MCID: RTN014
MIFTS: 48

Retinal Artery Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Retinal Artery Occlusion

MalaCards integrated aliases for Retinal Artery Occlusion:

Name: Retinal Artery Occlusion 11 53 14 16 71
Spasm of Ophthalmic Artery 33
Retina Artery Narrowing 33
Retinal Artery Spasm 33
Vasospasm of Retina 33
Retinal Spasm 33

Classifications:



External Ids:

Disease Ontology 11 DOID:8483
MeSH 43 D015356
NCIt 49 C34978
SNOMED-CT 68 232035005
ICD11 33 1344536007
UMLS 71 C0035302

Summaries for Retinal Artery Occlusion

MalaCards based summary: Retinal Artery Occlusion, also known as spasm of ophthalmic artery, is related to central retinal artery occlusion and branch retinal artery occlusion, and has symptoms including amaurosis fugax An important gene associated with Retinal Artery Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Signal Transduction and p70S6K Signaling. The drugs Tenecteplase and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and brain, and related phenotypes are no effect and no effect

Related Diseases for Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 679)
# Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 32.9 VEGFA SERPINC1 PLG MTHFR F2 CRYAA
2 branch retinal artery occlusion 32.7 VEGFA SERPINC1 PLG MTHFR F2 APOH
3 retinal ischemia 32.4 VEGFA PGF IL6 HMOX1 CRYAA
4 optic nerve disease 31.5 VEGFA IL6 IL10 CRYAA ACE
5 carotid stenosis 31.4 VEGFA MTHFR IL10 ACE
6 temporal arteritis 31.4 VEGFA IL6 IL10 ACE
7 amaurosis fugax 31.3 SERPINE1 MTHFR F5
8 retinal vasculitis 31.2 VEGFA APOH ACE
9 nonarteritic anterior ischemic optic neuropathy 31.2 VEGFA SERPINC1 MTHFR F5 F2
10 sickle cell anemia 31.1 SERPINC1 IL6 HMOX1 F2
11 carotid artery disease 31.1 SERPINC1 PLG IL6 ACE
12 neuroretinitis 31.0 VEGFA ACE
13 toxoplasmosis 31.0 IL6 IL10 F2
14 optic neuritis 30.9 VEGFA IL6 IL10
15 neuritis 30.9 VEGFA IL6 IL10
16 orbital cellulitis 30.9 IL6 ACE
17 polycythemia 30.8 VEGFA F5 F2 ACE
18 infective endocarditis 30.8 PLG IL6 F2 ACE
19 chickenpox 30.8 IL6 IL10 F2 ACE
20 uveitis 30.8 VEGFA IL6 IL10 CRYAA
21 chorioretinitis 30.8 VEGFA IL6 IL10 ACE
22 anterior uveitis 30.8 VEGFA IL6 IL10 ACE
23 macular dystrophy, dominant cystoid 30.8 VEGFA IL6 ACE
24 hyperhomocysteinemia 30.8 SERPINE1 SERPINC1 MTHFR F5 F2 APOH
25 acute retinal necrosis syndrome 30.8 VEGFA IL6 IL10 ACE
26 homocystinuria 30.7 SERPINC1 MTHFR F8 F5
27 takayasu arteritis 30.7 MTHFR IL6 IL10
28 macular retinal edema 30.7 VEGFB VEGFA PGF IL6 FLT1 ACE
29 retinal vein occlusion 30.7 VEGFA SERPINE1 SERPINC1 MTHFR IL6 IL10
30 atrial fibrillation 30.7 IL6 F9 F2 ACE
31 choroiditis 30.7 VEGFA IL10 ACE
32 subclavian steal syndrome 30.7 F2 ACE
33 posterior uveitis 30.7 VEGFA IL6 ACE
34 arteries, anomalies of 30.7 VEGFA PLG IL6 ACE
35 endocarditis 30.7 SERPINE1 SERPINC1 IL6 IL10 F2 APOH
36 migraine with aura 30.7 MTHFR IL6 F5 F2 ACE
37 transient cerebral ischemia 30.6 SERPINC1 PLG MTHFR IL6 F2 APOH
38 heart valve disease 30.6 IL6 F2 APOH ACE
39 posterior scleritis 30.6 VEGFA ACE
40 antiphospholipid syndrome 30.6 SERPINE1 SERPINC1 PGF MTHFR F5 F2
41 aortic valve insufficiency 30.6 F2 ACTA2 ACE
42 cerebrovascular disease 30.6 PLG MTHFR IL6 F5 F2 APOH
43 thrombophilia 30.5 SERPINE1 SERPINC1 MTHFR F9 F8 F5
44 vitreous detachment 30.5 VEGFA PLG PGF
45 covid-19 30.5 PLG IL6 IL10 F2 ACE
46 peripheral artery disease 30.5 VEGFA IL6 ACE
47 abducens palsy 30.5 SERPINC1 F2
48 factor viii deficiency 30.5 SERPINC1 F9 F8 F5 F2
49 lipid metabolism disorder 30.5 SERPINE1 IL6 IL10 ACE
50 arteriovenous malformation 30.5 VEGFA PLG F2

