RHR
MCID: RST023
MIFTS: 40

Resting Heart Rate, Variation in (RHR)

Categories: Genetic diseases

Aliases & Classifications for Resting Heart Rate, Variation in

MalaCards integrated aliases for Resting Heart Rate, Variation in:

Name: Resting Heart Rate, Variation in 57
Resting Heart Rate 57 29 54 6 39 17
Rhr 57

Classifications:



External Ids:

OMIM® 57 607276

Summaries for Resting Heart Rate, Variation in

MalaCards based summary : Resting Heart Rate, Variation in, also known as resting heart rate, is related to congestive heart failure and myocardial infarction. An important gene associated with Resting Heart Rate, Variation in is ADRB1 (Adrenoceptor Beta 1), and among its related pathways/superpathways are NFAT and Cardiac Hypertrophy and cGMP-PKG signaling pathway. The drugs Bisoprolol and Natriuretic Peptide, Brain have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and endothelial.

More information from OMIM: 607276

Related Diseases for Resting Heart Rate, Variation in

Diseases related to Resting Heart Rate, Variation in via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 congestive heart failure 30.6 ADRB2 ADRB1
2 myocardial infarction 29.4 ADRB2 ADRB1 ADRA2B
3 type 2 diabetes mellitus 29.3 LEPQTL1 ADRB2 ADRB1 ADRA2B
4 heart disease 10.7
5 atrial fibrillation 10.6
6 atherosclerosis susceptibility 10.6
7 coronary heart disease 1 10.6
8 diabetes mellitus 10.6
9 arteries, anomalies of 10.5
10 lipoprotein quantitative trait locus 10.5
11 vascular disease 10.4
12 lipid metabolism disorder 10.4
13 post-traumatic stress disorder 10.4
14 autonomic dysfunction 10.4
15 cardiac conduction defect 10.3
16 body mass index quantitative trait locus 1 10.3
17 ischemia 10.3
18 stroke, ischemic 10.3
19 anxiety 10.3
20 angina pectoris 10.3
21 autonomic neuropathy 10.3
22 atrial standstill 1 10.2
23 hypertension, essential 10.2
24 systemic lupus erythematosus 10.2
25 dilated cardiomyopathy 10.2
26 transient cerebral ischemia 10.2
27 chronic kidney disease 10.2
28 neuropathy 10.2
29 lupus erythematosus 10.2
30 hypercholesterolemia, familial, 1 10.1
31 thrombophilia due to thrombin defect 10.1
32 hutterite cerebroosteonephrodysplasia syndrome 10.1
33 ocular motor apraxia 10.1
34 pulmonary disease, chronic obstructive 10.1
35 peripheral vascular disease 10.1
36 sick sinus syndrome 10.1
37 impotence 10.1
38 rectum cancer 10.1
39 panic disorder 10.1
40 acute stress disorder 10.1
41 cerebrovascular disease 10.1
42 hyperthyroidism 10.1
43 pure autonomic failure 10.1
44 depression 10.1
45 brain injury 10.1
46 renovascular hypertension 10.0
47 aortic aneurysm, familial abdominal, 1 9.9
48 colorectal cancer 9.9
49 cardiac arrhythmia 9.9
50 obsessive-compulsive disorder 9.9

Graphical network of the top 20 diseases related to Resting Heart Rate, Variation in:



Diseases related to Resting Heart Rate, Variation in

Symptoms & Phenotypes for Resting Heart Rate, Variation in

Clinical features from OMIM®:

607276 (Updated 05-Apr-2021)

Drugs & Therapeutics for Resting Heart Rate, Variation in

Drugs for Resting Heart Rate, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisoprolol Approved Phase 4 66722-44-9 2405
2 Natriuretic Peptide, Brain Phase 2, Phase 3
3
Metoprolol Approved, Investigational Phase 2 37350-58-6, 51384-51-1 4171
4
Sodium citrate Approved, Investigational Phase 2 68-04-2
5
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
6
Nitric Oxide Approved Phase 2 10102-43-9 145068
7
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
9 Vasodilator Agents Phase 2
10 Citrate Phase 2
11 Phosphodiesterase Inhibitors Phase 2
12 Sildenafil Citrate Phase 2 171599-83-0
13 Phosphodiesterase 5 Inhibitors Phase 2
14 Vitamin B9 Phase 2
15 Nutrients Phase 2
16 Trace Elements Phase 2
17 Micronutrients Phase 2
18 Hematinics Phase 2
19 Folate Phase 2
20 Vitamin B Complex Phase 2
21 Vitamins Phase 2
22
L-Alanine Nutraceutical Phase 2 56-41-7 5950
23
Histidine Investigational, Nutraceutical Phase 2 71-00-1 6274
24
Sulfamethazine Approved, Investigational, Vet_approved Phase 1 57-68-1 5327
25
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
26
Isoproterenol Approved, Investigational 7683-59-2 3779
27
Carbon monoxide Approved, Investigational 630-08-0 281
28
Metronidazole Approved 443-48-1 4173
29
Atenolol Approved 29122-68-7 2249
30
Ibuprofen Approved 15687-27-1 3672
31
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
32
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
33
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
34
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
35 Adrenergic alpha-Agonists
36 Cardiotonic Agents
37 Adrenergic beta-Agonists
38 Anti-Asthmatic Agents
39 Respiratory System Agents
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors
41 Sympathomimetics
42 Hypnotics and Sedatives
43 Muscarinic Antagonists
44
Glycopyrrolate 596-51-0 3494
45 Cholinergic Agents
46 Anesthetics
47 Adrenergic Agonists
48 Bronchodilator Agents
49 Cholinergic Antagonists
50 Vitamin D2

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Patients With Essential Hypertension Completed NCT01251146 Phase 4 Bisoprolol;Atenolol
2 Effect of Transcranial Direct Current Stimulation Associated With Aerobic Exercise Training for Patients With Fibromyalgia Completed NCT02358902 Phase 2, Phase 3
3 Bisoprolol for Early Cardiomyopathy in Duchenne Muscular Dystrophy: a Randomized, Controlled Trial Recruiting NCT03779646 Phase 2, Phase 3 Bisoprolol Fumarate
4 A Phase 3, Open-label, Multicenter Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients With Elevated Resting Heart Rate Withdrawn NCT03619187 Phase 3 Ivabradine
5 Improving Right Ventricular Function in Young Adults Born Preterm: A Pilot Study Completed NCT03696758 Phase 2 Metoprolol;Sildenafil
6 Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease Recruiting NCT02947750 Phase 2 6R-BH4
7 Functional Sympatholysis and Exercise Intolerance in Chronic Kidney Disease Recruiting NCT02411773 Phase 2 Sodium Bicarbonate;Placebo
8 Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus (Exercise SLE Pilot). Completed NCT03186794 Phase 1
9 Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development Completed NCT01395342 Phase 1
10 Study of Cardiovascular Responses to Static and Dynamic Exercise in Isolated Systolic Hypertension Unknown status NCT02270216
11 The Link Between the Clinical Resting Heart Rate and Sympathetic Overactivation Unknown status NCT02315313
12 Effect of Rebound Exercises and Circuit Training on Musculoskeletal Pain, Selected Biochemical and Psychosocial Parameters Among Individuals With Type 2 Diabetics Unknown status NCT03200795
13 Determinants of Chronotropic Incompetence in Patients With Heart Failure and a Preserved Ejection Fraction (HFpEF) Completed NCT02524145 Dexmedetomidine;Glycopyrrolate;Isoproterenol
14 The Village Interactive Training and Learning Study Completed NCT01709799
15 Atrial Function and Supraventricular Arrhythmia of the Veteran Athlete. Completed NCT03665324
16 Feasibility and Agreement of Remote Evaluation of Resting Heart Rate and Heart Rate Variability in Survivors of Hodgkin Lymphoma Treated With Chest Radiation (PILOT STUDY-SURVIVOR) Completed NCT03838627
17 Resting Heart Rate Variability as a Predictor of Coping Strategies and Responsiveness to a Brief Online Intervention During Forced Quarantine Completed NCT04382560
18 Observational Non-interventional Study - Epidemiological Survey "AchievemenT of Goal Resting HEart Rate on Beta-blockers in Patients With Stable angiNA and Hypertension in Routine Practice" Completed NCT01321242
19 Effect of Relaxing Music on Blood Pressure and Resting Heart Rate Among Pre-hypertensive Young Adults Completed NCT04147507
20 Neural Control and Cardiac-Vascular Function in Women With PTSD Completed NCT03929939
21 Heart Rate Changes in Response to an Exercise Test and to a High Intensity Interval Training Session in Subjects With Normoglycaemic, Prediabetes, and Type 2 Diabetes Mellitus State Completed NCT03917576
22 Assessing Performance Status in Cancer Patients Using Cardiopulmonary Exercise Testing and Wearable Data Generation: A Prospective Observational Study Completed NCT02844400
23 Promotion of Coronary Collateral Function by Ivabradine-Induced Bradycardia in Patients With Coronary Artery Disease Completed NCT01039389 Ivabradine;Placebo
24 Effect of Aerobic Interval Training Combined With Vitamin D Supplement on Functional Capacity and Perceived Myalgia in Middle Aged Obese Women Completed NCT04319289 Vitamin D supplementation only
25 Cardiopulmonary Fitness, Lung Function, Muscular Oxygen Saturation, and Quality of Life in Patients With Type 1 Diabetes Mellitus Completed NCT01727661
26 Clinical Usefulness of Monitoring Heart Rate Using Wearable Devices in the Patients of Graves' Disease Who Discontinue Anti-thyroid Drugs Recruiting NCT04333342
27 Remote Physiologic Monitoring of Resident Wellness and Burnout Active, not recruiting NCT04304703
28 The Effect of Exercise on Muscle Dysfunction in Cystinosis Not yet recruiting NCT04071548
29 Remote Physiologic Monitoring to Detect Inflammatory Bowel Disease (IBD) Flares: A Feasibility Study Not yet recruiting NCT04333810
30 An Exploratory Trial of a Multimodal Treatment Strategy for Cancer Cachexia Terminated NCT00625742 Melatonin;Atenolol;Ibuprofen
31 High Intensity Interval Training in Heart Failure: The Gold Standard of Future Patient Care Withdrawn NCT03032081
32 Use of Prophylactic Beta Blockade to Prevent Peri-extubation Cardiac Ischemia and Congestive Heart Failure Withdrawn NCT00563238 Metoprolol

Search NIH Clinical Center for Resting Heart Rate, Variation in

Genetic Tests for Resting Heart Rate, Variation in

Genetic tests related to Resting Heart Rate, Variation in:

# Genetic test Affiliating Genes
1 Resting Heart Rate 29 ADRB1

Anatomical Context for Resting Heart Rate, Variation in

MalaCards organs/tissues related to Resting Heart Rate, Variation in:

40
Heart, Breast, Endothelial, Thyroid, Brain, Kidney, Spinal Cord

Publications for Resting Heart Rate, Variation in

Articles related to Resting Heart Rate, Variation in:

(show top 50) (show all 3887)
# Title Authors PMID Year
1
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. 6 54 61 57
11854867 2002
2
Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. 57 61
12189495 2002
3
The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study) 61 57
10637085 2000
4
Heart rate and cardiovascular mortality: the Framingham Study. 61 57
3591616 1987
5
Several common variants modulate heart rate, PR interval and QRS duration. 57
20062063 2010
6
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. 57
20031603 2009
7
Heritability of heart rate variability: the Framingham Heart Study. 57
10226089 1999
8
Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. 54 61
16907703 2006
9
Association between ghrelin and cardiovascular indexes in healthy obese and lean men. 54 61
14678289 2004
10
Principal components of fitness: relationship to physical activity and lifestyle. 61 54
8081323 1994
11
Football can tackle type 2 diabetes: a systematic review of the health effects of recreational football practice in individuals with prediabetes and type 2 diabetes. 61
32567951 2021
12
Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys. 61
33556713 2021
13
Association of Positive Emotion Dysregulation to Resting Heart Rate Variability: The Influence of Positive Affect Intensity. 61
33518872 2021
14
Cardioautonomic control in healthy singleton and twin pregnancies. 61
33356983 2021
15
Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. 61
33569926 2021
16
Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study. 61
33526428 2021
17
Cardiac Autonomic Function and Psychological Characteristics of Heterosexual Female Perpetrators of Intimate Partner Physical Aggression. 61
29806562 2021
18
The ROS scavenger PDTC affects adaptation to treadmill running in mice: distinct effects on murine body mass, resting heart rate and skeletal muscle fiber type composition. 61
33737459 2021
19
Resting Heart Rate as an Important Predictor of Mortality and Morbidity in Ambulatory Patients With Heart Failure: A Systematic Review and Meta-Analysis. 61
33171294 2021
20
Resting Heart Rate as a Predictor of Cancer Mortality: A Systematic Review and Meta-Analysis. 61
33806038 2021
21
Covariate effects of resting heart rate variability on affective ratings and startle reflex during cognitive reappraisal of negative emotions. 61
33761842 2021
22
Prognostic Value of Reduced Heart Rate Reserve during Exercise in Hypertrophic Cardiomyopathy. 61
33805111 2021
23
Autonomic dysregulation as an early pathologic feature of Huntington Disease. 61
33571915 2021
24
Cardiovascular symptoms affect the patterns of habitual coffee consumption. 61
33711095 2021
25
Impact of COVID-19 lockdown in patients with implantable cardioverter and cardiac resynchronization therapy defibrillators: insights from daily remote monitoring transmissions. 61
33779824 2021
26
Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. 61
33402367 2021
27
Determinants and consequences of heart rate and stroke volume response to exercise in patients with heart failure and preserved ejection fraction. 61
33686716 2021
28
Changes in sleep duration, timing, and variability during the COVID-19 pandemic: Large-scale Fitbit data from 6 major US cities. 61
33771534 2021
29
Effect of early use of ivabradine on left ventricular remodeling after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: A pilot test. 61
33368951 2021
30
Cardiovascular risk factors in extended family members and birthweight in offspring. 61
33691829 2021
31
Altered regulation of negative affect in patients with fibromyalgia: A diary study. 61
33259659 2021
32
Heart rate recovery is useful for evaluating the recovery of exercise tolerance in patients with heart failure and atrial fibrillation. 61
33783632 2021
33
Physical capacities and leisure activities are related with cognitive functions in older adults. 61
33728840 2021
34
Relationship Between Heart Rate at Discharge and Long-Term Outcomes of Surgically Treated Patients With Type A Acute Aortic Dissections. 61
33790141 2021
35
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. 61
33719582 2021
36
Prevalence and associated factors of electrocardiographic left ventricular hypertrophy in a rural community, central Thailand. 61
33782536 2021
37
Influence of Dietary Nitrate Supplementation on Physical Performance and Body Composition Following Offseason Training in Division I Athletes. 61
33754923 2021
38
Cardiovascular Drug Therapy during Interstage After Hybrid Approach: A Single-Center Experience in 51 Newborns with Hypoplastic Left Heart. 61
33713024 2021
39
Heart rate, intelligence in adolescence, and Parkinson's disease later in life. 61
33675447 2021
40
Association of Psychosocial Factors With Short-Term Resting Heart Rate Variability: The Atherosclerosis Risk in Communities Study. 61
33631952 2021
41
One-year change in resting heart rate and subsequent risk of hypertension in healthy Chinese adults. 61
32701565 2021
42
Resting heart rate predicts all-cause mortality in sub-Saharan African patients with heart failure: a prospective analysis from the Douala Heart failure registry (Do-HF). 61
33708483 2021
43
Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study. 61
33632724 2021
44
Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass. 61
33557704 2021
45
Cardiac adaptations to 60 day head-down-tilt bed rest deconditioning. Findings from the AGBRESA study. 61
33191629 2021
46
Supraventricular Tachycardia and Postural Orthostatic Tachycardia Syndrome Overlap: A Retrospective Study. 61
33654569 2021
47
Are Trait Emotional Competencies and Heart Rate Variability Linked to Mental Health of Coronary Heart Disease Patients? 61
31910715 2021
48
RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart. 61
33574422 2021
49
Autonomic Cardiovascular Alterations in Chronic Kidney Disease: Effects of Dialysis, Kidney Transplantation, and Renal Denervation. 61
33582896 2021
50
High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid. 61
33582757 2021

Variations for Resting Heart Rate, Variation in

ClinVar genetic disease variations for Resting Heart Rate, Variation in:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ADRB1 NM_000684.3(ADRB1):c.145A>G (p.Ser49Gly) SNV association 17747 rs1801252 GRCh37: 10:115804036-115804036
GRCh38: 10:114044277-114044277

Expression for Resting Heart Rate, Variation in

Search GEO for disease gene expression data for Resting Heart Rate, Variation in.

Pathways for Resting Heart Rate, Variation in

Pathways related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 ADRB2 ADRB1 ADRA2B
2
Show member pathways
11.83 ADRB2 ADRB1 ADRA2B
3 11.62 ADRB2 ADRB1
4 11.54 ADRB2 ADRB1
5 11.21 ADRB2 ADRB1
6
Show member pathways
11.17 ADRB2 ADRB1 ADRA2B
7 11.08 ADRB2 ADRB1
8 11 ADRB2 ADRB1
9 10.16 ADRB2 ADRB1 ADRA2B

GO Terms for Resting Heart Rate, Variation in

Biological processes related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.52 ADRB2 ADRA2B
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.51 ADRB2 ADRB1
3 positive regulation of cold-induced thermogenesis GO:0120162 9.49 ADRB2 ADRB1
4 activation of adenylate cyclase activity GO:0007190 9.48 ADRB2 ADRB1
5 response to cold GO:0009409 9.46 ADRB2 ADRB1
6 brown fat cell differentiation GO:0050873 9.43 ADRB2 ADRB1
7 regulation of smooth muscle contraction GO:0006940 9.4 ADRB2 ADRA2B
8 adrenergic receptor signaling pathway GO:0071875 9.37 ADRB2 ADRA2B
9 diet induced thermogenesis GO:0002024 9.32 ADRB2 ADRB1
10 negative regulation of multicellular organism growth GO:0040015 9.26 ADRB2 ADRB1
11 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.16 ADRB2 ADRB1
12 heat generation GO:0031649 8.96 ADRB2 ADRB1
13 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.8 ADRB2 ADRB1 ADRA2B

Molecular functions related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.13 ADRB2 ADRB1 ADRA2B
2 adrenergic receptor activity GO:0004935 8.8 ADRB2 ADRB1 ADRA2B

Sources for Resting Heart Rate, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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