Retinal Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Retinal Cancer, also known as malignant neoplasm of retina, is related to retinoblastoma and retinal disease. An important gene associated with Retinal Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and brain, and related phenotypes are neoplasm and endocrine/exocrine gland

Wikipedia: ⁷⁵ Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,... more...

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Related Diseases for Retinal Cancer

Diseases related to Retinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)

#	Related Disease	Score	Top Affiliating Genes
1	retinoblastoma	32.2	TP53 RBL1 RB1 MIR34A E2F1 CDKN2A
2	retinal disease	31.9	TP53 RBL1 RB1 MIR9-1 MIR675 MIR361
3	retinitis pigmentosa	30.4	TP53 MIR9-1 MIR21 MIR17 MIR125A KDM4C
4	retinal vascular disease	30.3	MIR21 MIR20A MIR199A1 MIR17 H2AC18
5	osteogenic sarcoma	30.2	TP53 RBL1 RB1 MIR199A1 E2F1 CDKN2A
6	melanoma, uveal	30.2	TP53 MIR9-1 MIR199A1 MIR17 MIR125A KDM4C
7	vasoproliferative tumor of the retina	10.9
8	cystadenocarcinoma	10.6	TP53 MIR21 MIR199A1
9	urinary bladder inverted papilloma	10.5	RB1 CDKN2A
10	extrinsic cardiomyopathy	10.5	MIR21 MIR199A1 MIR17 H2AC18
11	verrucous carcinoma	10.5	TP53 MIR125A CDKN2A
12	adenoma	10.5	TP53 CDKN2A CCND1 APC
13	suppressor of tumorigenicity 3	10.5	TP53 RB1 CDKN2A
14	anal squamous cell carcinoma	10.5	TP53 H2AC18 CDKN2A
15	cardiovascular organ benign neoplasm	10.5	TP53 MIR199A1 MIR17 H2AC18 APC
16	esophagus verrucous carcinoma	10.5	TP53 CDKN2A CCND1
17	testicular disease	10.5	TP53 MIR199A1 KDM4C H2AC18
18	intrahepatic cholangiocarcinoma	10.5	TP53 MIR199A1 MIR17 KDM4C H2AC18
19	diffuse astrocytoma	10.5	TP53 KDM4C H2AC18 CDKN2A
20	bilateral retinoblastoma	10.5	TP53 RBL1 RB1 E2F1
21	anus cancer	10.5	TP53 RB1 H2AC18 CDKN2A
22	rhabdoid cancer	10.5	TP53 MIR9-1 KDM4C H2AC18
23	anogenital venereal wart	10.5	TP53 RB1 H2AC18 CDKN2A
24	glioma	10.5	TP53 MIR34A MIR21 MIR20A MIR17
25	hereditary melanoma	10.5	CDKN2A CDK4
26	bone remodeling disease	10.5	MIR675 MIR199A1 MIR17 H2AC18
27	intrinsic cardiomyopathy	10.5	MIR21 MIR199A1 MIR17 H2AC18
28	mediastinum liposarcoma	10.5	CDKN2A CDK4
29	ovarian cystadenocarcinoma	10.5	TP53 MIR17 H2AC18 CDKN2A
30	estrogen-receptor negative breast cancer	10.5	TP53 H2AC18 CCND1
31	myxofibrosarcoma	10.5	TP53 H2AC18 CDKN2A CDK4
32	peritoneum cancer	10.5	TP53 H2AC18 CDKN2A
33	bone resorption disease	10.5	MIR675 MIR199A1 MIR17 MIR125A H2AC18
34	childhood medulloblastoma	10.5	TP53 KDM4C H2AC18
35	ovarian clear cell carcinoma	10.5	TP53 MIR9-1 MIR21 MIR199A1 H2AC18
36	uterus carcinoma in situ	10.5	TP53 RB1 CDKN2A
37	cervix uteri carcinoma in situ	10.5	TP53 RB1 CDKN2A
38	connective tissue benign neoplasm	10.5	TP53 H2AC18 CDK4
39	germ cell and embryonal cancer	10.5	TP53 MIR9-1 KDM4C H2AC18
40	ovary adenocarcinoma	10.5	TP53 MIR17 H2AC18 CDKN2A
41	mature t-cell and nk-cell lymphoma	10.5	TP53 MIR21 MIR199A1 MIR17 KDM4C H2AC18
42	primary cutaneous t-cell non-hodgkin lymphoma	10.5	MIR34A MIR21 MIR17 KDM4C H2AC18
43	colorectal adenocarcinoma	10.5	TP53 MIR17 H2AC18 CCND1
44	cholangiocarcinoma	10.5	TP53 MIR21 CDKN2A CCND1
45	aortic valve disease 2	10.5	MIR34A MIR21 MIR199A1 MIR17 H2AC18
46	lung adenoma	10.5	TP53 H2AC18 CDKN2A CCND1
47	autoimmune disease of skin and connective tissue	10.5	MIR21 MIR20A MIR17 H2AC18
48	nodular malignant melanoma	10.5	TP53 CDKN2A CDK4 CCND1
49	acute erythroid leukemia	10.5	TP53 KDM4C H2AC18
50	supratentorial cancer	10.5	TP53 H2AC18 CDKN2A

Graphical network of the top 20 diseases related to Retinal Cancer:

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Symptoms & Phenotypes for Retinal Cancer

