MCID: RSP005
MIFTS: 41

Respiratory System Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Cancer

MalaCards integrated aliases for Respiratory System Cancer:

Name: Respiratory System Cancer 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050615
UMLS 73 C0814136

Summaries for Respiratory System Cancer

Disease Ontology : 12 An organ system cancer located in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

MalaCards based summary : Respiratory System Cancer is related to tracheal cancer and lung cancer. An important gene associated with Respiratory System Cancer is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include lung, brain and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Respiratory System Cancer

Diseases in the Respiratory System Cancer family:

Respiratory System Benign Neoplasm

Diseases related to Respiratory System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 tracheal cancer 31.9 CEACAM5 ENO2 SMUG1
2 lung cancer 31.2 AKT1 ALK AREG CD274 CDH1 CEACAM5
3 paranasal sinus cancer 10.9
4 periampullary adenoma 10.4 HRAS KRAS
5 hyperplastic polyposis syndrome 10.4 KRAS TP53
6 benign struma ovarii 10.4 HRAS SMUG1
7 cellular ependymoma 10.4 SMUG1 TP53
8 protoplasmic astrocytoma 10.4 SMUG1 TP53
9 colloid adenoma 10.4 SMUG1 TP53
10 bartholin's duct cyst 10.4 SMUG1 TP53
11 pharynx squamous cell carcinoma 10.4 AKT1 SMUG1
12 actinic cheilitis 10.4 ERCC1 TP53
13 cerebral convexity meningioma 10.4 CDH1 TP53
14 malignant ectomesenchymoma 10.4 ENO2 HRAS
15 gallbladder small cell carcinoma 10.4 ENO2 SMUG1
16 urachal adenocarcinoma 10.4 CEACAM5 KRAS
17 extrahepatic bile duct adenocarcinoma 10.4 CDH1 ENO2
18 melanotic medulloblastoma 10.4 CEACAM5 ENO2
19 breast ductal carcinoma 10.4 CDH1 EGFR TP53
20 gliosarcoma 10.4 EGFR ENO2 TP53
21 tongue squamous cell carcinoma 10.4 AKT1 CDH1 TP53
22 autosomal genetic disease 10.4 ERCC1 TP53 VEGFA
23 mucoepidermoid carcinoma 10.4 AREG CEACAM5 EGFR
24 paronychia 10.4 EGFR HRAS KRAS
25 lymphoma, non-hodgkin, familial 10.4 ALK SMUG1 TLR9 TP53
26 rare adenocarcinoma of the breast 10.4 AKT1 KRAS TP53
27 sigmoid neoplasm 10.4 CEACAM5 HRAS KRAS
28 carcinosarcoma 10.4 HRAS KRAS TP53
29 nasal cavity adenocarcinoma 10.4 HRAS KRAS TP53
30 apocrine adenoma 10.4 CEACAM5 HRAS KRAS
31 papillary adenocarcinoma 10.4 CDH1 CEACAM5 TP53
32 secondary hypertrophic osteoarthropathy 10.4 HRAS KRAS SMUG1
33 parameningeal embryonal rhabdomyosarcoma 10.4 ALK TP53
34 anal canal adenocarcinoma 10.4 CD274 HRAS KRAS
35 mature teratoma 10.4 KRAS SMUG1 TP53
36 acneiform dermatitis 10.4 EGFR HRAS KRAS
37 pulmonary blastoma 10.4 EGFR KRAS TP53
38 malignant spiradenoma 10.4 CEACAM5 SMUG1 TP53
39 aggressive digital papillary adenocarcinoma 10.4 CEACAM5 HRAS KRAS
40 pleomorphic carcinoma 10.4 ALK CD274 EGFR TP53
41 biliary tract neoplasm 10.4 HRAS KRAS TP53
42 soft tissue sarcoma 10.4 EGFR TP53 VEGFA
43 meningeal melanomatosis 10.4 ENO2 HRAS TP53
44 brain ependymoma 10.4 EGFR TP53
45 cecum adenocarcinoma 10.4 HRAS KRAS SMUG1
46 mucinous adenocarcinoma 10.4 ALK EGFR KRAS
47 tongue disease 10.4 CDH1 TLR9 TP53
48 atypical follicular adenoma 10.4 CEACAM5 ENO2 TP53
49 lung adenoid cystic carcinoma 10.4 ALK EML4 HRAS KRAS
50 basaloid squamous cell carcinoma 10.4 EGFR ENO2 TP53

