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MCID: RTN015
MIFTS: 49

Retinal Cancer

Categories: Cancer diseases, Eye diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Retinal Cancer

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MalaCards integrated aliases for Retinal Cancer:

Name: Retinal Cancer 12 15 17
Malignant Neoplasm of Retina 12 71
Retinal Neoplasms 43 71
Malignant Retinal Neoplasm 12
Malignant Tumor of Retina 12
Neoplasm of Retina 12
Retinal Neoplasm 17
Retinal Tumor 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4645
ICD9CM 34 190.5
MeSH 43 D019572
NCIt 49 C3216 C4800
SNOMED-CT 67 93987004
ICD10 32 C69.2
UMLS 71 C0024622 C0524801
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Summaries for Retinal Cancer

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MalaCards based summary : Retinal Cancer, also known as malignant neoplasm of retina, is related to retinoblastoma and familial retinoblastoma. An important gene associated with Retinal Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ERK Signaling and Cell Cycle, Mitotic. The drugs Etoposide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,... more...

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Related Diseases for Retinal Cancer

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Diseases related to Retinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 retinoblastoma 32.9 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2 familial retinoblastoma 30.5 TP53 RBL1 RB1 E2F4 CDKN2A CDK4
3 thymoma 30.4 TP53 MIR125A CDKN2A CCND1
4 retinal vascular disease 30.4 MIR199A1 H2AC18 CRYAA
5 osteogenic sarcoma 30.3 TP53 RB1 E2F4 E2F1 CDKN2A CDK4
6 vulvar adenocarcinoma 10.8 TP53 RB1
7 esophageal leukoplakia 10.8 TP53 CCND1
8 urinary bladder inverted papilloma 10.8 RB1 CDKN2A
9 ring chromosome 7 10.8 TP53 CDK4
10 mediastinum liposarcoma 10.8 CDKN2A CDK4
11 cecal benign neoplasm 10.8 RBL1 CDKN2A CDK2
12 cecum adenoma 10.8 RBL1 CDKN2A CDK2
13 suppressor of tumorigenicity 3 10.8 TP53 RB1 CDKN2A
14 esophagus verrucous carcinoma 10.8 TP53 CDKN2A CCND1
15 anal squamous cell carcinoma 10.8 TP53 H2AC18 CDKN2A APC
16 connective tissue benign neoplasm 10.8 TP53 CDK4 APC
17 anus cancer 10.8 TP53 H2AC18 CDKN2A
18 ischemic fasciitis 10.7 CDKN2A CDK4 CCND1
19 hyperplastic polyposis syndrome 10.7 TP53 APC
20 uterus carcinoma in situ 10.7 TP53 RB1 CDKN2A
21 cervix uteri carcinoma in situ 10.7 TP53 RB1 CDKN2A
22 bone squamous cell carcinoma 10.7 TP53 CDKN2A CCND1
23 lymphatic system cancer 10.7 TP53 MIR17 KDM4C H2AC18
24 dedifferentiated liposarcoma 10.7 TP53 RB1 CDKN2A CDK4
25 cll/sll 10.7 TP53 KDM4C CCND1
26 anogenital venereal wart 10.7 TP53 RB1 H2AC18 CDKN2A
27 laryngeal benign neoplasm 10.7 TP53 CDKN2A CCND1
28 fibrillary astrocytoma 10.7 TP53 KDM4C H2AC18 CDKN2A
29 pancreatic foamy gland adenocarcinoma 10.7 TP53 CCND1
30 herpangina 10.7 TP53 H2AC18 CDKN2A
31 pleural cancer 10.7 TP53 MIR17 H2AC18 CDKN2A
32 vulvar intraepithelial neoplasia 10.7 TP53 CDKN2A
33 central nervous system benign neoplasm 10.7 TP53 KDM4C H2AC18
34 inverted papilloma 10.7 TP53 CDKN2A CCND1
35 skeletal muscle cancer 10.7 TP53 MIR675 MIR199A1 H2AC18
36 nodular malignant melanoma 10.7 TP53 CDKN2A CDK4 CCND1
37 adenoma 10.7 TP53 CDKN2A CCND1 APC
38 soft palate cancer 10.7 E2F4 E2F1 CDKN2A
39 respiratory system benign neoplasm 10.7 TP53 H2AC18 CDKN2A CCND1
40 fetal alcohol spectrum disorder 10.7 MIR9-1 KDM4C H2AC18
41 gliomatosis cerebri 10.7 TP53 RB1 KDM4C CDKN2A
42 penile disease 10.7 TP53 RB1 CDKN2A
43 lung adenoma 10.7 TP53 H2AC18 CDKN2A CDK2
44 uterine corpus cancer 10.7 TP53 H2AC18 CDKN2A
45 endocrine organ benign neoplasm 10.7 TP53 MIR199A1 MIR17 H2AC18
46 anus disease 10.7 TP53 H2AC18 CDKN2A
47 thymus gland disease 10.7 TP53 MIR125A H2AC18
48 tonsil cancer 10.7 TP53 MIR199A1 H2AC18 CDKN2A
49 testicular disease 10.7 TP53 MIR199A1 KDM4C H2AC18
50 colonic benign neoplasm 10.7 TP53 KDM4C H2AC18 CCND1 APC