MGI Mouse Phenotypes related to Retinal Cancer:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	10.24	APC CCND1 CDK2 CDK4 CDKN2A E2F1
2	endocrine/exocrine gland	MP:0005379	10.17	APC CCND1 CDK2 CDK4 CDKN2A E2F1
3	immune system	MP:0005387	10.1	APC CCND1 CDK2 CDK4 CDKN2A E2F1
4	no phenotypic analysis	MP:0003012	10.08	CDKN2A KDM4C MIR199A1 MIR34A MIR9-1 RB1
5	muscle	MP:0005369	10.06	APC CDK2 CDK4 CDKN2A E2F1 RB1
6	digestive/alimentary	MP:0005381	10.01	APC CCND1 CDK4 CDKN2A E2F1 RB1
7	pigmentation	MP:0001186	9.99	APC CDK4 CDKN2A E2F1 RB1 TP53
8	reproductive system	MP:0005389	9.96	APC CCND1 CDK2 CDK4 CDKN2A E2F1
9	craniofacial	MP:0005382	9.91	APC CCND1 CDK4 E2F1 RB1 RBL1
10	vision/eye	MP:0005391	9.85	APC CCND1 CDK2 CDK4 CDKN2A E2F1
11	hematopoietic system	MP:0005397	9.73	APC CCND1 CDK2 CDK4 CDKN2A E2F1
12	integument	MP:0010771	9.36	APC CCND1 CDK2 CDK4 CDKN2A E2F1

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Drugs & Therapeutics for Retinal Cancer

Drugs for Retinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904

2

Etoposide

Approved

Phase 3

33419-42-0

36462

3

Lenograstim

Approved, Investigational

Phase 3

135968-09-1

4

Topotecan

Approved, Investigational

Phase 3

123948-87-8, 119413-54-6

60699 60700

5

Cyclophosphamide

Approved, Investigational

Phase 3

50-18-0, 6055-19-2

2907

6

Coenzyme M

Approved, Investigational

Phase 3

3375-50-6

598 23662354

7

Vincristine

Approved, Investigational

Phase 3

2068-78-2, 57-22-7

5978

8

Doxorubicin

Approved, Investigational

Phase 3

23214-92-8

31703

9

Etoposide phosphate

Phase 3

16760419

10

Antirheumatic Agents

Phase 3

11

Anti-Bacterial Agents

Phase 3

12

Alkylating Agents

Phase 3

13

Antineoplastic Agents, Alkylating

Phase 3

14

Antimitotic Agents

Phase 3

15

topoisomerase I inhibitors

Phase 3

16

Tubulin Modulators

Phase 3

17

Anesthetics

Phase 3

18

Antibiotics, Antitubercular

Phase 3

19

Liposomal doxorubicin

Phase 3

20

Immunosuppressive Agents

Phase 3

21

Immunologic Factors

Phase 3

22

Melphalan

Approved

Phase 2

148-82-3

4053 460612

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma	Active, not recruiting	NCT00186888	Phase 3	Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2	Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma	Completed	NCT00179920	Phase 2	Carboplatin;VP-16
3	Conservative Treatments of Retinoblastoma	Recruiting	NCT02866136	Phase 2	VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)

Search NIH Clinical Center for Retinal Cancer

Cochrane evidence based reviews: retinal neoplasms

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Genetic Tests for Retinal Cancer

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Anatomical Context for Retinal Cancer

Organs/tissues related to Retinal Cancer:

MalaCards : Retina, Eye, Brain, T Cells, Spleen, Thyroid, Lung

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Publications for Retinal Cancer

Articles related to Retinal Cancer:

(show top 50) (show all 185)

