Rete Testis Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rete Testis Neoplasm

MalaCards integrated aliases for Rete Testis Neoplasm:

Name: Rete Testis Neoplasm ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5639

NCIt ⁵⁰ C39955

UMLS ⁷³ C1514912

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Summaries for Rete Testis Neoplasm

MalaCards based summary : Rete Testis Neoplasm is related to rete testis adenocarcinoma and nephrogenic adenoma of urinary bladder. An important gene associated with Rete Testis Neoplasm is PAX2 (Paired Box 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Adhesion. Affiliated tissues include testis.

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Related Diseases for Rete Testis Neoplasm

Diseases related to Rete Testis Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)

#	Related Disease	Score	Top Affiliating Genes
1	rete testis adenocarcinoma	25.9	AFP CALB2 CEACAM5 ENO2 KIT KLK3
2	nephrogenic adenoma of urinary bladder	11.0	PAX2 PAX8
3	bladder benign neoplasm	11.0	PAX2 PAX8
4	endosalpingiosis	10.9	PAX8 PTGER4
5	mature teratoma of the ovary	10.9	ENO2 KRT20
6	cystic basal cell carcinoma	10.9	KRT20 PTGER4
7	malignant sertoli cell tumor	10.9	AFP ENO2
8	goblet cell carcinoid	10.9	ENO2 KRT20
9	malignant syringoma	10.8	KRT20 PTGER4
10	basal cell carcinoma, infundibulocystic	10.8	KRT20 PTGER4
11	athyreosis	10.8	NKX2-1 PAX8
12	renal pelvis adenocarcinoma	10.8	AFP PAX8
13	lung acinar adenocarcinoma	10.8	KRT20 NKX2-1
14	malignant epithelial mesothelioma	10.8	PTGER4 THBD
15	peritoneum cancer	10.8	PAX8 PTGER4
16	prostate small cell carcinoma	10.8	ENO2 KLK3
17	ovarian germ cell cancer	10.7	AFP NKX2-1
18	head injury	10.7	ENO2 THBD
19	hypothyroidism, congenital, nongoitrous, 2	10.7	NKX2-1 PAX8
20	respiratory system benign neoplasm	10.7	ENO2 NKX2-1
21	seminal vesicle adenocarcinoma	10.7	KLK3 KRT20
22	nodular prostate	10.7	ENO2 KLK3
23	retinal hemangioblastoma	10.7	ENO2 PAX2 PAX8
24	renal pelvis carcinoma	10.7	KRT20 PAX8
25	clear cell hidradenoma	10.7	MME PAX8
26	malignant struma ovarii	10.7	AFP NKX2-1
27	multiple mucosal neuroma	10.7	ENO2 NCAM1
28	tuberculous epididymitis	10.6	AFP KLK3
29	carcinoid tumors, intestinal	10.6	ENO2 NKX2-1
30	endocervical adenocarcinoma	10.6	KRT20 PAX2 PAX8
31	adenocarcinoma in situ	10.6	KRT20 PAX2 PAX8
32	lung meningioma	10.6	ENO2 NCAM1
33	epididymis cancer	10.6	CEACAM5 PTGER4
34	epididymis adenocarcinoma	10.6	CEACAM5 PTGER4
35	sensory organ benign neoplasm	10.6	ENO2 NCAM1
36	renal adenoma	10.6	NCAM1 PAX2
37	gallbladder small cell carcinoma	10.6	ENO2 NCAM1
38	urethra adenocarcinoma	10.6	KLK3 PAX8
39	sarcomatoid mesothelioma	10.6	NKX2-1 THBD
40	choriocarcinoma of ovary	10.6	ENO2 NCAM1
41	urethra clear cell adenocarcinoma	10.6	KLK3 PAX8
42	orbital cancer	10.6	ENO2 NCAM1
43	childhood endodermal sinus tumor	10.6	AFP PAX2 PAX8
44	atypical follicular adenoma	10.6	CEACAM5 ENO2
45	ovarian large-cell neuroendocrine carcinoma	10.6	KRT20 NCAM1
46	bladder lymphoma	10.6	KRT20 MME
47	small cell carcinoma of the bladder	10.6	ENO2 KRT20 NKX2-1
48	cystic teratoma	10.6	ENO2 KRT20 NKX2-1
49	mucinous cystadenofibroma	10.6	AFP CEACAM5
50	urachal adenocarcinoma	10.6	AFP CEACAM5

