MCID: RTC005
MIFTS: 47

Reticulosarcoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Reticulosarcoma

MalaCards integrated aliases for Reticulosarcoma:

Name: Reticulosarcoma 12 15 70
Diffuse Large B-Cell Lymphoma 70
Histiocytic Lymphoma 12
Large-Cell Lymphomas 12
Lymphoma, Large-Cell 73
Histiocytic Sarcoma 70
Lymphoma Large Cell 54

Classifications:



External Ids:

Disease Ontology 12 DOID:8538
ICD9CM 34 200.0
MeSH 44 D008228
NCIt 50 C27824
SNOMED-CT 67 154579006
UMLS 70 C0024302 C0079744 C0334663

Summaries for Reticulosarcoma

MalaCards based summary : Reticulosarcoma, also known as diffuse large b-cell lymphoma, is related to reticulum cell sarcoma and langerhans cell histiocytosis. An important gene associated with Reticulosarcoma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vindesine and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include t cells, spleen and thyroid, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 73 Anaplastic large-cell lymphoma (ALCL) is a form of cancer. It is a type of non-Hodgkin lymphoma... more...

Related Diseases for Reticulosarcoma

Diseases related to Reticulosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 32.4 TNFRSF8 PTPRC MUC1
2 langerhans cell histiocytosis 32.0 PTPRC FSCN1 CD68
3 lymphosarcoma 31.1 TNFRSF8 PTPRC BCL6 BCL2
4 fibrosarcoma of bone 31.0 TNFRSF8 SERPINA3 CD68
5 lymphomatoid papulosis 30.8 TNFRSF8 TIA1 NPM1 GZMB ALK
6 alk-positive anaplastic large cell lymphoma 30.6 TNFRSF8 NPM1 ALK
7 mycosis fungoides 30.5 TNFRSF8 TIA1 GZMB ALK
8 mesenchymal cell neoplasm 30.5 SERPINA3 NPM1 CD68 ALK
9 histiocytic sarcoma 30.4 CD68 BCL2
10 anaplastic large cell lymphoma 30.4 TNFRSF8 TIA1 PTPRC PAX5 NPM1 MUC1
11 spindle cell sarcoma 30.4 SERPINA3 MUC1 CDKN1B
12 peripheral t-cell lymphoma 30.4 TNFRSF8 TIA1 PTPRC GZMB BCL6 ALK
13 hodgkin's lymphoma, lymphocytic-histiocytic predominance 30.4 TNFRSF8 PTPRC BCL6
14 mediastinal cancer 30.3 TNFRSF8 PTPRC PAX5
15 lymphoproliferative syndrome 30.3 TNFRSF8 TIA1 PTPRC BCL6 ALK
16 t-cell lymphoma, subcutaneous panniculitis-like 30.3 TRB TNFRSF8 TIA1 GZMB ALK
17 lung lymphoma 30.2 TNFRSF8 PAX5 BCL6
18 central nervous system lymphoma 30.2 PAX5 CD68 BCL6
19 histiocytosis 30.2 TNFRSF8 SERPINA3 PTPRC ALK
20 fibrous histiocytoma 30.2 SERPINA3 CD68 ALK
21 angioimmunoblastic t-cell lymphoma 30.2 TNFRSF8 TIA1 GZMB BCL6
22 plasmablastic lymphoma 30.1 PTPRC MUC1 BCL6
23 gastrointestinal lymphoma 30.1 TNFRSF8 TIA1 SERPINA3 BCL6
24 pleomorphic lipoma 30.1 SERPINA3 CD68
25 breast implant-associated anaplastic large cell lymphoma 30.1 TNFRSF8 ALK
26 immune deficiency disease 30.0 TNFRSF8 SERPINA3 PTPRC BCL6 B2M
27 small cell carcinoma 30.0 PTPRC MUC1 ALK
28 primary cutaneous anaplastic large cell lymphoma 30.0 TIA1 PTPRC NPM1 MUC1 GZMB ALK
29 composite lymphoma 29.9 TNFRSF8 TIA1 PAX5 GZMB BCL6
30 lymphoblastic lymphoma 29.9 TRB TNFRSF8 PTPRC PAX5 BCL6
31 diffuse large b-cell lymphoma 29.9 TNFRSF8 PTPRC PAX5 CCND3 BCL6 BCL2
32 peripheral nervous system disease 29.8 SERPINA3 PTPRC CD68 CASP3 B2M ALK
33 myeloid sarcoma 29.8 PTPRC PAX5 NPM1 CD68 ANPEP
34 malignant fibrous histiocytoma 29.8 SERPINA3 PTPRC MUC1 CD68
35 marginal zone b-cell lymphoma 29.8 TNFRSF8 PAX5 BCL6 BCL2
36 lymphoma, mucosa-associated lymphoid type 29.8 TNFRSF8 PTPRC PAX5 BCL6 BCL2 B2M
37 lymphoma, hodgkin, classic 29.7 TNFRSF8 TIA1 PTPRC PAX5 GZMB FSCN1
38 myeloma, multiple 29.7 PTPRC CCND3 CASP3 BCL6 B2M
39 b-lymphoblastic leukemia/lymphoma 29.7 PTPRC PAX5 PARP1 ANPEP ALK
40 burkitt lymphoma 29.7 TNFRSF8 PAX5 PARP1 CCND3 CASP3 BCL6
41 leukemia, acute lymphoblastic 29.5 TNFRSF8 PTPRC PAX5 CCND3 CASP3 BCL6
42 t-cell lymphoblastic leukemia/lymphoma 29.5 TNFRSF8 PTPRC CCND3 CASP3 BCL2
43 rhabdomyosarcoma 29.4 PTPRC PAX5 CDKN1B CASP3 ALK
44 leukemia, chronic lymphocytic 28.9 TNFRSF8 PTPRC PAX5 CCND3 CASP3 BCL6
45 b-cell lymphoma 28.9 TNFRSF8 TIA1 PTPRC PAX5 NPM1 CDKN1B
46 acute promyelocytic leukemia 28.8 PTPRC PARP1 NPM1 CDKN1B CASP3 BCL6
47 lymphoma, non-hodgkin, familial 28.5 TNFRSF8 SERPINA3 PTPRC PAX5 NPM1 GZMB
48 mantle cell lymphoma 28.5 PTPRC PAX5 PARP1 CDKN1B CCND3 CASP3
49 lymphoma 28.3 TNFRSF8 TIA1 PTPRC PAX5 NPM1 GZMB
50 lymphoma, large-cell, immunoblastic 11.5

