MCID: RSP005
MIFTS: 37

Respiratory System Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Cancer

MalaCards integrated aliases for Respiratory System Cancer:

Name: Respiratory System Cancer 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050615
UMLS 73 C0814136

Summaries for Respiratory System Cancer

Disease Ontology : 12 An organ system cancer located in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

MalaCards based summary : Respiratory System Cancer is related to lung cancer and parameningeal embryonal rhabdomyosarcoma. An important gene associated with Respiratory System Cancer is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. Affiliated tissues include the respiratory system, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Respiratory System Cancer

Diseases in the Respiratory System Cancer family:

Respiratory System Benign Neoplasm

Diseases related to Respiratory System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 lung cancer 30.6 AKT1 ALK AREG CD274 CEACAM5 CYP2E1
2 parameningeal embryonal rhabdomyosarcoma 11.3 ALK TP53
3 paronychia 11.3 EGFR HRAS KRAS
4 rare adenocarcinoma of the breast 11.3 AKT1 KRAS TP53
5 brain ependymoma 11.2 EGFR TP53
6 sigmoid neoplasm 11.2 CEACAM5 HRAS KRAS
7 nasal cavity adenocarcinoma 11.2 HRAS KRAS TP53
8 secondary hypertrophic osteoarthropathy 11.2 HRAS KRAS SMUG1
9 acneiform dermatitis 11.2 EGFR HRAS KRAS
10 ovarian carcinosarcoma 11.2 CD274 ENO2 TUBB3
11 mature teratoma 11.2 KRAS SMUG1 TP53
12 bronchiolo-alveolar adenocarcinoma 11.2 EGFR KRAS NKX2-1
13 apocrine adenoma 11.2 CEACAM5 HRAS KRAS
14 anal canal adenocarcinoma 11.2 CD274 HRAS KRAS
15 gallbladder squamous cell carcinoma 11.2 CEACAM5 SMUG1 TP53
16 oropharynx cancer 11.2 EGFR SMUG1 TP53
17 malignant spiradenoma 11.2 CEACAM5 SMUG1 TP53
18 mucoepidermoid esophageal carcinoma 11.2 CEACAM5 TP53
19 aggressive digital papillary adenocarcinoma 11.2 CEACAM5 HRAS KRAS
20 biliary tract neoplasm 11.2 HRAS KRAS TP53
21 meningeal melanomatosis 11.2 ENO2 HRAS TP53
22 liver lymphoma 11.2 CEACAM5 SMUG1
23 ovary serous adenocarcinoma 11.2 CEACAM5 HRAS KRAS
24 basaloid squamous cell carcinoma 11.2 EGFR ENO2 TP53
25 cecum adenocarcinoma 11.2 HRAS KRAS SMUG1
26 squamous cell papilloma 11.2 CD274 CYP2E1 TP53
27 ovarian cystadenocarcinoma 11.2 CEACAM5 HRAS KRAS
28 respiratory system benign neoplasm 11.2 ENO2 KRAS NKX2-1
29 duodenum cancer 11.2 ENO2 HRAS KRAS
30 splenic tuberculosis 11.2 CEACAM5 GRP SMUG1
31 atypical follicular adenoma 11.2 CEACAM5 ENO2 TP53
32 bartholin's duct cyst 11.2 SMUG1 TP53
33 hidradenocarcinoma 11.2 EGFR NKX2-1 TP53
34 primary peritoneal carcinoma 11.2 EGFR ERCC1 TP53
35 small intestinal adenocarcinoma 11.2 CD274 EGFR KRAS
36 penile cancer 11.2 EGFR HRAS TP53
37 skin squamous cell carcinoma 11.2 HRAS KRAS TP53
38 chondroid chordoma 11.2 CEACAM5 ENO2 TUBB3
39 adult medulloblastoma 11.2 ENO2 TP53 TUBB3
40 pleomorphic carcinoma 11.2 ALK EGFR NKX2-1 TP53
41 mucinous adenocarcinoma 11.2 ALK EGFR KRAS NKX2-1
42 pulmonary blastoma 11.2 EGFR KRAS NKX2-1 TP53
43 horseshoe kidney 11.2 EGFR ENO2 NKX2-1
44 colonic benign neoplasm 11.2 AREG CEACAM5 KRAS
45 cystic teratoma 11.2 ENO2 NKX2-1 TP53
46 mixed cell type cancer 11.2 ENO2 HRAS KRAS TP53
47 large cell neuroendocrine carcinoma 11.1 EGFR ENO2 NKX2-1
48 pharynx cancer 11.1 AKT1 EGFR SMUG1 TP53
49 intracranial chondrosarcoma 11.1 CEACAM5 TP53
50 urinary bladder small cell neuroendocrine carcinoma 11.1 ENO2 GRP