#	Title	Authors	PMID	Year
1	Moth-Eaten Retinal Tumor in a Teenager. ⁶²	Caudill GB...Shields CL	36441152	2022
2	Large Vasoproliferative Retinal Tumor Refractory to Cryotherapy Treated with Salvage I-125 Plaque Radiation Therapy. ⁶²	Case MJ...Cooper SL	35665307	2022
3	Gorlin Syndrome Associated With a Solitary Circumscribed Retinal Astrocytic Proliferation in a Pediatric Patient. ⁶²	Lopez-Canizares A...Berrocal AM	36107625	2022
4	Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging. ⁶²	Ashkenazy N...Correa ZM	35990798	2022
5	MULTIMODAL IMAGING OF CRB1 RETINITIS PIGMENTOSA WITH A PERIPHERAL RETINAL TUMOR. ⁶²	Corvi F...Sadda SR	32976229	2022
6	Noninvasive Imaging of a Vasoproliferative Retinal Tumor Treated with Cryopexy. ⁶²	Tanimukai T...Ishida S	36160494	2022
7	EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN A CASE OF FOCAL NODULAR GLIOSIS OF THE RETINA. ⁶²	Tagami M...Honda S	32058355	2022
8	Subtle Combined Hamartoma of the Retina and Retinal Pigment Epithelium Causing Recurrent Exodeviation. ⁶²	Abramowicz S...Postolache L	35702519	2022
9	Monte Carlo simulation of tilted contact plaque brachytherapy placement for juxtapapillary retinoblastoma. ⁶²	Nakamura S...Igaki H	35073956	2022
10	The two-hit theory hits 50. ⁶²	Chernoff J	34735271	2021
11	[Clinical features of patients with retinocytoma]. ⁶²	Yi XQ...Xue K	34256473	2021
12	Swept-Source OCTA Imaging of a Presumed Solitary Circumscribed Retinal Astrocytic Proliferation. ⁶²	Ansary MF...Souied EH	34039189	2021
13	Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. ⁶²	Schieffer KM...Boue DR	33827698	2021
14	Intravenous Chemotherapy for Retinoblastoma in the Era of Intravitreal Chemotherapy: A Systematic Review. ⁶²	Raval V...Singh A	33981697	2021
15	RETINOCYTOMA WITH VITREOUS SEEDING: NEW INSIGHTS FROM ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY AND HIGH-RESOLUTION POSTERIOR SEGMENT ULTRASONOGRAPHY. ⁶²	Garoon RB...Harbour JW	29470300	2021
16	Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma. ⁶²	Tonorezos ES...Abramson DH	32422154	2020
17	Autophagy-related gene 7 deficiency caused by miR-154-5p overexpression suppresses the cell viability and tumorigenesis of retinoblastoma by increasing cell apoptosis. ⁶²	Liu Z...Wang Y	33313196	2020
18	GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision. ⁶²	Wang K...Han Z	33898999	2020
19	Indocyanine green angiographic findings in seven eyes with vasoproliferative retinal tumor. ⁶²	Matsuura S...Ohno-Matsui K	32715159	2020
20	Retinoblastoma: Etiology, Modeling, and Treatment. ⁶²	Kaewkhaw R...Rojanaporn D	32824373	2020
21	Molecular analysis confirms retinoblastoma diagnosis in a histologically undifferentiated retinal tumor in an adult. ⁶²	Soliman SE...Krema H	32543965	2020
22	Patient-reported outcome measures for retinoblastoma: a scoping review. ⁶²	Janic A...Dimaras H	32770435	2020
23	Unilateral retinocytoma associated with a variant in the RB1 gene. ⁶²	Wu S...Sui R	31997559	2020
24	Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism. ⁶²	Song WP...Li L	32143590	2020
25	Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile. ⁶²	Puglia C...Bucolo C	32046269	2020
26	Choroidal Melanoma Simulating Adenoma of the Retinal Pigment Epithelium Arising at the Site of Congenital Hypertrophy of the Retinal Pigment Epithelium. ⁶²	Williams BK...Shields CL	32002404	2020
27	Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma. ⁶²	Liang TY...Zhao PQ	32090035	2020
28	The Relationship Between Vasoproliferative Tumor and Uveitis in a Multiple Sclerosis Patient: A Case Report and Review of the Literature ⁶²	Ozalp O...Yildirim N	31893594	2019
29	Efficacy of Retinal Lesion Screening in Von Hippel-Lindau Patients With Widefield Color Fundus Imaging Versus Widefield FA. ⁶²	Golas L...Blair MP	31755976	2019
30	Laser-induced plasmon-mediated treatment of retinoblastoma in viscous vitreous phantom. ⁶²	Darviot C...Meunier M	31297950	2019
31	Ras activation in retinal progenitor cells induces tumor formation in the eye. ⁶²	Koso H...Watanabe S	30500365	2019
32	The Use of OCT and OCT Angiography in Detecting an Atypical Case of Retinal Capillary Hemangioma. ⁶²	Pierro L...Bandello F	30893462	2019
33	Intravitreal dexamethasone implant with retinal photocoagulation for adult-onset Coats' disease. ⁶²	Kumar K...Agarwal A	29380183	2019
34	A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation. ⁶²	Li Z...Cobrinik D	30643022	2019
35	SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA. ⁶²	Lasave AF...Deromedis P	28358746	2019
36	Presumed solitary circumscribed retinal astrocytic proliferation: a lesion that can regress. ⁶²	Asensio-Sanchez VM	31118830	2019
37	ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway. ⁶²	He M...Wang S	30315856	2018
38	Eye salvage in diffuse anterior retinoblastoma using systemic chemotherapy with periocular and intravitreal topotecan. ⁶²	Rao R...Reddy VAP	29698780	2018
39	Presumed Solitary Circumscribed Retinal Astrocytic Proliferation in the Fovea With OCT Angiography: A Misnomer. ⁶²	Goldberg RA...Raja KM	29554391	2018
40	Spectrum of germline RB1 mutations and clinical manifestations in retinoblastoma patients from Thailand. ⁶²	Rojanaporn D...Hongeng S	30636860	2018
41	661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively. ⁶²	Sayyad Z...Swarup G	29203899	2017
42	Generation of two H1 hESC sublines carrying a heterozygous and homozygous knock-out of RB1. ⁶²	Steenpass L	29246572	2017
43	Retinal astrocytoma in a dog. ⁶²	Kuroki K...Ota-Kuroki J	28878413	2017
44	Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma. ⁶²	Pierro L...Bandello F	28810047	2017
45	Intracameral Chemotherapy (Melphalan) for Aqueous Seeding in Retinoblastoma: Bicameral Injection Technique and Related Toxicity in a Pilot Case Study. ⁶²	Munier FL...Beck-Popovic M	28868287	2017
46	Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. ⁶²	Xie C...Hallstrom TC	28445155	2017
47	CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. ⁶²	Portillo JC...Subauste CS	27474370	2017
48	SOLITARY CIRCUMSCRIBED "PEARL WHITE" RETINAL MASS (SO-CALLED RETINAL ASTROCYTIC PROLIFERATION) RESIDES IN DEEP RETINA OR BENEATH RETINA: FINDINGS ON MULTIMODAL IMAGING IN 4 CASES. ⁶²	Shields CL...Shields JA	26752524	2017
49	Epigenetic regulation of human retinoblastoma. ⁶²	Singh U...Kaur J	27639385	2016
50	Kif14 overexpression accelerates murine retinoblastoma development. ⁶²	O'Hare M...Corson TW	27270502	2016

