Aliases & Classifications for Retinal Detachment

MalaCards integrated aliases for Retinal Detachment:

Name: Retinal Detachment 57 12 29 55 6 43 44 15 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
retinal detachment:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 180050
Disease Ontology 12 DOID:5327
ICD10 33 H33.2 H33.0
ICD9CM 35 361.9
MeSH 44 D012163
NCIt 50 C26874
MedGen 42 C0035305
SNOMED-CT via HPO 69 263681008
UMLS 73 C0035305

Summaries for Retinal Detachment

MedlinePlus : 43 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. It provides the sharp, central vision needed for reading, driving, and seeing fine detail. A retinal detachment lifts or pulls the retina from its normal position. It can occur at any age, but it is more common in people over age 40. It affects men more than women and whites more than African Americans. A retinal detachment is also more likely to occur in people who Are extremely nearsighted Have had a retinal detachment in the other eye Have a family history of retinal detachment Have had cataract surgery Have other eye diseases or disorders Have had an eye injury Symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. It may also seem like there is a "curtain" over your field of vision. A retinal detachment is a medical emergency. If not promptly treated, it can cause permanent vision loss. If you have any symptoms, see an eye care professional immediately. Treatment includes different types of surgery. NIH: National Eye Institute

MalaCards based summary : Retinal Detachment is related to persistent hyperplastic primary vitreous, autosomal recessive and persistent hyperplastic primary vitreous. An important gene associated with Retinal Detachment is RHO (Rhodopsin), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. The drugs Lidocaine and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are retinal detachment and cardiovascular system

OMIM : 57 Primary or spontaneous detachment of the retina occurs due to underlying ocular disease and often involves the vitreous as well as the retina. The precipitating event is formation of a retinal tear or hole, which permits fluid to accumulate under the sensory layers of the retina and creates an intraretinal cleavage that destroys the neurosensory process of visual reception. Vitreoretinal degeneration and tear formation are painless phenomena, and in most cases, significant vitreoretinal pathology is found only after detachment of the retina starts to cause loss of vision or visual field. Without surgical intervention, retinal detachment will almost inevitably lead to total blindness (summary by McNiel and McPherson, 1971). (180050)

Wikipedia : 76 Retinal detachment is a disorder of the eye in which the retina separates from the layer underneath.... more...

Related Diseases for Retinal Detachment

Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous, autosomal recessive 33.6 ATOH7 TSPAN12
2 persistent hyperplastic primary vitreous 32.2 ATOH7 FZD4 NDP TSPAN12
3 retinal disease 31.8 NDP RHO RS1
4 exudative vitreoretinopathy 31.2 ATOH7 CTNNB1 FZD4 LRP5 NDP TSPAN12
5 exudative vitreoretinopathy 1 31.2 CTNNB1 FZD4 LRP5 NDP TSPAN12 VEGFA
6 retinal perforation 30.9 COL11A1 COL2A1 KCNJ13
7 myopia 30.8 COL11A1 COL18A1 COL2A1 RHO VEGFA
8 strabismus 30.5 COL11A1 COL2A1 CTNNB1 RS1
9 macular dystrophy, dominant cystoid 30.5 CAPN5 VEGFA
10 coats disease 30.3 FZD4 LRP5 NDP RHO RS1 TSPAN12
11 macular retinal edema 30.0 CAPN5 SERPINF1 VEGFA
12 osteoporosis-pseudoglioma syndrome 30.0 CTNNB1 FZD4 LRP5 NDP
13 vitreoretinal degeneration 30.0 COL11A1 COL18A1 COL2A1 KCNJ13
14 norrie disease 29.9 FZD4 LRP5 NDP TSPAN12
15 retinal telangiectasia 29.6 FZD4 NDP TSPAN12 VEGFA
16 macular degeneration, age-related, 1 28.2 COL18A1 RHO SERPINF1 VEGFA
17 retinitis pigmentosa 26.6 CAPN5 COL18A1 GFAP RHO RS1 SERPINF1
18 stickler syndrome, type i, nonsyndromic ocular 12.1
19 lattice degeneration of retina leading to retinal detachment 12.0
20 diverticulosis of bowel, hernia, and retinal detachment 12.0
21 knobloch syndrome 1 12.0
22 knobloch syndrome 11.9
23 vitreoretinopathy, neovascular inflammatory 11.5
24 stickler syndrome 11.3
25 morning glory syndrome 11.2
26 retinitis 11.2
27 pars planitis 11.2
28 kniest dysplasia 11.2
29 spondyloepiphyseal dysplasia congenita 11.2
30 spondyloepimetaphyseal dysplasia, strudwick type 11.2
31 isolated ectopia lentis 11.2
32 juvenile retinoschisis 11.2
33 retinochoroidal coloboma 11.2
34 wagner syndrome 11.2
35 stickler syndrome, type i 11.1
36 papillorenal syndrome 11.0
37 ectopia lentis et pupillae 11.0
38 exudative vitreoretinopathy 2, x-linked 11.0
39 retinoschisis 1, x-linked, juvenile 11.0
40 exudative vitreoretinopathy 4 11.0
41 stickler syndrome, type ii 11.0
42 coloboma of optic nerve 10.9
43 wagner vitreoretinopathy 10.9
44 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 10.9
45 vitreoretinal degeneration, snowflake type 10.9
46 donnai-barrow syndrome 10.9
47 exudative vitreoretinopathy 3 10.9
48 spondyloocular syndrome 10.9
49 cavitary optic disc anomalies 10.9
50 exudative vitreoretinopathy 5 10.9

