MCID: RSP005
MIFTS: 29

Respiratory System Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Respiratory System Cancer

MalaCards integrated aliases for Respiratory System Cancer:

Name: Respiratory System Cancer 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050615
UMLS 70 C0814136

Summaries for Respiratory System Cancer

Disease Ontology : 12 An organ system cancer located in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

MalaCards based summary : Respiratory System Cancer is related to lung cancer and nasopharyngeal carcinoma. An important gene associated with Respiratory System Cancer is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. Affiliated tissues include respiratory system.

Related Diseases for Respiratory System Cancer

Diseases related to Respiratory System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 lung cancer 32.4 MIR9-1 MIR486-1 MIR365A MIR34A MIR31 MIR30A
2 nasopharyngeal carcinoma 30.7 MIR9-1 MIR31 MIR30A MIR21 MIR17 MIR143
3 pulmonary disease, chronic obstructive 30.7 MIR21 MIR199A1 MIR182 MIR17 MIR142 MIR126
4 gastric cancer 30.6 MIR9-1 MIR34A MIR21 MIR199A1 MIR17 MIR145
5 paranasal sinus cancer 11.0
6 tracheal cancer 11.0
7 bronchus cancer 11.0
8 ovary epithelial cancer 10.7 MIR9-1 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
9 malignant ovarian surface epithelial-stromal neoplasm 10.7 MIR9-1 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A
10 tongue disease 10.7 MIR486-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
11 leukocyte disease 10.7 MIR30A MIR21 MIR200B MIR199A1 MIR196A1 MIR17
12 biliary tract disease 10.7 MIR9-1 MIR486-1 MIR30A MIR199A1 MIR196A1 MIR17
13 bone cancer 10.7 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR193A MIR17
14 bile duct disease 10.7 MIR9-1 MIR486-1 MIR30A MIR199A1 MIR196A1 MIR17
15 retinal cancer 10.7 MIR9-1 MIR486-1 MIR365A MIR199A1 MIR196A1 MIR193A
16 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.7 MIR9-1 MIR486-1 MIR21 MIR199A1 MIR196A1 MIR17
17 glucose metabolism disease 10.7 MIR9-1 MIR486-1 MIR30A MIR21 MIR199A1 MIR196A1
18 bone inflammation disease 10.7 MIR34A MIR30A MIR21 MIR199A1 MIR196A1 MIR17
19 inherited metabolic disorder 10.7 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
20 spinal disease 10.7 MIR9-1 MIR486-1 MIR21 MIR199A1 MIR196A1 MIR193A
21 autoimmune disease of musculoskeletal system 10.7 MIR34A MIR30A MIR21 MIR199A1 MIR196A1 MIR17
22 eye disease 10.7 MIR9-1 MIR486-1 MIR365A MIR30A MIR21 MIR199A1
23 autosomal genetic disease 10.7 MIR9-1 MIR486-1 MIR21 MIR199A1 MIR196A1 MIR193A
24 integumentary system disease 10.7 MIR9-1 MIR31 MIR30A MIR21 MIR199A1 MIR196A1
25 overnutrition 10.7 MIR486-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
26 sensory system disease 10.7 MIR9-1 MIR486-1 MIR365A MIR30A MIR21 MIR199A1
27 mouth disease 10.7 MIR9-1 MIR486-1 MIR31 MIR21 MIR196A1 MIR17
28 ovarian disease 10.7 MIR9-1 MIR486-1 MIR30A MIR21 MIR200B MIR199A1
29 cell type benign neoplasm 10.7 MIR30A MIR21 MIR199A1 MIR196A1 MIR193A MIR17
30 bile duct adenocarcinoma 10.7 MIR9-1 MIR486-1 MIR31 MIR30A MIR21 MIR199A1
31 disease by infectious agent 10.7 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
32 ocular cancer 10.7 MIR9-1 MIR365A MIR30A MIR199A1 MIR196A1 MIR193A
33 chromosomal disease 10.7 MIR9-1 MIR486-1 MIR31 MIR21 MIR200B MIR196A1
34 bone marrow cancer 10.7 MIR9-1 MIR486-1 MIR34A MIR30A MIR21 MIR199A1
35 autonomic nervous system neoplasm 10.7 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
36 peripheral nervous system disease 10.7 MIR9-1 MIR486-1 MIR34A MIR21 MIR199A1 MIR196A1
37 peripheral nervous system neoplasm 10.7 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
38 central nervous system cancer 10.7 MIR9-1 MIR486-1 MIR34A MIR30A MIR21 MIR199A1
39 retinal vascular disease 10.7 MIR365A MIR30A MIR21 MIR199A1 MIR17 MIR126
40 central nervous system disease 10.7 MIR9-1 MIR34A MIR30A MIR21 MIR199A1 MIR196A1
41 nasopharyngeal disease 10.7 MIR9-1 MIR486-1 MIR365A MIR31 MIR30A MIR21
42 upper respiratory tract disease 10.7 MIR9-1 MIR486-1 MIR365A MIR31 MIR30A MIR21
43 acquired metabolic disease 10.7 MIR9-1 MIR486-1 MIR34A MIR30A MIR21 MIR199A1
44 arteries, anomalies of 10.7 MIR9-1 MIR486-1 MIR34A MIR30A MIR21 MIR199A1
45 pharynx cancer 10.7 MIR9-1 MIR486-1 MIR31 MIR30A MIR21 MIR199A1
46 oral cavity cancer 10.7 MIR9-1 MIR486-1 MIR31 MIR30A MIR21 MIR199A1
47 myeloma, multiple 10.7 MIR9-1 MIR30A MIR21 MIR199A1 MIR196A1 MIR17
48 laryngeal disease 10.7 MIR9-1 MIR486-1 MIR365A MIR34A MIR31 MIR21
49 intestinal benign neoplasm 10.7 MIR21 MIR199A1 MIR196A1 MIR17 MIR145 MIR143
50 mature b-cell neoplasm 10.6 MIR9-1 MIR199A1 MIR196A1 MIR17 MIR142 MIR126

Graphical network of the top 20 diseases related to Respiratory System Cancer:



Diseases related to Respiratory System Cancer

Symptoms & Phenotypes for Respiratory System Cancer

Drugs & Therapeutics for Respiratory System Cancer

Search Clinical Trials , NIH Clinical Center for Respiratory System Cancer

Genetic Tests for Respiratory System Cancer

Anatomical Context for Respiratory System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Respiratory System Cancer:

19
Respiratory System

Publications for Respiratory System Cancer

Articles related to Respiratory System Cancer:

(show all 40)
# Title Authors PMID Year
1
The use of complementary and alternative medicine among lymphoma and cancer patients with a solid tumor: Oncology clinics at Northern and Southern Turkey. 61
31780026 2019
2
Non-Analgesic Symptomatic or Disease-Modifying Potential of TRPA1. 61
31547502 2019
3
Prognostic role of lncRNA TUG1 for cancer outcome: Evidence from 840 cancer patients. 61
28548946 2017
4
The association of remotely sensed outdoor fine particulate matter with cancer incidence of respiratory system in the USA. 61
28276881 2017
5
Tracheal cancer - treatment results, prognostic factors and incidence of other neoplasms. 61
27904449 2016
6
Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies. 61
26221222 2015
7
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies. 61
25501063 2014
8
Characteristics of malignant tumors in 230 husband-wife pairs. 61
24696073 2014
9
Age at menarche and natural menopause and number of reproductive years in association with mortality: results from a median follow-up of 11.2 years among 31,955 naturally menopausal Chinese women. 61
25090234 2014
10
New perspectives in nanomedicine. 61
23811125 2013
11
Mortality among shipbreaking workers in Taiwan--a retrospective cohort study from 1985 to 2008. 61
23532723 2013
12
An ecological study of cancer mortality rates in high altitude counties of the United States. 61
22724612 2012
13
Mortality in a cohort of cement workers in a plant of Central Italy. 61
21766208 2012
14
Fiber glass exposure and human respiratory system cancer risk: lack of evidence persists since 2001 IARC re-evaluation. 61
21345360 2011
15
Mortality patterns of Army Chemical Corps veterans who were occupationally exposed to herbicides in Vietnam. 61
20382334 2010
16
Pharmaceutical production workers and the risks of mortality from respiratory system cancer and lymphatic and hematopoietic tissue cancers. 61
19620890 2009
17
Mortality among workers exposed to acrylonitrile in fiber production: an update. 61
18469624 2008
18
Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers. 61
17544557 2007
19
Mortality patterns among workers exposed to acrylamide: updated follow up. 61
17215717 2007
20
Workers' exposures and potential health risks to air toxics in a petrochemical complex assessed by improved methodology. 61
16158313 2006
21
Historical cohort study of U.S. man-made vitreous fiber production workers IX: summary of 1992 mortality follow up and analysis of respiratory system cancer among female workers. 61
14724479 2004
22
The Drake Health Registry Study: cause-specific mortality experience of workers potentially exposed to beta-naphthylamine. 61
12929148 2003
23
Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident". 61
12916742 2003
24
Fiber glass and rock/slag wool exposure of professional and do-it-yourself installers. 61
12662907 2003
25
Historical cohort study of US man-made vitreous fiber production workers: I. 1992 fiberglass cohort follow-up: initial findings. 61
11561358 2001
26
Historical cohort study of US man-made vitreous fiber production workers: III. Analysis of exposure-weighted measures of respirable fibers and formaldehyde in the nested case-control study of respiratory system cancer. 61
11561360 2001
27
Historical cohort study of US man-made vitreous fiber production workers: IV. Quantitative exposure-response analysis of the nested case-control study of respiratory system cancer. 61
11561361 2001
28
Historical cohort study of US man-made vitreous fiber production workers: V. Tobacco-smoking habits. 61
11561362 2001
29
Historical cohort study of US man-made vitreous fiber production workers: VI. Respiratory system cancer standardized mortality ratios adjusted for the confounding effect of cigarette smoking. 61
11561363 2001
30
Historical cohort study of US man-made vitreous fiber production workers: II. Mortality from mesothelioma. 61
11561359 2001
31
Man-made vitreous fibers and risk of respiratory system cancer: a review of the epidemiologic evidence. 61
7670920 1995
32
Mortality from respiratory system cancer in New South Wales and Sydney. 61
1482717 1992
33
Mortality from asthma, chronic obstructive pulmonary disease, respiratory system cancer, and stomach cancer among paper mill workers: a case-referent study. 61
1882851 1991
34
Formaldehyde exposures from tobacco smoke: a review. 61
2665532 1989
35
The incidence of cancer in schizophrenic patients. 61
2592890 1989
36
[Neoplasm risk in men occupationally exposed to asbestos dust]. 61
3773695 1986
37
Cancer mortality and solvent exposures in the rubber industry. 61
6549104 1984
38
Excess lung cancer risk in a synthetic chemicals plant. 61
6277613 1981
39
Statistical studies of mortality and air pollution. Multiple regression analyses by cause of death. 61
6969936 1980
40
Relative frequency and survival results of cancer seen at a county hospital. 61
642514 1978

Variations for Respiratory System Cancer

Expression for Respiratory System Cancer

Search GEO for disease gene expression data for Respiratory System Cancer.

Pathways for Respiratory System Cancer

Pathways related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34A MIR31 MIR30A MIR21 MIR200B
2 11.43 MIR9-1 MIR21 MIR182 MIR125A
3 10.27 MIR199A1 MIR145

GO Terms for Respiratory System Cancer

Cellular components related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 MIR9-1 MIR34A MIR21 MIR17 MIR145 MIR143
2 extracellular space GO:0005615 9.7 MIR486-1 MIR31 MIR30A MIR21 MIR199A1 MIR182
3 extracellular vesicle GO:1903561 9.23 MIR365A MIR34A MIR30A MIR21 MIR193A MIR17

Biological processes related to Respiratory System Cancer according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.95 MIR34A MIR21 MIR200B MIR17 MIR125A
2 positive regulation of protein kinase B signaling GO:0051897 9.9 MIR21 MIR199A1 MIR143 MIR126
3 negative regulation of inflammatory response GO:0050728 9.84 MIR31 MIR145 MIR142 MIR126
4 negative regulation of cell migration GO:0030336 9.8 MIR9-1 MIR34A MIR21 MIR145 MIR126
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.77 MIR199A1 MIR196A1 MIR193A
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.73 MIR21 MIR199A1 MIR145
7 positive regulation of angiogenesis GO:0045766 9.73 MIR31 MIR30A MIR21 MIR199A1 MIR143 MIR126
8 positive regulation of sprouting angiogenesis GO:1903672 9.7 MIR31 MIR126 MIR125A
9 negative regulation of angiogenesis GO:0016525 9.7 MIR34A MIR21 MIR200B MIR193A MIR145 MIR143
10 negative regulation of vascular endothelial cell proliferation GO:1905563 9.69 MIR34A MIR193A MIR126
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.67 MIR31 MIR30A MIR143 MIR126
12 negative regulation of cardiac muscle hypertrophy GO:0010614 9.66 MIR21 MIR145
13 regulation of smooth muscle contraction GO:0006940 9.65 MIR145 MIR143
14 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.65 MIR34A MIR17
15 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.65 MIR199A1 MIR17
16 positive regulation of connective tissue replacement GO:1905205 9.64 MIR34A MIR199A1
17 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.64 MIR21 MIR125A
18 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR199A1 MIR17
19 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.63 MIR31 MIR125A
20 positive regulation of metalloendopeptidase activity GO:1904685 9.62 MIR21 MIR17
21 negative regulation of vascular wound healing GO:0061044 9.62 MIR34A MIR200B
22 negative regulation of vascular endothelial growth factor production GO:1904046 9.62 MIR34A MIR199A1 MIR17 MIR125A
23 angiotensin-activated signaling pathway GO:0038166 9.61 MIR145 MIR143
24 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
25 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.61 MIR34A MIR21 MIR182
26 aorta smooth muscle tissue morphogenesis GO:0060414 9.58 MIR145 MIR143
27 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.58 MIR17 MIR143
28 gene silencing by miRNA GO:0035195 9.58 MIR9-1 MIR486-1 MIR365A MIR34A MIR31 MIR30A
29 regulation of phenotypic switching GO:1900239 9.57 MIR145 MIR143
30 miRNA mediated inhibition of translation GO:0035278 9.56 MIR9-1 MIR365A MIR31 MIR21 MIR200B MIR182
31 negative regulation of vascular smooth muscle cell dedifferentiation GO:1905175 9.49 MIR182 MIR145
32 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.48 MIR145 MIR143
33 negative regulation of interleukin-16 production GO:0032699 9.46 MIR145 MIR125A

Molecular functions related to Respiratory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.77 MIR9-1 MIR34A MIR31 MIR30A MIR21 MIR200B
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.55 MIR9-1 MIR365A MIR34A MIR31 MIR30A MIR21
3 RNA polymerase II complex binding GO:0000993 9.33 MIR145 MIR126 MIR125A

Sources for Respiratory System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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