Respiratory System Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RSP004 MIFTS: 28	Respiratory System Benign Neoplasm Categories: Cancer diseases, Respiratory diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Respiratory System Benign Neoplasm

MalaCards integrated aliases for Respiratory System Benign Neoplasm:

Name: Respiratory System Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Benign neoplasms

Benign neoplasm of middle ear and respiratory system

Benign neoplasm: Respiratory system, unspecified

External Ids:

Disease Ontology ¹² DOID:0050621

ICD10 ³² D14.4

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Summaries for Respiratory System Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.

MalaCards based summary : Respiratory System Benign Neoplasm is related to pleural lipoma and trachea leiomyoma. An important gene associated with Respiratory System Benign Neoplasm is MIR30C1 (MicroRNA 30c-1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and PI3K-Akt signaling pathway. Related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Respiratory System Benign Neoplasm

Diseases related to Respiratory System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)

#	Related Disease	Score	Top Affiliating Genes
1	pleural lipoma	11.2
2	trachea leiomyoma	11.2
3	hepatic flexure cancer	10.5	KRAS HRAS
4	signet ring basal cell carcinoma	10.5	KRAS HRAS
5	cobblestone retinal degeneration	10.5	KRAS HRAS
6	immature teratoma of ovary	10.5	KRAS HRAS
7	descending colon cancer	10.5	KRAS HRAS
8	ovarian clear cell adenofibroma	10.5	NAPSA KRAS
9	trachea carcinoma in situ	10.4	KRAS HRAS CDKN2A
10	large intestine adenocarcinoma	10.4	TP53 KRAS HRAS
11	vulvar intraepithelial neoplasia	10.4	TP53 CDKN2A
12	periampullary adenoma	10.4	KRAS HRAS
13	acneiform dermatitis	10.4	KRAS HRAS EGFR
14	adenosquamous lung carcinoma	10.4	KRAS HRAS EGFR
15	anal carcinoma in situ	10.4	TP53 MYC
16	spitz nevus	10.4	TP53 HRAS CDKN2A
17	paronychia	10.4	KRAS HRAS EGFR
18	ethmoid sinus adenocarcinoma	10.4	KRAS HRAS EGFR
19	squamous cell papilloma	10.4	TP53 HRAS CDKN2A
20	thymus basaloid carcinoma	10.4	SYP NKX2-1
21	lung meningioma	10.4	SYP NKX2-1
22	ureter adenocarcinoma	10.4	NKX2-1 KRT7
23	adult malignant schwannoma	10.4	TP53 HRAS CDKN2A
24	oculoectodermal syndrome	10.4	KRAS HRAS AKT1
25	lung non-squamous non-small cell carcinoma	10.4	KRAS HRAS EGFR
26	malignant peritoneal mesothelioma	10.4	EGFR CDKN2A
27	cervical basaloid squamous cell carcinoma	10.4	KRT7 CDKN2A
28	ampulla of vater neoplasm	10.4	SYP KRAS HRAS
29	alveoli adenoma	10.4	SFTPC SCGB1A1 NKX2-1
30	bronchial benign neoplasm	10.4	SFTPC SCGB1A1 NKX2-1
31	prostate squamous cell carcinoma	10.4	TP53 HRAS CDKN2A
32	neonatal respiratory failure	10.4	SFTPC SCGB1A1 NKX2-1
33	esophageal basaloid squamous cell carcinoma	10.4	TP53 EGFR
34	nodular malignant melanoma	10.4	TP53 HRAS CDKN2A
35	pancreatic acinar cell adenocarcinoma	10.4	SYP KRAS HRAS
36	sarcomatoid transitional cell carcinoma	10.4	TP53 SYP
37	bile duct mucinous adenocarcinoma	10.4	TP53 SYP
38	inverted transitional papilloma	10.4	KRT7 CDKN2A
39	pancreatic foamy gland adenocarcinoma	10.4	TP53 KRT7
40	human papillomavirus infectious disease	10.4	TP53 CDKN2A
41	transverse colon cancer	10.4	KRT7 KRAS HRAS
42	appendiceal neoplasm	10.4	KRT7 KRAS HRAS
43	gallbladder benign neoplasm	10.4	KRT7 KRAS HRAS
44	carotid body cancer	10.4	SYP NKX2-1
45	wolffian duct adenocarcinoma	10.4	KRT7 KRAS HRAS
46	myoepithelial carcinoma	10.4	TP53 KRT7 HRAS
47	barrett's adenocarcinoma	10.4	TP53 KRAS CDKN2A
48	esophagus verrucous carcinoma	10.4	TP53 EGFR CDKN2A
49	anal canal paget's disease	10.4	KRT7 CDKN2A
50	verrucous carcinoma	10.4	TP53 EGFR CDKN2A