Comorbidity relations with Retinal Detachment via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to Retinal Detachment

Symptoms & Phenotypes for Retinal Detachment

Symptoms via clinical synopsis from OMIM:

57
Eyes:
retinal detachment
no myopia


Clinical features from OMIM:

180050

Human phenotypes related to Retinal Detachment:

32
# Description HPO Frequency HPO Source Accession
1 retinal detachment 32 HP:0000541

MGI Mouse Phenotypes related to Retinal Detachment:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 NDP PDGFB RHO SERPINF1 TSPAN12 VEGFA
2 behavior/neurological MP:0005386 10.26 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4 GFAP
3 nervous system MP:0003631 10.2 ATOH7 COL11A1 COL18A1 COL2A1 CTNNB1 FZD4
4 cellular MP:0005384 10.19 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4 GFAP
5 growth/size/body region MP:0005378 10.17 CAPN5 COL11A1 COL2A1 CTNNB1 FZD4 GFAP
6 immune system MP:0005387 10.07 CAPN5 COL11A1 COL2A1 CTNNB1 GFAP LRP5
7 digestive/alimentary MP:0005381 10.06 COL11A1 COL2A1 CTNNB1 FZD4 GFAP KCNJ13
8 craniofacial MP:0005382 10.02 COL11A1 COL18A1 COL2A1 CTNNB1 KCNJ13 LRP5
9 hearing/vestibular/ear MP:0005377 9.88 COL11A1 COL2A1 CTNNB1 FZD4 NDP TSPAN12
10 normal MP:0002873 9.86 CTNNB1 FZD4 GFAP GLUL LRP5 ATOH7
11 pigmentation MP:0001186 9.85 LRP5 NDP PDGFB RHO RS1 SERPINF1
12 skeleton MP:0005390 9.61 SERPINF1 VEGFA COL11A1 COL18A1 COL2A1 CTNNB1
13 vision/eye MP:0005391 9.5 ADAMTSL4 ATOH7 COL18A1 COL2A1 CTNNB1 FZD4

