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MCID: RTN017
MIFTS: 60

Retinal Detachment

Categories: Eye diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Retinal Detachment

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MalaCards integrated aliases for Retinal Detachment:

Name: Retinal Detachment 57 12 29 54 6 42 44 15 17 71
Retinal Detachments 15

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant


HPO:

31
retinal detachment:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:5327
OMIM® 57 180050
ICD9CM 34 361.9
MeSH 44 D012163
NCIt 50 C26874
SNOMED-CT 67 155103005
ICD10 32 H33.0 H33.2
MedGen 41 C0035305
SNOMED-CT via HPO 68 263681008 42059000
UMLS 71 C0035305
Sources

Summaries for Retinal Detachment

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MedlinePlus : 42 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. It provides the sharp, central vision needed for reading, driving, and seeing fine detail. A retinal detachment lifts or pulls the retina from its normal position. It can occur at any age, but it is more common in people over age 40. It affects men more than women and whites more than African Americans. A retinal detachment is also more likely to occur in people who Are extremely nearsighted Have had a retinal detachment in the other eye Have a family history of retinal detachment Have had cataract surgery Have other eye diseases or disorders Have had an eye injury Symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. It may also seem like there is a "curtain" over your field of vision. A retinal detachment is a medical emergency. If not promptly treated, it can cause permanent vision loss. If you have any symptoms, see an eye care professional immediately. Treatment includes different types of surgery. NIH: National Eye Institute

MalaCards based summary : Retinal Detachment, also known as retinal detachments, is related to persistent hyperplastic primary vitreous, autosomal recessive and vitreoretinopathy, neovascular inflammatory. An important gene associated with Retinal Detachment is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Degradation of the extracellular matrix. The drugs Bevacizumab and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are retinal detachment and cardiovascular system

OMIM® : 57 Primary or spontaneous detachment of the retina occurs due to underlying ocular disease and often involves the vitreous as well as the retina. The precipitating event is formation of a retinal tear or hole, which permits fluid to accumulate under the sensory layers of the retina and creates an intraretinal cleavage that destroys the neurosensory process of visual reception. Vitreoretinal degeneration and tear formation are painless phenomena, and in most cases, significant vitreoretinal pathology is found only after detachment of the retina starts to cause loss of vision or visual field. Without surgical intervention, retinal detachment will almost inevitably lead to total blindness (summary by McNiel and McPherson, 1971). (180050) (Updated 05-Mar-2021)

Wikipedia : 74 Retinal detachment is a disorder of the eye in which the retina separates from the layer underneath.... more...

