MCID: RTN017
MIFTS: 59

Retinal Detachment

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Detachment

MalaCards integrated aliases for Retinal Detachment:

Name: Retinal Detachment 57 12 29 55 6 43 44 15 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
retinal detachment:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 180050
Disease Ontology 12 DOID:5327
ICD10 33 H33.2 H33.0
ICD9CM 35 361.9
MeSH 44 D012163
NCIt 50 C26874
SNOMED-CT 68 42059000
MedGen 42 C0035305
SNOMED-CT via HPO 69 263681008
UMLS 73 C0035305

Summaries for Retinal Detachment

MedlinePlus : 43 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. It provides the sharp, central vision needed for reading, driving, and seeing fine detail. A retinal detachment lifts or pulls the retina from its normal position. It can occur at any age, but it is more common in people over age 40. It affects men more than women and whites more than African Americans. A retinal detachment is also more likely to occur in people who Are extremely nearsighted Have had a retinal detachment in the other eye Have a family history of retinal detachment Have had cataract surgery Have other eye diseases or disorders Have had an eye injury Symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. It may also seem like there is a "curtain" over your field of vision. A retinal detachment is a medical emergency. If not promptly treated, it can cause permanent vision loss. If you have any symptoms, see an eye care professional immediately. Treatment includes different types of surgery. NIH: National Eye Institute

MalaCards based summary : Retinal Detachment is related to persistent hyperplastic primary vitreous, autosomal recessive and persistent hyperplastic primary vitreous. An important gene associated with Retinal Detachment is RHO (Rhodopsin), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Lidocaine and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are retinal detachment and cardiovascular system

OMIM : 57 Primary or spontaneous detachment of the retina occurs due to underlying ocular disease and often involves the vitreous as well as the retina. The precipitating event is formation of a retinal tear or hole, which permits fluid to accumulate under the sensory layers of the retina and creates an intraretinal cleavage that destroys the neurosensory process of visual reception. Vitreoretinal degeneration and tear formation are painless phenomena, and in most cases, significant vitreoretinal pathology is found only after detachment of the retina starts to cause loss of vision or visual field. Without surgical intervention, retinal detachment will almost inevitably lead to total blindness (summary by McNiel and McPherson, 1971). (180050)

Wikipedia : 76 Retinal detachment is a disorder of the eye in which the retina separates from the layer underneath.... more...

Related Diseases for Retinal Detachment

Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)
# Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous, autosomal recessive 33.2 TSPAN12 ATOH7
2 persistent hyperplastic primary vitreous 32.3 TSPAN12 NDP FZD4 ATOH7
3 retinal disease 32.1 RS1 RHO NDP
4 exudative vitreoretinopathy 1 32.1 VEGFA TSPAN12 NDP LRP5 FZD4 CTNNB1
5 exudative vitreoretinopathy 31.9 TSPAN12 NDP LRP5 FZD4 CTNNB1 ATOH7
6 myopia 31.9 VEGFA RHO COL2A1 COL18A1 COL11A1
7 coats disease 31.8 VEGFA TSPAN12 RS1 RHO NDP LRP5
8 donnai-barrow syndrome 31.7 COL2A1 COL18A1 COL11A1
9 retinal perforation 30.6 KCNJ13 COL2A1 COL11A1
10 strabismus 30.5 RS1 CTNNB1 COL2A1 COL11A1
11 microvascular complications of diabetes 1 30.2 VEGFA SERPINF1 GFAP
12 macular dystrophy, dominant cystoid 30.2 VEGFA SERPINF1 CAPN5
13 vitreoretinal degeneration 30.1 KCNJ13 COL2A1 COL18A1 COL11A1
14 osteoporosis-pseudoglioma syndrome 30.0 NDP LRP5 FZD4 CTNNB1
15 norrie disease 29.9 TSPAN12 NDP LRP5 FZD4
16 retinal telangiectasia 29.9 VEGFA TSPAN12 NDP FZD4
17 macular degeneration, age-related, 1 29.6 VEGFA SERPINF1 RHO COL18A1
18 leber congenital amaurosis 29.2 SERPINF1 RHO LRP5 KCNJ13
19 retinitis pigmentosa 28.6 SERPINF1 RS1 RHO GFAP COL18A1 CAPN5
20 stickler syndrome, type i, nonsyndromic ocular 12.3
21 lattice degeneration of retina leading to retinal detachment 12.2
22 diverticulosis of bowel, hernia, and retinal detachment 12.2
23 knobloch syndrome 1 12.1
24 knobloch syndrome 12.1
25 vitreoretinopathy, neovascular inflammatory 11.6
26 retinoschisis 1, x-linked, juvenile 11.6
27 stickler syndrome, type i 11.6
28 stickler syndrome 11.4
29 pars planitis 11.4
30 isolated ectopia lentis 11.4
31 kniest dysplasia 11.4
32 spondyloepiphyseal dysplasia congenita 11.4
33 spondyloepimetaphyseal dysplasia, strudwick type 11.4
34 retinochoroidal coloboma 11.4
35 wagner syndrome 11.4
36 papillorenal syndrome 11.2
37 wagner vitreoretinopathy 11.2
38 ectopia lentis et pupillae 11.2
39 exudative vitreoretinopathy 2, x-linked 11.2
40 exudative vitreoretinopathy 4 11.2
41 stickler syndrome, type ii 11.2
42 coloboma of optic nerve 11.0
43 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 11.0
44 vitreoretinochoroidopathy 11.0
45 vitreoretinal degeneration, snowflake type 11.0
46 exudative vitreoretinopathy 3 11.0
47 spondyloocular syndrome 11.0
48 lethal congenital contracture syndrome 2 11.0
49 cavitary optic disc anomalies 11.0
50 exudative vitreoretinopathy 5 11.0