Graphical network of the top 20 diseases related to Respiratory System Benign Neoplasm:

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Symptoms & Phenotypes for Respiratory System Benign Neoplasm

GenomeRNAi Phenotypes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	9.78	EGFR HRAS KRAS
2	Decreased viability	GR00055-A-2	9.78	EGFR HRAS KRAS
3	Decreased viability	GR00055-A-3	9.78	KRAS
4	Decreased viability	GR00106-A-0	9.78	KRAS
5	Decreased viability	GR00221-A-1	9.78	AKT1 CDKN2A EGFR HRAS KRAS MYC
6	Decreased viability	GR00221-A-2	9.78	AKT1 HRAS KRAS
7	Decreased viability	GR00221-A-3	9.78	AKT1 CDKN2A HRAS MYC
8	Decreased viability	GR00221-A-4	9.78	AKT1 CDKN2A EGFR
9	Decreased viability	GR00249-S	9.78	AKT1 MYC
10	Decreased viability	GR00301-A	9.78	KRAS
11	Decreased viability	GR00381-A-1	9.78	KRAS
12	Decreased viability	GR00402-S-2	9.78	MYC

MGI Mouse Phenotypes related to Respiratory System Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	10	AKT1 CDKN2A DNAI7 EGFR HRAS KRAS
2	no phenotypic analysis	MP:0003012	9.76	CDKN2A EGFR HRAS KRAS MYC NKX2-1
3	normal	MP:0002873	9.61	AKT1 EGFR HRAS KRAS MYC NKX2-1
4	respiratory system	MP:0005388	9.28	AKT1 CDKN2A EGFR HRAS KRAS NKX2-1

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Drugs & Therapeutics for Respiratory System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Respiratory System Benign Neoplasm

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Genetic Tests for Respiratory System Benign Neoplasm

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Anatomical Context for Respiratory System Benign Neoplasm

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Publications for Respiratory System Benign Neoplasm

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Genes for Respiratory System Benign Neoplasm

Genes related to Respiratory System Benign Neoplasm (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR30C1	MicroRNA 30c-1	RNA Gene	8.44	DISEASES inferred ¹⁵ ¹⁵
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7.24	DISEASES inferred ¹⁵
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.22	DISEASES inferred ¹⁵
4	NKX2-1	NK2 Homeobox 1	Protein Coding	7.08	DISEASES inferred ¹⁵
5	MIR362	MicroRNA 362	RNA Gene	7.04	DISEASES inferred ¹⁵ ¹⁵
6	DNAI7	Dynein Axonemal Intermediate Chain 7	Protein Coding	6.89	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	6.85	DISEASES inferred ¹⁵
8	H2AC18	H2A Clustered Histone 18	Protein Coding	6.73	DISEASES inferred ¹⁵ ¹⁵
9	LMNTD1	Lamin Tail Domain Containing 1	Protein Coding	6.66	DISEASES inferred ¹⁵
10	IRAG2	Inositol 1,4,5-Triphosphate Receptor Associated 2	Protein Coding	6.64	DISEASES inferred ¹⁵
11	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	6.56	DISEASES inferred ¹⁵
12	SFTPC	Surfactant Protein C	Protein Coding	6.41	DISEASES inferred ¹⁵
13	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.34	DISEASES inferred ¹⁵
14	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.16	DISEASES inferred ¹⁵
15	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.93	DISEASES inferred ¹⁵
16	C18orf54	Chromosome 18 Open Reading Frame 54	Protein Coding	5.91	DISEASES inferred ¹⁵
17	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	5.87	DISEASES inferred ¹⁵
18	SYP	Synaptophysin	Protein Coding	5.87	DISEASES inferred ¹⁵
19	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.85	DISEASES inferred ¹⁵
20	KRT7	Keratin 7	Protein Coding	5.74	DISEASES inferred ¹⁵
21	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5.73	DISEASES inferred ¹⁵
22	MLANA	Melan-A	Protein Coding	5.72	DISEASES inferred ¹⁵
23	CCND1	Cyclin D1	Protein Coding	5.7	DISEASES inferred ¹⁵
24	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.64	DISEASES inferred ¹⁵
25	CHGA	Chromogranin A	Protein Coding	5.52	DISEASES inferred ¹⁵
26	CTNNB1	Catenin Beta 1	Protein Coding	5.49	DISEASES inferred ¹⁵
27	CD34	CD34 Molecule	Protein Coding	5.46	DISEASES inferred ¹⁵
28	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	5.44	DISEASES inferred ¹⁵
29	FOXN3-AS2	FOXN3 Antisense RNA 2	RNA Gene	5.42	DISEASES inferred ¹⁵
30	ACTB	Actin Beta	Protein Coding	5.42	DISEASES inferred ¹⁵
31	CDH1	Cadherin 1	Protein Coding	5.37	DISEASES inferred ¹⁵