Sources

Related Diseases for Retinal Detachment

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Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous, autosomal recessive 32.8 TSPAN12 NDP-AS1 ATOH7
2 vitreoretinopathy, neovascular inflammatory 32.7 VEGFA GLUL GFAP
3 kniest dysplasia 32.7 COL9A3 COL2A1 COL11A1
4 stickler syndrome 32.7 COL9A3 COL2A1 COL11A1
5 stickler syndrome, type i 32.5 COL2A1 COL11A1
6 vitreoretinopathy 32.4 TSPAN12 NDP LRP5 FZD4 CTNNB1 COL2A1
7 myopia 32.4 VEGFA SERPINF1 RHO COL2A1 COL11A1
8 exudative vitreoretinopathy 3 32.3 TSPAN12 NDP LRP5 FZD4
9 vitreoretinal degeneration 32.3 COL2A1 COL11A1
10 macular holes 32.3 VEGFA SERPINF1 RS1
11 exudative vitreoretinopathy 32.2 VEGFA TSPAN12 NDP-AS1 NDP LRP5 FZD4
12 coats disease 32.2 VEGFA TSPAN12 RS1 RHO NDP LRP5
13 exudative vitreoretinopathy 4 32.2 TSPAN12 NDP LRP5 FZD4
14 microvascular complications of diabetes 5 32.2 VEGFA SERPINF1 RHO PDGFB
15 exudative vitreoretinopathy 2, x-linked 32.1 NDP-AS1 NDP LRP5 FZD4
16 persistent hyperplastic primary vitreous 32.1 VEGFA TSPAN12 NDP-AS1 NDP LRP5 FZD4
17 microphthalmia 32.1 SERPINF1 NDP LRP5 CTNNB1 ATOH7
18 exudative vitreoretinopathy 1 32.0 VEGFA TSPAN12 SERPINF1 RHO PDGFB NDP
19 vitreous detachment 31.9 VEGFA GFAP COL2A1
20 cataract 31.7 VEGFA SERPINF1 RHO CTNNB1 COL2A1 COL11A1
21 macular retinal edema 31.7 VEGFA SERPINF1 RHO
22 strabismus 31.5 RS1 RHO CTNNB1 COL2A1 COL11A1
23 microvascular complications of diabetes 1 31.5 VEGFA SERPINF1 GFAP
24 diabetic macular edema 31.1 VEGFA SERPINF1 GFAP
25 eye disease 31.0 VEGFA SERPINF1 RS1 RHO NDP COL2A1
26 macular degeneration, age-related, 1 31.0 VEGFA SERPINF1 RS1 RHO GFAP
27 retinal vascular disease 31.0 VEGFA TSPAN12 SERPINF1 RHO NDP LRP5
28 chorioretinal scar 31.0 VEGFA RHO
29 vitreous syneresis 31.0 RS1 COL9A3 COL2A1 COL11A1
30 retinal lattice degeneration 30.9 COL9A3 COL2A1
31 retinal telangiectasia 30.9 VEGFA TSPAN12 NDP FZD4
32 peripheral retinal degeneration 30.8 TSPAN12 RHO COL2A1
33 leukocoria 30.8 TSPAN12 RS1 NDP LRP5 FZD4 ATOH7
34 branch retinal artery occlusion 30.8 VEGFA NDP
35 vitreoretinal dystrophy 30.7 RS1 COL11A1
36 brittle bone disorder 30.7 VEGFA SERPINF1 LRP5 CTNNB1 COL2A1 COL11A1
37 retinal perforation 30.7 VEGFA RS1 COL2A1 COL11A1
38 eales disease 30.7 VEGFA SERPINF1
39 retinitis pigmentosa 30.7 VEGFA SERPINF1 RS1 RHO GLUL GFAP
40 osteoporosis-pseudoglioma syndrome 30.6 NDP LRP5 FZD4 CTNNB1
41 spondyloepiphyseal dysplasia with congenital joint dislocations 30.6 COL9A3 COL2A1 COL11A1
42 norrie disease 30.6 TSPAN12 NDP-AS1 NDP LRP5 FZD4 CTNNB1
43 osteoporosis 30.6 VEGFA NDP LRP5 FZD4 CTNNB1 COL2A1
44 glaucoma, primary open angle 30.5 VEGFA RHO ATOH7
45 preretinal fibrosis 30.5 VEGFA GFAP
46 marshall syndrome 30.4 COL9A3 COL2A1 COL11A1
47 optic nerve hypoplasia, bilateral 30.4 RHO GLUL GFAP ATOH7
48 bullous retinoschisis 30.4 VEGFA RS1
49 brain edema 30.2 VEGFA GLUL GFAP
50 fundus dystrophy 30.1 VEGFA TSPAN12 SERPINF1 RS1 RHO LRP5

Comorbidity relations with Retinal Detachment via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to Retinal Detachment
Sources

Symptoms & Phenotypes for Retinal Detachment

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Human phenotypes related to Retinal Detachment:

31
# Description HPO Frequency HPO Source Accession
1 retinal detachment 31 HP:0000541

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Eyes:
retinal detachment
no myopia

Clinical features from OMIM®:

