MCID: RTN014
MIFTS: 46

Retinal Artery Occlusion

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Artery Occlusion

MalaCards integrated aliases for Retinal Artery Occlusion:

Name: Retinal Artery Occlusion 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8483
MeSH 44 D015356
NCIt 50 C34978
SNOMED-CT 68 232035005
UMLS 73 C0035302

Summaries for Retinal Artery Occlusion

MalaCards based summary : Retinal Artery Occlusion is related to branch retinal artery occlusion and homocystinuria, and has symptoms including amaurosis fugax An important gene associated with Retinal Artery Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 branch retinal artery occlusion 33.2 APOH F2 MTHFR SERPINC1
2 homocystinuria 30.0 F5 MTHFR SERPINC1
3 arteritic anterior ischemic optic neuropathy 30.0 F2 F5 MTHFR
4 nonarteritic anterior ischemic optic neuropathy 29.9 F2 F5 MTHFR SERPINC1
5 amaurosis fugax 29.9 F5 MTHFR SERPINE1
6 spotted fever 29.9 F2 IL10
7 patent foramen ovale 29.8 F2 F5 MTHFR SERPINC1
8 purpura 29.6 APOH F2 SERPINC1
9 infective endocarditis 29.6 APOH F2 SERPINE1
10 sneddon syndrome 29.4 APOH F2 F5 SERPINC1
11 ischemic optic neuropathy 29.3 APOH F2 F5 MTHFR SERPINC1
12 arteries, anomalies of 29.2 F2 MTHFR SERPINC1 SERPINE1
13 central retinal vein occlusion 29.2 APOH F2 F5 MTHFR SERPINC1
14 coronary artery anomaly 29.1 F5 MTHFR SERPINE1
15 antiphospholipid syndrome 29.1 APOH F2 F5 MTHFR SERPINC1
16 endocarditis 29.0 APOH F2 IL10 SERPINC1
17 protein s deficiency 28.9 APOH F2 F5 MTHFR SERPINC1
18 catastrophic antiphospholipid syndrome 28.9 APOH F5 MTHFR SERPINE1
19 buerger disease 28.8 APOH F2 MTHFR SERPINE1
20 retinal vascular occlusion 28.5 APOH F2 F5 MTHFR SERPINC1
21 retinal vein occlusion 28.3 APOH F2 F5 MTHFR SERPINC1 SERPINE1
22 livedoid vasculopathy 28.3 APOH F2 F5 MTHFR SERPINE1
23 stroke, ischemic 27.9 APOH F2 F5 MTHFR SERPINC1 SERPINE1
24 thrombosis 27.7 APOH F2 F5 MTHFR SERPINC1 SERPINE1
25 thrombophilia 26.7 APOH F2 F5 F8 MTHFR SERPINC1
26 myocardial infarction 26.7 F2 F5 F8 IL10 MTHFR SERPINC1
27 central retinal artery occlusion 12.7
28 transient retinal arterial occlusion 12.4
29 partial arterial retinal occlusion 11.6
30 susac syndrome 11.4
31 retinitis 11.1
32 paracetamol poisoning 10.7 F2 F5
33 may-thurner syndrome 10.6 APOH F5
34 mesenteric vascular occlusion 10.6 F2 MTHFR
35 hemoglobin e disease 10.6 F2 F5
36 acanthamoeba keratitis 10.6 APOH F5
37 pregnancy loss, recurrent 1 10.6 APOH F5
38 ischemic neuropathy 10.6 F2 MTHFR
39 splenic infarction 10.5 APOH F2
40 papilledema 10.5 APOH F2
41 scott syndrome 10.5 F2 F5
42 intestinal impaction 10.5 F2 SERPINC1
43 acquired hemophilia a 10.5 F5 F8
44 leech infestation 10.5 F2 SERPINC1
45 alpha-2-plasmin inhibitor deficiency 10.5 F2 SERPINC1
46 acquired hemophilia 10.5 F5 F8
47 giant hemangioma 10.5 F2 SERPINC1
48 factor v and factor viii, combined deficiency of, 2 10.5 F5 F8
49 intracranial embolism 10.5 F2 SERPINC1
50 acute liver failure 10.4 F2 F5

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to Retinal Artery Occlusion

Symptoms & Phenotypes for Retinal Artery Occlusion

UMLS symptoms related to Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 MTHFR SERPINC1 APOH F2 SERPINE1 F5
2 cardiovascular system MP:0005385 9.8 SERPINC1 F2 SERPINE1 F5 HMOX1 IL10
3 mortality/aging MP:0010768 9.61 MTHFR SERPINC1 APOH F2 SERPINE1 F5
4 liver/biliary system MP:0005370 9.55 SERPINC1 SERPINE1 F5 HMOX1 IL10
5 reproductive system MP:0005389 9.1 MTHFR SERPINC1 F2 F8 HMOX1 IL10