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to Retinal Artery Occlusion

Symptoms & Phenotypes for Retinal Artery Occlusion

UMLS symptoms related to Retinal Artery Occlusion:


amaurosis fugax

GenomeRNAi Phenotypes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ACE ACTA2 APOH CRYAA F2 F5
2 no effect GR00402-S-2 10.19 ACE ACTA2 APOH F2 F5 F8

MGI Mouse Phenotypes related to Retinal Artery Occlusion:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACE APOH F2 F5 F8 F9
2 cardiovascular system MP:0005385 10.31 ACE ACTA2 F2 F5 F9 FLT1
3 growth/size/body region MP:0005378 10.3 ACE F2 F5 FLT1 HMOX1 IL10
4 liver/biliary system MP:0005370 10.25 ACE F5 F9 HMOX1 IL10 IL6
5 immune system MP:0005387 10.22 ACE F2 F8 F9 FLT1 HMOX1
6 muscle MP:0005369 10.18 ACTA2 F2 FLT1 HMOX1 IL10 IL6
7 reproductive system MP:0005389 10.1 ACE F2 F8 FLT1 HMOX1 IL10
8 neoplasm MP:0002006 10.08 ACE IL10 IL6 PGF PLG SERPINE1
9 adipose tissue MP:0005375 10.04 ACE F2 HMOX1 IL6 PGF SERPINE1
10 vision/eye MP:0005391 10.03 ACTA2 CRYAA FLT1 HMOX1 IL10 IL6
11 respiratory system MP:0005388 10.02 F2 HMOX1 IL10 IL6 PGF PLG
12 hematopoietic system MP:0005397 9.97 ACE F2 F8 F9 FLT1 HMOX1
13 mortality/aging MP:0010768 9.86 ACE APOH F2 F5 F8 F9
14 integument MP:0010771 9.28 F2 F5 IL10 IL6 MTHFR PGF

Drugs & Therapeutics for Retinal Artery Occlusion

Drugs for Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenecteplase Approved Phase 3 191588-94-0
2
Plasminogen Approved Phase 3 9001-91-6
3
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
4
Acetylsalicylic acid Approved, Vet_approved Phase 3 50-78-2 2244
5
Heparin, bovine Approved, Investigational, Withdrawn Phase 3 9005-49-6 22833565 9812414 772
6
Acetazolamide Approved, Vet_approved Phase 3 59-66-5, 1424-27-7 1986
7 Tissue Plasminogen Activator Phase 3
8 Pharmaceutical Solutions Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Fibrinolytic Agents Phase 3
11 Antirheumatic Agents Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Antipyretics Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Analgesics Phase 3
18 Neurotransmitter Agents Phase 3
19 Adrenergic Antagonists Phase 3
20 Carbonic Anhydrase Inhibitors Phase 3
21 Adrenergic Agents Phase 3
22 Calcium heparin Phase 3
23 Anticonvulsants Phase 3
24 Anticoagulants Phase 3
25 Adrenergic beta-Antagonists Phase 3
26 diuretics Phase 3
27
Adenosine Approved, Investigational Phase 2 58-61-7 60961
28
Regadenoson Approved, Investigational Phase 2 313348-27-5 22451303 219024
29 Ophthalmic Solutions