180050 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Retinal Detachment:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 ATOH7 COL2A1 COL9A3 CTNNB1 FZD4 GFAP
2 nervous system MP:0003631 10.13 ATOH7 COL11A1 COL2A1 CTNNB1 FZD4 GFAP
3 digestive/alimentary MP:0005381 9.97 COL11A1 COL2A1 CTNNB1 FZD4 GFAP PDGFA
4 hearing/vestibular/ear MP:0005377 9.87 COL11A1 COL2A1 COL9A3 CTNNB1 FZD4 NDP
5 normal MP:0002873 9.81 ATOH7 COL2A1 CTNNB1 FZD4 GFAP GLUL
6 pigmentation MP:0001186 9.61 ADAMTSL4 CTNNB1 FZD4 LRP5 NDP PDGFB
7 vision/eye MP:0005391 9.47 ADAMTSL4 ATOH7 COL2A1 CTNNB1 FZD4 GFAP
Sources

Drugs & Therapeutics for Retinal Detachment

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Drugs for Retinal Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
9
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
13
Triazolam Approved, Investigational Phase 4 28911-01-5 5556
14
Rasagiline Approved Phase 4 136236-51-6 3052776
15
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
16
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
17 Sodium Channel Blockers Phase 4
18 Diuretics, Potassium Sparing Phase 4
19 Antineoplastic Agents, Immunological Phase 4
20 Adrenergic alpha-Agonists Phase 4
21 Neurotransmitter Agents Phase 4
22 Adrenergic Agents Phase 4
23 Adrenergic Agonists Phase 4
24 Anesthetics, Intravenous Phase 4
25 Anesthetics, General Phase 4
26 Immunoglobulins Phase 4
27 Antibodies Phase 4
28 Immunoglobulin G Phase 4
29 Immunoglobulins, Intravenous Phase 4
30 Immunologic Factors Phase 4
31 Immunosuppressive Agents Phase 4
32 Methylprednisolone Acetate Phase 4
33 Anesthetics Phase 4
34 Proxymetacaine Phase 4
35 Hypnotics and Sedatives Phase 4
36 Protective Agents Phase 4
37 Neuroprotective Agents Phase 4
38 Monoamine Oxidase Inhibitors Phase 4
39 Antirheumatic Agents Phase 4
40 Analgesics, Non-Narcotic Phase 4
41 Analgesics Phase 4
42 Ketorolac Tromethamine Phase 4
43 Anti-Inflammatory Agents, Non-Steroidal Phase 4
44 Cyclooxygenase Inhibitors Phase 4
45
Colchicine Approved Phase 3 64-86-8 6167 2833
46
Povidone-iodine Approved Phase 3 25655-41-8
47
Iodine Approved, Investigational Phase 3 7553-56-2 807
48
Povidone Approved Phase 3 9003-39-8 131751496
49
Dalteparin Approved Phase 3 9005-49-6
50
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414

Interventional clinical trials:

(show top 50) (show all 159)
# Name Status NCT ID Phase Drugs
1 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
2 Transpupillary Thermotherapy (TTT) Alone Versus the Combined Therapy Consisting of TTT and Intravitreal Injection of Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy Unknown status NCT02379000 Phase 4 Triamcinolone Acetonide
3 On-label tReatment With Intravitreal Aflibercept Injection for Patients With Persistent Pigment Epithelial Detachments in Neovascular AMD. Unknown status NCT01670162 Phase 4 Aflibercept
4 The Effects of Triamcinolone Acetonide With Retrobulbar Anesthesia on Postoperative Pain Control Following Vitreoretinal Surgery Completed NCT01995045 Phase 4 Triamcinolone;Bupivicaine Hydrochloride
5 Comparison of Dexmedetomidine vs. Propofol in Vitreoretinal Surgery Under Sub-Tenon's Block Completed NCT01001429 Phase 4 Dexmedetomidine infusion;propofol
6 Prospective Randomized Controlled Study of Intravitreal Injection of 0.16 mg Bevacizumab One Day Before Surgery for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab
7 Open Label Study: Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment. Completed NCT01722656 Phase 4 Aflibercept
8 A 12-month, Exploratory Open-label Study of Eylea (Aflibercept) in Subjects With Retinal Pigment Epithelial Detachment Secondary to Neovascular Age-related Macular Degeneration Completed NCT02142296 Phase 4 Eylea
9 Different Conbercept Injection Methods in Treatment of Severe Proliferative Diabetic Retinopathy Completed NCT02816710 Phase 4 Conbercept
10 Intravitreal Ranibizumab in Patients With Retinal Pigment Epithelial Detachments Secondary to Age-related Macular Degeneration Completed NCT00976222 Phase 4 intravitreal injection with ranibizumab
11 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
12 Using Intraoperative Triamcinolone Acetonide Irrigation to Reduce Post-Operative Pain From Scleral Buckle Surgery Recruiting NCT04701593 Phase 4 Triamcinolone Acetonide 40mg/mL
13 Assessing the Efficacy and Safety of DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert, When Placed Within the Lower Eye Lid Canaliculus in Pseudo Phakic Patients Undergoing Gas Bubble Repair and Laser Following Retinal Detachment Recruiting NCT04464629 Phase 4 Dextenza;Prednisolone Acetate
14 Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block Not yet recruiting NCT04346095 Phase 4 Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
15 Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment Terminated NCT02068625 Phase 4 Rasagiline;Placebo
16 Topical Application of ACULAR a Randomized, Vehicle Controlled Clinical Trial: Efficiency in Inhibiting Proliferative Retinopathy of Prematurity Terminated NCT00634972 Phase 4 ACULAR;REFRESH TEARS;placebo
17 Effect of Dexamethasone on Postoperative Symptoms of Scleral Buckling Surgery Patients: a Randomized Control Trial Withdrawn NCT01326585 Phase 4 Dexamethasone Sodium Phosphate Injection;Saline Injection
18 This is an Open Label Study to Evaluate the Efficacy of Intravitreal Aflibercept Injection 2mg in Patients With a Persistent FVPED Despite at Least 6 Consecutive Injections With Ranibizumab 0.5 mg Withdrawn NCT01495208 Phase 4 Aflibercept
19 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy. Withdrawn NCT01666236 Phase 4
20 Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment Unknown status NCT00370201 Phase 3 colchicine
21 Comparison of Two High-Density Silicone Oils in Complicated Rhegmatogenous Retinal Detachment Unknown status NCT00403702 Phase 2, Phase 3 Oxane HD [oil-RMN3-mixture];Densiron [(F6H8)
22 Pressurized Perfluorocarbon Perfused 23 GA Vitrectomy in Complicated Diabetic Retinal Detachment Unknown status NCT00404209 Phase 3
23 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
24 Comparison of Air and Expansile Gas in Pneumatic Retinopexy Completed NCT00120445 Phase 3
25 Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy: Results of the Pan-American Collaborative Retina Study (PACORES) Group Completed NCT01976923 Phase 3 Intravitreal bevacizumab
26 Randomized Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation for Retinopexy in Scleral Buckle Surgery Completed NCT01068379 Phase 3