Drugs & Therapeutics for Retinal Detachment

Drugs for Retinal Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
2
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
6
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 347396-82-1 459903
7
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
8
Verteporfin Approved, Investigational Phase 4,Phase 2,Not Applicable 129497-78-5
9
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
10
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
11
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
12
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
14
Rasagiline Approved Phase 4 136236-51-6 3052776
15 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Anesthetics, Local Phase 4,Not Applicable
17 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Not Applicable
18 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
19 Diuretics, Potassium Sparing Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Sodium Channel Blockers Phase 4
22 Analgesics Phase 4,Phase 3,Not Applicable
23 Analgesics, Non-Narcotic Phase 4,Phase 3
24 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
26 Antirheumatic Agents Phase 4,Phase 3
27 Cyclooxygenase Inhibitors Phase 4
28 Ketorolac Tromethamine Phase 4
29 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
31 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
35 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Methylprednisolone acetate Phase 4
39 Methylprednisolone Hemisuccinate Phase 4
40 Neuroprotective Agents Phase 4,Phase 2
41 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Prednisolone acetate Phase 4
43 Prednisolone hemisuccinate Phase 4
44 Prednisolone phosphate Phase 4
45 Protective Agents Phase 4,Phase 2,Not Applicable
46 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Not Applicable
47 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Not Applicable
48 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Not Applicable
49 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Not Applicable
50 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 238)
# Name Status NCT ID Phase Drugs
1 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
2 Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity Unknown status NCT00634972 Phase 4 ACULAR;REFRESH TEARS;placebo
3 IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids Unknown status NCT00744666 Phase 4 Prednisolone 1% topical eye drops
4 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4 Aflibercept Injection
5 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) Unknown status NCT01670162 Phase 4 Aflibercept
6 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
7 To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema Unknown status NCT02462304 Phase 4 ranibizumab;Bevacizumab
8 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery Completed NCT01001429 Phase 4 Dexmedetomidine infusion;propofol
9 Isotretinoin for Proliferative Vitreoretinopathy Completed NCT01445028 Phase 4 Isotretinoin
10 Postoperative Pain Control Following Vitreoretinal Surgery Completed NCT01995045 Phase 4 Triamcinolone;Bupivicaine Hydrochloride
11 Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab
12 Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery Completed NCT02729285 Phase 4 Ketorolac Tromethamine;placebo
13 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
14 Open Label to Study to Evaluate Effect of Alfilbercept on Patients With (FVPED) Fibrovascular Pigment Epithelial Detachment Completed NCT01495208 Phase 4 Aflibercept
15 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
16 Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification Completed NCT03321253 Phase 4
17 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
18 Intravitreal Ranibizumab in Retinal Pigment Epithelial Detachments Completed NCT00976222 Phase 4 intravitreal injection with ranibizumab
19 Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD) Completed NCT02142296 Phase 4 Eylea
20 Study to Investigate the Safety and Efficacy of Ranibizumab in Patients With Choroidal Neovascularisation Due to Causes Other Than Age Related Macular Degeneration Completed NCT01628354 Phase 4 Ranibizumab
21 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
22 Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment Recruiting NCT02068625 Phase 4 Rasagiline;Placebo
23 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA Recruiting NCT03246152 Phase 4 Bevacizumab
24 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
25 TTT Versus TTT and Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy Active, not recruiting NCT02379000 Phase 4 Triamcinolone Acetonide
26 Effects of Ranibizumab to Delay or Regression Non-proliferative Diabetic Retinopathy(NPDR) With DME Assessed by Microaneurysm Changes: A Pilot Study Not yet recruiting NCT02834663 Phase 4 Lucentis
27 Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery Withdrawn NCT01326585 Phase 4 Dexamethasone Sodium Phosphate Injection;Saline Injection
28 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Withdrawn NCT01666236 Phase 4
29 Pressurized PPV 23GA Vitrectomy in Complicated Diabetic Tractional Retinal Detachment Unknown status NCT00404209 Phase 3
30 Comparison High-Density Silicone Oils in Retinal Detachment Unknown status NCT00403702 Phase 2, Phase 3 Oxane HD [oil-RMN3-mixture];Densiron [(F6H8)
31 Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment Unknown status NCT00370201 Phase 3 colchicine
32 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
33 Evaluation of Ranibizumab in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomy Unknown status NCT00516464 Phase 3 Lucentis (ranibizumab)
34 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis Unknown status NCT01768078 Phase 3
35 Perfluorocarbon Perfused Vitrectomy and 3D Vitrectomy System in Advanced Diabetic Retinopathy Unknown status NCT00407108 Phase 3
36 Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR) Unknown status NCT00370721 Phase 3 bevacizumab
37 Comparison of Air and Expansile Gas in Pneumatic Retinopexy Completed NCT00120445 Phase 3
38 Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation Completed NCT01068379 Phase 3
39 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
40 Diabetic Retinopathy Vitrectomy Study (DRVS) Completed NCT00000154 Phase 3
41 Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity Completed NCT01079715 Phase 2, Phase 3 Propranolol
42 Comparison of AC and PC Lenses After Vitreous Loss During ECCE Completed NCT00453011 Phase 3
43 Bevacizumab and Long Acting Gas in Diabetic Vitrectomy Completed NCT00656435 Phase 3 Bevacizumab
44 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3 bevacizumab;Ranibizumab
45 Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial. Completed NCT00781859 Phase 3 125 µg Ocriplasmin;Placebo
46 Green Laser Photocoagulation Study in Proliferative Diabetic Retinopathy Completed NCT00355680 Phase 3
47 Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy Completed NCT00373282 Phase 3 Triamcinolone acetonide
48 A Single Centre Study to Compare the Efficacy and Safety of Femtosecond Laser-Assisted Versus Manual Cataract Surgery Completed NCT01373853 Phase 3
49 Lucentis for Age-related Macular Degeneration Pigment Epithelial Detachments Completed NCT00590694 Phase 2, Phase 3 ranibizumab
50 Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Completed NCT01941329 Phase 2, Phase 3 Intravitreous injection of ranibizumab

