MCID: RTC001
MIFTS: 31

Reticulohistiocytic Granuloma

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Reticulohistiocytic Granuloma

MalaCards integrated aliases for Reticulohistiocytic Granuloma:

Name: Reticulohistiocytic Granuloma 12 15 70
Reticulohistiocytoma 12 20
Solitary Reticulohistiocytosis 20
Solitary Reticulohistiocytoma 12
Solitary Histiocytoma 20

Classifications:



External Ids:

Disease Ontology 12 DOID:4394
MeSH 44 D015616
NCIt 50 C3356
SNOMED-CT 67 15960008
UMLS 70 C0035290

Summaries for Reticulohistiocytic Granuloma

GARD : 20 Reticulohistiocytoma (RH) is a rare benign lesion of the soft tissue. It belongs to a group of disorders called non-Langerhans cell histiocytosis and is a type of reticulohistiocytosis, all of which are types of histiocytosis. Histiocytosis is a condition in which there is rapid production (proliferation) of histiocytes (immune cells ) in the skin or soft tissues. The stimulus that causes the immune system to react in RH is currently not well understood. RH present as a yellow to reddish-brown smooth surfaced, firm nodule or lesion on the trunk and/or extremities of the body. Historically, RH has been found in young adults, with a slightly higher incidence in males. RH typically resolve spontaneously over a period of months to years, are not associated with systemic disease, and do not otherwise affect health. Treatment involves surgical removal of the lesion.

MalaCards based summary : Reticulohistiocytic Granuloma, also known as reticulohistiocytoma, is related to multicentric reticulohistiocytosis and cutaneous fibrous histiocytoma. An important gene associated with Reticulohistiocytic Granuloma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Tight junction. Affiliated tissues include skin, ovary and lymph node.

Wikipedia : 73 Reticulohistiocytoma is a cutaneous condition characterized by a solitary, firm, dermal skin lesion of... more...

Related Diseases for Reticulohistiocytic Granuloma

Diseases related to Reticulohistiocytic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 multicentric reticulohistiocytosis 30.0 SERPINA3 CD68 CD1E
2 cutaneous fibrous histiocytoma 29.9 SERPINA3 CD68
3 histiocytic sarcoma 29.9 CD68 CD163
4 granular cell tumor 29.9 SERPINA3 CD68
5 histiocytosis 29.7 SERPINA3 CD1C CD1A CD163
6 juvenile xanthogranuloma 29.7 SERPINA3 CD1E CD1A
7 langerhans cell histiocytosis 29.3 CD68 CD1C CD1A CD163
8 skin disease 29.3 SERPINA3 CD1C CD1A CD163
9 erdheim-chester disease 28.1 SERPINA3 CD1E CD1D CD1C CD1B CD1A
10 adult xanthogranuloma 27.7 SERPINA3 CD68 CD1E CD1D CD1C CD1B
11 non-langerhans-cell histiocytosis 27.6 SERPINA3 CD68 CD1E CD1D CD1C CD1B
12 congenital epulis 10.2 SERPINA3 CD68
13 epulis 10.2 SERPINA3 CD68
14 verruciform xanthoma of skin 10.2 SERPINA3 CD68
15 proliferative fasciitis 10.2 SERPINA3 CD68
16 malignant inflammatory fibrous histiocytoma 10.2 SERPINA3 CD68
17 pancreas sarcoma 10.2 SERPINA3 CD68
18 xanthogranulomatous pyelonephritis 10.2 SERPINA3 CD68
19 sarcomatoid squamous cell skin carcinoma 10.2 SERPINA3 CD68
20 malignant granular cell myoblastoma 10.2 SERPINA3 CD68
21 liver sarcoma 10.2 SERPINA3 CD68
22 pleomorphic lipoma 10.2 SERPINA3 CD68
23 xanthogranulomatous cholecystitis 10.2 SERPINA3 CD68
24 malignant spindle cell melanoma 10.2 SERPINA3 CD68
25 giant cell reparative granuloma 10.2 SERPINA3 CD68
26 bladder sarcoma 10.2 SERPINA3 CD68
27 fibroma 10.2 SERPINA3 CD68
28 central nervous system vasculitis 10.2 SERPINA3 CD68
29 granulomatous orchitis 10.2 CD68 CD1E
30 bone benign neoplasm 10.2 SERPINA3 CD68
31 myofibroma 10.2 SERPINA3 CD1A
32 pigmented villonodular synovitis 10.2 SERPINA3 CD68
33 dendritic cell tumor 10.1 CD68 CD1A
34 bronchopneumonia 10.1 SERPINA3 CD68
35 predominantly cortical thymoma 10.1 CD1E CD1A
36 pseudosarcomatous fibromatosis 10.1 SERPINA3 CD68
37 tolosa-hunt syndrome 10.1 CD1E CD1A
38 bone giant cell tumor 10.1 SERPINA3 CD68
39 dendritic cell thymoma 10.1 CD1E CD1A
40 multifocal motor neuropathy 10.1 CD1E CD1A
41 oral hairy leukoplakia 10.1 CD1E CD1A
42 pityriasis rosea 10.1 CD1E CD1A
43 mesenchymal cell neoplasm 10.1 SERPINA3 CD68
44 kimura disease 10.1 CD1E CD1A
45 reticulosarcoma 10.1 SERPINA3 CD68
46 esophageal tuberculosis 10.1 CD68 CD163
47 hypersensitivity reaction type iv disease 10.1 SERPINA3 CD68
48 ischemic fasciitis 10.1 CD68 CD163
49 vascular cancer 10.1 SERPINA3 CD68
50 mite infestation 10.1 CD1B CD1A