Graphical network of the top 20 diseases related to Reticulosarcoma:



Diseases related to Reticulosarcoma

Symptoms & Phenotypes for Reticulosarcoma

MGI Mouse Phenotypes related to Reticulosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 ALK B2M BCL2 BCL6 CASP3 CCND3
2 hematopoietic system MP:0005397 10.13 ANPEP B2M BCL2 BCL6 CASP3 CCND3
3 endocrine/exocrine gland MP:0005379 10.07 ALK ANPEP B2M BCL2 BCL6 CASP3
4 immune system MP:0005387 10.03 ANPEP B2M BCL2 BCL6 CASP3 CCND3
5 integument MP:0010771 9.73 ALK ANPEP B2M BCL2 BCL6 CASP3
6 neoplasm MP:0002006 9.23 ALK B2M BCL2 CCND3 CDKN1B NPM1

Drugs & Therapeutics for Reticulosarcoma

Drugs for Reticulosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 349)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vindesine Approved, Investigational Phase 4 59917-39-4, 53643-48-4 40839
2
Epirubicin Approved Phase 4 56420-45-2 41867
3
Pirarubicin Investigational Phase 4 72496-41-4
4
Thalidomide Approved, Investigational, Withdrawn Phase 3 50-35-1 5426
5
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
6
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
7
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
8
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
9
Iodine Approved, Investigational Phase 3 7553-56-2 807
10
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
11
Vinblastine Approved Phase 3 865-21-4 241903 13342
12
Bexarotene Approved, Investigational Phase 3 153559-49-0 82146
13
leucovorin Approved Phase 3 58-05-9 6006
14
Mercaptopurine Approved Phase 3 50-44-2 667490
15
Pixantrone Approved, Investigational Phase 3 144510-96-3
16
Darbepoetin alfa Approved, Investigational Phase 3 209810-58-2, 11096-26-7
17
Everolimus Approved Phase 3 159351-69-6 6442177 70789204
18
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
19
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
20
Lenograstim Approved, Investigational Phase 3 135968-09-1
21
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
22
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
23
Gemcitabine Approved Phase 3 95058-81-4 60750
24
inotuzumab ozogamicin Approved, Investigational Phase 3 635715-01-4
25
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
26
Carmustine Approved, Investigational Phase 3 154-93-8 2578
27
Melphalan Approved Phase 3 148-82-3 4053 460612
28
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
29
Bevacizumab Approved, Investigational Phase 3 216974-75-3
30
Azacitidine Approved, Investigational Phase 3 320-67-2 9444
31
Obinutuzumab Approved, Investigational Phase 3 949142-50-1
32
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
33
Phenylalanine Approved, Investigational, Nutraceutical Phase 3 63-91-2 6140
34
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
35
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
36
Cadexomer iodine Experimental Phase 3 94820-09-4
37
Buformin Investigational, Withdrawn Phase 2, Phase 3 692-13-7
38
Molgramostim Investigational Phase 3 99283-10-0
39 Reverse Transcriptase Inhibitors Phase 2, Phase 3
40 Antimetabolites Phase 3
41 Trace Elements Phase 3
42 Nutrients Phase 3
43 Micronutrients Phase 3
44 Iodine-131 anti-B1 antibody Phase 3
45 Vitamin B9 Phase 3
46 Vitamin B Complex Phase 3
47 Folate Phase 3
48 Dermatologic Agents Phase 3
49 Interleukin-2 Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show top 50) (show all 883)
