Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: RTC012
MIFTS: 39

Reticuloendotheliosis, X-Linked

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Reticuloendotheliosis, X-Linked

About this section

MalaCards integrated aliases for Reticuloendotheliosis, X-Linked:

Name: Reticuloendotheliosis, X-Linked 56 52
Reticuloendotheliosis 52 54

Characteristics:

OMIM:

56
Inheritance:
x-linked


HPO:

31
reticuloendotheliosis, x-linked:
Inheritance x-linked inheritance
Onset and clinical course infantile onset


Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 56 312500
MedGen 41 C0035288
Sources

Summaries for Reticuloendotheliosis, X-Linked

About this section
MalaCards based summary : Reticuloendotheliosis, X-Linked, also known as reticuloendotheliosis, is related to rabies and intrapelvic lymph node leukemic reticuloendotheliosis. An important gene associated with Reticuloendotheliosis, X-Linked is RELA (RELA Proto-Oncogene, NF-KB Subunit), and among its related pathways/superpathways are Ras signaling pathway and Downstream signaling events of B Cell Receptor (BCR). The drugs Vorinostat and Bortezomib have been mentioned in the context of this disorder. Affiliated tissues include spleen, t cells and bone, and related phenotypes are anemia and jaundice

More information from OMIM: 312500
Sources

Related Diseases for Reticuloendotheliosis, X-Linked

About this section

Diseases related to Reticuloendotheliosis, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 rabies 29.1 RELA REL
2 intrapelvic lymph node leukemic reticuloendotheliosis 12.3
3 omenn syndrome 11.8
4 hairy cell leukemia 11.7
5 classic hairy cell leukemia 11.7
6 histoplasmosis 11.5
7 leukemia 10.6
8 letterer-siwe disease 10.6
9 lymphoma 10.5
10 melanoma tumor antigen gp90 10.5
11 acute leukemia 10.4
12 newcastle disease 10.4
13 hypereosinophilic syndrome 10.3
14 splenomegaly 10.3
15 histiocytosis 10.3
16 avian influenza 10.3
17 langerhans cell histiocytosis 10.3
18 diarrhea 10.3
19 thrombocytopenia 10.3
20 mycosis fungoides 10.2
21 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.2
22 deficiency anemia 10.2
23 neutropenia 10.2
24 monocytic leukemia 10.2
25 leukemia, chronic lymphocytic 10.2
26 sarcoma 10.2
27 pancytopenia 10.2
28 spindle cell sarcoma 10.2
29 hemolytic anemia 10.2
30 hypersplenism 10.2
31 stomatitis 10.2
32 granulocytopenia 10.2
33 lymphosarcoma 10.2
34 marek disease 10.2
35 erythroleukemia, familial 10.1
36 immune deficiency disease 10.1
37 bacterial infectious disease 10.1
38 gaucher's disease 10.1
39 b-cell lymphoma 10.1
40 vasculitis 10.1
41 follicular mucinosis 10.1
42 eosinophilia, familial 9.9
43 keratitis, hereditary 9.9
44 sarcoidosis 1 9.9
45 torticollis 9.9
46 triiodothyronine receptor auxiliary protein 9.9
47 anemia, autoimmune hemolytic 9.9
48 hemophagocytic lymphohistiocytosis, familial, 1 9.9
49 reticulum cell sarcoma 9.9
50 sjogren syndrome 9.9

Graphical network of the top 20 diseases related to Reticuloendotheliosis, X-Linked:



Diseases related to Reticuloendotheliosis, X-Linked
Sources

Symptoms & Phenotypes for Reticuloendotheliosis, X-Linked

About this section

Human phenotypes related to Reticuloendotheliosis, X-Linked:

31
# Description HPO Frequency HPO Source Accession
1 anemia 31 HP:0001903
2 jaundice 31 HP:0000952
3 lymphadenopathy 31 HP:0002716
4 hepatosplenomegaly 31 HP:0001433

Symptoms via clinical synopsis from OMIM:

56
Heme:
anemia
lymphadenopathy
malignant reticuloendotheliosis

Misc:
infantile onset

G I:
jaundice
hepatosplenomegaly

Clinical features from OMIM:

312500
Sources

Drugs & Therapeutics for Reticuloendotheliosis, X-Linked

About this section

Drugs for Reticuloendotheliosis, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
2
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
3
ofatumumab Approved Phase 2 679818-59-8 6918251
4 Histone Deacetylase Inhibitors Phase 2
5 Immunoglobulins Phase 2
6 Immunologic Factors Phase 2
7 Antibodies Phase 2
8 Fluorides Phase 2
9 Anti-Infective Agents Phase 2
10 Antibodies, Monoclonal Phase 2
11 Alkylating Agents Phase 2
12 Fluorodeoxyglucose F18 Phase 2
13 Deoxyglucose Phase 2
14 Radiopharmaceuticals Phase 2
15 Antiviral Agents Phase 2
16 Antimetabolites Phase 2
17 Bendamustine Hydrochloride Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial of Bortezomib and Vorinostat in Mantle Cell and Diffuse Large B-Cell Lymphomas Completed NCT00703664 Phase 2 Bortezomib;Vorinostat
2 A Randomized Phase II Trial of Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib (NSC # 681239) and Bendamustine in Patients With Untreated Follicular Lymphoma Active, not recruiting NCT01286272 Phase 2 Bendamustine Hydrochloride;Bortezomib

Search NIH Clinical Center for Reticuloendotheliosis, X-Linked

Sources

Genetic Tests for Reticuloendotheliosis, X-Linked

About this section
Sources

Anatomical Context for Reticuloendotheliosis, X-Linked

About this section

MalaCards organs/tissues related to Reticuloendotheliosis, X-Linked:

40
Spleen, T Cells, Bone, B Cells, Bone Marrow, Monocytes, Testes
Sources

Publications for Reticuloendotheliosis, X-Linked

About this section

Articles related to Reticuloendotheliosis, X-Linked:

(show top 50) (show all 1101)
# Title Authors PMID Year
1
A fatal x-linked recessive reticuloendothelial syndrome with hyperglobulinemia. X-linked recessive reticuloendotheliosis. 61 56
4199726 1973
2
Effects of gamma-secretase inhibitors on the growth of leukemia cells. 61 54
20332460 2010
3
Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. 61 54
17804543 2007
4
Identification of genes related to nasopharyngeal carcinoma with the help of pathway-based networks. 61 54
17151784 2006
5
Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies. 61 54
16556680 2006
6
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. 54 61
15870177 2005
7
Interaction of the v-rel protein with an NF-kappa B DNA binding site. 61 54
1848011 1991
8
An atypical clinicopathological manifestation of fowl poxvirus associated with reticuloendotheliosis virus in commercial laying hen flocks in Brazil. 61
32519513 2020
9
Changes in the Percentages of B- and T-Lymphocytes and Antibody Titres in Laying Hens Infested with Dermanyssus gallinae-A Preliminary Study. 61
32517104 2020
10
Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway. 61
32572944 2020
11
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis. 61
31462144 2020
12
Isolation and pathogenicity testing of avian reticuloendotheliosis virus from layer chickens in China. 61
32233842 2020
13
Avian leukosis virus subgroup J and reticuloendotheliosis virus coinfection induced TRIM62 regulation of the actin cytoskeleton. 61
32476322 2020
14
Feed‑back loops integrating RELA, SOX18 and FAK mediate the break‑down of the lymph‑endothelial barrier that is triggered by 12(S)‑HETE. 61
32319559 2020
15
Potential Role of Macrophage Migration Inhibitory Factor in the Pathogenesis of Marek's Disease. 61
32258797 2020
16
Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection. 61
32122614 2020
17
First report on molecular characterization and phylogenetic analysis of Reticuloendotheliosis virus in Sudan. 61
32040658 2020
18
MMP9, CXCR1, TLR6, and MPO participant in the progression of coronary artery disease. 61
32052443 2020
19
Exosomes derived from human umbilical cord mesenchymal stem cells repair injured endometrial epithelial cells. 61
31938932 2020
20
Emergence of spontaneously occurring neoplastic disease caused by reticuloendotheliosis virus in breeding Muscovy ducks in China, 2019. 61
32068970 2020
21
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. 61
31286804 2020
22
Detection of Reticuloendotheliosis Virus in Muscovy Ducks, Wild Turkeys, and Chickens in Brazil. 61
31917630 2020
23
TRIM62 From Chicken as a Negative Regulator of Reticuloendotheliosis Virus Replication. 61
32318585 2020
24
Proteome analysis of reticuloendotheliosis-virus-infected chicken embryo fibroblast cells through iTRAQ-based quantitative proteomics. 61
31576460 2019
25
Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice. 61
31539516 2019
26
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway. 61
31817701 2019
27
The Roles of MicroRNAs (miRNAs) in Avian Response to Viral Infection and Pathogenesis of Avian Immunosuppressive Diseases. 61
31683847 2019
28
Multicentric Round Cell Neoplasms and Their Viral Associations in Wild Turkeys (Meleagris gallopavo) in the Southeastern United States. 61
31345138 2019
29
Detection and Molecular Characterization of a Natural Coinfection of Marek's Disease Virus and Reticuloendotheliosis Virus in Brazilian Backyard Chicken Flock. 61
31756886 2019
30
Serological and molecular identification of Reticuloendotheliosis virus (REV) in chickens in Sudan. 61
31347279 2019
31
Transcriptional analysis of host responses related to immunity in chicken spleen tissues infected with reticuloendotheliosis virus strain SNV. 61
31228642 2019
32
A high frequency of Gallid herpesvirus-2 co-infection with Reticuloendotheliosis virusis associated with high tumor rates in Chinese chicken farms. 61
31585637 2019
33
Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial. 61
30976811 2019
34
Lymphoproliferative Disease Virus in Wild Turkeys (Meleagris gallopavo) from Manitoba and Quebec, Canada. 61
31967435 2019
35
Histologic findings and viral antigen distribution in natural coinfection of layer hens with subgroup J avian leukosis virus, Marek's disease virus, and reticuloendotheliosis virus. 61
31378167 2019
36
Changes in apoptosis, proliferation and T lymphocyte subtype on thymic cells of SPF chickens infected with reticuloendotheliosis virus. 61
31048099 2019
37
Clinical significance of the histological and molecular characteristics of ependymal tumors: a single institution case series from China. 61
31324163 2019
38
Inhibitory Effect of Jing-Fang Powder n-Butanol Extract and Its Isolated Fraction D on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells. 61
31068381 2019
39
Survey of Reticuloendotheliosis Virus in Wild Turkeys (Meleagris gallopavo) in Texas, USA. 61
30557122 2019
40
Genetic characterization of reticuloendotheliosis virus in chickens in Thailand. 61
30668827 2019
41
Spotlight on avian pathology: fowlpox virus. 61
30507248 2019
42
Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes. 61
30871024 2019
43
Epidemiological investigation of the novel genotype avian hepatitis E virus and co-infected immunosuppressive viruses in farms with hepatic rupture haemorrhage syndrome, recently emerged in China. 61
30484967 2019
44
Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma. 61
30452715 2019
45
Multifunctional miR-155 Pathway in Avian Oncogenic Virus-Induced Neoplastic Diseases. 61
30871221 2019
46
Integrated Analysis of miRNA and mRNA Expression Profiles in Spleen of Specific Pathogen-Free Chicken Infected with Avian Reticuloendotheliosis Virus Strain SNV. 61
30818863 2019
47
Increased Horizontal Transmission of Recombinant Marek's Disease Virus Due to Reticuloendotheliosis Virus Long Terminal Repeat Is the Major Competitive Advantage of the Virus Being a Prevalent Strain. 61
31921027 2019
48
DETECTION OF LYMPHOPROLIFERATIVE DISEASE VIRUS IN CANADA IN A SURVEY FOR VIRUSES IN ONTARIO WILD TURKEYS ( MELEAGRIS GALLOPAVO). 61
30124393 2019
49
Assessment on reticuloendotheliosis virus infection in specific-pathogen-free chickens based on detection of yolk antibody. 61
31009463 2019
50
Detection of Fowlpox virus carrying distinct genome segments of Reticuloendotheliosis virus. 61
30359622 2019
Sources

Variations for Reticuloendotheliosis, X-Linked

About this section
Sources

Expression for Reticuloendotheliosis, X-Linked

About this section
Search GEO for disease gene expression data for Reticuloendotheliosis, X-Linked.
Sources

