Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 38 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12510
ICD10 33 H35.82
ICD9CM 35 362.84
SNOMED-CT 68 193427006 26468004
UMLS 73 C0162291

Summaries for Retinal Ischemia

MalaCards based summary : Retinal Ischemia is related to ischemia and eales disease. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Bevacizumab and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and retina, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 ischemia 29.4 CASP3 CXCL12 HIF1A KNG1 SOD1 VEGFA
2 eales disease 29.3 SOD1 TNF VEGFA
3 aging 29.3 HIF1A NFKB1 SOD1
4 exudative vitreoretinopathy 1 10.9
5 exudative vitreoretinopathy 2, x-linked 10.9
6 exudative vitreoretinopathy 4 10.9
7 exudative vitreoretinopathy 3 10.9
8 retinitis 10.9
9 age-related hearing loss 10.6 HIF1A SETD2
10 cerebral artery occlusion 10.5 HIF1A TNF
11 meningitis and encephalitis 10.4 CAT SOD1
12 intravascular papillary endothelial hyperplasia 10.4 HIF1A VEGFA
13 aids dementia complex 10.4 CXCL12 TNF
14 dystrophinopathies 10.3 CASP2 TNF
15 acute vascular insufficiency of intestine 10.2 SOD1 TNF
16 crimean-congo hemorrhagic fever 10.2 CASP3 NFKB1 TNF
17 critical limb ischemia 10.2 HIF1A TNF VEGFA
18 neuronitis 10.2
19 kashin-beck disease 10.2 BAX TNF
20 erysipelas 10.2 CAT SOD1 TNF
21 helicobacter pylori infection 10.1 CASP3 NFKB1 TNF
22 endotheliitis 10.1
23 central nervous system disease 10.1 CASP3 SOD1 TNF
24 pneumoconiosis 10.1 CAT SOD1 TNF
25 retinal hemangioblastoma 10.1 CXCL12 HIF1A VEGFA
26 gastrointestinal system cancer 10.0 CASP3 TNF VEGFA
27 microvascular complications of diabetes 5 10.0
28 clear cell renal cell carcinoma 10.0 HIF1A SETD2 VEGFA
29 radiation proctitis 10.0 TNF VEGFA
30 retinal vein occlusion 10.0
31 kaposi sarcoma 9.9 HIF1A TNF VEGFA
32 choroiditis 9.9
33 huntington disease 9.9 CASP2 CASP3 SETD2 SOD1
34 neurofibromatosis, type i 9.8
35 neurofibromatosis, type iv, of riccardi 9.8
36 central retinal artery occlusion 9.8
37 retinal artery occlusion 9.8
38 poems syndrome 9.8 TNF VEGFA
39 limb ischemia 9.8 CXCL12 HIF1A TNF VEGFA
40 temporal arteritis 9.8
41 cataract 9.8
42 neovascular glaucoma 9.8
43 cerebritis 9.8
44 macular retinal edema 9.8
45 ocular hypertension 9.8
46 hypoxia 9.8
47 arteries, anomalies of 9.8 KNG1 TNF VEGFA
48 myeloma, multiple 9.7 CASP3 CXCL12 TNF VEGFA
49 nasopharyngeal carcinoma 9.7 CASP3 CXCL12 HIF1A VEGFA
50 brain edema 9.7 KNG1 SOD1 VEGFA

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.9 VEGFA PCNA CASP2 SETD2
2 Increased Nanog expression GR00371-A-2 9.9 VEGFA SETD2
3 Increased Nanog expression GR00371-A-4 9.9 VEGFA SETD2
4 Increased Nanog expression GR00371-A-5 9.9 VEGFA CASP2 SETD2
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 HIF1A TNF NFKB1 BAX PCNA CASP3
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 HIF1A TNF NFKB1 BAX PCNA CASP3
7 Increased cell death HMECs cells GR00103-A-0 9.72 HIF1A PCNA CASP2 CASP3 CAT
8 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.65 PCNA CASP2 CASP3 CAT TNF
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 HIF1A NFKB1 BAX PCNA SOD1