# Name Status NCT ID Phase Drugs
1 Single-arm, Multi-center Clinical Study of Crizotinib Combined With Etoposide Capsule Followed by Auto-HSCT for Relapsed and Refractory Anaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma (ALCL) Unknown status NCT03707847 Phase 4 Crizotinib;Etoposide Capsule
2 An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma Unknown status NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
3 A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma Unknown status NCT03579082 Phase 4 Decitabine
4 Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma Unknown status NCT03513601 Phase 4 (R)-CHOP regimen;(R)-CVP regimen
5 A Randomized, Controlled Mutiple-center Clinical Research on the Treatment With Yangzhengxiaoji Capsule Combination Chemotherapy for III/IV Diffuse Large B Cell Lymphoma Unknown status NCT01949818 Phase 4 Yangzhengxiaoji capsule combined with CHOP regimen;CHOP regimen
6 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
7 LINFOTARGAM: First-line Treatment With Dose-dense Chemotherapy Plus Rituximab (R-CHOP/14) and Highly Active Antiretroviral Therapy (HAART) in Patients With Diffuse Large B Cell Lymphoma (DLBCL) and Infection With the Human Immunodeficiency Virus (HIV) Completed NCT00466258 Phase 4 R-CHOP;Highly active antiretroviral therapy;Central nervous system (CNS) prophylaxis;Prophylaxis of opportunistic infections and support treatment
8 Four Cycles of R-CHOP Followed by Four Cycles of Rituximab Versus Six Cycles of R-CHOP Followed by Two Cycles of Rituximab in the Treatment of de Novo, Low-risk, Non-bulky Diffuse Large B-cell Lymphoma. Recruiting NCT02752815 Phase 4 Rituximab;Cyclophosphamide;Epirubicin;Vincristine;Prednisone
9 A Phase 4, Open-label, Single-Arm Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma Active, not recruiting NCT01909934 Phase 4 brentuximab vedotin
10 A Multicenter Prospective Study of Treatment ALK(+) Systemic Anaplastic Large Cell Lymphoma With Crizotinib Withdrawn NCT02487316 Phase 4 crizotinib
11 A Phase III, Open-Label, Prospective, Two-Armed, Multicenter, Randomized, Group Sequential Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) Study Regimen Versus Observation in Patients With Diffuse Large B-Cell Lymphoma Who Are in Complete Remission After First-Line CHOP-Rituximab (CHOP-R) Therapy Unknown status NCT00322218 Phase 3 Zevalin Therapeutic Regimen
12 International Protocol for the Treatment of Childhood Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;therapeutic hydrocortisone;vinblastine sulfate
13 A Multi-center, Prospective, Randomized Phase III Study of the Safety and Efficacy of R-CEOP-90/R-CEOP-70 Versus R-CHOP-50 in the Treatment of Diffuse Large B-cell Lymphoma and Follicular Lymphoma Grade 3B Unknown status NCT01852435 Phase 3 R-CEOP-70;R-CEOP-90;R-CHOP-50
14 A Randomised Multicentric Phase III Study for the Treatment of Young Patients With High Risk (IPI 2-3) Diffuse Large B-Cell Lymphoma. Dose Dense Chemotherapy + Rituximab +/- Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cells. Unknown status NCT00499018 Phase 3 Rituximab;Ciclofosfamide;Doxorubicina;Vincristina;Prednisone;Pegfilgrastim;Mitoxantrone;ARA-C;Lenograstim;BCNU;ARA-C;VP-16;Ciclofosfamide;Doxorubicina;Vincristina