Comorbidity relations with Retinal Detachment via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to Retinal Detachment

Symptoms & Phenotypes for Retinal Detachment

Symptoms via clinical synopsis from OMIM:

57
Eyes:
retinal detachment
no myopia


Clinical features from OMIM:

180050

Human phenotypes related to Retinal Detachment:

32
# Description HPO Frequency HPO Source Accession
1 retinal detachment 32 HP:0000541

MGI Mouse Phenotypes related to Retinal Detachment:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4 GFAP
2 behavior/neurological MP:0005386 10.26 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4 GFAP
3 nervous system MP:0003631 10.2 ATOH7 COL11A1 COL18A1 COL2A1 CTNNB1 FZD4
4 cellular MP:0005384 10.19 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4 GFAP
5 growth/size/body region MP:0005378 10.17 CAPN5 COL11A1 COL2A1 CTNNB1 FZD4 GFAP
6 immune system MP:0005387 10.07 CAPN5 COL11A1 COL2A1 CTNNB1 GFAP LRP5
7 digestive/alimentary MP:0005381 10.06 COL11A1 COL2A1 CTNNB1 FZD4 GFAP KCNJ13
8 craniofacial MP:0005382 10.02 COL11A1 COL18A1 COL2A1 CTNNB1 KCNJ13 LRP5
9 hearing/vestibular/ear MP:0005377 9.88 COL11A1 COL2A1 CTNNB1 FZD4 NDP TSPAN12
10 normal MP:0002873 9.86 ATOH7 COL2A1 CTNNB1 FZD4 GFAP GLUL
11 pigmentation MP:0001186 9.85 ADAMTSL4 COL18A1 CTNNB1 FZD4 LRP5 NDP
12 skeleton MP:0005390 9.61 COL11A1 COL18A1 COL2A1 CTNNB1 KCNJ13 LRP5
13 vision/eye MP:0005391 9.5 ADAMTSL4 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4