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Variations for Respiratory System Benign Neoplasm

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Expression for Respiratory System Benign Neoplasm

Search GEO for disease gene expression data for Respiratory System Benign Neoplasm.

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Pathways for Respiratory System Benign Neoplasm

Pathways related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 78)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.1	TP53 MYC KRAS HRAS EGFR AKT1
2	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.03	TP53 MYC KRAS HRAS EGFR AKT1
3	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.98	TP53 MYC KRAS HRAS EGFR CDKN2A
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.88	TP53 MYC KRAS HRAS EGFR CDKN2A
5	Pathways in cancer ³⁶	12.82	TP53 MYC KRAS HRAS EGFR CDKN2A
6	MAPK signaling pathway ³⁶ ¹	12.8	TP53 MYC KRAS HRAS EGFR AKT1
7	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.76	TP53 KRAS HRAS EGFR AKT1
8	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²³ Apoptosis Signaling Pathways ⁶⁴	12.75	TP53 MYC KRAS HRAS CDKN2A AKT1
9	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.72	TP53 KRAS HRAS EGFR CDKN2A AKT1
10	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.71	TP53 KRAS HRAS EGFR AKT1
11	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.71	TP53 MYC KRAS HRAS EGFR CDKN2A
12	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.67	TP53 MYC KRAS HRAS EGFR AKT1
13	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.63	TP53 MYC KRAS HRAS EGFR AKT1
14	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.55	TP53 KRAS HRAS EGFR AKT1
15	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.49	TP53 KRAS HRAS EGFR AKT1
16	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.48	TP53 MYC KRAS HRAS EGFR AKT1
17	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.45	MYC HRAS EGFR AKT1
18	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.44	MYC KRAS HRAS AKT1
19	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.44	KRAS HRAS EGFR AKT1
20	Development IGF-1 receptor signaling ²³ Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²³ Signal transduction AKT signaling ²³	12.43	TP53 MYC HRAS AKT1
21	MicroRNAs in cancer ³⁶	12.4	TP53 MYC MIR30C1 KRAS HRAS EGFR
22	Development ERBB-family signaling ²³ Show member pathways Development EGFR signaling pathway ²³ EGF Pathway ⁶³ ErbB receptor signaling network ¹ GRB7 events in ERBB2 signaling ⁶⁵ PLCG1 events in ERBB2 signaling ⁶⁵	12.37	MYC KRAS HRAS EGFR AKT1
23	Translation Non-genomic (rapid) action of Androgen Receptor ²³ Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²³	12.36	TP53 HRAS EGFR AKT1
24	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²³ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²³ MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.35	TP53 KRAS HRAS EGFR AKT1
25	Viral carcinogenesis ³⁶	12.34	TP53 KRAS HRAS CDKN2A
26	Signaling by ERBB2 ⁶⁵ Show member pathways Downregulation of ERBB2 signaling ⁶⁵ Downregulation of ERBB2-ERBB3 signaling ⁶⁵ ERBB2 Activates PTK6 Signaling ⁶⁵ ERBB2 Regulates Cell Motility ⁶⁵ GRB2 events in ERBB2 signaling ⁶⁵ PI3K events in ERBB2 signaling ⁶⁵ PI3K events in ERBB4 signaling ⁶⁵ SHC1 events in ERBB2 signaling ⁶⁵ SHC1 events in ERBB4 signaling ⁶⁵	12.33	KRAS HRAS EGFR AKT1
27	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.31	TP53 MYC KRAS EGFR AKT1
28	Human T-cell leukemia virus 1 infection ³⁶	12.27	TP53 MYC KRAS HRAS CDKN2A AKT1
29	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.26	TP53 MYC KRAS HRAS EGFR AKT1
30	EGF/EGFR Signaling Pathway ¹	12.23	KRAS HRAS EGFR AKT1
31	Colorectal Cancer Metastasis ⁶³	12.23	TP53 MYC KRAS EGFR AKT1
32	mTOR Pathway ⁷⁰ Show member pathways Insulin Pathway ⁷⁰ TGF-beta Pathway ⁷⁰	12.22	TP53 KRAS HRAS AKT1
33	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	12.19	TP53 KRAS HRAS AKT1
34	Proteoglycans in cancer ³⁶	12.19	TP53 MYC KRAS HRAS EGFR AKT1
35	Signaling pathways regulating pluripotency of stem cells ³⁶	12.16	MYC KRAS HRAS AKT1
36	Integrated Breast Cancer Pathway ¹	12.16	TP53 MYC KRAS EGFR AKT1
37	NGF Pathway ⁶³ Show member pathways TRKA Signaling ⁶³	12.15	TP53 MYC KRAS HRAS AKT1
38	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.13	KRAS HRAS EGFR AKT1
39	Development EGFR signaling via small GTPases ²³ Show member pathways Development EGFR signaling via PIP3 ²³ Development PDGF signaling via MAPK cascades ²³ PDGF Pathway ¹	12.13	MYC KRAS HRAS EGFR AKT1
40	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.12	MYC KRAS HRAS AKT1
41	Signaling by PTK6 ⁶⁵ Show member pathways PTK6 Activates STAT3 ⁶⁵ PTK6 Down-Regulation ⁶⁵ PTK6 Expression ⁶⁵ PTK6 promotes HIF1A stabilization ⁶⁵ PTK6 Regulates Proteins Involved in RNA Processing ⁶⁵ PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ⁶⁵ PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ⁶⁵ RAS signaling downstream of NF1 loss-of-function variants ⁶⁵	12.11	KRAS HRAS EGFR AKT1
42	UVA-Induced MAPK Signaling ⁶³ Show member pathways UVB-Induced MAPK Signaling ⁶³	12.09	TP53 KRAS HRAS EGFR AKT1
43	Sphingolipid signaling pathway ³⁶	12.06	TP53 KRAS HRAS AKT1
44	Cellular senescence (KEGG) ³⁶	11.99	TP53 MYC KRAS HRAS CDKN2A AKT1
45	Thyroid hormone signaling pathway ³⁶	11.96	TP53 MYC KRAS HRAS AKT1
46	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.85	KRAS HRAS AKT1
47	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.79	TP53 CDKN2A AKT1
48	DNA Damage Response (only ATM dependent) ¹	11.79	TP53 MYC KRAS HRAS CDKN2A AKT1
49	Platinum drug resistance ³⁶	11.78	TP53 CDKN2A AKT1
50	Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	11.78	KRAS HRAS AKT1

