RLS6
MCID: RST020
MIFTS: 26

Restless Legs Syndrome 6 (RLS6)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Name: Restless Legs Syndrome 6 57 75
Restless Legs Syndrome, Susceptibility to, 6 57 53 13
Rls6 57 53 75
Periodic Limb Movements in Sleep 57 53

Classifications:



External Ids:

OMIM 57 611185
MedGen 42 C1970020
MeSH 44 D012148

Summaries for Restless Legs Syndrome 6

OMIM : 57 Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Limb movements during sleep are more common in otherwise asymptomatic family members of patients with RLS compared to the general population (Stefansson et al., 2007). Thus, periodic limb movements during sleep may serve as an endophenotype for RLS. However, not all patients with RLS have limb movements during sleep, and the majority of individuals with limb movements during sleep do not have waking symptoms of RLS (Winkelman, 2007). For additional information and a discussion of genetic heterogeneity of RLS, see RLS1 (102300). (611185)

MalaCards based summary : Restless Legs Syndrome 6, also known as restless legs syndrome, susceptibility to, 6, is related to restless legs syndrome and periodic limb movement disorder. An important gene associated with Restless Legs Syndrome 6 is RLS6 (Restless Legs Syndrome, Susceptibility To, 6). The drugs Rotigotine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart.

UniProtKB/Swiss-Prot : 75 Restless legs syndrome 6: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

Related Diseases for Restless Legs Syndrome 6

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1 Restless Legs Syndrome 2
Restless Legs Syndrome 3 Restless Legs Syndrome 4
Restless Legs Syndrome 6 Restless Legs Syndrome 5
Restless Legs Syndrome 7 Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 32.2 BTBD9 RLS6
2 periodic limb movement disorder 11.5
3 restless legs syndrome 7 11.1
4 attention deficit-hyperactivity disorder 10.0
5 williams-beuren syndrome 10.0
6 autism 10.0
7 congestive heart failure 10.0
8 dementia 10.0
9 sickle cell disease 10.0

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:



Diseases related to Restless Legs Syndrome 6

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM:

611185

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rotigotine Approved Phase 4,Phase 3 99755-59-6, 92206-54-7 57537
2
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
3
Pramipexole Approved, Investigational Phase 4 104632-26-0 119570 59868
4 Dopamine Agents Phase 4,Phase 3
5 Dopamine agonists Phase 4,Phase 3
6 Neurotransmitter Agents Phase 4,Phase 3
7 Antioxidants Phase 4
8 Antiparkinson Agents Phase 4
9 Protective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome Completed NCT01455012 Phase 4 Rotigotine;Placebo
2 Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS) Completed NCT00472199 Phase 4 Pramipexole;Placebo
3 DIalysis Symptom COntrol-Restless Legs Syndrome Trial Not yet recruiting NCT03806530 Phase 3 Gabapentin;Ropinirole;Placebo Gabapentin;Placebo Ropinirole
4 Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS) Completed NCT01569464 Phase 3 Rotigotine
5 Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS) Completed NCT00887289

Search NIH Clinical Center for Restless Legs Syndrome 6

Genetic Tests for Restless Legs Syndrome 6

Anatomical Context for Restless Legs Syndrome 6

MalaCards organs/tissues related to Restless Legs Syndrome 6:

41
Heart

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

(show all 17)
# Title Authors Year
1
Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. ( 30554649 )
2018
2
The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep. ( 28837991 )
2017
3
Incident Cardiovascular Events and Death in Individuals With Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review. ( 28329227 )
2017
4
Restless leg syndrome and periodic limb movements in sleep: risk for cardiovascular disease. ( 28457801 )
2017
5
Post-stroke restless leg syndrome and periodic limb movements in sleep. ( 26932899 )
2017
6
Evaluation of Periodic Limb Movements in Sleep and Iron Status in Children With Autism. ( 26231264 )
2015
7
Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements in Sleep in the Elderly with and without Dementia. ( 26329443 )
2015
8
Further thoughts on "The Restless Legs Syndrome: Would You Like that with Movements or Without?": Summary of Evidence that the Presence of Periodic Limb Movements in Sleep Does Not Significantly Aid in the Diagnosis of Restless Legs Syndrome/Willis-Ekbom Disease. ( 26175957 )
2015
9
The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )
2014
10
Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity. ( 25129262 )
2014
11
Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire. ( 24246378 )
2013
12
Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. ( 23372468 )
2013
13
L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. ( 21463967 )
2011
14
Remission of severe restless legs syndrome and periodic limb movements in sleep after bilateral excision of multiple foot neuromas: a case report. ( 20849622 )
2010
15
A genetic risk factor for periodic limb movements in sleep. ( 18216367 )
2008
16
Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )
2007
17
A genetic risk factor for periodic limb movements in sleep. ( 17634447 )
2007

Variations for Restless Legs Syndrome 6

Expression for Restless Legs Syndrome 6

Search GEO for disease gene expression data for Restless Legs Syndrome 6.

Pathways for Restless Legs Syndrome 6

GO Terms for Restless Legs Syndrome 6

Sources for Restless Legs Syndrome 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....