Graphical network of the top 20 diseases related to Retinal Cancer:



Diseases related to Retinal Cancer
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Symptoms & Phenotypes for Retinal Cancer

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GenomeRNAi Phenotypes related to Retinal Cancer according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.26 KDM4C RB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.26 RB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.26 CCND1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.26 APC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.26 KDM4C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.26 CDK6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-144 10.26 CDK6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.26 RB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.26 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.26 CCND1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.26 CDK6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.26 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.26 CDK6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.26 APC CCND1 CDK6 KDM4C RB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.26 RB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.26 KDM4C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-191 10.26 KDM4C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.26 APC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.26 CCND1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.26 APC
21 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.26 CCND1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.26 CCND1 RB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.26 CCND1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.26 CCND1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.26 APC CDK6
26 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.26 CCND1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.26 RB1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.26 APC
29 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.26 RB1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.26 CDK6
31 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.26 RB1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.26 APC
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.26 CDK6
34 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 9.02 APC CDK2 CDK4 CDK6 RBL1

MGI Mouse Phenotypes related to Retinal Cancer:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
2 cardiovascular system MP:0005385 10.31 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
3 endocrine/exocrine gland MP:0005379 10.29 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
4 growth/size/body region MP:0005378 10.27 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
5 hematopoietic system MP:0005397 10.23 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
6 embryo MP:0005380 10.22 APC CDK2 CDK4 CDK6 CDKN2A E2F1
7 immune system MP:0005387 10.21 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
8 digestive/alimentary MP:0005381 10.19 APC CCND1 CDK4 CDKN2A E2F1 E2F4
9 craniofacial MP:0005382 10.15 APC CCND1 CDK4 E2F1 E2F4 RB1
10 integument MP:0010771 10.14 APC CCND1 CDK2 CDK4 CDKN2A E2F1
11 neoplasm MP:0002006 10.03 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
12 liver/biliary system MP:0005370 9.97 APC CDK2 CDK4 CDK6 CDKN2A RB1
13 muscle MP:0005369 9.97 APC CDK2 CDK4 CDK6 CDKN2A E2F1
14 hearing/vestibular/ear MP:0005377 9.95 APC E2F1 E2F4 RB1 RBL1 TP53
15 reproductive system MP:0005389 9.7 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
16 pigmentation MP:0001186 9.55 APC CDK4 CDKN2A RB1 TP53
17 vision/eye MP:0005391 9.32 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
Sources

Drugs & Therapeutics for Retinal Cancer

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Drugs for Retinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
7
Lenograstim Approved, Investigational Phase 3 135968-09-1
8
Mesna Approved, Investigational Phase 3 3375-50-6 598
9 Immunologic Factors Phase 3
10 Alkylating Agents Phase 3
11 Topoisomerase Inhibitors Phase 3
12 Antimitotic Agents Phase 3
13 Immunosuppressive Agents Phase 3
14 Etoposide phosphate Phase 3
15 topoisomerase I inhibitors Phase 3
16 Anti-Bacterial Agents Phase 3
17 Anesthetics Phase 3
18 Antibiotics, Antitubercular Phase 3
19
Liposomal doxorubicin Phase 3 31703
20 Antirheumatic Agents Phase 3
21
Melphalan Approved Phase 2 148-82-3 4053 460612