Drugs & Therapeutics for Retinal Detachment

Drugs for Retinal Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
2
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 1 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 1 2921-57-5
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
7
Prednisolone Approved, Vet_approved Phase 4,Phase 1 50-24-8 5755
8
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 347396-82-1 459903
9
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
10
Verteporfin Approved, Investigational Phase 4,Phase 2,Not Applicable 129497-78-5
11
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
12
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
13
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
14
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
17
Rasagiline Approved Phase 4 136236-51-6 3052776
18
Prednisolone hemisuccinate Experimental Phase 4,Phase 1 2920-86-7
19 Diuretics, Potassium Sparing Phase 4
20 Anesthetics, Local Phase 4,Not Applicable
21 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Sodium Channel Blockers Phase 4
25 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
26 Analgesics Phase 4,Phase 3,Not Applicable
27 Analgesics, Non-Narcotic Phase 4,Phase 3
28 Antirheumatic Agents Phase 4,Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
30 Ketorolac Tromethamine Phase 4
31 Cyclooxygenase Inhibitors Phase 4
32 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
33 Protective Agents Phase 4,Phase 2,Not Applicable
34 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
35 Methylprednisolone acetate Phase 4,Phase 1
36 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Not Applicable
40 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Not Applicable
41 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
43 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Not Applicable
44 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
45 Prednisolone acetate Phase 4,Phase 1
46 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
47 Neuroprotective Agents Phase 4,Phase 2
48 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 256)
# Name Status NCT ID Phase Drugs
1 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
2 Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity Unknown status NCT00634972 Phase 4 ACULAR;REFRESH TEARS;placebo
3 IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids Unknown status NCT00744666 Phase 4 Prednisolone 1% topical eye drops
4 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4 Aflibercept Injection
5 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) Unknown status NCT01670162 Phase 4 Aflibercept
6 Effects of Ranibizumab to Delay or Regression Non-proliferative Diabetic Retinopathy(NPDR) With DME Assessed by Microaneurysm Changes: A Pilot Study Unknown status NCT02834663 Phase 4 Lucentis
7 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
8 To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema Unknown status NCT02462304 Phase 4 ranibizumab;Bevacizumab
9 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery Completed NCT01001429 Phase 4 Dexmedetomidine infusion;propofol
10 Isotretinoin for Proliferative Vitreoretinopathy Completed NCT01445028 Phase 4 Isotretinoin
11 Postoperative Pain Control Following Vitreoretinal Surgery Completed NCT01995045 Phase 4 Triamcinolone;Bupivicaine Hydrochloride
12 Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab
13 Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery Completed NCT02729285 Phase 4 Ketorolac Tromethamine;placebo
14 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA Completed NCT03246152 Phase 4 Bevacizumab
15 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
16 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
17 Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification Completed NCT03321253 Phase 4
18 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
19 Intravitreal Ranibizumab in Retinal Pigment Epithelial Detachments Completed NCT00976222 Phase 4 intravitreal injection with ranibizumab
20 Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD) Completed NCT02142296 Phase 4 Eylea
21 Study to Investigate the Safety and Efficacy of Ranibizumab in Patients With Choroidal Neovascularisation Due to Causes Other Than Age Related Macular Degeneration Completed NCT01628354 Phase 4 Ranibizumab
22 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
23 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
24 Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment Active, not recruiting NCT02068625 Phase 4 Rasagiline;Placebo
25 TTT Versus TTT and Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy Active, not recruiting NCT02379000 Phase 4 Triamcinolone Acetonide
26 Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery Withdrawn NCT01326585 Phase 4 Dexamethasone Sodium Phosphate Injection;Saline Injection
27 Open Label to Study to Evaluate Effect of Alfilbercept on Patients With (FVPED) Fibrovascular Pigment Epithelial Detachment Withdrawn NCT01495208 Phase 4 Aflibercept
28 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Withdrawn NCT01666236 Phase 4
29 Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment. Unknown status NCT02834559 Phase 3 5-fluorouracil and low molecular weight heparin;Placebo
30 Pressurized PPV 23GA Vitrectomy in Complicated Diabetic Tractional Retinal Detachment Unknown status NCT00404209 Phase 3
31 Comparison High-Density Silicone Oils in Retinal Detachment Unknown status NCT00403702 Phase 2, Phase 3 Oxane HD [oil-RMN3-mixture];Densiron [(F6H8)
32 Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment Unknown status NCT00370201 Phase 3 colchicine
33 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
34 Evaluation of Ranibizumab in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomy Unknown status NCT00516464 Phase 3 Lucentis (ranibizumab)
35 Perfluorocarbon Perfused Vitrectomy and 3D Vitrectomy System in Advanced Diabetic Retinopathy Unknown status NCT00407108 Phase 3
36 25-Gauge Vitrectomy With Ranibizumab or Triamcinolone Acetonide on Proliferative Diabetic Retinopathy in China Unknown status NCT02328118 Phase 2, Phase 3 Ranibizumab;Triamcinolone Acetonide
37 Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR) Unknown status NCT00370721 Phase 3 bevacizumab
38 Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy Completed NCT01976923 Phase 3 Intravitreal bevacizumab
39 Comparison of Air and Expansile Gas in Pneumatic Retinopexy Completed NCT00120445 Phase 3
40 Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation Completed NCT01068379 Phase 3
41 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
42 Diabetic Retinopathy Vitrectomy Study (DRVS) Completed NCT00000154 Phase 3
43 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis Completed NCT01768078 Phase 3
44 Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity Completed NCT01079715 Phase 2, Phase 3 Propranolol
45 Comparison of AC and PC Lenses After Vitreous Loss During ECCE Completed NCT00453011 Phase 3
46 Bevacizumab and Long Acting Gas in Diabetic Vitrectomy Completed NCT00656435 Phase 3 Bevacizumab
47 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3 bevacizumab;Ranibizumab
48 Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial. Completed NCT00781859 Phase 3 125 µg Ocriplasmin;Placebo
49 Green Laser Photocoagulation Study in Proliferative Diabetic Retinopathy Completed NCT00355680 Phase 3
50 Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy Completed NCT00373282 Phase 3 Triamcinolone acetonide

