MCID: RTN015
MIFTS: 52

Retinal Cancer

Categories: Cancer diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Retinal Cancer

MalaCards integrated aliases for Retinal Cancer:

Name: Retinal Cancer 11 14 16 75 33
Malignant Neoplasm of Retina 11 71 33
Retinal Neoplasms 43 71
Primary Malignant Neoplasm of Retina 33
Malignant Retinal Neoplasm 11
Malignant Tumour of Retina 33
Malignant Tumor of Retina 11
Malignant Retinal Tumour 33
Cancer of the Retina 33
Neoplasm of Retina 11
Retinal Neoplasm 16
Retinal Tumor 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4645
ICD9CM 34 190.5
MeSH 43 D019572
NCIt 49 C3216 C4800
SNOMED-CT 68 127002001 93987004
ICD10 31 C69.2
UMLS 71 C0024622 C0524801

Summaries for Retinal Cancer

MalaCards based summary: Retinal Cancer, also known as malignant neoplasm of retina, is related to retinoblastoma and retinal disease. An important gene associated with Retinal Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and brain, and related phenotypes are neoplasm and endocrine/exocrine gland

Wikipedia: 75 Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,... more...

Related Diseases for Retinal Cancer

Diseases related to Retinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 retinoblastoma 32.2 TP53 RBL1 RB1 MIR34A E2F1 CDKN2A
2 retinal disease 31.9 TP53 RBL1 RB1 MIR9-1 MIR675 MIR361
3 retinitis pigmentosa 30.4 TP53 MIR9-1 MIR21 MIR17 MIR125A KDM4C
4 retinal vascular disease 30.3 MIR21 MIR20A MIR199A1 MIR17 H2AC18
5 osteogenic sarcoma 30.2 TP53 RBL1 RB1 MIR199A1 E2F1 CDKN2A
6 melanoma, uveal 30.2 TP53 MIR9-1 MIR199A1 MIR17 MIR125A KDM4C
7 vasoproliferative tumor of the retina 10.9
8 cystadenocarcinoma 10.6 TP53 MIR21 MIR199A1
9 urinary bladder inverted papilloma 10.5 RB1 CDKN2A
10 extrinsic cardiomyopathy 10.5 MIR21 MIR199A1 MIR17 H2AC18
11 verrucous carcinoma 10.5 TP53 MIR125A CDKN2A
12 adenoma 10.5 TP53 CDKN2A CCND1 APC
13 suppressor of tumorigenicity 3 10.5 TP53 RB1 CDKN2A
14 anal squamous cell carcinoma 10.5 TP53 H2AC18 CDKN2A
15 cardiovascular organ benign neoplasm 10.5 TP53 MIR199A1 MIR17 H2AC18 APC
