MCID: RTC009
MIFTS: 44

Reticulum Cell Sarcoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Reticulum Cell Sarcoma

MalaCards integrated aliases for Reticulum Cell Sarcoma:

Name: Reticulum Cell Sarcoma 57 58 17
Dendritic Cell Sarcoma, Interdigitating 70
Interdigitating Dendritic Cell Sarcoma 58
Interdigitating Cell Sarcoma 58
Reticulosarcoma 70

Characteristics:

Orphanet epidemiological data:

58

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal recessive in several families


HPO:

31
reticulum cell sarcoma:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

OMIM® 57 267730
MESH via Orphanet 45 D054739
ICD10 via Orphanet 33 C96.4
UMLS via Orphanet 71 C0024302 C1260326
Orphanet 58 ORPHA86900
MedGen 41 C0024302
UMLS 70 C0024302 C1260326

Summaries for Reticulum Cell Sarcoma

MalaCards based summary : Reticulum Cell Sarcoma, also known as dendritic cell sarcoma, interdigitating, is related to spindle cell sarcoma and lymphosarcoma, and has symptoms including fatigue, fever and night sweats. An important gene associated with Reticulum Cell Sarcoma is S100A1 (S100 Calcium Binding Protein A1), and among its related pathways/superpathways are Innate Immune System and Cytoskeletal Signaling. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thyroid, and related phenotypes are sarcoma and cellular

More information from OMIM: 267730

Related Diseases for Reticulum Cell Sarcoma

Diseases related to Reticulum Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.5 VIM MUC1 DES ACTC1
2 lymphosarcoma 31.0 TNFRSF8 PTPRC
3 retroperitoneal fibrosis 30.3 VIM PTPRC
4 follicular lymphoma 30.3 FCER2 CR2 CR1
5 histiocytic and dendritic cell cancer 30.3 TNFRSF8 PTPRC CR2 CR1
6 langerhans cell sarcoma 30.3 CR2 CR1
7 interdigitating dendritic cell sarcoma 30.3 CR2 CR1
8 rare tumor 30.2 FCER2 DES CR2 ACTC1
9 follicular dendritic cell sarcoma 30.2 FCER2 CR2 CR1
10 malignant peripheral nerve sheath tumor 30.2 VIM S100A1 MUC1 ACTC1
11 cerebral lymphoma 30.1 TNFRSF8 CD4
12 pfeiffer syndrome 30.1 TNFRSF8 CR2 CD4
13 pleural empyema 30.0 TNFRSF8 CD4
14 mature t-cell and nk-cell lymphoma 30.0 TNFRSF8 CR2 CD4 CD2
15 anaplastic large cell lymphoma 30.0 TNFRSF8 PTPRC MUC1 CD4
16 parapsoriasis 30.0 TNFRSF8 CD4 CD2
17 leiomyosarcoma 29.9 VIM S100A1 MUC1 DES ACTC1
18 ewing sarcoma 29.6 VIM TNFRSF8 PTPRC DES
19 reticulosarcoma 29.5 TNFRSF8 PTPRC MUC1
20 b-cell lymphoma 29.2 TNFRSF8 PTPRC FCER2 CR2
21 leukemia, chronic lymphocytic 28.9 TNFRSF8 PTPRC FCER2 CR2 CR1 CD4
22 dendritic cell tumor 28.7 VIM PTPRC MUC1 FCER2 CR2 CR1
23 sarcoma 11.1
24 melanoma 10.6
25 brain sarcoma 10.6
26 uveitis 10.5
27 lymphoma 10.4
28 malignant spindle cell melanoma 10.4
29 posttransplant acute limbic encephalitis 10.4
30 lymphangiectasis 10.4 VIM ACTC1
31 intravascular papillary endothelial hyperplasia 10.4 VIM ACTC1
32 glomangiomyoma 10.4 VIM ACTC1
33 angiocentric glioma 10.3 VIM ACTC1
34 mast-cell sarcoma 10.3 VIM CD2
35 myofibroma 10.3 S100A1 DES
36 granuloma annulare 10.3 VIM CD4
37 infantile digital fibromatosis 10.3 VIM DES
38 lymphangiomatosis 10.3 VIM DES
39 fibroblastic rheumatism 10.3 DES ACTC1
40 ovarian fibrothecoma 10.3 DES ACTC1
41 granulosa cell tumor of the ovary 10.3 VIM ACTC1
42 congenital epulis 10.3 VIM DES
43 epulis 10.3 VIM DES
44 parapharyngeal meningioma 10.3 CR2 CR1
45 systemic epstein-barr virus-positive t-cell lymphoma of childhood 10.3 CR2 CD2
46 pancytopenia 10.3
47 chromosomal triplication 10.3
48 adult cystic nephroma 10.3 DES ACTC1
49 granulomatous gastritis 10.3 CR2 CR1
50 pulmonary vein stenosis 10.3 DES ACTC1