Search NIH Clinical Center for Retinal Detachment

Cochrane evidence based reviews: retinal detachment

Genetic Tests for Retinal Detachment

Genetic tests related to Retinal Detachment:

# Genetic test Affiliating Genes
1 Retinal Detachment 29

Anatomical Context for Retinal Detachment

MalaCards organs/tissues related to Retinal Detachment:

41
Eye, Retina, Brain, Endothelial, Bone, Liver, Kidney

Publications for Retinal Detachment

Articles related to Retinal Detachment:

(show top 50) (show all 2207)
# Title Authors Year
1
ILM peeling in macular hole retinal detachment: insert or not? ( 29909575 )
2018
2
Accuracy of axial length measurements obtained by optical biometry and acoustic biometry in rhegmatogenous retinal detachment: a prospective study. ( 29872256 )
2018
3
Clinicopathologic Correlation of a Subretinal Proliferative Vitreoretinopathy Band in a Patient with Chronic Recurrent Retinal Detachment. ( 29928223 )
2018
4
Retinal detachment after acute posterior vitreous detachment resulting from posterior chamber phakic intraocular lens implantation. ( 29502596 )
2018
5
Nonaccidental injury presenting as unilateral Retinal Detachment in two infants. ( 29410140 )
2018
6
Inverted internal limiting membrane insertion versus standard internal limiting membrane peeling for macular hole retinal detachment in high myopia: one-year study. ( 29911271 )
2018
7
Acute retinal detachment induced by the Valsalva manoeuvre in morning glory disc anomaly. ( 29374647 )
2018
8
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment?: A response. ( 29793773 )
2018
9
Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study. ( 29359109 )
2018
10
Retinal detachment in albinism. ( 29670325 )
2018
11
Bilateral Asymmetric Rhegmatogenous Retinal Detachment in a Patient with Stickler Syndrome. ( 29755825 )
2018
12
25-gauge vitrectomy and gas for the management of rhegmatogenous retinal detachment. ( 29967564 )
2018
13
Segmental Analysis of Macular Layers in Patients With Rhegmatogenous Retinal Detachment Treated With Perfluoropropane or Silicon Oil. ( 29304265 )
2018
14
Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. ( 29877085 )
2018
15
Bone inside eye: choroidal osteoma presenting as exudative retinal detachment: a challenge to diagnosis. ( 29914906 )
2018
16
Myelin Oligodendrocyte Glycoprotein-IgG-positive Recurrent Bilateral Optic Papillitis with Serous Retinal Detachment: A Case Report. ( 29780155 )
2018
17
Central Scotoma after Removal of Silicone Oil in Retinal Detachment: A Multimodal Imaging Case Report. ( 29490394 )
2018
18
RECURRENT OPENING AND CLOSURE OF MACULAR HOLE AFTER PARS PLANA VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT. ( 29315126 )
2018
19
Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. ( 29915052 )
2018
20
IMPACT OF INNER LIMITING MEMBRANE PEELING ON VISUAL RECOVERY AFTER VITRECTOMY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT INVOLVING THE FOVEA. ( 29394235 )
2018
21
ASSOCIATION STUDY BETWEEN POLYMORPHISMS OF THE p53 AND LYMPHOTOXIN ALPHA (LTA) GENES AND THE RISK OF PROLIFERATIVE VITREORETINOPATHY/RETINAL DETACHMENT IN A MEXICAN POPULATION. ( 28106707 )
2018
22
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment. ( 29389404 )
2018
23
Perfluorocarbon Liquid Vs. Subretinal Fluid Drainage during Vitrectomy for the Primary Repair of Rhegmatogenous Retinal Detachment: A Comparative Study. ( 29912572 )
2018
24
Association of Macular and Peripheral Retinal Macro-Pseudocysts With Chronic Retinal Detachment. ( 29902288 )
2018
25
Photodynamic therapy for bullous retinal detachment: a single-center experience of case series with a 6-month follow-up study. ( 29869216 )
2018
26
Bilateral total retinal detachment at birth: a case report of Walker-Warburg syndrome. ( 29386918 )
2018
27
Multiple Free Internal Limiting Membrane Flap Insertion in the Treatment of Macular Hole-Associated Retinal Detachment in High Myopia. ( 29874671 )
2018
28
