MCID: RTN003
MIFTS: 48

Retinal Ischemia

Categories: Cardiovascular diseases, Eye diseases, Neuronal diseases
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Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 11 53 14 36 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:12510
ICD9CM 34 362.84
SNOMED-CT 68 193427006
UMLS 71 C0162291

Summaries for Retinal Ischemia

Disease Ontology: 11 An ischemia that is characterized by restriction in blood supply to the retina.

MalaCards based summary: Retinal Ischemia is related to microvascular complications of diabetes 5 and central retinal artery occlusion. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include retina, bone marrow and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 633)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 31.2 VEGFA ICAM1 HIF1A CRYAA
2 central retinal artery occlusion 31.0 VEGFA POU4F1 CRYAA
3 ischemia 31.0 VEGFA TNF IL6 ICAM1 HSPB1 HMOX1
4 exudative vitreoretinopathy 1 30.8 VEGFA TNF IL6 IL1B ICAM1 HIF1A
5 retinal vein occlusion 30.8 VEGFA TNF IL6 IL1B
6 retinal artery occlusion 30.8 VEGFA IL6 ICAM1 HMOX1 CRYAA
7 neovascular glaucoma 30.7 VEGFA IL6 CRYAA
8 microvascular complications of diabetes 1 30.7 VEGFA ICAM1 HIF1A
9 carotid stenosis 30.6 VEGFA TNF ICAM1
10 ocular hypertension 30.6 TXN POU4F1 CRYAA
11 macular retinal edema 30.5 VEGFA TNF IL6 IL1B ICAM1
12 central retinal vein occlusion 30.5 VEGFA IL6 ICAM1
13 retinal vascular occlusion 30.3 VEGFA TNF IL6 ICAM1 HIF1A CRYAA
14 retinal vascular disease 30.3 VEGFA TXN TNF IL6 IL1B ICAM1
15 vasculitis 30.3 TNF IL6 IL1B ICAM1
16 cerebrovascular disease 30.3 TNF IL6 IL1B CASP3 BDNF
17 nonarteritic anterior ischemic optic neuropathy 30.2 VEGFA POU4F1 CNTF AIF1
18 carotid artery occlusion 30.2 VEGFA IL1B CASP3 BDNF BCL2 AIF1
19 acute closed-angle glaucoma 30.2 VEGFA RBPMS POU4F1
20 henoch-schoenlein purpura 30.2 TNF IL6 ICAM1
21 vascular disease 30.2 VEGFA TNF IL6 ICAM1 HMOX1 CASP3
22 intraocular pressure quantitative trait locus 30.2 VEGFA RBPMS POU4F1 HSPB1 CRYAA CNTF
23 macular holes 30.1 VEGFA IL6 CRYAA
24 rubeosis iridis 30.1 VEGFA IL6
25 melanoma, uveal 30.1 VEGFA HIF1A CRYAA BCL2
26 retinal detachment 30.0 VEGFA TNF IL6 ICAM1 BCL2
27 conjunctivitis 30.0 TNF IL6 ICAM1
28 allergic conjunctivitis 30.0 TNF IL6 IL1B
29 temporal arteritis 30.0 VEGFA TNF IL6 IL1B ICAM1
30 anterior uveitis 29.9 VEGFA TNF IL6 IL1B
31 central nervous system disease 29.9 HMOX1 CRYAA CNTF BDNF
32 uveitis 29.9 VEGFA TNF IL6 IL1B ICAM1 CRYAA
33 leptin deficiency or dysfunction 29.8 TNF IL6 IL1B BDNF
34 sarcoidosis 1 29.8 TNF IL6 IL1B ICAM1
35 sickle cell anemia 29.8 TNF IL6 ICAM1 HMOX1
36 hyperglycemia 29.8 TXN TNF IL6 HIF1A BDNF
37 leukostasis 29.8 VEGFA TNF IL6 IL1B ICAM1
38 stroke, ischemic 29.8 VEGFA TNF IL6 IL1B CNTF CASP3
39 behcet syndrome 29.8 VEGFA TNF IL6 IL1B ICAM1
40 respiratory failure 29.7 VEGFA TNF IL6 IL1B ICAM1
41 optic nerve disease 29.7 VEGFA TNF RBPMS POU4F1 IL6 IL1B
42 fundus dystrophy 29.7 VEGFA POU4F1 CRYAA CNTF BDNF AIF1
43 endophthalmitis 29.7 VEGFA TNF IL6 IL1B ICAM1 CRYAA
44 cardiovascular system disease 29.6 TNF IL6 ICAM1 HMOX1 BDNF
45 glaucoma, primary open angle 29.6 VEGFA TNF RBPMS POU4F1 CRYAA CNTF
46 myeloma, multiple 29.6 VEGFA IL6 IL1B ICAM1 CASP3 BDNF
47 toxic encephalopathy 29.5 TNF IL6 IL1B HMOX1 CASP3 BDNF
48 cataract 29.4 VEGFA TXN TNF IL6 ICAM1 HSPB1
49 neuroblastoma 29.2 VEGFA TNF IL6 IL1B HMOX1 HIF1A
50 macular degeneration, age-related, 1 29.2 VEGFA TNF POU4F1 IL6 IL1B ICAM1