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Genes for Retinal Cancer

Genes related to Retinal Cancer (0 elite genes):

(show top 50) (show all 74)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	H2AC18	H2A Clustered Histone 18	Protein Coding	11.86	DISEASES inferred ¹⁴ ¹⁴
2	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	10.29	DISEASES inferred ¹⁴ ¹⁴
3	MIR17	MicroRNA 17	RNA Gene	9.92	DISEASES inferred ¹⁴ ¹⁴
4	MIR675	MicroRNA 675	RNA Gene	9.58	DISEASES inferred ¹⁴ ¹⁴
5	MIR199A1	MicroRNA 199a-1	RNA Gene	9.46	DISEASES inferred ¹⁴ ¹⁴
6	CDK4	Cyclin Dependent Kinase 4	Protein Coding	9.34	DISEASES inferred ¹⁴
7	KDM4C	Lysine Demethylase 4C	Protein Coding	9.29	DISEASES inferred ¹⁴ ¹⁴
8	MIR21	MicroRNA 21	RNA Gene	9.27	DISEASES inferred ¹⁴ ¹⁴
9	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	9.19	DISEASES inferred ¹⁴
10	RB1	RB Transcriptional Corepressor 1	Protein Coding	9.14	DISEASES inferred ¹⁴
11	TP53	Tumor Protein P53	Protein Coding	9.14	DISEASES inferred ¹⁴
12	MIR125A	MicroRNA 125a	RNA Gene	9.13	DISEASES inferred ¹⁴ ¹⁴
13	MIR361	MicroRNA 361	RNA Gene	9.11	DISEASES inferred ¹⁴ ¹⁴
14	MIR34A	MicroRNA 34a	RNA Gene	8.96	DISEASES inferred ¹⁴ ¹⁴
15	CDK2	Cyclin Dependent Kinase 2	Protein Coding	8.95	DISEASES inferred ¹⁴
16	MIR9-1	MicroRNA 9-1	RNA Gene	8.95	DISEASES inferred ¹⁴ ¹⁴
17	CCND1	Cyclin D1	Protein Coding	8.85	DISEASES inferred ¹⁴
18	MIR20A	MicroRNA 20a	RNA Gene	8.81	DISEASES inferred ¹⁴ ¹⁴
19	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	8.81	DISEASES inferred ¹⁴
20	E2F1	E2F Transcription Factor 1	Protein Coding	8.77	DISEASES inferred ¹⁴
21	E2F4	E2F Transcription Factor 4	Protein Coding	8.76	DISEASES inferred ¹⁴
22	CDK6	Cyclin Dependent Kinase 6	Protein Coding	8.73	DISEASES inferred ¹⁴
23	MIR142	MicroRNA 142	RNA Gene	8.72	DISEASES inferred ¹⁴ ¹⁴
24	MIR214	MicroRNA 214	RNA Gene	8.69	DISEASES inferred ¹⁴ ¹⁴
25	E2F5	E2F Transcription Factor 5	Protein Coding	8.63	DISEASES inferred ¹⁴
26	TCHP	Trichoplein Keratin Filament Binding	Protein Coding	8.61	DISEASES inferred ¹⁴
27	E2F2	E2F Transcription Factor 2	Protein Coding	8.59	DISEASES inferred ¹⁴
28	E2F6	E2F Transcription Factor 6	Protein Coding	8.58	DISEASES inferred ¹⁴
29	E2F8	E2F Transcription Factor 8	Protein Coding	8.58	DISEASES inferred ¹⁴
30	E2F3	E2F Transcription Factor 3	Protein Coding	8.55	DISEASES inferred ¹⁴
31	E2F7	E2F Transcription Factor 7	Protein Coding	8.54	DISEASES inferred ¹⁴
32	MIR34C	MicroRNA 34c	RNA Gene	8.54	DISEASES inferred ¹⁴ ¹⁴
33	MIR204	MicroRNA 204	RNA Gene	8.53	DISEASES inferred ¹⁴ ¹⁴
34	MIR155	MicroRNA 155	RNA Gene	8.5	DISEASES inferred ¹⁴ ¹⁴
35	MIR365A	MicroRNA 365a	RNA Gene	8.47	DISEASES inferred ¹⁴ ¹⁴
36	MIR140	MicroRNA 140	RNA Gene	8.45	DISEASES inferred ¹⁴ ¹⁴
37	MIR15A	MicroRNA 15a	RNA Gene	8.43	DISEASES inferred ¹⁴ ¹⁴
38	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	8.43	DISEASES inferred ¹⁴
39	CCNA2	Cyclin A2	Protein Coding	8.41	DISEASES inferred ¹⁴
40	MIR106B	MicroRNA 106b	RNA Gene	8.4	DISEASES inferred ¹⁴ ¹⁴
41	CRYAA	Crystallin Alpha A	Protein Coding	8.38	DISEASES inferred ¹⁴ ¹⁴
42	MIR221	MicroRNA 221	RNA Gene	8.33	DISEASES inferred ¹⁴ ¹⁴
43	MIR132	MicroRNA 132	RNA Gene	8.31	DISEASES inferred ¹⁴ ¹⁴
44	MIR193A	MicroRNA 193a	RNA Gene	8.26	DISEASES inferred ¹⁴ ¹⁴
45	MIR196A1	MicroRNA 196a-1	RNA Gene	8.22	DISEASES inferred ¹⁴ ¹⁴
46	MIR224	MicroRNA 224	RNA Gene	8.2	DISEASES inferred ¹⁴ ¹⁴
47	MIR30A	MicroRNA 30a	RNA Gene	8.2	DISEASES inferred ¹⁴ ¹⁴
48	MIR373	MicroRNA 373	RNA Gene	8.19	DISEASES inferred ¹⁴ ¹⁴
49	MIR491	MicroRNA 491	RNA Gene	8.17	DISEASES inferred ¹⁴ ¹⁴
50	MIR518C	MicroRNA 518c	RNA Gene	8.1	DISEASES inferred ¹⁴ ¹⁴

