MCID: RTC001
MIFTS: 38

Reticulohistiocytic Granuloma

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Reticulohistiocytic Granuloma

MalaCards integrated aliases for Reticulohistiocytic Granuloma:

Name: Reticulohistiocytic Granuloma 12 15 73
Reticulohistiocytoma 12 53
Solitary Reticulohistiocytosis 53
Solitary Reticulohistiocytoma 12
Solitary Histiocytoma 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4394
MeSH 44 D015616
NCIt 50 C3356
SNOMED-CT 68 15960008
UMLS 73 C0035290

Summaries for Reticulohistiocytic Granuloma

NIH Rare Diseases : 53 Reticulohistiocytoma (RH) is a rare benign lesion of the soft tissue. It belongs to a group of disorders called non-Langerhans cell histiocytosis and is a type of reticulohistiocytosis, all of which are types of histiocytosis. Histiocytosis is a condition in which there is rapid production (proliferation) of histiocytes (immune cells) in the skin or soft tissues. The stimulus that causes the immune system to react in RH is currently not well understood. RH present as a yellow to reddish-brown smooth surfaced, firm nodule or lesion on the trunk and/or extremities of the body. Historically, RH has been found in young adults, with a slightly higher incidence in males. RH typically resolve spontaneously over a period of months to years, are not associated with systemic disease, and do not otherwise affect health. Treatment involves surgical removal of the lesion.

MalaCards based summary : Reticulohistiocytic Granuloma, also known as reticulohistiocytoma, is related to histiocytoma and histiocytosis. An important gene associated with Reticulohistiocytic Granuloma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Affiliated tissues include skin, b cells and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Reticulohistiocytoma is a cutaneous condition characterized by a solitary, firm, dermal skin lesion of... more...

Related Diseases for Reticulohistiocytic Granuloma

Diseases related to Reticulohistiocytic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 30.5 CD163 MITF PTPRC SERPINA3
2 histiocytosis 29.7 CD163 CD207 PTPRC SERPINA3 TNFRSF8
3 cavernous sinus meningioma 10.3 CD163 CD207
4 congenital granular cell tumor 10.3 LYZ SERPINA1
5 acinar cell cystadenocarcinoma 10.3 SERPINA1 SERPINA3
6 langerhans cell sarcoma 10.3 CD163 CD207
7 interdigitating dendritic cell sarcoma 10.3 CD163 PTPRC
8 cardiomyopathy, infantile histiocytoid 10.2 CD68 LYZ
9 non-langerhans-cell histiocytosis 10.2 CD163 CD207 LYZ
10 multicentric reticulohistiocytosis 10.2
11 phacolytic glaucoma 10.2 CD68 SERPINA1
12 cutaneous solitary mastocytoma 10.2 LYZ SERPINA1 SERPINA3
13 hodgkin's lymphoma, mixed cellularity 10.2 PTPRC UCHL1
14 parasitic ichthyosporea infectious disease 10.2 CD68 SERPINA1
15 brain sarcoma 10.2 CD68 PTPRC
16 rhinosporidiosis 10.2 CD68 SERPINA1
17 petroclival meningioma 10.2 CD163 CD68
18 central nervous system sarcoma 10.2 CD163 CD68 LYZ
19 scrotal carcinoma 10.2 CD68 SERPINA3
20 liver sarcoma 10.2 CD68 LYZ
21 fibrous histiocytoma 10.2 CD163 MITF SERPINA3
22 xanthogranulomatous pyelonephritis 10.2 CD68 LYZ SERPINA3
23 inflammatory mfh 10.2 CD68 SERPINA1 SERPINA3
24 malignant giant cell tumor of soft parts 10.2 CD68 LYZ PTPRC
25 alk+ histiocytosis 10.2 CD207 FSCN1
26 trigeminal nerve neoplasm 10.2 CD68 LYZ PTPRC
27 neurilemmoma of the fifth cranial nerve 10.2 CD68 LYZ PTPRC
28 photokeratitis 10.2 CD163 CD68 PTPRC
29 lymphoplasmacyte-rich meningioma 10.2 CD163 CD68 UCHL1
30 dermis tumor 10.1 CD163 HAVCR1 LYZ SERPINA3
31 histiocytic and dendritic cell cancer 10.1 CD163 CD207 LYZ PTPRC
32 spitz nevus 10.1
33 granular cell tumor 10.1 CD68 SERPINA3 UCHL1
34 retinal hemangioblastoma 10.1 LYZ S100A9 SERPINA3
35 retina lymphoma 10.1 CD34 CD68
36 gastric small cell carcinoma 10.1 PTPRC UCHL1
37 malignant fibroxanthoma 10.1 LYZ PTPRC SERPINA1 SERPINA3
38 vulvar sarcoma 10.1 CD34 PTPRC
39 in situ pulmonary adenocarcinoma 10.1 LYZ S100A9 SERPINA1
40 diffuse meningeal melanocytosis 10.1 CD68 S100A9
41 chronic monocytic leukemia 10.1 CD34 PTPRC
42 cutaneous fibrous histiocytoma 10.1 HAVCR1 SERPINA3
43 rhinoscleroma 10.1 CD68 SERPINA1 SPN
44 hemangioma of liver 10.1 CD34 CD68
45 juvenile xanthogranuloma 10.1 FSCN1 LYZ
46 ganglioneuroma 10.1
47 breast angiosarcoma 10.1 CD34 MITF
48 spleen cancer 10.1 CD163 CD34 CD68
49 malignant histiocytosis 10.1 LYZ SERPINA3 TNFRSF8
50 mixed liposarcoma 10.1 CD34 CD68

