MCID: RTN003
MIFTS: 52

Retinal Ischemia

Categories: Blood diseases, Eye diseases

Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 38 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12510
ICD10 33 H35.82
ICD9CM 35 362.84
SNOMED-CT 68 26468004
UMLS 73 C0162291

Summaries for Retinal Ischemia

MalaCards based summary : Retinal Ischemia is related to ischemia and eales disease. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bevacizumab and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.6 BCL2 CASP3 CXCL12 HIF1A KNG1 SOD1
2 eales disease 29.5 SOD1 TNF VEGFA
3 exudative vitreoretinopathy 1 11.0
4 exudative vitreoretinopathy 2, x-linked 11.0
5 exudative vitreoretinopathy 4 11.0
6 exudative vitreoretinopathy 3 11.0
7 age-related hearing loss 10.2 HIF1A SETD2
8 meningitis and encephalitis 10.1 CAT SOD1
9 intravascular papillary endothelial hyperplasia 10.1 HIF1A VEGFA
10 aids dementia complex 10.1 CXCL12 TNF
11 microvascular complications of diabetes 5 10.1
12 retinal vein occlusion 10.1
13 anthracosis 10.1 SOD1 TNF
14 critical limb ischemia 10.1 TNF VEGFA
15 erysipelas 10.0 CAT SOD1 TNF
16 progressive multifocal leukoencephalopathy 10.0 BCL2 HIF1A TNF
17 pneumoconiosis 10.0 CAT SOD1 TNF
18 retinal hemangioblastoma 10.0 CXCL12 HIF1A VEGFA
19 female reproductive system disease 10.0 CASP3 TNF VEGFA
20 reproductive system disease 10.0 CASP3 TNF VEGFA
21 intestinal disease 10.0 CASP3 TNF VEGFA
22 respiratory system disease 10.0 CASP3 TNF VEGFA
23 gastrointestinal system cancer 10.0 CASP3 TNF VEGFA
24 gastrointestinal system disease 10.0 CASP3 TNF VEGFA
25 central nervous system disease 10.0 CASP3 SOD1 TNF
26 ovarian disease 10.0 CASP3 TNF VEGFA
27 huntington disease 10.0 CASP2 CASP3 SETD2 SOD1
28 kashin-beck disease 10.0 BCL2 TNF VEGFA
29 neurofibromatosis, type i 10.0
30 central retinal artery occlusion 10.0
31 macular retinal edema 10.0
32 retinal artery occlusion 10.0
33 radiation proctitis 9.9 TNF VEGFA
34 soft tissue sarcoma 9.9 BCL2 TNF VEGFA
35 arteries, anomalies of 9.9 KNG1 TNF VEGFA
36 limb ischemia 9.9 CXCL12 HIF1A TNF VEGFA
37 dystrophinopathies 9.9 APAF1 CASP2 TNF
38 brain edema 9.9 KNG1 SOD1 VEGFA
39 brain cancer 9.9 CASP3 HIF1A HSPB1 VEGFA
40 myeloma, multiple 9.9 CASP3 CXCL12 TNF VEGFA
41 breast disease 9.9 CASP3 CAT TNF VEGFA
42 nervous system disease 9.9 CASP3 SOD1 TNF VEGFA
43 poems syndrome 9.9 TNF VEGFA
44 temporal arteritis 9.9
45 cataract 9.9
46 neovascular glaucoma 9.9
47 ocular hypertension 9.9
48 hypoxia 9.9
49 adamantinoma of long bones 9.9 BCL2 CASP3 HIF1A VEGFA
50 large intestine cancer 9.8 CASP3 CXCL12 HIF1A TNF VEGFA

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 APAF1 BCL2 CASP3 HIF1A NFKB1 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 APAF1 BCL2 CASP3 HIF1A NFKB1 SOD1
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CASP2 CASP3 CAT TNF