15 A Phase Ⅲ, Multi-center, Randomized, Controlled Study to Compare the Efficiency and Safety of SCT400(Recombinant Chimeric Anti-CD20 Monoclonal Antibody, Experimental Drug) Plus CHOP Versus Rituximab Plus CHOP in Untreated CD20-positive DLBCL Patients Unknown status NCT02772822 Phase 3 SCT400 plus CHOP;Rituximab plus CHOP
16 Phase III,Randomized Controlled Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma Unknown status NCT02767674 Phase 3 Rituximab;Gemcitabine;Oxaliplatin;Cyclophosphamide;Epirubicin Injectable Product;Vindesine;Prednisone
17 High-dose Chemotherapy and Autologous Stem Cell Transplant or Consolidating Conventional Chemotherapy in Primary CNS Lymphoma - Randomized Phase III Trial Unknown status NCT02531841 Phase 3 Arm A (Fortecortin®-ETOPOPHOS®-IFO-cell®-CARBO-cell®);Arm B (TEPADINA®-CARMUBRIS®-Busilvex®)
18 A Prospective, Open, Randomized Controlled, Multi-center Phase III Clinical Trial Comparing High-dose Epirubicin and Standard-dose Epirubicin in R±CEOP in Newly Diagnosed Young Patients With Medium/High-risk Diffuse Large B-cell Lymphoma Unknown status NCT03151044 Phase 3 High-dose Epirubicin Combined with CVP ± Rituximab;Standard-dose Epirubicin Combined with CVP ± Rituximab
19 Study Evaluating Relapses in Central Nervous System in Patients With Diffuse Large B-Cell Lymphoma Treated With Chemotherapy With or Without CNS Prophylaxis. Multicentric, Prospective, Randomized Phase III Study Unknown status NCT02777736 Phase 3 Methotrexate
20 R-CHOP Therapy Compared With R-CHOP Plus Biocell Natural Killer Mixture in Patients With DLBCL (Diffuse Large B Cell Lymphoma);A Randomized, Open-label,Multi-center Trail Unknown status NCT00846157 Phase 3
21 Comparative,Randomized,Double Blind Study to Evaluate Biologic Effect and Safety of PBO-326 (Rituximab), Associated to CHOP-14 Compared With Mabthera (Rituximab) Associated to CHOP-14 in B Cells CD20+ Diffuse Non-Hodgkin Lymphoma Patients Unknown status NCT01277172 Phase 2, Phase 3
22 A Multicenter,Randomized, Controlled (Comparative), Open, Prospective Study Evaluating an Efficacy of R-DA-EPOCH and R-CEOP90, With or Without Upfront Auto-HSCT,in Newly Diagnosed Young Patients With Intermediate/High-risk DLBCL Unknown status NCT03213977 Phase 3 R-DA-EPOCH;R-DA-EPOCH + auto-HSCT;R-CEOP90;R-CEOP90 + auto-HSCT
23 Phase 3 Study of 30Gy Versus 40Gy Involved-field Radiotherapy in Localized Diffuse Large B Cell Lymphoma Achieving CR After Chemotherapy Unknown status NCT01156259 Phase 3
24 Incidence of HBV Reactivation in HBsAg Negative/HBcAb Positive Diffuse Large B Cell Lymphoma or High Grade Follicular Lymphoma Patients: A Prospective Study Unknown status NCT01210287 Phase 2, Phase 3 nucleoside analog reverse transcriptase inhibitor
25 Study of R-ACVBP and DA-EPOCH-R in Patients With Newly Diagnosed Non-germinal Center B-cell-like Diffuse Large B-cell Lymphoma Unknown status NCT03018626 Phase 3 Rituximab;Etoposide;Doxorubicin;Vincristine;Cyclophosphamide;Prednisone;Doxorubicin;Cyclophosphamide;Vindesine;Bleomycin
26 Rituximab, Cyclophosphamide, Vincristine, and Prednisone in Combination With Doxorubicin (R-CHOP) Versus in Combination With Pegylated-liposomal Doxorubicin (R-CDOP) as First-line Treatment for Elderly Patients With Diffuse Large-B-cell Lymphoma: a Randomised, Multicentre, Non-inferiority Study Unknown status NCT02428751 Phase 3 Pegylated liposomal doxorubicin;Doxorubicin;Rituximab;Cyclophophamide;Vincristine;Prednisone
