MCID: RTC001
MIFTS: 34

Reticulohistiocytic Granuloma

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Reticulohistiocytic Granuloma

MalaCards integrated aliases for Reticulohistiocytic Granuloma:

Name: Reticulohistiocytic Granuloma 12 15 73
Reticulohistiocytoma 12 53
Solitary Reticulohistiocytosis 53
Solitary Reticulohistiocytoma 12
Solitary Histiocytoma 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4394
MeSH 44 D015616
NCIt 50 C3356
UMLS 73 C0035290

Summaries for Reticulohistiocytic Granuloma

NIH Rare Diseases : 53 Reticulohistiocytoma (RH) is a rare benign lesion of the soft tissue. It belongs to a group of disorders called non-Langerhans cell histiocytosis and is a type of reticulohistiocytosis, all of which are types of histiocytosis. Histiocytosis is a condition in which there is rapid production (proliferation) of histiocytes (immune cells) in the skin or soft tissues. The stimulus that causes the immune system to react in RH is currently not well understood. RH present as a yellow to reddish-brown smooth surfaced, firm nodule or lesion on the trunk and/or extremities of the body. Historically, RH has been found in young adults, with a slightly higher incidence in males. RH typically resolve spontaneously over a period of months to years, are not associated with systemic disease, and do not otherwise affect health. Treatment involves surgical removal of the lesion.

MalaCards based summary : Reticulohistiocytic Granuloma, also known as reticulohistiocytoma, is related to histiocytoma and histiocytosis. An important gene associated with Reticulohistiocytic Granuloma is LYZ (Lysozyme), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Affiliated tissues include skin and tongue, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Reticulohistiocytoma is a cutaneous condition characterized by a solitary, firm, dermal skin lesion of... more...

Related Diseases for Reticulohistiocytic Granuloma

Diseases related to Reticulohistiocytic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 31.0 CD163 PTPRC SERPINA3
2 histiocytosis 28.2 CD163 CD207 FSCN1 PTPRC SERPINA3 TNFRSF8
3 cavernous sinus meningioma 10.9 CD163 CD207
4 congenital granular cell tumor 10.9 LYZ SERPINA1
5 langerhans cell sarcoma 10.8 CD163 CD207
6 acinar cell cystadenocarcinoma 10.8 SERPINA1 SERPINA3
7 interdigitating dendritic cell sarcoma 10.8 CD163 PTPRC
8 cutaneous solitary mastocytoma 10.7 LYZ SERPINA1 SERPINA3
9 phacolytic glaucoma 10.7 CD68 SERPINA1
10 cutaneous fibrous histiocytoma 10.7 CD163 HAVCR1 SERPINA3
11 hodgkin's lymphoma, mixed cellularity 10.7 PTPRC UCHL1
12 histiocytic and dendritic cell cancer 10.7 CD163 CD207 PTPRC
13 central nervous system sarcoma 10.6 CD163 CD68 LYZ
14 petroclival meningioma 10.6 CD163 CD68
15 liver sarcoma 10.6 CD68 LYZ
16 fibrous histiocytoma 10.6 CD163 MITF SERPINA3
17 xanthogranulomatous pyelonephritis 10.6 CD68 LYZ SERPINA3
18 malignant fibroxanthoma 10.6 PTPRC SERPINA1 SERPINA3
19 parasitic ichthyosporea infectious disease 10.5 CD68 SERPINA1
20 malignant giant cell tumor of soft parts 10.5 CD68 LYZ PTPRC
21 inflammatory mfh 10.5 CD68 SERPINA1 SERPINA3
22 rhinosporidiosis 10.5 CD68 SERPINA1
23 brain sarcoma 10.5 CD163 CD68 PTPRC
24 alk+ histiocytosis 10.5 CD207 FSCN1
25 photokeratitis 10.5 CD163 CD68 PTPRC
26 dermis tumor 10.5 CD163 HAVCR1 LYZ SERPINA3
27 lymphoplasmacyte-rich meningioma 10.5 CD163 CD68 UCHL1
28 verruciform xanthoma of skin 10.5 CD68 S100A9
29 scrotal carcinoma 10.5 CD68 SERPINA3
30 granular cell tumor 10.4 CD68 SERPINA3 UCHL1
31 retinal hemangioblastoma 10.4 LYZ S100A9 SERPINA3
32 extraosseous osteosarcoma 10.4 CD34 PTPRC
33 retina lymphoma 10.4 CD34 CD68
34 diffuse cutaneous mastocytosis 10.4 CD34 PTPRC
35 in situ pulmonary adenocarcinoma 10.4 LYZ S100A9 SERPINA1
36 vulvar sarcoma 10.4 CD34 PTPRC
37 chronic monocytic leukemia 10.4 CD34 PTPRC
38 hemangioma of liver 10.3 CD34 CD68
39 rhinoscleroma 10.3 CD68 SERPINA1 SPN
40 breast angiosarcoma 10.3 CD34 MITF
41 melanotic neurilemmoma 10.3 CD34 CD68 LYZ
42 spleen cancer 10.2 CD163 CD34 CD68
43 juvenile xanthogranuloma 10.2 FSCN1 LYZ
44 gastric small cell carcinoma 10.2 PTPRC UCHL1
45 malignant histiocytosis 10.2 LYZ SERPINA3 TNFRSF8
46 erythema elevatum diutinum 10.2 CD34 S100A9
47 liver inflammatory pseudotumor 10.2 CD34 PTPRC UCHL1
48 mixed liposarcoma 10.2 CD34 CD68
49 lymphatic system cancer 10.2 LYZ PTPRC TNFRSF8
50 extracutaneous mastocytoma 10.2 CD34 CD68 PTPRC

