RLS3
MCID: RST014
MIFTS: 13

Restless Legs Syndrome 3 (RLS3)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Restless Legs Syndrome 3

MalaCards integrated aliases for Restless Legs Syndrome 3:

Name: Restless Legs Syndrome 3 56
Restless Legs Syndrome, Susceptibility to, 3 56 52 13
Rls3 56 52

Classifications:



External Ids:

OMIM 56 610438
OMIM Phenotypic Series 56 PS102300

Summaries for Restless Legs Syndrome 3

OMIM : 56 Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). For additional information and a discussion of genetic heterogeneity of restless legs syndrome, see RLS1 (102300). (610438)

MalaCards based summary : Restless Legs Syndrome 3, also known as restless legs syndrome, susceptibility to, 3, is related to restless legs syndrome. An important gene associated with Restless Legs Syndrome 3 is RLS3 (Restless Legs Syndrome 3).

Related Diseases for Restless Legs Syndrome 3

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1 Restless Legs Syndrome 2
Restless Legs Syndrome 3 Restless Legs Syndrome 4
Restless Legs Syndrome 6 Restless Legs Syndrome 5
Restless Legs Syndrome 7 Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1, show less)
# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 12.2

Symptoms & Phenotypes for Restless Legs Syndrome 3

Clinical features from OMIM:

610438

Drugs & Therapeutics for Restless Legs Syndrome 3

Search Clinical Trials , NIH Clinical Center for Restless Legs Syndrome 3

Genetic Tests for Restless Legs Syndrome 3

Anatomical Context for Restless Legs Syndrome 3

Publications for Restless Legs Syndrome 3

Articles related to Restless Legs Syndrome 3:

(showing 12, show less)
# Title Authors PMID Year
1
Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci? 56 61
18032746 2008
2
RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity. 56 61
16864828 2006
3
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 56
18660810 2008
4
No convincing evidence of linkage for restless legs syndrome on chromosome 9p. 56
15747259 2005
5
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. 56
15077200 2004
6
Autosomal dominant restless legs syndrome maps on chromosome 14q. 56
12764067 2003
7
Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. 61
32276028 2020
8
RLS3, a protein with AAA+ domain localized in chloroplast, sustains leaf longevity in rice. 61
27357911 2016
9
Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome. 61
21264940 2011
10
Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. 61
17133505 2007
11
Genetic aspects of restless legs syndrome. 61
17068272 2006
12
Understanding the pathogenesis of the restless legs syndrome at the level of the dopamine receptor. Are we about to identify the neurochemical deficiency causing schizophrenia? 61
2710021 1989

Variations for Restless Legs Syndrome 3

Expression for Restless Legs Syndrome 3

Search GEO for disease gene expression data for Restless Legs Syndrome 3.

Pathways for Restless Legs Syndrome 3

GO Terms for Restless Legs Syndrome 3

Sources for Restless Legs Syndrome 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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