16 esophagus verrucous carcinoma 10.5 TP53 CDKN2A CCND1
17 testicular disease 10.5 TP53 MIR199A1 KDM4C H2AC18
18 intrahepatic cholangiocarcinoma 10.5 TP53 MIR199A1 MIR17 KDM4C H2AC18
19 diffuse astrocytoma 10.5 TP53 KDM4C H2AC18 CDKN2A
20 bilateral retinoblastoma 10.5 TP53 RBL1 RB1 E2F1
21 anus cancer 10.5 TP53 RB1 H2AC18 CDKN2A
22 rhabdoid cancer 10.5 TP53 MIR9-1 KDM4C H2AC18
23 anogenital venereal wart 10.5 TP53 RB1 H2AC18 CDKN2A
24 glioma 10.5 TP53 MIR34A MIR21 MIR20A MIR17
25 hereditary melanoma 10.5 CDKN2A CDK4
26 bone remodeling disease 10.5 MIR675 MIR199A1 MIR17 H2AC18
27 intrinsic cardiomyopathy 10.5 MIR21 MIR199A1 MIR17 H2AC18
28 mediastinum liposarcoma 10.5 CDKN2A CDK4
29 ovarian cystadenocarcinoma 10.5 TP53 MIR17 H2AC18 CDKN2A
30 estrogen-receptor negative breast cancer 10.5 TP53 H2AC18 CCND1
31 myxofibrosarcoma 10.5 TP53 H2AC18 CDKN2A CDK4
32 peritoneum cancer 10.5 TP53 H2AC18 CDKN2A
33 bone resorption disease 10.5 MIR675 MIR199A1 MIR17 MIR125A H2AC18
34 childhood medulloblastoma 10.5 TP53 KDM4C H2AC18
35 ovarian clear cell carcinoma 10.5 TP53 MIR9-1 MIR21 MIR199A1 H2AC18
36 uterus carcinoma in situ 10.5 TP53 RB1 CDKN2A
37 cervix uteri carcinoma in situ 10.5 TP53 RB1 CDKN2A
38 connective tissue benign neoplasm 10.5 TP53 H2AC18 CDK4
39 germ cell and embryonal cancer 10.5 TP53 MIR9-1 KDM4C H2AC18
40 ovary adenocarcinoma 10.5 TP53 MIR17 H2AC18 CDKN2A
41 mature t-cell and nk-cell lymphoma 10.5 TP53 MIR21 MIR199A1 MIR17 KDM4C H2AC18
42 primary cutaneous t-cell non-hodgkin lymphoma 10.5 MIR34A MIR21 MIR17 KDM4C H2AC18
43 colorectal adenocarcinoma 10.5 TP53 MIR17 H2AC18 CCND1
44 cholangiocarcinoma 10.5 TP53 MIR21 CDKN2A CCND1
45 aortic valve disease 2 10.5 MIR34A MIR21 MIR199A1 MIR17 H2AC18
46 lung adenoma 10.5 TP53 H2AC18 CDKN2A CCND1
47 autoimmune disease of skin and connective tissue 10.5 MIR21 MIR20A MIR17 H2AC18
48 nodular malignant melanoma 10.5 TP53 CDKN2A CDK4 CCND1
49 acute erythroid leukemia 10.5 TP53 KDM4C H2AC18
50 supratentorial cancer 10.5 TP53 H2AC18 CDKN2A