Graphical network of the top 20 diseases related to Reticulum Cell Sarcoma:



Diseases related to Reticulum Cell Sarcoma

Symptoms & Phenotypes for Reticulum Cell Sarcoma

Human phenotypes related to Reticulum Cell Sarcoma:

31
# Description HPO Frequency HPO Source Accession
1 sarcoma 31 HP:0100242

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Oncology:
reticulum cell sarcoma

Clinical features from OMIM®:

267730 (Updated 05-Apr-2021)

UMLS symptoms related to Reticulum Cell Sarcoma:


fatigue; fever; night sweats

MGI Mouse Phenotypes related to Reticulum Cell Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 ACTC1 CD4 DES FCER2 LYVE1 PTPRC
2 hematopoietic system MP:0005397 9.28 ACTC1 CD4 CR2 FCER2 LYVE1 PTPRC

Drugs & Therapeutics for Reticulum Cell Sarcoma

Drugs for Reticulum Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antineoplastic Agents, Immunological Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Pembrolizumab in Patients With Histiocyte/Dendritic Cell Neoplasms and Biologically Selected Subtypes of Relapsed/Refractory Aggressive Lymphomas Recruiting NCT03316573 Phase 2 Pembrolizumab

Search NIH Clinical Center for Reticulum Cell Sarcoma

Genetic Tests for Reticulum Cell Sarcoma

Anatomical Context for Reticulum Cell Sarcoma

MalaCards organs/tissues related to Reticulum Cell Sarcoma:

40
Bone, Brain, Thyroid, Small Intestine, Spleen, Skin, Testis

Publications for Reticulum Cell Sarcoma

Articles related to Reticulum Cell Sarcoma:

(show top 50) (show all 2136)
# Title Authors PMID Year
1
Extra-nodal Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma Presenting as a Colonic Polyp: Report of a Rare Case with Review of Literature. 61
32124238 2020
2
Fine-Needle Cytological Characteristics of Carcinoma Breast with Medullary or Medullary-like Features Masquerading as Dendritic Reticulum Cell Sarcoma: An Attempt to Explore the Reasons for Erroneous Cytologic Interpretation. 61
32606498 2020
3
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-ŮŽAnalysis. 61
31759344 2019
4
l-Asparaginase: a feasible therapeutic molecule for multiple diseases. 61
29872609 2018
5
Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3. 61
26815506 2016
6
Mosquito vectors and the spread of cancer: an overlooked connection? 61
27053131 2016
7
[Recent advances in transmissible tumors]. 61
26582522 2015
8
Systemic involvement in mycosis fungoides. 61
26321404 2015
9
A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity. 61
27217677 2015
10
Cytokeratin-positive interstitial reticulum cell sarcoma: extranodal presentations mimicking carcinoma. 61
24056661 2013
11
[Reticulum cell sarcoma misdiagnosed as acute osteomyelitis: a report of 1 case]. 61
20963994 2010
12
Cytokeratin-positive interstitial reticulum cell sarcoma: a case report with cytological, immunohistochemical, and ultrastructural findings. 61
19207304 2009
13
Metastatic fibroblastic reticulum cell sarcoma of the liver: pathological and PET-CT evaluation. 61
19291544 2009
14
Sarcoma of follicular dendritic cells with features of sinus lining cells--a new subtype of reticulum cell sarcoma? 61
18386053 2008
15
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model. 61
18378905 2008
16
Mortality rates among chemical workers in the Kanawha Valley of West Virginia: 1940-1999. 61
17111678 2006
17
Primary cutaneous B-cell lymphomas: then and now. 61
16412206 2006
18
Malignant epithelioid ovarian schwannoma: a case report. 61
16515623 2006
19
Interdigitating dendritic reticulum cell sarcoma: cytologic, histologic and immunocytochemical features. 61
15945093 2005
20
[Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology]. 61
15164222 2004
21
[A rare cardiac tumor: the malignant fibrous histiocytoma. Description of a case]. 61
15554023 2004
22
Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations. 61
15063382 2004
23
Risk of sudden death in the Williams-Beuren syndrome. 61
15150772 2004
24
Mortality among a cohort of uranium mill workers: an update. 61
14691274 2004
25
Multifocal pigment epithelial detachments by reticulum cell sarcoma: a characteristic funduscopic picture. 1984. 61
15035397 2003
26
Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes. 61
12843642 2003
27
[Gastric interdigitating reticulum cell sarcoma: unusual presentation of a histiocytic tumor]. 61
12122368 2002
28
Antitumor efficacy in vitro and in vivo of falconensones, a new type of polyene. 61
11705876 2001
29
[Follicular dendritic reticulum cell sarcoma in a cervical lymph node]. 61
11699145 2001
30
Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. 61
11598178 2001
31
Cutaneous T cell lymphoma: the helping hand of dendritic cells. 61
11594563 2001
32
Sclerosing cholangitis in the paediatric patient. 61
11492976 2001
33
The classification of lymphomas and leukemias. 61
11397419 2001
34
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. 61
11426330 2001
35
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity. 61
11306484 2001
36
Improved in vivo antitumor efficacy and reduced systemic toxicity of carboxymethylpullulan-peptide-doxorubicin conjugates. 61
11123434 2000
37
Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver. 61
10955826 2000
38
Vascularized free fibular transfer combined with autografting for the management of fracture nonunions associated with radiation therapy. 61
10761944 2000
39
Unusual primary tumors of the heart. 61
10807431 2000
40
Gastric cancer profile in kashmiri population with special dietary habits. 61
18493530 2000
41
Augmentation of local antitumor immunity in the liver by tumor vaccine modified to secrete murine interleukin 12. 61
10455415 1999
42
Delivery of methoxymorpholinyl doxorubicin by interleukin 2-activated NK cells: effect in mice bearing hepatic metastases. 61
10098738 1999
43
Molecular and phylogenetic analysis of SRS 19-6 murine leukemia virus. 61
10334039 1999
44
A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: trans-(n-valerato)chloro(1R,2R-cyclohexanediamine) (oxalato)platinum(IV). 61
9923814 1999
45
The antitumor efficacy of cytotoxic drugs is potentiated by treatment with PNU 145156E, a growth-factor-complexing molecule. 61
9923555 1999
46
Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. 61
9839165 1998
47
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. 61
9766802 1998
48
Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mouse models. 61
9703260 1998
49
Combination of cisplatin-procaine complex DPR with anticancer drugs increases cytotoxicity against ovarian cancer cell lines. 61
9660544 1998
50
FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome. 61
9619755 1998

