MCID: RTC009
MIFTS: 45

Reticulum Cell Sarcoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Reticulum Cell Sarcoma

MalaCards integrated aliases for Reticulum Cell Sarcoma:

Name: Reticulum Cell Sarcoma 57 59 17
Dendritic Cell Sarcoma, Interdigitating 72
Interdigitating Dendritic Cell Sarcoma 59
Interdigitating Cell Sarcoma 59
Reticulosarcoma 72

Characteristics:

Orphanet epidemiological data:

59

OMIM:

57
Inheritance:
autosomal recessive in several families


HPO:

32
reticulum cell sarcoma:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 267730
MESH via Orphanet 45 D054739
ICD10 via Orphanet 34 C96.4
UMLS via Orphanet 73 C0024302 C1260326
Orphanet 59 ORPHA86900
MedGen 42 C0024302
UMLS 72 C0024302 C1260326

Summaries for Reticulum Cell Sarcoma

MalaCards based summary : Reticulum Cell Sarcoma, also known as dendritic cell sarcoma, interdigitating, is related to spindle cell sarcoma and histiocytic and dendritic cell cancer, and has symptoms including fever, fatigue and night sweats. An important gene associated with Reticulum Cell Sarcoma is VIM (Vimentin), and among its related pathways/superpathways are Innate Immune System and Cytoskeletal Signaling. The drugs Pembrolizumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thyroid, and related phenotypes are sarcoma and cellular

More information from OMIM: 267730

Related Diseases for Reticulum Cell Sarcoma

Diseases related to Reticulum Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.8 VIM MUC1 DES ACTC1
2 histiocytic and dendritic cell cancer 30.8 PTPRC CR2 CR1
3 retroperitoneal fibrosis 30.6 VIM PTPRC
4 langerhans cell sarcoma 30.5 CR2 CR1
5 leiomyosarcoma 30.4 VIM S100A1 DES ACTC1
6 follicular dendritic cell sarcoma 30.3 FCER2 CR2 CR1
7 malignant peripheral nerve sheath tumor 30.3 VIM S100A1 MUC1 ACTC1
8 anaplastic large cell lymphoma 30.2 TNFRSF8 PTPRC MUC1
9 interdigitating dendritic cell sarcoma 29.9 PTPRC CR2 CR1
10 spindle cell carcinoma 29.7 VIM MUC1 DES ACTC1
11 reticulosarcoma 29.4 TNFRSF8 PTPRC MUC1
12 ewing sarcoma 29.2 VIM TNFRSF8 S100A1 PTPRC DES
13 dendritic cell tumor 28.0 VIM PTPRC MUC1 FCER2 CR2 CR1
14 sarcoma 11.2
15 lymphangiectasis 10.7 VIM ACTC1
16 lymphangioma 10.7 VIM ACTC1
17 glomangiomyoma 10.7 VIM ACTC1
18 intravascular papillary endothelial hyperplasia 10.7 VIM ACTC1
19 epulis 10.6 VIM DES
20 lymphoma 10.6
21 infantile digital fibromatosis 10.6 VIM DES
22 lymphosarcoma 10.6
23 lymphangiomatosis 10.6 VIM DES
24 ovarian fibrothecoma 10.6 DES ACTC1
25 fibroblastic rheumatism 10.6 DES ACTC1
26 malignant ectomesenchymoma 10.6 S100A1 DES
27 angiocentric glioma 10.6 VIM ACTC1
28 parapharyngeal meningioma 10.6 CR2 CR1
29 polyclonal hypergammaglobulinemia 10.6 CD4 CD2
30 botryoid rhabdomyosarcoma 10.6 DES ACTC1
31 lobomycosis 10.6 CR2 CD2
32 glomangioma 10.5 DES ACTC1
33 malignant peritoneal mesothelioma 10.5 VIM MUC1
34 brain sarcoma 10.5
35 pulmonary vein stenosis 10.5 DES ACTC1
36 secretory meningioma 10.5 VIM MUC1
37 non-langerhans-cell histiocytosis 10.5 DES ACTC1
38 chordoid meningioma 10.5 VIM MUC1
39 fibrous meningioma 10.5 VIM MUC1
40 cystic nephroma 10.5 VIM DES
41 eccrine porocarcinoma 10.5 VIM MUC1
42 clear cell ependymoma 10.5 VIM MUC1
43 juvenile xanthogranuloma 10.5 VIM DES
44 nodular hidradenoma 10.5 VIM MUC1
45 hidradenoma 10.5 VIM MUC1
46 uveitis 10.5
47 endometrial mucinous adenocarcinoma 10.4 VIM MUC1
48 sternum cancer 10.4 VIM TNFRSF8
49 monophasic synovial sarcoma 10.4 VIM MUC1
50 myxopapillary ependymoma 10.4 VIM MUC1