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma Unknown status NCT00179920 Phase 2 Carboplatin;VP-16
3 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)
4 Use of Eylea for the Treatment of an Optic Nerve Hemangioma No longer available NCT01714115 Aflibercept

Search NIH Clinical Center for Retinal Cancer

Cochrane evidence based reviews: retinal neoplasms

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Genetic Tests for Retinal Cancer

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Anatomical Context for Retinal Cancer

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MalaCards organs/tissues related to Retinal Cancer:

40
Retina, Eye, Breast, Lung, Bone, B Cells, Brain
Sources

Publications for Retinal Cancer

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Articles related to Retinal Cancer:

(show all 15)
# Title Authors PMID Year
1
Comprehensive characterization of a Canadian cohort of von Hippel-Lindau disease patients. 61
31368132 2019
2
Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. 61
24911651 2014
3
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. 61
23498719 2013
4
Maintenance of retinal cancer stem cell-like properties through long-term serum-free culture from human retinoblastoma. 61
21573498 2011
5
Vascular Recruitment of Human Retinoblastoma Cells by Multi-Cellular Adhesive Interactions with Circulating Leukocytes. 61
25110524 2010
6
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. 61
20335444 2010
7
Are patients with down syndrome predisposed to retinal neoplasms? 61
19941422 2009
8
Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex. 61
15747752 2004
9
Cancer-associated retinopathy during treatment for small-cell lung carcinoma. 61
10435368 1999
10
Developmental basis of retinal-specific induction of cancer by RB mutation. 61
10197588 1999
11
Ocular manifestations of various systemic disorders. 61
10150822 1994
12
Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. 61
8392328 1993
13
Management and monitoring of cancer-associated retinopathy. 61
1310001 1992
14
Retinal tumor induction by ocular inoculation of human adneovirus in 3-day-old rats. 61
1117320 1975
15
[Bilateral retinal cancer in 2 female twins]. 61
5383904 1969
Sources