27 Busulfan+ Cyclophosphamide+ Etoposide vs Busulfan+ Cyclophosphamide Conditioning Regimen for Diffuse Large B-cell Lymphoma Undergoing Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT03229616 Phase 2, Phase 3 Busulfan (BU);Cyclophosphamide (CY);Etoposide (VP-16)
28 An Randomized, Open-label, Phase III Study Comparing Thalidomide Combined With R-CHOP and R-CHOP in Newly Diagnosed Double-expressor Diffuse Large B-Cell Lymphoma Patients Unknown status NCT03318835 Phase 3 Thalidomide combined with R-CHOP;R-CHOP
29 Randomized Study of ICE Plus RITUXIMAB Versus DHAP Plus Rituximab in Previously Treated Patients With Diffuse Large B-cell Lymphoma, Followed by Randomized Maintenance With Rituximab Completed NCT00137995 Phase 3 Rituximab;Etoposide;Carboplatine;Ifosfamide + Mesna;Cisplatine;Cytosine Arabinoside;Dexamethasone;BCNU;Etoposide;Cytarabine;Melphalan
30 Prospective Study of ACVBP Followed by Autologous Stem Cell Transplantation in Case of BCL-2 Overexpression in Non Previously Treated Patients Aged 60 Years or Less With Low-Intermediate Risk Diffuse Large B-Cell Lymphoma Completed NCT00169130 Phase 2, Phase 3 doxorubicin;cyclophosphamide
31 Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy Followed by Autologous Stem Cell Transplant (ASCT) in Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL) Completed NCT01014208 Phase 3 OFATUMUMAB + DHAP;RITUXIMAB + DHAP
32 A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients With CD30-positive Mature T-cell Lymphomas Completed NCT01777152 Phase 3 brentuximab vedotin;doxorubicin;prednisone;vincristine;cyclophosphamide
33 A Randomized, Open-Label, Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Patients With CD30-Positive Cutaneous T-Cell Lymphoma Completed NCT01578499 Phase 3 Brentuximab Vedotin;Methotrexate;Bexarotene
34 A Phase III Trial of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma (ALCL) With Standard APO (Doxorubicin, Prednisone, Vincristine) Versus Consolidation With a Regimen Including Vinblastine Completed NCT00059839 Phase 3 doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;vinblastine sulfate;vincristine sulfate
35 Randomized Study of ACVBP Plus Rituximab Versus CHOP Plus Rituximab in Patients Aged From 18 to 59 Years With Diffuse Large B-cell Lymphoma and a Age-adjusted IPI of 1. Completed NCT00140595 Phase 3 rituximab;doxorubicin;cyclophosphamide
36 Intensified CHOP Plus Rituximab (R-CHOP 14) Versus CHOP Plus Rituximab (R-CHOP 21) and Frontline/Prophylactic Darbepoetin Alfa Treatment Versus Usual Symptomatic Treatment of Anemia in Patients Aged 60 to 80 Years With Diffuse Large B-cell Lymphoma. Completed NCT00144755 Phase 3 Darbepoetin alfa
37 A Phase 2/3, Multicenter, Randomized, Open-label Study to Compare the Efficacy and Safety of Lenalidomide (Revlimid ®) Versus Investigator's Choice in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma Completed NCT01197560 Phase 2, Phase 3 Lenalidomide;Gemcitabine;Oxaliplatin;Rituximab;Etoposide
38 A Multicentre, Randomized Phase III Study of Rituximab as Maintenance Treatment Versus Observation Alone in Patients With Aggressive B-cell Lymphoma: NHL-13 Completed NCT00400478 Phase 3 Rituximab
39 Multicentric Randomized Phase III Study Comparing High Doses of Chemotherapy With Rituximab Followed by Auto-transplant HPC Versus CHOP Plus Rituximab as First Line Therapy in High Risk Patients With DLBCL Non-Hodgkin's Lymphomas Completed NCT00355199 Phase 3 Rituximab-HDS;Rituximab-CHOP