Graphical network of the top 20 diseases related to Respiratory System Cancer:



Diseases related to Respiratory System Cancer

Symptoms & Phenotypes for Respiratory System Cancer

GenomeRNAi Phenotypes related to Respiratory System Cancer according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.77 HRAS KRAS EGFR
2 Decreased viability GR00106-A-0 9.77 KRAS
3 Decreased viability GR00221-A-1 9.77 HRAS KRAS AKT1 ROS1 ALK EGFR
4 Decreased viability GR00221-A-2 9.77 HRAS KRAS AKT1 ROS1
5 Decreased viability GR00221-A-3 9.77 HRAS AKT1
6 Decreased viability GR00221-A-4 9.77 AKT1 ALK EGFR
7 Decreased viability GR00301-A 9.77 KRAS
8 Decreased viability GR00342-S-1 9.77 ROS1
9 Decreased viability GR00381-A-1 9.77 KRAS
10 Decreased viability GR00402-S-2 9.77 HRAS KRAS AKT1 ROS1 ALK EGFR
11 Decreased cell migration GR00055-A-1 9.35 HRAS KRAS AKT1 ALK EGFR

MGI Mouse Phenotypes related to Respiratory System Cancer:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 AREG CD274 AKT1 CYP2E1 EGFR ALK
2 cellular MP:0005384 10.29 ENO2 CD274 AKT1 EGFR TP53 TUBB3
3 mortality/aging MP:0010768 10.28 AREG ERCC1 CD274 AKT1 CYP2E1 EGFR
4 behavior/neurological MP:0005386 10.26 ALK ENO2 CD274 AKT1 CYP2E1 TP53
5 endocrine/exocrine gland MP:0005379 10.13 EGFR ALK AREG AKT1 TP53 HRAS
6 digestive/alimentary MP:0005381 10.1 EGFR AREG TP53 TLR9 SHOX2 KRAS
7 integument MP:0010771 10.09 EGFR ALK AREG CD274 AKT1 TP53
8 neoplasm MP:0002006 10.07 ERCC1 AKT1 CYP2E1 EGFR ALK TP53
9 nervous system MP:0003631 10.06 EGFR ALK ENO2 AKT1 TP53 TUBB3
10 reproductive system MP:0005389 9.81 EGFR ALK AREG AKT1 TP53 ROS1
11 no phenotypic analysis MP:0003012 9.8 EGFR CD274 TP53 NKX2-1 ROS1 HRAS
12 respiratory system MP:0005388 9.61 ENO2 AKT1 EGFR ALK TUBB3 TP53
13 skeleton MP:0005390 9.32 ALK CD274 AKT1 EGFR TP53 SHOX2

Drugs & Therapeutics for Respiratory System Cancer

Search Clinical Trials , NIH Clinical Center for Respiratory System Cancer

Genetic Tests for Respiratory System Cancer

Anatomical Context for Respiratory System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory System Cancer:

19
The Respiratory System

Publications for Respiratory System Cancer

Articles related to Respiratory System Cancer:

# Title Authors Year
1
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies. ( 25501063 )
2014
2
Fiber glass exposure and human respiratory system cancer risk: lack of evidence persists since 2001 IARC re-evaluation. ( 21345360 )
2011
3
Pharmaceutical production workers and the risks of mortality from respiratory system cancer and lymphatic and hematopoietic tissue cancers. ( 19620890 )
2009
4
Historical cohort study of U.S. man-made vitreous fiber production workers IX: summary of 1992 mortality follow up and analysis of respiratory system cancer among female workers. ( 14724479 )
2004
5
Historical cohort study of US man-made vitreous fiber production workers: III. Analysis of exposure-weighted measures of respirable fibers and formaldehyde in the nested case-control study of respiratory system cancer. ( 11561360 )
2001
6
Historical cohort study of US man-made vitreous fiber production workers: VI. Respiratory system cancer standardized mortality ratios adjusted for the confounding effect of cigarette smoking. ( 11561363 )
2001
7
Historical cohort study of US man-made vitreous fiber production workers: IV. Quantitative exposure-response analysis of the nested case-control study of respiratory system cancer. ( 11561361 )
2001
8
Man-made vitreous fibers and risk of respiratory system cancer: a review of the epidemiologic evidence. ( 7670920 )
1995
9
Mortality from respiratory system cancer in New South Wales and Sydney. ( 1482717 )
1992
10
Mortality from asthma, chronic obstructive pulmonary disease, respiratory system cancer, and stomach cancer among paper mill workers: a case-referent study. ( 1882851 )
1991

Variations for Respiratory System Cancer

Expression for Respiratory System Cancer

Search GEO for disease gene expression data for Respiratory System Cancer.

Pathways for Respiratory System Cancer

Pathways related to Respiratory System Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 AKT1 ALK AREG CYP2E1 EGFR HRAS
2
Show member pathways
13.54 AKT1 ALK AREG EGFR HRAS KRAS
3
Show member pathways
13.36 AKT1 ALK AREG EGFR HRAS KRAS
4
Show member pathways
13.32 AKT1 ALK AREG EGFR HRAS KRAS
5
Show member pathways
13.3 AKT1 ALK AREG EGFR HRAS KRAS
6
Show member pathways
13.09 AKT1 AREG EGFR HRAS KRAS TP53
7
Show member pathways
13.08 AKT1 ALK AREG EGFR HRAS KRAS
8
Show member pathways
13.01 AKT1 AREG EGFR HRAS KRAS TP53
9
Show member pathways
12.86 AKT1 AREG EGFR HRAS KRAS TP53
10
Show member pathways
12.82 AKT1 AREG EGFR HRAS KRAS
11
Show member pathways
12.79 AKT1 EGFR HRAS KRAS TP53
12
Show member pathways
12.76 AKT1 EGFR HRAS KRAS TP53
13 12.71 AKT1 AREG EGFR HRAS KRAS TP53
14
Show member pathways
12.69 AKT1 EGFR HRAS KRAS TP53
15 12.67 AKT1 ALK EGFR EML4 HRAS KRAS
16
Show member pathways
12.61 AKT1 EGFR HRAS KRAS TP53
17
Show member pathways
12.49 AKT1 EGFR HRAS KRAS TP53
18
Show member pathways
12.47 AKT1 ALK EGFR EML4 HRAS KRAS
19 12.44 AKT1 HRAS KRAS TP53
20
Show member pathways
12.42 AKT1 EGFR HRAS KRAS
21
Show member pathways
12.42 AKT1 EGFR HRAS KRAS TLR9
22
Show member pathways
12.4 AKT1 EGFR HRAS KRAS TP53
23
Show member pathways
12.4 AKT1 AREG EGFR HRAS KRAS TP53
24
Show member pathways
12.34 AKT1 EGFR HRAS KRAS
25
Show member pathways
12.29 AKT1 AREG EGFR HRAS KRAS TP53
26
Show member pathways
12.24 AKT1 HRAS KRAS TLR9
27
Show member pathways
12.22 AKT1 HRAS KRAS TP53
28 12.21 AKT1 EGFR HRAS KRAS
29 12.21 AKT1 EGFR HRAS KRAS TP53
30
Show member pathways
12.2 AKT1 HRAS KRAS TP53
31 12.19 AKT1 HRAS KRAS TP53
32 12.17 AKT1 EGFR KRAS TP53
33
Show member pathways
12.16 AKT1 HRAS KRAS TP53
34
Show member pathways
12.15 AKT1 EGFR HRAS KRAS
35
Show member pathways
12.15 AKT1 HRAS KRAS TP53
36
Show member pathways
12.13 AKT1 AREG EGFR HRAS KRAS
37
Show member pathways
12.12 AKT1 AREG EGFR HRAS KRAS
38
Show member pathways
12.09 AKT1 EGFR HRAS KRAS
39 12.09 AKT1 EGFR HRAS KRAS TP53
40 12.07 AKT1 EGFR KRAS TLR9 TP53
41
Show member pathways
12.05 AKT1 EGFR HRAS KRAS
42
Show member pathways
12.02 AKT1 EGFR TLR9 TP53
43 11.99 AKT1 HRAS KRAS TP53
44
Show member pathways
11.97 AKT1 EGFR TP53
45 11.97 AKT1 HRAS KRAS TP53
46 11.96 AKT1 HRAS KRAS TP53
47 11.91 AKT1 EGFR HRAS KRAS
48
Show member pathways
11.88 EGFR HRAS KRAS
49 11.84 AKT1 EGFR HRAS KRAS TP53
50
Show member pathways
11.83 AKT1 HRAS KRAS