Variations for Retinal Cancer

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Cosmic variations for Retinal Cancer:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM86647435 RB1 eye,retina,retinoblastoma,NS c.2106+2T>G p.? 13:48459835-48459835 3
2 COSM86634466 RB1 eye,retina,retinoblastoma,NS c.380+1G>T p.? 13:48342715-48342715 3
3 COSM86624550 RB1 eye,retina,retinoblastoma,NS c.1333C>T p.R445* 13:48379594-48379594 3
4 COSM86651352 RB1 eye,retina,retinoblastoma,NS c.1421G>A p.S474N 13:48380084-48380084 3
5 COSM86624126 RB1 eye,retina,retinoblastoma,NS c.751C>T p.R251* 13:48362847-48362847 3
6 COSM86624950 RB1 eye,retina,retinoblastoma,NS c.1183C>T p.Q395* 13:48373460-48373460 3
7 COSM86626226 RB1 eye,retina,retinoblastoma,NS c.958C>T p.R320* 13:48367512-48367512 3
8 COSM86647609 RB1 eye,retina,retinoblastoma,NS c.1960+2T>C p.? 13:48456351-48456351 3
9 COSM86625405 RB1 eye,retina,retinoblastoma,NS c.1666C>T p.R556* 13:48381414-48381414 3
10 COSM86626205 RB1 eye,retina,retinoblastoma,NS c.1363C>T p.R455* 13:48379624-48379624 3
11 COSM86628490 RB1 eye,retina,retinoblastoma,NS c.763C>T p.R255* 13:48362859-48362859 3
12 COSM86642443 RB1 eye,retina,retinoblastoma,NS c.2527G>T p.E843* 13:48476707-48476707 3
13 COSM86636835 RB1 eye,retina,retinoblastoma,NS c.2326-2A>C p.? 13:48465203-48465203 3
14 COSM86633737 RB1 eye,retina,retinoblastoma,NS c.967G>T p.E323* 13:48367521-48367521 3
15 COSM86624252 RB1 eye,retina,retinoblastoma,NS c.1215+1G>A p.? 13:48373493-48373493 3
16 COSM86631349 RB1 eye,retina,retinoblastoma,NS c.2158A>T p.K720* 13:48463782-48463782 3
17 COSM86627680 RB1 eye,retina,retinoblastoma,NS c.1166T>A p.L389* 13:48373443-48373443 3
18 COSM86638492 RB1 eye,retina,retinoblastoma,NS c.1216-2A>G p.? 13:48376916-48376916 3
19 COSM86629052 RB1 eye,retina,retinoblastoma,NS c.1961-1G>A p.? 13:48459687-48459687 3
20 COSM86640644 RB1 eye,retina,retinoblastoma,NS c.1467C>A p.C489* 13:48380210-48380210 3
21 COSM86635450 RB1 eye,retina,retinoblastoma,NS c.2053C>T p.Q685* 13:48459780-48459780 3
22 COSM86637950 RB1 eye,retina,retinoblastoma,NS c.265-2A>C p.? 13:48342597-48342597 3
23 COSM86629160 RB1 eye,retina,retinoblastoma,NS c.409G>T p.E137* 13:48345108-48345108 3
24 COSM86624395 RB1 eye,retina,retinoblastoma,NS c.2520+4A>G p.? 13:48473394-48473394 3
25 COSM86640590 RB1 eye,retina,retinoblastoma,NS c.1891C>T p.Q631* 13:48456280-48456280 3
26 COSM86656361 RB1 eye,retina,retinoblastoma,NS c.982A>C p.N328H 13:48367536-48367536 3
27 COSM86630951 RB1 eye,retina,retinoblastoma,NS c.1654C>T p.R552* 13:48381402-48381402 3
28 COSM86631559 RB1 eye,retina,retinoblastoma,NS c.1049+1G>T p.? 13:48367604-48367604 3
29 COSM86632900 RB1 eye,retina,retinoblastoma,NS c.2063T>C p.L688P 13:48459790-48459790 3
30 COSM86649095 RB1 eye,retina,retinoblastoma,NS c.2106+1G>T p.? 13:48459834-48459834 3
31 COSM86626876 RB1 eye,retina,retinoblastoma,NS c.2206C>T p.Q736* 13:48463830-48463830 3
32 COSM86637333 RB1 eye,retina,retinoblastoma,NS c.341C>A p.S114* 13:48342675-48342675 3
33 COSM86632739 RB1 eye,retina,retinoblastoma,NS c.1960+1G>A p.? 13:48456350-48456350 3
34 COSM86630352 RB1 eye,retina,retinoblastoma,NS c.862-5T>G p.? 13:48364889-48364889 3
35 COSM86632080 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
36 COSM86654450 RB1 eye,retina,retinoblastoma,NS c.2152G>A p.D718N 13:48463776-48463776 3
37 COSM86640621 RB1 eye,retina,retinoblastoma,NS c.1389+1G>C p.? 13:48379651-48379651 3
38 COSM86648958 RB1 eye,retina,retinoblastoma,NS c.1494T>A p.Y498* 13:48380237-48380237 3
39 COSM87132285 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
40 COSM87804005 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
41 COSM87804055 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
42 COSM91859716 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
43 COSM134990158 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
44 COSM134614922 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
45 COSM134990112 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
46 COSM148932691 eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
47 COSM134614978 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
48 COSM150688162 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
49 COSM91859752 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
Sources

Expression for Retinal Cancer

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Search GEO for disease gene expression data for Retinal Cancer.
Sources