Graphical network of the top 20 diseases related to Respiratory System Cancer:



Diseases related to Respiratory System Cancer

Symptoms & Phenotypes for Respiratory System Cancer

GenomeRNAi Phenotypes related to Respiratory System Cancer according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.81 EGFR HRAS KRAS
2 Decreased viability GR00106-A-0 9.81 KRAS
3 Decreased viability GR00221-A-1 9.81 AKT1 ALK CDH1 EGFR HRAS KRAS
4 Decreased viability GR00221-A-2 9.81 AKT1 HRAS KRAS ROS1
5 Decreased viability GR00221-A-3 9.81 AKT1 HRAS
6 Decreased viability GR00221-A-4 9.81 AKT1 ALK EGFR
7 Decreased viability GR00301-A 9.81 CDH1 KRAS
8 Decreased viability GR00342-S-1 9.81 ROS1
9 Decreased viability GR00381-A-1 9.81 KRAS
10 Decreased viability GR00402-S-2 9.81 AKT1 ALK CDH1 EGFR HRAS KRAS
11 Decreased cell migration GR00055-A-1 9.35 AKT1 ALK EGFR HRAS KRAS

MGI Mouse Phenotypes related to Respiratory System Cancer:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 AKT1 CD274 CDH1 EGFR ENO2 ERCC1
2 homeostasis/metabolism MP:0005376 10.35 AKT1 ALK AREG CD274 CDH1 CYP2E1
3 mortality/aging MP:0010768 10.31 AKT1 ALK AREG CD274 CDH1 CYP2E1
4 growth/size/body region MP:0005378 10.27 AKT1 ALK AREG CDH1 EGFR ENO2
5 cardiovascular system MP:0005385 10.26 AKT1 AREG CDH1 CYP2E1 EGFR HRAS
6 endocrine/exocrine gland MP:0005379 10.21 AKT1 ALK AREG CDH1 EGFR ERCC1
7 integument MP:0010771 10.2 AKT1 ALK AREG CD274 CDH1 EGFR
8 digestive/alimentary MP:0005381 10.18 AREG CDH1 EGFR HRAS KRAS SHOX2
9 neoplasm MP:0002006 10.11 AKT1 ALK CDH1 CYP2E1 EGFR ERCC1
10 craniofacial MP:0005382 10.08 EGFR ENO2 HRAS KRAS SHOX2 TP53
11 liver/biliary system MP:0005370 9.98 AKT1 CYP2E1 EGFR ERCC1 KRAS TP53
12 no phenotypic analysis MP:0003012 9.92 CD274 CDH1 EGFR HRAS KRAS ROS1
13 reproductive system MP:0005389 9.85 AKT1 ALK AREG CDH1 EGFR ERCC1
14 renal/urinary system MP:0005367 9.8 EGFR ERCC1 HRAS KRAS TLR9 TP53
15 respiratory system MP:0005388 9.61 AKT1 ALK EGFR ENO2 HRAS KRAS
16 skeleton MP:0005390 9.32 AKT1 ALK CD274 EGFR ERCC1 HRAS

Drugs & Therapeutics for Respiratory System Cancer

Search Clinical Trials , NIH Clinical Center for Respiratory System Cancer

Genetic Tests for Respiratory System Cancer

Anatomical Context for Respiratory System Cancer

MalaCards organs/tissues related to Respiratory System Cancer:

41
Lung, Brain, Bone, Colon, Tongue, Tonsil, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory System Cancer:

19
The Respiratory System

Publications for Respiratory System Cancer

Articles related to Respiratory System Cancer:

# Title Authors Year
1
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies. ( 25501063 )
2014
2
Fiber glass exposure and human respiratory system cancer risk: lack of evidence persists since 2001 IARC re-evaluation. ( 21345360 )
2011
3
Pharmaceutical production workers and the risks of mortality from respiratory system cancer and lymphatic and hematopoietic tissue cancers. ( 19620890 )
2009
4
Historical cohort study of U.S. man-made vitreous fiber production workers IX: summary of 1992 mortality follow up and analysis of respiratory system cancer among female workers. ( 14724479 )
2004
5
Historical cohort study of US man-made vitreous fiber production workers: III. Analysis of exposure-weighted measures of respirable fibers and formaldehyde in the nested case-control study of respiratory system cancer. ( 11561360 )
2001
6
Historical cohort study of US man-made vitreous fiber production workers: VI. Respiratory system cancer standardized mortality ratios adjusted for the confounding effect of cigarette smoking. ( 11561363 )
2001
7
Historical cohort study of US man-made vitreous fiber production workers: IV. Quantitative exposure-response analysis of the nested case-control study of respiratory system cancer. ( 11561361 )
2001
8
Man-made vitreous fibers and risk of respiratory system cancer: a review of the epidemiologic evidence. ( 7670920 )
1995
9
Mortality from respiratory system cancer in New South Wales and Sydney. ( 1482717 )
1992
10
Mortality from asthma, chronic obstructive pulmonary disease, respiratory system cancer, and stomach cancer among paper mill workers: a case-referent study. ( 1882851 )
1991

Variations for Respiratory System Cancer

Expression for Respiratory System Cancer

Search GEO for disease gene expression data for Respiratory System Cancer.

Pathways for Respiratory System Cancer

Pathways related to Respiratory System Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 AKT1 ALK AREG CDH1 EGFR HRAS
2
Show member pathways
13.74 AKT1 ALK AREG CYP2E1 EGFR HRAS
3
Show member pathways
13.55 AKT1 ALK AREG CDH1 EGFR HRAS
4
Show member pathways
13.43 AKT1 ALK AREG EGFR HRAS KRAS
5
Show member pathways
13.39 AKT1 ALK AREG EGFR HRAS KRAS
6
Show member pathways
13.36 AKT1 AREG CDH1 EGFR HRAS KRAS
7
Show member pathways
13.29 AKT1 ALK AREG CDH1 EGFR HRAS
8
Show member pathways
13.27 AKT1 AREG EGFR HRAS KRAS TLR9
9
Show member pathways
13.13 AKT1 AREG EGFR HRAS KRAS TP53
10
Show member pathways
13.12 AKT1 EGFR HRAS KRAS TP53 VEGFA
11
Show member pathways
13.11 AKT1 ALK AREG EGFR HRAS KRAS
12
Show member pathways
13.09 AKT1 EGFR HRAS KRAS TUBB3 VEGFA
13
Show member pathways
13.07 AKT1 CDH1 HRAS KRAS TP53 VEGFA
14
Show member pathways
13.03 AKT1 AREG EGFR HRAS KRAS TP53
15
Show member pathways
13.02 AKT1 EGFR HRAS KRAS TP53 VEGFA
16
Show member pathways
12.82 AKT1 AREG CDH1 EGFR HRAS KRAS
17
Show member pathways
12.81 AKT1 CDH1 EGFR HRAS KRAS TP53
18
Show member pathways
12.79 AKT1 EGFR HRAS KRAS TP53
19
Show member pathways
12.78 AKT1 CDH1 EGFR HRAS KRAS VEGFA
20
Show member pathways
12.77 AKT1 CDH1 HRAS KRAS TP53
21 12.77 AKT1 AREG EGFR HRAS KRAS TP53
22
Show member pathways
12.74 AKT1 EGFR HRAS KRAS TP53
23
Show member pathways
12.73 AKT1 EGFR HRAS KRAS VEGFA
24
Show member pathways
12.65 AKT1 EGFR HRAS KRAS TP53
25 12.63 AKT1 ALK CDH1 EGFR EML4 HRAS
26 12.58 EGFR HRAS KRAS TP53 VEGFA
27
Show member pathways
12.56 AKT1 EGFR HRAS KRAS TP53
28
Show member pathways
12.5 AKT1 EGFR HRAS KRAS TP53
29
Show member pathways
12.49 AKT1 AREG CDH1 EGFR HRAS KRAS
30 12.47 AKT1 HRAS KRAS TP53
31
Show member pathways
12.46 AKT1 EGFR HRAS KRAS
32
Show member pathways
12.46 AKT1 EGFR HRAS KRAS TLR9 VEGFA
33
Show member pathways
12.45 AKT1 HRAS KRAS VEGFA
34
Show member pathways
12.41 ALK AREG CDH1 EGFR HRAS KRAS
35
Show member pathways
12.38 AKT1 EGFR HRAS KRAS
36
Show member pathways
12.33 AKT1 AREG EGFR KRAS TP53
37
Show member pathways
12.31 AKT1 AREG EGFR HRAS KRAS TP53
38
Show member pathways
12.3 AKT1 HRAS KRAS TP53 VEGFA
39 12.28 AKT1 EGFR HRAS KRAS TP53 VEGFA
40
Show member pathways
12.28 AKT1 ALK CDH1 EGFR EML4 HRAS
41
Show member pathways
12.27 AKT1 HRAS KRAS TLR9
42
Show member pathways
12.26 AKT1 EGFR HRAS KRAS TP53
43 12.25 AKT1 EGFR HRAS KRAS
44 12.23 AKT1 HRAS KRAS TP53
45
Show member pathways
12.23 AKT1 HRAS KRAS TP53
46
Show member pathways
12.21 AKT1 HRAS KRAS TP53
47
Show member pathways
12.2 AKT1 EGFR HRAS KRAS
48
Show member pathways
12.2 AKT1 HRAS KRAS TP53
49 12.17 AKT1 EGFR HRAS KRAS TP53
50
Show member pathways
12.16 AKT1 EGFR HRAS KRAS