MGI Mouse Phenotypes related to Retinal Ischemia:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 APAF1 BCL2 CASP2 CASP3 CAT CXCL12
2 cardiovascular system MP:0005385 10.29 APAF1 BCL2 CASP3 CXCL12 HIF1A HSPB1
3 growth/size/body region MP:0005378 10.29 APAF1 BCL2 CASP3 HIF1A HSPB1 KNG1
4 immune system MP:0005387 10.27 APAF1 BCL2 CASP2 CASP3 CXCL12 HIF1A
5 hematopoietic system MP:0005397 10.26 BCL2 CASP2 CASP3 CXCL12 HIF1A HSPB1
6 endocrine/exocrine gland MP:0005379 10.21 APAF1 BCL2 CASP2 CASP3 HIF1A NFKB1
7 homeostasis/metabolism MP:0005376 10.21 BCL2 CASP3 CAT HIF1A HSPB1 NFKB1
8 mortality/aging MP:0010768 10.21 APAF1 BCL2 CASP2 CASP3 CAT CXCL12
9 craniofacial MP:0005382 10.18 APAF1 BCL2 CASP3 HIF1A NFKB1 SETD2
10 digestive/alimentary MP:0005381 10.11 APAF1 BCL2 CASP3 HIF1A NFKB1 TNF
11 nervous system MP:0003631 10.06 APAF1 BCL2 CASP2 CASP3 CXCL12 HIF1A
12 integument MP:0010771 10.02 BCL2 CASP3 HIF1A NFKB1 SOD1 TNF
13 muscle MP:0005369 10.01 BCL2 CASP3 CXCL12 HIF1A NFKB1 SOD1
14 neoplasm MP:0002006 9.97 APAF1 BCL2 CAT HIF1A SETD2 SOD1
15 hearing/vestibular/ear MP:0005377 9.93 APAF1 BCL2 CASP3 NFKB1 SOD1
16 liver/biliary system MP:0005370 9.93 CXCL12 HIF1A NFKB1 SOD1 TNF VEGFA
17 reproductive system MP:0005389 9.86 APAF1 BCL2 CASP2 CASP3 CXCL12 SOD1
18 respiratory system MP:0005388 9.63 APAF1 CASP3 HIF1A NFKB1 TNF VEGFA
19 skeleton MP:0005390 9.56 APAF1 CASP3 HIF1A NFKB1 SETD2 SOD1
20 vision/eye MP:0005391 9.23 APAF1 BCL2 CASP3 HIF1A SETD2 SOD1

Drugs & Therapeutics for Retinal Ischemia

Drugs for Retinal Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Warfarin Approved Phase 4 81-81-2 6691 54678486
3
Ranibizumab Approved Phase 4,Phase 1,Phase 2 347396-82-1 459903
4
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
5 Immunoglobulins Phase 4,Phase 3
6 Antibodies Phase 4,Phase 3
7 Angiogenesis Inhibitors Phase 4,Phase 1,Phase 2
8 Angiogenesis Modulating Agents Phase 4,Phase 1,Phase 2
9 Dabigatran Phase 4,Not Applicable
10
protease inhibitors Phase 4,Not Applicable
11 Anticoagulants Phase 4,Not Applicable
12 Antithrombin III Phase 4,Not Applicable
13 HIV Protease Inhibitors Phase 4,Not Applicable
14 Antithrombins Phase 4,Not Applicable
15 Serine Proteinase Inhibitors Phase 4,Not Applicable
16 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
17
Aspirin Approved, Vet_approved Phase 3,Not Applicable 50-78-2 2244
18
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
20 Antibodies, Monoclonal Phase 3
21 Platelet Aggregation Inhibitors Phase 3,Not Applicable
22 Purinergic P2Y Receptor Antagonists Phase 3
23 Purinergic P2 Receptor Antagonists Phase 3
24 Neurotransmitter Agents Phase 3
25
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
26
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
27
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
28
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
29
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
30 Antineoplastic Agents, Hormonal Phase 1, Phase 2
31 Anti-Inflammatory Agents Phase 1, Phase 2,Not Applicable
32 Hormone Antagonists Phase 1, Phase 2
33 Epoetin alfa Phase 1, Phase 2 113427-24-0
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
35 Gastrointestinal Agents Phase 1, Phase 2
36 Prednisolone acetate Phase 1, Phase 2
37 Methylprednisolone acetate Phase 1, Phase 2
38 Antiemetics Phase 1, Phase 2
39 Autonomic Agents Phase 1, Phase 2
40 Neuroprotective Agents Phase 1, Phase 2
41 Peripheral Nervous System Agents Phase 1, Phase 2,Not Applicable
42 Hematinics Phase 1, Phase 2
43 glucocorticoids Phase 1, Phase 2
44 Hormones Phase 1, Phase 2
45 Protective Agents Phase 1, Phase 2
46 Mitogens Phase 1, Phase 2
47 Endothelial Growth Factors Phase 1, Phase 2
48 Edoxaban Approved Not Applicable 480449-70-5
49
Rivaroxaban Approved Not Applicable 366789-02-8
50
Apixaban Approved Not Applicable 503612-47-3 10182969

