RLS3
MCID: RST014
MIFTS: 13

Restless Legs Syndrome 3 (RLS3)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Restless Legs Syndrome 3

MalaCards integrated aliases for Restless Legs Syndrome 3:

Name: Restless Legs Syndrome 3 57
Restless Legs Syndrome, Susceptibility to, 3 57 53 13
Rls3 57 53

Classifications:



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Summaries for Restless Legs Syndrome 3

OMIM : 57 Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). For additional information and a discussion of genetic heterogeneity of restless legs syndrome, see RLS1 (102300). (610438)

MalaCards based summary : Restless Legs Syndrome 3, also known as restless legs syndrome, susceptibility to, 3, is related to restless legs syndrome. An important gene associated with Restless Legs Syndrome 3 is RLS3 (Restless Legs Syndrome 3).

Related Diseases for Restless Legs Syndrome 3

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1 Restless Legs Syndrome 2
Restless Legs Syndrome 3 Restless Legs Syndrome 4
Restless Legs Syndrome 6 Restless Legs Syndrome 5
Restless Legs Syndrome 7 Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 12.2

Symptoms & Phenotypes for Restless Legs Syndrome 3

Clinical features from OMIM:

610438

Drugs & Therapeutics for Restless Legs Syndrome 3

Search Clinical Trials , NIH Clinical Center for Restless Legs Syndrome 3

Genetic Tests for Restless Legs Syndrome 3

Anatomical Context for Restless Legs Syndrome 3

Publications for Restless Legs Syndrome 3

Articles related to Restless Legs Syndrome 3:

(show all 11)
# Title Authors PMID Year
1
Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci? 38 8
18032746 2008
2
RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity. 38 8
16864828 2006
3
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 8
18660810 2008
4
No convincing evidence of linkage for restless legs syndrome on chromosome 9p. 8
15747259 2005
5
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. 8
15077200 2004
6
Autosomal dominant restless legs syndrome maps on chromosome 14q. 8
12764067 2003
7
RLS3, a protein with AAA+ domain localized in chloroplast, sustains leaf longevity in rice. 38
27357911 2016
8
Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome. 38
21264940 2011
9
Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. 38
17133505 2007
10
Genetic aspects of restless legs syndrome. 38
17068272 2006
11
Understanding the pathogenesis of the restless legs syndrome at the level of the dopamine receptor. Are we about to identify the neurochemical deficiency causing schizophrenia? 38
2710021 1989

Variations for Restless Legs Syndrome 3

Expression for Restless Legs Syndrome 3

Search GEO for disease gene expression data for Restless Legs Syndrome 3.

Pathways for Restless Legs Syndrome 3

GO Terms for Restless Legs Syndrome 3

Sources for Restless Legs Syndrome 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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