Pathways for Retinal Cancer

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Pathways related to Retinal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.91 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2
Cell Cycle, Mitotic 65
Show member pathways
 13.55 TP53 RBL1 RB1 H2AC18 E2F4 E2F1
3
Cellular Senescence (REACTOME) 65
Show member pathways
 13.23 TP53 RB1 H2AC18 E2F1 CDKN2A CDK6
4
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.19 TP53 RB1 E2F1 CDK6 CDK4 CDK2
5
PI3K-Akt signaling pathway 36
Show member pathways
 13.12 TP53 RBL1 RB1 E2F1 CDK6 CDK4
6
Human cytomegalovirus infection 36
Show member pathways
 13.03 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
7
Aldosterone synthesis and secretion 36
Show member pathways
 13.03 RB1 E2F1 CDKN2A CDK6 CDK4 CDK2
8
Regulation of TP53 Activity 65
Show member pathways
 13.02 TP53 RBL1 E2F4 E2F1 CDKN2A CDK2
9
Endometrial cancer 36
Show member pathways
 13 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
10
Pathways in cancer 36
12.97 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
11
Measles 36
Show member pathways
 12.93 TP53 RB1 E2F1 CDK6 CDK4 CDK2
12
Gastric cancer 36
Show member pathways
 12.87 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
13
Chks in Checkpoint Regulation 63
Show member pathways
 12.84 TP53 RBL1 RB1 E2F4 E2F1 CDK4
14
Glioma 36
Show member pathways
 12.81 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
15
DREAM Repression and Dynorphin Expression 63
Show member pathways
 12.72 RB1 CDK6 CDK4 CDK2 CCND1
16
Mitotic G1-G1/S phases 65
Show member pathways
 12.65 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
17
DNA Damage 4
12.63 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
18
MicroRNAs in cancer 36
12.59 TP53 MIR9-1 MIR199A1 MIR17 MIR125A E2F1
19
Human T-cell leukemia virus 1 infection 36
12.49 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
20
DNA Damage Response 1
Show member pathways
 12.48 TP53 RB1 MIR17 E2F1 CDKN2A CDK6
21
WNT Signaling 63
12.47 TP53 RBL1 RB1 E2F4 E2F1 CDK6
22
Viral carcinogenesis 36
12.43 TP53 RBL1 RB1 CDKN2A CDK6 CDK4
23
p53 Signaling 63
Show member pathways
 12.4 TP53 RB1 E2F4 E2F1 CDK4 CDK2
24
DNA Damage/Telomere Stress Induced Senescence 65
Show member pathways
 12.38 TP53 RB1 H2AC18 CDK2
25
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.37 TP53 RB1 E2F4 E2F1 CDK4 CDK2
26
Cyclins and Cell Cycle Regulation 63
Show member pathways
 12.37 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
27
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.36 RB1 E2F4 E2F1 CDKN2A CDK6 CDK4
28
Integrated Breast Cancer Pathway 1
12.3 TP53 RB1 E2F1 CDK4 CDK2 CCND1
29
Colorectal Cancer Metastasis 63
12.24 TP53 E2F4 CCND1 APC
30
Spinal Cord Injury 1
12.18 TP53 RB1 E2F1 CDK4 CDK2 CCND1
31
TGF-beta Signaling Pathway (WikiPathways) 1
12.14 TP53 RBL1 E2F4 CCND1
32
Adipogenesis 1
12.13 RBL1 RB1 E2F4 E2F1
33
DNA Damage Response (only ATM dependent) 1
12.07 TP53 CDKN2A CCND1 APC
34
TP53 Regulates Transcription of Cell Cycle Genes 65
Show member pathways
 12.07 TP53 RBL1 E2F4 E2F1 CDK2
35
Senescence and Autophagy in Cancer 1
12.03 TP53 RB1 E2F1 CDKN2A
36
Small cell lung cancer 36
12 TP53 RB1 E2F1 CDK6 CDK4 CDK2
37
Retinoblastoma (RB) in Cancer 1
11.97 TP53 RB1 E2F1 CDK6 CDK4 CDK2
38
BRCA1 Pathway 63
Show member pathways
 11.92 TP53 RB1 E2F4 E2F1
39
E2F transcription factor network 1
11.92 RBL1 RB1 E2F4 E2F1 CDK2
40
Glioblastoma Multiforme 63
11.9 TP53 RB1 E2F4 E2F1 CDKN2A CDK6
41
Bladder cancer 36 1
11.88 TP53 RB1 E2F1 CDKN2A CDK4 CCND1
42
Cellular senescence (KEGG) 36
11.86 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
43
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.82 RB1 E2F1 CDK4 CDK2
44
Transcription_P53 signaling pathway 22
11.82 TP53 RB1 E2F1 CDKN2A CDK2
45
Regulation of nuclear SMAD2/3 signaling 1
11.8 RBL1 CDK4 CDK2
46
Cell cycle Cell cycle (generic schema) 22
Show member pathways
 11.79 RBL1 RB1 E2F4 E2F1 CDK6 CDK4
47
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.77 TP53 CDKN2A CDK2
48
Cell cycle 1 36
11.72 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
49
Photodynamic therapy-induced AP-1 survival signaling. 1
11.69 TP53 RB1 CDKN2A CCND1
50
miRNAs involved in DNA damage response 1
11.68 TP53 E2F1 CDK6 CCND1
Sources