MGI Mouse Phenotypes related to Retinal Ischemia:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 TNF VEGFA CASP3 HIF1A HSPB1 BAX
2 hematopoietic system MP:0005397 10.3 TNF VEGFA CASP3 HIF1A SETD2 HSPB1
3 growth/size/body region MP:0005378 10.28 VEGFA TNF SOD1 PCNA CASP3 HSPB1
4 immune system MP:0005387 10.27 TNF VEGFA PCNA CASP3 HIF1A SETD2
5 mortality/aging MP:0010768 10.23 TNF VEGFA PCNA CASP3 HIF1A SETD2
6 homeostasis/metabolism MP:0005376 10.21 SOD1 VEGFA TNF HIF1A HSPB1 CASP3
7 endocrine/exocrine gland MP:0005379 10.2 VEGFA TNF SOD1 CASP2 PCNA CASP3
8 cardiovascular system MP:0005385 10.18 SOD1 VEGFA TNF CXCL12 HIF1A HSPB1
9 nervous system MP:0003631 10.07 VEGFA TNF SOD1 CASP2 CASP3 SETD2
10 craniofacial MP:0005382 10.03 VEGFA TNF HIF1A CASP3 SETD2 NFKB1
11 muscle MP:0005369 10.03 TNF VEGFA CASP3 HIF1A BAX NFKB1
12 liver/biliary system MP:0005370 9.95 SOD1 VEGFA TNF CXCL12 HIF1A NFKB1
13 neoplasm MP:0002006 9.95 TNF VEGFA SETD2 BAX CAT SOD1
14 reproductive system MP:0005389 9.86 VEGFA TNF SOD1 CXCL12 CASP2 PCNA
15 no phenotypic analysis MP:0003012 9.8 VEGFA TNF CXCL12 PCNA HSPB1 CASP3
16 respiratory system MP:0005388 9.63 VEGFA TNF HIF1A CASP3 BAX NFKB1
17 skeleton MP:0005390 9.56 VEGFA TNF SOD1 HIF1A CASP3 SETD2
18 vision/eye MP:0005391 9.17 SOD1 VEGFA TNF HIF1A CASP3 SETD2

Drugs & Therapeutics for Retinal Ischemia

Drugs for Retinal Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Warfarin Approved Phase 4 81-81-2 6691 54678486
3
Ranibizumab Approved Phase 4,Phase 1,Phase 2 347396-82-1 459903
4
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
5 Antibodies Phase 4,Phase 3
6 Immunoglobulins Phase 4,Phase 3
7 Angiogenesis Inhibitors Phase 4,Phase 1,Phase 2
8 Angiogenesis Modulating Agents Phase 4,Phase 1,Phase 2
9 Anticoagulants Phase 4
10 Antithrombin III Phase 4
11 Antithrombins Phase 4
12 Dabigatran Phase 4
13 HIV Protease Inhibitors Phase 4
14
protease inhibitors Phase 4
15 Serine Proteinase Inhibitors Phase 4
16
Aspirin Approved, Vet_approved Phase 3,Not Applicable 50-78-2 2244
17
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
18 Antibodies, Monoclonal Phase 3
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
20 Neurotransmitter Agents Phase 3
21 Platelet Aggregation Inhibitors Phase 3,Not Applicable
22 Purinergic P2 Receptor Antagonists Phase 3
23 Purinergic P2Y Receptor Antagonists Phase 3
24
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
25
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
26 Antiemetics Phase 1, Phase 2
27 Anti-Inflammatory Agents Phase 1, Phase 2,Not Applicable
28 Autonomic Agents Phase 1, Phase 2
29 Epoetin alfa Phase 1, Phase 2 113427-24-0
30 Gastrointestinal Agents Phase 1, Phase 2
31 glucocorticoids Phase 1, Phase 2
32 Hematinics Phase 1, Phase 2
33 Hormone Antagonists Phase 1, Phase 2
34 Hormones Phase 1, Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
36 Methylprednisolone acetate Phase 1, Phase 2
37 Methylprednisolone Hemisuccinate Phase 1, Phase 2
38 Neuroprotective Agents Phase 1, Phase 2
39 Peripheral Nervous System Agents Phase 1, Phase 2,Not Applicable
40 Prednisolone acetate Phase 1, Phase 2
41 Prednisolone hemisuccinate Phase 1, Phase 2
42 Prednisolone phosphate Phase 1, Phase 2
43 Protective Agents Phase 1, Phase 2
44 Endothelial Growth Factors Phase 1, Phase 2
45 Mitogens Phase 1, Phase 2
46 Analgesics Not Applicable
47 Analgesics, Non-Narcotic Not Applicable
48 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
49 Antipyretics Not Applicable
50 Antirheumatic Agents Not Applicable

