Restless Legs Syndrome 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Name: Restless Legs Syndrome 6 ⁵⁷ ⁷² ¹³

Rls6 ⁵⁷ ²⁰ ⁷²

Restless Legs Syndrome, Susceptibility to, 6 ⁵⁷ ²⁰

Periodic Limb Movements in Sleep ⁵⁷ ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 611185

OMIM Phenotypic Series ⁵⁷ PS102300

MeSH ⁴⁴ D012148

MedGen ⁴¹ C1970020

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Summaries for Restless Legs Syndrome 6

OMIM® : ⁵⁷ Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Limb movements during sleep are more common in otherwise asymptomatic family members of patients with RLS compared to the general population (Stefansson et al., 2007). Thus, periodic limb movements during sleep may serve as an endophenotype for RLS. However, not all patients with RLS have limb movements during sleep, and the majority of individuals with limb movements during sleep do not have waking symptoms of RLS (Winkelman, 2007). For additional information and a discussion of genetic heterogeneity of RLS, see RLS1 (102300). (611185) (Updated 05-Apr-2021)

MalaCards based summary : Restless Legs Syndrome 6, also known as rls6, is related to restless legs syndrome and restless legs syndrome 7. An important gene associated with Restless Legs Syndrome 6 is RLS6 (Restless Legs Syndrome, Susceptibility To, 6). The drugs Dopamine and Iron have been mentioned in the context of this disorder.

UniProtKB/Swiss-Prot : ⁷² Restless legs syndrome 6: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

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Related Diseases for Restless Legs Syndrome 6

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1	Restless Legs Syndrome 2
Restless Legs Syndrome 3	Restless Legs Syndrome 4
Restless Legs Syndrome 6	Restless Legs Syndrome 5
Restless Legs Syndrome 7	Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)

#	Related Disease	Score	Top Affiliating Genes
1	restless legs syndrome	29.3	RLS6 BTBD9
2	restless legs syndrome 7	11.3
3	sleep disorder	10.6
4	sleep apnea	10.5
5	periodic limb movement disorder	10.5
6	attention deficit-hyperactivity disorder	10.4
7	iron metabolism disease	10.4
8	heart disease	10.3
9	dementia	10.3
10	kidney disease	10.3
11	cerebrovascular disease	10.3
12	parkinson disease, late-onset	10.1
13	autism	10.1
14	moyamoya disease 1	10.1
15	tardive dyskinesia	10.1
16	coronary heart disease 1	10.1
17	major depressive disorder	10.1
18	autism 18	10.1
19	mental depression	10.1
20	neuroma	10.1
21	uremia	10.1
22	congestive heart failure	10.1
23	end stage renal disease	10.1
24	chronic kidney disease	10.1
25	central sleep apnea	10.1
26	sickle cell disease	10.1
27	depression	10.1
28	myoclonus	10.1
29	tremor	10.1

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:

Sources

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM®:

611185 (Updated 05-Apr-2021)

Sources

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Dopamine

Approved

62-31-7, 51-61-6

681

Synonyms:

(3H)-Dopamine

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-dihydroxyphenyl)ethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

2-benzenediol

3,4 Dihydroxyphenethylamine

3,4-dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)catechol

4-(2-Aminoethyl)catechol

4-(2-aminoethyl)pyrocatechol

4-(2-aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

a-(3,4-Dihydroxyphenyl)-b-aminoethane

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

ASL 279

BIDD:ER0506

Biomol-NT_000001

BPBio1_001123

BSPBio_001932

C03758

CHEBI:18243

CHEMBL59

CID681

cMAP_000036

cMAP_000065

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

dopamine

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopamine hydrochloride

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydrochloride, dopamine

Hydroxytyramin

hydroxytyramine

Hydroxytyramine

IDI1_000780

intropin

Intropin

Intropin [*hydrochloride*]

IP 498

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L000232

L-DOPAMINE

LDP

Lopac0_000586

Lopac-H-8502

LS-159

Medopa

Medopa (TN)

m-Hydroxytyramine hydrochloride

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

Spectrum_001012

SPECTRUM1505155

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

ST048774

STK301601

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

2

Iron

Approved

7439-89-6

23925 29936

Synonyms:

02583_FLUKA

12310_ALDRICH

12310_RIEDEL

129048-51-7

14067-02-8

161135-39-3

190454-13-8

195161-83-2

199281-22-6

209309_ALDRICH

209309_SIAL

255637_ALDRICH

266213_ALDRICH

266256_ALDRICH

267945_ALDRICH

267953_ALDRICH

26Fe

338141_ALDRICH

356808_ALDRICH

356824_ALDRICH

356832_ALDRICH

39344-71-3

3ZhP

413054_ALDRICH

443783-52-6

44890_ALDRICH

44890_FLUKA

675141-17-0

70884-35-4

73135-38-3

7439-89-6

8011-79-8

8053-60-9

AC1L2N38

Ancor B

Ancor en 80/150

Armco iron

Atomel 28

Atomel 300M200

Atomel 500M

Atomel 95

Atomiron 44MR

Atomiron 5M

Atomiron AFP 25

Atomiron AFP 5

ATW 230

ATW 432

C00023

C3518_SIAL

C3518_SIGMA

Carbonyl iron

CCRIS 1580

CHEBI:18248

CID23925

Copy Powder CS 105-175

D007501

DB01592

Diseases (animal), iron overload

Diseases, iron overload

DSP 1000

DSP 128B

DSP 135

DSP 135C

DSP 138

Ed-In-Sol

EF 1000

EF 250

EFV 200/300

EFV 250

EFV 250/400

EINECS 231-096-4

Eisen

Electrolytic iron

F 60 (metal)

Fe

FE

FE (III) ion

Fe(3+)

Fe(III)

Fe1+

Fe-40

fer

Feronate

Ferretts

Ferric ion

Ferric iron

Ferro-Caps

Ferro-Time

ferrous iron

Ferrousal

Ferrovac E

Ferrum

Ferrum metallicum

FT 3 (element)

GS 6

Hemocyte

HF 2 (element)

hierro

Hierro

HL (iron)

Hoeganaes ATW 230

Hoeganaes EH

HQ (metal)

HS (iron)

HS 4849

HSDB 604

IRMM524A_FLUKA

IRMM524B_FLUKA

IRON

Iron (Fe)

Iron (Fe1+)

Iron ion (Fe+)

Iron ion(1+)

Iron monocation

Iron powder

Iron standard for AAS

Iron(1+)

Iron(1+) ion

Iron(3+)

Iron(III) nitrate solution

Iron, carbonyl

Iron, electrolytic

Iron, elemental

Iron, ion (fe(3+))

Iron, ion (Fe1+)

Iron, ion (Fe1+) (8CI,9CI)

Iron, reduced

LOHA

LS-3196

MolPort-003-925-001

NC 100

PZh1M1

PZh-1M3

PZh-2

PZh2M

PZh2M1

PZh2M2

PZh3

PZh3M

PZh4M

PZhO

Reduced iron

Remko

Siderol

SUY-B 2

UNII-E1UOL152H7

Vitedyn-Slo

Yieronia

3

Iron Supplement

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Dopamine Transporter Density Profiles Assessed by Tc-TRODAT and SPECT in Patients With Periodic Limb Movements	Completed	NCT01365364
2	Impact of Iron Supplementation Treatment on Brain Iron Concentrations Among Children With ADHD & Restless Leg Syndrome Combined With Periodic Limb Movements in Sleep	Not yet recruiting	NCT04144790

Search NIH Clinical Center for Restless Legs Syndrome 6

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Genetic Tests for Restless Legs Syndrome 6

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Anatomical Context for Restless Legs Syndrome 6

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Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

(show all 14)

#	Title	Authors	PMID	Year
1	MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease. ⁵⁷	Schormair B...Winkelmann J	21572129	2011
2	MEIS1 p.R272H in familial restless legs syndrome. ⁵⁷	Vilarino-Guell C...Lin SC	19620614	2009
3	Replication of restless legs syndrome loci in three European populations. ⁵⁷	Kemlink D...Winkelmann J	19279021	2009
4	A genetic risk factor for periodic limb movements in sleep. ⁵⁷	Vilarino-Guell C...Lin SC	18216367	2008
5	A genetic risk factor for periodic limb movements in sleep. ⁵⁷	Stefansson H...Stefansson K	17634447	2007
6	Periodic limb movements in sleep--endophenotype for restless legs syndrome? ⁵⁷	Winkelman JW	17634452	2007
7	Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. ⁵⁷	Winkelmann J...Meitinger T	17637780	2007
8	The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) Trial: A Protocol for a Randomized, Crossover, Placebo-Controlled Blinded Trial. ⁶¹	Collister D...Walsh M	33294203	2020
9	The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare. ⁶¹	Bener A...Omer A	31879618	2019
10	A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders. ⁶¹	Kurtis MM...Martinez-Martin P	29896152	2018
11	Validation of the Kohnen Restless Legs Syndrome-Quality of Life instrument. ⁶¹	Kohnen R...Walters AS	27810174	2016
12	Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease. ⁶¹	Kohnen R...Walters AS	27318235	2016
13	Post Hoc Analysis of Data from Two Clinical Trials Evaluating the Minimal Clinically Important Change in International Restless Legs Syndrome Sum Score in Patients with Restless Legs Syndrome (Willis-Ekbom Disease). ⁶¹	Ondo WG...Roth T	26446245	2016
14	Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire. ⁶¹	Allen R...Kohnen R	24246378	2013

Sources

Genes for Restless Legs Syndrome 6

Genes related to Restless Legs Syndrome 6 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RLS6	Restless Legs Syndrome, Susceptibility To, 6	Genetic Locus	50	Genetic linkage ⁵⁷ Susceptibility factor ⁵⁷
2	BTBD9	BTB Domain Containing 9	Protein Coding	7.92	GeneCards inferred via : Disorders (show sections)

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Variations for Restless Legs Syndrome 6

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Expression for Restless Legs Syndrome 6

Search GEO for disease gene expression data for Restless Legs Syndrome 6.

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Pathways for Restless Legs Syndrome 6

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GO Terms for Restless Legs Syndrome 6

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Sources for Restless Legs Syndrome 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Restless Legs Syndrome 6 (RLS6)

Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Classifications:

External Ids:

Summaries for Restless Legs Syndrome 6

Related Diseases for Restless Legs Syndrome 6

Diseases in the Restless Legs Syndrome family:

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Restless Legs Syndrome 6:

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM®:

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Restless Legs Syndrome 6

Anatomical Context for Restless Legs Syndrome 6

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

Genes for Restless Legs Syndrome 6

Genes related to Restless Legs Syndrome 6 (1 elite genes):

Variations for Restless Legs Syndrome 6

Expression for Restless Legs Syndrome 6

Pathways for Restless Legs Syndrome 6

GO Terms for Restless Legs Syndrome 6

Sources for Restless Legs Syndrome 6