VALIDITY AND EFFICACY OF INTERNAL LIMITING MEMBRANE PEELING DURING INITIAL VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT: VISUAL OUTCOMES IN MACULA-SPARING CASES. ( 29944610 )
2018
29
Final anatomic and visual outcomes appear independent of duration of silicone oil intraocular tamponade in complex retinal detachment surgery. ( 29375996 )
2018
30
Sandwich technique using a combination of perfluoropropane and silicone oil for inferior retinal detachment. ( 29941745 )
2018
31
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29784278 )
2018
32
Intraocular currents, Bernoulli's principle and non-drainage scleral buckling for rhegmatogenous retinal detachment. ( 29350687 )
2018
33
Modified transscleral external drainage of subretinal fluid in high bullous exudative retinal detachment due to Coats' disease. ( 29930459 )
2018
34
Risk Factors for Development of Rhegmatogenous Retinal Detachment in Patients with Uveitis. ( 29420113 )
2018
35
The use of ocular ultrasound to diagnose retinal detachment: a case demonstrating the sonographic findings. ( 29404803 )
2018
36
Surgical outcomes of preoperative steroid for rhegmatogenous retinal detachment with associated choroidal detachment. ( 29219956 )
2018
37
Development of Surgical Management in Primary Rhegmatogenous Retinal Detachment Treatment from 2009 to 2015. ( 29364728 )
2018
38
Foveal Avascular Zone Area Changes Analyzed Using OCT Angiography after Successful Rhegmatogenous Retinal Detachment Repair. ( 29451996 )
2018
39
Jules Gonin and the Nobel Prize: pioneer of retinal detachment surgery who almost received a Nobel Prize in medicine. ( 29372074 )
2018
40
Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review. ( 29969330 )
2018
41
Case Report of a Family Affected by Stickler Syndrome in Which Rhegmatogenous Retinal Detachment Occurred in Five Eyes of Three Siblings. ( 29643775 )
2018
42
Evaluation of the treatment results in patients with rhegmatogenous retinal detachment treated by pars plana vitrectomy with air: Preliminary results. ( 29851816 )
2018
43
Bilateral rhegmatogenous retinal detachment due to unusual retinal degeneration in Down syndrome: A case report. ( 29851814 )
2018
44
Frequency of pediatric traumatic cataract and simultaneous retinal detachment. ( 30366052 )
2018
45
Rhegmatogenous Retinal Detachment after Pediatric Cataract Surgery. ( 29268866 )
2018
46
Coats disease with exudative retinal detachment simulating cysticercus cyst: misleading ultrasonography! ( 29321199 )
2018
47
CONGENITAL TOXOPLASMOSIS ASSOCIATED WITH TRACTIONAL RETINAL DETACHMENT. ( 30015769 )
2018
48
Effectiveness of Intravitreal Ranibizumab for Diabetic Macular Edema with Serous Retinal Detachment. ( 30091308 )
2018
49
A Novel Biomarker in Diabetic Macular Edema with Serous Retinal Detachment: Serum Chitinase-3-Like Protein 1. ( 30130755 )
2018
50
Comparison of the effect of ranibizumab and dexamethasone implant on serous retinal detachment in diabetic macular edema. ( 30213609 )
2018

Variations for Retinal Detachment

ClinVar genetic disease variations for Retinal Detachment:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RHO NM_000539.3(RHO): c.891C> G (p.Ser297Arg) single nucleotide variant Pathogenic rs142285818 GRCh37 Chromosome 3, 129251570: 129251570
2 RHO NM_000539.3(RHO): c.891C> G (p.Ser297Arg) single nucleotide variant Pathogenic rs142285818 GRCh38 Chromosome 3, 129532727: 129532727
3 EYS NM_001142800.1(EYS): c.4152delT (p.Pro1385Leufs) deletion Uncertain significance GRCh37 Chromosome 6, 65301608: 65301608
4 EYS NM_001142800.1(EYS): c.4152delT (p.Pro1385Leufs) deletion Uncertain significance GRCh38 Chromosome 6, 64591715: 64591715
5 NDP NM_000266.3(NDP): c.308_311dup (p.Lys104Asnfs) duplication Likely pathogenic GRCh38 Chromosome X, 43949890: 43949893
6 NDP NM_000266.3(NDP): c.308_311dup (p.Lys104Asnfs) duplication Likely pathogenic GRCh37 Chromosome X, 43809136: 43809139

Expression for Retinal Detachment

Search GEO for disease gene expression data for Retinal Detachment.