40 Phase II Randomized Study With R-DHAP +/- Bortezomib as Induction Therapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL) Patients Eligible to Transplantation. BR-DHAP Versus R-DHAP. Completed NCT01805557 Phase 2, Phase 3 R-DHAP;BR-DHAP
41 A Multicenter, Randomized, Double-blind, Controlled, Phase III Study to Evaluate the Efficacy and Safety of IBI301 (Recombinant Chimeric Anti-CD20 Monoclonal Antibody ) in Combination With CHOP Regimen Versus Rituximab in Combination With CHOP Regimen in Treatment-naïve Patients With Diffuse Large B-cell Lymphoma (DLBCL) Completed NCT02867566 Phase 3 IBI301 plus CHOP;Rituximab plus CHOP
42 An Open-labeled, Multi-center, Randomized, Prospective Phase III Study Comparing CMAB304 in Combination With CHOP to CHOP Alone With CMAB304 Maintenance in Patients With DLBCL Completed NCT01459887 Phase 3 CHOP combined with CMAB304;CHOP, CMAB304
43 A Randomized, Double-blind, Phase III Study Comparing Biosimilar Rituximab (RTXM83) Plus CHOP Chemotherapy Versus a Reference Rituximab Plus CHOP (R-CHOP) in Patients With Diffuse Large B-cell Lymphoma (DLBCL) Given as First Line Completed NCT02268045 Phase 3
44 A Randomized Multicenter Study Comparing Pixantrone + Rituximab With Gemcitabine + Rituximab in Patients With Aggressive B-cell Non-Hodgkin Lymphoma Who Have Relapsed After Therapy With CHOP-R or an Equivalent Regimen and Are Ineligible for Stem Cell Transplant Completed NCT01321541 Phase 3 Pixantrone + Rituximab;Gemcitabine + Rituximab
45 A Randomized, Open-label, Mutli-centre Study to Evaluate Patient Preference With Subcutaneous Administration of Rituximab Versus Intravenous Rituximab in Previously Untreated Patients With CD20+ Diffuse Large B-cell Lymphoma or CD20+ Follicular Non-Hodgkin's Lymphoma Grades 1, 2, OR 3A Completed NCT01724021 Phase 3 Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone/Prednisolone (CHOP);Cyclophosphamide, Vincristine, Prednisone/Prednisolone (CVP);Bendamustine;Rituximab;Rituximab;Rituximab;Rituximab
46 Randomized, Parallel-group, Double-blind, Comparative Bioequivalence Trial of MabionCD20 (Mabion SA) Compared to MabThera (Rituximab by Hoffman-La Roche) in Patients With Diffuse Large B-cell Lymphoma Completed NCT02617485 Phase 3 Rituximab;Doxorubicin;Vincristine;Cyclophosphamide;prednisone
47 A Randomized, Double-blind, Placebo-controlled, Multi-center Phase III Study of RAD001 Adjuvant Therapy in Poor Risk Patients With Diffuse Large B-Cell Lymphoma (DLBCL) of RAD001 Versus Matching Placebo After Patients Have Achieved Complete Response With First-line Rituximab-chemotherapy Completed NCT00790036 Phase 3 Everolimus;Everolimus Placebo
48 Phase III Rituxan/BEAM vs. Bexxar/BEAM With Autologous Hematopoietic Stem Cell Transplantation (ASCT) for Persistent or Relapsed Chemotherapy Sensitive Diffuse Large B-cell Non-Hodgkin's Lymphoma (BMT CTN #0401) Completed NCT00329030 Phase 3 Autologous transplantation using rituxan/BEAM;Autologous transplantation using Bexxar/BEAM
49 Total Body Irradiation, Etoposide, Cyclophosphamide and Autologous Peripheral Blood Stem Cell Transplantation Followed by Randomization to Therapy With Interleukin-2 Versus Observation for Patients With Non-Hodgkin's Lymphoma Completed NCT00002649 Phase 3 cyclophosphamide;etoposide
50 INSPIRE: An Internet-based RCT for Long-term Survivors of Hematopoietic Stem Cell Transplantation Completed NCT00799461 Phase 3