27 Determining Optimal Treatment Algorithms for Macular Degeneration Pigment Epithelial Detachments Treated With Intraocular Lucentis Completed NCT00590694 Phase 2, Phase 3 ranibizumab
28 Diabetic Retinopathy Vitrectomy Study (DRVS) Completed NCT00000154 Phase 3
29 The Silicone Study Completed NCT00000140 Phase 3 Perfluoropropane;Sulfur Hexafluoride;Silicone Oil
30 Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment. Active, not recruiting NCT02834559 Phase 3 5-fluorouracil and low molecular weight heparin;Placebo
31 A Phase III Randomized 1:1, Masked, Study of the Safety, Tolerability, and Efficacy of Intravitreal Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Adjuvant Management of TRD and Vit Hem Associated With PDR Withdrawn NCT01589718 Phase 3 Macugen;Sham
32 Perfluorocarbon Gases for the Repair of Retinal Detachments. Unknown status NCT00161525 Phase 2
33 Evaluation of Minocycline Neuro Protective Role in Retinal Detachment Surgery Unknown status NCT01297816 Phase 2 placebo;Minocycline
34 Safety and Efficacy of Brimonidine Tartrate Posterior Segment Drug Delivery System in Improving Visual Function Completed NCT00972374 Phase 2 400 ug Brimonidine Implant;200 ug Brimonidine Implant
35 The Effect of Intravitreous Ranibizumab on Intra-Operative Bleeding During Pars Plana Vitrectomy for Diabetic Traction Retinal Detachment Completed NCT01201161 Phase 2 Ranibizumab
36 Pars Plana Vitrectomy (PPV) Versus Preoperative Intravitreal Bevacizumab Plus PPV for Diabetic Tractional Retinal Detachment (IBETRA Study) Completed NCT00690768 Phase 2 Bevacizumab
37 Intravitreal Lucentis (iL) (Ranibizumab) for the Treatment of AMD Related Pigment Epithelial Detachment (PED) Completed NCT00841581 Phase 2 Ranibizumab
38 A Multi-Center, Randomized, Sham-Controlled, Phase II Trial Evaluating Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Macula Off Rhegmatogenous Retinal Detachment Repair (The PREVENT-PVR Trial) Recruiting NCT04580147 Phase 2 Intravitreal aflibercept injection
39 Head Positioning Duration After Retinal Detachment Repair With Vitrectomy and Gas Recruiting NCT03714503 Phase 2
40 Bevacizumab Against Recurrent Retinal Detachment Active, not recruiting NCT02192970 Phase 2 Bevacizumab
41 Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome : a Randomized Controlled Trial Not yet recruiting NCT04465188 Phase 2
42 A Randomized, Double-Masked, Placebo Controlled, Parallel Group, Multi-Center, Dose-Ranging Study of Denufosol Tetrasodium (INS37217) Intravitreal Injection in Subjects With Rhegmatogenous Retinal Detachment Terminated NCT00083967 Phase 2 denufosol tetrasodium (INS37217) Intravitreal Injection
43 High Dose Lucentis for Persistent Pigment Epithelial Detachment in Neovascular Age-related Macular Degeneration - The HiPED Study Terminated NCT01189019 Phase 2 ranibizumab;ranibizumab
44 The Multi-center Exploratory Clinical Trials for the Evaluation of Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment Unknown status NCT01261533 Phase 1
45 A Double-Masked, Randomized, Dose-Ranging Study of a Single Intravitreal (IVT) Injection of INS37217 Intravitreal Injection in Subjects With Retinal Detachment Completed NCT00210067 Phase 1 denufosol tetrasodium (INS37217) Intravitreal Injection
46 Ursodeoxycholic Acid (UDCA) as Adjuvant Treatment for Rhegmatogenous Retinal Detachment: a Phase I Pilot Study Completed NCT02841306 Phase 1 Ursodeoxycholic Acid
47 Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment Completed NCT00548197 Phase 1 Bevacizumab
48 A Single-Center Trial of Intravitreous Injections of Macugen (Pegaptanib Sodium) Given at Least 7 Days Before Vitrectomy Secondary To Tractional Retinal Detachment in Proliferative Diabetic Retinopathy Completed NCT01487070 Phase 1 Macugen (Pegaptanib Sodium)
49 Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment Completed NCT01454466 Phase 1
50 A Phase I Study to Evaluate the Efficacy and Safety of Treating Subfoveal Pigment Epithelial Detachment Associated With Choroidal Neovascularization With Anti-vascular Endothelial Growth Factor Fragment, Ranibizumab. Completed NCT00749021 Phase 1 Ranibizumab;Ranibizumab;Ranibizumab;Ranibizumab