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Variations for Retinal Cancer

Cosmic variations for Retinal Cancer:

⁸ (show all 49)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM86647435	RB1	eye,retina,retinoblastoma,NS	c.2106+2T>G	p.?	13:48459835-48459835	9
2	COSM86634466	RB1	eye,retina,retinoblastoma,NS	c.380+1G>T	p.?	13:48342715-48342715	9
3	COSM86624550	RB1	eye,retina,retinoblastoma,NS	c.1333C>T	p.R445*	13:48379594-48379594	9
4	COSM86651352	RB1	eye,retina,retinoblastoma,NS	c.1421G>A	p.S474N	13:48380084-48380084	9
5	COSM86624126	RB1	eye,retina,retinoblastoma,NS	c.751C>T	p.R251*	13:48362847-48362847	9
6	COSM86624950	RB1	eye,retina,retinoblastoma,NS	c.1183C>T	p.Q395*	13:48373460-48373460	9
7	COSM86626226	RB1	eye,retina,retinoblastoma,NS	c.958C>T	p.R320*	13:48367512-48367512	9
8	COSM86647609	RB1	eye,retina,retinoblastoma,NS	c.1960+2T>C	p.?	13:48456351-48456351	9
9	COSM86625405	RB1	eye,retina,retinoblastoma,NS	c.1666C>T	p.R556*	13:48381414-48381414	9
10	COSM86626205	RB1	eye,retina,retinoblastoma,NS	c.1363C>T	p.R455*	13:48379624-48379624	9
11	COSM86628490	RB1	eye,retina,retinoblastoma,NS	c.763C>T	p.R255*	13:48362859-48362859	9
12	COSM86642443	RB1	eye,retina,retinoblastoma,NS	c.2527G>T	p.E843*	13:48476707-48476707	9
13	COSM86636835	RB1	eye,retina,retinoblastoma,NS	c.2326-2A>C	p.?	13:48465203-48465203	9
14	COSM86633737	RB1	eye,retina,retinoblastoma,NS	c.967G>T	p.E323*	13:48367521-48367521	9
15	COSM86624252	RB1	eye,retina,retinoblastoma,NS	c.1215+1G>A	p.?	13:48373493-48373493	9
16	COSM86631349	RB1	eye,retina,retinoblastoma,NS	c.2158A>T	p.K720*	13:48463782-48463782	9
17	COSM86627680	RB1	eye,retina,retinoblastoma,NS	c.1166T>A	p.L389*	13:48373443-48373443	9
18	COSM86638492	RB1	eye,retina,retinoblastoma,NS	c.1216-2A>G	p.?	13:48376916-48376916	9
19	COSM86629052	RB1	eye,retina,retinoblastoma,NS	c.1961-1G>A	p.?	13:48459687-48459687	9
20	COSM86640644	RB1	eye,retina,retinoblastoma,NS	c.1467C>A	p.C489*	13:48380210-48380210	9
21	COSM86635450	RB1	eye,retina,retinoblastoma,NS	c.2053C>T	p.Q685*	13:48459780-48459780	9
22	COSM86637950	RB1	eye,retina,retinoblastoma,NS	c.265-2A>C	p.?	13:48342597-48342597	9
23	COSM86629160	RB1	eye,retina,retinoblastoma,NS	c.409G>T	p.E137*	13:48345108-48345108	9
24	COSM86624395	RB1	eye,retina,retinoblastoma,NS	c.2520+4A>G	p.?	13:48473394-48473394	9
25	COSM86640590	RB1	eye,retina,retinoblastoma,NS	c.1891C>T	p.Q631*	13:48456280-48456280	9
26	COSM86656361	RB1	eye,retina,retinoblastoma,NS	c.982A>C	p.N328H	13:48367536-48367536	9
27	COSM86630951	RB1	eye,retina,retinoblastoma,NS	c.1654C>T	p.R552*	13:48381402-48381402	9
28	COSM86631559	RB1	eye,retina,retinoblastoma,NS	c.1049+1G>T	p.?	13:48367604-48367604	9
29	COSM86632900	RB1	eye,retina,retinoblastoma,NS	c.2063T>C	p.L688P	13:48459790-48459790	9
30	COSM150688162	RB1	eye,retina,retinoblastoma,NS	c.160G>T	p.E54*	13:48307302-48307302	9
31	COSM86649095	RB1	eye,retina,retinoblastoma,NS	c.2106+1G>T	p.?	13:48459834-48459834	9
32	COSM86626876	RB1	eye,retina,retinoblastoma,NS	c.2206C>T	p.Q736*	13:48463830-48463830	9
33	COSM86637333	RB1	eye,retina,retinoblastoma,NS	c.341C>A	p.S114*	13:48342675-48342675	9
34	COSM86632739	RB1	eye,retina,retinoblastoma,NS	c.1960+1G>A	p.?	13:48456350-48456350	9
35	COSM86630352	RB1	eye,retina,retinoblastoma,NS	c.862-5T>G	p.?	13:48364889-48364889	9
36	COSM86632080	RB1	eye,retina,retinoblastoma,NS	c.160G>T	p.E54*	13:48307302-48307302	9
37	COSM86654450	RB1	eye,retina,retinoblastoma,NS	c.2152G>A	p.D718N	13:48463776-48463776	9
38	COSM86640621	RB1	eye,retina,retinoblastoma,NS	c.1389+1G>C	p.?	13:48379651-48379651	9
39	COSM86648958	RB1	eye,retina,retinoblastoma,NS	c.1494T>A	p.Y498*	13:48380237-48380237	9
40	COSM87132285	PIK3CA	eye,retina,retinoblastoma,NS	c.1634A>G	p.E545G	3:179218304-179218304	9
41	COSM148932691	PIK3CA	eye,retina,retinoblastoma,NS	c.1634A>G	p.E545G	3:179218304-179218304	9
42	COSM91859716	KRAS	eye,retina,retinoblastoma,NS	c.35G>A	p.G12D	12:25245350-25245350	9
43	COSM87804005	KRAS	eye,retina,retinoblastoma,NS	c.35G>A	p.G12D	12:25245350-25245350	9
44	COSM87804055	KRAS	eye,retina,retinoblastoma,NS	c.35G>T	p.G12V	12:25245350-25245350	9
45	COSM134990158	KRAS	eye,retina,retinoblastoma,NS	c.35G>T	p.G12V	12:25245350-25245350	9
46	COSM134614922	KRAS	eye,retina,retinoblastoma,NS	c.35G>A	p.G12D	12:25245350-25245350	9
47	COSM134990112	KRAS	eye,retina,retinoblastoma,NS	c.35G>A	p.G12D	12:25245350-25245350	9
48	COSM134614978	KRAS	eye,retina,retinoblastoma,NS	c.35G>T	p.G12V	12:25245350-25245350	9
49	COSM91859752	KRAS	eye,retina,retinoblastoma,NS	c.35G>T	p.G12V	12:25245350-25245350	9