Pathways for Retinal Detachment

GO Terms for Retinal Detachment

Cellular components related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 COL11A1 COL18A1 COL2A1 NDP PDGFB RS1
2 extracellular region GO:0005576 9.91 ADAMTSL4 COL11A1 COL18A1 COL2A1 NDP PDGFB
3 cell surface GO:0009986 9.88 CAPN5 FZD4 NDP PDGFB VEGFA
4 basement membrane GO:0005604 9.63 COL18A1 COL2A1 SERPINF1
5 collagen trimer GO:0005581 9.61 COL11A1 COL18A1 COL2A1
6 extracellular matrix GO:0031012 9.55 ADAMTSL4 COL11A1 COL18A1 COL2A1 VEGFA
7 glial cell projection GO:0097386 9.4 GFAP GLUL
8 Wnt signalosome GO:1990909 9.37 CTNNB1 LRP5
9 endoplasmic reticulum lumen GO:0005788 9.35 ADAMTSL4 COL11A1 COL18A1 COL2A1 PDGFB
10 collagen-containing extracellular matrix GO:0062023 9.1 COL11A1 COL18A1 COL2A1 NDP PDGFB SERPINF1

Biological processes related to Retinal Detachment according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 CTNNB1 FZD4 LRP5 NDP PDGFB
2 positive regulation of cell proliferation GO:0008284 9.95 COL18A1 CTNNB1 LRP5 PDGFB VEGFA
3 negative regulation of gene expression GO:0010629 9.84 CTNNB1 PDGFB SERPINF1 VEGFA
4 kidney development GO:0001822 9.75 CTNNB1 SERPINF1 VEGFA
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 CTNNB1 FZD4 NDP
6 sensory perception of sound GO:0007605 9.71 COL11A1 COL2A1 FZD4 NDP
7 vasculogenesis GO:0001570 9.69 CTNNB1 FZD4 VEGFA
8 Wnt signaling pathway GO:0016055 9.65 CTNNB1 FZD4 LRP5 NDP TSPAN12
9 heart morphogenesis GO:0003007 9.61 COL11A1 COL2A1 VEGFA
10 cartilage condensation GO:0001502 9.59 COL11A1 COL2A1
11 gastrulation with mouth forming second GO:0001702 9.58 CTNNB1 LRP5
12 proteoglycan metabolic process GO:0006029 9.52 COL11A1 COL2A1
13 positive regulation of mesenchymal cell proliferation GO:0002053 9.5 CTNNB1 LRP5 VEGFA
14 retina vasculature morphogenesis in camera-type eye GO:0061299 9.48 FZD4 NDP
15 retinal blood vessel morphogenesis GO:0061304 9.46 FZD4 LRP5
16 canonical Wnt signaling pathway GO:0060070 9.46 CTNNB1 FZD4 LRP5 NDP
17 extracellular matrix organization GO:0030198 9.43 ADAMTSL4 COL11A1 COL18A1 COL2A1 GFAP PDGFB
18 extracellular matrix-cell signaling GO:0035426 9.37 FZD4 NDP
19 visual perception GO:0007601 9.1 COL11A1 COL18A1 COL2A1 NDP RHO RS1
20 multicellular organism development GO:0007275 10.04 ATOH7 FZD4 LRP5 PDGFB RS1 SERPINF1

Molecular functions related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.5 COL11A1 COL18A1 COL2A1
2 platelet-derived growth factor receptor binding GO:0005161 9.26 PDGFB VEGFA
3 platelet-derived growth factor binding GO:0048407 9.16 COL2A1 PDGFB
4 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL11A1 COL18A1 COL2A1
5 Wnt-activated receptor activity GO:0042813 8.8 FZD4 LRP5 TSPAN12

Sources for Retinal Detachment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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