Search NIH Clinical Center for Retinal Detachment

Cochrane evidence based reviews: retinal detachment

Sources

Genetic Tests for Retinal Detachment

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Genetic tests related to Retinal Detachment:

# Genetic test Affiliating Genes
1 Retinal Detachment 29
Sources

Anatomical Context for Retinal Detachment

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MalaCards organs/tissues related to Retinal Detachment:

40
Eye, Retina, Endothelial, Bone, Brain, Lung, Breast
Sources

Publications for Retinal Detachment

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Articles related to Retinal Detachment:

(show top 50) (show all 19192)
# Title Authors PMID Year
1
Surgical outcomes and prognostic factors following vitrectomy in acquired immune deficiency syndrome patients with cytomegalovirus retinitis-related retinal detachment. 42 61
33120835 2020
2
Rupture of the Globe: What to Do, What not to Do. 61 42
32967031 2020
3
Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability. 42
32985592 2020
4
Vitreous levels of VEGF, IL-8, and TNF-alpha in retinal detachment. 61 54
20465445 2010
5
Effects of intraocular ranibizumab and bevacizumab in transgenic mice expressing human vascular endothelial growth factor. 61 54
19643496 2009
6
The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisis. 61 54
19387072 2009
7
Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti-VEGF administration. 61 54
19657986 2009
8
Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment. 61 54
18815803 2009
9
Treatment of total exudative retinal detachment due to central retinal vein occlusion by intravitreal bevacizumab in a patient with p-ANCA vasculitis. 61 54
19668494 2007
10
Detection of PEDF in subretinal fluid of retinal detachment: possible role in the prevention of subretinal neovascularization. preliminary results. 61 54
16679806 2006
11
Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening. 54 61
16679807 2006
12
Association of genetic polymorphisms of vascular endothelial growth factor and risk for proliferative retinopathy of prematurity. 61 54
15635051 2005
13
High TGF-beta2 levels during primary retinal detachment may protect against proliferative vitreoretinopathy. 61 54
15505063 2004
14
A case of Kniest dysplasia with retinal detachment and the mutation analysis. 61 54
14644246 2003
15
Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity. 61 54
14507768 2003
16
Diabetic patients and retinal proliferation: an evaluation of the role of vascular endothelial growth factor (VEGF). 54 61
12845559 2003
17
Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment. 54 61
12670875 2003
18
Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. 54 61
14692684 2003
19
Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy. 54 61
12208248 2002
20
Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window. 61 54
11914216 2002
21
Levels of basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in subretinal fluid from patients with retinal detachment. 54 61
11589877 2001
22
Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. 61 54
11264138 2001
23
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. 54 61
11110038 2000
24
Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment. 61 54
10980138 2000
25
Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy. 61 54
11148602 2000
26
Fibrinolytic activity of subretinal fluid after cryopexy. 61 54
10651193 1999
27
Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. 54 61
10067974 1999
28
Elevated vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. 61 54
12579655 1999
29
Ocular complications and a new surgical approach to lens dislocation in homocystinuria due to cystathionine-beta-synthetase deficiency. 54 61
9587034 1998
30
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. 54 61
9499769 1998
31
[Concentration of vascular endothelial growth factor within the subretinal space and vitreous fluid in rhegmatogenous retinal detachment]. 54 61
9209137 1997
32
[Biological activity of subretinal fluid in selected in vitro tests]. 61 54
9685781 1997
33
Blood-ocular barrier breakdown in eyes with ocular melanoma. A potential role for vascular endothelial growth factor/vascular permeability factor. 54 61
7485392 1995
34
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. 54 61
7540233 1995
35
Glial fibrillary acidic protein and its mRNA: ultrastructural detection and determination of changes after CNS injury. 61 54
1486005 1992
36
Cytokines in proliferative vitreoretinopathy. 61 54
1800167 1991
37
The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery. 61
33510064 2021
38
Genotype variant screening and phenotypic analysis of FBN1 in Chinese patients with isolated ectopia lentis. 61
33576469 2021
39
Simultaneous Bilateral Serous Retinal Detachments and Cortical Visual Loss in the PRES HELLP Syndrome. 61
32235215 2021
40
Headache and Bilateral Optic Disc Edema as the Initial Manifestation of Vogt-Koyanagi-Harada Disease. 61
32102009 2021
41
Intracranial migration of intraocular silicone oil mimicking metastatic disease. 61
33456636 2021
42
Transient Macular Thinning during the Use of Heavy Silicone Oil, Densiron 68. 61
32700981 2021
43
Commentary: Pars plana vitrectomy for acute retinal necrosis related rhegmatogenous retinal detachment. 61
33595492 2021
44
Impact of contact versus non-contact wide-angle viewing systems on outcomes of primary retinal detachment repair (PRO study report number 5). 61
32409294 2021
45
Outcomes of 25-gauge pars plana vitrectomy with encircling scleral band for acute retinal necrosis-related rhegmatogenous retinal detachment. 61
33595491 2021
46
APPLICATION OF MODIFIED NEI VFQ-25 AFTER RETINAL DETACHMENT TO VISION-RELATED QUALITY OF LIFE. 61
32568989 2021
47
A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades. 61
32806983 2021
48
RETINAL DETACHMENT WITH INFERIOR RETINAL BREAKS: Primary Vitrectomy Versus Vitrectomy With Scleral Buckle (PRO Study Report No. 9). 61
33600131 2021
49
Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels. 61
33144182 2021
50
Intraocular silicone oil brain migration associated with severe subacute headaches: a case report. 61
33588944 2021
Sources