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GO Terms for Respiratory System Benign Neoplasm

Cellular components related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear envelope	GO:0005635	9.46	SCGB1A1 MYC LMNTD1 IRAG2
2	multivesicular body lumen	GO:0097486	8.96	SFTPC NAPSA
3	alveolar lamellar body	GO:0097208	8.62	SFTPC NAPSA

Biological processes related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.98	TP53 NKX2-1 MYC HRAS EGFR CDKN2A
2	positive regulation of transcription, DNA-templated	GO:0045893	9.85	TP53 NKX2-1 MYC EGFR CDKN2A AKT1
3	positive regulation of protein phosphorylation	GO:0001934	9.78	KRAS HRAS EGFR AKT1
4	cellular response to drug	GO:0035690	9.69	TP53 MYC EGFR
5	positive regulation of epithelial cell proliferation	GO:0050679	9.63	MYC HRAS EGFR
6	cell cycle arrest	GO:0007050	9.62	TP53 MYC HRAS CDKN2A
7	positive regulation of MAP kinase activity	GO:0043406	9.58	KRAS HRAS EGFR
8	response to isolation stress	GO:0035900	9.49	KRAS HRAS
9	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.33	SYP KRAS HRAS
10	response to UV-A	GO:0070141	9.26	EGFR AKT1
11	Ras protein signal transduction	GO:0007265	9.26	TP53 KRAS HRAS CDKN2A
12	positive regulation of gene expression	GO:0010628	9.17	TP53 NKX2-1 MYC KRAS HRAS CDKN2A

Molecular functions related to Respiratory System Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MDM2/MDM4 family protein binding	GO:0097371	8.96	TP53 CDKN2A
2	nitric-oxide synthase regulator activity	GO:0030235	8.62	EGFR AKT1

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Sources for Respiratory System Benign Neoplasm

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