MCID: RTN011
MIFTS: 28

Retina Lymphoma

Categories: Neuronal diseases, Cancer diseases, Eye diseases, Immune diseases

Aliases & Classifications for Retina Lymphoma

MalaCards integrated aliases for Retina Lymphoma:

Name: Retina Lymphoma 12 15
Lymphoma of Retina 12 73
Retinal Lymphoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:774
NCIt 50 C4365
SNOMED-CT 68 232075002
UMLS 73 C0339556

Summaries for Retina Lymphoma

MalaCards based summary : Retina Lymphoma, also known as lymphoma of retina, is related to chronic monocytic leukemia and precursor t-cell acute lymphoblastic leukemia. An important gene associated with Retina Lymphoma is MPO (Myeloperoxidase), and among its related pathways/superpathways are C-MYB transcription factor network and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dexamethasone and Pomalidomide have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Retina Lymphoma

Graphical network of the top 20 diseases related to Retina Lymphoma:



Diseases related to Retina Lymphoma

Symptoms & Phenotypes for Retina Lymphoma

GenomeRNAi Phenotypes related to Retina Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.32 TRPV2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.32 CD34
3 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.32 TRPV2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.32 TRPV2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.32 CD34 TRPV2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.32 TRPV2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.32 TRPV2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.32 CD34
9 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.32 TRPV2

MGI Mouse Phenotypes related to Retina Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 CD34 CD68 MPO TRPV2
2 immune system MP:0005387 8.92 CD34 CD68 MPO TRPV2

Drugs & Therapeutics for Retina Lymphoma

Drugs for Retina Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
2 Pomalidomide Approved Phase 1 19171-19-8
3 Dexamethasone acetate Phase 1 1177-87-3
4 glucocorticoids Phase 1
5
protease inhibitors Phase 1
6 Gastrointestinal Agents Phase 1
7 HIV Protease Inhibitors Phase 1
8 Hormone Antagonists Phase 1
9 Angiogenesis Inhibitors Phase 1
10 Hormones Phase 1
11 Angiogenesis Modulating Agents Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
13 Peripheral Nervous System Agents Phase 1
14 Anti-Bacterial Agents Phase 1
15 Immunosuppressive Agents Phase 1
16 Anti-Infective Agents Phase 1
17 Antiemetics Phase 1
18 Anti-Inflammatory Agents Phase 1
19 BB 1101 Phase 1
20 Autonomic Agents Phase 1
21 Antineoplastic Agents, Hormonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma or Newly Diagnosed or Relapsed or Refractory Intraocular Lymphoma Suspended NCT01722305 Phase 1 Dexamethasone;Pomalidomide

Search NIH Clinical Center for Retina Lymphoma

Genetic Tests for Retina Lymphoma

Anatomical Context for Retina Lymphoma

MalaCards organs/tissues related to Retina Lymphoma:

41
Retina, Eye

Publications for Retina Lymphoma

Articles related to Retina Lymphoma:

# Title Authors Year
1
Primary intraocular (retinal) lymphoma following ocular toxoplasmosis. ( 20454548 )
2010
2
Pathophysiology of retinal lymphoma. ( 19657975 )
2009
3
The future of primary intraocular lymphoma (retinal lymphoma). ( 20001255 )
2009

Variations for Retina Lymphoma

Expression for Retina Lymphoma

Search GEO for disease gene expression data for Retina Lymphoma.

Pathways for Retina Lymphoma

Pathways related to Retina Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 CD34 MPO
2 10.86 CD34 CD68 MPO
3 10.16 CD68 MPO

GO Terms for Retina Lymphoma

Sources for Retina Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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