Restless Legs Syndrome 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Name: Restless Legs Syndrome 6 ⁵⁷ ⁷⁵

Restless Legs Syndrome, Susceptibility to, 6 ⁵⁷ ⁵³ ¹³

Rls6 ⁵⁷ ⁵³ ⁷⁵

Periodic Limb Movements in Sleep ⁵⁷ ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 611185

MedGen ⁴² C1970020

MeSH ⁴⁴ D012148

Sources

Summaries for Restless Legs Syndrome 6

OMIM : ⁵⁷ Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Limb movements during sleep are more common in otherwise asymptomatic family members of patients with RLS compared to the general population (Stefansson et al., 2007). Thus, periodic limb movements during sleep may serve as an endophenotype for RLS. However, not all patients with RLS have limb movements during sleep, and the majority of individuals with limb movements during sleep do not have waking symptoms of RLS (Winkelman, 2007). For additional information and a discussion of genetic heterogeneity of RLS, see RLS1 (102300). (611185)

MalaCards based summary : Restless Legs Syndrome 6, also known as restless legs syndrome, susceptibility to, 6, is related to restless legs syndrome and periodic limb movement disorder. An important gene associated with Restless Legs Syndrome 6 is RLS6 (Restless Legs Syndrome, Susceptibility To, 6). The drugs Rotigotine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart.

UniProtKB/Swiss-Prot : ⁷⁵ Restless legs syndrome 6: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

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Related Diseases for Restless Legs Syndrome 6

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1	Restless Legs Syndrome 2
Restless Legs Syndrome 3	Restless Legs Syndrome 4
Restless Legs Syndrome 6	Restless Legs Syndrome 5
Restless Legs Syndrome 7	Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	restless legs syndrome	32.2	BTBD9 RLS6
2	periodic limb movement disorder	11.5
3	restless legs syndrome 7	11.1
4	attention deficit-hyperactivity disorder	10.0
5	williams-beuren syndrome	10.0
6	autism	10.0
7	congestive heart failure	10.0
8	dementia	10.0
9	sickle cell disease	10.0

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:

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Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM:

611185

Sources

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rotigotine

Approved

Phase 4,Phase 3

99755-59-6, 92206-54-7

57537

2

Dopamine

Approved

Phase 4,Phase 3

51-61-6, 62-31-7

681

Synonyms:

(3H)-Dopamine

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-dihydroxyphenyl)ethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

2-benzenediol

3,4 Dihydroxyphenethylamine

3,4-dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)catechol

4-(2-Aminoethyl)catechol

4-(2-aminoethyl)pyrocatechol

4-(2-aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

a-(3,4-Dihydroxyphenyl)-b-aminoethane

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

ASL 279

BIDD:ER0506

Biomol-NT_000001

BPBio1_001123

BSPBio_001932

C03758

CHEBI:18243

CHEMBL59

CID681

cMAP_000036

cMAP_000065

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

dopamine

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopamine hydrochloride

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydrochloride, dopamine

Hydroxytyramin

hydroxytyramine

Hydroxytyramine

IDI1_000780

intropin

Intropin

Intropin [*hydrochloride*]

IP 498

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L000232

L-DOPAMINE

LDP

Lopac0_000586

Lopac-H-8502

LS-159

Medopa (TN)

m-Hydroxytyramine hydrochloride

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

Spectrum_001012

SPECTRUM1505155

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

ST048774

STK301601

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

3

Pramipexole

Approved, Investigational

Phase 4

104632-26-0

119570 59868

Synonyms:

(-)-Pramipexole

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

(S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

104632-26-0

111GE001

2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

2-amino-4,5,6,7-tetrahydro-6-Propylaminobenzothiazole

2-amino-6-propylaminotetrahydrobenzothiazole

2-amino-6-Propylaminotetrahydrobenzothiazole

4,5,6,7-tetrahydro-N6-Propyl-2,6-benzothiazole-diamine

6,7-tetrahydro-N6-Propyl-2,6-benzothiazolediamine dihydrochloride monohydrate

AC1L3P1T

BIDD:GT0250

C10H17N3S

CHEBI:8356

CHEMBL301265

CID119570

CPD000449298

D05575

Dexpramipexole

DivK1c_006916

Furfuryl Acetate

HMS2051A21

HMS2090C15

KBio1_001860

KBio2_002340

KBio2_004908

KBio2_007476

KBioSS_002343

LS-40722

Mirapex

MLS000758250

MLS001423952

MolPort-003-849-957

NCGC00167441-01

Pramipexol

Pramipexol [Spanish]

Pramipexol dihydrobromide, (+-)-isomer

Pramipexol dihydrochloride, (S)-isomer

Pramipexol, (+-)-isomer

Pramipexol, (R)-isomer

pramipexole

Pramipexole

Pramipexole (USAN/INN)

Pramipexole [USAN:INN]

Pramipexole 2HCl Monohydrate

Pramipexole hydrochloride

Pramipexolum

Pramipexolum [Latin]

SAM001247006

SBB070477

Sifrole

SMR000449298

SND 919CL2X

SND-919

SND919CL2X

SND-919CL2X

SpecPlus_000820

Spectrum_001838

Spectrum5_001453

SUD919CL2Y

U-98528E

4

Dopamine Agents

Phase 4,Phase 3

5

Dopamine agonists

Phase 4,Phase 3

6

Neurotransmitter Agents

Phase 4,Phase 3

7

Antioxidants

Phase 4

8

Antiparkinson Agents

Phase 4

9

Protective Agents

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome	Completed	NCT01455012	Phase 4	Rotigotine;Placebo
2	Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS)	Completed	NCT00472199	Phase 4	Pramipexole;Placebo
3	DIalysis Symptom COntrol-Restless Legs Syndrome Trial	Not yet recruiting	NCT03806530	Phase 3	Gabapentin;Ropinirole;Placebo Gabapentin;Placebo Ropinirole
4	Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS)	Completed	NCT01569464	Phase 3	Rotigotine
5	Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS)	Completed	NCT00887289

Search NIH Clinical Center for Restless Legs Syndrome 6

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Genetic Tests for Restless Legs Syndrome 6

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Anatomical Context for Restless Legs Syndrome 6

MalaCards organs/tissues related to Restless Legs Syndrome 6:

⁴¹

Heart

Sources

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

(show all 17)

#	Title	Authors	Year
1	Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. ( 30554649 )	Xie J...Caples SM	2018
2	The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep. ( 28837991 )		2017
3	Incident Cardiovascular Events and Death in Individuals With Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review. ( 28329227 )	Kendzerska T...Boulos MI	2017
4	Restless leg syndrome and periodic limb movements in sleep: risk for cardiovascular disease. ( 28457801 )	Kawada T	2017
5	Post-stroke restless leg syndrome and periodic limb movements in sleep. ( 26932899 )	Woo HG...Ahn TB	2017
6	Evaluation of Periodic Limb Movements in Sleep and Iron Status in Children With Autism. ( 26231264 )	Lane R....Felt B.	2015
7	Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements in Sleep in the Elderly with and without Dementia. ( 26329443 )	Figorilli M...Ferri R	2015
8	Further thoughts on "The Restless Legs Syndrome: Would You Like that with Movements or Without?": Summary of Evidence that the Presence of Periodic Limb Movements in Sleep Does Not Significantly Aid in the Diagnosis of Restless Legs Syndrome/Willis-Ekbom Disease. ( 26175957 )	Walters AS	2015
9	The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )	Kobayashi M....Inoue Y.	2014
10	Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity. ( 25129262 )	Winkelman JW...Jensen JE	2014
11	Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire. ( 24246378 )	Allen R....Kohnen R.	2013
12	Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. ( 23372468 )		2013
13	L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. ( 21463967 )	England S.J....Walters A.S.	2011
14	Remission of severe restless legs syndrome and periodic limb movements in sleep after bilateral excision of multiple foot neuromas: a case report. ( 20849622 )		2010
15	A genetic risk factor for periodic limb movements in sleep. ( 18216367 )	Vilarino-Guell C....Lin S.C.	2008
16	Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )	Vetrugno R....Montagna P.	2007
17	A genetic risk factor for periodic limb movements in sleep. ( 17634447 )		2007

Sources

Genes for Restless Legs Syndrome 6

Genes related to Restless Legs Syndrome 6 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	RLS6	Restless Legs Syndrome, Susceptibility To, 6	Genetic Locus	50	Genetic linkage ⁵⁷ Susceptibility factor ⁵⁷
2	BTBD9	BTB Domain Containing 9	Protein Coding	18.27	GeneCards inferred via : Disorders (show sections)

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Variations for Restless Legs Syndrome 6

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Expression for Restless Legs Syndrome 6

Search GEO for disease gene expression data for Restless Legs Syndrome 6.

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Pathways for Restless Legs Syndrome 6

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GO Terms for Restless Legs Syndrome 6

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Sources for Restless Legs Syndrome 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Restless Legs Syndrome 6 (RLS6)

Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Classifications:

External Ids:

Summaries for Restless Legs Syndrome 6

Related Diseases for Restless Legs Syndrome 6

Diseases in the Restless Legs Syndrome family:

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM:

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Restless Legs Syndrome 6

Anatomical Context for Restless Legs Syndrome 6

MalaCards organs/tissues related to Restless Legs Syndrome 6:

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

Genes for Restless Legs Syndrome 6

Genes related to Restless Legs Syndrome 6 (1 elite genes):

Variations for Restless Legs Syndrome 6

Expression for Restless Legs Syndrome 6

Pathways for Restless Legs Syndrome 6

GO Terms for Restless Legs Syndrome 6

Sources for Restless Legs Syndrome 6