Variations for Reticulum Cell Sarcoma

Expression for Reticulum Cell Sarcoma

Search GEO for disease gene expression data for Reticulum Cell Sarcoma.

Pathways for Reticulum Cell Sarcoma

Pathways related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 VIM TNFRSF8 S100A9 S100A1 PTPRC MUC1
2 11.95 VIM MUC1 DES ACTC1
3 11.75 PTPRC CD4 CD2
4 11.56 PTPRC CD4 CD2
5 11.49 VIM MUC1 FCER2
6 11.02 FCER2 CR2 CR1 CD4 CD2
7 10.99 VIM DES ACTC1

GO Terms for Reticulum Cell Sarcoma

Cellular components related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.07 VIM TNFRSF8 S100A9 PTPRC MUC1 LYVE1
2 plasma membrane GO:0005886 9.73 VIM TNFRSF8 S100A9 PTPRC MUC1 LYVE1
3 integral component of plasma membrane GO:0005887 9.7 PTPRC MUC1 LYVE1 FCER2 CR1 CD4
4 external side of plasma membrane GO:0009897 9.62 PTPRC FCER2 CD4 CD2
5 extracellular exosome GO:0070062 9.36 VIM TNFRSF8 S100A9 PTPRC MUC1 LYVE1

Biological processes related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 VIM MUC1 FCER2 CD4
2 viral process GO:0016032 9.65 VIM PTPRC CR2 CR1 CD4
3 positive regulation of tumor necrosis factor production GO:0032760 9.5 TNFRSF8 PTPRC CD2
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.49 S100A1 FCER2
5 intermediate filament organization GO:0045109 9.48 VIM DES
6 astrocyte development GO:0014002 9.46 VIM S100A9
7 complement activation, alternative pathway GO:0006957 9.43 CR2 CR1
8 complement receptor mediated signaling pathway GO:0002430 9.4 CR2 CR1
9 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.16 PTPRC FCER2
10 T cell activation GO:0042110 9.13 PTPRC CD4 CD2
11 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 CR2 CR1 CD4
2 transmembrane signaling receptor activity GO:0004888 8.92 TNFRSF8 LYVE1 CR2 CD4

Sources for Reticulum Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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