MCID: RSP004
MIFTS: 28

Respiratory System Benign Neoplasm

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050621
ICD10 32 D14.4

Summaries for Respiratory System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and PI3K-Akt signaling pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)
# Related Disease Score Top Affiliating Genes
1 pleural lipoma 11.2
2 trachea leiomyoma 11.2
3 hepatic flexure cancer 10.5 KRAS HRAS
4 signet ring basal cell carcinoma 10.5 KRAS HRAS
5 cobblestone retinal degeneration 10.5 KRAS HRAS
6 immature teratoma of ovary 10.5 KRAS HRAS
7 descending colon cancer 10.5 KRAS HRAS
8 ovarian clear cell adenofibroma 10.5 NAPSA KRAS
9 trachea carcinoma in situ 10.4 KRAS HRAS CDKN2A
10 large intestine adenocarcinoma 10.4 TP53 KRAS HRAS
11 vulvar intraepithelial neoplasia 10.4 TP53 CDKN2A
12 periampullary adenoma 10.4 KRAS HRAS
13 acneiform dermatitis 10.4 KRAS HRAS EGFR
14 adenosquamous lung carcinoma 10.4 KRAS HRAS EGFR
15 anal carcinoma in situ 10.4 TP53 MYC
16 spitz nevus 10.4 TP53 HRAS CDKN2A
17 paronychia 10.4 KRAS HRAS EGFR
18 ethmoid sinus adenocarcinoma 10.4 KRAS HRAS EGFR
19 squamous cell papilloma 10.4 TP53 HRAS CDKN2A
20 thymus basaloid carcinoma 10.4 SYP NKX2-1
21 lung meningioma 10.4 SYP NKX2-1
22 ureter adenocarcinoma 10.4 NKX2-1 KRT7
23 adult malignant schwannoma 10.4 TP53 HRAS CDKN2A
24 oculoectodermal syndrome 10.4 KRAS HRAS AKT1
25 lung non-squamous non-small cell carcinoma 10.4 KRAS HRAS EGFR
26 malignant peritoneal mesothelioma 10.4 EGFR CDKN2A
27 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
28 ampulla of vater neoplasm 10.4 SYP KRAS HRAS
29 alveoli adenoma 10.4 SFTPC SCGB1A1 NKX2-1
30 bronchial benign neoplasm 10.4 SFTPC SCGB1A1 NKX2-1
31 prostate squamous cell carcinoma 10.4 TP53 HRAS CDKN2A
32 neonatal respiratory failure 10.4 SFTPC SCGB1A1 NKX2-1
33 esophageal basaloid squamous cell carcinoma 10.4 TP53 EGFR
34 nodular malignant melanoma 10.4 TP53 HRAS CDKN2A
35 pancreatic acinar cell adenocarcinoma 10.4 SYP KRAS HRAS
36 sarcomatoid transitional cell carcinoma 10.4 TP53 SYP
37 bile duct mucinous adenocarcinoma 10.4 TP53 SYP
38 inverted transitional papilloma 10.4 KRT7 CDKN2A
39 pancreatic foamy gland adenocarcinoma 10.4 TP53 KRT7
40 human papillomavirus infectious disease 10.4 TP53 CDKN2A
41 transverse colon cancer 10.4 KRT7 KRAS HRAS
42 appendiceal neoplasm 10.4 KRT7 KRAS HRAS
43 gallbladder benign neoplasm 10.4 KRT7 KRAS HRAS
44 carotid body cancer 10.4 SYP NKX2-1
45 wolffian duct adenocarcinoma 10.4 KRT7 KRAS HRAS
46 myoepithelial carcinoma 10.4 TP53 KRT7 HRAS
47 barrett's adenocarcinoma 10.4 TP53 KRAS CDKN2A
48 esophagus verrucous carcinoma 10.4 TP53 EGFR CDKN2A
49 anal canal paget's disease 10.4 KRT7 CDKN2A
50 verrucous carcinoma 10.4 TP53 EGFR CDKN2A

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:



Diseases related to Respiratory System Benign Neoplasm

Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.78 EGFR HRAS KRAS
2 Decreased viability GR00055-A-2 9.78 EGFR HRAS KRAS
3 Decreased viability GR00055-A-3 9.78 KRAS
4 Decreased viability GR00106-A-0 9.78 KRAS
5 Decreased viability GR00221-A-1 9.78 AKT1 CDKN2A EGFR HRAS KRAS MYC
6 Decreased viability GR00221-A-2 9.78 AKT1 HRAS KRAS
7 Decreased viability GR00221-A-3 9.78 AKT1 CDKN2A HRAS MYC
8 Decreased viability GR00221-A-4 9.78 AKT1 CDKN2A EGFR
9 Decreased viability GR00249-S 9.78 AKT1 MYC
10 Decreased viability GR00301-A 9.78 KRAS
11 Decreased viability GR00381-A-1 9.78 KRAS
12 Decreased viability GR00402-S-2 9.78 MYC

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10 AKT1 CDKN2A DNAI7 EGFR HRAS KRAS
2 no phenotypic analysis MP:0003012 9.76 CDKN2A EGFR HRAS KRAS MYC NKX2-1
3 normal MP:0002873 9.61 AKT1 EGFR HRAS KRAS MYC NKX2-1
4 respiratory system MP:0005388 9.28 AKT1 CDKN2A EGFR HRAS KRAS NKX2-1

Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

Genetic Tests for Respiratory System Benign Neoplasm

Anatomical Context for Respiratory System Benign Neoplasm

Publications for Respiratory System Benign Neoplasm

Variations for Respiratory System Benign Neoplasm

Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 TP53 MYC KRAS HRAS EGFR AKT1
2
Show member pathways
13.03 TP53 MYC KRAS HRAS EGFR AKT1
3
Show member pathways
12.98 TP53 MYC KRAS HRAS EGFR CDKN2A
4
Show member pathways
12.88 TP53 MYC KRAS HRAS EGFR CDKN2A
5 12.82 TP53 MYC KRAS HRAS EGFR CDKN2A
6 12.8 TP53 MYC KRAS HRAS EGFR AKT1
7
Show member pathways
12.76 TP53 KRAS HRAS EGFR AKT1
8
Show member pathways
12.75 TP53 MYC KRAS HRAS CDKN2A AKT1
9
Show member pathways
12.72 TP53 KRAS HRAS EGFR CDKN2A AKT1
10
Show member pathways
12.71 TP53 KRAS HRAS EGFR AKT1
11
Show member pathways
12.71 TP53 MYC KRAS HRAS EGFR CDKN2A
12
Show member pathways
12.67 TP53 MYC KRAS HRAS EGFR AKT1
13
Show member pathways
12.63 TP53 MYC KRAS HRAS EGFR AKT1
14
Show member pathways
12.55 TP53 KRAS HRAS EGFR AKT1
15
Show member pathways
12.49 TP53 KRAS HRAS EGFR AKT1
16
Show member pathways
12.48 TP53 MYC KRAS HRAS EGFR AKT1
17
Show member pathways
12.45 MYC HRAS EGFR AKT1
18
Show member pathways
12.44 MYC KRAS HRAS AKT1
19
Show member pathways
12.44 KRAS HRAS EGFR AKT1
20
Show member pathways
12.43 TP53 MYC HRAS AKT1
21 12.4 TP53 MYC MIR30C1 KRAS HRAS EGFR
22
Show member pathways
12.37 MYC KRAS HRAS EGFR AKT1
23
Show member pathways
12.36 TP53 HRAS EGFR AKT1
24
Show member pathways
12.35 TP53 KRAS HRAS EGFR AKT1
25 12.34 TP53 KRAS HRAS CDKN2A
26
Show member pathways
12.33 KRAS HRAS EGFR AKT1
27
Show member pathways
12.31 TP53 MYC KRAS EGFR AKT1
28 12.27 TP53 MYC KRAS HRAS CDKN2A AKT1
29
Show member pathways
12.26 TP53 MYC KRAS HRAS EGFR AKT1
30 12.23 KRAS HRAS EGFR AKT1
31 12.23 TP53 MYC KRAS EGFR AKT1
32
Show member pathways
12.22 TP53 KRAS HRAS AKT1
33
Show member pathways
12.19 TP53 KRAS HRAS AKT1
34 12.19 TP53 MYC KRAS HRAS EGFR AKT1
35 12.16 MYC KRAS HRAS AKT1
36 12.16 TP53 MYC KRAS EGFR AKT1
37
Show member pathways
12.15 TP53 MYC KRAS HRAS AKT1
38
Show member pathways
12.13 KRAS HRAS EGFR AKT1
39
Show member pathways
12.13 MYC KRAS HRAS EGFR AKT1
40
Show member pathways
12.12 MYC KRAS HRAS AKT1
41
Show member pathways
12.11 KRAS HRAS EGFR AKT1
42
Show member pathways
12.09 TP53 KRAS HRAS EGFR AKT1
43 12.06 TP53 KRAS HRAS AKT1
44 11.99 TP53 MYC KRAS HRAS CDKN2A AKT1
45 11.96 TP53 MYC KRAS HRAS AKT1
46
Show member pathways
11.85 KRAS HRAS AKT1
47
Show member pathways
11.79 TP53 CDKN2A AKT1
48 11.79 TP53 MYC KRAS HRAS CDKN2A AKT1
49 11.78 TP53 CDKN2A AKT1
50 11.78 KRAS HRAS AKT1

GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 9.46 SCGB1A1 MYC LMNTD1 IRAG2
2 multivesicular body lumen GO:0097486 8.96 SFTPC NAPSA
3 alveolar lamellar body GO:0097208 8.62 SFTPC NAPSA

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 TP53 NKX2-1 MYC HRAS EGFR CDKN2A
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 TP53 NKX2-1 MYC EGFR CDKN2A AKT1
3 positive regulation of protein phosphorylation GO:0001934 9.78 KRAS HRAS EGFR AKT1
4 cellular response to drug GO:0035690 9.69 TP53 MYC EGFR
5 positive regulation of epithelial cell proliferation GO:0050679 9.63 MYC HRAS EGFR
6 cell cycle arrest GO:0007050 9.62 TP53 MYC HRAS CDKN2A
7 positive regulation of MAP kinase activity GO:0043406 9.58 KRAS HRAS EGFR
8 response to isolation stress GO:0035900 9.49 KRAS HRAS
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.33 SYP KRAS HRAS
10 response to UV-A GO:0070141 9.26 EGFR AKT1
11 Ras protein signal transduction GO:0007265 9.26 TP53 KRAS HRAS CDKN2A
12 positive regulation of gene expression GO:0010628 9.17 TP53 NKX2-1 MYC KRAS HRAS CDKN2A

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
2 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR AKT1

Sources for Respiratory System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....