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) Unknown status NCT02432547 Phase 4 Aflibercept
2 Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
3 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA Completed NCT03246152 Phase 4 Bevacizumab
4 Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT) Completed NCT02348723 Phase 4 Warfarin;Dabigatran Etexilate 150mg
5 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
6 Oxygen Therapy for Retinal Ischemia Enrolling by invitation NCT03730779 Phase 4 Hyperoxia
7 Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Completed NCT01764633 Phase 3 Placebo
8 Aspirin to Target Arterial Events in Chronic Kidney Disease Not yet recruiting NCT03796156 Phase 3 Aspirin
9 Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Terminated NCT00991029 Phase 3 Clopidogrel;placebo
10 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Unknown status NCT02957760 Phase 2 Hydroxycarbamid
11 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
12 Traumatic Optic Neuropathy Treatment Trial (TONTT) Completed NCT01783847 Phase 1, Phase 2 Recombinant human erythropoietin (EPO);Methyl prednisolone
13 Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy. Recruiting NCT02151695 Phase 2 Aflibercept intravitreal injections
14 Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy. Active, not recruiting NCT02222610 Phase 2 0.5 mg ranibizumab
15 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
16 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
17 Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab Completed NCT01360385
18 Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device) Completed NCT01546766
19 Pediatric Type 1 Diabetes and Retinopathy Completed NCT02691312
20 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
21 Electronic Alerts for Stroke Prevention in Patients With Atrial Fibrillation or Atrial Flutter Completed NCT02339493 Not Applicable
22 Ultra-wide Fluorescein Angiography in Patients With Central Retinal Vein Occlusion Treated by Afilbercept Recruiting NCT02880644
23 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Recruiting NCT03061526
24 Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes Recruiting NCT02876744
25 Detecting the Influence of Cataract Surgery on the Development of Diabetic Retinopathy in Patients With Diabetes Mellitus Type 2 With and Without Diabetic Retinopathy Using OCT Angiography Recruiting NCT03571139
26 Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus Recruiting NCT03422965 Not Applicable
27 Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV) Recruiting NCT03525132 Not Applicable
28 Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation Recruiting NCT03642509 Not Applicable NOAC
29 Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module Active, not recruiting NCT03530449
30 Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation Not yet recruiting NCT03232450 Not Applicable Aspirin
31 Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial Terminated NCT00379223 Not Applicable

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 23049424 21225138 19347139 23000646

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

MalaCards organs/tissues related to Retinal Ischemia:

41
Eye, Endothelial, Bone, Retina, Brain, T Cells, B Cells

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 330)
# Title Authors Year
1
Carotid ergotism with retinal ischemia. ( 29708216 )
2018
2
Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion. ( 29942024 )
2018
3
PROGRESSION OF RETINAL ISCHEMIA IN A CASE OF MACULAR TELANGIECTASIA TYPE 1 AFTER RANIBIZUMAB INJECTION: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS. ( 29443804 )
2018
4
Low-dose minocycline mediated neuroprotection on retinal ischemia-reperfusion injury of mice. ( 29853771 )
2018
5
A Model for Graded Retinal Ischemia in Rats. ( 29881647 )
2018
6
Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits. ( 29323543 )
2018
7
The effects of bevacizumab treatment in a rat model of retinal ischemia and perfusion injury. ( 29681725 )
2018
8
Fewer Functional Deficits and Reduced Cell Death after Ranibizumab Treatment in a Retinal Ischemia Model. ( 29857531 )
2018
9
Management of Acute Retinal Ischemia: Follow the Guidelines! ( 29716787 )
2018
10
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. ( 29552298 )
2018
11
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. ( 29111459 )
2018
12
Ocular Blood Flow in Rabbits under Deep Anesthesia: A Real-Time Measurement Technique and Its Application in Characterizing Retinal Ischemia. ( 29632320 )
2018
13
Use of OCTA, FA, and Ultra-Widefield Imaging in Quantifying Retinal Ischemia: A Review. ( 29436208 )
2018
14
Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation. ( 30359965 )
2018
15
Multimodal imaging in acute retinal ischemia: spectral domain OCT, OCT-angiography and fundus autofluorescence. ( 30225228 )
2018
16
The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury. ( 30174588 )
2018
17
Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia. ( 29106899 )
2018
18
Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia. ( 28823941 )
2017
19
Application of Arterial Spin Labelling in Detecting Retinal Ischemia. ( 29422857 )
2017
20
Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. ( 29296071 )
2017
21
Dexmedetomidine preconditioning protects against retinal ischemia/reperfusion injury and inhibits inflammation response via toll-like receptor 4 (TLR4) pathway. ( 28724211 )
2017
22
Pioglitazone ameliorates retinal ischemia/reperfusion injury<i>via</i>suppressing NLRP3 inflammasome activities. ( 29259897 )
2017
23
Resveratrol Ameliorates Retinal Ischemia/Reperfusion Injury in C57BL/6J Mice via Downregulation of Caspase-3. ( 28985092 )
2017
24
Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1I+ and VEGF via inhibition of RBP2 and PKM2. ( 28709426 )
2017
25
Letter by Kawada Regarding Article, &amp;quot;Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study&amp;quot;. ( 28626051 )
2017
26
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
27
OCT Angiography: Assessment of Retinal Ischemia in Susac's Syndrome. ( 28613358 )
2017
28
Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice. ( 28210901 )
2017
29
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. ( 28386036 )
2017
30
Curcumin protects against hypertension aggravated retinal ischemia/reperfusion in a rat stroke model. ( 28678631 )
2017
31
Neuroprotective effects of a novel peptide, FK18, under oxygen-glucose deprivation in SH-SY5Y cells and retinal ischemia in ratsA viaA the Akt pathway. ( 28257830 )
2017
32
Neurosurgical Modeling of Retinal Ischemia-Reperfusion Injury. ( 29196198 )
2017
33
Response by Golsari and Thomalla to Letter Regarding Article, &amp;quot;Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study&amp;quot;. ( 28626060 )
2017
34
Thrombolyic and Vasodilator Treatment in a Patient With Prolonged Retinal Ischemia. ( 28471897 )
2017
35
Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats. ( 28523456 )
2017
36
Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia. ( 28636406 )
2017
37
Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents. ( 28335564 )
2017
38
Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model. ( 28878627 )
2017
39
Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In Vitro and Attenuates Retinal Ischemia/Reperfusion Injury In Vivo against Oxidative Stress. ( 28255307 )
2017
40
Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury. ( 28063877 )
2017
41
Utility of optical coherence tomography in the evaluation of monocular visual loss related to retinal ischemia. ( 26765759 )
2016
42
Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. ( 27158842 )
2016
43
The protective effect of prophylactic ozone administration against retinal ischemia-reperfusion injury. ( 27028056 )
2016
44
Peripheral retinal ischemia in a young Indian woman with neurofibromatosis type 1. ( 26949362 )
2016
45
Functional and Structural Evaluation of Sildenafil in a Rat Model of Acute Retinal Ischemia/Reperfusion Injury. ( 27421045 )
2016
46
Pre-treatment with vinpocetine protects against retinal ischemia. ( 27899287 )
2016
47
Involvement of microRNA-181a and Bim in a rat model of retinal ischemia-reperfusion injury. ( 26949607 )
2016
48
Inhibiting Matrix Metalloproteinase 3 Ameliorates Neuronal Loss in the Ganglion Cell Layer of Rats in Retinal Ischemia/Reperfusion. ( 26830289 )
2016
49
Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. ( 26705611 )
2016
50
Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats. ( 27367588 )
2016