Graphical network of the top 20 diseases related to Reticulohistiocytic Granuloma:



Diseases related to Reticulohistiocytic Granuloma

Symptoms & Phenotypes for Reticulohistiocytic Granuloma

GenomeRNAi Phenotypes related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.07 PTPRC
2 Decreased viability GR00240-S-1 10.07 CEACAM6
3 Decreased viability GR00381-A-1 10.07 CD163 RHCE
4 Decreased viability GR00381-A-2 10.07 CD163
5 Decreased viability GR00381-A-3 10.07 CD163 RHCE
6 Decreased viability GR00402-S-2 10.07 CD163 CD207 CD34 CD68 CEACAM6 EPHX2
7 no effect GR00402-S-1 9.6 CD163 CD207 CD34 CD68 CEACAM6 EPHX2

MGI Mouse Phenotypes related to Reticulohistiocytic Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CD163 CD207 CD34 CD68 FUT4 LYZ
2 immune system MP:0005387 9.4 CD163 CD207 CD34 CD68 FSCN1 FUT4

Drugs & Therapeutics for Reticulohistiocytic Granuloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Rare Histiocytic Disorders Registry (IRHDR) Recruiting NCT02285582

Search NIH Clinical Center for Reticulohistiocytic Granuloma

Genetic Tests for Reticulohistiocytic Granuloma

Anatomical Context for Reticulohistiocytic Granuloma

MalaCards organs/tissues related to Reticulohistiocytic Granuloma:

41
Skin, B Cells, Brain, Liver, Bone, Spleen, Thymus

Publications for Reticulohistiocytic Granuloma

Articles related to Reticulohistiocytic Granuloma:

(show all 41)
# Title Authors Year
1
Crown vessels and follicular white dot: New dermoscopic findings in a case of solitary reticulohistiocytoma. ( 29447684 )
2018
2
Dermoscopy of solitary cutaneous reticulohistiocytoma. ( 29767484 )
2018
3
Eruption of solitary reticulohistiocytoma after intense pulsed light burn. ( 30456281 )
2018
4
Solitary reticulohistiocytoma with arborizing vessels: A new mimicker of basal cell carcinoma. ( 26702812 )
2016
5
Multiple Cutaneous Reticulohistiocytoma. ( 26955136 )
2016
6
Reticulohistiocytoma of the orbit. ( 24807799 )
2015
7
Paediatric cutaneous reticulohistiocytoma: a diagnostic challenge on fine needle aspiration. ( 25363204 )
2015
8
A plaque-type solitary reticulohistiocytoma in a two-year-old boy. ( 25759651 )
2015
9
Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features. ( 26081827 )
2015
10
Multiple cutaneous reticulohistiocytoma in middle aged female. ( 24616864 )
2014
11
Adult-onset reticulohistiocytoma presenting as a solitary asymptomatic red knee nodule: report and review of clinical presentations and immunohistochemistry staining features of reticulohistiocytosis. ( 24656263 )
2014
12
Granulomatous reaction after BCG vaccination histologically mimicking reticulohistiocytoma. ( 24001994 )
2013
13
Xanthomatous papule in a child. Solitary reticulohistiocytoma (SRH). ( 20500182 )
2010
14
Solitary cutaneous histiocytosis with granular cell changes: a morphological variant of reticulohistiocytoma? ( 19615000 )
2010
15
Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. ( 16625100 )
2006
16
Reticulohistiocytoma of the external auditory canal. ( 14597378 )
2003
17
Reticulohistiocytic granuloma of the tongue: a case report. ( 20830895 )
1993
18
Solitary reticulohistiocytosis (reticulohistiocytoma) of the skin in children: report of two cases. ( 1575538 )
1992
19
Reticulohistiocytoma of the dorsum (Crosti's disease) and other B-cell lymphomas. ( 1871453 )
1991
20
Intradermal Spitz nevus differentiated from reticulohistiocytic granuloma by immunoreactivity to S-100 protein. ( 2277146 )
1990
21
Reticulohistiocytoma of the limbus and cornea. A clinicopathologic study of two cases. ( 2205816 )
1990
22
Reticulohistiocytoma cutis--review of 15 cases and an association with systemic vasculitis in two cases. ( 2311271 )
1990
23
Solitary papule on the forearm. Solitary reticulohistiocytoma. ( 2334190 )
1990
24
Reticulohistiocytoma of the dorsum. ( 3049688 )
1988
25
Congenital self-healing reticulohistiocytoma. A clinical, histological and ultrastructural study. ( 3984719 )
1985
26
Reticulohistiocytoma. ( 7250446 )
1980
27
Electron microscopic study of reticulohistiocytoma. An unusual case of congenital, self-healing reticulohistiocytosis. ( 4346639 )
1973
28
A relatively benign reticulosis: Crosti's "reticulohistiocytoma of the back". ( 4694179 )
1973
29
Reticulohistiocytoma cutis. ( 4319796 )
1970
30
Giant cell reticulohistiocytoma associated with cancer. ( 5214354 )
1965
31
1. MULTIPLE BENIGN HISTIOCYTOMA. 2. RETICULOHISTIOCYTOMA. ( 14122112 )
1964
32
PSEUDOSARCOMATOUS RETICULOHISTIOCYTOMA; A REPORT OF FOUR CASES. ( 14170607 )
1964
33
Lipoid dermato-arthritis. Reticulohistiocytoma of the skin and joints. ( 13792384 )
1960
34
Reticulohistiocytoma: a rare dermatologic disease with roentgen manifestations. ( 14444041 )
1960
35
Solitary reticulohistiocytic granuloma. ( 13536925 )
1958
36
Reticulohistiocytoma (reticulo-histiocytic granuloma). ( 13486934 )
1958
37
Reticulohistiocytoma (type Caro/Senear). ( 13567686 )
1958
38
The so-called reticulohistiocytoma of the skin; a comparison of two distinct types. ( 13239964 )
1955
39
Reticulohistiocytic granuloma (reticulohistiocytoma) of the skin. ( 13197332 )
1954
40
Reticulohistiocytoma of the skin. ( 14922957 )
1952
41
Reticulohistiocytoma ("ganglioneuroma") of the skin. ( 24538413 )
1950

Variations for Reticulohistiocytic Granuloma

Expression for Reticulohistiocytic Granuloma

Search GEO for disease gene expression data for Reticulohistiocytic Granuloma.

Pathways for Reticulohistiocytic Granuloma

GO Terms for Reticulohistiocytic Granuloma

Cellular components related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 CD34 CEACAM6 FUT4 PTPRC SPN
2 extracellular exosome GO:0070062 9.28 EPHX2 FSCN1 LYZ PTPRC S100A9 SERPINA1
3 cell periphery GO:0071944 9.13 CD34 FUT4 PTPRC

Biological processes related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.55 CD163 EPHX2 LYZ S100A9 SERPINA3
2 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.26 SPN TNFRSF8
3 neutrophil degranulation GO:0043312 9.17 CD68 CEACAM6 LYZ PTPRC S100A9 SERPINA1
4 acute-phase response GO:0006953 9.13 CD163 SERPINA1 SERPINA3

Sources for Reticulohistiocytic Granuloma

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
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35 ICD9CM
36 IUPHAR
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45 MESH via Orphanet
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49 NCI
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51 NDF-RT
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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