Variations for Retinal Detachment

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ClinVar genetic disease variations for Retinal Detachment:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RHO NM_000539.3(RHO):c.891C>G (p.Ser297Arg) SNV Pathogenic 523376 rs142285818 3:129251570-129251570 3:129532727-129532727
2 COL2A1 NM_001844.5(COL2A1):c.842_843insT (p.Gly282fs) Insertion Pathogenic 812293 rs1592230091 12:48387804-48387805 12:47994021-47994022
3 COL9A3 NM_001853.4(COL9A3):c.1107+1G>C SNV Likely pathogenic 973782 20:61461034-61461034 20:62829682-62829682
4 COL9A3 NM_001853.4(COL9A3):c.388G>A (p.Gly130Ser) SNV Likely pathogenic 392918 rs139401633 20:61453127-61453127 20:62821775-62821775
5 NDP-AS1 NM_000266.4(NDP):c.308_311dup (p.Lys104fs) Duplication Likely pathogenic 523342 rs1555976049 X:43809135-43809136 X:43949889-43949890
6 EYS NM_001142800.2(EYS):c.4152del (p.Pro1385fs) Deletion Uncertain significance 523414 rs1185686653 6:65301608-65301608 6:64591715-64591715
Sources

Expression for Retinal Detachment

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Search GEO for disease gene expression data for Retinal Detachment.
Sources

Pathways for Retinal Detachment

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Pathways related to Retinal Detachment according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.65 VEGFA PDGFB PDGFA LRP5 FZD4 CTNNB1
2
Degradation of the extracellular matrix 65
Show member pathways
 12.56 PDGFB PDGFA COL9A3 COL2A1 COL11A1
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.54 VEGFA PDGFB PDGFA FZD4 CTNNB1 COL9A3
4
Pathways in cancer 36
12.52 VEGFA PDGFB PDGFA LRP5 FZD4 CTNNB1
5
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.28 PDGFB PDGFA FZD4 CTNNB1
6
Colorectal Cancer Metastasis 63
12.01 VEGFA LRP5 FZD4 CTNNB1
7
Focal Adhesion 36 1
Show member pathways
 11.99 VEGFA RHO PDGFB PDGFA CTNNB1 COL9A3
8
Wnt signaling pathway 36
11.96 SERPINF1 LRP5 FZD4 CTNNB1
9
Fluid shear stress and atherosclerosis 36
11.85 VEGFA PDGFB PDGFA CTNNB1
10
Neural Crest Differentiation 1
11.73 GFAP CTNNB1 COL2A1
11
Glioblastoma Multiforme 63
11.6 PDGFB PDGFA FZD4 CTNNB1
12
Differentiation Pathway 1
11.33 VEGFA PDGFB PDGFA
13
Vemurafenib Pathway, Pharmacodynamics 60
11.24 VEGFA PDGFB PDGFA
14
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.15 VEGFA PDGFB PDGFA GFAP
15
G-protein signaling_Rap2B regulation pathway 23
10.75 PDGFB PDGFA GFAP COL9A3 COL2A1 COL11A1
Sources