Graphical network of the top 20 diseases related to Retinal Cancer:



Diseases related to Retinal Cancer

Symptoms & Phenotypes for Retinal Cancer

MGI Mouse Phenotypes related to Retinal Cancer:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.24 APC CCND1 CDK2 CDK4 CDKN2A E2F1
2 endocrine/exocrine gland MP:0005379 10.17 APC CCND1 CDK2 CDK4 CDKN2A E2F1
3 immune system MP:0005387 10.1 APC CCND1 CDK2 CDK4 CDKN2A E2F1
4 no phenotypic analysis MP:0003012 10.08 CDKN2A KDM4C MIR199A1 MIR34A MIR9-1 RB1
5 muscle MP:0005369 10.06 APC CDK2 CDK4 CDKN2A E2F1 RB1
6 digestive/alimentary MP:0005381 10.01 APC CCND1 CDK4 CDKN2A E2F1 RB1
7 pigmentation MP:0001186 9.99 APC CDK4 CDKN2A E2F1 RB1 TP53
8 reproductive system MP:0005389 9.96 APC CCND1 CDK2 CDK4 CDKN2A E2F1
9 craniofacial MP:0005382 9.91 APC CCND1 CDK4 E2F1 RB1 RBL1
10 vision/eye MP:0005391 9.85 APC CCND1 CDK2 CDK4 CDKN2A E2F1
11 hematopoietic system MP:0005397 9.73 APC CCND1 CDK2 CDK4 CDKN2A E2F1
12 integument MP:0010771 9.36 APC CCND1 CDK2 CDK4 CDKN2A E2F1

Drugs & Therapeutics for Retinal Cancer

Drugs for Retinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60699 60700
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Coenzyme M Approved, Investigational Phase 3 3375-50-6 598 23662354
7
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
8
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
9
Etoposide phosphate Phase 3 16760419
10 Antirheumatic Agents Phase 3
11 Anti-Bacterial Agents Phase 3
12 Alkylating Agents Phase 3
13 Antineoplastic Agents, Alkylating Phase 3
14 Antimitotic Agents Phase 3
15 topoisomerase I inhibitors Phase 3
16 Tubulin Modulators Phase 3
17 Anesthetics Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Liposomal doxorubicin Phase 3
20 Immunosuppressive Agents Phase 3
21 Immunologic Factors Phase 3
22
Melphalan Approved Phase 2 148-82-3 4053 460612