Search NIH Clinical Center for Retinal Detachment

Cochrane evidence based reviews: retinal detachment

Genetic Tests for Retinal Detachment

Genetic tests related to Retinal Detachment:

# Genetic test Affiliating Genes
1 Retinal Detachment 29

Anatomical Context for Retinal Detachment

MalaCards organs/tissues related to Retinal Detachment:

41
Eye, Retina, Brain, Endothelial, Liver, Lung, Testes

Publications for Retinal Detachment

Articles related to Retinal Detachment:

(show top 50) (show all 1509)
# Title Authors Year
1
ILM peeling in macular hole retinal detachment: insert or not? ( 29909575 )
2018
2
Accuracy of axial length measurements obtained by optical biometry and acoustic biometry in rhegmatogenous retinal detachment: a prospective study. ( 29872256 )
2018
3
Clinicopathologic Correlation of a Subretinal Proliferative Vitreoretinopathy Band in a Patient with Chronic Recurrent Retinal Detachment. ( 29928223 )
2018
4
Retinal detachment after acute posterior vitreous detachment resulting from posterior chamber phakic intraocular lens implantation. ( 29502596 )
2018
5
Nonaccidental injury presenting as unilateral Retinal Detachment in two infants. ( 29410140 )
2018
6
Inverted internal limiting membrane insertion versus standard internal limiting membrane peeling for macular hole retinal detachment in high myopia: one-year study. ( 29911271 )
2018
7
Acute retinal detachment induced by the Valsalva manoeuvre in morning glory disc anomaly. ( 29374647 )
2018
8
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment?: A response. ( 29793773 )
2018
9
Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study. ( 29359109 )
2018
10
Retinal detachment in albinism. ( 29670325 )
2018
11
Bilateral Asymmetric Rhegmatogenous Retinal Detachment in a Patient with Stickler Syndrome. ( 29755825 )
2018
12
25-gauge vitrectomy and gas for the management of rhegmatogenous retinal detachment. ( 29967564 )
2018
13
Segmental Analysis of Macular Layers in Patients With Rhegmatogenous Retinal Detachment Treated With Perfluoropropane or Silicon Oil. ( 29304265 )
2018
14
Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. ( 29877085 )
2018
15
Bone inside eye: choroidal osteoma presenting as exudative retinal detachment: a challenge to diagnosis. ( 29914906 )
2018
16
Myelin Oligodendrocyte Glycoprotein-IgG-positive Recurrent Bilateral Optic Papillitis with Serous Retinal Detachment: A Case Report. ( 29780155 )
2018
17
Central Scotoma after Removal of Silicone Oil in Retinal Detachment: A Multimodal Imaging Case Report. ( 29490394 )
2018
18
RECURRENT OPENING AND CLOSURE OF MACULAR HOLE AFTER PARS PLANA VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT. ( 29315126 )
2018
19
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
20
Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. ( 29915052 )
2018
21
IMPACT OF INNER LIMITING MEMBRANE PEELING ON VISUAL RECOVERY AFTER VITRECTOMY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT INVOLVING THE FOVEA. ( 29394235 )
2018
22
ASSOCIATION STUDY BETWEEN POLYMORPHISMS OF THE p53 AND LYMPHOTOXIN ALPHA (LTA) GENES AND THE RISK OF PROLIFERATIVE VITREORETINOPATHY/RETINAL DETACHMENT IN A MEXICAN POPULATION. ( 28106707 )
2018
23
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment. ( 29389404 )
2018
24
Perfluorocarbon Liquid Vs. Subretinal Fluid Drainage during Vitrectomy for the Primary Repair of Rhegmatogenous Retinal Detachment: A Comparative Study. ( 29912572 )
2018
25
Association of Macular and Peripheral Retinal Macro-Pseudocysts With Chronic Retinal Detachment. ( 29902288 )
2018
26
Photodynamic therapy for bullous retinal detachment: a single-center experience of case series with a 6-month follow-up study. ( 29869216 )
2018
27
Bilateral total retinal detachment at birth: a case report of Walker-Warburg syndrome. ( 29386918 )
2018
28
Multiple Free Internal Limiting Membrane Flap Insertion in the Treatment of Macular Hole-Associated Retinal Detachment in High Myopia. ( 29874671 )