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 APAF1 BCL2 CASP2 CASP3 CAT HIF1A
2
Show member pathways
13.82 APAF1 BCL2 CASP3 CXCL12 HIF1A NFKB1
3
Show member pathways
13.38 BCL2 CASP3 CXCL12 HSPB1 NFKB1 TNF
4
Show member pathways
13.33 BCL2 CASP3 HIF1A NFKB1 TNF VEGFA
5
Show member pathways
13.27 BCL2 CASP2 CASP3 CXCL12 NFKB1 TNF
6
Show member pathways
13.11 CAT HIF1A NFKB1 SOD1 VEGFA
7
Show member pathways
12.97 BCL2 CASP3 NFKB1 TNF VEGFA
8
Show member pathways
12.9 APAF1 CASP2 CASP3 CXCL12 NFKB1 TNF
9
Show member pathways
12.9 APAF1 BCL2 CASP2 CASP3 NFKB1 TNF
10
Show member pathways
12.85 APAF1 CASP3 CXCL12 NFKB1 TNF VEGFA
11
Show member pathways
12.74 APAF1 BCL2 CASP3 CXCL12 HIF1A NFKB1
12 12.73 CASP2 CASP3 HSPB1 NFKB1 TNF VEGFA
13
Show member pathways
12.7 APAF1 BCL2 CASP2 CASP3 HSPB1
14
Show member pathways
12.69 APAF1 BCL2 CASP3 NFKB1
15
Show member pathways
12.68 APAF1 BCL2 CASP3 NFKB1 TNF
16 12.67 APAF1 BCL2 CASP3 CXCL12 HIF1A NFKB1
17
Show member pathways
12.64 APAF1 CASP3 NFKB1 VEGFA
18
Show member pathways
12.61 APAF1 BCL2 CASP2 CASP3 HSPB1 NFKB1
19
Show member pathways
12.58 BCL2 HIF1A NFKB1 TNF
20
Show member pathways
12.58 BCL2 CASP2 CASP3 NFKB1 TNF VEGFA
21
Show member pathways
12.57 HSPB1 NFKB1 TNF VEGFA
22 12.5 BCL2 CASP3 NFKB1 VEGFA
23
Show member pathways
12.48 APAF1 CASP2 CASP3 NFKB1 TNF
24
Show member pathways
12.34 CAT NFKB1 SOD1 TNF
25 12.3 CASP3 HIF1A TNF VEGFA
26
Show member pathways
12.26 CASP3 HIF1A NFKB1 VEGFA
27
Show member pathways
12.26 BCL2 CASP3 NFKB1 TNF
28 12.26 APAF1 BCL2 CASP3 NFKB1 TNF
29
Show member pathways
12.25 BCL2 CASP2 CASP3 HIF1A
30 12.2 APAF1 BCL2 CASP2 CASP3 TNF
31 12.18 CASP3 NFKB1 TNF VEGFA
32 12.16 APAF1 BCL2 CASP3 NFKB1 TNF
33 12.14 BCL2 CASP3 NFKB1 VEGFA
34
Show member pathways
12.12 APAF1 CASP3 NFKB1
35
Show member pathways
12.11 CAT NFKB1 SOD1
36 12.09 BCL2 NFKB1 TNF VEGFA
37 12.09 CASP3 HIF1A NFKB1 TNF VEGFA
38 12.08 BCL2 CASP2 CASP3
39
Show member pathways
12.07 APAF1 CASP2 CASP3 NFKB1 TNF
40 12.06 BCL2 HSPB1 NFKB1 VEGFA
41
Show member pathways
12.02 APAF1 BCL2 CASP3
42 11.99 BCL2 NFKB1 TNF
43 11.99 BCL2 HIF1A TNF VEGFA
44 11.98 BCL2 CAT NFKB1
45 11.96 CASP3 NFKB1 TNF
46 11.92 BCL2 HIF1A NFKB1 VEGFA
47
Show member pathways
11.92 BCL2 CASP2 CASP3 NFKB1 TNF
48 11.89 CASP3 HSPB1 NFKB1 TNF
49
Show member pathways
11.89 APAF1 BCL2 CASP2 CASP3 HSPB1 TNF
50 11.88 BCL2 CASP3 NFKB1

GO Terms for Retinal Ischemia

Cellular components related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CAT CXCL12 HSPB1 KNG1 SOD1 TNF
2 extracellular region GO:0005576 9.56 APAF1 CAT CXCL12 KNG1 NFKB1 SOD1
3 secretory granule lumen GO:0034774 9.43 APAF1 CAT NFKB1
4 axon cytoplasm GO:1904115 8.8 HIF1A HSPB1 SOD1