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 AIF1 BCL2 BDNF CASP3 CNTF CRYAA
2 no effect GR00402-S-2 10.18 AIF1 BCL2 BDNF CASP3 HIF1A HMOX1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.1 CASP3 HIF1A IL1B TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.1 CASP3 HIF1A HMOX1 ICAM1 IL1B PCNA
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.1 HIF1A ICAM1 PCNA

MGI Mouse Phenotypes related to Retinal Ischemia:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 AIF1 BCL2 BDNF CASP3 CNTF HIF1A
2 nervous system MP:0003631 10.35 AIF1 BCL2 BDNF CASP3 CNTF HIF1A
3 growth/size/body region MP:0005378 10.34 AIF1 BCL2 BDNF CASP3 HIF1A HMOX1
4 cellular MP:0005384 10.25 BCL2 BDNF CASP3 CNTF CRYAA HIF1A
5 muscle MP:0005369 10.22 BCL2 CASP3 CNTF HIF1A HMOX1 ICAM1
6 endocrine/exocrine gland MP:0005379 10.22 BCL2 BDNF CASP3 CNTF HIF1A HMOX1
7 cardiovascular system MP:0005385 10.21 AIF1 BCL2 CASP3 HIF1A HMOX1 HSPB1
8 immune system MP:0005387 10.2 AIF1 BCL2 CASP3 CNTF HIF1A HMOX1
9 neoplasm MP:0002006 10.16 BCL2 HIF1A ICAM1 IL1B IL6 SETD2
10 no phenotypic analysis MP:0003012 10.15 BDNF CASP3 CNTF HSPB1 PCNA POU4F1
11 craniofacial MP:0005382 10.09 BCL2 BDNF CASP3 HIF1A HMOX1 IL1B
12 digestive/alimentary MP:0005381 10.06 BCL2 BDNF CASP3 HIF1A ICAM1 IL6
13 vision/eye MP:0005391 9.93 AIF1 BCL2 BDNF CASP3 CRYAA HIF1A
14 respiratory system MP:0005388 9.86 BDNF CASP3 HIF1A HMOX1 IL6 RBPMS
15 hematopoietic system MP:0005397 9.83 AIF1 BCL2 CASP3 CNTF HIF1A HMOX1
16 mortality/aging MP:0010768 9.5 BCL2 BDNF CASP3 HIF1A HMOX1 ICAM1

Drugs & Therapeutics for Retinal Ischemia

Drugs for Retinal Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
3 Antineoplastic Agents, Hormonal Phase 4
4 Hormones Phase 4
5 Hormone Antagonists Phase 4
6 Antiemetics Phase 4
7 glucocorticoids Phase 4
8 BB 1101 Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Gastrointestinal Agents Phase 4
11
Ranibizumab Approved Phase 1, Phase 2 347396-82-1
12 Angiogenesis Inhibitors Phase 1, Phase 2
13
Aflibercept Approved 862111-32-8 124490314
14 Endothelial Growth Factors
15 Mitogens