Sources

Expression for Retinal Cancer

Search GEO for disease gene expression data for Retinal Cancer.

Sources

Pathways for Retinal Cancer

Pathways related to Retinal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 68)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.84	APC CCND1 CDK2 CDK4 CDKN2A E2F1
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.82	TP53 RB1 H2AC18 E2F1 CDKN2A CDK4
3	Signal Transduction ⁶⁶	13.8	TP53 RBL1 KDM4C H2AC18 E2F1 CDK4
4	RNA Polymerase I Promoter Opening ⁶⁶ Show member pathways Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ⁶⁶ Activation of anterior HOX genes in hindbrain development during early embryogenesis ⁶⁶ Activation of HOX genes during differentiation ⁶⁶ Amyloid fiber formation ⁶⁶ Assembly of the ORC complex at the origin of replication ⁶⁶ Binding of TCF/LEF:CTNNB1 to target gene promoters ⁶⁶ B-WICH complex positively regulates rRNA expression ⁶⁶ Condensation of Prophase Chromosomes ⁶⁶ Defective pyroptosis ⁶⁶ Diseases of programmed cell death ⁶⁶ DNA methylation ⁶⁶ Epigenetic regulation of gene expression ⁶⁶ ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression ⁶⁶ Formation of the beta-catenin:TCF transactivating complex ⁶⁶ HDACs deacetylate histones ⁶⁶ HDMs demethylate histones ⁶⁶ Negative epigenetic regulation of rRNA expression ⁶⁶ NoRC negatively regulates rRNA expression ⁶⁶ Positive epigenetic regulation of rRNA expression ⁶⁶ PRC2 methylates histones and DNA ⁶⁶ RHO GTPases activate PKNs ⁶⁶ RMTs methylate histone arginines ⁶⁶ RNA Polymerase I Promoter Clearance ⁶⁶ RNA Polymerase I Promoter Escape ⁶⁶ RNA Polymerase I Transcription ⁶⁶ RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ⁶⁶ SIRT1 negatively regulates rRNA expression ⁶⁶ TET1,2,3 and TDG demethylate DNA ⁶⁶ Transcriptional regulation of granulopoiesis ⁶⁶	13.79	CCND1 CDK2 CDK4 CDKN2A E2F1 H2AC18
5	Cell Cycle, Mitotic ⁶⁶ Show member pathways Cell Cycle ⁶⁶ M Phase ⁶⁶	13.55	TP53 RBL1 RB1 H2AC18 E2F1 CDKN2A
6	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.49	APC CCND1 CDK2 CDK4 CDKN2A E2F1
7	Cellular Senescence ⁶⁶ Show member pathways Oxidative Stress Induced Senescence ⁶⁶ Senescence-Associated Secretory Phenotype (SASP) ⁶⁶	12.83	TP53 RB1 H2AC18 E2F1 CDKN2A CDK4
8	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.81	APC CCND1 CDK4 CDKN2A E2F1 RB1
9	Malignant pleural mesothelioma ⁷⁴	12.79	TP53 E2F1 CDKN2A CDK4 CDK2 CCND1
10	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ SREBP Proteolysis ⁶⁴	12.7	CCND1 CDK2 CDK4 E2F1 RB1 RBL1
11	DNA Damage ³	12.61	TP53 RB1 E2F1 CDKN2A CDK4 CDK2
12	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects ⁶⁶ Show member pathways Aberrant regulation of mitotic cell cycle due to RB1 defects ⁶⁶ Aberrant regulation of mitotic exit in cancer due to RB1 defects ⁶⁶ Cell cycle Cell cycle (generic schema) ²² Cell cycle Regulation of G1/S transition (part 2) ²² Cyclin D associated events in G1 ⁶⁶ Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) ⁶⁶ Defective translocation of RB1 mutants to the nucleus ⁶⁶ Diseases of mitotic cell cycle ⁶⁶ Drug-mediated inhibition of CDK4/CDK6 activity ⁶⁶ G1 Phase ⁶⁶ G2 Phase ⁶⁶ Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes ⁶⁶ PTK6 Regulates Cell Cycle ⁶⁶	12.58	RBL1 RB1 E2F1 CDKN2A CDK4 CDK2
13	Mitotic G1 phase and G1/S transition ⁶⁶ Show member pathways G1/S Transition ⁶⁶	12.57	CCND1 CDK2 CDK4 CDKN2A E2F1 RB1
14	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.56	APC CCND1 CDK4 E2F1 RB1 TP53
15	Cell cycle Regulation of G1/S transition (part 1) ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Role of SCF complex in cell cycle regulation ²² Immune response MIF-JAB1 signaling ²² Mitotic Roles of Polo Like Kinases ⁶⁴	12.49	RB1 E2F1 CDKN2A CDK4 CDK2 CCND1
