RHR
MCID: RST023
MIFTS: 41

Resting Heart Rate, Variation in (RHR)

Categories: Genetic diseases

Aliases & Classifications for Resting Heart Rate, Variation in

MalaCards integrated aliases for Resting Heart Rate, Variation in:

Name: Resting Heart Rate, Variation in 56
Resting Heart Rate 56 29 54 6 39 17
Rhr 56

Classifications:



External Ids:

OMIM 56 607276

Summaries for Resting Heart Rate, Variation in

MalaCards based summary : Resting Heart Rate, Variation in, also known as resting heart rate, is related to congestive heart failure and pain agnosia. An important gene associated with Resting Heart Rate, Variation in is ADRB1 (Adrenoceptor Beta 1), and among its related pathways/superpathways are NFAT and Cardiac Hypertrophy and cGMP-PKG signaling pathway. The drugs Metformin and Bisoprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and breast.

More information from OMIM: 607276

Related Diseases for Resting Heart Rate, Variation in

Diseases related to Resting Heart Rate, Variation in via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 congestive heart failure 29.9 ADRB2 ADRB1
2 pain agnosia 28.9 ADRB2 ADRB1 ADRA2B
3 body mass index quantitative trait locus 11 28.3 LEPQTL1 ADRB2 ADRB1
4 myocardial infarction 28.3 ADRB2 ADRB1 ADRA2B
5 hyperlipoproteinemia, type iii 10.4
6 lipoprotein quantitative trait locus 10.4
7 coronary heart disease 1 10.4
8 arteries, anomalies of 10.4
9 heart disease 10.4
10 atherosclerosis susceptibility 10.3
11 atrial fibrillation 10.3
12 vascular disease 10.3
13 lipid metabolism disorder 10.3
14 renovascular hypertension 10.3
15 cardiac conduction defect 10.2
16 autonomic dysfunction 10.2
17 angina pectoris 10.2
18 autonomic neuropathy 10.2
19 ischemia 10.2
20 atrial standstill 1 10.1
21 body mass index quantitative trait locus 1 10.1
22 hypercholesterolemia, familial, 1 10.1
23 hypertension, essential 10.1
24 systemic lupus erythematosus 10.1
25 anxiety 10.1
26 dilated cardiomyopathy 10.1
27 transient cerebral ischemia 10.1
28 neuropathy 10.1
29 diabetes mellitus 10.1
30 hutterite cerebroosteonephrodysplasia syndrome 10.0
31 ocular motor apraxia 10.0
32 pulmonary disease, chronic obstructive 10.0
33 peripheral vascular disease 10.0
34 sick sinus syndrome 10.0
35 cardiovascular cancer 10.0
36 impotence 10.0
37 rectum cancer 10.0
38 post-traumatic stress disorder 10.0
39 panic disorder 10.0
40 acute stress disorder 10.0
41 cerebrovascular disease 10.0
42 hyperthyroidism 10.0
43 brain injury 10.0
44 traumatic brain injury 10.0
45 aortic aneurysm, familial abdominal, 1 9.8
46 colorectal cancer 9.8
47 cardiac arrhythmia 9.8
48 obsessive-compulsive disorder 9.8
49 pulmonary hypertension, primary, 1 9.8
50 tetralogy of fallot 9.8

Graphical network of the top 20 diseases related to Resting Heart Rate, Variation in:



Diseases related to Resting Heart Rate, Variation in

Symptoms & Phenotypes for Resting Heart Rate, Variation in

Clinical features from OMIM:

607276

Drugs & Therapeutics for Resting Heart Rate, Variation in

Drugs for Resting Heart Rate, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Bisoprolol Approved Phase 4 66722-44-9 2405
3
Interferon beta-1b Approved Phase 4 145155-23-3
4
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
5
Gliclazide Approved Phase 4 21187-98-4 3475
6
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
7
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
8 Hypoglycemic Agents Phase 4
9 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
10 Sodium-Glucose Transporter 2 Inhibitors Phase 4
11 Interferon-beta Phase 4
12 (T,G)-A-L Phase 4
13 Fingolimod Hydrochloride Phase 4
14 interferons Phase 4
15 Immunosuppressive Agents Phase 4
16
Glatiramer Acetate Phase 4 147245-92-9 3081884
17 Immunologic Factors Phase 4
18 Anti-Bacterial Agents Phase 4
19 Anti-Infective Agents Phase 4
20 Norgestimate, ethinyl estradiol drug combination Phase 4
21
Glucagon Approved Phase 3 16941-32-5
22
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
23
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
24
Liraglutide Approved Phase 3 204656-20-2 44147092
25
Ephedrine Approved Phase 2, Phase 3 299-42-3 9294
26
Pseudoephedrine Approved Phase 2, Phase 3 90-82-4 7028
27
tannic acid Approved Phase 2, Phase 3 1401-55-4
28
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
29
Phenylephrine Approved Phase 2, Phase 3 59-42-7 6041
30
Norepinephrine Approved Phase 2, Phase 3 51-41-2 439260
31
Oxymetazoline Approved, Investigational Phase 2, Phase 3 1491-59-4 4636
32
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
33
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
34
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
35
Asparagine Approved, Investigational, Nutraceutical Phase 3 70-47-3 6267
36
2,4-thiazolidinedione Investigational Phase 3 2295-31-0
37 Adrenergic beta-Antagonists Phase 3
38 Adrenergic beta-1 Receptor Antagonists Phase 3
39 Antihypertensive Agents Phase 3
40 Adrenergic Antagonists Phase 3
41 Sympatholytics Phase 3
42 Glucagon-Like Peptide 1 Phase 3
43 Pharmaceutical Solutions Phase 3
44 Hormones Phase 3
45 Progestins Phase 3
46 Contraceptive Agents Phase 3
47 Contraceptive Agents, Male Phase 3
48 Contraceptives, Oral Phase 3
49 Antineoplastic Agents, Hormonal Phase 3
50 Hormone Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 173)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Ivabradine in Hemodialysed Patients With Increased Heart Rate Unknown status NCT01364077 Phase 4 Ivabradine;Placebo
2 Randomised, Double-blind, Placebo-controlled Trial of IVabradine in Patients With Acute Coronary Syndrome: Effects of the If Current Inhibitor Ivabradine or rEduction of Inflammation maRkers in Patients With Acute Coronary Syndrome Unknown status NCT00815100 Phase 4 Ivabradine;Placebo
3 Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Patients With Essential Hypertension Completed NCT01251146 Phase 4 Bisoprolol;Atenolol
4 A 12-month, Prospective, Randomized, Active-controlled, Open-label Study to Evaluate the Patient Retention of Fingolimod vs. Approved First-line Disease Modifying Therapies in Adults With Relapsing Remitting Multiple Sclerosis (PREFERMS) Completed NCT01623596 Phase 4 Fingolimod;Disease Modifying therapy
5 A Randomized, Double-blind, Comparator-controlled Trial to Assess the Effect of 12-week Treatment With Dapagliflozin Versus Gliclazide on Renal Physiology and Biomarkers in Metformin-treated Patients With Type 2 Diabetes Mellitus Completed NCT02682563 Phase 4 Dapagliflozin 10mg QD;Gliclazide 30mg QD
6 The Effect of Ivabradine Treatment on Exercise Capacity in Patients With Cardiac Allograft Vasculopathy After Heart Transplantation Recruiting NCT03405831 Phase 4 Ivabradine;Placebo
7 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
8 Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
9 Genetics of QT Response to Moxifloxacin Enrolling by invitation NCT01936480 Phase 4 Moxifloxacin 400mg once time;Placebo
10 Ivabradine in Stage D Heart Failure Patients on Chronic Inotropes: A Pilot Study Not yet recruiting NCT03631654 Phase 4 Ivabradine;Placebos
11 Prospective, Randomized, Single-Center Study to Compare Clinical Outcomes Between Cryopreserved and Lyopreserved Stravix as an Adjunct to NPWT in the Treatment of Complex Wounds Not yet recruiting NCT04405765 Phase 4
12 Randomized Clinical Trial to Compare Restrata and Negative Pressure Wound Therapy (NPWT) to Heal Complex Diabetic Foot Wounds Not yet recruiting NCT04405050 Phase 4
13 Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC) Unknown status NCT02584439 Phase 3 ivabradine;lactose capsule (placebo)
14 Dietary Intervention of Stress-Induced Neurovegetative Disorders in Men and Women With a Specific Amino Acid Composition With Micronutrients Completed NCT01425983 Phase 3
15 A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of MLD10 in the Prevention of Migraine Headache in Adults Completed NCT02322333 Phase 2, Phase 3 MLD10;Placebo