Graphical network of the top 20 diseases related to Reticulohistiocytic Granuloma:



Diseases related to Reticulohistiocytic Granuloma

Symptoms & Phenotypes for Reticulohistiocytic Granuloma

Drugs & Therapeutics for Reticulohistiocytic Granuloma

Search Clinical Trials , NIH Clinical Center for Reticulohistiocytic Granuloma

Genetic Tests for Reticulohistiocytic Granuloma

Anatomical Context for Reticulohistiocytic Granuloma

MalaCards organs/tissues related to Reticulohistiocytic Granuloma:

40
Skin, Ovary, Lymph Node, Spleen, Thyroid, Endothelial, Tongue

Publications for Reticulohistiocytic Granuloma

Articles related to Reticulohistiocytic Granuloma:

(show top 50) (show all 122)
# Title Authors PMID Year
1
Solitary reticulohistiocytoma: a rare ocular surface mass. 61
32890466 2021
2
Reticulohistiocytoma (solitary epithelioid histiocytoma) with mutations in RAF1 and TSC2. 61
32342514 2020
3
Reticulohistiocytoses: a revision of the full spectrum. 61
31955466 2020
4
Dermoscopic features of a case of solitary reticulohistiocytoma. 61
32445312 2020
5
BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease. 61
31639332 2019
6
Langerhans cell histiocytosis and multiple reticulohistiocytomas in a patient with TAR syndrome: An association not previously described. 61
31006900 2019
7
Eruption of solitary reticulohistiocytoma after intense pulsed light burn. 61
30456281 2018
8
Dermoscopy of solitary cutaneous reticulohistiocytoma. 61
29767484 2018
9
Case for diagnosis. Solitary violaceous nodule on the toe. 61
33288060 2018
10
Case for diagnosis. Solitary violaceous nodule on the toe. 61
30066776 2018
11
Rare diseases of bone: Erdheim-Chester and Rosai-Dorfman non-Langerhans cell histiocytoses. 61
30034819 2018
12
Crown vessels and follicular white dot: New dermoscopic findings in a case of solitary reticulohistiocytoma. 61
29447684 2018
13
Hemosiderotic Juvenile Xanthogranuloma. 61
28398921 2017
14
Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions. 61
27152444 2016
15
Multiple Cutaneous Reticulohistiocytoma. 61
26955136 2016
16
Solitary reticulohistiocytoma with arborizing vessels: A new mimicker of basal cell carcinoma. 61
26702812 2016
17
Paediatric cutaneous reticulohistiocytoma: a diagnostic challenge on fine needle aspiration. 61
25363204 2015
18
Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features. 61
26081827 2015
19
Reticulohistiocytoma of the orbit. 61
24807799 2015
20
A plaque-type solitary reticulohistiocytoma in a two-year-old boy. 61
25759651 2015
21
Adult-onset reticulohistiocytoma presenting as a solitary asymptomatic red knee nodule: report and review of clinical presentations and immunohistochemistry staining features of reticulohistiocytosis. 61
24656263 2014
22
Multiple cutaneous reticulohistiocytoma in middle aged female. 61
24616864 2014
23
Soft tissue giant cell tumour of low malignant potential: a rare tumour at a rare site. 61
24551690 2013
24
Granulomatous reaction after BCG vaccination histologically mimicking reticulohistiocytoma. 61
24001994 2013
25
Progressive nodular histiocytosis with normal karyotypic analysis. 61
24011326 2013
26
Angiosarcoma of the nasal septum mimicking reticulohistiocytoma. 61
23714990 2013
27
Nonepithelial skin tumors with multinucleated giant cells. 61
23327730 2013
28
Solitary epithelioid histiocytoma (reticulohistiocytoma) of the glans penis. 61
22777481 2012
29