2018
29
VALIDITY AND EFFICACY OF INTERNAL LIMITING MEMBRANE PEELING DURING INITIAL VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT: VISUAL OUTCOMES IN MACULA-SPARING CASES. ( 29944610 )
2018
30
Final anatomic and visual outcomes appear independent of duration of silicone oil intraocular tamponade in complex retinal detachment surgery. ( 29375996 )
2018
31
Sandwich technique using a combination of perfluoropropane and silicone oil for inferior retinal detachment. ( 29941745 )
2018
32
Long-Term Outcomes of Total Exudative Retinal Detachments in Stage 3B Coats Disease. ( 29361355 )
2018
33
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29784278 )
2018
34
Intraocular currents, Bernoulli's principle and non-drainage scleral buckling for rhegmatogenous retinal detachment. ( 29350687 )
2018
35
Modified transscleral external drainage of subretinal fluid in high bullous exudative retinal detachment due to Coats' disease. ( 29930459 )
2018
36
Risk Factors for Development of Rhegmatogenous Retinal Detachment in Patients with Uveitis. ( 29420113 )
2018
37
The use of ocular ultrasound to diagnose retinal detachment: a case demonstrating the sonographic findings. ( 29404803 )
2018
38
Surgical outcomes of preoperative steroid for rhegmatogenous retinal detachment with associated choroidal detachment. ( 29219956 )
2018
39
Development of Surgical Management in Primary Rhegmatogenous Retinal Detachment Treatment from 2009 to 2015. ( 29364728 )
2018
40
Foveal Avascular Zone Area Changes Analyzed Using OCT Angiography after Successful Rhegmatogenous Retinal Detachment Repair. ( 29451996 )
2018
41
Jules Gonin and the Nobel Prize: pioneer of retinal detachment surgery who almost received a Nobel Prize in medicine. ( 29372074 )
2018
42
Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review. ( 29969330 )
2018
43
Case Report of a Family Affected by Stickler Syndrome in Which Rhegmatogenous Retinal Detachment Occurred in Five Eyes of Three Siblings. ( 29643775 )
2018
44
Evaluation of the treatment results in patients with rhegmatogenous retinal detachment treated by pars plana vitrectomy with air: Preliminary results. ( 29851816 )
2018
45
Bilateral rhegmatogenous retinal detachment due to unusual retinal degeneration in Down syndrome: A case report. ( 29851814 )
2018
46
Impact of Metamorphopsia on Quality of Life after Successful Retinal Detachment Surgery. ( 29843151 )
2018
47
Coats disease with exudative retinal detachment simulating cysticercus cyst: misleading ultrasonography! ( 29321199 )
2018
48
Premacular membrane formation after scleral buckling for primary rhegmatogenous retinal detachment: prospective study and pathophysiological insights. ( 29945896 )
2018
49
Clinical outcomes of endoscope-assisted vitrectomy for treatment of rhegmatogenous retinal detachment. ( 29180845 )
2017
50
RETINAL DETACHMENT ASSOCIATED WITH PERIPAPILLARY STAPHYLOMA IMAGED WITH SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. ( 28072615 )
2017

Variations for Retinal Detachment

ClinVar genetic disease variations for Retinal Detachment:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RHO NM_000539.3(RHO): c.891C> G (p.Ser297Arg) single nucleotide variant Pathogenic rs142285818 GRCh37 Chromosome 3, 129251570: 129251570
2 RHO NM_000539.3(RHO): c.891C> G (p.Ser297Arg) single nucleotide variant Pathogenic rs142285818 GRCh38 Chromosome 3, 129532727: 129532727
3 EYS NM_001142800.1(EYS): c.4152delT (p.Pro1385Leufs) deletion Uncertain significance GRCh37 Chromosome 6, 65301608: 65301608
4 EYS NM_001142800.1(EYS): c.4152delT (p.Pro1385Leufs) deletion Uncertain significance GRCh38 Chromosome 6, 64591715: 64591715
5 NDP NM_000266.3(NDP): c.308_311dup (p.Lys104Asnfs) duplication Likely pathogenic GRCh38 Chromosome X, 43949890: 43949893
6 NDP NM_000266.3(NDP): c.308_311dup (p.Lys104Asnfs) duplication Likely pathogenic GRCh37 Chromosome X, 43809136: 43809139