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.94 BCL2 CASP3 CAT SOD1
2 negative regulation of gene expression GO:0010629 9.91 HIF1A NFKB1 TNF VEGFA
3 positive regulation of angiogenesis GO:0045766 9.88 HIF1A HSPB1 VEGFA
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 CAT NFKB1 TNF
5 negative regulation of neuron apoptotic process GO:0043524 9.86 BCL2 HIF1A SOD1
6 response to oxidative stress GO:0006979 9.85 BCL2 CAT SOD1
7 cellular response to hypoxia GO:0071456 9.84 BCL2 HIF1A VEGFA
8 platelet degranulation GO:0002576 9.84 KNG1 SOD1 VEGFA
9 response to virus GO:0009615 9.83 CXCL12 HSPB1 TNF
10 response to organic substance GO:0010033 9.81 CASP3 SOD1 TNF
11 aging GO:0007568 9.81 APAF1 CASP2 CAT SOD1
12 positive regulation of catalytic activity GO:0043085 9.8 BCL2 CASP3 SOD1
13 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 APAF1 CASP3 TNF
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 BCL2 TNF VEGFA
15 positive regulation of endothelial cell proliferation GO:0001938 9.77 CXCL12 HIF1A VEGFA
16 cytokine-mediated signaling pathway GO:0019221 9.77 BCL2 CASP3 HIF1A TNF VEGFA
17 response to glucocorticoid GO:0051384 9.76 BCL2 CASP3 TNF
18 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.73 BCL2 CASP2 TNF
19 positive regulation of cell adhesion GO:0045785 9.72 CXCL12 TNF VEGFA
20 execution phase of apoptosis GO:0097194 9.71 CASP2 CASP3
21 B cell homeostasis GO:0001782 9.71 BCL2 CASP3
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.71 HIF1A HSPB1 VEGFA
23 kidney development GO:0001822 9.71 APAF1 BCL2 CAT VEGFA
24 camera-type eye morphogenesis GO:0048593 9.7 HIF1A VEGFA
25 dopaminergic neuron differentiation GO:0071542 9.7 HIF1A VEGFA
26 positive regulation of neuroblast proliferation GO:0002052 9.7 HIF1A VEGFA
27 negative regulation of ossification GO:0030279 9.69 BCL2 HIF1A
28 negative regulation of reactive oxygen species metabolic process GO:2000378 9.69 BCL2 HIF1A
29 muscle cell cellular homeostasis GO:0046716 9.68 HIF1A SOD1
30 positive regulation of chemokine production GO:0032722 9.68 HIF1A TNF
31 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 HIF1A VEGFA
32 response to iron ion GO:0010039 9.67 BCL2 HIF1A
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 HSPB1 TNF
34 ovarian follicle development GO:0001541 9.67 BCL2 SOD1 VEGFA
35 digestive tract morphogenesis GO:0048546 9.66 BCL2 HIF1A
36 induction of positive chemotaxis GO:0050930 9.65 CXCL12 VEGFA
37 neuron apoptotic process GO:0051402 9.65 APAF1 BCL2 CASP3
38 response to reactive oxygen species GO:0000302 9.64 CAT SOD1
39 response to radiation GO:0009314 9.63 BCL2 CAT CXCL12
40 positive regulation of apoptotic process GO:0043065 9.63 APAF1 CASP2 CASP3 KNG1 SOD1 TNF
41 apoptotic signaling pathway GO:0097190 9.62 APAF1 CASP2 CASP3 TNF
42 cellular response to nicotine GO:0071316 9.61 NFKB1 TNF
43 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.61 BCL2 CASP2 CASP3
44 positive regulation of axon extension involved in axon guidance GO:0048842 9.59 CXCL12 VEGFA
45 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.58 HSPB1 VEGFA
46 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.57 HIF1A VEGFA
47 response to hydrogen peroxide GO:0042542 9.56 BCL2 CASP3 CAT SOD1
48 luteolysis GO:0001554 9.52 CASP2 CASP3
49 response to hypoxia GO:0001666 9.43 APAF1 CASP3 CAT CXCL12 HIF1A VEGFA
50 negative regulation of apoptotic process GO:0043066 9.28 BCL2 CASP2 CASP3 CAT HIF1A HSPB1

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 CASP2 CAT HIF1A SOD1
2 protein homodimerization activity GO:0042803 9.63 BCL2 CAT HSPB1 NFKB1 SOD1 VEGFA
3 protease binding GO:0002020 9.43 BCL2 CASP3 TNF
4 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 9.4 APAF1 CASP3
5 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.37 CASP2 CASP3
6 identical protein binding GO:0042802 9.28 APAF1 BCL2 CASP2 CAT HSPB1 NFKB1
7 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.96 CASP2 CASP3
8 protein binding GO:0005515 10.13 APAF1 BCL2 CASP2 CASP3 CXCL12 HIF1A

Sources for Retinal Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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