MCID: RSP004
MIFTS: 32

Respiratory System Benign Neoplasm

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050621
ICD10 32 D14.4

Summaries for Respiratory System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include lung, breast and thyroid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 pleural lipoma 11.3
2 trachea leiomyoma 11.3
3 signet ring basal cell carcinoma 10.7 KRAS HRAS
4 nasal cavity adenocarcinoma 10.6 KRAS HRAS
5 hyperplastic polyposis syndrome 10.6 TP53 KRAS
6 wolffian duct adenocarcinoma 10.6 TP53 KRAS HRAS
7 periampullary adenoma 10.6 KRAS HRAS
8 esophageal leukoplakia 10.6 TP53 CCND1
9 tumor of exocrine pancreas 10.6 TP53 KRAS HRAS
10 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
11 appendix disease 10.6 TP53 KRAS HRAS
12 appendix cancer 10.6 TP53 KRAS HRAS
13 breast squamous cell carcinoma 10.6 TP53 HRAS
14 chromosome 14q11-q22 deletion syndrome 10.6 NKX2-1 HRAS
15 trachea carcinoma in situ 10.6 KRAS HRAS CDKN2A
16 lung meningioma 10.6 SYP NKX2-1
17 female reproductive endometrioid cancer 10.6 TP53 KRAS HRAS
18 cystadenocarcinoma 10.6 TP53 HRAS AKT1
19 endometrial transitional cell carcinoma 10.6 SYP CDKN2A
20 duodenum disease 10.6 TP53 KRAS HRAS
21 small cell carcinoma of the bladder 10.6 SYP NKX2-1
22 acneiform dermatitis 10.6 KRAS HRAS EGFR
23 papillary serous adenocarcinoma 10.6 TP53 NKX2-1 KRAS
24 ampulla of vater neoplasm 10.6 SYP KRAS HRAS
25 rare adenocarcinoma of the breast 10.6 TP53 KRAS
26 spitz nevus 10.6 TP53 HRAS CDKN2A
27 signet ring cell adenocarcinoma 10.6 TP53 KRAS HRAS
28 laryngeal neuroendocrine tumor 10.6 TP53 SYP
29 appendix adenocarcinoma 10.6 SYP KRAS HRAS
30 malignant peritoneal mesothelioma 10.6 EGFR CDKN2A
31 bile duct mucinous adenocarcinoma 10.6 TP53 SYP
32 paronychia 10.6 KRAS HRAS EGFR
33 pancreatic acinar cell adenocarcinoma 10.5 SYP KRAS HRAS
34 ovarian seromucinous carcinoma 10.5 TP53 CDKN2A
35 anal canal paget's disease 10.5 MLANA CDKN2A
36 thyroid tumor 10.5 TP53 KRAS HRAS
37 esophageal basaloid squamous cell carcinoma 10.5 TP53 EGFR
38 adult malignant schwannoma 10.5 TP53 HRAS CDKN2A
39 pancreatic foamy gland adenocarcinoma 10.5 TP53 CCND1
40 duodenal benign neoplasm 10.5 SYP HRAS
41 papillary adenocarcinoma 10.5 TP53 NKX2-1 KRAS
42 vulvar eccrine porocarcinoma 10.5 SYP CDKN2A
43 primary cutaneous diffuse large b-cell lymphoma, leg type 10.5 MYC CDKN2A
44 malignant anus melanoma 10.5 MLANA HRAS
45 plexiform neurofibroma 10.5 TP53 HRAS CDKN2A
46 chordoid glioma 10.5 TP53 SYP NKX2-1
47 eccrine papillary adenoma 10.5 KRAS HRAS
48 anal carcinoma in situ 10.5 TP53 MYC
49 small intestine cancer 10.5 TP53 KRAS HRAS
50 pleomorphic carcinoma 10.5 TP53 NKX2-1 EGFR

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:



Diseases related to Respiratory System Benign Neoplasm

Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.17 EGFR HRAS KRAS
2 Decreased viability GR00106-A-0 10.17 KRAS
3 Decreased viability GR00221-A-1 10.17 AKT1 CDKN2A EGFR HRAS KRAS MYC
4 Decreased viability GR00221-A-2 10.17 AKT1 HRAS KRAS RAF1
5 Decreased viability GR00221-A-3 10.17 AKT1 CDKN2A HRAS MYC
6 Decreased viability GR00221-A-4 10.17 AKT1 CDKN2A EGFR
7 Decreased viability GR00231-A 10.17 RAF1
8 Decreased viability GR00301-A 10.17 KRAS RAF1
9 Decreased viability GR00381-A-1 10.17 KRAS
10 Decreased viability GR00402-S-2 10.17 AKT1 CDKN2A EGFR HRAS KRAS MYC
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 AKT1 CASC1 CDKN2A LMNTD1 RAF1 TP53
12 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 AKT1 CASC1 CCND1 CDKN2A LMNTD1 MYC

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
2 growth/size/body region MP:0005378 10.23 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
3 endocrine/exocrine gland MP:0005379 10.22 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
4 neoplasm MP:0002006 10.22 AKT1 CASC1 CCND1 CDKN2A EGFR HRAS
5 integument MP:0010771 10.17 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
6 nervous system MP:0003631 10.11 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
7 digestive/alimentary MP:0005381 10.1 CCND1 CDKN2A EGFR HRAS KRAS MYC
8 craniofacial MP:0005382 10.05 CCND1 EGFR HRAS KRAS MYC RAF1
9 no phenotypic analysis MP:0003012 10.02 CDKN2A EGFR HRAS KRAS MLANA MYC
10 normal MP:0002873 10 AKT1 CCND1 EGFR HRAS KRAS MYC
11 respiratory system MP:0005388 9.7 AKT1 CCND1 CDKN2A EGFR HRAS KRAS
12 pigmentation MP:0001186 9.63 CDKN2A EGFR KRAS MLANA MYC TP53
13 skeleton MP:0005390 9.32 AKT1 CCND1 CDKN2A EGFR HRAS KRAS

Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

Genetic Tests for Respiratory System Benign Neoplasm

Anatomical Context for Respiratory System Benign Neoplasm

MalaCards organs/tissues related to Respiratory System Benign Neoplasm:

40
Lung, Breast, Thyroid, Skin, Ovary, B Cells, Bone

Publications for Respiratory System Benign Neoplasm

Variations for Respiratory System Benign Neoplasm

Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 TP53 RAF1 MYC KRAS HRAS EGFR
2
Show member pathways
13.82 TP53 RAF1 MYC KRAS HRAS EGFR
3
Show member pathways
13.49 TP53 RAF1 MYC KRAS HRAS EGFR
4
Show member pathways
13.34 TP53 RAF1 MYC KRAS HRAS EGFR
5
Show member pathways
13.24 TP53 RAF1 MYC KRAS HRAS EGFR
6
Show member pathways
13.18 TP53 RAF1 KRAS HRAS EGFR AKT1
7
Show member pathways
13.15 RAF1 KRAS HRAS EGFR CDKN2A AKT1
8
Show member pathways
13.08 TP53 RAF1 MYC KRAS HRAS EGFR
9
Show member pathways
13.07 TP53 RAF1 KRAS HRAS EGFR AKT1
10
Show member pathways
13.04 TP53 RAF1 MYC KRAS HRAS EGFR
11
Show member pathways
13.03 RAF1 KRAS HRAS EGFR CDKN2A CCND1
12
Show member pathways
13.02 RAF1 KRAS HRAS EGFR CCND1 AKT1
13
Show member pathways
12.95 RAF1 KRAS HRAS EGFR AKT1
14
Show member pathways
12.92 TP53 RAF1 MYC CCND1 AKT1
15
Show member pathways
12.92 TP53 RAF1 MYC KRAS HRAS CDKN2A
16
Show member pathways
12.92 TP53 RAF1 MYC KRAS HRAS EGFR
17
Show member pathways
12.91 RAF1 MYC KRAS HRAS CCND1 AKT1
18 12.89 TP53 RAF1 MYC KRAS HRAS EGFR
19 12.87 TP53 RAF1 MYC KRAS HRAS EGFR
20
Show member pathways
12.85 RAF1 KRAS HRAS EGFR AKT1
21
Show member pathways
12.84 TP53 KRAS HRAS EGFR AKT1
22
Show member pathways
12.83 TP53 RAF1 KRAS HRAS AKT1
23
Show member pathways
12.8 TP53 RAF1 KRAS HRAS EGFR AKT1
24
Show member pathways
12.79 RAF1 KRAS HRAS EGFR AKT1
25
Show member pathways
12.79 RAF1 KRAS HRAS EGFR AKT1
26
Show member pathways
12.78 TP53 RAF1 MYC KRAS HRAS EGFR
27
Show member pathways
12.77 RAF1 KRAS HRAS EGFR CCND1 AKT1
28
Show member pathways
12.76 TP53 RAF1 KRAS HRAS EGFR CDKN2A
29
Show member pathways
12.73 RAF1 KRAS HRAS EGFR AKT1
30
Show member pathways
12.72 RAF1 NKX2-1 HRAS CCND1 AKT1
31
Show member pathways
12.72 TP53 MYC KRAS HRAS EGFR AKT1
32
Show member pathways
12.7 TP53 MYC CDKN2A CCND1 AKT1
33
Show member pathways
12.69 TP53 RAF1 MYC KRAS HRAS EGFR
34
Show member pathways
12.64 TP53 RAF1 MYC KRAS HRAS EGFR
35
Show member pathways
12.63 TP53 RAF1 KRAS HRAS EGFR AKT1
36
Show member pathways
12.62 RAF1 KRAS HRAS EGFR CCND1
37
Show member pathways
12.6 RAF1 MYC KRAS HRAS CCND1 AKT1
38
Show member pathways
12.58 TP53 KRAS HRAS EGFR AKT1
39
Show member pathways
12.57 TP53 RAF1 HRAS CCND1 AKT1
40
Show member pathways
12.55 RAF1 KRAS HRAS EGFR AKT1
41
Show member pathways
12.55 RAF1 MYC KRAS HRAS AKT1
42
Show member pathways
12.54 RAF1 KRAS HRAS EGFR AKT1
43
Show member pathways
12.51 RAF1 KRAS HRAS AKT1
44
Show member pathways
12.51 TP53 RAF1 MYC HRAS CCND1 AKT1
45
Show member pathways
12.5 RAF1 KRAS HRAS AKT1
46
Show member pathways
12.48 TP53 MYC CDKN2A CCND1
47
Show member pathways
12.48 RAF1 MYC HRAS EGFR CCND1 AKT1
48 12.47 TP53 MYC CDKN2A CCND1
49 12.47 TP53 RAF1 MYC MIR30C1 KRAS HRAS
50
Show member pathways
12.46 TP53 RAF1 CDKN2A CCND1

GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 8.92 SCGB1A1 MYC LRMP LMNTD1

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.02 TP53 NKX2-1 MYC EGFR CDKN2A AKT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 TP53 RAF1 NKX2-1 MYC HRAS EGFR
3 positive regulation of cell proliferation GO:0008284 9.97 MYC KRAS HRAS EGFR CCND1 AKT1
4 cell proliferation GO:0008283 9.9 TP53 LMNTD1 EGFR AKT1
5 cytokine-mediated signaling pathway GO:0019221 9.88 TP53 MYC KRAS CCND1 AKT1
6 MAPK cascade GO:0000165 9.83 RAF1 MYC KRAS HRAS EGFR
7 cell cycle arrest GO:0007050 9.81 TP53 MYC HRAS CDKN2A
8 liver development GO:0001889 9.8 KRAS EGFR CCND1
9 cellular response to drug GO:0035690 9.77 TP53 MYC EGFR
10 response to glucocorticoid GO:0051384 9.76 SCGB1A1 KRAS CCND1
11 positive regulation of MAP kinase activity GO:0043406 9.74 KRAS HRAS EGFR
12 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.71 EGFR CCND1 AKT1
13 cellular response to reactive oxygen species GO:0034614 9.7 TP53 EGFR AKT1
14 positive regulation of gene expression GO:0010628 9.7 TP53 NKX2-1 MYC KRAS HRAS CDKN2A
15 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.63 EGFR CCND1 AKT1
16 Leydig cell differentiation GO:0033327 9.62 NKX2-1 CCND1
17 Ras protein signal transduction GO:0007265 9.62 TP53 KRAS HRAS CDKN2A
18 cerebral cortex cell migration GO:0021795 9.61 NKX2-1 EGFR
19 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.61 TP53 EGFR
20 mitotic G1 DNA damage checkpoint GO:0031571 9.58 TP53 CCND1
21 response to isolation stress GO:0035900 9.56 KRAS HRAS
22 positive regulation of epithelial cell proliferation GO:0050679 9.56 MYC HRAS EGFR CCND1
23 regulation of long-term neuronal synaptic plasticity GO:0048169 9.54 SYP KRAS HRAS
24 positive regulation of protein phosphorylation GO:0001934 9.43 RAF1 KRAS HRAS EGFR CCND1 AKT1
25 response to UV-A GO:0070141 8.8 EGFR CCND1 AKT1

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 TP53 EGFR CDKN2A CCND1 AKT1
2 enzyme binding GO:0019899 9.1 TP53 RAF1 NKX2-1 EGFR CCND1 AKT1
3 nitric-oxide synthase regulator activity GO:0030235 8.96 EGFR AKT1

Sources for Respiratory System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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