16 Effect of Transcranial Direct Current Stimulation Associated With Aerobic Exercise Training for Patients With Fibromyalgia Completed NCT02358902 Phase 2, Phase 3
17 Exercise to Improve Sleep in Heart Failure Completed NCT00194701 Phase 3
18 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed NCT00000466 Phase 3 estrogens, conjugated;medroxyprogesterone;progesterone;estrogen replacement therapy
19 Impact of Liraglutide on Cardiac Function and Structure in Young Adults With Type 2 Diabetes: an Open-label, Randomised Active-comparator Trial Completed NCT02043054 Phase 3 Liraglutide;Sitagliptin
20 A Randomized Double-blind Placebo Force-titration Controlled Study With Bisoprolol in Patients With Chronic Heart Failure Secondary to Chagas´ Cardiomyopathy. Completed NCT00323973 Phase 3 Bisoprolol
21 The Long-term Effect of Marine n-3 Polyunsaturated Fatty Acid Supplementation on Glomerular Filtration Rate and Development of Fibrosis in the Renal Allograft: a Randomized Double Blind Placebo Controlled Intervention Study Recruiting NCT03018041 Phase 3 Omacor;Placebo Oral Capsule
22 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
23 A Phase 3, Open-label, Multicenter Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients With Elevated Resting Heart Rate Withdrawn NCT03619187 Phase 3 Ivabradine
24 Dapagliflozin During Exercise for the Prevention of Hypoglycaemia in Type 1 Diabetes Unknown status NCT03537131 Phase 2 Dapagliflozin 10 MG Oral Tablet
25 Heart Rate Variability in Response to Metformin Challenge Completed NCT02500628 Phase 2 Metformin
26 Low-dose Glibenclamide in Type 2 Diabetes Mellitus - Part A Completed NCT02830048 Phase 2 Glibenclamide
27 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
28 Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults Recruiting NCT03821623 Phase 2 Nicotinamide riboside
29 A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms Active, not recruiting NCT03075826 Phase 2 SGI-110
30 Functional Sympatholysis and Exercise Intolerance in Chronic Kidney Disease Suspended NCT02411773 Phase 2 Sodium Bicarbonate;Placebo
31 Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease Suspended NCT02947750 Phase 2 6R-BH4
32 Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development Completed NCT01395342 Phase 1
33 Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus (Exercise SLE Pilot) Recruiting NCT03186794 Phase 1
34 The Link Between the Clinical Resting Heart Rate and Sympathetic Overactivation Unknown status NCT02315313
35 A Single Centre, Retrospective Cohort Study on Post Analysis on the Link Between the Clinical Heart Rate and Outcomes During PCI Unknown status NCT02351674
36 Helbred2016: Monitorering af Kroniske Sygdomme og Risikofaktorer i Befolkningen Unknown status NCT02720809
37 INCreasing Exercise adhereNce After percuTaneous Coronary InterVEntion With the Fitbit Charge HR Device: the INCENTIVE Trial Unknown status NCT02788929
38 Study of Cardiovascular Responses to Static and Dynamic Exercise in Isolated Systolic Hypertension Unknown status NCT02270216
39 Prospective Interventional Study of the Impact of 3-step Diet With Complimentary Exercise Program Unknown status NCT01991002
40 Randomized Trial of Cardiovascular Response to Two Manual Techniques Non-thrust Joint Manipulation of the Cervical Spine in Patients With Non-traumatic Mechanical Neck Pain. Unknown status NCT02198677
41 Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly Unknown status NCT02791139
42 The Manifestation of Surface EMG of Swallowing Muscles in Stroke Patients With Respiratory Muscle Training. A Prospective Study. Unknown status NCT03767998
43 Effects of 12 Weeks of Omega-3 Fatty Acid Supplementation on Metabolic and Physical Health Parameters in Older Adults Unknown status NCT01734538
44 Increasing Physical Activity in Stroke Survivors Using STARFISH, an Interactive Mobile Phone Application: a Feasibility Study Unknown status NCT01792349
45 The Effects of a 12-week Cardiovascular Rehabilitation Exercise Program on Inflammatory Markers and Traditional Coronary Artery Disease Risk Factors in Patients With Rheumatoid Arthritis Unknown status NCT01534871
46 Effect of Rebound Exercises and Circuit Training on Musculoskeletal Pain, Selected Biochemical and Psychosocial Parameters Among Individuals With Type 2 Diabetics Unknown status NCT03200795
47 The Addition of Cardiac Computed Tomography to Exercise Treadmill Testing in the Evaluation of Angina Unknown status NCT00491218
48 Observational Non-interventional Study - Epidemiological Survey "AchievemenT of Goal Resting HEart Rate on Beta-blockers in Patients With Stable angiNA and Hypertension in Routine Practice" Completed NCT01321242
49 Determinants of Chronotropic Incompetence in Patients With Heart Failure and a Preserved Ejection Fraction (HFpEF) Completed NCT02524145 Dexmedetomidine;Glycopyrrolate;Isoproterenol
50 RAte Control Efficacy in Permanent Atrial Fibrillation, a Comparison Between Lenient Versus Strict Rate Control in Patients With and Without Heart Failure. Completed NCT00392613

Search NIH Clinical Center for Resting Heart Rate, Variation in

Genetic Tests for Resting Heart Rate, Variation in

Genetic tests related to Resting Heart Rate, Variation in:

# Genetic test Affiliating Genes
1 Resting Heart Rate 29 ADRB1

Anatomical Context for Resting Heart Rate, Variation in

MalaCards organs/tissues related to Resting Heart Rate, Variation in:

40
Heart, Testes, Breast, Endothelial, Lung, Thyroid, Kidney

Publications for Resting Heart Rate, Variation in

Articles related to Resting Heart Rate, Variation in:

(show top 50) (show all 3710)
# Title Authors PMID Year
1
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. 6 61 54 56
11854867 2002
2
Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. 61 56
12189495 2002
3
The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study) 61 56
10637085 2000
4
Heart rate and cardiovascular mortality: the Framingham Study. 61 56
3591616 1987
5
Several common variants modulate heart rate, PR interval and QRS duration. 56
20062063 2010
6
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. 56
20031603 2009
7
Heritability of heart rate variability: the Framingham Heart Study. 56
10226089 1999
8
Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. 61 54
16907703 2006
9
Association between ghrelin and cardiovascular indexes in healthy obese and lean men. 54 61
14678289 2004
10
Principal components of fitness: relationship to physical activity and lifestyle. 61 54
8081323 1994
11
Associations between the serum levels of selected bone turnover markers and biological traits in nursing home women aged 80+ without inflammation. A pilot study. 61
32428562 2020
12
Cardiac autonomic dysfunction in survivors of childhood acute lymphoblastic leukemia: The St. Jude Lifetime Cohort Study. 61
32383821 2020
13
Prenatal Exercise and Cardiorespiratory Health and Fitness: A Meta-analysis. 61
31977635 2020
14
Impaired glucose control is associated with multiple cardiovascular impairments. 61
32298517 2020
15
Nonexercise Equations for Determining Change in Cardiorespiratory Fitness. 61
31977632 2020
16
Does intensive multidisciplinary intervention for adults who elect bariatric surgery improve post-operative weight loss, co-morbidities, and quality of life? A systematic review and meta-analysis. 61
32196906 2020
17
Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls. 61
32497584 2020
18
An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial. 61
32545396 2020
19
Participation in Non-professional Sports and Cardiovascular Outcomes Among Adolescents: ABCD Growth Study. 61
32323117 2020
20
Cardiovascular adaptations after 10 months of daily 12-min bouts of intense school-based physical training for 8-10-year-old children. 61
32497586 2020
21
Quantitative 3D myocardial perfusion with an efficient arterial input function. 61
31670858 2020
22
[Bivariate heritability estimation of resting heart rate and common chronic disease based on extended pedigrees]. 61
32541974 2020
23
Impact of obesity on walking capacity and cardiovascular parameters in patients with peripheral artery disease: A cross-sectional study. 61
32534655 2020
24
Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy. 61
32347018 2020
25
Cardiac-Autonomic Responses to In-Season Training Among Division-1 College Football Players. 61
29461413 2020
26
Football can tackle type 2 diabetes: a systematic review of the health effects of recreational football practice in individuals with prediabetes and type 2 diabetes. 61
32567951 2020
27
Time-updated resting heart rate predicts mortality in patients with COPD. 61
31734762 2020
28
Low Resting Heart Rate and Stalking Perpetration. 61
29294708 2020
29
Reactive stress-coping styles show more variable reproductive expenditure and fitness outcomes. 61
32533041 2020
30
Media Exposure to Terrorism and Perception of Immigrants as a Threat: The Role of Emotional Intelligence and Psychophysiological Self-Regulation. 61
32542673 2020
31
Heart rate as a predictor of cardiovascular risk. 61
32512980 2020
32
External validity of a model to predict postoperative atrial fibrillation after thoracic surgery. 61
31845993 2020
33
A nurse-led intervention to promote physical activity in sedentary older adults with cardiovascular risk factors: a randomized clinical trial (STEP-IT-UP study). 61
32363918 2020
34
Weekly Osteopathic Manipulative Treatment to Improve Measures of Sympathetic Tone in Women With Polycystic Ovary Syndrome: A Randomized, Controlled Pilot Study. 61
32337566 2020
35
Baseline intrinsic heart rate and response to ivabradine treatment in patients with inappropriate sinus tachycardia. 61
31595620 2020
36
Psychobiological markers of allostatic load in depressed and nondepressed mothers and their adolescent offspring. 61
32438475 2020
37
Modelling performance during repetitive precision tasks using wearable sensors: a data-driven approach. 61
32321375 2020
38
Feasible assessment of recovery and cardiovascular health: accuracy of nocturnal HR and HRV assessed via ring PPG in comparison to medical grade ECG. 61
32217820 2020
39
Geometry of the Poincaré plot can segregate the two arms of autonomic nervous system - A hypothesis. 61
32014816 2020
40
Higher doses of a green tea-based supplement increase post-exercise blood flow following an acute resistance exercise bout in recreationally resistance-trained college-aged men. 61
32460790 2020
41
The link between resting heart rate variability and affective flexibility. 61
32462431 2020
42
Heart Rate, Brain Imaging Biomarkers and Cognitive Impairment in Older (≥63 years) Women. 61
32576368 2020
43
Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study. 61
32433047 2020
44
Determinants of Exercise Capacity Assessed With the Modified Shuttle Test in Individuals With Cystic Fibrosis. 61
32047118 2020
45
Resting Heart Rate and Diastolic Blood Pressure in AR: Still a Matter of Debate. 61
32354392 2020
46
[A cohort study on the association between resting heart rate and the risk of new-onset heart failure]. 61
32450659 2020
47
Clustering of risk factors and the risk of new-onset hypertension defined by the 2017 ACC/AHA Hypertension Guideline. 61
31431682 2020
48
Polymorphism of the Beta-1 Gly389Arg receptor in patients with dual atrioventricular nodal physiology. 61
32224090 2020
49
Estimated cardiorespiratory fitness in childhood and cardiometabolic health in adulthood: 1970 British Cohort Study. 61
32037646 2020
50
Ethnic Differences in Resting Total Peripheral Resistance: A Systematic Review and Meta-Analysis. 61
32412944 2020

Variations for Resting Heart Rate, Variation in

ClinVar genetic disease variations for Resting Heart Rate, Variation in:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ADRB1 NM_000684.3(ADRB1):c.145A>G (p.Ser49Gly)SNV Likely benign 17747 rs1801252 10:115804036-115804036 10:114044277-114044277

Expression for Resting Heart Rate, Variation in

Search GEO for disease gene expression data for Resting Heart Rate, Variation in.

Pathways for Resting Heart Rate, Variation in

Pathways related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 ADRB2 ADRB1 ADRA2B
2
Show member pathways
11.83 ADRB2 ADRB1 ADRA2B
3
Show member pathways
11.7 ADRB2 ADRB1
4 11.62 ADRB2 ADRB1
5 11.54 ADRB2 ADRB1
6 11.21 ADRB2 ADRB1
7
Show member pathways
11.17 ADRB2 ADRB1 ADRA2B
8 11.07 ADRB2 ADRB1
9 11 ADRB2 ADRB1
10 10.16 ADRB2 ADRB1 ADRA2B

GO Terms for Resting Heart Rate, Variation in

Biological processes related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.63 ADRB2 ADRB1 ADRA2B
2 positive regulation of MAPK cascade GO:0043410 9.55 ADRB2 ADRA2B
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 ADRB2 ADRB1
4 positive regulation of cold-induced thermogenesis GO:0120162 9.52 ADRB2 ADRB1
5 activation of adenylate cyclase activity GO:0007190 9.51 ADRB2 ADRB1
6 response to cold GO:0009409 9.49 ADRB2 ADRB1
7 brown fat cell differentiation GO:0050873 9.48 ADRB2 ADRB1
8 regulation of smooth muscle contraction GO:0006940 9.43 ADRB2 ADRA2B
9 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.43 ADRB2 ADRB1 ADRA2B
10 adrenergic receptor signaling pathway GO:0071875 9.4 ADRB2 ADRA2B
11 negative regulation of multicellular organism growth GO:0040015 9.37 ADRB2 ADRB1
12 diet induced thermogenesis GO:0002024 9.32 ADRB2 ADRB1
13 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.16 ADRB2 ADRB1
14 heat generation GO:0031649 8.96 ADRB2 ADRB1
15 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.8 ADRB2 ADRB1 ADRA2B

Molecular functions related to Resting Heart Rate, Variation in according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.43 ADRB2 ADRB1 ADRA2B
2 norepinephrine binding GO:0051380 9.16 ADRB2 ADRB1
3 adrenergic receptor activity GO:0004935 9.13 ADRB2 ADRB1 ADRA2B
4 epinephrine binding GO:0051379 8.8 ADRB2 ADRB1 ADRA2B

Sources for Resting Heart Rate, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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