Graphical network of the top 20 diseases related to Reticulohistiocytic Granuloma:



Diseases related to Reticulohistiocytic Granuloma

Symptoms & Phenotypes for Reticulohistiocytic Granuloma

MGI Mouse Phenotypes related to Reticulohistiocytic Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CD163 CD207 CD34 CD68 FUT4 LYZ
2 immune system MP:0005387 9.4 CD163 CD207 CD34 CD68 FSCN1 FUT4

Drugs & Therapeutics for Reticulohistiocytic Granuloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Rare Histiocytic Disorders Registry (IRHDR) Recruiting NCT02285582

Search NIH Clinical Center for Reticulohistiocytic Granuloma

Genetic Tests for Reticulohistiocytic Granuloma

Anatomical Context for Reticulohistiocytic Granuloma

MalaCards organs/tissues related to Reticulohistiocytic Granuloma:

41
Skin, Tongue

Publications for Reticulohistiocytic Granuloma

Articles related to Reticulohistiocytic Granuloma:

# Title Authors Year
1
Reticulohistiocytic granuloma of the tongue: a case report. ( 20830895 )
1993
2
Intradermal Spitz nevus differentiated from reticulohistiocytic granuloma by immunoreactivity to S-100 protein. ( 2277146 )
1990
3
Solitary reticulohistiocytic granuloma. ( 13536925 )
1958
4
Reticulohistiocytic granuloma (reticulohistiocytoma) of the skin. ( 13197332 )
1954

Variations for Reticulohistiocytic Granuloma

Expression for Reticulohistiocytic Granuloma

Search GEO for disease gene expression data for Reticulohistiocytic Granuloma.

Pathways for Reticulohistiocytic Granuloma

GO Terms for Reticulohistiocytic Granuloma

Cellular components related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 CD163 CD34 CEACAM6 PTPRC RHCE SPN
2 extracellular exosome GO:0070062 9.32 EPHX2 FSCN1 LYZ PTPRC S100A9 SERPINA1

Biological processes related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 CD163 EPHX2 LYZ S100A9 SERPINA3 TNFRSF8
2 acute-phase response GO:0006953 9.33 CD163 SERPINA1 SERPINA3
3 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.26 SPN TNFRSF8
4 neutrophil degranulation GO:0043312 9.17 CD68 CEACAM6 LYZ PTPRC S100A9 SERPINA1

Sources for Reticulohistiocytic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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