RHR
MCID: RST023
MIFTS: 42

Resting Heart Rate, Variation in (RHR)

Categories: Genetic diseases

Aliases & Classifications for Resting Heart Rate, Variation in

MalaCards integrated aliases for Resting Heart Rate, Variation in:

Name: Resting Heart Rate, Variation in 57
Resting Heart Rate 57 29 55 6 40
Rhr 57

Classifications:



External Ids:

OMIM 57 607276

Summaries for Resting Heart Rate, Variation in

MalaCards based summary : Resting Heart Rate, Variation in, also known as resting heart rate, is related to coronary artery anomaly and myocardial infarction. An important gene associated with Resting Heart Rate, Variation in is ADRB1 (Adrenoceptor Beta 1), and among its related pathways/superpathways are NFAT and Cardiac Hypertrophy and Aldosterone synthesis and secretion. The drugs Metoprolol and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney.

Description from OMIM: 607276

Related Diseases for Resting Heart Rate, Variation in

Diseases related to Resting Heart Rate, Variation in via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.3 ADRB1 ADRB2
2 myocardial infarction 29.8 ADRA2B ADRB1 ADRB2
3 congestive heart failure 29.7 ADRB1 ADRB2
4 hypertension, essential 29.3 ADRA2B ADRB1 ADRB2
5 atrial fibrillation 10.4
6 arteries, anomalies of 10.3
7 diabetes mellitus 10.2
8 diabetes mellitus, noninsulin-dependent 10.2
9 heart disease 10.2
10 vascular disease 10.1
11 breast cancer 10.0
12 systemic lupus erythematosus 10.0
13 anxiety 10.0
14 ischemic heart disease 10.0
15 autonomic neuropathy 10.0
16 neuropathy 10.0
17 lupus erythematosus 10.0
18 ocular hypotension 10.0 ADRB1 ADRB2
19 meningococcal infection 10.0 ADRB1 ADRB2
20 atherosclerosis susceptibility 9.9
21 coronary heart disease 1 9.9
22 brain injury 9.9
23 dilated cardiomyopathy 9.9
24 panic disorder 9.9
25 depression 9.9
26 aortic coarctation 9.9 ADRB1 ADRB2
27 cardiac conduction defect 9.8
28 pulmonary hypertension, primary, 1 9.8
29 rheumatoid arthritis 9.8
30 schizophrenia 9.8
31 small cell cancer of the lung 9.8
32 tetralogy of fallot 9.8
33 lung cancer 9.8
34 graves disease 1 9.8
35 pulmonary disease, chronic obstructive 9.8
36 human immunodeficiency virus type 1 9.8
37 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 9.8
38 peripartum cardiomyopathy 9.8
39 aortic valve disease 2 9.8
40 angina pectoris 9.8
41 pulmonary hypertension 9.8
42 arthritis 9.8
43 chronic kidney failure 9.8
44 colorectal adenoma 9.8
45 traumatic brain injury 9.8
46 glucose intolerance 9.8
47 diabetic autonomic neuropathy 9.8
48 crimean-congo hemorrhagic fever 9.8
49 disease of mental health 9.8
50 epilepsy 9.8

Graphical network of the top 20 diseases related to Resting Heart Rate, Variation in:



Diseases related to Resting Heart Rate, Variation in

Symptoms & Phenotypes for Resting Heart Rate, Variation in

Clinical features from OMIM:

607276

Drugs & Therapeutics for Resting Heart Rate, Variation in

Drugs for Resting Heart Rate, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 37350-58-6, 51384-51-1 4171
2
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
3
Bisoprolol Approved Phase 4 66722-44-9 2405
4
Atenolol Approved Phase 4,Not Applicable 29122-68-7 2249
5
Liraglutide Approved Phase 4 204656-20-2 44147092
6
Exenatide Approved, Investigational Phase 4,Not Applicable 141758-74-9 15991534
7
Nifedipine Approved Phase 4 21829-25-4 4485
8
Citalopram Approved Phase 4 59729-33-8 2771
9
Cilnidipine Investigational Phase 4 132203-70-4 5282138
10 Vasodilator Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
11 Antihypertensive Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
12 Adrenergic alpha-1 Receptor Antagonists Phase 4
13 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
14 Adrenergic alpha-Antagonists Phase 4,Phase 1
15 Sympatholytics Phase 4,Not Applicable
16 Adrenergic beta-1 Receptor Antagonists Phase 4,Not Applicable
17 Adrenergic Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Autonomic Agents Phase 4,Phase 2,Phase 1,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
22 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
24 Cholinergic Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
25 Insulin, Globin Zinc Phase 4,Phase 2,Not Applicable
26 Sitagliptin Phosphate Phase 4
27
protease inhibitors Phase 4
28 Hypoglycemic Agents Phase 4,Phase 2,Not Applicable
29 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
30 Incretins Phase 4,Not Applicable
31 Glucagon-Like Peptide 1 Phase 4
32 omega-N-Methylarginine Phase 4
33 glucagon Phase 4
34 Dipeptidyl-Peptidase IV Inhibitors Phase 4
35 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
36 insulin Phase 4,Phase 2,Not Applicable
37
Fenbendazole Phase 4 43210-67-9 3334
38 HIV Protease Inhibitors Phase 4
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
40 Tocolytic Agents Phase 4,Phase 2
41 calcium channel blockers Phase 4,Phase 3,Phase 2
42 Serotonin Agents Phase 4
43 Psychotropic Drugs Phase 4,Not Applicable
44 Parasympatholytics Phase 4,Phase 2,Phase 1
45 Cholinergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
46 Neurotransmitter Uptake Inhibitors Phase 4
47 Muscarinic Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
48 Antidepressive Agents, Second-Generation Phase 4
49 Antidepressive Agents Phase 4
50 Serotonin Uptake Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 227)
# Name Status NCT ID Phase Drugs
1 Rate Control in Atrial Fibrillation Unknown status NCT02251509 Phase 4 Carvedilol;Metoprolol tartrate
2 Ivabradine in Hemodialysed Patients With Increased Heart Rate Unknown status NCT01364077 Phase 4 Ivabradine;Placebo
3 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
4 A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension Completed NCT01251146 Phase 4 Bisoprolol;Atenolol
5 Efficacy of Oral Bisoprolol on Heart Rate Reduction in Chinese Chronic Heart Failure Subjects Recruiting NCT03026088 Phase 4 Bisoprolol
6 Ivabradine in Stage D Heart Failure Patients on Chronic Inotropes Not yet recruiting NCT03631654 Phase 4 Ivabradine;Placebos
7 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
8 SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies Completed NCT01744236 Phase 4 Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
9 Evaluation of Succinate Metoprolol on Heart Rate in the Stable Angina Patients Completed NCT01213173 Phase 4 Succinate Metoprolol (Betaloc ZOK®);Succinate Metoprolol (Betaloc ZOK®)
10 The Effects of Cilnidipine on Metabolic Syndrome Improvement Completed NCT00325936 Phase 4 Cilnidipine
11 Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure Completed NCT02903225 Phase 4
12 Responses of Myocardial Ischemia to Escitalopram Treatment Completed NCT00574847 Phase 4 Escitalopram;Placebo
13 Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC) Unknown status NCT02584439 Phase 3 ivabradine;lactose capsule (placebo)
14 An Interventional Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients Withdrawn NCT03619187 Phase 3 Ivabradine
15 Propranolol in Severely Burned Children Active, not recruiting NCT01957449 Phase 2, Phase 3 Propranolol;Placebo
16 Dietary Intervention of Stress-Induced Neurovegetative Disorders With a Specific Amino Acid Composition (asn01) Completed NCT01425983 Phase 3
17 Protective Effects of Propranolol in Adults Recruiting NCT01902810 Phase 2, Phase 3 Propranolol;Placebo
18 Fenofibrate and Propranolol in Burn Patients Recruiting NCT02452255 Phase 2, Phase 3 Fenofibrate;Placebo;Propranolol
19 Bisoprolol in DMD Early Cardiomyopathy Recruiting NCT03779646 Phase 2, Phase 3 Bisoprolol Fumarate
20 Effect of Transcranial Direct Current Stimulation Associated With Aerobic Exercise Training for Patients With Fibromyalgia Completed NCT02358902 Phase 2, Phase 3
21 Stress Free UC Merced: The Effect of 8 Weeks of Mindfulness App Headspace on Stress in a Sample of University Employees Not yet recruiting NCT03652168 Phase 3
22 A Home-based Physical Activity Intervention in Breast Cancer Survivors Completed NCT02408107 Phase 3
23 Physical Fitness Training in Subacute Stroke (PHYS-Stroke) Completed NCT01953549 Phase 3
24 The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation Recruiting NCT03018041 Phase 3 Omacor;Placebo Oral Capsule
25 CHANGE -it is About Life Completed NCT01585493 Phase 3
26 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Active, not recruiting NCT03038594 Phase 2, Phase 3 Somatropin;0.09% Saline Solution
27 Efficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101) Completed NCT00163293 Phase 3 Ciclesonide;Placebo
28 IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study). Recruiting NCT03718273 Phase 3 Ivabradine;Digoxin
29 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis Recruiting NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules
30 Environmental Strategies & Behavior Change to Reduce Overeating in Obese Children Unknown status NCT01221220 Phase 2
31 Clinic, Family & Community Collaboration to Treat Overweight and Obese Children (Stanford GOALS) Unknown status NCT01642836 Phase 2
32 Efficacy and Safety of Mycophenolate Mofetil in subjectswithSjogren's Syndrome Unknown status NCT02691949 Phase 2 Mycophenolate mofetil
33 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
34 Heart Rate Variability in Response to Metformin Challenge Completed NCT02500628 Phase 2 Metformin
35 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity of Hemiplegics Completed NCT01569386 Phase 2
36 Sympatholysis in Chronic Kidney Disease Recruiting NCT02411773 Phase 2 Sodium Bicarbonate;Placebo
37 Promoting Wellbeing for Women With Depression: A Pragmatic Randomised Controlled Trial (RCT) of an Exercise Programme Completed NCT00546221 Phase 2
38 Sports to Prevent Obesity: Feasibility and Pilot RCT Completed NCT00186173 Phase 1, Phase 2
39 Central Meditation and Imagery Therapy for Augmentation of Borderline Personality Disorder Treatment Completed NCT02125942 Phase 1, Phase 2
40 Safety Study Using GSK573719 And Tiotropium In Patients With Chronic Obstructive Pulmonary Disease Completed NCT00515502 Phase 2 GSK573719;Tiotropium
41 Obesity Prevention for Pre-Adolescents Completed NCT00185978 Phase 2
42 Study to Promote Physical Activity Among Overweight Persons Completed NCT00313040 Phase 1, Phase 2
43 Effect of Exercise on Renal Function in Predialysis Completed NCT02155036 Phase 1, Phase 2
44 Beta Blocker Therapy in Mild to Moderate Asthmatics Completed NCT01544634 Phase 2 Propranolol;Placebo;Qvar 50;Qvar 100
45 Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension Recruiting NCT03617458 Phase 2 Metformin;Placebo
46 Study of the Clinical Activity, Safety, and Tolerability of SRT2104 in Subjects With Moderate to Severe Plaque-Type Psoriasis Completed NCT01154101 Phase 2 Placebo;SRT2104
47 Neurovascular Transduction During Exercise in Chronic Kidney Disease Recruiting NCT02947750 Phase 2 6R-BH4
48 Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam Completed NCT01940250 Phase 2 Magnesium Sulphate;Sterile water
49 South Asian Women & Yoga Education Study Unknown status NCT01667835 Phase 1
50 Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development Completed NCT01395342 Phase 1

Search NIH Clinical Center for Resting Heart Rate, Variation in

Genetic Tests for Resting Heart Rate, Variation in

Genetic tests related to Resting Heart Rate, Variation in:

# Genetic test Affiliating Genes
1 Resting Heart Rate 29 ADRB1

Anatomical Context for Resting Heart Rate, Variation in

MalaCards organs/tissues related to Resting Heart Rate, Variation in:

41
Heart, Testes, Kidney, Endothelial, Lung, Brain, Bone

Publications for Resting Heart Rate, Variation in

Articles related to Resting Heart Rate, Variation in:

(show top 50) (show all 457)
# Title Authors Year
1
The link between elevated long-term resting heart rate and SBP variability for all-cause mortality. ( 30005029 )
2019
2
The age-dependent relationship between resting heart rate variability and functional brain connectivity. ( 30312808 )
2019
3
Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. ( 29499053 )
2018
4
Relation of Elevated Resting Heart Rate in Mid-Life to Cognitive Decline Over 20 Years (from the Atherosclerosis Risk in Communities [ARIC] Study). ( 30424869 )
2018
5
Resting heart rate and the incidence and progression of valvular calcium: The Multi-Ethnic Study of Atherosclerosis (MESA). ( 29677630 )
2018
6
Clinical Feasibility of Monitoring Resting Heart Rate Using a Wearable Activity Tracker in Patients With Thyrotoxicosis: Prospective Longitudinal Observational Study. ( 30006328 )
2018
7
Associations of Insomnia Symptoms With Blood Pressure and Resting Heart Rate: The HUNT Study in Norway. ( 27726451 )
2018
8
Association between resting heart rate just before starting the first dialysis session and mortality: A multicentre prospective cohort study. ( 28332737 )
2018
9
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. ( 28637897 )
2018
10
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. ( 28659304 )
2018
11
Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance. ( 28856601 )
2018
12
Endogenous Pain Modulation: Association with Resting Heart Rate Variability and Negative Affectivity. ( 29016885 )
2018
13
Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart. ( 29098378 )
2018
14
Agreement analysis of oscillometric devices in the measure of resting heart rate in breast cancer survivors. ( 29135491 )
2018
15
Resting heart rate and the risk of hypertension and heart failure: a dose-response meta-analysis of prospective studies. ( 29176508 )
2018
16
Associations of the serum long-chain n-3 PUFA and hair mercury with resting heart rate, peak heart rate during exercise and heart rate recovery after exercise in middle-aged men. ( 29208059 )
2018
17
Association of Resting Heart Rate With Arterial Stiffness and Low-Grade Inflammation in Women With Systemic Lupus Erythematosus. ( 29232972 )
2018
18
Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality. ( 29269380 )
2018
19
Resting heart rate: A physiological predicator of lie detection ability. ( 29305871 )
2018
20
Low resting heart rate, sensation seeking and the course of antisocial behaviour across adolescence and young adulthood. ( 29310737 )
2018
21
Association of Resting Heart Rate and Temporal Changes in Heart Rate With Outcomes in Participants of the Atherosclerosis Risk in Communities Study. ( 29365021 )
2018
22
Knowledge of resting heart rate mediates the relationship between intelligence and the heartbeat counting task. ( 29378285 )
2018
23
Resting heart rate: what is normal? ( 29382691 )
2018
24
Resting heart rate variability is associated with ex-Gaussian metrics of intra-individual reaction time variability. ( 29408149 )
2018
25
Association of Early-Life Factors With Life-Course Trajectories of Resting Heart Rate: More Than 6 Decades of Follow-up. ( 29435577 )
2018
26
Does resting heart rate measured by the physician reflect the patient's true resting heart rate? White-coat heart rate. ( 29455795 )
2018
27
Sensitivity to psychosocial chronic stressors and adolescents' externalizing problems: Combined moderator effects of resting heart rate and parental psychiatric history. ( 29471016 )
2018
28
Resting Heart Rate Variability and the Effects of Biofeedback Intervention in Women with Low-Risk Pregnancy and Prenatal Childbirth Fear. ( 29476282 )
2018
29
Interaction of systolic blood pressure and resting heart rate with clinical outcomes in takotsubo syndrome: insights from the International Takotsubo Registry. ( 29517122 )
2018
30
Effects of resting heart rate on blood pressure and hypertension in Chinese children: findings from blood pressure surveillance program. ( 29553835 )
2018
31
Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study. ( 29557206 )
2018
32
Negative Affectivity, Depression, and Resting Heart Rate Variability (HRV) as Possible Moderators of Endogenous Pain Modulation in Functional Somatic Syndromes. ( 29559942 )
2018
33
Resting Heart Rate Is Not Associated with Cognitive Function. ( 29566380 )
2018
34
Relation of Resting Heart Rate to Incident Atrial Fibrillation (From ARIC [Atherosclerosis Risk in Communities] Study). ( 29576236 )
2018
35
Resting heart rate in late adolescence and long term risk of cardiovascular disease in Swedish men. ( 29579585 )
2018
36
Big data analysis from Sweden confirms that resting heart rate in late adolescence is significantly associated with incident heart failure and all-cause mortality. ( 29579605 )
2018
37
Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium. ( 29656781 )
2018
38
Association between Elevated Resting Heart Rate and Metabolic Syndrome in a Community-Based Population. ( 29664066 )
2018
39
Usefulness of a Low Resting Heart Rate to Predict Recurrence of Atrial Fibrillation After Catheter Ablation in People ≥65 Years of Age. ( 29685573 )
2018
40
Adding ivabradine to beta-blockers in chronic heart failure: Do not rest without lowering the resting heart rate sufficiently. ( 29716694 )
2018
41
Independent and combined effects of resting heart rate and pulse pressure with metabolic syndrome in Chinese rural population: The Henan Rural Cohort study. ( 29885318 )
2018
42
Resting Heart Rate Variability (HRV) in Adolescents and Young Adults from a Genetically-Informed Perspective. ( 29995284 )
2018
43
Resting heart rate variability in young women is a predictor of EEG reactions to linguistic ambiguity in sentences. ( 30006295 )
2018
44
Effects of olanzapine on resting heart rate in Japanese patients with schizophrenia. ( 30016331 )
2018
45
Increased Resting Heart Rate on Electrocardiogram Relative to In-office Pulse Rate Indicates Cardiac Overload: The J-HOP Study. ( 30020419 )
2018
46
Relationship between resting heart rate and metabolic risk factors in breast cancer patients. ( 30030991 )
2018
47
Association between Resting Heart Rate and Health-Related Physical Fitness in Brazilian Adolescents. ( 30050928 )
2018
48
Resting Heart Rate "Kinetics": Paradox or Means to Understand the Link Between Hypertension and Heart Failure? ( 30184080 )
2018
49
Association between resting heart rate and hypertension in Chinese with different waist-to-height ratio: a population-based cross-sectional study. ( 30268408 )
2018
50
Resting Heart Rate and Chronotropic Response to Exercise: Prognostic Implications in Heart Failure Across the Left Ventricular Ejection Fraction Spectrum. ( 30300684 )
2018

Variations for Resting Heart Rate, Variation in

ClinVar genetic disease variations for Resting Heart Rate, Variation in:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ADRB1 NM_000684.2(ADRB1): c.145A> G (p.Ser49Gly) single nucleotide variant Likely benign rs1801252 GRCh37 Chromosome 10, 115804036: 115804036
2 ADRB1 NM_000684.2(ADRB1): c.145A> G (p.Ser49Gly) single nucleotide variant Likely benign rs1801252 GRCh38 Chromosome 10, 114044277: 114044277

Expression for Resting Heart Rate, Variation in

Search GEO for disease gene expression data for Resting Heart Rate, Variation in.

Pathways for Resting Heart Rate, Variation in

Pathways related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 ADRA2B ADRB1 ADRB2
2
Show member pathways
12.25 ADRB1 ADRB2 TTF2
3
Show member pathways
12.18 ADRA2B ADRB1 ADRB2
4
Show member pathways
11.84 ADRB1 ADRB2
5
Show member pathways
11.8 ADRB1 ADRB2
6
Show member pathways
11.73 ADRB1 ADRB2
7 11.66 ADRB1 ADRB2
8 11.58 ADRB1 ADRB2
9 11.25 ADRB1 ADRB2
10
Show member pathways
11.19 ADRA2B ADRB1 ADRB2
11 11.07 ADRB1 ADRB2
12 10.99 ADRB1 ADRB2
13 10.71 ADRA2B ADRB1 ADRB2
14 10.16 ADRA2B ADRB1 ADRB2

GO Terms for Resting Heart Rate, Variation in

Biological processes related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.54 ADRA2B ADRB2
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.52 ADRB1 ADRB2
3 positive regulation of cold-induced thermogenesis GO:0120162 9.51 ADRB1 ADRB2
4 response to cold GO:0009409 9.49 ADRB1 ADRB2
5 activation of adenylate cyclase activity GO:0007190 9.48 ADRB1 ADRB2
6 brown fat cell differentiation GO:0050873 9.46 ADRB1 ADRB2
7 regulation of smooth muscle contraction GO:0006940 9.43 ADRA2B ADRB2
8 negative regulation of multicellular organism growth GO:0040015 9.4 ADRB1 ADRB2
9 adrenergic receptor signaling pathway GO:0071875 9.37 ADRA2B ADRB2
10 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.33 ADRA2B ADRB1 ADRB2
11 diet induced thermogenesis GO:0002024 9.32 ADRB1 ADRB2
12 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.26 ADRB1 ADRB2
13 heat generation GO:0031649 8.96 ADRB1 ADRB2
14 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.8 ADRA2B ADRB1 ADRB2

Molecular functions related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.43 ADRA2B ADRB1 ADRB2
2 norepinephrine binding GO:0051380 9.16 ADRB1 ADRB2
3 adrenergic receptor activity GO:0004935 9.13 ADRA2B ADRB1 ADRB2
4 epinephrine binding GO:0051379 8.8 ADRA2B ADRB1 ADRB2

Sources for Resting Heart Rate, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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