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma Completed NCT00179920 Phase 2 Carboplatin;VP-16
3 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)

Search NIH Clinical Center for Retinal Cancer

Cochrane evidence based reviews: retinal neoplasms

Genetic Tests for Retinal Cancer

Anatomical Context for Retinal Cancer

Organs/tissues related to Retinal Cancer:

MalaCards : Retina, Eye, Brain, T Cells, Spleen, Thyroid, Lung

Publications for Retinal Cancer

Articles related to Retinal Cancer:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Moth-Eaten Retinal Tumor in a Teenager. 62
36441152 2022
2
Large Vasoproliferative Retinal Tumor Refractory to Cryotherapy Treated with Salvage I-125 Plaque Radiation Therapy. 62
35665307 2022
3
Gorlin Syndrome Associated With a Solitary Circumscribed Retinal Astrocytic Proliferation in a Pediatric Patient. 62
36107625 2022
4
Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging. 62
35990798 2022
5
MULTIMODAL IMAGING OF CRB1 RETINITIS PIGMENTOSA WITH A PERIPHERAL RETINAL TUMOR. 62
32976229 2022
6
Noninvasive Imaging of a Vasoproliferative Retinal Tumor Treated with Cryopexy. 62
36160494 2022
7
EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN A CASE OF FOCAL NODULAR GLIOSIS OF THE RETINA. 62
32058355 2022
8
Subtle Combined Hamartoma of the Retina and Retinal Pigment Epithelium Causing Recurrent Exodeviation. 62
35702519 2022
9
Monte Carlo simulation of tilted contact plaque brachytherapy placement for juxtapapillary retinoblastoma. 62
35073956 2022
10
The two-hit theory hits 50. 62
34735271 2021
11
[Clinical features of patients with retinocytoma]. 62
34256473 2021
12
Swept-Source OCTA Imaging of a Presumed Solitary Circumscribed Retinal Astrocytic Proliferation. 62
34039189 2021
13
Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. 62
33827698 2021
14
Intravenous Chemotherapy for Retinoblastoma in the Era of Intravitreal Chemotherapy: A Systematic Review. 62
33981697 2021
15
RETINOCYTOMA WITH VITREOUS SEEDING: NEW INSIGHTS FROM ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY AND HIGH-RESOLUTION POSTERIOR SEGMENT ULTRASONOGRAPHY. 62
29470300 2021
16
Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma. 62
32422154 2020
17
Autophagy-related gene 7 deficiency caused by miR-154-5p overexpression suppresses the cell viability and tumorigenesis of retinoblastoma by increasing cell apoptosis. 62
33313196 2020
18
GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision. 62
33898999 2020
19
Indocyanine green angiographic findings in seven eyes with vasoproliferative retinal tumor. 62
32715159 2020
20
Retinoblastoma: Etiology, Modeling, and Treatment. 62
32824373 2020
21
Molecular analysis confirms retinoblastoma diagnosis in a histologically undifferentiated retinal tumor in an adult. 62
32543965 2020
22
Patient-reported outcome measures for retinoblastoma: a scoping review. 62
32770435 2020
23
Unilateral retinocytoma associated with a variant in the RB1 gene. 62
31997559 2020
24
Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism. 62
32143590 2020
25
Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile. 62
32046269 2020
26
Choroidal Melanoma Simulating Adenoma of the Retinal Pigment Epithelium Arising at the Site of Congenital Hypertrophy of the Retinal Pigment Epithelium. 62
32002404 2020
27
Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma. 62
32090035 2020
28
The Relationship Between Vasoproliferative Tumor and Uveitis in a Multiple Sclerosis Patient: A Case Report and Review of the Literature 62
31893594 2019
29
Efficacy of Retinal Lesion Screening in Von Hippel-Lindau Patients With Widefield Color Fundus Imaging Versus Widefield FA. 62
31755976 2019
30
Laser-induced plasmon-mediated treatment of retinoblastoma in viscous vitreous phantom. 62
31297950 2019
31
Ras activation in retinal progenitor cells induces tumor formation in the eye. 62
30500365 2019
32
The Use of OCT and OCT Angiography in Detecting an Atypical Case of Retinal Capillary Hemangioma. 62
30893462 2019
33
Intravitreal dexamethasone implant with retinal photocoagulation for adult-onset Coats' disease. 62
29380183 2019
34
A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation. 62
30643022 2019
35
SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA. 62
28358746 2019
36
Presumed solitary circumscribed retinal astrocytic proliferation: a lesion that can regress. 62
31118830 2019
37
ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway. 62
30315856 2018
38
Eye salvage in diffuse anterior retinoblastoma using systemic chemotherapy with periocular and intravitreal topotecan. 62
29698780 2018
39
Presumed Solitary Circumscribed Retinal Astrocytic Proliferation in the Fovea With OCT Angiography: A Misnomer. 62
29554391 2018
40
Spectrum of germline RB1 mutations and clinical manifestations in retinoblastoma patients from Thailand. 62
30636860 2018
41
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively. 62
29203899 2017
42
Generation of two H1 hESC sublines carrying a heterozygous and homozygous knock-out of RB1. 62
29246572 2017
43
Retinal astrocytoma in a dog. 62
28878413 2017
44
Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma. 62
28810047 2017
45
Intracameral Chemotherapy (Melphalan) for Aqueous Seeding in Retinoblastoma: Bicameral Injection Technique and Related Toxicity in a Pilot Case Study. 62
28868287 2017
46
Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. 62
28445155 2017
47
CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. 62
27474370 2017
48
SOLITARY CIRCUMSCRIBED "PEARL WHITE" RETINAL MASS (SO-CALLED RETINAL ASTROCYTIC PROLIFERATION) RESIDES IN DEEP RETINA OR BENEATH RETINA: FINDINGS ON MULTIMODAL IMAGING IN 4 CASES. 62
26752524 2017
49
Epigenetic regulation of human retinoblastoma. 62
27639385 2016
50
Kif14 overexpression accelerates murine retinoblastoma development. 62
27270502 2016

