MCID: RTN015
MIFTS: 49

Retinal Cancer

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Cancer

MalaCards integrated aliases for Retinal Cancer:

Name: Retinal Cancer 12 15 17
Malignant Neoplasm of Retina 12 70
Retinal Neoplasms 44 70
Malignant Retinal Neoplasm 12
Malignant Tumor of Retina 12
Neoplasm of Retina 12
Retinal Neoplasm 17
Retinal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4645
ICD9CM 34 190.5
MeSH 44 D019572
NCIt 50 C3216 C4800
SNOMED-CT 67 127002001 93987004
ICD10 32 C69.2
UMLS 70 C0024622 C0524801

Summaries for Retinal Cancer

MalaCards based summary : Retinal Cancer, also known as malignant neoplasm of retina, is related to retinoblastoma and retinal vascular disease. An important gene associated with Retinal Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ERK Signaling and Cell Cycle, Mitotic. The drugs Etoposide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,... more...

Related Diseases for Retinal Cancer

Diseases related to Retinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)
# Related Disease Score Top Affiliating Genes
1 retinoblastoma 32.1 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2 retinal vascular disease 30.4 MIR199A1 MIR17 H2AC18 CRYAA
3 osteogenic sarcoma 30.2 TP53 RB1 E2F4 E2F1 CDKN2A CDK4
4 malignant astrocytoma 30.2 TP53 MIR9-1 MIR199A1 MIR17 MIR125A KDM4C
5 vulvar adenocarcinoma 10.6 TP53 RB1
6 esophageal leukoplakia 10.6 TP53 CCND1
7 urinary bladder inverted papilloma 10.6 RB1 CDKN2A
8 ring chromosome 7 10.6 TP53 CDK4
9 cecal benign neoplasm 10.6 RBL1 CDKN2A CDK2
10 cecum adenoma 10.6 RBL1 CDKN2A CDK2
11 mediastinum liposarcoma 10.6 CDKN2A CDK4
12 esophagus verrucous carcinoma 10.6 TP53 CDKN2A CCND1
13 anal squamous cell carcinoma 10.6 TP53 CDKN2A APC
14 suppressor of tumorigenicity 3 10.6 TP53 RB1 CDKN2A
15 peritoneum cancer 10.6 TP53 H2AC18 CDKN2A
16 anus cancer 10.6 TP53 H2AC18 CDKN2A
17 cardiovascular organ benign neoplasm 10.6 TP53 KDM4C H2AC18 APC
18 ischemic fasciitis 10.6 CDKN2A CDK4 CCND1
19 heart valve disease 10.6 MIR675 MIR199A1 MIR17 H2AC18
20 diffuse astrocytoma 10.6 TP53 KDM4C H2AC18
21 skeletal muscle cancer 10.6 TP53 MIR675 MIR199A1 H2AC18
22 b-lymphoblastic leukemia/lymphoma with t 10.6 RB1 APC
23 connective tissue benign neoplasm 10.6 TP53 H2AC18 CDK4
24 uterus carcinoma in situ 10.6 TP53 RB1 CDKN2A
25 bone squamous cell carcinoma 10.6 TP53 CDKN2A CCND1
26 cervix uteri carcinoma in situ 10.6 TP53 RB1 CDKN2A
27 anogenital venereal wart 10.6 TP53 RB1 H2AC18 CDKN2A
28 pancreatic foamy gland adenocarcinoma 10.6 TP53 CCND1
29 testicular disease 10.6 TP53 MIR199A1 KDM4C H2AC18
30 laryngeal benign neoplasm 10.6 TP53 CDKN2A CCND1
31 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
32 endocrine organ benign neoplasm 10.6 TP53 MIR199A1 KDM4C H2AC18
33 pleural cancer 10.5 TP53 MIR17 H2AC18 CDKN2A
34 central nervous system benign neoplasm 10.5 TP53 KDM4C H2AC18
35 undifferentiated embryonal sarcoma of the liver 10.5 TP53 CDK4
36 tonsil cancer 10.5 TP53 MIR199A1 H2AC18 CDKN2A
37 ovary adenocarcinoma 10.5 TP53 MIR17 H2AC18 CDKN2A
38 adenoma 10.5 TP53 CDKN2A CCND1 APC
39 fetal alcohol spectrum disorder 10.5 MIR9-1 KDM4C H2AC18
40 gliomatosis cerebri 10.5 TP53 RB1 CDKN2A
41 respiratory system benign neoplasm 10.5 TP53 H2AC18 CDKN2A CCND1
42 pediatric liposarcoma 10.5 TP53 CDK4
43 prostate squamous cell carcinoma 10.5 TP53 CDKN2A CDK6
44 mature t-cell and nk-cell lymphoma 10.5 TP53 MIR199A1 MIR17 KDM4C H2AC18
45 lung adenoma 10.5 TP53 H2AC18 CDKN2A CDK2
46 nodular malignant melanoma 10.5 TP53 CDKN2A CDK4 CCND1
47 fetal alcohol syndrome 10.5 MIR9-1 KDM4C H2AC18
48 autoimmune disease of musculoskeletal system 10.5 MIR199A1 MIR17 MIR125A H2AC18
49 thymus gland disease 10.5 TP53 MIR125A H2AC18
50 chromosomal deletion syndrome 10.5 MIR9-1 MIR17 KDM4C H2AC18

Graphical network of the top 20 diseases related to Retinal Cancer:



Diseases related to Retinal Cancer

Symptoms & Phenotypes for Retinal Cancer

GenomeRNAi Phenotypes related to Retinal Cancer according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.05 APC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-134 10.05 CCND1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-144 10.05 CDK6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-150 10.05 KDM4C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.05 CCND1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.05 CDK6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.05 CDK6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.05 RB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.05 RB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-181 10.05 RB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.05 KDM4C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.05 APC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.05 APC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-209 10.05 KDM4C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.05 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.05 CCND1 RB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.05 CCND1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.05 CCND1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.05 RB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.05 RB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.05 CDK6
22 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.05 CDK6
23 Increased shRNA abundance (Z-score > 2) GR00366-A-72 10.05 KDM4C
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.05 CDK6
25 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 9.02 APC CDK2 CDK4 CDK6 RBL1

MGI Mouse Phenotypes related to Retinal Cancer:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
2 cardiovascular system MP:0005385 10.28 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
3 endocrine/exocrine gland MP:0005379 10.23 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
4 hematopoietic system MP:0005397 10.21 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
5 embryo MP:0005380 10.18 APC CDK2 CDK4 CDK6 CDKN2A E2F1
6 immune system MP:0005387 10.18 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
7 digestive/alimentary MP:0005381 10.15 APC CCND1 CDK4 CDKN2A E2F1 E2F4
8 craniofacial MP:0005382 10.11 APC CCND1 CDK4 E2F1 E2F4 RB1
9 integument MP:0010771 10.11 APC CCND1 CDK2 CDK4 CDKN2A E2F1
10 neoplasm MP:0002006 9.93 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
11 liver/biliary system MP:0005370 9.92 APC CDK2 CDK4 CDK6 CDKN2A RB1
12 muscle MP:0005369 9.91 APC CDK2 CDK4 CDK6 CDKN2A E2F1
13 reproductive system MP:0005389 9.7 APC CCND1 CDK2 CDK4 CDK6 CDKN2A
14 vision/eye MP:0005391 9.32 APC CCND1 CDK2 CDK4 CDK6 CDKN2A

Drugs & Therapeutics for Retinal Cancer

Drugs for Retinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
4
Mesna Approved, Investigational Phase 3 3375-50-6 598
5
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
6
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Lenograstim Approved, Investigational Phase 3 135968-09-1
9 Tubulin Modulators Phase 3
10 Etoposide phosphate Phase 3
11 Antimitotic Agents Phase 3
12 Immunosuppressive Agents Phase 3
13 Alkylating Agents Phase 3
14 Immunologic Factors Phase 3
15 Antibiotics, Antitubercular Phase 3
16 topoisomerase I inhibitors Phase 3
17
Liposomal doxorubicin Phase 3 31703
18 Antirheumatic Agents Phase 3
19 Anesthetics Phase 3
20 Anti-Bacterial Agents Phase 3
21
Melphalan Approved Phase 2 148-82-3 4053 460612

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma Completed NCT00179920 Phase 2 Carboplatin;VP-16
3 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)

Search NIH Clinical Center for Retinal Cancer

Cochrane evidence based reviews: retinal neoplasms

Genetic Tests for Retinal Cancer

Anatomical Context for Retinal Cancer

MalaCards organs/tissues related to Retinal Cancer:

40
Retina, Eye, Brain

Publications for Retinal Cancer

Articles related to Retinal Cancer:

(show all 17)
# Title Authors PMID Year
1
Retinoblastoma: Etiology, Modeling, and Treatment. 61
32824373 2020
2
Patient-reported outcome measures for retinoblastoma: a scoping review. 61
32770435 2020
3
Comprehensive characterization of a Canadian cohort of von Hippel-Lindau disease patients. 61
31368132 2019
4
Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. 61
24911651 2014
5
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. 61
23498719 2013
6
Maintenance of retinal cancer stem cell-like properties through long-term serum-free culture from human retinoblastoma. 61
21573498 2011
7
Vascular Recruitment of Human Retinoblastoma Cells by Multi-Cellular Adhesive Interactions with Circulating Leukocytes. 61
25110524 2010
8
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. 61
20335444 2010
9
Are patients with down syndrome predisposed to retinal neoplasms? 61
19941422 2009
10
Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex. 61
15747752 2004
11
Cancer-associated retinopathy during treatment for small-cell lung carcinoma. 61
10435368 1999
12
Developmental basis of retinal-specific induction of cancer by RB mutation. 61
10197588 1999
13
Ocular manifestations of various systemic disorders. 61
10150822 1994
14
Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. 61
8392328 1993
15
Management and monitoring of cancer-associated retinopathy. 61
1310001 1992
16
Retinal tumor induction by ocular inoculation of human adneovirus in 3-day-old rats. 61
1117320 1975
17
[Bilateral retinal cancer in 2 female twins]. 61
5383904 1969

Variations for Retinal Cancer

Cosmic variations for Retinal Cancer:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM86647435 RB1 eye,retina,retinoblastoma,NS c.2106+2T>G p.? 13:48459835-48459835 3
2 COSM86634466 RB1 eye,retina,retinoblastoma,NS c.380+1G>T p.? 13:48342715-48342715 3
3 COSM86624550 RB1 eye,retina,retinoblastoma,NS c.1333C>T p.R445* 13:48379594-48379594 3
4 COSM86651352 RB1 eye,retina,retinoblastoma,NS c.1421G>A p.S474N 13:48380084-48380084 3
5 COSM86624126 RB1 eye,retina,retinoblastoma,NS c.751C>T p.R251* 13:48362847-48362847 3
6 COSM86624950 RB1 eye,retina,retinoblastoma,NS c.1183C>T p.Q395* 13:48373460-48373460 3
7 COSM86626226 RB1 eye,retina,retinoblastoma,NS c.958C>T p.R320* 13:48367512-48367512 3
8 COSM86647609 RB1 eye,retina,retinoblastoma,NS c.1960+2T>C p.? 13:48456351-48456351 3
9 COSM86625405 RB1 eye,retina,retinoblastoma,NS c.1666C>T p.R556* 13:48381414-48381414 3
10 COSM86626205 RB1 eye,retina,retinoblastoma,NS c.1363C>T p.R455* 13:48379624-48379624 3
11 COSM86628490 RB1 eye,retina,retinoblastoma,NS c.763C>T p.R255* 13:48362859-48362859 3
12 COSM86642443 RB1 eye,retina,retinoblastoma,NS c.2527G>T p.E843* 13:48476707-48476707 3
13 COSM86636835 RB1 eye,retina,retinoblastoma,NS c.2326-2A>C p.? 13:48465203-48465203 3
14 COSM86633737 RB1 eye,retina,retinoblastoma,NS c.967G>T p.E323* 13:48367521-48367521 3
15 COSM86624252 RB1 eye,retina,retinoblastoma,NS c.1215+1G>A p.? 13:48373493-48373493 3
16 COSM86631349 RB1 eye,retina,retinoblastoma,NS c.2158A>T p.K720* 13:48463782-48463782 3
17 COSM86627680 RB1 eye,retina,retinoblastoma,NS c.1166T>A p.L389* 13:48373443-48373443 3
18 COSM86638492 RB1 eye,retina,retinoblastoma,NS c.1216-2A>G p.? 13:48376916-48376916 3
19 COSM86629052 RB1 eye,retina,retinoblastoma,NS c.1961-1G>A p.? 13:48459687-48459687 3
20 COSM86640644 RB1 eye,retina,retinoblastoma,NS c.1467C>A p.C489* 13:48380210-48380210 3
21 COSM86635450 RB1 eye,retina,retinoblastoma,NS c.2053C>T p.Q685* 13:48459780-48459780 3
22 COSM86637950 RB1 eye,retina,retinoblastoma,NS c.265-2A>C p.? 13:48342597-48342597 3
23 COSM86629160 RB1 eye,retina,retinoblastoma,NS c.409G>T p.E137* 13:48345108-48345108 3
24 COSM86624395 RB1 eye,retina,retinoblastoma,NS c.2520+4A>G p.? 13:48473394-48473394 3
25 COSM86640590 RB1 eye,retina,retinoblastoma,NS c.1891C>T p.Q631* 13:48456280-48456280 3
26 COSM86656361 RB1 eye,retina,retinoblastoma,NS c.982A>C p.N328H 13:48367536-48367536 3
27 COSM86630951 RB1 eye,retina,retinoblastoma,NS c.1654C>T p.R552* 13:48381402-48381402 3
28 COSM86631559 RB1 eye,retina,retinoblastoma,NS c.1049+1G>T p.? 13:48367604-48367604 3
29 COSM86632900 RB1 eye,retina,retinoblastoma,NS c.2063T>C p.L688P 13:48459790-48459790 3
30 COSM150688162 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
31 COSM86649095 RB1 eye,retina,retinoblastoma,NS c.2106+1G>T p.? 13:48459834-48459834 3
32 COSM86626876 RB1 eye,retina,retinoblastoma,NS c.2206C>T p.Q736* 13:48463830-48463830 3
33 COSM86637333 RB1 eye,retina,retinoblastoma,NS c.341C>A p.S114* 13:48342675-48342675 3
34 COSM86632739 RB1 eye,retina,retinoblastoma,NS c.1960+1G>A p.? 13:48456350-48456350 3
35 COSM86630352 RB1 eye,retina,retinoblastoma,NS c.862-5T>G p.? 13:48364889-48364889 3
36 COSM86632080 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
37 COSM86654450 RB1 eye,retina,retinoblastoma,NS c.2152G>A p.D718N 13:48463776-48463776 3
38 COSM86640621 RB1 eye,retina,retinoblastoma,NS c.1389+1G>C p.? 13:48379651-48379651 3
39 COSM86648958 RB1 eye,retina,retinoblastoma,NS c.1494T>A p.Y498* 13:48380237-48380237 3
40 COSM87132285 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
41 COSM148932691 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
42 COSM91859716 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
43 COSM87804005 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
44 COSM87804055 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
45 COSM134990158 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
46 COSM134614922 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
47 COSM134990112 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
48 COSM134614978 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
49 COSM91859752 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3

Expression for Retinal Cancer

Search GEO for disease gene expression data for Retinal Cancer.