Search NIH Clinical Center for Reticulosarcoma

Genetic Tests for Reticulosarcoma

Anatomical Context for Reticulosarcoma

MalaCards organs/tissues related to Reticulosarcoma:

40
T Cells, Spleen, Thyroid, Skin, Small Intestine, B Cells, Liver

Publications for Reticulosarcoma

Articles related to Reticulosarcoma:

(show top 50) (show all 1202)
# Title Authors PMID Year
1
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis. 61
31759344 2019
2
Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases. 61
30715765 2019
3
[New therapeutic strategies in non-Hodgkin lymphomas and Hodgkin lymphoma]. 61
29801709 2019
4
Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas. 61
29581544 2018
5
l-Asparaginase: a feasible therapeutic molecule for multiple diseases. 61
29872609 2018
6
Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type. 61
28011041 2017
7
Comparison of primer sets for T-cell clonality testing in canine intestinal lymphoma. 61
26319600 2015
8
Cytodiagnosis of the primary breast lymphoma in a young woman. 61
24648678 2013
9
Prognostic value of interim (18)F-FDG PET/CT in diffuse large B-cell lymphoma. 61
23372347 2013
10
[Implications of ALK (anaplastic lymphoma kinase) in oncohematology]. 61
20483705 2010
11
Common misdiagnoses in lymphomas and avoidance strategies. 54
20227918 2010
12
Aggressive nasal-type natural killer/T-cell lymphoma associated with Epstein Barr virus presenting as testicular tumor. 54
20415195 2010
13
Lymphoma, leukemia, and pleiocytosis in cerebrospinal fluid: is accurate cytopathologic diagnosis possible based on morphology alone? 61
19526571 2009
14
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. 54
19825801 2009
15
Vitreous metastases of primary cutaneous B-cell lymphoma. 61
19831568 2009
16
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. 54
19275511 2009
17
Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+, cutaneous lymphocyte antigen negative. 54
18670345 2008
18
Domestic and farm-animal exposures and risk of non-Hodgkin's lymphoma in a population-based study in the San Francisco Bay Area. 61
18768507 2008
19
Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas. 61
18492688 2008
20
[Expression of ALK protein in large cell lymphoma with ALCL chromosome translocation in relation to prognosis]. 54
18549625 2008
21
Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy. 54
17694547 2008
22
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. 54
18089725 2007
23
Follicular lymphoma with trisomy 18 exhibiting loss of BCL-2 expression on transformation to a large cell lymphoma. 54
17182663 2007
24
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. 54
17464320 2007
25
High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. 61
17531143 2007
26
Fascin expression in diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and classical Hodgkin lymphoma. 54
17488159 2007
27
Posttransplantation lymphoproliferative disorders in renal transplant recipients: report of over 20 years of experience. 61
17524894 2007
28
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma. 54
17332315 2007
29
Follicular dendritic cell tumor as an unknown primary tumor. 54
17380443 2007
30
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. 54
16825495 2006
31
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. 54
16763206 2006
32
Chemokine receptor expression in cutaneous T cell and NK/T-cell lymphomas: immunohistochemical staining and in vitro chemotactic assay. 54
16931956 2006
33
Mortality rates among chemical workers in the Kanawha Valley of West Virginia: 1940-1999. 61
17111678 2006
34
Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers. 54
16596703 2006
35
The role of high-dose therapy in peripheral T-cell lymphomas. 54
16640812 2006
36
Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase. 54
16451066 2006
37
CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. 54
16412214 2006
38
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. 54
16189272 2006
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p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. 54
16105984 2005
40
Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. 54
16151469 2005
41
p53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma. 54
15990866 2005
42
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase. 54
15928040 2005
43
CD26 regulates p38 mitogen-activated protein kinase-dependent phosphorylation of integrin beta1, adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 299. 54
16061680 2005
44
Immunohistochemical detection of BCL-3 in lymphoid neoplasms: a survey of 353 cases. 54
15105810 2004
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Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. 54
15208656 2004
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TIA-1 expression in hairy cell leukemia. 54
15073603 2004
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Risk of sudden death in the Williams-Beuren syndrome. 61
15150772 2004
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Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas. 54
14712286 2004
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Caspase-3 activation in systemic anaplastic large-cell lymphoma. 54
14657946 2004
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Mortality among a cohort of uranium mill workers: an update. 61
14691274 2004