Variations for Retinal Cancer

Cosmic variations for Retinal Cancer:

8 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM86647435 RB1 eye,retina,retinoblastoma,NS c.2106+2T>G p.? 13:48459835-48459835 9
2 COSM86634466 RB1 eye,retina,retinoblastoma,NS c.380+1G>T p.? 13:48342715-48342715 9
3 COSM86624550 RB1 eye,retina,retinoblastoma,NS c.1333C>T p.R445* 13:48379594-48379594 9
4 COSM86651352 RB1 eye,retina,retinoblastoma,NS c.1421G>A p.S474N 13:48380084-48380084 9
5 COSM86624126 RB1 eye,retina,retinoblastoma,NS c.751C>T p.R251* 13:48362847-48362847 9
6 COSM86624950 RB1 eye,retina,retinoblastoma,NS c.1183C>T p.Q395* 13:48373460-48373460 9
7 COSM86626226 RB1 eye,retina,retinoblastoma,NS c.958C>T p.R320* 13:48367512-48367512 9
8 COSM86647609 RB1 eye,retina,retinoblastoma,NS c.1960+2T>C p.? 13:48456351-48456351 9
9 COSM86625405 RB1 eye,retina,retinoblastoma,NS c.1666C>T p.R556* 13:48381414-48381414 9
10 COSM86626205 RB1 eye,retina,retinoblastoma,NS c.1363C>T p.R455* 13:48379624-48379624 9
11 COSM86628490 RB1 eye,retina,retinoblastoma,NS c.763C>T p.R255* 13:48362859-48362859 9
12 COSM86642443 RB1 eye,retina,retinoblastoma,NS c.2527G>T p.E843* 13:48476707-48476707 9
13 COSM86636835 RB1 eye,retina,retinoblastoma,NS c.2326-2A>C p.? 13:48465203-48465203 9
14 COSM86633737 RB1 eye,retina,retinoblastoma,NS c.967G>T p.E323* 13:48367521-48367521 9
15 COSM86624252 RB1 eye,retina,retinoblastoma,NS c.1215+1G>A p.? 13:48373493-48373493 9
16 COSM86631349 RB1 eye,retina,retinoblastoma,NS c.2158A>T p.K720* 13:48463782-48463782 9
17 COSM86627680 RB1 eye,retina,retinoblastoma,NS c.1166T>A p.L389* 13:48373443-48373443 9
18 COSM86638492 RB1 eye,retina,retinoblastoma,NS c.1216-2A>G p.? 13:48376916-48376916 9
19 COSM86629052 RB1 eye,retina,retinoblastoma,NS c.1961-1G>A p.? 13:48459687-48459687 9
20 COSM86640644 RB1 eye,retina,retinoblastoma,NS c.1467C>A p.C489* 13:48380210-48380210 9
21 COSM86635450 RB1 eye,retina,retinoblastoma,NS c.2053C>T p.Q685* 13:48459780-48459780 9
22 COSM86637950 RB1 eye,retina,retinoblastoma,NS c.265-2A>C p.? 13:48342597-48342597 9
23 COSM86629160 RB1 eye,retina,retinoblastoma,NS c.409G>T p.E137* 13:48345108-48345108 9
24 COSM86624395 RB1 eye,retina,retinoblastoma,NS c.2520+4A>G p.? 13:48473394-48473394 9
25 COSM86640590 RB1 eye,retina,retinoblastoma,NS c.1891C>T p.Q631* 13:48456280-48456280 9
26 COSM86656361 RB1 eye,retina,retinoblastoma,NS c.982A>C p.N328H 13:48367536-48367536 9
27 COSM86630951 RB1 eye,retina,retinoblastoma,NS c.1654C>T p.R552* 13:48381402-48381402 9
28 COSM86631559 RB1 eye,retina,retinoblastoma,NS c.1049+1G>T p.? 13:48367604-48367604 9
29 COSM86632900 RB1 eye,retina,retinoblastoma,NS c.2063T>C p.L688P 13:48459790-48459790 9
30 COSM150688162 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 9
31 COSM86649095 RB1 eye,retina,retinoblastoma,NS c.2106+1G>T p.? 13:48459834-48459834 9
32 COSM86626876 RB1 eye,retina,retinoblastoma,NS c.2206C>T p.Q736* 13:48463830-48463830 9
33 COSM86637333 RB1 eye,retina,retinoblastoma,NS c.341C>A p.S114* 13:48342675-48342675 9
34 COSM86632739 RB1 eye,retina,retinoblastoma,NS c.1960+1G>A p.? 13:48456350-48456350 9
35 COSM86630352 RB1 eye,retina,retinoblastoma,NS c.862-5T>G p.? 13:48364889-48364889 9
36 COSM86632080 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 9
37 COSM86654450 RB1 eye,retina,retinoblastoma,NS c.2152G>A p.D718N 13:48463776-48463776 9
38 COSM86640621 RB1 eye,retina,retinoblastoma,NS c.1389+1G>C p.? 13:48379651-48379651 9
39 COSM86648958 RB1 eye,retina,retinoblastoma,NS c.1494T>A p.Y498* 13:48380237-48380237 9
40 COSM87132285 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 9
41 COSM148932691 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 9
42 COSM91859716 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 9
43 COSM87804005 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 9
44 COSM87804055 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 9
45 COSM134990158 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 9
46 COSM134614922 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 9
47 COSM134990112 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 9
48 COSM134614978 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 9
49 COSM91859752 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 9

Expression for Retinal Cancer

Search GEO for disease gene expression data for Retinal Cancer.