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME (RMSM ICOD STUDY) Unknown status NCT04038125 Phase 4 Ozurdex Drug Implant Product
2 Normobaric Nocturnal Hyperoxia Therapy for Treating Ischemic-Related Retinal Conditions Withdrawn NCT03730779 Phase 4 Hyperoxia
3 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
4 Evaluation of Microvascular Changes in the Perifoveal Vascular Network Using Optical Coherence Tomography Angiography (OCT-A) in Type I Diabetes Mellitus Unknown status NCT03422965
5 Objective Measurement of Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With a Vascular Endothelial Growth Factor Inhibitor. Completed NCT01360385
6 Developing a Non-invasive Method and Device for Assessing the Degree of Midperipheral Retinal Ischemia in Diabetic Retinopathy. Completed NCT01546766
7 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes Completed NCT03906383
8 Retinal Ischemia Characterization in Diabetes. Recruiting NCT05112445
9 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
10 Ultra-wide Fluorescein angiograpHy to Evaluate the Progression of Retinal ischeMia After aflibErcept Injections in patientS With Central Retinal Vein Occlusion in Real Life (HERMES Study) Active, not recruiting NCT02880644
11 Prediction of Progression of Retinal Ischemia in Diabetes Not yet recruiting NCT05581225

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 21225138 23000646 19347139 23049424

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

Organs/tissues related to Retinal Ischemia:

MalaCards : Retina, Bone Marrow, Endothelial, Brain, Bone, Eye, Myeloid

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 1795)
# Title Authors PMID Year
1
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. 53 62
20008515 2010
2
Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion. 53 62
19967679 2010
3
Insulin may cause deterioration of proliferative diabetic retinopathy. 53 62
19027244 2009
4
[Effects of recombinant human erythropoietin on hypoxia inducible factor-1alpha expression in the retina of rabbits with acute high intraocular pressure]. 53 62
19246297 2009
5
Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. 53 62
19118700 2009
6
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. 53 62
17591953 2007
7
Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats. 53 62
15728570 2005
8
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 53 62
14633857 2003
9
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. 53 62
11328942 2001
10
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. 53 62
11110038 2000
11
VEGF increases retinal vascular ICAM-1 expression in vivo. 53 62
10393052 1999
12
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. 53 62
9499769 1998
13
Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. 53 62
9285495 1997
14
Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease. 53 62
9046048 1997
15
Analysis of localization of adult T-cell leukemia-derived factor in the transient ischemic rat retina after treatment with OP-1206 alpha-CD, a prostaglandin E1 analogue. 53 62
9010470 1997
16
Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. 53 62
8942877 1996
17
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. 53 62
7479819 1995
18
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. 53 62
7540233 1995
19
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. 53 62
8529097 1995
20
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. 53 62
8206709 1994
21
Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. 53 62
7504689 1993
22
Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy. 62
36254977 2023
23
Permanent damage of the inner retinal layers in a patient with migraine: a different case of paracentral acute middle maculopathy. 62
36309339 2022
24
Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury. 62
35662225 2022
25
Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury. 62
36471420 2022
26
Resveratrol dilates arterioles and protects against N-methyl-D-aspartic acid-induced excitotoxicity in the rat retina. 62
36470506 2022
27
Retinal ischemic cascade: New insights into the pathophysiology and imaging findings. 62
36464134 2022
28
Purtscher-like retinopathy in a patient with systemic tacrolimus vasculopathy. 62
36451542 2022
29
Activation of HIF-1α/VEGF-A pathway by deferoxamine ameliorates retinal hypoxia in a rat subarachnoid hemorrhage model. 62
36165027 2022
30
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury. 62
36152538 2022
31
Redefining the Koizumi model of mouse cerebral ischemia: A comparative longitudinal study of cerebral and retinal ischemia in the Koizumi and Longa middle cerebral artery occlusion models. 62
35748043 2022
32
Pregabalin Mediates Retinal Ganglion Cell Survival From Retinal Ischemia/Reperfusion Injury Via the Akt/GSK3β/β-Catenin Signaling Pathway. 62
36326725 2022
33
[Ischemia and laser photocoagulation in retinal vein occlusion]. 62
36357589 2022
34
Incontinentia pigmenti and the eye. 62
35819905 2022
35
Neovascular Glaucoma: An Update. 62
36436509 2022
36
Risk factors for ischemic cerebral stroke in patients with acute amaurosis fugax. 62
36368408 2022
37
Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases. 62
36432666 2022
38
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma. 62
36361772 2022
39
Intra-arterial Thrombolysis for Acute Retinal Ischemia: A Retrospective, Observational, Cohort Study. 62
36255085 2022
40
Mitochondrial Dysfunction in a High Intraocular Pressure-Induced Retinal Ischemia Minipig Model. 62
36291741 2022
41
A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion. 62
36330401 2022
42
Regulatory effect of long-stranded non-coding RNA-CRNDE on neurodegeneration during retinal ischemia-reperfusion. 62
36276743 2022
43
Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia. 62
36220097 2022
44
Withaferin a Attenuates Retinal Ischemia-Reperfusion Injury via Akt-Dependent Inhibition of Oxidative Stress. 62
36231074 2022
45
Correction to: Eye Opener in Stroke: Mitochondrial Dysfunction and Stem Cell Repair in Retinal Ischemia. 62
36154134 2022
46
Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury. 62
36289494 2022
47
Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms. 62
36031679 2022
48
RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study. 62
35976232 2022
49
Purtscher-Like Retinopathy with Cardioembolic Stroke: Case Report and Literature Review. 62
36466061 2022
50
Retinal degeneration induced in a mouse model of ischemia-reperfusion injury and its management by pemafibrate treatment. 62
35969144 2022