Graphical network of the top 20 diseases related to Reticulum Cell Sarcoma:



Diseases related to Reticulum Cell Sarcoma

Symptoms & Phenotypes for Reticulum Cell Sarcoma

Human phenotypes related to Reticulum Cell Sarcoma:

32
# Description HPO Frequency HPO Source Accession
1 sarcoma 32 HP:0100242

Symptoms via clinical synopsis from OMIM:

57
Oncology:
reticulum cell sarcoma

Clinical features from OMIM:

267730

UMLS symptoms related to Reticulum Cell Sarcoma:


fever, fatigue, night sweats

MGI Mouse Phenotypes related to Reticulum Cell Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 ACTC1 CD4 DES FCER2 LYVE1 PTPRC
2 hematopoietic system MP:0005397 9.23 CD4 CR2 FCER2 LYVE1 PTPRC S100A9

Drugs & Therapeutics for Reticulum Cell Sarcoma

Drugs for Reticulum Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antibodies Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Pembrolizumab in Patients With Histiocyte/Dendritic Cell Neoplasms and Biologically Selected Subtypes of Relapsed/Refractory Aggressive Lymphomas Recruiting NCT03316573 Phase 2 Pembrolizumab

Search NIH Clinical Center for Reticulum Cell Sarcoma

Genetic Tests for Reticulum Cell Sarcoma

Anatomical Context for Reticulum Cell Sarcoma

MalaCards organs/tissues related to Reticulum Cell Sarcoma:

41
Bone, Brain, Thyroid, Lymph Node, Small Intestine, Spleen, Testis

Publications for Reticulum Cell Sarcoma

Articles related to Reticulum Cell Sarcoma:

(show top 50) (show all 2108)
# Title Authors PMID Year
1
l-Asparaginase: a feasible therapeutic molecule for multiple diseases. 38
29872609 2018
2
Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3. 38
26815506 2016
3
Mosquito vectors and the spread of cancer: an overlooked connection? 38
27053131 2016
4
[Recent advances in transmissible tumors]. 38
26582522 2015
5
A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity. 38
27217677 2015
6
Systemic involvement in mycosis fungoides. 38
26321404 2015
7
Cytokeratin-positive interstitial reticulum cell sarcoma: extranodal presentations mimicking carcinoma. 38
24056661 2013
8
[Reticulum cell sarcoma misdiagnosed as acute osteomyelitis: a report of 1 case]. 38
20963994 2010
9
Cytokeratin-positive interstitial reticulum cell sarcoma: a case report with cytological, immunohistochemical, and ultrastructural findings. 38
19207304 2009
10
Metastatic fibroblastic reticulum cell sarcoma of the liver: pathological and PET-CT evaluation. 38
19291544 2009
11
Sarcoma of follicular dendritic cells with features of sinus lining cells--a new subtype of reticulum cell sarcoma? 38
18386053 2008
12
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model. 38
18378905 2008
13
Mortality rates among chemical workers in the Kanawha Valley of West Virginia: 1940-1999. 38
17111678 2006
14
Primary cutaneous B-cell lymphomas: then and now. 38
16412206 2006
15
Malignant epithelioid ovarian schwannoma: a case report. 38
16515623 2006
16
Interdigitating dendritic reticulum cell sarcoma: cytologic, histologic and immunocytochemical features. 38
15945093 2005
17
[Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology]. 38
15164222 2004
18
[A rare cardiac tumor: the malignant fibrous histiocytoma. Description of a case]. 38
15554023 2004
19
Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations. 38
15063382 2004
20
Risk of sudden death in the Williams-Beuren syndrome. 38
15150772 2004
21
Mortality among a cohort of uranium mill workers: an update. 38
14691274 2004
22
Multifocal pigment epithelial detachments by reticulum cell sarcoma: a characteristic funduscopic picture. 1984. 38
15035397 2003
23
Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes. 38
12843642 2003
24
[Gastric interdigitating reticulum cell sarcoma: unusual presentation of a histiocytic tumor]. 38
12122368 2002
25
Antitumor efficacy in vitro and in vivo of falconensones, a new type of polyene. 38
11705876 2001
26
Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. 38
11598178 2001
27
[Follicular dendritic reticulum cell sarcoma in a cervical lymph node]. 38
11699145 2001
28
Cutaneous T cell lymphoma: the helping hand of dendritic cells. 38
11594563 2001
29
Sclerosing cholangitis in the paediatric patient. 38
11492976 2001
30
The classification of lymphomas and leukemias. 38
11397419 2001
31
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. 38
11426330 2001
32
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity. 38
11306484 2001
33
Improved in vivo antitumor efficacy and reduced systemic toxicity of carboxymethylpullulan-peptide-doxorubicin conjugates. 38
11123434 2000
34
Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver. 38
10955826 2000
35
Vascularized free fibular transfer combined with autografting for the management of fracture nonunions associated with radiation therapy. 38
10761944 2000
36
Unusual primary tumors of the heart. 38
10807431 2000
37
Gastric cancer profile in kashmiri population with special dietary habits. 38
18493530 2000
38
Augmentation of local antitumor immunity in the liver by tumor vaccine modified to secrete murine interleukin 12. 38
10455415 1999
39
Delivery of methoxymorpholinyl doxorubicin by interleukin 2-activated NK cells: effect in mice bearing hepatic metastases. 38
10098738 1999
40
Molecular and phylogenetic analysis of SRS 19-6 murine leukemia virus. 38
10334039 1999
41
A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: trans-(n-valerato)chloro(1R,2R-cyclohexanediamine) (oxalato)platinum(IV). 38
9923814 1999
42
The antitumor efficacy of cytotoxic drugs is potentiated by treatment with PNU 145156E, a growth-factor-complexing molecule. 38
9923555 1999
43
Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. 38
9839165 1998
44
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. 38
9766802 1998
45
Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mouse models. 38
9703260 1998
46
Combination of cisplatin-procaine complex DPR with anticancer drugs increases cytotoxicity against ovarian cancer cell lines. 38
9660544 1998
47
Effect of pH on proteinase secretion by transformed fibroblast populations. 38
10730852 1998
48
FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome. 38
9619755 1998
49
Interdigitating reticulum-cell sarcoma of the intestine: a case report and review of the literature. 38
9285196 1997
50
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. 38
9301666 1997

Variations for Reticulum Cell Sarcoma

Expression for Reticulum Cell Sarcoma

Search GEO for disease gene expression data for Reticulum Cell Sarcoma.

Pathways for Reticulum Cell Sarcoma

GO Terms for Reticulum Cell Sarcoma

Cellular components related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.73 VIM TNFRSF8 S100A9 PTPRC MUC1 LYVE1
2 integral component of plasma membrane GO:0005887 9.7 PTPRC MUC1 LYVE1 FCER2 CR1 CD4
3 external side of plasma membrane GO:0009897 9.56 PTPRC FCER2 CD4 CD2
4 I band GO:0031674 9.37 S100A1 ACTC1
5 extracellular exosome GO:0070062 9.36 VIM TNFRSF8 S100A9 PTPRC MUC1 LYVE1
6 membrane GO:0016020 10.1 TNFRSF8 S100A9 PTPRC MUC1 LYVE1 FCER2

Biological processes related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.76 VIM CR2 CR1 CD4
2 cytokine-mediated signaling pathway GO:0019221 9.56 VIM MUC1 FCER2 CD4
3 cytokine production GO:0001816 9.49 S100A9 CD4
4 heterotypic cell-cell adhesion GO:0034113 9.48 PTPRC CD2
5 positive regulation of nitric-oxide synthase activity GO:0051000 9.43 S100A1 FCER2
6 intermediate filament organization GO:0045109 9.4 VIM DES
7 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.37 PTPRC CD4
8 complement receptor mediated signaling pathway GO:0002430 9.32 CR2 CR1
9 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.16 PTPRC FCER2
10 T cell activation GO:0042110 9.13 PTPRC CD4 CD2
11 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Reticulum Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 CR2 CR1 CD4
2 transmembrane signaling receptor activity GO:0004888 8.92 TNFRSF8 LYVE1 CR2 CD4

Sources for Reticulum Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....