RLS6
MCID: RST020
MIFTS: 21

Restless Legs Syndrome 6 (RLS6)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Name: Restless Legs Syndrome 6 57 72 13
Rls6 57 20 72
Restless Legs Syndrome, Susceptibility to, 6 57 20
Periodic Limb Movements in Sleep 57 20

Classifications:



External Ids:

OMIM® 57 611185
OMIM Phenotypic Series 57 PS102300
MeSH 44 D012148
MedGen 41 C1970020

Summaries for Restless Legs Syndrome 6

OMIM® : 57 Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Limb movements during sleep are more common in otherwise asymptomatic family members of patients with RLS compared to the general population (Stefansson et al., 2007). Thus, periodic limb movements during sleep may serve as an endophenotype for RLS. However, not all patients with RLS have limb movements during sleep, and the majority of individuals with limb movements during sleep do not have waking symptoms of RLS (Winkelman, 2007). For additional information and a discussion of genetic heterogeneity of RLS, see RLS1 (102300). (611185) (Updated 05-Apr-2021)

MalaCards based summary : Restless Legs Syndrome 6, also known as rls6, is related to restless legs syndrome and restless legs syndrome 7. An important gene associated with Restless Legs Syndrome 6 is RLS6 (Restless Legs Syndrome, Susceptibility To, 6). The drugs Dopamine and Iron have been mentioned in the context of this disorder.

UniProtKB/Swiss-Prot : 72 Restless legs syndrome 6: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

Related Diseases for Restless Legs Syndrome 6

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:



Diseases related to Restless Legs Syndrome 6

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM®:

611185 (Updated 05-Apr-2021)

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved 62-31-7, 51-61-6 681
2
Iron Approved 7439-89-6 23925 29936
3 Iron Supplement

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dopamine Transporter Density Profiles Assessed by Tc-TRODAT and SPECT in Patients With Periodic Limb Movements Completed NCT01365364
2 Impact of Iron Supplementation Treatment on Brain Iron Concentrations Among Children With ADHD & Restless Leg Syndrome Combined With Periodic Limb Movements in Sleep Not yet recruiting NCT04144790

Search NIH Clinical Center for Restless Legs Syndrome 6

Genetic Tests for Restless Legs Syndrome 6

Anatomical Context for Restless Legs Syndrome 6

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

(show all 14)
# Title Authors PMID Year
1
MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease. 57
21572129 2011
2
MEIS1 p.R272H in familial restless legs syndrome. 57
19620614 2009
3
Replication of restless legs syndrome loci in three European populations. 57
19279021 2009
4
A genetic risk factor for periodic limb movements in sleep. 57
18216367 2008
5
A genetic risk factor for periodic limb movements in sleep. 57
17634447 2007
6
Periodic limb movements in sleep--endophenotype for restless legs syndrome? 57
17634452 2007
7
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 57
17637780 2007
8
The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) Trial: A Protocol for a Randomized, Crossover, Placebo-Controlled Blinded Trial. 61
33294203 2020
9
The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare. 61
31879618 2019
10
A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders. 61
29896152 2018
11
Validation of the Kohnen Restless Legs Syndrome-Quality of Life instrument. 61
27810174 2016
12
Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease. 61
27318235 2016
13
Post Hoc Analysis of Data from Two Clinical Trials Evaluating the Minimal Clinically Important Change in International Restless Legs Syndrome Sum Score in Patients with Restless Legs Syndrome (Willis-Ekbom Disease). 61
26446245 2016
14
Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire. 61
24246378 2013

Variations for Restless Legs Syndrome 6

Expression for Restless Legs Syndrome 6

Search GEO for disease gene expression data for Restless Legs Syndrome 6.

Pathways for Restless Legs Syndrome 6

GO Terms for Restless Legs Syndrome 6

Sources for Restless Legs Syndrome 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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