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 BCL2 CASP3 CNTF HIF1A HMOX1 ICAM1
2
Show member pathways
13.64 VEGFA TNF IL6 IL1B CNTF CASP3
3
Show member pathways
13.54 VEGFA TNF IL6 IL1B ICAM1 HSPB1
4
Show member pathways
13.41 TNF IL6 IL1B HSPB1 CASP3 BDNF
5
Show member pathways
13.21 VEGFA TNF IL6 IL1B ICAM1 HMOX1
6
Show member pathways
12.84 BCL2 CASP3 IL1B IL6 PCNA TNF
7 12.65 BCL2 BDNF HIF1A IL1B IL6 SETD2
8
Show member pathways
12.63 TNF IL1B CASP3 BDNF BCL2
9 12.39 TNF IL1B HSPB1 CASP3 BDNF
10
Show member pathways
12.37 TNF HSPB1 CASP3 BCL2
11
Show member pathways
12.36 TXN TNF CASP3 BCL2
12
Show member pathways
12.35 TNF HSPB1 CASP3 BCL2
13 12.19 VEGFA TNF IL6 CASP3
14 12.08 VEGFA HSPB1 HIF1A BCL2
15 12 VEGFA TNF IL6 IL1B HIF1A CASP3
16 11.94 BCL2 BDNF CNTF IL1B IL6 TNF
17 11.93 PCNA IL6 IL1B BCL2
18
Show member pathways
11.93 TXN IL1B HMOX1 BCL2
19 11.86 VEGFA TNF IL1B CASP3
20 11.83 VEGFA SETD2 HIF1A
21 11.79 VEGFA CNTF BDNF
22
Show member pathways
11.78 IL6 HIF1A CASP3
23 11.76 IL1B IL6 TNF
24 11.76 TNF IL6 IL1B ICAM1 CASP3 BDNF
25 11.75 IL6 CASP3 BCL2 AIF1
26
Show member pathways
11.74 VEGFA IL6 CNTF
27 11.72 IL6 IL1B HIF1A
28 11.69 VEGFA HMOX1 HIF1A
29 11.67 IL1B IL6 TNF
30 11.66 ICAM1 IL6 TNF
31 11.66 TNF IL6 IL1B HMOX1
32 11.6 VEGFA IL6 BDNF
33 11.59 VEGFA IL6 HIF1A CASP3
34 11.58 TNF ICAM1 CASP3
35
Show member pathways
11.57 VEGFA TNF IL6 IL1B ICAM1
36 11.56 TNF HSPB1 CASP3
37 11.53 VEGFA IL6 CNTF
38 11.51 TNF IL6 IL1B ICAM1
39 11.5 TNF IL6 IL1B
40 11.43 TNF PCNA CASP3 BCL2
41 11.41 VEGFA IGFBP2 HIF1A
42 11.39 TNF CASP3 BCL2
43 11.37 VEGFA TNF IL6 IL1B ICAM1 CASP3
44 11.36 VEGFA SETD2 HIF1A
45 11.36 TNF IL6 IL1B HMOX1
46 11.33 TNF IL6 IL1B
47 11.32 TNF CASP3 BCL2
48 11.27 TNF IL6 IL1B
49 11.27 TNF IL6 ICAM1
50 11.26 TNF IL6 IL1B HMOX1