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 TENecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): A Randomized Placebo-controlled Trial of Early Systemic Tenecteplase Treatment in Patients With Central Retinal Artery Occlusion. Recruiting NCT04526951 Phase 3 Intravenous injection of Tenecteplase and one dose of placebo tablet;One tablet of Acetylsalicylic Acid and one dose of IV placebo
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 Multizenterstudie Der European Assessment Group for Lysis in the Eye (EAGLE) Zur Behandlung Des Zentralarterienverschlusses (ZAV): Lysetherapie Versus Konservative Therapie Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Unknown status NCT03090087 Phase 2 Regadenoson
6 Early Reperfusion Therapy With Intravenous Alteplase for Recovery of VISION in Acute Central Retinal Artery Occlusion Not yet recruiting NCT04965038 Phase 2 Alteplase
7 Phase 1. Validation and Calibration Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
8 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
9 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
10 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Completed NCT03049514
11 Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study Completed NCT00804102
12 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Completed NCT02898480
13 Hemodynamic Computer-assisted Reconstruction of Pathological Changes at the Origin of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Completed NCT02679716
14 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Completed NCT03753893
15 Evaluation de la gêne Oculaire après Injections intravitréennes Completed NCT02806830 Optive
16 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Completed NCT03357146
17 A Prospective, Multicenter, Blinded Reading, Self Controlled, Superiority Priority Clinical Trial of Assisted Fundus Image Diagnosis Software for the Diagnosis of Multiple Eye Fundus Diseases Completed NCT04723160
18 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Completed NCT02390245
19 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
20 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
21 Safety and Efficacy of the Visual Field Improvement After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion Recruiting NCT05562284
22 Evaluation of the Utility of OCT Angiography in Assessing Vascular Perfusion in Rare Retinal and Choroidal Diseases Recruiting NCT02141308
23 Investigation of Retinal Pathology in Eye Diseases Using High Resolution Optical Coherence Tomography (High-Res-OCT) Not yet recruiting NCT05130385
24 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in the Imaging of Retinovascular Disease Terminated NCT01717937

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

Anatomical Context for Retinal Artery Occlusion

Organs/tissues related to Retinal Artery Occlusion:

MalaCards : Retina, Eye, Brain, Occipital Lobe, Neutrophil, Myeloid, Heart

Publications for Retinal Artery Occlusion

Articles related to Retinal Artery Occlusion:

(show top 50) (show all 2231)
# Title Authors PMID Year
1
Cardiovascular and thrombophilic risk factors in patients with retinal artery occlusion. 53 62
17473572 2007
2
Familial Mediterranean fever associated frosted branch angiitis, retinal vasculitis and vascular occlusion. 62
34725467 2022
3
Perioperative Care of the Patient with Eye Pathologies Undergoing Nonocular Surgery. 62
36179149 2022
4
Outcomes and Readmission in Patients With Retinal Artery Occlusion (from the Nationwide Readmission Database). 62
36115725 2022
5
Central retinal artery occlusion after Moderna mRNA-1273 vaccination. 62
35842300 2022
6
Central retinal artery occlusion and subsequent amaurosis fugax in the contralateral eye associated with the G20210A prothrombin gene (F2) variant: a case report. 62
35570827 2022
7
[On conservative treatment of central retinal artery occlusion]. 62
36098766 2022
8
Central retinal artery occlusion after vaccination with whole virion inactivated SARSCoV- 2 vaccine Covaxin. 62
36190081 2022
9
Central retinal artery occlusion as an ophthalmic complication after snakebite. 62
36088246 2022
10
Combined central retinal artery occlusion and vein occlusion with exudative retinal detachment following COVID-19 vaccination. 62
36098473 2022
11
The Role of Tocilizumab in Glucocorticoid Resistant Giant Cell Arteritis: A Case Series and Literature Review. 62
36166708 2022
12
PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH BRANCH RETINAL ARTERY OCCLUSION DUE TO POLYCYTHEMIA IN A PATIENT WITH TETRALOGY OF FALLOT. 62
32969982 2022
13
Choroidal ischemia as one cardinal sign in giant cell arteritis. 62
36153565 2022
14
[Optical coherence tomography in the differential diagnostics of important neuro-ophthalmological disease patterns]. 62
35994098 2022
15
Ocular adverse events following intravitreal brolucizumab for neovascular age-related macular degeneration at a single tertiary care center. 62
34761684 2022
16
Orbital Compartment Syndrome Following Incisional Biopsy of Orbital Natural Killer/T-Cell Lymphoma. 62
35288498 2022
17
The role of the gut microbiome in eye diseases. 62
36075807 2022
18
PARACENTRAL ACUTE MIDDLE MACULOPATHY AS A PRESENTING SIGN OF CENTRAL RETINAL ARTERY OCCLUSION IN SICKLE CELL DISEASE TREATED WITH TISSUE PLASMINOGEN ACTIVATOR. 62
32618900 2022
19
Systemic thrombolysis for acute central retinal artery occlusion in sickle cell disease: Case report. 62
36163059 2022
20
ANGIOGRAPHIC SMOKESTACK LEAKAGE NOT ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY. 62
32925817 2022
21
Similarities and differences in systemic risk factors for retinal artery occlusion and retinal vein occlusion: A nationwide case-control study. 62
36056288 2022
22
Revascularization Central Retinal Artery Occlusion During Vitrectomy Within 5 Minutes. 62
35342174 2022
23
Retinal and optic nerve magnetic resonance diffusion-weighted imaging in acute non-arteritic central retinal artery occlusion. 62
35849917 2022
24
Combined central retinal vein occlusion with branch retinal artery occlusion in a leukaemic patient with COVID-19. 62
36064204 2022
25
Transient central retina artery occlusion in patients undergoing intravitreal anti vegf injections. 62
34962172 2022
26
Hyper-reflective vitreous spots in central retinal artery occlusion: An unusual finding in two cases. 62
36128764 2022
27
Retinal artery occlusion as an early indicator of macrovascular complications in diabetes. 62
36170938 2022
28
Incomplete Susac's Syndrome: A Case Report and Literature Review. 62
36110471 2022
29
Vaccine-related retinal artery occlusion in adults: a review of the current literature. 62
35953410 2022
30
Central Retinal Artery Occlusion: Can We Effectively Manage This Ocular Emergency in a Hospital Setting? 62
36106224 2022
31
Teaching Video NeuroImage: Amaurosis Fugax Due to Recurrent Central Retinal Artery Occlusion by Microemboli. 62
35750495 2022
32
Central retinal artery occlusion secondary to presumed traumatic carotid artery dissection in a healthy child. 62
35986425 2022
33
Efficacy and safety of intra-arterial thrombolysis in patients with central retinal artery occlusion: a systematic review and meta-analysis. 62
35947182 2022
34
Iatrogenic central retinal artery occlusion following retrobulbar anesthesia with adrenaline for vitreoretinal surgery: a case report. 62
35941712 2022
35
Current diagnosis and treatment practice of central retinal artery occlusion: results from a survey among German stroke units. 62
35909171 2022
36
Lisdexamfetamine (Vyvanse) Use Associated With Branch Retinal Artery Occlusion. 62
36007252 2022
37
Swept-source Optical Coherence Tomography Angiography in Active and Scarred Toxoplasmic Retinochoroiditis. 62
35914295 2022
38
Cerebral angiographic features of central retinal artery occlusion patients treated with intra-arterial thrombolysis. 62
34489353 2022
39
Risk factors for ocular neovascularization after central retinal artery occlusion. 62
35727105 2022
40
Branch retinal artery occlusion in a young patient after radiotherapy for nasopharyngeal carcinoma. 62
36037265 2022
41
Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. 62
36079030 2022
42
Similarities and Differences in Systemic Risk Factors for Retinal Artery Occlusion and Stroke: A Nationwide Case-Control Study. 62
35777081 2022
43
Rhino-orbito-cerebral Mucormycosis: Etiopathology, Clinical Features, Outcome, and the Factors Associated with Outcome. 62
35766047 2022
44
Ocular bartonellosis presenting with focal choroiditis, focal retinitis, branch retinal artery occlusion, and paracentral acute middle maculopathy: longitudinal multimodal imaging analysis. 62
35976627 2022
45
Associations among Stroke, Myocardial Infarction, and Amaurosis Fugax in a Tertiary Referral Hospital in Taiwan. 62
36079019 2022
46
Retinal Infarction: A Pilot Study on the Efficacy and Safety of Intravenous Thrombolysis and Underlying Aetiologies. 62
36013458 2022
47
The Role of Medical Image Modalities and AI in the Early Detection, Diagnosis and Grading of Retinal Diseases: A Survey. 62
36004891 2022
48
Risks of posterior segment ocular ischaemic events in patients with systemic lupus erythematosus: a population-based cohort study in Taiwan. 62
35922126 2022
49
Retinal vein and artery occlusion as the first manifestation of primary antiphospholipid syndrome in a pediatric patient. 62
35857989 2022
50
Management of ocular arterial ischemic diseases: a review. 62
35838806 2022

Variations for Retinal Artery Occlusion

Expression for Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for Retinal Artery Occlusion