Solitary epithelioid histiocytoma (reticulohistiocytoma) of the eyelid. 61
22084226 2011
30
Selected Lesions Featuring Giant Cells. 61
26837653 2011
31
Xanthomatous papule in a child. Solitary reticulohistiocytoma (SRH). 61
20500182 2010
32
Solitary cutaneous histiocytosis with granular cell changes: a morphological variant of reticulohistiocytoma? 61
19615000 2010
33
[Single reticulohistiocytoma mimicking a keratoacanthoma]. 61
19091231 2008
34
Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. 61
17023812 2006
35
Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma. 61
16938667 2006
36
Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. 61
16625100 2006
37
[Multifocal adult rhabdomyoma of the neck: a rare entity]. 61
16521457 2005
38
Multiple cutaneous reticulohistiocytomas in a patient with rheumatoid arthritis. 61
15530301 2004
39
Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation. 61
15073606 2004
40
[Reticulohistiocytoma. Treatment with pulsed-dye laser]. 61
15138655 2004
41
Reticulohistiocytoma of the external auditory canal. 61
14597378 2003
42
Recurrent solitary reticulohistiocytoma of the eyelid. 61
12644769 2003
43
Fascin and the differential diagnosis of childhood histiocytic lesions. 61
10463281 1998
44
Unusual expression of S-100 protein in histiocytic neoplasms. 61
9550310 1998
45
Non-Langerhans cell histiocytoses. A new unifying concept. 61
8902096 1996
46
Reticulohistiocytoma involving the skin, subcutaneous tissue and a regional lymph node. 61
8870011 1996
47
Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study. 61
7669644 1995
48
Solitary reticulohistiocytoma in pregnancy: immunohistochemical and ultrastructural study of a case with unusual immunophenotype. 61
7560354 1995
49
Reticulohistiocytoma and multicentric reticulohistiocytosis. Histopathologic and immunophenotypic distinct entities. 61
7864294 1994
50
Cowden's disease: report of the first case in a Chinese. 61
8064004 1994

Variations for Reticulohistiocytic Granuloma

Expression for Reticulohistiocytic Granuloma

Search GEO for disease gene expression data for Reticulohistiocytic Granuloma.

Pathways for Reticulohistiocytic Granuloma

GO Terms for Reticulohistiocytic Granuloma

Cellular components related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.98 CD68 CD1E CD1D CD1C CD1B CD1A
2 extracellular space GO:0005615 9.8 SERPINA3 CD1E CD1D CD1C CD1B CD1A
3 integral component of plasma membrane GO:0005887 9.77 CD1E CD1D CD1C CD1A CD163
4 lysosome GO:0005764 9.65 CD68 CD1E CD1D CD1C CD1B
5 endosome GO:0005768 9.63 CD68 CD1E CD1D CD1C CD1B CD1A
6 lysosomal membrane GO:0005765 9.58 CD68 CD1D CD1B
7 endosome membrane GO:0010008 9.35 CD68 CD1D CD1C CD1B CD1A
8 external side of plasma membrane GO:0009897 9.1 CD1E CD1D CD1C CD1B CD1A CD163

Biological processes related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD1E CD1D CD1C CD1B CD1A
2 adaptive immune response GO:0002250 9.71 CD1E CD1C CD1B CD1A
3 immune response GO:0006955 9.65 CD1E CD1D CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.62 CD1D CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 acute-phase response GO:0006953 9.43 SERPINA3 CD163
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Reticulohistiocytic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Reticulohistiocytic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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