Variations for Reticulosarcoma

Expression for Reticulosarcoma

Search GEO for disease gene expression data for Reticulosarcoma.

Pathways for Reticulosarcoma

Pathways related to Reticulosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TNFRSF8 SERPINA3 PTPRC MUC1 FSCN1 CDKN1B
2
Show member pathways
13.19 TNFRSF8 MUC1 FSCN1 CASP3 BCL6 BCL2
3 12.68 CDKN1B CCND3 CASP3 BCL2 ALK
4
Show member pathways
12.66 CDKN1B CCND3 CASP3 BCL2 B2M
5
Show member pathways
12.49 PARP1 GZMB CDKN1B CCND3 CASP3
6
Show member pathways
12.2 CDKN1B CCND3 CASP3 BCL2
7 12.09 PAX5 GZMB CDKN1B BCL6
8
Show member pathways
11.97 PARP1 GZMB CASP3 BCL2
9 11.76 CDKN1B CASP3 BCL2
10 11.73 CDKN1B CCND3 BCL6 BCL2
11 11.72 PARP1 CASP3 BCL2
12 11.71 CDKN1B CASP3 BCL2
13 11.68 MUC1 FSCN1 BCL6 BCL2
14 11.62 TIA1 PARP1 GZMB CASP3 BCL2
15 11.61 TNFRSF8 PTPRC PAX5 GZMB BCL6 B2M
16
Show member pathways
11.38 PARP1 GZMB CASP3
17 11.35 PAX5 CDKN1B BCL2 ANPEP
18 11.3 CDKN1B CASP3 BCL2
19 10.79 PARP1 CASP3 BCL2

GO Terms for Reticulosarcoma

Biological processes related to Reticulosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.83 NPM1 CDKN1B CASP3 BCL6 BCL2
2 neutrophil degranulation GO:0043312 9.77 SERPINA3 PTPRC CD68 B2M ANPEP
3 negative regulation of cell proliferation GO:0008285 9.72 TNFRSF8 NPM1 CDKN1B BCL6 BCL2
4 B cell differentiation GO:0030183 9.58 PTPRC BCL6 BCL2
5 regulation of cell proliferation GO:0042127 9.56 CDKN1B CCND3 BCL6 ALK
6 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.46 MUC1 BCL2
7 cytokine-mediated signaling pathway GO:0019221 9.35 MUC1 FSCN1 CASP3 BCL6 BCL2
8 positive regulation of B cell proliferation GO:0030890 9.33 PTPRC BCL6 BCL2
9 response to gamma radiation GO:0010332 8.8 PTPRC PARP1 BCL2

Molecular functions related to Reticulosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.02 PTPRC PARP1 NPM1 CDKN1B CCND3
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1B CASP3

Sources for Reticulosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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