GO Terms for Retinal Detachment

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Cellular components related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 VEGFA SERPINF1 RS1 PDGFB PDGFA NDP
2 extracellular space GO:0005615 9.96 VEGFA SERPINF1 RS1 PDGFB PDGFA NDP
3 basement membrane GO:0005604 9.65 SERPINF1 COL9A3 COL2A1
4 collagen trimer GO:0005581 9.63 COL9A3 COL2A1 COL11A1
5 endoplasmic reticulum lumen GO:0005788 9.63 PDGFB PDGFA COL9A3 COL2A1 COL11A1 ADAMTSL4
6 platelet alpha granule lumen GO:0031093 9.54 VEGFA PDGFB PDGFA
7 glial cell projection GO:0097386 9.43 GLUL GFAP
8 extracellular matrix GO:0031012 9.43 VEGFA NDP COL9A3 COL2A1 COL11A1 ADAMTSL4
9 Wnt signalosome GO:1990909 9.4 LRP5 CTNNB1
10 collagen-containing extracellular matrix GO:0062023 9.17 SERPINF1 PDGFB NDP COL9A3 COL2A1 COL11A1

Biological processes related to Retinal Detachment according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.1 VEGFA RS1 PDGFB PDGFA LRP5 FZD4
2 positive regulation of cell proliferation GO:0008284 10.02 VEGFA PDGFB PDGFA LRP5 CTNNB1
3 nervous system development GO:0007399 10.01 VEGFA NDP LDB2 CTNNB1 ATOH7
4 angiogenesis GO:0001525 9.91 VEGFA TSPAN12 PDGFA GLUL
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.79 VEGFA PDGFB PDGFA
6 positive regulation of MAPK cascade GO:0043410 9.78 VEGFA PDGFB PDGFA CTNNB1
7 response to wounding GO:0009611 9.77 PDGFB PDGFA GFAP
8 Wnt signaling pathway GO:0016055 9.77 TSPAN12 NDP LRP5 FZD4 CTNNB1
9 canonical Wnt signaling pathway GO:0060070 9.76 LRP5 FZD4 CTNNB1
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.76 NDP LRP5 FZD4 CTNNB1
11 vasculogenesis GO:0001570 9.74 VEGFA FZD4 CTNNB1
12 positive regulation of MAP kinase activity GO:0043406 9.72 VEGFA PDGFB PDGFA
13 visual perception GO:0007601 9.72 RS1 RHO NDP COL2A1 COL11A1
14 heart morphogenesis GO:0003007 9.7 VEGFA COL2A1 COL11A1
15 positive regulation of cell division GO:0051781 9.69 VEGFA PDGFB PDGFA
16 gastrulation with mouth forming second GO:0001702 9.63 LRP5 CTNNB1
17 positive regulation of DNA biosynthetic process GO:2000573 9.63 VEGFA PDGFB
18 negative regulation of platelet activation GO:0010544 9.59 PDGFB PDGFA
19 proteoglycan metabolic process GO:0006029 9.58 COL2A1 COL11A1
20 positive regulation of protein autophosphorylation GO:0031954 9.58 VEGFA PDGFB PDGFA
21 retinal blood vessel morphogenesis GO:0061304 9.54 LRP5 FZD4
22 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.49 PDGFB PDGFA
23 negative regulation of phosphatidylinositol biosynthetic process GO:0010512 9.43 PDGFB PDGFA
24 retina vasculature morphogenesis in camera-type eye GO:0061299 9.43 NDP LRP5 FZD4
25 extracellular matrix-cell signaling GO:0035426 9.33 NDP LRP5 FZD4
26 positive regulation of mesenchymal cell proliferation GO:0002053 9.26 VEGFA PDGFA LRP5 CTNNB1
27 extracellular matrix organization GO:0030198 9.17 PDGFB PDGFA GFAP COL9A3 COL2A1 COL11A1

Molecular functions related to Retinal Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.43 COL9A3 COL2A1 COL11A1
2 Wnt-activated receptor activity GO:0042813 9.33 TSPAN12 LRP5 FZD4
3 growth factor receptor binding GO:0070851 9.32 PDGFB PDGFA
4 platelet-derived growth factor receptor binding GO:0005161 9.13 VEGFA PDGFB PDGFA
5 platelet-derived growth factor binding GO:0048407 8.8 PDGFB PDGFA COL2A1
Sources

Sources for Retinal Detachment

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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