GO Terms for Respiratory System Cancer

Cellular components related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.86 AKT1 ALK AREG CDH1 CYP2E1 EGFR
2 cell surface GO:0009986 9.17 AREG CD274 CDH1 CEACAM5 EGFR ROS1
3 membrane GO:0016020 10.06 AKT1 ALK AREG CD274 CDH1 CEACAM5

Biological processes related to Respiratory System Cancer according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 AKT1 AREG EGFR HRAS KRAS VEGFA
2 negative regulation of gene expression GO:0010629 9.87 AKT1 HRAS ROS1 VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 ALK EGFR HRAS ROS1
4 positive regulation of cell migration GO:0030335 9.84 CD274 EGFR HRAS VEGFA
5 positive regulation of gene expression GO:0010628 9.8 AKT1 HRAS KRAS TLR9 TP53 VEGFA
6 negative regulation of apoptotic process GO:0043066 9.8 AKT1 ALK CEACAM5 EGFR ROS1 TP53
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 AREG TP53 VEGFA
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 AKT1 EGFR VEGFA
9 Ras protein signal transduction GO:0007265 9.69 HRAS KRAS TP53
10 positive regulation of epithelial cell proliferation GO:0050679 9.67 EGFR HRAS VEGFA
11 epidermal growth factor receptor signaling pathway GO:0007173 9.61 AKT1 AREG EGFR
12 cell proliferation GO:0008283 9.56 AKT1 ALK AREG EGFR ERCC1 HRAS
13 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.52 EGFR TP53
14 obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.48 AKT1 EGFR
15 response to isolation stress GO:0035900 9.46 HRAS KRAS
16 positive regulation of MAP kinase activity GO:0043406 9.46 EGFR HRAS KRAS VEGFA
17 response to UV-A GO:0070141 9.37 AKT1 EGFR
18 positive regulation of protein phosphorylation GO:0001934 9.17 AKT1 ALK EGFR HRAS KRAS ROS1

Molecular functions related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.54 EGFR ROS1 TP53
2 transmembrane signaling receptor activity GO:0004888 9.46 ALK EGFR ROS1 TLR9
3 TFIID-class transcription factor complex binding GO:0001094 9.32 ERCC1 TP53
4 nitric-oxide synthase regulator activity GO:0030235 9.26 AKT1 EGFR
5 identical protein binding GO:0042802 9.17 AKT1 ALK CDH1 CEACAM5 EGFR TP53
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ALK EGFR ROS1

Sources for Respiratory System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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