Pathways for Retinal Cancer

Pathways related to Retinal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 APC CCND1 CDK2 CDK4 CDKN2A E2F1
2
Show member pathways
13.82 TP53 RB1 H2AC18 E2F1 CDKN2A CDK4
3 13.8 TP53 RBL1 KDM4C H2AC18 E2F1 CDK4
4
Show member pathways
13.79 CCND1 CDK2 CDK4 CDKN2A E2F1 H2AC18
5
Show member pathways
13.55 TP53 RBL1 RB1 H2AC18 E2F1 CDKN2A
6
Show member pathways
13.49 APC CCND1 CDK2 CDK4 CDKN2A E2F1
7
Show member pathways
12.83 TP53 RB1 H2AC18 E2F1 CDKN2A CDK4
8
Show member pathways
12.81 APC CCND1 CDK4 CDKN2A E2F1 RB1
9 12.79 TP53 E2F1 CDKN2A CDK4 CDK2 CCND1
10
Show member pathways
12.7 CCND1 CDK2 CDK4 E2F1 RB1 RBL1
11 12.61 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
12
Show member pathways
12.58 RBL1 RB1 E2F1 CDKN2A CDK4 CDK2
13
Show member pathways
12.57 CCND1 CDK2 CDK4 CDKN2A E2F1 RB1
14
Show member pathways
12.56 APC CCND1 CDK4 E2F1 RB1 TP53
15
Show member pathways
12.49 RB1 E2F1 CDKN2A CDK4 CDK2 CCND1
16 12.4 APC CCND1 CDK2 CDK4 E2F1 RB1
17
Show member pathways
12.32 TP53 RB1 E2F1 CDK4 CDK2 CCND1
18
Show member pathways
12.31 TP53 RB1 E2F1 CDK4 CDK2 CCND1
19 12.24 TP53 RB1 E2F1 CDK4 CDK2 CCND1
20
Show member pathways
12.18 TP53 CDKN2A CDK4 CCND1
21 12.1 TP53 RB1 E2F1 APC
22 12.07 CCND1 CDK2 CDK4 E2F1 RB1 TP53
23
Show member pathways
12.02 CCND1 CDK2 CDK4 CDKN2A E2F1 RB1
24 12.01 TP53 RB1 E2F1 CDKN2A
25
Show member pathways
11.99 TP53 RBL1 E2F1 CDK2
26
Show member pathways
11.99 RB1 E2F1 CDK4 CCND1 APC
27 11.97 TP53 RB1 E2F1 CDK4 CDK2 CCND1
28
Show member pathways
11.95 CCND1 CDK2 CDK4 E2F1 MIR20A RB1
29 11.92 TP53 CCND1 APC
30
Show member pathways
11.91 TP53 E2F1 CDKN2A
31
Show member pathways
11.87 RBL1 E2F1 CDK2
32
Show member pathways
11.87 MIR17 MIR199A1 MIR20A MIR9-1
33 11.87 TP53 RB1 E2F1 CDK4 CDK2 CCND1
34
Show member pathways
11.83 TP53 RB1 E2F1
35 11.82 TP53 E2F1 CDK2
36 11.82 CDK2 CDKN2A E2F1 RB1 RBL1
37
Show member pathways
11.82 TP53 RBL1 RB1 E2F1 CDKN2A CDK4
38 11.8 TP53 RB1 E2F1 CDKN2A CDK2
39
Show member pathways
11.78 TP53 CDKN2A CDK2
40 11.77 TP53 RB1 E2F1 CDKN2A CDK4 CCND1
41 11.76 CDKN2A CCND1 APC
42 11.76 TP53 RBL1 CDK4 CCND1
43 11.74 TP53 CDKN2A CCND1
44 11.71 RB1 E2F1 CDKN2A CDK4 CDK2
45 11.68 MIR9-1 MIR21 MIR199A1
46 11.68 KDM4C CDKN2A CCND1
47 11.67 TP53 MIR21 MIR20A MIR17 E2F1 CCND1
48 11.65 RB1 CDK4 CDK2
49
Show member pathways
11.65 TP53 CCND1 APC
50 11.64 RB1 CDK4 CCND1

