MCID: RSP004
MIFTS: 29

Respiratory System Benign Neoplasm

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050621
ICD10 32 D14.4

Summaries for Respiratory System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)
# Related Disease Score Top Affiliating Genes
1 pleural lipoma 11.3
2 trachea leiomyoma 11.3
3 signet ring basal cell carcinoma 10.7 KRAS HRAS
4 cobblestone retinal degeneration 10.7 KRAS HRAS
5 villous adenoma 10.6 TP53 KRAS HRAS
6 ovarian clear cell adenofibroma 10.6 NAPSA KRAS
7 hyperplastic polyposis syndrome 10.6 TP53 KRAS
8 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
9 trachea carcinoma in situ 10.6 KRAS HRAS CDKN2A
10 endometrial squamous cell carcinoma 10.6 TP53 CDKN2A
11 large intestine adenocarcinoma 10.6 TP53 KRAS HRAS
12 lung meningioma 10.6 SYP NKX2-1
13 female reproductive endometrioid cancer 10.6 TP53 KRAS HRAS
14 ureter adenocarcinoma 10.6 NKX2-1 KRT7
15 adenosquamous lung carcinoma 10.6 KRAS HRAS EGFR
16 acneiform dermatitis 10.6 KRAS HRAS EGFR
17 cervical basaloid squamous cell carcinoma 10.6 KRT7 CDKN2A
18 prostate squamous cell carcinoma 10.6 TP53 HRAS CDKN2A
19 ampulla of vater neoplasm 10.6 SYP KRAS HRAS
20 rare adenocarcinoma of the breast 10.6 TP53 KRAS
21 anal paget's disease 10.6 MLANA KRT7
22 spitz nevus 10.6 TP53 HRAS CDKN2A
23 thyroid carcinoma 10.6 NKX2-1 HRAS AKT1
24 malignant peritoneal mesothelioma 10.6 EGFR CDKN2A
25 paronychia 10.6 KRAS HRAS EGFR
26 pancreatic acinar cell adenocarcinoma 10.6 SYP KRAS HRAS
27 descending colon cancer 10.6 KRAS HRAS
28 squamous cell papilloma 10.6 TP53 HRAS CDKN2A
29 bile duct mucinous adenocarcinoma 10.6 TP53 SYP
30 inverted transitional papilloma 10.6 KRT7 CDKN2A
31 periampullary adenoma 10.6 KRAS HRAS
32 lung non-squamous non-small cell carcinoma 10.6 KRAS HRAS EGFR
33 ovary neuroendocrine neoplasm 10.6 SYP KRT7
34 thyroid tumor 10.6 TP53 KRAS HRAS
35 pancreatic foamy gland adenocarcinoma 10.6 TP53 KRT7
36 adult malignant schwannoma 10.6 TP53 HRAS CDKN2A
37 nasal cavity adenocarcinoma 10.6 KRT7 KRAS HRAS
38 apocrine adenoma 10.6 KRT7 KRAS
39 esophageal basaloid squamous cell carcinoma 10.6 TP53 EGFR
40 duodenal benign neoplasm 10.6 SYP HRAS
41 transverse colon cancer 10.6 KRT7 KRAS HRAS
42 neonatal respiratory failure 10.6 SFTPC SCGB1A1 NKX2-1
43 appendiceal neoplasm 10.6 KRT7 KRAS HRAS
44 rete testis neoplasm 10.6 NKX2-1 KRT7
45 primary cutaneous diffuse large b-cell lymphoma, leg type 10.6 MYC CDKN2A
46 vulvar eccrine porocarcinoma 10.6 SYP CDKN2A
47 myoepithelial carcinoma 10.6 TP53 KRT7 HRAS
48 rete testis adenocarcinoma 10.5 NKX2-1 KRT7
49 duodenum adenocarcinoma 10.5 KRT7 KRAS HRAS
50 bile duct cysts 10.5 KRT7 KRAS HRAS

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:



Diseases related to Respiratory System Benign Neoplasm

Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.84 EGFR HRAS KRAS
2 Decreased viability GR00055-A-2 9.84 EGFR HRAS KRAS
3 Decreased viability GR00055-A-3 9.84 KRAS
4 Decreased viability GR00106-A-0 9.84 KRAS
5 Decreased viability GR00221-A-1 9.84 AKT1 CDKN2A EGFR HRAS KRAS MYC
6 Decreased viability GR00221-A-2 9.84 AKT1 HRAS KRAS RAF1
7 Decreased viability GR00221-A-3 9.84 AKT1 CDKN2A HRAS MYC
8 Decreased viability GR00221-A-4 9.84 AKT1 CDKN2A EGFR
9 Decreased viability GR00249-S 9.84 AKT1 MYC
10 Decreased viability GR00301-A 9.84 KRAS RAF1
11 Decreased viability GR00381-A-1 9.84 KRAS
12 Decreased viability GR00402-S-2 9.84 MYC RAF1

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 AKT1 CDKN2A EGFR HRAS KRAS MYC
2 endocrine/exocrine gland MP:0005379 10.1 AKT1 CDKN2A EGFR HRAS KRAS MYC
3 neoplasm MP:0002006 10.1 AKT1 CDKN2A CFAP94 EGFR HRAS KRAS
4 integument MP:0010771 10.07 AKT1 CDKN2A EGFR HRAS IRAG2 KRAS
5 no phenotypic analysis MP:0003012 9.96 CDKN2A EGFR HRAS KRAS MLANA MYC
6 normal MP:0002873 9.85 AKT1 EGFR HRAS KRAS MYC NKX2-1
7 pigmentation MP:0001186 9.43 CDKN2A EGFR KRAS MLANA MYC TP53
8 respiratory system MP:0005388 9.32 AKT1 CDKN2A EGFR HRAS KRAS NKX2-1

Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

Genetic Tests for Respiratory System Benign Neoplasm

Anatomical Context for Respiratory System Benign Neoplasm

Publications for Respiratory System Benign Neoplasm

Variations for Respiratory System Benign Neoplasm

Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TP53 RAF1 MYC KRAS HRAS EGFR
2
Show member pathways
13.31 TP53 RAF1 MYC KRAS HRAS EGFR
3
Show member pathways
13.16 TP53 RAF1 KRAS HRAS EGFR AKT1
4
Show member pathways
13.16 TP53 RAF1 MYC KRAS HRAS EGFR
5
Show member pathways
13.13 RAF1 KRAS HRAS EGFR CDKN2A AKT1
6
Show member pathways
13.09 TP53 RAF1 MYC KRAS HRAS EGFR
7
Show member pathways
13.01 TP53 RAF1 MYC KRAS HRAS EGFR
8
Show member pathways
12.95 TP53 RAF1 MYC KRAS HRAS EGFR
9
Show member pathways
12.93 RAF1 KRAS HRAS EGFR AKT1
10 12.9 TP53 RAF1 MYC KRAS HRAS EGFR
11
Show member pathways
12.87 RAF1 MYC KRAS HRAS AKT1
12 12.86 TP53 RAF1 MYC KRAS HRAS EGFR
13
Show member pathways
12.83 RAF1 KRAS HRAS EGFR AKT1
14
Show member pathways
12.82 TP53 KRAS HRAS EGFR AKT1
15
Show member pathways
12.81 TP53 RAF1 KRAS HRAS AKT1
16
Show member pathways
12.8 TP53 RAF1 MYC KRAS HRAS CDKN2A
17
Show member pathways
12.78 TP53 RAF1 MYC KRAS HRAS EGFR
18
Show member pathways
12.77 RAF1 KRAS HRAS EGFR AKT1
19
Show member pathways
12.77 RAF1 KRAS HRAS EGFR AKT1
20
Show member pathways
12.77 TP53 RAF1 KRAS HRAS EGFR AKT1
21
Show member pathways
12.76 TP53 RAF1 KRAS HRAS EGFR CDKN2A
22
Show member pathways
12.75 RAF1 KRAS HRAS EGFR AKT1
23
Show member pathways
12.71 RAF1 KRAS HRAS EGFR AKT1
24
Show member pathways
12.7 TP53 RAF1 MYC KRAS HRAS EGFR
25
Show member pathways
12.69 TP53 MYC KRAS HRAS EGFR AKT1
26
Show member pathways
12.6 RAF1 MYC KRAS HRAS AKT1
27
Show member pathways
12.6 TP53 RAF1 KRAS HRAS EGFR AKT1
28
Show member pathways
12.57 RAF1 MYC KRAS HRAS EGFR AKT1
29
Show member pathways
12.56 TP53 KRAS HRAS EGFR AKT1
30
Show member pathways
12.56 TP53 RAF1 MYC KRAS HRAS EGFR
31
Show member pathways
12.53 RAF1 KRAS HRAS EGFR AKT1
32
Show member pathways
12.52 RAF1 MYC KRAS HRAS AKT1
33
Show member pathways
12.52 RAF1 KRAS HRAS EGFR AKT1
34
Show member pathways
12.51 TP53 RAF1 MYC HRAS AKT1
35
Show member pathways
12.49 RAF1 KRAS HRAS AKT1
36
Show member pathways
12.49 RAF1 KRAS HRAS AKT1
37 12.46 TP53 RAF1 MYC MIR30C1 KRAS HRAS
38 12.44 TP53 MYC KRAS HRAS CDKN2A AKT1
39
Show member pathways
12.43 RAF1 KRAS HRAS AKT1
40
Show member pathways
12.42 RAF1 MYC HRAS AKT1
41
Show member pathways
12.42 RAF1 HRAS EGFR AKT1
42
Show member pathways
12.42 TP53 RAF1 HRAS EGFR AKT1
43
Show member pathways
12.41 KRAS HRAS EGFR AKT1
44 12.4 RAF1 MYC HRAS AKT1
45 12.4 TP53 KRAS HRAS CDKN2A
46
Show member pathways
12.4 RAF1 MYC KRAS HRAS EGFR AKT1
47
Show member pathways
12.39 TP53 RAF1 KRAS HRAS EGFR AKT1
48
Show member pathways
12.37 TP53 MYC KRAS EGFR AKT1
49
Show member pathways
12.31 RAF1 KRAS HRAS AKT1
50
Show member pathways
12.31 TP53 RAF1 MYC KRAS HRAS EGFR

GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 9.46 SCGB1A1 MYC LMNTD1 IRAG2
2 multivesicular body lumen GO:0097486 8.96 SFTPC NAPSA
3 alveolar lamellar body GO:0097208 8.62 SFTPC NAPSA

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 TP53 NKX2-1 MYC EGFR CDKN2A AKT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 TP53 RAF1 NKX2-1 MYC HRAS EGFR
3 MAPK cascade GO:0000165 9.77 RAF1 MYC KRAS HRAS EGFR
4 cell cycle arrest GO:0007050 9.73 TP53 MYC HRAS CDKN2A
5 cellular response to drug GO:0035690 9.72 TP53 MYC EGFR
6 positive regulation of epithelial cell proliferation GO:0050679 9.71 MYC HRAS EGFR
7 positive regulation of MAP kinase activity GO:0043406 9.7 KRAS HRAS EGFR
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.69 MYC EGFR AKT1
9 cellular response to epidermal growth factor stimulus GO:0071364 9.63 MYC EGFR AKT1
10 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.57 TP53 EGFR
11 cerebral cortex cell migration GO:0021795 9.56 NKX2-1 EGFR
12 response to isolation stress GO:0035900 9.49 KRAS HRAS
13 Ras protein signal transduction GO:0007265 9.46 TP53 KRAS HRAS CDKN2A
14 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 SYP KRAS HRAS
15 response to UV-A GO:0070141 9.4 EGFR AKT1
16 positive regulation of protein phosphorylation GO:0001934 9.35 RAF1 KRAS HRAS EGFR AKT1
17 positive regulation of gene expression GO:0010628 9.17 TP53 NKX2-1 MYC KRAS HRAS CDKN2A

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.35 RAF1 MYC KRAS HRAS EGFR
2 nitric-oxide synthase regulator activity GO:0030235 9.16 EGFR AKT1
3 enzyme binding GO:0019899 9.02 TP53 RAF1 NKX2-1 EGFR AKT1

Sources for Respiratory System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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