Respiratory System Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RSP004 MIFTS: 29	Respiratory System Benign Neoplasm Categories: Cancer diseases, Respiratory diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Benign neoplasms

Benign neoplasm of middle ear and respiratory system

Benign neoplasm: Respiratory system, unspecified

External Ids:

Disease Ontology ¹² DOID:0050621

ICD10 ³² D14.4

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Summaries for Respiratory System Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. Related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)

#	Related Disease	Score	Top Affiliating Genes
1	pleural lipoma	11.3
2	trachea leiomyoma	11.3
3	signet ring basal cell carcinoma	10.7	KRAS HRAS
4	cobblestone retinal degeneration	10.7	KRAS HRAS
5	villous adenoma	10.6	TP53 KRAS HRAS
6	ovarian clear cell adenofibroma	10.6	NAPSA KRAS
7	hyperplastic polyposis syndrome	10.6	TP53 KRAS
8	vulvar intraepithelial neoplasia	10.6	TP53 CDKN2A
9	trachea carcinoma in situ	10.6	KRAS HRAS CDKN2A
10	endometrial squamous cell carcinoma	10.6	TP53 CDKN2A
11	large intestine adenocarcinoma	10.6	TP53 KRAS HRAS
12	lung meningioma	10.6	SYP NKX2-1
13	female reproductive endometrioid cancer	10.6	TP53 KRAS HRAS
14	ureter adenocarcinoma	10.6	NKX2-1 KRT7
15	adenosquamous lung carcinoma	10.6	KRAS HRAS EGFR
16	acneiform dermatitis	10.6	KRAS HRAS EGFR
17	cervical basaloid squamous cell carcinoma	10.6	KRT7 CDKN2A
18	prostate squamous cell carcinoma	10.6	TP53 HRAS CDKN2A
19	ampulla of vater neoplasm	10.6	SYP KRAS HRAS
20	rare adenocarcinoma of the breast	10.6	TP53 KRAS
21	anal paget's disease	10.6	MLANA KRT7
22	spitz nevus	10.6	TP53 HRAS CDKN2A
23	thyroid carcinoma	10.6	NKX2-1 HRAS AKT1
24	malignant peritoneal mesothelioma	10.6	EGFR CDKN2A
25	paronychia	10.6	KRAS HRAS EGFR
26	pancreatic acinar cell adenocarcinoma	10.6	SYP KRAS HRAS
27	descending colon cancer	10.6	KRAS HRAS
28	squamous cell papilloma	10.6	TP53 HRAS CDKN2A
29	bile duct mucinous adenocarcinoma	10.6	TP53 SYP
30	inverted transitional papilloma	10.6	KRT7 CDKN2A
31	periampullary adenoma	10.6	KRAS HRAS
32	lung non-squamous non-small cell carcinoma	10.6	KRAS HRAS EGFR
33	ovary neuroendocrine neoplasm	10.6	SYP KRT7
34	thyroid tumor	10.6	TP53 KRAS HRAS
35	pancreatic foamy gland adenocarcinoma	10.6	TP53 KRT7
36	adult malignant schwannoma	10.6	TP53 HRAS CDKN2A
37	nasal cavity adenocarcinoma	10.6	KRT7 KRAS HRAS
38	apocrine adenoma	10.6	KRT7 KRAS
39	esophageal basaloid squamous cell carcinoma	10.6	TP53 EGFR
40	duodenal benign neoplasm	10.6	SYP HRAS
41	transverse colon cancer	10.6	KRT7 KRAS HRAS
42	neonatal respiratory failure	10.6	SFTPC SCGB1A1 NKX2-1
43	appendiceal neoplasm	10.6	KRT7 KRAS HRAS
44	rete testis neoplasm	10.6	NKX2-1 KRT7
45	primary cutaneous diffuse large b-cell lymphoma, leg type	10.6	MYC CDKN2A
46	vulvar eccrine porocarcinoma	10.6	SYP CDKN2A
47	myoepithelial carcinoma	10.6	TP53 KRT7 HRAS
48	rete testis adenocarcinoma	10.5	NKX2-1 KRT7
49	duodenum adenocarcinoma	10.5	KRT7 KRAS HRAS
50	bile duct cysts	10.5	KRT7 KRAS HRAS

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:

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Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	9.84	EGFR HRAS KRAS
2	Decreased viability	GR00055-A-2	9.84	EGFR HRAS KRAS
3	Decreased viability	GR00055-A-3	9.84	KRAS
4	Decreased viability	GR00106-A-0	9.84	KRAS
5	Decreased viability	GR00221-A-1	9.84	AKT1 CDKN2A EGFR HRAS KRAS MYC
6	Decreased viability	GR00221-A-2	9.84	AKT1 HRAS KRAS RAF1
7	Decreased viability	GR00221-A-3	9.84	AKT1 CDKN2A HRAS MYC
8	Decreased viability	GR00221-A-4	9.84	AKT1 CDKN2A EGFR
9	Decreased viability	GR00249-S	9.84	AKT1 MYC
10	Decreased viability	GR00301-A	9.84	KRAS RAF1
11	Decreased viability	GR00381-A-1	9.84	KRAS
12	Decreased viability	GR00402-S-2	9.84	MYC RAF1

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.13	AKT1 CDKN2A EGFR HRAS KRAS MYC
2	endocrine/exocrine gland	MP:0005379	10.1	AKT1 CDKN2A EGFR HRAS KRAS MYC
3	neoplasm	MP:0002006	10.1	AKT1 CDKN2A CFAP94 EGFR HRAS KRAS
4	integument	MP:0010771	10.07	AKT1 CDKN2A EGFR HRAS IRAG2 KRAS
5	no phenotypic analysis	MP:0003012	9.96	CDKN2A EGFR HRAS KRAS MLANA MYC
6	normal	MP:0002873	9.85	AKT1 EGFR HRAS KRAS MYC NKX2-1
7	pigmentation	MP:0001186	9.43	CDKN2A EGFR KRAS MLANA MYC TP53
8	respiratory system	MP:0005388	9.32	AKT1 CDKN2A EGFR HRAS KRAS NKX2-1

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Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

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Genetic Tests for Respiratory System Benign Neoplasm

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Anatomical Context for Respiratory System Benign Neoplasm

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Publications for Respiratory System Benign Neoplasm

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Genes for Respiratory System Benign Neoplasm

Genes related to Respiratory System Benign Neoplasm (0 elite genes):

(show all 32)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR30C1	MicroRNA 30c-1	RNA Gene	8.53	DISEASES inferred ¹⁵ ¹⁵
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7.32	DISEASES inferred ¹⁵
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.24	DISEASES inferred ¹⁵
4	MIR362	MicroRNA 362	RNA Gene	7.19	DISEASES inferred ¹⁵ ¹⁵
5	NKX2-1	NK2 Homeobox 1	Protein Coding	7.16	DISEASES inferred ¹⁵
6	CFAP94	Cilia And Flagella Associated Protein 94	Protein Coding	6.94	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	6.91	DISEASES inferred ¹⁵
8	LMNTD1	Lamin Tail Domain Containing 1	Protein Coding	6.69	DISEASES inferred ¹⁵
9	IRAG2	Inositol 1,4,5-Triphosphate Receptor Associated 2	Protein Coding	6.66	DISEASES inferred ¹⁵
10	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	6.57	DISEASES inferred ¹⁵
11	SFTPC	Surfactant Protein C	Protein Coding	6.45	DISEASES inferred ¹⁵
12	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.42	DISEASES inferred ¹⁵
13	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.24	DISEASES inferred ¹⁵
14	SYP	Synaptophysin	Protein Coding	6.03	DISEASES inferred ¹⁵
15	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	5.98	DISEASES inferred ¹⁵
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.97	DISEASES inferred ¹⁵
17	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.9	DISEASES inferred ¹⁵
18	KRT7	Keratin 7	Protein Coding	5.85	DISEASES inferred ¹⁵
19	MLANA	Melan-A	Protein Coding	5.81	DISEASES inferred ¹⁵
20	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5.78	DISEASES inferred ¹⁵
21	SERPINB3	Serpin Family B Member 3	Protein Coding	5.77	DISEASES inferred ¹⁵
22	CCND1	Cyclin D1	Protein Coding	5.76	DISEASES inferred ¹⁵
23	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.67	DISEASES inferred ¹⁵
24	CHGA	Chromogranin A	Protein Coding	5.65	DISEASES inferred ¹⁵
25	CD34	CD34 Molecule	Protein Coding	5.58	DISEASES inferred ¹⁵
26	CTNNB1	Catenin Beta 1	Protein Coding	5.55	DISEASES inferred ¹⁵
27	KRT5	Keratin 5	Protein Coding	5.5	DISEASES inferred ¹⁵
28	ENO2	Enolase 2	Protein Coding	5.49	DISEASES inferred ¹⁵
29	ACTB	Actin Beta	Protein Coding	5.47	DISEASES inferred ¹⁵
30	FOXN3-AS2	FOXN3 Antisense RNA 2	RNA Gene	5.45	DISEASES inferred ¹⁵
31	C18orf54	Chromosome 18 Open Reading Frame 54	Protein Coding	5.45	DISEASES inferred ¹⁵
32	CDH1	Cadherin 1	Protein Coding	5.43	DISEASES inferred ¹⁵

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Variations for Respiratory System Benign Neoplasm

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Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

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Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 125)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.45	TP53 RAF1 MYC KRAS HRAS EGFR
2	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.31	TP53 RAF1 MYC KRAS HRAS EGFR
3	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	13.16	TP53 RAF1 KRAS HRAS EGFR AKT1
4	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.16	TP53 RAF1 MYC KRAS HRAS EGFR
5	G-Beta Gamma Signaling ⁶³ Show member pathways CRHR Pathway ⁶³ GHRH Signaling ⁶³ Hedgehog Signaling in Mammals ⁶³ Relaxin Pathway ⁶³ Signaling in Gap Junctions ⁶³	13.13	RAF1 KRAS HRAS EGFR CDKN2A AKT1
6	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.09	TP53 RAF1 MYC KRAS HRAS EGFR
7	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13.01	TP53 RAF1 MYC KRAS HRAS EGFR
8	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.95	TP53 RAF1 MYC KRAS HRAS EGFR
9	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.93	RAF1 KRAS HRAS EGFR AKT1
10	Pathways in cancer ³⁶	12.9	TP53 RAF1 MYC KRAS HRAS EGFR
11	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipocytokines and Insulin Signaling ⁶⁴ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²²	12.87	RAF1 MYC KRAS HRAS AKT1
12	MAPK signaling pathway ³⁶ ¹	12.86	TP53 RAF1 MYC KRAS HRAS EGFR
13	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.83	RAF1 KRAS HRAS EGFR AKT1
14	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.82	TP53 KRAS HRAS EGFR AKT1
15	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.81	TP53 RAF1 KRAS HRAS AKT1
16	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.8	TP53 RAF1 MYC KRAS HRAS CDKN2A
17	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.78	TP53 RAF1 MYC KRAS HRAS EGFR
18	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.77	RAF1 KRAS HRAS EGFR AKT1
19	G-AlphaQ Signaling ⁶³ Show member pathways G-AlphaI Signaling ⁶³ Thrombin Signaling ⁶³	12.77	RAF1 KRAS HRAS EGFR AKT1
20	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.77	TP53 RAF1 KRAS HRAS EGFR AKT1
21	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.76	TP53 RAF1 KRAS HRAS EGFR CDKN2A
22	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.75	RAF1 KRAS HRAS EGFR AKT1
23	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.71	RAF1 KRAS HRAS EGFR AKT1
24	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.7	TP53 RAF1 MYC KRAS HRAS EGFR
25	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.69	TP53 MYC KRAS HRAS EGFR AKT1
26	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.6	RAF1 MYC KRAS HRAS AKT1
27	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling ⁶⁴	12.6	TP53 RAF1 KRAS HRAS EGFR AKT1
28	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.57	RAF1 MYC KRAS HRAS EGFR AKT1
29	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.56	TP53 KRAS HRAS EGFR AKT1
30	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.56	TP53 RAF1 MYC KRAS HRAS EGFR
31	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.53	RAF1 KRAS HRAS EGFR AKT1
32	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.52	RAF1 MYC KRAS HRAS AKT1
33	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.52	RAF1 KRAS HRAS EGFR AKT1
34	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.51	TP53 RAF1 MYC HRAS AKT1
35	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	12.49	RAF1 KRAS HRAS AKT1
36	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶³	12.49	RAF1 KRAS HRAS AKT1
37	MicroRNAs in cancer ³⁶	12.46	TP53 RAF1 MYC MIR30C1 KRAS HRAS
38	Human T-cell leukemia virus 1 infection ³⁶	12.44	TP53 MYC KRAS HRAS CDKN2A AKT1
39	CNTF Signaling ⁶³ Show member pathways FLT3 Signaling ⁶³ IL-3 Pathway ⁶³ Nur77-Induced AICD in Macrophage ⁶³ OSM Pathway ⁶³	12.43	RAF1 KRAS HRAS AKT1
40	Development A3 receptor signaling ²² Show member pathways Development A1 receptor signaling ²² G-protein signaling G-Protein alpha-q signaling cascades ²²	12.42	RAF1 MYC HRAS AKT1
41	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.42	RAF1 HRAS EGFR AKT1
42	Translation Non-genomic (rapid) action of Androgen Receptor ²² Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²²	12.42	TP53 RAF1 HRAS EGFR AKT1
43	Signaling by ERBB2 ⁶⁵ Show member pathways Downregulation of ERBB2 signaling ⁶⁵ Downregulation of ERBB2-ERBB3 signaling ⁶⁵ ERBB2 Activates PTK6 Signaling ⁶⁵ ERBB2 Regulates Cell Motility ⁶⁵ GRB2 events in ERBB2 signaling ⁶⁵ GRB7 events in ERBB2 signaling ⁶⁵ PI3K events in ERBB2 signaling ⁶⁵ PI3K events in ERBB4 signaling ⁶⁵ PLCG1 events in ERBB2 signaling ⁶⁵ SHC1 events in ERBB2 signaling ⁶⁵ SHC1 events in ERBB4 signaling ⁶⁵	12.41	KRAS HRAS EGFR AKT1
44	Salmonella infection (KEGG) ³⁶	12.4	RAF1 MYC HRAS AKT1
45	Viral carcinogenesis ³⁶	12.4	TP53 KRAS HRAS CDKN2A
46	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶³ ErbB receptor signaling network ¹	12.4	RAF1 MYC KRAS HRAS EGFR AKT1
47	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.39	TP53 RAF1 KRAS HRAS EGFR AKT1
48	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.37	TP53 MYC KRAS EGFR AKT1
49	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.31	RAF1 KRAS HRAS AKT1
50	MAPK Signaling: Mitogens ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.31	TP53 RAF1 MYC KRAS HRAS EGFR

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GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear envelope	GO:0005635	9.46	SCGB1A1 MYC LMNTD1 IRAG2
2	multivesicular body lumen	GO:0097486	8.96	SFTPC NAPSA
3	alveolar lamellar body	GO:0097208	8.62	SFTPC NAPSA

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.95	TP53 NKX2-1 MYC EGFR CDKN2A AKT1
2	positive regulation of transcription by RNA polymerase II	GO:0045944	9.92	TP53 RAF1 NKX2-1 MYC HRAS EGFR
3	MAPK cascade	GO:0000165	9.77	RAF1 MYC KRAS HRAS EGFR
4	cell cycle arrest	GO:0007050	9.73	TP53 MYC HRAS CDKN2A
5	cellular response to drug	GO:0035690	9.72	TP53 MYC EGFR
6	positive regulation of epithelial cell proliferation	GO:0050679	9.71	MYC HRAS EGFR
7	positive regulation of MAP kinase activity	GO:0043406	9.7	KRAS HRAS EGFR
8	positive regulation of smooth muscle cell proliferation	GO:0048661	9.69	MYC EGFR AKT1
9	cellular response to epidermal growth factor stimulus	GO:0071364	9.63	MYC EGFR AKT1
10	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.57	TP53 EGFR
11	cerebral cortex cell migration	GO:0021795	9.56	NKX2-1 EGFR
12	response to isolation stress	GO:0035900	9.49	KRAS HRAS
13	Ras protein signal transduction	GO:0007265	9.46	TP53 KRAS HRAS CDKN2A
14	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.43	SYP KRAS HRAS
15	response to UV-A	GO:0070141	9.4	EGFR AKT1
16	positive regulation of protein phosphorylation	GO:0001934	9.35	RAF1 KRAS HRAS EGFR AKT1
17	positive regulation of gene expression	GO:0010628	9.17	TP53 NKX2-1 MYC KRAS HRAS CDKN2A

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex binding	GO:0044877	9.35	RAF1 MYC KRAS HRAS EGFR
2	nitric-oxide synthase regulator activity	GO:0030235	9.16	EGFR AKT1
3	enzyme binding	GO:0019899	9.02	TP53 RAF1 NKX2-1 EGFR AKT1

Sources

Sources for Respiratory System Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia