MCID: RTN015
MIFTS: 48

Retinal Cancer

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Cancer

MalaCards integrated aliases for Retinal Cancer:

Name: Retinal Cancer 12 15 17
Malignant Neoplasm of Retina 12 71
Retinal Neoplasms 43 71
Malignant Retinal Neoplasm 12
Malignant Tumor of Retina 12
Neoplasm of Retina 12
Retinal Neoplasm 17
Retinal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4645
ICD9CM 34 190.5
MeSH 43 D019572
NCIt 49 C3216 C4800
SNOMED-CT 67 127002001 363465007
ICD10 32 C69.2
UMLS 71 C0024622 C0524801

Summaries for Retinal Cancer

MalaCards based summary : Retinal Cancer, also known as malignant neoplasm of retina, is related to retinoblastoma and familial retinoblastoma. An important gene associated with Retinal Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are ERK Signaling and Cell Cycle, Mitotic. The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and brain, and related phenotypes are cellular and cardiovascular system

Wikipedia : 74 Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,... more...

Related Diseases for Retinal Cancer

Diseases related to Retinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 328)
# Related Disease Score Top Affiliating Genes
1 retinoblastoma 32.9 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2 familial retinoblastoma 30.5 TP53 RBL1 RB1 E2F4 CDKN2A CDK4
3 retinal vascular disease 30.4 MIR199A1 H2AC18 CRYAA
4 osteogenic sarcoma 30.4 TP53 RB1 E2F4 E2F1 CDKN2A CDK4
5 vulvar adenocarcinoma 10.8 TP53 RB1
6 esophageal leukoplakia 10.8 TP53 CCND1
7 urinary bladder inverted papilloma 10.8 RB1 CDKN2A
8 ring chromosome 7 10.8 TP53 CDK4
9 cecal benign neoplasm 10.8 RBL1 CDKN2A CDK2
10 cecum adenoma 10.8 RBL1 CDKN2A CDK2
11 mediastinum liposarcoma 10.8 CDKN2A CDK4
12 anal squamous cell carcinoma 10.8 TP53 CDKN2A APC
13 brain stem cancer 10.8 TP53 KDM4C H2AC18
14 peritoneum cancer 10.8 TP53 H2AC18 CDKN2A
15 esophagus verrucous carcinoma 10.8 TP53 CDKN2A CCND1
16 anus cancer 10.8 TP53 H2AC18 CDKN2A
17 suppressor of tumorigenicity 3 10.8 TP53 RB1 CDKN2A
18 heart valve disease 10.8 MIR675 MIR199A1 MIR17 H2AC18
19 bone osteosarcoma 10.8 TP53 H2AC18 CDK4
20 cardiovascular organ benign neoplasm 10.8 TP53 KDM4C H2AC18 APC
21 fibrillary astrocytoma 10.8 TP53 KDM4C H2AC18 CDKN2A
22 uterus carcinoma in situ 10.8 TP53 RB1 CDKN2A
23 richter's syndrome 10.8 TP53 MIR17 MIR125A
24 cervix uteri carcinoma in situ 10.8 TP53 RB1 CDKN2A
25 bone squamous cell carcinoma 10.8 TP53 CDKN2A CCND1
26 anogenital venereal wart 10.7 TP53 H2AC18 CDKN2A
27 testicular disease 10.7 TP53 MIR199A1 KDM4C H2AC18
28 connective tissue benign neoplasm 10.7 TP53 H2AC18 CDK4
29 thyroid gland follicular carcinoma 10.7 TP53 MIR199A1 MIR17
30 endocrine organ benign neoplasm 10.7 TP53 MIR199A1 KDM4C H2AC18
31 laryngeal benign neoplasm 10.7 TP53 CDKN2A CCND1
32 serous cystadenocarcinoma 10.7 TP53 MIR199A1 CDKN2A
33 prostate squamous cell carcinoma 10.7 TP53 CDKN2A
34 tonsil cancer 10.7 TP53 MIR199A1 H2AC18 CDKN2A
35 pleural cancer 10.7 TP53 MIR17 H2AC18 CDKN2A
36 gliomatosis cerebri 10.7 TP53 RB1 KDM4C CDKN2A
37 inverted papilloma 10.7 TP53 CDKN2A CCND1
38 hereditary melanoma 10.7 CDKN2A CDK4
39 adenoma 10.7 TP53 CDKN2A CCND1 APC
40 skeletal muscle cancer 10.7 TP53 MIR675 MIR199A1 H2AC18 CDK4
41 fetal alcohol spectrum disorder 10.7 MIR9-1 KDM4C H2AC18
42 central nervous system benign neoplasm 10.7 TP53 MIRLET7B KDM4C H2AC18
43 hyperplastic polyposis syndrome 10.7 TP53 APC
44 fetal alcohol syndrome 10.7 MIR9-1 KDM4C H2AC18
45 nodular malignant melanoma 10.7 TP53 CDKN2A CDK4 CCND1
46 colonic benign neoplasm 10.7 TP53 KDM4C H2AC18 CCND1 APC
47 pancreatic foamy gland adenocarcinoma 10.7 TP53 CCND1
48 vulvar intraepithelial neoplasia 10.7 TP53 CDKN2A
49 retinitis pigmentosa 11 10.7 TP53 KDM4C H2AC18 CDKN2A
50 bone inflammation disease 10.7 MIR675 MIR199A1 MIR17 MIR125A H2AC18

Graphical network of the top 20 diseases related to Retinal Cancer:



Diseases related to Retinal Cancer

Symptoms & Phenotypes for Retinal Cancer

MGI Mouse Phenotypes related to Retinal Cancer:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 APC CCND1 CDK2 CDK4 CDKN2A E2F1
2 cardiovascular system MP:0005385 10.25 APC CCND1 CDK2 CDK4 CDKN2A E2F1
3 endocrine/exocrine gland MP:0005379 10.22 APC CCND1 CDK2 CDK4 CDKN2A E2F1
4 hematopoietic system MP:0005397 10.17 APC CCND1 CDK2 CDK4 CDKN2A E2F1
5 digestive/alimentary MP:0005381 10.16 APC CCND1 CDK4 CDKN2A E2F1 E2F4
6 embryo MP:0005380 10.15 APC CDK2 CDK4 CDKN2A E2F1 E2F4
7 immune system MP:0005387 10.14 APC CCND1 CDK2 CDK4 CDKN2A E2F1
8 craniofacial MP:0005382 10.13 APC CCND1 CDK4 E2F1 E2F4 RB1
9 integument MP:0010771 10.11 APC CCND1 CDK2 CDK4 CDKN2A E2F1
10 neoplasm MP:0002006 10 APC CCND1 CDK2 CDK4 CDKN2A E2F1
11 hearing/vestibular/ear MP:0005377 9.93 APC E2F1 E2F4 RB1 RBL1 TP53
12 muscle MP:0005369 9.92 APC CDK2 CDK4 CDKN2A E2F1 RB1
13 reproductive system MP:0005389 9.65 APC CCND1 CDK2 CDK4 CDKN2A E2F1
14 pigmentation MP:0001186 9.55 APC CDK4 CDKN2A RB1 TP53
15 vision/eye MP:0005391 9.28 APC CCND1 CDK2 CDK4 CDKN2A E2F1

Drugs & Therapeutics for Retinal Cancer

Drugs for Retinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
2
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
5
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
6
Mesna Approved, Investigational Phase 3 3375-50-6 598
7
Lenograstim Approved, Investigational Phase 3 135968-09-1
8
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
9 Etoposide phosphate Phase 3
10 Immunologic Factors Phase 3
11 Immunosuppressive Agents Phase 3
12 Alkylating Agents Phase 3
13 Tubulin Modulators Phase 3
14 Antimitotic Agents Phase 3
15 topoisomerase I inhibitors Phase 3
16 Antibiotics, Antitubercular Phase 3
17
Liposomal doxorubicin Phase 3 31703
18 Anesthetics Phase 3
19 Antirheumatic Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21
Melphalan Approved Phase 2 148-82-3 460612 4053

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma Unknown status NCT00179920 Phase 2 Carboplatin;VP-16
3 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)
4 Phase I Sustained-Release Topotecan Episcleral Plaque (Chemoplaque) for Retinoblastoma Not yet recruiting NCT04428879 Phase 1 Topotecan Episcleral Plaque
5 Use of Eylea for the Treatment of an Optic Nerve Hemangioma No longer available NCT01714115 Aflibercept

Search NIH Clinical Center for Retinal Cancer

Cochrane evidence based reviews: retinal neoplasms

Genetic Tests for Retinal Cancer

Anatomical Context for Retinal Cancer

MalaCards organs/tissues related to Retinal Cancer:

40
Retina, Eye, Brain, Lung

Publications for Retinal Cancer

Articles related to Retinal Cancer:

(show all 15)
# Title Authors PMID Year
1
Comprehensive characterization of a Canadian cohort of von Hippel-Lindau disease patients. 61
31368132 2019
2
Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. 61
24911651 2014
3
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. 61
23498719 2013
4
Maintenance of retinal cancer stem cell-like properties through long-term serum-free culture from human retinoblastoma. 61
21573498 2011
5
Vascular Recruitment of Human Retinoblastoma Cells by Multi-Cellular Adhesive Interactions with Circulating Leukocytes. 61
25110524 2010
6
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. 61
20335444 2010
7
Are patients with down syndrome predisposed to retinal neoplasms? 61
19941422 2009
8
Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex. 61
15747752 2004
9
Cancer-associated retinopathy during treatment for small-cell lung carcinoma. 61
10435368 1999
10
Developmental basis of retinal-specific induction of cancer by RB mutation. 61
10197588 1999
11
Ocular manifestations of various systemic disorders. 61
10150822 1994
12
Intraperitoneal cultivation of small-cell carcinoma induces expression of the retinal cancer-associated retinopathy antigen. 61
8392328 1993
13
Management and monitoring of cancer-associated retinopathy. 61
1310001 1992
14
Retinal tumor induction by ocular inoculation of human adneovirus in 3-day-old rats. 61
1117320 1975
15
[Bilateral retinal cancer in 2 female twins]. 61
5383904 1969

Variations for Retinal Cancer

Cosmic variations for Retinal Cancer:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM86647435 RB1 eye,retina,retinoblastoma,NS c.2106+2T>G p.? 13:48459835-48459835 3
2 COSM86634466 RB1 eye,retina,retinoblastoma,NS c.380+1G>T p.? 13:48342715-48342715 3
3 COSM86624550 RB1 eye,retina,retinoblastoma,NS c.1333C>T p.R445* 13:48379594-48379594 3
4 COSM86651352 RB1 eye,retina,retinoblastoma,NS c.1421G>A p.S474N 13:48380084-48380084 3
5 COSM86624126 RB1 eye,retina,retinoblastoma,NS c.751C>T p.R251* 13:48362847-48362847 3
6 COSM86624950 RB1 eye,retina,retinoblastoma,NS c.1183C>T p.Q395* 13:48373460-48373460 3
7 COSM86626226 RB1 eye,retina,retinoblastoma,NS c.958C>T p.R320* 13:48367512-48367512 3
8 COSM86647609 RB1 eye,retina,retinoblastoma,NS c.1960+2T>C p.? 13:48456351-48456351 3
9 COSM86625405 RB1 eye,retina,retinoblastoma,NS c.1666C>T p.R556* 13:48381414-48381414 3
10 COSM86626205 RB1 eye,retina,retinoblastoma,NS c.1363C>T p.R455* 13:48379624-48379624 3
11 COSM86628490 RB1 eye,retina,retinoblastoma,NS c.763C>T p.R255* 13:48362859-48362859 3
12 COSM86642443 RB1 eye,retina,retinoblastoma,NS c.2527G>T p.E843* 13:48476707-48476707 3
13 COSM86636835 RB1 eye,retina,retinoblastoma,NS c.2326-2A>C p.? 13:48465203-48465203 3
14 COSM86633737 RB1 eye,retina,retinoblastoma,NS c.967G>T p.E323* 13:48367521-48367521 3
15 COSM86624252 RB1 eye,retina,retinoblastoma,NS c.1215+1G>A p.? 13:48373493-48373493 3
16 COSM86631349 RB1 eye,retina,retinoblastoma,NS c.2158A>T p.K720* 13:48463782-48463782 3
17 COSM86627680 RB1 eye,retina,retinoblastoma,NS c.1166T>A p.L389* 13:48373443-48373443 3
18 COSM86638492 RB1 eye,retina,retinoblastoma,NS c.1216-2A>G p.? 13:48376916-48376916 3
19 COSM86629052 RB1 eye,retina,retinoblastoma,NS c.1961-1G>A p.? 13:48459687-48459687 3
20 COSM86640644 RB1 eye,retina,retinoblastoma,NS c.1467C>A p.C489* 13:48380210-48380210 3
21 COSM86635450 RB1 eye,retina,retinoblastoma,NS c.2053C>T p.Q685* 13:48459780-48459780 3
22 COSM86637950 RB1 eye,retina,retinoblastoma,NS c.265-2A>C p.? 13:48342597-48342597 3
23 COSM86629160 RB1 eye,retina,retinoblastoma,NS c.409G>T p.E137* 13:48345108-48345108 3
24 COSM86624395 RB1 eye,retina,retinoblastoma,NS c.2520+4A>G p.? 13:48473394-48473394 3
25 COSM86640590 RB1 eye,retina,retinoblastoma,NS c.1891C>T p.Q631* 13:48456280-48456280 3
26 COSM86656361 RB1 eye,retina,retinoblastoma,NS c.982A>C p.N328H 13:48367536-48367536 3
27 COSM86630951 RB1 eye,retina,retinoblastoma,NS c.1654C>T p.R552* 13:48381402-48381402 3
28 COSM86631559 RB1 eye,retina,retinoblastoma,NS c.1049+1G>T p.? 13:48367604-48367604 3
29 COSM86632900 RB1 eye,retina,retinoblastoma,NS c.2063T>C p.L688P 13:48459790-48459790 3
30 COSM86649095 RB1 eye,retina,retinoblastoma,NS c.2106+1G>T p.? 13:48459834-48459834 3
31 COSM86626876 RB1 eye,retina,retinoblastoma,NS c.2206C>T p.Q736* 13:48463830-48463830 3
32 COSM86637333 RB1 eye,retina,retinoblastoma,NS c.341C>A p.S114* 13:48342675-48342675 3
33 COSM86632739 RB1 eye,retina,retinoblastoma,NS c.1960+1G>A p.? 13:48456350-48456350 3
34 COSM86630352 RB1 eye,retina,retinoblastoma,NS c.862-5T>G p.? 13:48364889-48364889 3
35 COSM86632080 RB1 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
36 COSM86654450 RB1 eye,retina,retinoblastoma,NS c.2152G>A p.D718N 13:48463776-48463776 3
37 COSM86640621 RB1 eye,retina,retinoblastoma,NS c.1389+1G>C p.? 13:48379651-48379651 3
38 COSM86648958 RB1 eye,retina,retinoblastoma,NS c.1494T>A p.Y498* 13:48380237-48380237 3
39 COSM87132285 PIK3CA eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
40 COSM87804005 KRAS eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
41 COSM87804055 KRAS eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
42 COSM91859716 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
43 COSM134990158 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
44 COSM134614922 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
45 COSM134990112 eye,retina,retinoblastoma,NS c.35G>A p.G12D 12:25245350-25245350 3
46 COSM148932691 eye,retina,retinoblastoma,NS c.1634A>G p.E545G 3:179218304-179218304 3
47 COSM134614978 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3
48 COSM150688162 eye,retina,retinoblastoma,NS c.160G>T p.E54* 13:48307302-48307302 3
49 COSM91859752 eye,retina,retinoblastoma,NS c.35G>T p.G12V 12:25245350-25245350 3

Expression for Retinal Cancer

Search GEO for disease gene expression data for Retinal Cancer.

Pathways for Retinal Cancer

Pathways related to Retinal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
2
Show member pathways
13.52 TP53 RBL1 RB1 H2AC18 E2F4 E2F1
3
Show member pathways
13.19 TP53 RB1 H2AC18 E2F1 CDKN2A CDK4
4
Show member pathways
13.1 TP53 RBL1 RB1 E2F1 CDK4 CDK2
5
Show member pathways
13.09 TP53 RB1 E2F1 CDK4 CDK2 CCND1
6
Show member pathways
13.01 TP53 RBL1 E2F4 E2F1 CDKN2A CDK2
7
Show member pathways
12.99 RB1 E2F1 CDKN2A CDK4 CDK2 CCND1
8
Show member pathways
12.99 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
9
Show member pathways
12.98 TP53 RB1 E2F1 CDKN2A CDK4 CCND1
10 12.95 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
11
Show member pathways
12.88 TP53 RB1 E2F1 CDK4 CDK2 CCND1
12
Show member pathways
12.86 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
13
Show member pathways
12.79 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
14
Show member pathways
12.79 TP53 RBL1 RB1 E2F4 E2F1 CDK4
15
Show member pathways
12.63 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
16 12.62 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
17
Show member pathways
12.48 RB1 E2F4 E2F1 APC
18 12.48 TP53 RBL1 RB1 E2F4 E2F1 CDK4
19 12.44 TP53 RB1 E2F1 CDKN2A CDK4 CDK2
20
Show member pathways
12.43 TP53 RB1 MIR373 MIR17 E2F1 CDKN2A
21 12.4 TP53 RBL1 RB1 CDKN2A CDK4 CDK2
22
Show member pathways
12.37 TP53 RB1 H2AC18 CDK2
23
Show member pathways
12.37 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
24
Show member pathways
12.36 TP53 RB1 E2F4 E2F1 CDK4 CDK2
25
Show member pathways
12.34 TP53 RB1 E2F4 E2F1 CDK4 CDK2
26
Show member pathways
12.28 RB1 E2F4 E2F1 CDKN2A CDK4 CDK2
27 12.26 TP53 RB1 E2F1 CDK4 CDK2 CCND1
28 12.23 TP53 E2F4 CCND1 APC
29 12.21 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
30 12.13 TP53 RBL1 E2F4 CCND1
31 12.13 TP53 RB1 E2F1 CDK4 CDK2 CCND1
32 12.12 RBL1 RB1 E2F4 E2F1
33 12.1 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
34 12.06 TP53 CDKN2A CCND1 APC
35
Show member pathways
12.06 TP53 RBL1 E2F4 E2F1 CDK2
36 12.02 TP53 RB1 E2F1 CDKN2A
37 11.98 TP53 RB1 E2F1 CDK4 CDK2 CCND1
38 11.93 TP53 RB1 E2F1 CDK4 CDK2 CCND1
39
Show member pathways
11.91 TP53 RB1 E2F4 E2F1
40 11.88 RBL1 RB1 E2F4 E2F1 CDK2
41 11.85 TP53 MIRLET7B MIR9-1 MIR373 MIR199A1 MIR17
42 11.82 RB1 E2F1 CDK4 CDK2
43 11.82 TP53 RB1 E2F1 CDKN2A CDK4 CCND1
44 11.81 TP53 RB1 E2F1 CDKN2A CDK2
45
Show member pathways
11.8 RBL1 RB1 E2F4 E2F1 CDK4 CDK2
46 11.79 RBL1 CDK4 CDK2
47
Show member pathways
11.77 TP53 CDKN2A CDK2
48 11.68 TP53 RB1 CDKN2A CCND1
49 11.67 TP53 MIR373 E2F1 CCND1
50 11.65 RB1 E2F4 CDK2

GO Terms for Retinal Cancer

Cellular components related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.17 TP53 RBL1 RB1 MIR9-1 KDM4C H2AC18
2 nucleoplasm GO:0005654 10.03 TP53 RBL1 RB1 KDM4C E2F4 E2F1
3 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.33 CDK4 CDK2 CCND1
4 transcription factor complex GO:0005667 9.17 TP53 RBL1 RB1 E2F4 E2F1 CDK4
5 Rb-E2F complex GO:0035189 8.96 RB1 E2F1

Biological processes related to Retinal Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.02 TP53 RBL1 RB1 E2F4 E2F1 CDK2
2 positive regulation of gene expression GO:0010628 9.99 TP53 MIR125A KDM4C E2F1 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.98 TP53 RB1 MIR9-1 CDKN2A APC
4 positive regulation of apoptotic process GO:0043065 9.96 TP53 E2F1 CDKN2A CDK4 APC
5 gene silencing by miRNA GO:0035195 9.95 MIRLET7B MIR9-1 MIR675 MIR373 MIR199A1 MIR17
6 negative regulation of gene expression GO:0010629 9.91 TP53 RBL1 RB1 MIR17 MIR125A
7 cell cycle arrest GO:0007050 9.83 TP53 RB1 CDKN2A APC
8 Ras protein signal transduction GO:0007265 9.76 TP53 RB1 CDKN2A CDK2
9 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.73 RBL1 RB1 CDKN2A CDK4
10 positive regulation of fibroblast proliferation GO:0048146 9.72 MIR17 E2F1 CDK4
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.67 TP53 E2F4 E2F1 CDK2
12 G1/S transition of mitotic cell cycle GO:0000082 9.65 RB1 CDKN2A CDK4 CDK2 CCND1
13 replicative senescence GO:0090399 9.61 TP53 CDKN2A
14 cell cycle GO:0007049 9.61 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
15 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.6 MIR199A1 MIR17
16 cellular response to xenobiotic stimulus GO:0071466 9.58 RB1 E2F1
17 re-entry into mitotic cell cycle GO:0000320 9.57 MIR199A1 CCND1
18 regulation of lipid kinase activity GO:0043550 9.54 RBL1 RB1
19 mitotic G1 DNA damage checkpoint GO:0031571 9.5 TP53 CDK2 CCND1
20 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.49 RB1 E2F1
21 negative regulation of vascular endothelial growth factor production GO:1904046 9.46 MIR373 MIR199A1 MIR17 MIR125A
22 regulation of cell cycle GO:0051726 9.23 TP53 RBL1 RB1 E2F4 E2F1 CDK4

Molecular functions related to Retinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TP53 E2F1 CDKN2A CCND1 APC
2 promoter-specific chromatin binding GO:1990841 9.5 TP53 RBL1 E2F4
3 transcription factor binding GO:0008134 9.5 TP53 RBL1 RB1 E2F4 E2F1 CDKN2A
4 RNA polymerase II regulatory region DNA binding GO:0001012 9.4 RBL1 RB1
5 disordered domain specific binding GO:0097718 9.33 TP53 RB1 CDKN2A
6 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216 9.26 E2F4 E2F1
7 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIRLET7B MIR9-1 MIR675 MIR373 MIR199A1 MIR17

Sources for Retinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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