GO Terms for Retinal Cancer

Cellular components related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulator complex GO:0005667 9.9 CDK2 CDK4 E2F1 RB1 RBL1 TP53
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.85 CDK4 CDK2 CCND1
3 Rb-E2F complex GO:0035189 9.62 RB1 E2F1
4 intracellular organelle GO:0043229 9.58 RBL1 RB1 KDM4C
5 cyclin D1-CDK4 complex GO:0097128 9.56 CDK4 CCND1
6 RISC complex GO:0016442 9.53 MIR9-1 MIR675 MIR361 MIR21 MIR20A MIR199A1
7 extracellular vesicle GO:1903561 9.35 MIR34A MIR21 MIR20A MIR17 MIR125A

Biological processes related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.28 TP53 RB1 MIR9-1 MIR21 CDKN2A APC
2 positive regulation of apoptotic process GO:0043065 10.26 TP53 MIR21 E2F1 CDKN2A APC
3 positive regulation of gene expression GO:0010628 10.19 TP53 MIR34A MIR21 MIR17 MIR125A E2F1
4 miRNA-mediated gene silencing GO:0035195 10.19 MIR125A MIR17 MIR199A1 MIR20A MIR21 MIR34A
5 Ras protein signal transduction GO:0007265 10.18 CDK2 CDKN2A RB1 TP53
6 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 10.13 RBL1 RB1 APC
7 cell cycle GO:0007049 10.13 TP53 RBL1 RB1 E2F1 CDKN2A CDK4
8 cellular response to hypoxia GO:0071456 10.11 E2F1 MIR17 MIR34A TP53
9 G1/S transition of mitotic cell cycle GO:0000082 9.97 RB1 E2F1 CDK4 CDK2 CCND1
10 negative regulation of DNA-binding transcription factor activity GO:0043433 9.95 E2F1 MIR125A MIR199A1 MIR9-1 RB1
11 mitotic G1 DNA damage checkpoint signaling GO:0031571 9.93 TP53 CDK2 CCND1
12 negative regulation of gene expression GO:0010629 9.93 MIR125A MIR17 MIR199A1 MIR20A MIR21 MIR34A
13 regulation of lipid kinase activity GO:0043550 9.92 RBL1 RB1
14 negative regulation of angiogenesis GO:0016525 9.92 MIR125A MIR21 MIR34A MIR361
15 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.91 RB1 E2F1
16 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.82 MIR21 MIR20A MIR17
17 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.81 MIR17 MIR34A TP53
18 negative regulation of protein serine/threonine kinase activity GO:0071901 9.8 RB1 MIR34A MIR20A
19 regulation of cell cycle GO:0051726 9.8 TP53 RBL1 RB1 MIR34A E2F1 CDKN2A
20 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.79 MIR361 MIR20A MIR199A1
21 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.78 MIR9-1 MIR21 MIR20A MIR17
22 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.77 MIR21 MIR20A MIR199A1
23 negative regulation of mitotic cell cycle GO:0045930 9.77 TP53 RB1 MIR21
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.76 MIR675 MIR21 MIR17
25 re-entry into mitotic cell cycle GO:0000320 9.74 MIR199A1 CCND1
26 negative regulation of sprouting angiogenesis GO:1903671 9.72 MIR34A MIR20A MIR17
27 positive regulation of connective tissue replacement GO:1905205 9.66 MIR34A MIR199A1
28 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.64 MIR21 MIR17
29 positive regulation of metalloendopeptidase activity GO:1904685 9.63 MIR21 MIR17
30 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.56 MIR20A MIR17
31 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.54 MIR20A MIR199A1 MIR17
32 negative regulation of superoxide dismutase activity GO:1901670 9.52 MIR675 MIR21
33 negative regulation of vascular endothelial growth factor production GO:1904046 9.1 MIR361 MIR34A MIR20A MIR199A1 MIR17 MIR125A

Molecular functions related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 9.61 MIR9-1 MIR675 MIR361 MIR34A MIR21 MIR20A
2 disordered domain specific binding GO:0097718 9.55 TP53 RB1 CDKN2A
3 mRNA 3'-UTR binding GO:0003730 9.36 TP53 MIR9-1 MIR675 MIR361 MIR34A MIR21

Sources for Retinal Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
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29 HMDB
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31 ICD10
32 ICD10 via Orphanet
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56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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