Pathways for Retinal Cancer

Pathways related to Retinal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2
Show member pathways
13.54 TP53 RBL1 RB1 H2AC18 E2F4 E2F1
3
Show member pathways
13.25 TP53 RB1 E2F1 CDK6 CDK4 CDK2
4
Show member pathways
13.23 TP53 RB1 H2AC18 E2F1 CDKN2A CDK6
5
Show member pathways
13.12 TP53 RBL1 RB1 E2F1 CDK6 CDK4
6
Show member pathways
13.04 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
7
Show member pathways
13.03 RB1 E2F1 CDKN2A CDK6 CDK4 CDK2
8
Show member pathways
13.02 TP53 RBL1 E2F4 E2F1 CDKN2A CDK2
9
Show member pathways
13 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
10 12.97 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
11
Show member pathways
12.93 TP53 RB1 E2F1 CDK6 CDK4 CDK2
12
Show member pathways
12.87 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
13
Show member pathways
12.84 TP53 RBL1 RB1 E2F4 E2F1 CDK4
14
Show member pathways
12.82 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
15
Show member pathways
12.72 RB1 CDK6 CDK4 CDK2 CCND1
16
Show member pathways
12.65 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
17 12.63 TP53 RB1 E2F1 CDKN2A CDK6 CDK4
18 12.59 TP53 MIR9-1 MIR199A1 MIR17 MIR125A E2F1
19 12.49 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
20
Show member pathways
12.48 TP53 RB1 MIR17 E2F1 CDKN2A CDK6
21 12.47 TP53 RBL1 RB1 E2F4 E2F1 CDK6
22 12.44 TP53 RBL1 RB1 CDKN2A CDK6 CDK4
23
Show member pathways
12.4 TP53 RB1 E2F4 E2F1 CDK4 CDK2
24
Show member pathways
12.39 TP53 RB1 E2F4 E2F1 CDK4 CDK2
25
Show member pathways
12.38 TP53 RB1 H2AC18 CDK2
26
Show member pathways
12.37 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
27
Show member pathways
12.34 RB1 E2F4 E2F1 CDKN2A CDK6 CDK4
28 12.31 TP53 RB1 E2F1 CDK4 CDK2 CCND1
29 12.24 TP53 E2F4 CCND1 APC
30 12.18 TP53 RB1 E2F1 CDK4 CDK2 CCND1
31 12.13 TP53 RBL1 E2F4 CCND1
32 12.13 RBL1 RB1 E2F4 E2F1
33 12.07 TP53 CDKN2A CCND1 APC
34
Show member pathways
12.07 TP53 RBL1 E2F4 E2F1 CDK2
35 12.03 TP53 RB1 E2F1 CDKN2A
36 12.02 TP53 RB1 E2F1 CDK6 CDK4 CDK2
37 11.97 TP53 RB1 E2F1 CDK6 CDK4 CDK2
38
Show member pathways
11.92 TP53 RB1 E2F4 E2F1
39 11.91 RBL1 RB1 E2F4 E2F1 CDK2
40 11.9 TP53 RB1 E2F4 E2F1 CDKN2A CDK6
41 11.88 TP53 RB1 E2F1 CDKN2A CDK4 CCND1
42 11.85 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
43 11.82 RB1 E2F1 CDK4 CDK2
44 11.82 TP53 RB1 E2F1 CDKN2A CDK2
45 11.8 RBL1 CDK4 CDK2
46
Show member pathways
11.79 RBL1 RB1 E2F4 E2F1 CDK6 CDK4
47
Show member pathways
11.77 TP53 CDKN2A CDK2
48 11.72 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
49 11.69 TP53 RB1 CDKN2A CCND1
50 11.68 TP53 E2F1 CDK6 CCND1

GO Terms for Retinal Cancer

Cellular components related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.24 TP53 RBL1 RB1 MIR9-1 KDM4C H2AC18
2 nucleoplasm GO:0005654 9.97 TP53 RBL1 RB1 KDM4C E2F4 E2F1
3 chromatin GO:0000785 9.92 TP53 RBL1 RB1 KDM4C H2AC18 E2F4
4 centrosome GO:0005813 9.8 TP53 E2F1 CDK6 CDK2 APC
5 Rb-E2F complex GO:0035189 9.26 RB1 E2F1
6 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.26 CDK6 CDK4 CDK2 CCND1
7 transcription factor complex GO:0005667 9.17 TP53 RBL1 RB1 E2F4 E2F1 CDK4

Biological processes related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.1 TP53 RBL1 RB1 E2F1 CDK2 CCND1
2 positive regulation of gene expression GO:0010628 10.02 TP53 MIR125A KDM4C E2F1 CDKN2A
3 gene silencing by miRNA GO:0035195 10.01 MIR9-1 MIR675 MIR361 MIR199A1 MIR17 MIR125A
4 cell division GO:0051301 10 RB1 CDK6 CDK4 CDK2 CCND1
5 positive regulation of apoptotic process GO:0043065 9.97 TP53 E2F1 CDKN2A CDK4 APC
6 negative regulation of cell proliferation GO:0008285 9.97 TP53 RB1 MIR9-1 CDKN2A CDK6 APC
7 cell cycle GO:0007049 9.96 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
8 negative regulation of gene expression GO:0010629 9.95 TP53 RBL1 RB1 MIR17 MIR125A
9 regulation of cell proliferation GO:0042127 9.91 TP53 E2F4 CDK6 CDK4
10 cell cycle arrest GO:0007050 9.8 TP53 RB1 CDKN2A CDK6 APC
11 Ras protein signal transduction GO:0007265 9.78 TP53 RB1 CDKN2A CDK2
12 negative regulation of osteoblast differentiation GO:0045668 9.76 MIR9-1 MIR675 CDK6
13 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.76 TP53 E2F4 E2F1 CDK2
14 positive regulation of fibroblast proliferation GO:0048146 9.73 MIR17 E2F1 CDK6 CDK4
15 negative regulation of cellular senescence GO:2000773 9.69 RBL1 MIR17 CDK6
16 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.63 RBL1 RB1 CDKN2A CDK6 CDK4 APC
17 negative regulation of vascular endothelial growth factor production GO:1904046 9.62 MIR361 MIR199A1 MIR17 MIR125A
18 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.61 MIR199A1 MIR17
19 cellular response to xenobiotic stimulus GO:0071466 9.59 RB1 E2F1
20 re-entry into mitotic cell cycle GO:0000320 9.57 MIR199A1 CCND1
21 regulation of lipid kinase activity GO:0043550 9.56 RBL1 RB1
22 mitotic G1 DNA damage checkpoint GO:0031571 9.54 TP53 CDK2 CCND1
23 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.52 RB1 E2F1
24 G1/S transition of mitotic cell cycle GO:0000082 9.5 RB1 E2F1 CDKN2A CDK6 CDK4 CDK2
25 regulation of cell cycle GO:0051726 9.23 TP53 RBL1 RB1 E2F1 CDK6 CDK4

Molecular functions related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.88 TP53 E2F1 CDKN2A CCND1 APC
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.63 MIR9-1 MIR675 MIR361 MIR199A1 MIR17 MIR125A
3 promoter-specific chromatin binding GO:1990841 9.61 TP53 RBL1 E2F4
4 disordered domain specific binding GO:0097718 9.58 TP53 RB1 CDKN2A
5 cyclin binding GO:0030332 9.54 CDK6 CDK4 CDK2
6 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.5 CDK6 CDK4 CDK2
7 transcription factor binding GO:0008134 9.5 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
8 RNA polymerase II CTD heptapeptide repeat kinase activity GO:0008353 9.49 CDK6 CDK4
9 MDM2/MDM4 family protein binding GO:0097371 9.46 TP53 CDKN2A
10 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216 9.43 TP53 E2F4 E2F1
11 mRNA 3'-UTR binding GO:0003730 9.1 TP53 MIR9-1 MIR675 MIR361 MIR17 MIR125A

Sources for Retinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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