Expression for Retinal Detachment

Search GEO for disease gene expression data for Retinal Detachment.

Pathways for Retinal Detachment

GO Terms for Retinal Detachment

Cellular components related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ADAMTSL4 COL11A1 COL18A1 COL2A1 NDP PDGFB
2 cell surface GO:0009986 9.85 CAPN5 FZD4 NDP PDGFB VEGFA
3 extracellular space GO:0005615 9.81 ADAMTSL4 COL11A1 COL18A1 COL2A1 NDP PDGFB
4 collagen trimer GO:0005581 9.61 COL11A1 COL18A1 COL2A1
5 basement membrane GO:0005604 9.58 COL18A1 COL2A1 SERPINF1
6 Wnt signalosome GO:1990909 9.37 CTNNB1 LRP5
7 endoplasmic reticulum lumen GO:0005788 9.35 ADAMTSL4 COL11A1 COL18A1 COL2A1 PDGFB
8 glial cell projection GO:0097386 9.26 GFAP GLUL
9 extracellular matrix GO:0031012 9.1 COL11A1 COL18A1 COL2A1 NDP PDGFB SERPINF1

Biological processes related to Retinal Detachment according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.98 CTNNB1 FZD4 LRP5 NDP PDGFB
2 positive regulation of cell proliferation GO:0008284 9.97 COL18A1 CTNNB1 LRP5 PDGFB VEGFA
3 negative regulation of gene expression GO:0010629 9.86 CTNNB1 PDGFB SERPINF1 VEGFA
4 Wnt signaling pathway GO:0016055 9.84 CTNNB1 FZD4 LRP5 NDP
5 kidney development GO:0001822 9.75 CTNNB1 SERPINF1 VEGFA
6 sensory perception of sound GO:0007605 9.73 COL11A1 COL2A1 FZD4 NDP
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 CTNNB1 FZD4 LRP5 NDP
8 collagen catabolic process GO:0030574 9.69 COL11A1 COL18A1 COL2A1
9 vasculogenesis GO:0001570 9.67 CTNNB1 FZD4 VEGFA
10 heart morphogenesis GO:0003007 9.65 COL11A1 COL2A1 VEGFA
11 extracellular matrix organization GO:0030198 9.63 ADAMTSL4 COL11A1 COL18A1 COL2A1 GFAP PDGFB
12 canonical Wnt signaling pathway GO:0060070 9.62 CTNNB1 FZD4 LRP5 NDP
13 positive regulation of neuroblast proliferation GO:0002052 9.61 CTNNB1 VEGFA
14 cartilage condensation GO:0001502 9.6 COL11A1 COL2A1
15 gastrulation with mouth forming second GO:0001702 9.59 CTNNB1 LRP5
16 positive regulation of mesenchymal cell proliferation GO:0002053 9.54 CTNNB1 LRP5 VEGFA
17 proteoglycan metabolic process GO:0006029 9.52 COL11A1 COL2A1
18 retinal blood vessel morphogenesis GO:0061304 9.46 FZD4 LRP5
19 retina vasculature morphogenesis in camera-type eye GO:0061299 9.43 FZD4 LRP5 NDP
20 visual perception GO:0007601 9.43 COL11A1 COL18A1 COL2A1 NDP RHO RS1
21 extracellular matrix-cell signaling GO:0035426 8.8 FZD4 LRP5 NDP
22 multicellular organism development GO:0007275 10.09 ATOH7 FZD4 LRP5 PDGFB RS1 SERPINF1

Molecular functions related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 9.16 PDGFB VEGFA
2 platelet-derived growth factor binding GO:0048407 8.96 COL2A1 PDGFB
3 Wnt-activated receptor activity GO:0042813 8.8 FZD4 LRP5 TSPAN12

Sources for Retinal Detachment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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