16	WNT Signaling ⁶⁴	12.4	APC CCND1 CDK2 CDK4 E2F1 RB1
17	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.32	TP53 RB1 E2F1 CDK4 CDK2 CCND1
18	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.31	TP53 RB1 E2F1 CDK4 CDK2 CCND1
19	Integrated breast cancer pathway ⁷⁴	12.24	TP53 RB1 E2F1 CDK4 CDK2 CCND1
20	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.18	TP53 CDKN2A CDK4 CCND1
21	Direct p53 effectors ⁶¹	12.1	TP53 RB1 E2F1 APC
22	Spinal cord injury ⁷⁴	12.07	CCND1 CDK2 CDK4 E2F1 RB1 TP53
23	Cyclins and Cell Cycle Regulation ⁶⁴ Show member pathways Cell Cycle Control by BTG Proteins ⁶⁴ G1-S Phase Transition ⁶⁴	12.02	CCND1 CDK2 CDK4 CDKN2A E2F1 RB1
24	Senescence and autophagy in cancer ⁷⁴	12.01	TP53 RB1 E2F1 CDKN2A
25	TP53 Regulates Transcription of Cell Cycle Genes ⁶⁶ Show member pathways TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain ⁶⁶ TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest ⁶⁶ TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest ⁶⁶ Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer ⁷⁴	11.99	TP53 RBL1 E2F1 CDK2
26	Overlap between signal transduction pathways contributing to LMNA laminopathies ⁷⁴ Show member pathways Influence of laminopathies on Wnt signaling ⁷⁴	11.99	RB1 E2F1 CDK4 CCND1 APC
27	Small cell lung cancer ⁷⁴	11.97	TP53 RB1 E2F1 CDK4 CDK2 CCND1
28	miRNA regulation of DNA damage response ⁷⁴ Show member pathways DNA damage response ⁷⁴	11.95	CCND1 CDK2 CDK4 E2F1 MIR20A RB1
29	DNA damage response (only ATM dependent) ⁷⁴	11.92	TP53 CCND1 APC
30	DNA IR-double strand breaks and cellular response via ATM ⁷⁴ Show member pathways ATM pathway ⁶¹ DNA damage_DNA-damage-induced responses ²²	11.91	TP53 E2F1 CDKN2A
31	G0 and Early G1 ⁶⁶ Show member pathways G1/S-Specific Transcription ⁶⁶ Transcription of E2F targets under negative control by DREAM complex ⁶⁶ Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 ⁶⁶	11.87	RBL1 E2F1 CDK2
32	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.87	MIR17 MIR199A1 MIR20A MIR9-1
33	Retinoblastoma gene in cancer ⁷⁴	11.87	TP53 RB1 E2F1 CDK4 CDK2 CCND1
34	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.83	TP53 RB1 E2F1
35	DNA IR-damage and cellular response via ATR ⁷⁴	11.82	TP53 E2F1 CDK2
36	E2F transcription factor network ⁶¹	11.82	CDK2 CDKN2A E2F1 RB1 RBL1
37	Cell cycle ⁷⁴ Show member pathways G1 to S cell cycle control ⁷⁴	11.82	TP53 RBL1 RB1 E2F1 CDKN2A CDK4
38	Transcription_P53 signaling pathway ²²	11.8	TP53 RB1 E2F1 CDKN2A CDK2
39	Regulation of TP53 Expression and Degradation ⁶⁶ Show member pathways Regulation of TP53 Degradation ⁶⁶ Regulation of TP53 Expression ⁶⁶	11.78	TP53 CDKN2A CDK2
40	Head and neck squamous cell carcinoma ⁷⁴	11.77	TP53 RB1 E2F1 CDKN2A CDK4 CCND1
41	Regulation of nuclear beta catenin signaling and target gene transcription ⁶¹	11.76	CDKN2A CCND1 APC
42	DYRK1A ⁷⁴	11.76	TP53 RBL1 CDK4 CCND1
43	AP-1 transcription factor network ⁶¹	11.74	TP53 CDKN2A CCND1
44	Regulation of retinoblastoma protein ⁶¹	11.71	RB1 E2F1 CDKN2A CDK4 CDK2
45	miRNAs involvement in the immune response in sepsis ⁷⁴	11.68	MIR9-1 MIR21 MIR199A1
46	Coregulation of Androgen receptor activity ⁶¹	11.68	KDM4C CDKN2A CCND1
47	miRNAs involved in DNA damage response ⁷⁴	11.67	TP53 MIR21 MIR20A MIR17 E2F1 CCND1
48	Thyroid stimulating hormone (TSH) signaling pathway ⁷⁴	11.65	RB1 CDK4 CDK2
49	Copper homeostasis ⁷⁴ Show member pathways Copper metabolism ⁷⁴ Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) ⁶⁶	11.65	TP53 CCND1 APC
50	ATF-2 transcription factor network ⁶¹	11.64	RB1 CDK4 CCND1

