coding	5.45	DISEASES inferred ¹⁵
29	CDH1	Cadherin 1	Protein Coding	5.4	DISEASES inferred ¹⁵
30	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	5.36	DISEASES inferred ¹⁵
31	TSC2	TSC Complex Subunit 2	Protein Coding	5.36	DISEASES inferred ¹⁵

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Variations for Respiratory System Benign Neoplasm

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Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

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Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 148)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.94	TP53 RAF1 MYC KRAS HRAS EGFR
2	GPCR Pathway ⁶³ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶³ Estrogen Pathway ⁶³ NFAT in Immune Response ⁶³ P2Y Receptor Signaling ⁶³ Pancreatic Adenocarcinoma ⁶³ Paxillin Interactions ⁶³ Ras Pathway ⁶³	13.82	TP53 RAF1 MYC KRAS HRAS EGFR
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.49	TP53 RAF1 MYC KRAS HRAS EGFR
4	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.34	TP53 RAF1 MYC KRAS HRAS EGFR
5	Toll-like Receptor Signaling Pathway ¹ ³⁶ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ NOD-like Receptor Signaling Pathways ⁶⁴ Regulation of toll-like receptor signaling pathway ¹	13.24	TP53 RAF1 MYC KRAS HRAS EGFR
6	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	13.18	TP53 RAF1 KRAS HRAS EGFR AKT1
7	G-Beta Gamma Signaling ⁶³ Show member pathways CRHR Pathway ⁶³ GHRH Signaling ⁶³ Hedgehog Signaling in Mammals ⁶³ Relaxin Pathway ⁶³ Signaling in Gap Junctions ⁶³	13.15	RAF1 KRAS HRAS EGFR CDKN2A AKT1
8	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.08	TP53 RAF1 MYC KRAS HRAS EGFR
9	TNFR1 Pathway ⁶³ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶³ Apoptotic Pathways Triggered By HIV1 ⁶³ DR3 Signaling ⁶³ Fas Signaling ⁶³ GITR Pathway ⁶³ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁵ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶³ TRAIL Pathway ⁶³ TWEAK Pathway ⁶³	13.07	TP53 RAF1 KRAS HRAS EGFR AKT1
10	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13.04	TP53 RAF1 MYC KRAS HRAS EGFR
11	Aldosterone synthesis and secretion ³⁶ Show member pathways Ca2+ activated K+ channels ⁶⁵ Cortisol synthesis and secretion ³⁶ Cushing syndrome ³⁶ Insulin secretion ³⁶ Melanogenesis ³⁶ Thyroid hormone synthesis ³⁶	13.03	RAF1 KRAS HRAS EGFR CDKN2A CCND1
12	Focal Adhesion ¹ ³⁶ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	13.02	RAF1 KRAS HRAS EGFR CCND1 AKT1
13	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.95	RAF1 KRAS HRAS EGFR AKT1
14	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.92	TP53 RAF1 MYC CCND1 AKT1
15	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴ Death Receptor Signaling ⁶⁶	12.92	TP53 RAF1 MYC KRAS HRAS CDKN2A
16	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.92	TP53 RAF1 MYC KRAS HRAS EGFR
17	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁴ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²²	12.91	RAF1 MYC KRAS HRAS CCND1 AKT1
18	Pathways in cancer ³⁶	12.89	TP53 RAF1 MYC KRAS HRAS EGFR
19	MAPK signaling pathway ¹ ³⁶	12.87	TP53 RAF1 MYC KRAS HRAS EGFR
20	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.85	RAF1 KRAS HRAS EGFR AKT1
21	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.84	TP53 KRAS HRAS EGFR AKT1
22	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.83	TP53 RAF1 KRAS HRAS AKT1
23	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.8	TP53 RAF1 KRAS HRAS EGFR AKT1
24	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.79	RAF1 KRAS HRAS EGFR AKT1
25	G-AlphaQ Signaling ⁶³ Show member pathways G-AlphaI Signaling ⁶³ Thrombin Signaling ⁶³	12.79	RAF1 KRAS HRAS EGFR AKT1
26	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.78	TP53 RAF1 MYC KRAS HRAS EGFR
27	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.77	RAF1 KRAS HRAS EGFR CCND1 AKT1
28	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.76	TP53 RAF1 KRAS HRAS EGFR CDKN2A
29	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.73	RAF1 KRAS HRAS EGFR AKT1
30	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.72	RAF1 NKX2-1 HRAS CCND1 AKT1
31	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.72	TP53 MYC KRAS HRAS EGFR AKT1
32	Mitotic G1-G1/S phases ⁶⁵ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁵	12.7	TP53 MYC CDKN2A CCND1 AKT1
33	ErbB signaling pathway ¹ ³⁶ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.69	TP53 RAF1 MYC KRAS HRAS EGFR
34	Development ERBB-family signaling ²² Show member pathways Development EGFR signaling pathway ²² EGF Pathway ⁶³ EGFR Signaling Pathway ⁶⁶ ErbB receptor signaling network ¹ GRB7 events in ERBB2 signaling ⁶⁵ PLCG1 events in ERBB2 signaling ⁶⁵	12.64	TP53 RAF1 MYC KRAS HRAS EGFR
35	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.63	TP53 RAF1 KRAS HRAS EGFR AKT1
36	Oxytocin signaling pathway ³⁶ Show member pathways Vascular smooth muscle contraction ³⁶	12.62	RAF1 KRAS HRAS EGFR CCND1
37	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.6	RAF1 MYC KRAS HRAS CCND1 AKT1
38	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.58	TP53 KRAS HRAS EGFR AKT1
39	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁶ AMPK Signaling Pathway ⁶⁶	12.57	TP53 RAF1 HRAS CCND1 AKT1
40	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² VEGF Family Ligands and Receptor Interactions ⁶³ VEGF Pathway ⁶³	12.55	RAF1 KRAS HRAS EGFR AKT1
41	B cell receptor signaling pathway (KEGG) ¹ Show member pathways B cell receptor signaling pathway ³⁶ BCR signaling pathway ¹	12.55	RAF1 MYC KRAS HRAS AKT1
42	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.54	RAF1 KRAS HRAS EGFR AKT1
43	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶³	12.51	RAF1 KRAS HRAS AKT1
44	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.51	TP53 RAF1 MYC HRAS CCND1 AKT1
45	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	12.5	RAF1 KRAS HRAS AKT1
46	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.48	TP53 MYC CDKN2A CCND1
47	JAK-STAT signaling pathway (KEGG) ³⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴	12.48	RAF1 MYC HRAS EGFR CCND1 AKT1
48	Cell cycle ¹ ³⁶	12.47	TP53 MYC CDKN2A CCND1
49	MicroRNAs in cancer ³⁶	12.47	TP53 RAF1 MYC MIR30C1 KRAS HRAS
50	Cyclins and Cell Cycle Regulation ⁶³ Show member pathways Cell Cycle Control by BTG Proteins ⁶³ Cyclin D associated events in G1 ⁶⁵ G1 Phase ⁶⁵ G1-S Phase Transition ⁶³ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁵	12.46	TP53 RAF1 CDKN2A CCND1

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GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear envelope	GO:0005635	8.92	SCGB1A1 MYC LRMP LMNTD1

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 25)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	10.02	TP53 NKX2-1 MYC EGFR CDKN2A AKT1
2	positive regulation of transcription by RNA polymerase II	GO:0045944	10.01	TP53 RAF1 NKX2-1 MYC HRAS EGFR
3	positive regulation of cell proliferation	GO:0008284	9.97	MYC KRAS HRAS EGFR CCND1 AKT1
4	cell proliferation	GO:0008283	9.9	TP53 LMNTD1 EGFR AKT1
5	cytokine-mediated signaling pathway	GO:0019221	9.88	TP53 MYC KRAS CCND1 AKT1
6	MAPK cascade	GO:0000165	9.83	RAF1 MYC KRAS HRAS EGFR
7	cell cycle arrest	GO:0007050	9.81	TP53 MYC HRAS CDKN2A
8	liver development	GO:0001889	9.8	KRAS EGFR CCND1
9	cellular response to drug	GO:0035690	9.77	TP53 MYC EGFR
10	response to glucocorticoid	GO:0051384	9.76	SCGB1A1 KRAS CCND1
11	positive regulation of MAP kinase activity	GO:0043406	9.74	KRAS HRAS EGFR
12	positive regulation of G1/S transition of mitotic cell cycle	GO:1900087	9.71	EGFR CCND1 AKT1
13	cellular response to reactive oxygen species	GO:0034614	9.7	TP53 EGFR AKT1
14	positive regulation of gene expression	GO:0010628	9.7	TP53 NKX2-1 MYC KRAS HRAS CDKN2A
15	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045737	9.63	EGFR CCND1 AKT1
16	Leydig cell differentiation	GO:0033327	9.62	NKX2-1 CCND1
17	Ras protein signal transduction	GO:0007265	9.62	TP53 KRAS HRAS CDKN2A
18	cerebral cortex cell migration	GO:0021795	9.61	NKX2-1 EGFR
19	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.61	TP53 EGFR
20	mitotic G1 DNA damage checkpoint	GO:0031571	9.58	TP53 CCND1
21	response to isolation stress	GO:0035900	9.56	KRAS HRAS
22	positive regulation of epithelial cell proliferation	GO:0050679	9.56	MYC HRAS EGFR CCND1
23	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.54	SYP KRAS HRAS
24	positive regulation of protein phosphorylation	GO:0001934	9.43	RAF1 KRAS HRAS EGFR CCND1 AKT1
25	response to UV-A	GO:0070141	8.8	EGFR CCND1 AKT1

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.55	TP53 EGFR CDKN2A CCND1 AKT1
2	enzyme binding	GO:0019899	9.1	TP53 RAF1 NKX2-1 EGFR CCND1 AKT1
3	nitric-oxide synthase regulator activity	GO:0030235	8.96	EGFR AKT1

Sources

Sources for Respiratory System Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

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³⁰ HMDB

³¹ HPO

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³³ ICD10 via Orphanet

³⁴ ICD9CM

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³⁷ LifeMap

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁶¹ PubMed

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⁶⁸ SNOMED-CT via HPO

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia