MCID: RST023
MIFTS: 42

Resting Heart Rate, Variation in

Categories: Genetic diseases

Aliases & Classifications for Resting Heart Rate, Variation in

MalaCards integrated aliases for Resting Heart Rate, Variation in:

Name: Resting Heart Rate, Variation in 57
Resting Heart Rate 57 29 55 6 40
Rhr 57

Classifications:



External Ids:

OMIM 57 607276

Summaries for Resting Heart Rate, Variation in

MalaCards based summary : Resting Heart Rate, Variation in, also known as resting heart rate, is related to myocardial infarction and aging. An important gene associated with Resting Heart Rate, Variation in is ADRB1 (Adrenoceptor Beta 1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and NFAT and Cardiac Hypertrophy. The drugs Carvedilol and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney.

Description from OMIM: 607276

Related Diseases for Resting Heart Rate, Variation in

Diseases related to Resting Heart Rate, Variation in via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.3 ADRA2B ADRB1 ADRB2
2 aging 10.3
3 arteries, anomalies of 10.2
4 coronary artery anomaly 10.2
5 heart disease 10.1
6 diabetes mellitus 10.0
7 atrial fibrillation 10.0
8 ischemic heart disease 9.9
9 vascular disease 9.9
10 ocular hypotension 9.9 ADRB1 ADRB2
11 coronary heart disease 1 9.8
12 brain injury 9.8
13 dilated cardiomyopathy 9.8
14 autonomic neuropathy 9.8
15 panic disorder 9.8
16 neuropathy 9.8
17 depression 9.8
18 meningococcal infection 9.8 ADRB1 ADRB2
19 aortic coarctation 9.7 ADRB1 ADRB2
20 cardiac conduction defect 9.7
21 diabetes mellitus, noninsulin-dependent 9.7
22 systemic lupus erythematosus 9.7
23 pulmonary hypertension, primary, 1 9.7
24 rheumatoid arthritis 9.7
25 anxiety 9.7
26 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 9.7
27 peripartum cardiomyopathy 9.7
28 angina pectoris 9.7
29 pulmonary hypertension 9.7
30 arthritis 9.7
31 chronic kidney failure 9.7
32 colorectal adenoma 9.7
33 traumatic brain injury 9.7
34 diabetic autonomic neuropathy 9.7
35 crimean-congo hemorrhagic fever 9.7
36 epilepsy 9.7
37 vaginitis 9.7
38 kidney disease 9.7
39 adenoma 9.7
40 lupus erythematosus 9.7
41 chronic thromboembolic pulmonary hypertension 9.7
42 hemorrhagic fever 9.7
43 endotheliitis 9.7
44 osteoporotic fracture 9.7
45 congestive heart failure 9.3 ADRB1 ADRB2
46 orthostatic intolerance 9.3 ADRA2B ADRB1 ADRB2
47 hypertension, essential 9.2 ADRA2B ADRB1 ADRB2
48 body mass index quantitative trait locus 11 9.0 ADRB1 ADRB2 LEPQTL1

Graphical network of the top 20 diseases related to Resting Heart Rate, Variation in:



Diseases related to Resting Heart Rate, Variation in

Symptoms & Phenotypes for Resting Heart Rate, Variation in

Clinical features from OMIM:

607276

Drugs & Therapeutics for Resting Heart Rate, Variation in

Drugs for Resting Heart Rate, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 201)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
3
Bisoprolol Approved Phase 4 66722-44-9 2405
4
Atenolol Approved Phase 4,Not Applicable 29122-68-7 2249
5
Exenatide Approved, Investigational Phase 4,Not Applicable 141758-74-9 15991534
6
Liraglutide Approved Phase 4 204656-20-2 44147092
7
Cilnidipine Approved, Investigational Phase 4 132203-70-4 5282138
8
Nifedipine Approved Phase 4 21829-25-4 4485
9
Citalopram Approved Phase 4 59729-33-8 2771
10 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
11 Adrenergic alpha-1 Receptor Antagonists Phase 4
12 Adrenergic alpha-Antagonists Phase 4
13 Adrenergic Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
14 Adrenergic beta-1 Receptor Antagonists Phase 4,Not Applicable
15 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
16 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Not Applicable
17 Antihypertensive Agents Phase 4,Phase 2,Phase 3,Not Applicable
18 Autonomic Agents Phase 4,Phase 2,Phase 1,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
21 Sympatholytics Phase 4,Not Applicable
22 Vasodilator Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Calcium, Dietary Phase 4,Phase 2,Not Applicable
24 Dipeptidyl-Peptidase IV Inhibitors Phase 4
25
Fenbendazole Phase 4 43210-67-9 3334
26 glucagon Phase 4
27 Glucagon-Like Peptide 1 Phase 4
28 HIV Protease Inhibitors Phase 4
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
30 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
32 Hypoglycemic Agents Phase 4,Phase 2,Not Applicable
33 Incretins Phase 4,Not Applicable
34 insulin Phase 4,Not Applicable
35 Insulin, Globin Zinc Phase 4,Not Applicable
36 omega-N-Methylarginine Phase 4
37
protease inhibitors Phase 4
38 Sitagliptin Phosphate Phase 4
39 calcium channel blockers Phase 4,Phase 2
40 Tocolytic Agents Phase 4,Phase 2
41 Antidepressive Agents Phase 4
42 Antidepressive Agents, Second-Generation Phase 4
43 Antiparkinson Agents Phase 4
44 Cholinergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
45 Cholinergic Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
46 Muscarinic Antagonists Phase 4,Not Applicable
47 Neurotransmitter Uptake Inhibitors Phase 4
48 Parasympatholytics Phase 4,Phase 2,Phase 1
49 Psychotropic Drugs Phase 4,Not Applicable
50 Serotonin Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 194)
# Name Status NCT ID Phase Drugs
1 Rate Control in Atrial Fibrillation Unknown status NCT02251509 Phase 4 Carvedilol;Metoprolol tartrate
2 Ivabradine in Hemodialysed Patients With Increased Heart Rate Unknown status NCT01364077 Phase 4 Ivabradine;Placebo
3 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
4 A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension Completed NCT01251146 Phase 4 Bisoprolol;Atenolol
5 SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies Completed NCT01744236 Phase 4 Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
6 Evaluation of Succinate Metoprolol on Heart Rate in the Stable Angina Patients Completed NCT01213173 Phase 4 Succinate Metoprolol (Betaloc ZOK®);Succinate Metoprolol (Betaloc ZOK®)
7 The Effects of Cilnidipine on Metabolic Syndrome Improvement Completed NCT00325936 Phase 4 Cilnidipine
8 Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure Completed NCT02903225 Phase 4
9 Responses of Myocardial Ischemia to Escitalopram Treatment Completed NCT00574847 Phase 4 Escitalopram;Placebo
10 Efficacy of Oral Bisoprolol on Heart Rate Reduction in Chinese Chronic Heart Failure Subjects Recruiting NCT03026088 Phase 4 Bisoprolol
11 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
12 Dietary Intervention of Stress-Induced Neurovegetative Disorders With a Specific Amino Acid Composition (asn01) Completed NCT01425983 Phase 3
13 Effect of Transcranial Direct Current Stimulation Associated With Aerobic Exercise Training for Patients With Fibromyalgia Completed NCT02358902 Phase 2, Phase 3
14 A Home-based Physical Activity Intervention in Breast Cancer Survivors Completed NCT02408107 Phase 3
15 Physical Fitness Training in Subacute Stroke (PHYS-Stroke) Completed NCT01953549 Phase 3
16 CHANGE -it is About Life Completed NCT01585493 Phase 3
17 Efficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101) Completed NCT00163293 Phase 3 Ciclesonide;Placebo
18 Propranolol in Severely Burned Children Recruiting NCT01957449 Phase 2, Phase 3 Propranolol;Placebo
19 Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC) Recruiting NCT02584439 Phase 3 ivabradine;lactose capsule (placebo)
20 Protective Effects of Propranolol in Adults Recruiting NCT01902810 Phase 2, Phase 3 Propranolol;Placebo
21 Fenofibrate and Propranolol in Burn Patients Recruiting NCT02452255 Phase 2, Phase 3 Fenofibrate;Placebo;Propranolol
22 The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation Recruiting NCT03018041 Phase 3 Omacor;Placebo Oral Capsule
23 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Recruiting NCT03038594 Phase 2, Phase 3 Somatropin;0.09% Saline Solution
24 Environmental Strategies & Behavior Change to Reduce Overeating in Obese Children Unknown status NCT01221220 Phase 2
25 Clinic, Family & Community Collaboration to Treat Overweight and Obese Children (Stanford GOALS) Unknown status NCT01642836 Phase 2
26 Heart Rate Variability in Response to Metformin Challenge Completed NCT02500628 Phase 2 Metformin
27 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity of Hemiplegics Completed NCT01569386 Phase 2
28 Promoting Wellbeing for Women With Depression: A Pragmatic Randomised Controlled Trial (RCT) of an Exercise Programme Completed NCT00546221 Phase 2
29 Sports to Prevent Obesity: Feasibility and Pilot RCT Completed NCT00186173 Phase 1, Phase 2
30 Safety Study Using GSK573719 And Tiotropium In Patients With Chronic Obstructive Pulmonary Disease Completed NCT00515502 Phase 2 GSK573719;Tiotropium
31 Central Meditation and Imagery Therapy for Augmentation of Borderline Personality Disorder Treatment Completed NCT02125942 Phase 1, Phase 2
32 Obesity Prevention for Pre-Adolescents Completed NCT00185978 Phase 2
33 Study to Promote Physical Activity Among Overweight Persons Completed NCT00313040 Phase 1, Phase 2
34 Effect of Exercise on Renal Function in Predialysis Completed NCT02155036 Phase 1, Phase 2
35 Beta Blocker Therapy in Mild to Moderate Asthmatics Completed NCT01544634 Phase 2 Propranolol;Placebo;Qvar 50;Qvar 100
36 Study of the Clinical Activity, Safety, and Tolerability of SRT2104 in Subjects With Moderate to Severe Plaque-Type Psoriasis Completed NCT01154101 Phase 2 Placebo;SRT2104
37 Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam Completed NCT01940250 Phase 2 Magnesium Sulphate;Sterile water
38 Sympatholysis in Chronic Kidney Disease Recruiting NCT02411773 Phase 2 Sodium Bicarbonate;Placebo
39 Neurovascular Transduction During Exercise in Chronic Kidney Disease Recruiting NCT02947750 Phase 2 6R-BH4
40 Efficacy and Safety of Mycophenolate Mofetil in subjectswithSjogren's Syndrome Enrolling by invitation NCT02691949 Phase 2 Mycophenolate mofetil
41 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Not yet recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
42 South Asian Women & Yoga Education Study Unknown status NCT01667835 Phase 1
43 Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development Completed NCT01395342 Phase 1
44 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-42721458 in Healthy Male Participants Completed NCT01840501 Phase 1 JNJ-42721458 (single dose);JNJ-42721458 (multiple doses);Placebo (single dose);Placebo (multiple doses)
45 Effect of GSK1160724 In Healthy Volunteers Completed NCT00555022 Phase 1 GSK1160724;Tiotropium bromide;Placebo
46 Ibuprofen and Pseudoephedrine Comparative Pharmacokinetic Study Completed NCT03184766 Phase 1 Test Nurofen Cold and Flu®, Ibuprofen and pseudoephedrine liquid capsules;Comparator 1 Nurofen Cold and Flu®, ibuprofen and pseudoephedrine tablets;Comparator 2 Nurofen Immedia 200 mg Weichkapseln, ibuprofen liquid capsules
47 Ibuprofen Bioavailability Study Completed NCT03180879 Phase 1 Test - RB ibuprofen acid orodispersible tablets;Reference - RB Nurofen ibuprofen acid tablets;Comparator - Dolormin ibuprofen lysine tablets
48 Aerobic Exercise in Women With Systemic Lupus Erythematosus Recruiting NCT03186794 Phase 1
49 The Safety and Tolerability of Pirfenidone for BOS After HCT Recruiting NCT03315741 Phase 1 Pirfenidone 267 MG [Esbriet]
50 Safety, Tolerability and Pharmacokinetics of AZD1775 Plus MEDI4736 in Patients With Advanced Solid Tumours Recruiting NCT02617277 Phase 1 AZD1775;MEDI4736

Search NIH Clinical Center for Resting Heart Rate, Variation in

Genetic Tests for Resting Heart Rate, Variation in

Genetic tests related to Resting Heart Rate, Variation in:

# Genetic test Affiliating Genes
1 Resting Heart Rate 29 ADRB1

Anatomical Context for Resting Heart Rate, Variation in

MalaCards organs/tissues related to Resting Heart Rate, Variation in:

41
Heart, Testes, Kidney, Brain, Bone, Endothelial, Prefrontal Cortex

Publications for Resting Heart Rate, Variation in

Articles related to Resting Heart Rate, Variation in:

(show top 50) (show all 238)
# Title Authors Year
1
Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. ( 29499053 )
2018
2
High Resting Heart Rate and High BMI Predicted Severe Coronary Atherosclerosis Burden in Patients With Stable Angina Pectoris by SYNTAX Score. ( 28635302 )
2017
3
Resting Heart Rate Variability, Facets of Rumination and Trait Anxiety: Implications for the Perseverative Cognition Hypothesis. ( 29163100 )
2017
4
Prognostic significance of exercise capacity and resting heart rate: Comparison between atrial fibrillation and sinus rhythm. ( 26569363 )
2015
5
Low systolic blood pressure and high resting heart rate as predictors of outcome in patients with peripartum cardiomyopathy. ( 25966297 )
2015
6
Low resting heart rates are associated with new-onset atrial fibrillation in patients with vascular disease: results of the ONTARGET/TRANSCEND studies. ( 25872921 )
2015
7
Analysis of resting heart rate and clinical characteristics in outpatients with stable coronary artery disease in Turkey: PULSE study. ( 24146273 )
2014
8
Resting heart rate and the association of physical fitness with carotid artery stiffness. ( 24029163 )
2014
9
Insight into genetic determinants of resting heart rate. ( 24680774 )
2014
10
AchievemenT of target resting HEart rate on beta-blockers in patients with stable angiNA and hypertension (ATHENA) in routine clinical practice in Russia. ( 24400847 )
2014
11
Resting heart rate as a marker for identifying the risk of undiagnosed type 2 diabetes mellitus: a cross-sectional survey. ( 25297916 )
2014
12
Resting heart rate in children with crimean-congo hemorrhagic Fever: a tool to identify patients at risk? ( 24359422 )
2014
13
Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure. ( 24142684 )
2014
14
Aggressive behavior: an alternative model of resting heart rate and sensation seeking. ( 23996463 )
2014
15
Elevated resting heart rate and reduced orthostatic tolerance in obese humans. ( 24292891 )
2013
16
Resting heart rate is associated with nonproliferative retinopathy in normoalbuminuric type 1 diabetic patients. ( 23889721 )
2013
17
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. ( 23250912 )
2013
18
Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects. ( 24237764 )
2013
19
Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording. ( 24329133 )
2013
20
Affective instability in daily life is predicted by resting heart rate variability. ( 24312315 )
2013
21
The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. ( 23858001 )
2013
22
Importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness. ( 24144645 )
2013
23
Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving I^-blocker therapy: data from the HF-ACTION trial. ( 23315907 )
2013
24
Resting heart rate and physical activity as risk factors for lone atrial fibrillation: a prospective study of 309,540 men and women. ( 23749790 )
2013
25
Effects of stair-climbing on balance, gait, strength, resting heart rate, and submaximal endurance in healthy seniors. ( 24033611 )
2013
26
Atrial aspiration from pulmonary and caval veins is caused by ventricular contraction and secures 70% of the total stroke volume independent of resting heart rate and heart size. ( 23522018 )
2013
27
Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the Copenhagen Male Study. ( 23595657 )
2013
28
Resting heart rate: its correlations and potential for screening metabolic dysfunctions in adolescents. ( 23560541 )
2013
29
Resting heart rate is a predictor of mortality in COPD. ( 23143550 )
2013
30
Association Between Resting Heart Rate and Inflammatory Biomarkers (High-Sensitivity C-Reactive Protein, Interleukin-6, and Fibrinogen) (from the Multi-Ethnic Study of Atherosclerosis). ( 24393259 )
2013
31
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. ( 23183192 )
2013
32
Association of resting heart rate with carotid and aortic arterial stiffness: multi-ethnic study of atherosclerosis. ( 23836802 )
2013
33
The benefits of ivabradine are independent of resting heart rate. ( 23668736 )
2013
34
Resting heart rate in children and adolescents: association with blood pressure, exercise and obesity. ( 23422162 )
2013
35
The risk of resting heart rate on vascular events and mortality in vascular patients. ( 23305859 )
2013
36
Protective role of resting heart rate on all-cause and cardiovascular disease mortality. ( 24290115 )
2013
37
The relationship between resting heart rate variability and erectile tumescence among men with normal erectile function. ( 23802770 )
2013
38
Resting Heart Rate, Vagal Tone, and Reactive and Proactive Aggression in Chinese Children. ( 23959546 )
2013
39
Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate. ( 23192947 )
2013
40
Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic dysfunction and heart rate-modulating drugs. ( 23680897 )
2013
41
Resting Heart Rate as Predictor for Left Ventricular Dysfunction and Heart Failure: The Multi-Ethnic Study of Atherosclerosis. ( 24412444 )
2013
42
Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy. ( 23587802 )
2013
43
The association and predictive value analysis of metabolic syndrome combined with resting heart rate on cardiovascular autonomic neuropathy in the general Chinese population. ( 24238358 )
2013
44
Resting heart rate and outcomes in patients with cardiovascular disease: where do we currently stand? ( 22954325 )
2013
45
Resting heart rate and the risk of heart failure in healthy adults: the Rotterdam Study. ( 23599310 )
2013
46
Resting heart rate predicts metabolic syndrome in apparently healthy non-obese Japanese men. ( 23838790 )
2013
47
Response to importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness. ( 24369029 )
2013
48
Heart rate distribution and predictors of resting heart rate after initiation of beta-blocker treatment in patients with coronary artery disease: REsults of Sympathetic Evaluation And Research of China (RESEARCH) study. ( 24034090 )
2013
49
The relationship between resting heart rate and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). ( 21763655 )
2012
50
Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease. ( 22144667 )
2012

Variations for Resting Heart Rate, Variation in

Expression for Resting Heart Rate, Variation in

Search GEO for disease gene expression data for Resting Heart Rate, Variation in.

Pathways for Resting Heart Rate, Variation in

Pathways related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 ADRB1 ADRB2 TTF2
2
Show member pathways
12.32 ADRA2B ADRB1 ADRB2
3
Show member pathways
12.14 ADRA2B ADRB1 ADRB2
4
Show member pathways
11.78 ADRB1 ADRB2
5
Show member pathways
11.71 ADRB1 ADRB2
6 11.64 ADRB1 ADRB2
7 11.56 ADRB1 ADRB2
8
Show member pathways
11.19 ADRA2B ADRB1 ADRB2
9 11.18 ADRB1 ADRB2
10 11 ADRB1 ADRB2
11 10.89 ADRB1 ADRB2
12 10.16 ADRA2B ADRB1 ADRB2

GO Terms for Resting Heart Rate, Variation in

Biological processes related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.65 ADRA2B ADRB1 ADRB2
2 positive regulation of MAPK cascade GO:0043410 9.54 ADRA2B ADRB2
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.52 ADRB1 ADRB2
4 response to cold GO:0009409 9.51 ADRB1 ADRB2
5 activation of adenylate cyclase activity GO:0007190 9.49 ADRB1 ADRB2
6 brown fat cell differentiation GO:0050873 9.46 ADRB1 ADRB2
7 regulation of smooth muscle contraction GO:0006940 9.43 ADRA2B ADRB2
8 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.43 ADRA2B ADRB1 ADRB2
9 negative regulation of multicellular organism growth GO:0040015 9.4 ADRB1 ADRB2
10 adrenergic receptor signaling pathway GO:0071875 9.37 ADRA2B ADRB2
11 diet induced thermogenesis GO:0002024 9.32 ADRB1 ADRB2
12 heat generation GO:0031649 9.16 ADRB1 ADRB2
13 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 8.96 ADRB1 ADRB2
14 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.8 ADRA2B ADRB1 ADRB2

Molecular functions related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.5 ADRA2B ADRB1 ADRB2
2 obsolete signal transducer activity GO:0004871 9.43 ADRA2B ADRB1 ADRB2
3 norepinephrine binding GO:0051380 9.16 ADRB1 ADRB2
4 adrenergic receptor activity GO:0004935 9.13 ADRA2B ADRB1 ADRB2
5 epinephrine binding GO:0051379 8.8 ADRA2B ADRB1 ADRB2

Sources for Resting Heart Rate, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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