Sources

GO Terms for Retinal Cancer

Cellular components related to Retinal Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription regulator complex	GO:0005667	9.9	CDK2 CDK4 E2F1 RB1 RBL1 TP53
2	cyclin-dependent protein kinase holoenzyme complex	GO:0000307	9.85	CDK4 CDK2 CCND1
3	Rb-E2F complex	GO:0035189	9.62	RB1 E2F1
4	intracellular organelle	GO:0043229	9.58	RBL1 RB1 KDM4C
5	cyclin D1-CDK4 complex	GO:0097128	9.56	CDK4 CCND1
6	RISC complex	GO:0016442	9.53	MIR9-1 MIR675 MIR361 MIR21 MIR20A MIR199A1
7	extracellular vesicle	GO:1903561	9.35	MIR34A MIR21 MIR20A MIR17 MIR125A

Biological processes related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 33)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.28	TP53 RB1 MIR9-1 MIR21 CDKN2A APC
2	positive regulation of apoptotic process	GO:0043065	10.26	TP53 MIR21 E2F1 CDKN2A APC
3	positive regulation of gene expression	GO:0010628	10.19	TP53 MIR34A MIR21 MIR17 MIR125A E2F1
4	miRNA-mediated gene silencing	GO:0035195	10.19	MIR125A MIR17 MIR199A1 MIR20A MIR21 MIR34A
5	Ras protein signal transduction	GO:0007265	10.18	CDK2 CDKN2A RB1 TP53
6	negative regulation of G1/S transition of mitotic cell cycle	GO:2000134	10.13	RBL1 RB1 APC
7	cell cycle	GO:0007049	10.13	TP53 RBL1 RB1 E2F1 CDKN2A CDK4
8	cellular response to hypoxia	GO:0071456	10.11	E2F1 MIR17 MIR34A TP53
9	G1/S transition of mitotic cell cycle	GO:0000082	9.97	RB1 E2F1 CDK4 CDK2 CCND1
10	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.95	E2F1 MIR125A MIR199A1 MIR9-1 RB1
11	mitotic G1 DNA damage checkpoint signaling	GO:0031571	9.93	TP53 CDK2 CCND1
12	negative regulation of gene expression	GO:0010629	9.93	MIR125A MIR17 MIR199A1 MIR20A MIR21 MIR34A
13	regulation of lipid kinase activity	GO:0043550	9.92	RBL1 RB1
14	negative regulation of angiogenesis	GO:0016525	9.92	MIR125A MIR21 MIR34A MIR361
15	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	GO:0071930	9.91	RB1 E2F1
16	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.82	MIR21 MIR20A MIR17
17	positive regulation of cardiac muscle cell apoptotic process	GO:0010666	9.81	MIR17 MIR34A TP53
18	negative regulation of protein serine/threonine kinase activity	GO:0071901	9.8	RB1 MIR34A MIR20A
19	regulation of cell cycle	GO:0051726	9.8	TP53 RBL1 RB1 MIR34A E2F1 CDKN2A
20	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.79	MIR361 MIR20A MIR199A1
21	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.78	MIR9-1 MIR21 MIR20A MIR17
22	negative regulation of cardiac muscle cell apoptotic process	GO:0010667	9.77	MIR21 MIR20A MIR199A1
23	negative regulation of mitotic cell cycle	GO:0045930	9.77	TP53 RB1 MIR21
24	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.76	MIR675 MIR21 MIR17
25	re-entry into mitotic cell cycle	GO:0000320	9.74	MIR199A1 CCND1
26	negative regulation of sprouting angiogenesis	GO:1903671	9.72	MIR34A MIR20A MIR17
27	positive regulation of connective tissue replacement	GO:1905205	9.66	MIR34A MIR199A1
28	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.64	MIR21 MIR17
29	positive regulation of metalloendopeptidase activity	GO:1904685	9.63	MIR21 MIR17
30	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.56	MIR20A MIR17
31	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.54	MIR20A MIR199A1 MIR17
32	negative regulation of superoxide dismutase activity	GO:1901670	9.52	MIR675 MIR21
33	negative regulation of vascular endothelial growth factor production	GO:1904046	9.1	MIR361 MIR34A MIR20A MIR199A1 MIR17 MIR125A

Molecular functions related to Retinal Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA base-pairing translational repressor activity	GO:1903231	9.61	MIR9-1 MIR675 MIR361 MIR34A MIR21 MIR20A
2	disordered domain specific binding	GO:0097718	9.55	TP53 RB1 CDKN2A
3	mRNA 3'-UTR binding	GO:0003730	9.36	TP53 MIR9-1 MIR675 MIR361 MIR34A MIR21

Sources

Sources for Retinal Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: RTN015 MIFTS: 52	Retinal Cancer Categories: Cancer diseases, Eye diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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