GO Terms for Retinal Ischemia

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.41 CNTF HIF1A IL1B IL6 POU4F1 TNF
2 response to xenobiotic stimulus GO:0009410 10.35 TNF IGFBP2 HMOX1 CASP3 BCL2
3 cellular response to hypoxia GO:0071456 10.26 BCL2 HIF1A HMOX1 VEGFA
4 positive regulation of interleukin-6 production GO:0032755 10.22 TNF IL6 IL1B AIF1
5 response to hypoxia GO:0001666 10.21 VEGFA TNF HMOX1 HIF1A CASP3
6 positive regulation of angiogenesis GO:0045766 10.21 HIF1A HMOX1 HSPB1 IL1B VEGFA
7 negative regulation of apoptotic process GO:0043066 10.19 AIF1 BCL2 CASP3 CRYAA HIF1A HSPB1
8 neuron apoptotic process GO:0051402 10.18 POU4F1 HIF1A CASP3 BCL2
9 response to hydrogen peroxide GO:0042542 10.16 HMOX1 CASP3 BCL2
10 positive regulation of blood vessel endothelial cell migration GO:0043536 10.16 VEGFA HSPB1 HIF1A
11 positive regulation of nitric oxide biosynthetic process GO:0045429 10.15 TNF IL1B AIF1
12 response to oxidative stress GO:0006979 10.14 RBPMS PCNA HMOX1 BCL2
13 response to nicotine GO:0035094 10.13 HMOX1 CASP3 BCL2
14 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.12 TNF IL1B BCL2
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 10.12 HSPB1 IL1B TNF
16 response to radiation GO:0009314 10.11 TXN TNF BCL2
17 negative regulation of neuron apoptotic process GO:0043524 10.11 POU4F1 HMOX1 HIF1A CNTF BDNF BCL2
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 10.1 VEGFA TXN TNF IL6 BDNF BCL2
19 positive regulation of vascular endothelial growth factor production GO:0010575 10.09 IL6 IL1B HIF1A
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.08 VEGFA TNF IL6 CNTF
21 positive regulation of smooth muscle cell proliferation GO:0048661 10.08 TNF IL6 HMOX1 AIF1
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.07 TNF IL6 HIF1A
23 negative regulation of neurogenesis GO:0050768 10.06 TNF IL6 IL1B
24 positive regulation of glial cell proliferation GO:0060252 10.02 TNF IL6 IL1B
25 liver regeneration GO:0097421 10.01 HMOX1 IL6 PCNA TNF
26 cellular response to organic substance GO:0071310 10 IL1B CASP3 BCL2
27 epithelial cell apoptotic process GO:1904019 10 HMOX1 CASP3 BCL2
28 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.99 HMOX1 HIF1A
29 positive regulation of mononuclear cell migration GO:0071677 9.98 TNF AIF1
30 negative regulation of apoptotic signaling pathway GO:2001234 9.98 TNF HSPB1 BDNF BCL2
31 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.97 VEGFA HIF1A
32 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.97 VEGFA HSPB1
33 positive regulation of fever generation GO:0031622 9.97 TNF IL1B
34 astrocyte activation GO:0048143 9.97 TNF IL1B CNTF
35 sequestering of triglyceride GO:0030730 9.94 TNF IL1B
36 leukocyte migration GO:0050900 9.93 TNF IL1B ICAM1
37 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.91 TNF IL1B
39 response to organic cyclic compound GO:0014070 9.91 BCL2 CASP3 IGFBP2 TNF
40 vascular endothelial growth factor production GO:0010573 9.76 TNF IL6 IL1B HIF1A
41 response to glucocorticoid GO:0051384 9.73 TNF IL6 IGFBP2 CASP3 BCL2 AIF1
42 positive regulation of chemokine production GO:0032722 9.36 TNF IL6 IL1B HMOX1 HIF1A AIF1

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 VEGFA TNF IL6 IL1B CNTF

Sources for Retinal Ischemia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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