Pathways for Reticuloendotheliosis, X-Linked

About this section

Pathways related to Reticuloendotheliosis, X-Linked according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Ras signaling pathway 36
Show member pathways
 12.35 RELA REL
2
Downstream signaling events of B Cell Receptor (BCR) 65
Show member pathways
 12.34 RELA REL
3
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.33 RELA REL
4
NF-KappaB Family Pathway 63
Show member pathways
 12.32 RELA REL
5
4-1BB Pathway 63
Show member pathways
 12.29 RELA REL
6
Immune response NFAT in immune response 22
Show member pathways
 12.25 RELA REL
7
T cell receptor signaling pathway 36
Show member pathways
 12.23 RELA REL
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.22 RELA REL
9
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.21 RELA REL
10
NF-kappaB Signaling 4
12.19 RELA REL
11
VEGF Signaling 66
Show member pathways
 12.14 RELA REL
12
Prolactin Signaling Pathway 36 1
Show member pathways
 12.12 RELA REL
13
B Cell Receptor Signaling Pathway (sino) 66
Show member pathways
 12.1 RELA REL
14
B cell receptor signaling pathway (KEGG) 36
Show member pathways
 12.06 RELA REL
15
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.05 RELA REL
16
Development IGF-1 receptor signaling 22
Show member pathways
 12.04 RELA REL
17
IL-17 Family Signaling Pathways 64
Show member pathways
 11.99 RELA REL
18
Development A3 receptor signaling 22
Show member pathways
 11.98 RELA REL
19
Translation Non-genomic (rapid) action of Androgen Receptor 22
Show member pathways
 11.97 RELA REL
20
Viral carcinogenesis 36
11.95 RELA REL
21
IL-1 signaling pathway 1
Show member pathways
 11.95 RELA REL
22
Development EGFR signaling pathway 22
Show member pathways
 11.94 RELA REL
23
Transcriptional misregulation in cancer 36
11.92 RELA REL
24
Diseases associated with the TLR signaling cascade 65
Show member pathways
 11.91 RELA REL
25
C-type lectin receptor signaling pathway 36
Show member pathways
 11.86 RELA REL
26
Development NOTCH1-mediated pathway for NF-KB activity modulation 22
Show member pathways
 11.84 RELA REL
27
GDNF-Family Ligands and Receptor Interactions 63
Show member pathways
 11.83 RELA REL
28
Bacterial infections in CF airways 22
Show member pathways
 11.82 RELA REL
29
Development A2A receptor signaling 22
Show member pathways
 11.67 RELA REL
30
IL12-mediated signaling events 1
Show member pathways
 11.61 RELA REL
31
TGF-beta Signaling Pathways 64
11.53 RELA REL
32
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.5 RELA REL
33
Inhibitory action of Lipoxins on Superoxide production in neutrophils 22
Show member pathways
 11.49 RELA REL
34
Transcription_P53 signaling pathway 22
11.36 RELA REL
35
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.36 RELA REL
36
Development_TGF-beta receptor signaling 22
11.33 RELA REL
37
IL-2 Gene Expression in Activated and Quiescent T-Cells 63
Show member pathways
 11.26 RELA REL
38
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.26 RELA REL
39
Transcriptional Regulatory Network in Embryonic Stem Cell 63
11.21 RELA REL
40
Transcription_NF-kB signaling pathway 22
11.17 RELA REL
41
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.14 RELA REL
42
Cellular Transformation by HTLV1 63
Show member pathways
 11.08 RELA REL
43
Tacrolimus/Cyclosporine Pathway, Pharmacodynamics 60
10.97 RELA REL
44
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
10.9 RELA REL
45
Telomere Extension by Telomerase 63
Show member pathways
 10.83 RELA REL
46
Development_Glucocorticoid receptor signaling 22
10.77 RELA REL
47
Immune response_IL-6 signaling pathway 22
10.47 RELA REL
48
Atypical NF-kappaB pathway 1
9.77 RELA REL
Sources

GO Terms for Reticuloendotheliosis, X-Linked

About this section

Cellular components related to Reticuloendotheliosis, X-Linked according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 9.16 RELA REL
2 host cell nucleus GO:0042025 8.96 RELA REL
3 I-kappaB/NF-kappaB complex GO:0033256 8.62 RELA REL

Biological processes related to Reticuloendotheliosis, X-Linked according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.37 RELA REL
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.32 RELA REL
3 NIK/NF-kappaB signaling GO:0038061 9.26 RELA REL
4 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.16 RELA REL
5 response to cytokine GO:0034097 8.96 RELA REL
6 cellular response to stress GO:0033554 8.62 RELA REL

Molecular functions related to Reticuloendotheliosis, X-Linked according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.16 RELA REL
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.96 RELA REL
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.62 RELA REL
Sources

Sources for Reticuloendotheliosis, X-Linked

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....