Graphical network of the top 20 diseases related to Rete Testis Neoplasm:

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Symptoms & Phenotypes for Rete Testis Neoplasm

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Drugs & Therapeutics for Rete Testis Neoplasm

Search Clinical Trials , NIH Clinical Center for Rete Testis Neoplasm

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Genetic Tests for Rete Testis Neoplasm

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Anatomical Context for Rete Testis Neoplasm

MalaCards organs/tissues related to Rete Testis Neoplasm:

⁴¹

Testis

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Publications for Rete Testis Neoplasm

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Genes for Rete Testis Neoplasm

Genes related to Rete Testis Neoplasm (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAX2	Paired Box 2	Protein Coding	14.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	ENO2	Enolase 2	Protein Coding	14.37	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PAX8	Paired Box 8	Protein Coding	14.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PTGER4	Prostaglandin E Receptor 4	Protein Coding	14.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT20	Keratin 20	Protein Coding	14.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	NKX2-1	NK2 Homeobox 1	Protein Coding	14.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	AFP	Alpha Fetoprotein	Protein Coding	13.91	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	THBD	Thrombomodulin	Protein Coding	13.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KLK3	Kallikrein Related Peptidase 3	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	MME	Membrane Metalloendopeptidase	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CALB2	Calbindin 2	Protein Coding	5.17	DISEASES inferred ¹⁵
14	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	4.51	DISEASES inferred ¹⁵

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Variations for Rete Testis Neoplasm

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Expression for Rete Testis Neoplasm

Search GEO for disease gene expression data for Rete Testis Neoplasm.

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Pathways for Rete Testis Neoplasm

Pathways related to Rete Testis Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.62	AFP NCAM1 PAX2
2	Adhesion ⁴	11.52	CEACAM5 KLK3 NCAM1
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.32	CEACAM5 KIT MME NCAM1
4	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.79	KIT MME NCAM1 THBD
5	ID signaling pathway ¹	10.36	PAX2 PAX8

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GO Terms for Rete Testis Neoplasm

Biological processes related to Rete Testis Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	thyroid gland development	GO:0030878	9.58	NKX2-1 PAX8
2	positive regulation of branching involved in ureteric bud morphogenesis	GO:0090190	9.57	PAX2 PAX8
3	negative regulation of programmed cell death	GO:0043069	9.56	KIT PAX2
4	urogenital system development	GO:0001655	9.55	PAX2 PAX8
5	mesonephros development	GO:0001823	9.54	PAX2 PAX8
6	mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0003337	9.52	PAX2 PAX8
7	pronephros development	GO:0048793	9.51	PAX2 PAX8
8	regulation of metanephric nephron tubule epithelial cell differentiation	GO:0072307	9.49	PAX2 PAX8
9	metanephric epithelium development	GO:0072207	9.48	PAX2 PAX8
10	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0072108	9.46	PAX2 PAX8
11	metanephric nephron tubule formation	GO:0072289	9.43	PAX2 PAX8
12	metanephric distal convoluted tubule development	GO:0072221	9.4	PAX2 PAX8
13	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900212	9.37	PAX2 PAX8
14	pronephric field specification	GO:0039003	9.32	PAX2 PAX8
15	positive regulation of metanephric DCT cell differentiation	GO:2000594	9.26	PAX2 PAX8
16	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	GO:0072305	9.16	PAX2 PAX8
17	negative regulation of apoptotic process involved in metanephric collecting duct development	GO:1900215	8.96	PAX2 PAX8
18	negative regulation of apoptotic process involved in metanephric nephron tubule development	GO:1900218	8.62	PAX2 PAX8

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Sources for Rete Testis Neoplasm

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