Drugs & Therapeutics for Retinal Artery Occlusion

Drugs for Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
3 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Not Applicable
4 insulin Phase 4
5 Fibrinolytic Agents Phase 4,Phase 3
6 Platelet Aggregation Inhibitors Phase 4,Phase 3
7 Anticoagulants Phase 4,Phase 3
8 Insulin, Globin Zinc Phase 4
9
Warfarin Approved Phase 3 81-81-2 6691 54678486
10
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
11
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
12
Apixaban Approved Phase 3 503612-47-3 10182969
13
Rivaroxaban Approved Phase 3 366789-02-8
14
Acenocoumarol Approved, Investigational Phase 3 152-72-7 9052 54676537
15 Edoxaban Approved Phase 3 480449-70-5
16
Thrombin Approved, Investigational Phase 3
17
Phenindione Approved, Investigational Phase 3 83-12-5 4760
18
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
19
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
20
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
21
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
22
Phytonadione Approved, Investigational, Nutraceutical Phase 3 84-80-0 4812 5284607
23 Dabigatran Phase 3
24 Analgesics Phase 3
25
protease inhibitors Phase 3
26 Serine Proteinase Inhibitors Phase 3
27 Neurotransmitter Agents Phase 3,Phase 2
28 Cyclooxygenase Inhibitors Phase 3
29 Analgesics, Non-Narcotic Phase 3
30 Tissue Plasminogen Activator Phase 3
31 HIV Protease Inhibitors Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Pharmaceutical Solutions Phase 3
34 Vitamins Phase 3
35 Plasminogen Phase 3
36 Factor Xa Inhibitors Phase 3
37 Anti-Inflammatory Agents Phase 3
38 Antipyretics Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 3
40 Antirheumatic Agents Phase 3
41 Antithrombin III Phase 3
42 Antithrombins Phase 3
43 calcium heparin Phase 3
44 diuretics Phase 3
45 Adrenergic Agents Phase 3
46 Adrenergic Antagonists Phase 3
47 Adrenergic beta-Antagonists Phase 3
48 Natriuretic Agents Phase 3
49 Anticonvulsants Phase 3
50 Carbonic Anhydrase Inhibitors Phase 3

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 Study of Antithrombotic Treatment After Intracerebral Haemorrhage Not yet recruiting NCT03186729 Phase 4 Antithrombotic Agent
3 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
4 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
5 Start or STop Anticoagulants Randomised Trial (SoSTART) Recruiting NCT03153150 Phase 3 Apixaban;Rivaroxaban;Edoxaban;Dabigatran;Acenocoumarol;Phenindione;Warfarin
6 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
7 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
8 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
9 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
10 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862 Not Applicable
11 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
12 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
13 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Not Applicable Optive
14 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102 Not Applicable
15 Plaque Prolapse Prevention Carotid Artery Stenting (3PCAS) Completed NCT02665585 Not Applicable
16 Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion Completed NCT01291121 Not Applicable
17 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
18 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
19 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Recruiting NCT03061526
20 OCT in Rare Chorioretinal Diseases Recruiting NCT02141308
21 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
22 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
23 Investigation of Biomarkers in Susac Syndrome Recruiting NCT01273792
24 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Active, not recruiting NCT03357146
25 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Active, not recruiting NCT02679716 Not Applicable
26 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Active, not recruiting NCT02898480 Not Applicable
27 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Active, not recruiting NCT02097134 Not Applicable Melphalan
28 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245 Not Applicable
29 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
30 Objective Assessment of Macular Function at Retinal and Cortical Levels Not yet recruiting NCT03517241
31 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

Anatomical Context for Retinal Artery Occlusion

MalaCards organs/tissues related to Retinal Artery Occlusion:

41
Eye, Retina, Brain, Thyroid, T Cells, Lung

Publications for Retinal Artery Occlusion

Articles related to Retinal Artery Occlusion:

(show top 50) (show all 799)
# Title Authors Year
1
Central Retinal Artery Occlusion with Cilioretinal Artery sparing; imaging by smartphone. ( 29921543 )
2018
2
Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection. ( 29480272 )
2018
3
Central retinal artery occlusion following orbital biopsy. ( 29664557 )
2018
4
RECURRENT BRANCH RETINAL ARTERY OCCLUSION FROM SUSAC SYNDROME: CASE REPORT AND REVIEW OF LITERATURE. ( 29870024 )
2018
5
Calcified amorphous tumor: A rare cause of central retinal artery occlusion. ( 29780907 )
2018
6
Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. ( 29527185 )
2018
7
Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. ( 29739345 )
2018
8
Central retinal artery occlusion secondary to Barlow's disease. ( 29780944 )
2018
9
Central retinal artery occlusion during vitrectomy: Immediate retinal revascularization following induction of posterior vitreous detachment. ( 29468216 )
2018
10
Treatment of Nonarteritic Acute Central Retinal Artery Occlusion. ( 29717825 )
2018
11
Branch retinal artery occlusion as a clinical manifestation of hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) in pregnancy. ( 29068144 )
2018
12
Optic nerve avulsion associated with central retinal artery occlusion following rotational globe injury. ( 29941768 )
2018
13
Clinical presentation of multiple cerebral emboli and central retinal artery occlusion (CRAO) as signs of cardiac myxoma. ( 29942186 )
2018
14
Visibility of Blood Flow on Optical Coherence Tomography Angiography in a Case of Branch Retinal Artery Occlusion. ( 29403595 )
2018
15
Optical Coherence Tomography-Based Angiography in Retinal Artery Occlusion in Children. ( 29393247 )
2018
16
Erratum: Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29763939 )
2018
17
MULTIMODAL IMAGING IN A CASE OF CENTRAL RETINAL ARTERY OCCLUSION IN THE PRESENCE OF TYPE 2 MACULAR TELANGIECTASIA. ( 29905668 )
2018
18
Current treatment of central retinal artery occlusion: a national survey. ( 29236169 )
2018
19
Differentiating Occult Branch Retinal Artery Occlusion from Primary Open-angle Glaucoma. ( 29370018 )
2018
20
Branch retinal artery occlusion post-penetrating globe injury with intraocular foreign body. ( 29283146 )
2018
21
Central Retinal Artery Occlusion with Sparing of Cilioretinal Artery Post Pulmonary Artery Stenting. ( 29607276 )
2018
22
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29378380 )
2018
23
Thrombus in Lamina Cribrosa Seen Using Swept-Source Optical Coherence Tomography in Eye With Central Retinal Artery Occlusion. ( 29360684 )
2018
24
Optical coherence tomography (OCT) angiography of central retinal artery occlusion in the patent cilioretinal artery: a case report. ( 29924197 )
2018
25
Central retinal artery occlusion - rethinking retinal survival time. ( 29669523 )
2018
26
Central retinal arterial occlusion in a patient with pyoderma gangrenosum. ( 29941761 )
2018
27
Ophthalmic artery MRI in an arteritis-related central retinal artery occlusion. ( 29358510 )
2018
28
Intravenous thrombolysis in acute central retinal artery occlusion - A prospective interventional case series. ( 29813111 )
2018
29
Ischemic Stroke Risk in Medicare Beneficiaries with Central Retinal Artery Occlusion: A Retrospective Cohort Study. ( 29574676 )
2018
30
Central retinal artery occlusion showing features of paracentral acute middle maculopathy following uncomplicated pterygium surgery. ( 29962106 )
2018
31
Retinal artery occlusion during carotid artery stenting with distal embolic protection device. ( 29862882 )
2018
32
Management of central retinal artery occlusion following successful hyperbaric oxygen therapy: case report. ( 29571239 )
2018
33
Susac's syndrome: isolated retinal artery occlusion after 10 years of remission. ( 29846415 )
2018
34
Central retinal artery occlusion and traumatic optic neuropathy following blunt ocular trauma. ( 29862194 )
2018
35
Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion. ( 29358594 )
2018
36
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
37
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
38
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
39
Fundus autofluorescence in retinal artery occlusion: A more precise diagnosis. ( 28882392 )
2017
40
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
41
Combined Central Retinal Vein and Branch Retinal Artery Occlusion Post Intense Physical Activity. ( 29067224 )
2017
42
Bilateral Central Retinal Artery Occlusion Associated with Bilateral Lymphoproliferative Infiltrative Optic Neuropathy. ( 29071274 )
2017
43
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017
44
Transient central retinal artery occlusion following viperine snake bite. ( 29217042 )
2017
45
Carotid cavernous fistula with central retinal artery occlusion and Terson syndrome after mid-facial trauma. ( 28580223 )
2017
46
Combined branch retinal vein and branch retinal artery occlusion - clinical features, systemic associations, and outcomes. ( 28440254 )
2017
47
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
48
The efficacy of hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 28500127 )
2017
49
Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid. ( 28705840 )
2017
50
Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study. ( 28228436 )
2017

Variations for Retinal Artery Occlusion

Expression for Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for Retinal Artery Occlusion

GO Terms for Retinal Artery Occlusion

Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 APOH F2 F5 F8 IL10 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.46 F2 F5 F8 SERPINC1
3 COPII-coated ER to Golgi transport vesicle GO:0030134 9.32 F5 F8
4 extracellular space GO:0005615 9.23 APOH F2 F5 F8 HMOX1 IL10
5 platelet alpha granule lumen GO:0031093 9.13 F5 F8 SERPINE1

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 F2 F5 F8 SERPINC1
2 cellular protein metabolic process GO:0044267 9.67 F2 F5 SERPINC1
3 platelet degranulation GO:0002576 9.67 APOH F5 F8 SERPINE1
4 ER to Golgi vesicle-mediated transport GO:0006888 9.65 F2 F5 F8
5 blood circulation GO:0008015 9.57 F5 MTHFR
6 acute-phase response GO:0006953 9.56 F2 F8
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL10 SERPINE1
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.54 HMOX1 SERPINE1
9 liver regeneration GO:0097421 9.52 HMOX1 IL10
10 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.51 HMOX1 IL10
11 blood coagulation, intrinsic pathway GO:0007597 9.5 APOH F2 F8
12 fibrinolysis GO:0042730 9.46 F2 SERPINE1
13 negative regulation of blood coagulation GO:0030195 9.43 APOH SERPINE1
14 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
15 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
16 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
17 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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