RLS7
MCID: RST016
MIFTS: 15

Restless Legs Syndrome 7 (RLS7)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Restless Legs Syndrome 7

MalaCards integrated aliases for Restless Legs Syndrome 7:

Name: Restless Legs Syndrome 7 56 73 13
Rls7 56 73
Restless Legs Syndrome, Susceptibility to, 7 56

Classifications:



External Ids:

OMIM 56 612853
OMIM Phenotypic Series 56 PS102300
MeSH 43 D012148
MedGen 41 C2748506

Summaries for Restless Legs Syndrome 7

UniProtKB/Swiss-Prot : 73 Restless legs syndrome 7: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

MalaCards based summary : Restless Legs Syndrome 7, also known as rls7, is related to restless legs syndrome. An important gene associated with Restless Legs Syndrome 7 is RLS7 (Restless Legs Syndrome 7). Affiliated tissues include testes.

OMIM : 56 Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). For additional information and a discussion of genetic heterogeneity of restless legs syndrome, see RLS1 (102300). (612853)

Related Diseases for Restless Legs Syndrome 7

Diseases in the Restless Legs Syndrome family:

Restless Legs Syndrome 1 Restless Legs Syndrome 2
Restless Legs Syndrome 3 Restless Legs Syndrome 4
Restless Legs Syndrome 6 Restless Legs Syndrome 5
Restless Legs Syndrome 7 Restless Legs Syndrome 8

Diseases related to Restless Legs Syndrome 7 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 31.8 RLS7 MEIS1

Symptoms & Phenotypes for Restless Legs Syndrome 7

Clinical features from OMIM:

612853

Drugs & Therapeutics for Restless Legs Syndrome 7

Search Clinical Trials , NIH Clinical Center for Restless Legs Syndrome 7

Genetic Tests for Restless Legs Syndrome 7

Anatomical Context for Restless Legs Syndrome 7

MalaCards organs/tissues related to Restless Legs Syndrome 7:

40
Testes

Publications for Restless Legs Syndrome 7

Articles related to Restless Legs Syndrome 7:

# Title Authors PMID Year
1
Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. 56
24995868 2014
2
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. 56
24642863 2014
3
MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease. 56
21572129 2011
4
MEIS1 p.R272H in familial restless legs syndrome. 56
19620614 2009
5
Replication of restless legs syndrome loci in three European populations. 56
19279021 2009
6
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. 56
19126776 2009
7
A genetic risk factor for periodic limb movements in sleep. 56
18216367 2008
8
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 56
17637780 2007
9
Autosomal dominant restless legs syndrome maps on chromosome 14q. 56
12764067 2003

Variations for Restless Legs Syndrome 7

Expression for Restless Legs Syndrome 7

Search GEO for disease gene expression data for Restless Legs Syndrome 7.

Pathways for Restless Legs Syndrome 7

GO Terms for Restless Legs Syndrome 7

Sources for Restless Legs Syndrome 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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