GO Terms for Respiratory System Cancer

Biological processes related to Respiratory System Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 AKT1 AREG EGFR HRAS KRAS
2 negative regulation of apoptotic process GO:0043066 9.88 AKT1 ALK CEACAM5 EGFR ROS1 TP53
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 ALK EGFR HRAS ROS1
4 axon guidance GO:0007411 9.84 HRAS KRAS NKX2-1 TUBB3
5 positive regulation of protein phosphorylation GO:0001934 9.76 AKT1 EGFR HRAS KRAS
6 Ras protein signal transduction GO:0007265 9.73 HRAS KRAS TP53
7 positive regulation of gene expression GO:0010628 9.73 AKT1 HRAS KRAS NKX2-1 TLR9 TP53
8 positive regulation of kinase activity GO:0033674 9.72 ALK EGFR ROS1
9 positive regulation of MAP kinase activity GO:0043406 9.7 EGFR HRAS KRAS
10 positive regulation of DNA replication GO:0045740 9.61 AREG EGFR HRAS
11 cerebral cortex cell migration GO:0021795 9.58 EGFR NKX2-1
12 positive regulation of MAPK cascade GO:0043410 9.55 ALK EGFR HRAS ROS1 TLR9
13 ERBB2 signaling pathway GO:0038128 9.54 EGFR HRAS KRAS
14 response to isolation stress GO:0035900 9.51 HRAS KRAS
15 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.49 AKT1 EGFR
16 epidermal growth factor receptor signaling pathway GO:0007173 9.35 AKT1 AREG EGFR HRAS KRAS
17 response to UV-A GO:0070141 9.32 AKT1 EGFR
18 cell proliferation GO:0008283 9.23 AKT1 ALK AREG EGFR ERCC1 HRAS
19 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 AKT1 EGFR HRAS NKX2-1 SHOX2 TLR9

Molecular functions related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.58 ALK EGFR ROS1
2 protein phosphatase binding GO:0019903 9.54 EGFR ROS1 TP53
3 mitogen-activated protein kinase kinase binding GO:0031434 9.5 ALK EGFR ROS1
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 ALK EGFR ROS1
5 TFIID-class transcription factor binding GO:0001094 9.26 ERCC1 TP53
6 enzyme binding GO:0019899 9.02 AKT1 CYP2E1 EGFR NKX2-1 TP53
7 nitric-oxide synthase regulator activity GO:0030235 8.96 AKT1 EGFR

Sources for Respiratory System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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