Pathways related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1 13.69 ACTA2 F2 FLT1 IL6 PGF PLG
2
Show member pathways
12.92 ACE F2 FLT1 IL6 PGF VEGFB
3
Show member pathways
12.92 VEGFB VEGFA SERPINE1 SERPINC1 PLG F9
4 12.74 VEGFB VEGFA PLG PGF FLT1
5
Show member pathways
12.72 SERPINC1 F9 F8 F5 F2
6
Show member pathways
12.56 VEGFB PGF IL6 IL10 FLT1
7 12.48 VEGFB VEGFA PGF IL6 IL10 FLT1
8
Show member pathways
12.31 VEGFB VEGFA FLT1 ACTA2
9
Show member pathways
12.31 VEGFB VEGFA PGF FLT1 ACTA2
10
Show member pathways
12.28 VEGFB PGF IL6 FLT1 ACTA2
11
Show member pathways
12.2 VEGFB VEGFA PGF FLT1
12
Show member pathways
12.17 SERPINC1 PLG IL6 F5 F2
13 12.16 VEGFB VEGFA PGF FLT1
14
Show member pathways
11.96 SERPINE1 SERPINC1 PLG F9 F8 F5
15 11.81 THY1 IL6 ACTA2
16 11.79 VEGFA IL6 IL10 HMOX1
17 11.77 VEGFB HMOX1 FLT1
18 11.72 VEGFA IL6 IL10 ACTA2
19 11.65 THY1 IL6 IL10
20 11.58 VEGFA SERPINE1 HMOX1
21 11.36 VEGFB VEGFA FLT1
22 11.23 IL6 IL10 HMOX1
23 11.15 VEGFA SERPINE1 FLT1
24 11.12 THY1 PLG IL6
25 10.96 VEGFB VEGFA PGF FLT1
26 10.94 VEGFB PGF IL6 IL10 FLT1
27 10.82 FLT1 SERPINC1 VEGFA
28 10.76 SERPINE1 PLG
29
Show member pathways
10.73 F9 F8
30
Show member pathways
10.57 VEGFB VEGFA
31 10.42 PLG F2
32 10.14 IL10 HMOX1
33
Show member pathways
10.13 VEGFB VEGFA PGF FLT1

GO Terms for Retinal Artery Occlusion

Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.15 ACE APOH F2 F5 F8 F9
2 collagen-containing extracellular matrix GO:0062023 10.1 SERPINE1 SERPINC1 PLG F9 F2 APOH
3 endoplasmic reticulum lumen GO:0005788 10.03 SERPINC1 IL6 F9 F8 F5 F2
4 platelet alpha granule lumen GO:0031093 9.93 F5 F8 PLG SERPINE1 VEGFA VEGFB
5 extracellular space GO:0005615 9.85 ACE ACTA2 APOH F2 F5 F8

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 response to xenobiotic stimulus GO:0009410 10.3 ACE HMOX1 IL10 MTHFR PGF
2 angiogenesis GO:0001525 10.24 FLT1 HMOX1 PGF SERPINE1 THY1 VEGFA
3 positive regulation of endothelial cell proliferation GO:0001938 10.15 VEGFB VEGFA PGF IL10
4 positive regulation of angiogenesis GO:0045766 10.15 FLT1 HMOX1 PGF SERPINE1 VEGFA VEGFB
5 response to hypoxia GO:0001666 10.14 VEGFB VEGFA PGF MTHFR HMOX1 ACE
6 positive regulation of cell division GO:0051781 10.09 VEGFB VEGFA PGF
7 positive chemotaxis GO:0050918 10.08 VEGFB VEGFA PGF
8 acute-phase response GO:0006953 10.07 IL6 F8 F2
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.06 IL6 IL10 F2
10 sprouting angiogenesis GO:0002040 10.05 VEGFB VEGFA PGF
11 liver regeneration GO:0097421 10.03 IL6 IL10 HMOX1
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 10.03 FLT1 PGF VEGFA VEGFB
13 fibrinolysis GO:0042730 10.01 SERPINE1 PLG F2
14 positive regulation of blood coagulation GO:0030194 10 SERPINE1 F2 APOH
15 induction of positive chemotaxis GO:0050930 9.99 VEGFB VEGFA PGF
16 positive regulation of mast cell chemotaxis GO:0060754 9.93 VEGFB VEGFA PGF
17 blood coagulation GO:0007596 9.93 F2 F5 F8 F9 PLG SERPINC1
18 vascular endothelial growth factor signaling pathway GO:0038084 9.92 VEGFB VEGFA PGF FLT1
19 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.87 ACE VEGFA
20 negative regulation of fibrinolysis GO:0051918 9.86 SERPINE1 PLG F2 APOH
21 regulation of blood coagulation GO:0030193 9.78 SERPINC1 F2 APOH
22 regulation of body fluid levels GO:0050878 9.26 F9 F8 F5 F2
23 hemostasis GO:0007599 9.1 SERPINC1 PLG F9 F8 F5 F2

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.93 VEGFB VEGFA SERPINC1 PGF F2 APOH
2 chemoattractant activity GO:0042056 9.8 VEGFB VEGFA PGF
3 vascular endothelial growth factor receptor 1 binding GO:0043183 9.56 VEGFB VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 9.43 VEGFB VEGFA PGF
5 growth factor activity GO:0008083 9.4 VEGFB VEGFA PGF IL6 IL10 F2

Sources for Retinal Artery Occlusion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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