GO Terms for Retinal Cancer

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Cellular components related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.2 TP53 RBL1 RB1 MIR9-1 KDM4C H2AC18
2 nucleoplasm GO:0005654 9.97 TP53 RBL1 RB1 KDM4C E2F4 E2F1
3 Rb-E2F complex GO:0035189 9.26 RB1 E2F1
4 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.26 CDK6 CDK4 CDK2 CCND1
5 transcription factor complex GO:0005667 9.17 TP53 RBL1 RB1 E2F4 E2F1 CDK4

Biological processes related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.08 TP53 RBL1 RB1 E2F4 E2F1 CDK6
2 positive regulation of gene expression GO:0010628 10.01 TP53 MIR125A KDM4C E2F1 CDKN2A CDK6
3 cell division GO:0051301 10 RB1 CDK6 CDK4 CDK2 CCND1
4 negative regulation of cell proliferation GO:0008285 10 TP53 RB1 MIR9-1 CDKN2A CDK6 APC
5 positive regulation of apoptotic process GO:0043065 9.99 TP53 E2F1 CDKN2A CDK4 APC
6 negative regulation of gene expression GO:0010629 9.95 TP53 RBL1 RB1 MIR17 MIR125A
7 regulation of cell proliferation GO:0042127 9.91 TP53 E2F4 CDK6 CDK4
8 gene silencing by miRNA GO:0035195 9.85 MIR9-1 MIR675 MIR199A1 MIR17 MIR125A MIR106A
9 Ras protein signal transduction GO:0007265 9.8 TP53 RB1 CDKN2A CDK2
10 cell cycle arrest GO:0007050 9.8 TP53 RB1 CDKN2A CDK6 APC
11 negative regulation of osteoblast differentiation GO:0045668 9.76 MIR9-1 MIR675 CDK6
12 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.76 TP53 E2F4 E2F1 CDK2
13 positive regulation of fibroblast proliferation GO:0048146 9.73 MIR17 E2F1 CDK6 CDK4
14 negative regulation of cellular senescence GO:2000773 9.69 RBL1 MIR17 CDK6
15 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.65 RBL1 RB1 CDKN2A CDK6 CDK4
16 cell cycle GO:0007049 9.65 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
17 replicative senescence GO:0090399 9.63 TP53 CDKN2A
18 G1/S transition of mitotic cell cycle GO:0000082 9.63 RB1 CDKN2A CDK6 CDK4 CDK2 CCND1
19 hematopoietic stem cell differentiation GO:0060218 9.62 TP53 CDK6
20 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR199A1 MIR17
21 cellular response to xenobiotic stimulus GO:0071466 9.6 RB1 E2F1
22 re-entry into mitotic cell cycle GO:0000320 9.58 MIR199A1 CCND1
23 regulation of lipid kinase activity GO:0043550 9.57 RBL1 RB1
24 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.56 RB1 E2F1
25 mitotic G1 DNA damage checkpoint GO:0031571 9.5 TP53 CDK2 CCND1
26 regulation of cell cycle GO:0051726 9.23 TP53 RBL1 RB1 E2F4 E2F1 CDK4

Molecular functions related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.83 TP53 E2F1 CDKN2A CCND1 APC
2 RNA polymerase II activating transcription factor binding GO:0001102 9.58 TP53 RBL1 RB1
3 promoter-specific chromatin binding GO:1990841 9.54 TP53 RBL1 E2F4
4 disordered domain specific binding GO:0097718 9.5 TP53 RB1 CDKN2A
5 RNA polymerase II regulatory region DNA binding GO:0001012 9.46 RBL1 RB1
6 cyclin binding GO:0030332 9.43 CDK6 CDK4 CDK2
7 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.43 MIR9-1 MIR675 MIR199A1 MIR17 MIR125A MIR106A
8 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.33 CDK6 CDK4 CDK2
9 transcription factor binding GO:0008134 9.17 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
Sources

Sources for Retinal Cancer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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