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) Unknown status NCT02432547 Phase 4 Aflibercept
2 Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
3 Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT) Completed NCT02348723 Phase 4 Warfarin;Dabigatran Etexilate 150mg
4 Long-Term Efficacy & Safety of Aflibercept IVT for the Treatment of DME in Subjects Who Completed the VISTA-DME Trial Completed NCT02299336 Phase 4 Aflibercept
5 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
6 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA Recruiting NCT03246152 Phase 4 Bevacizumab
7 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion Not yet recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
8 Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Completed NCT01764633 Phase 3 Placebo
9 Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Active, not recruiting NCT00991029 Phase 3 Clopidogrel;placebo
10 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
11 Traumatic Optic Neuropathy Treatment Trial (TONTT) Completed NCT01783847 Phase 1, Phase 2 Recombinant human erythropoietin (EPO)
12 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Recruiting NCT02957760 Phase 2 Hydroxycarbamid
13 Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy. Recruiting NCT02151695 Phase 2 Aflibercept intravitreal injections
14 Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy. Active, not recruiting NCT02222610 Phase 2 0.5 mg ranibizumab
15 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
16 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
17 Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab Completed NCT01360385
18 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
19 Ultra-wide Fluorescein Angiography in Patients With Central Retinal Vein Occlusion Treated by Afilbercept Recruiting NCT02880644
20 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Recruiting NCT03061526
21 Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device) Recruiting NCT01546766
22 Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes Recruiting NCT02876744
23 Detecting the Influence of Cataract Surgery on the Development of Diabetic Retinopathy in Patients With Diabetes Mellitus Type 2 With and Without Diabetic Retinopathy Using OCT Angiography Recruiting NCT03571139
24 Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus Recruiting NCT03422965 Not Applicable
25 Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module Recruiting NCT03530449
26 Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV) Recruiting NCT03525132 Not Applicable
27 Pediatric Type 1 Diabetes and Retinopathy Active, not recruiting NCT02691312
28 Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation Not yet recruiting NCT03232450 Not Applicable Aspirin
29 Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial Terminated NCT00379223 Not Applicable

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 23049424 21225138 19347139 23000646

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

MalaCards organs/tissues related to Retinal Ischemia:

41
Endothelial, Bone, Retina, Eye, Brain, Bone Marrow, Myeloid

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 325)
# Title Authors Year
1
Carotid ergotism with retinal ischemia. ( 29708216 )
2018
2
Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion. ( 29942024 )
2018
3
PROGRESSION OF RETINAL ISCHEMIA IN A CASE OF MACULAR TELANGIECTASIA TYPE 1 AFTER RANIBIZUMAB INJECTION: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS. ( 29443804 )
2018
4
Low-dose minocycline mediated neuroprotection on retinal ischemia-reperfusion injury of mice. ( 29853771 )
2018
5
A Model for Graded Retinal Ischemia in Rats. ( 29881647 )
2018
6
Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits. ( 29323543 )
2018
7
The effects of bevacizumab treatment in a rat model of retinal ischemia and perfusion injury. ( 29681725 )
2018
8
Fewer Functional Deficits and Reduced Cell Death after Ranibizumab Treatment in a Retinal Ischemia Model. ( 29857531 )
2018
9
Management of Acute Retinal Ischemia: Follow the Guidelines! ( 29716787 )
2018
10
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. ( 29552298 )
2018
11
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. ( 29111459 )
2018
12
Ocular Blood Flow in Rabbits under Deep Anesthesia: A Real-Time Measurement Technique and Its Application in Characterizing Retinal Ischemia. ( 29632320 )
2018
13
Use of OCTA, FA, and Ultra-Widefield Imaging in Quantifying Retinal Ischemia: A Review. ( 29436208 )
2018
14
Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia. ( 29106899 )
2018
15
Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia. ( 28823941 )
2017
16
Application of Arterial Spin Labelling in Detecting Retinal Ischemia. ( 29422857 )
2017
17
Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. ( 29296071 )
2017
18
Dexmedetomidine preconditioning protects against retinal ischemia/reperfusion injury and inhibits inflammation response via toll-like receptor 4 (TLR4) pathway. ( 28724211 )
2017
19
Pioglitazone ameliorates retinal ischemia/reperfusion injury<i>via</i>suppressing NLRP3 inflammasome activities. ( 29259897 )
2017
20
Resveratrol Ameliorates Retinal Ischemia/Reperfusion Injury in C57BL/6J Mice via Downregulation of Caspase-3. ( 28985092 )
2017
21
Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1I+ and VEGF via inhibition of RBP2 and PKM2. ( 28709426 )
2017
22
Letter by Kawada Regarding Article, &amp;quot;Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study&amp;quot;. ( 28626051 )
2017
23
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
24
OCT Angiography: Assessment of Retinal Ischemia in Susac's Syndrome. ( 28613358 )
2017
25
Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice. ( 28210901 )
2017
26
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. ( 28386036 )
2017
27
Curcumin protects against hypertension aggravated retinal ischemia/reperfusion in a rat stroke model. ( 28678631 )
2017
28
Neuroprotective effects of a novel peptide, FK18, under oxygen-glucose deprivation in SH-SY5Y cells and retinal ischemia in ratsA viaA the Akt pathway. ( 28257830 )
2017
29
Neurosurgical Modeling of Retinal Ischemia-Reperfusion Injury. ( 29196198 )
2017
30
Response by Golsari and Thomalla to Letter Regarding Article, &amp;quot;Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study&amp;quot;. ( 28626060 )
2017
31
Thrombolyic and Vasodilator Treatment in a Patient With Prolonged Retinal Ischemia. ( 28471897 )
2017
32
Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats. ( 28523456 )
2017
33
Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia. ( 28636406 )
2017
34
Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents. ( 28335564 )
2017
35
Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model. ( 28878627 )
2017
36
Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In Vitro and Attenuates Retinal Ischemia/Reperfusion Injury In Vivo against Oxidative Stress. ( 28255307 )
2017
37
Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury. ( 28063877 )
2017
38
Utility of optical coherence tomography in the evaluation of monocular visual loss related to retinal ischemia. ( 26765759 )
2016
39
Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. ( 27158842 )
2016
40
The protective effect of prophylactic ozone administration against retinal ischemia-reperfusion injury. ( 27028056 )
2016
41
Peripheral retinal ischemia in a young Indian woman with neurofibromatosis type 1. ( 26949362 )
2016
42
Functional and Structural Evaluation of Sildenafil in a Rat Model of Acute Retinal Ischemia/Reperfusion Injury. ( 27421045 )
2016
43
Pre-treatment with vinpocetine protects against retinal ischemia. ( 27899287 )
2016
44
Involvement of microRNA-181a and Bim in a rat model of retinal ischemia-reperfusion injury. ( 26949607 )
2016
45
Inhibiting Matrix Metalloproteinase 3 Ameliorates Neuronal Loss in the Ganglion Cell Layer of Rats in Retinal Ischemia/Reperfusion. ( 26830289 )
2016
46
Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. ( 26705611 )
2016
47
Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats. ( 27367588 )
2016
48
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury. ( 27008854 )
2016
49
Protective effect of etanercept, an inhibitor of tumor necrosis factor-I+, in a rat model of retinal ischemia. ( 27259948 )
2016
50
Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia. ( 27876485 )
2016

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 BAX CXCL12 HSPB1 NFKB1 TNF VEGFA
2
Show member pathways
13.36 BAX CASP3 CXCL12 HSPB1 NFKB1 TNF
3
Show member pathways
13.25 BAX CASP2 CASP3 CXCL12 NFKB1 TNF
4
Show member pathways
13.09 CAT HIF1A NFKB1 SOD1 VEGFA
5
Show member pathways
12.94 BAX CASP3 NFKB1 TNF VEGFA
6
Show member pathways
12.89 CASP2 CASP3 CXCL12 NFKB1 TNF
7
Show member pathways
12.85 BAX CASP2 CASP3 NFKB1 TNF
8
Show member pathways
12.84 CASP3 CXCL12 NFKB1 TNF VEGFA
9
Show member pathways
12.82 BAX CASP3 NFKB1 PCNA VEGFA
10 12.75 BAX CASP3 CXCL12 HIF1A NFKB1 VEGFA
11
Show member pathways
12.7 BAX CASP2 CASP3 HSPB1 NFKB1 TNF
12
Show member pathways
12.66 BAX CASP2 CASP3 HSPB1 PCNA
13 12.62 CASP2 CASP3 HSPB1 NFKB1 TNF VEGFA
14
Show member pathways
12.55 HSPB1 NFKB1 TNF VEGFA
15
Show member pathways
12.46 CASP2 CASP3 NFKB1 TNF
16
Show member pathways
12.46 CASP2 CASP3 NFKB1 TNF
17 12.39 BAX NFKB1 PCNA TNF
18
Show member pathways
12.31 CAT NFKB1 SOD1 TNF
19 12.27 CASP3 HIF1A TNF VEGFA
20
Show member pathways
12.23 BAX CASP2 CASP3 HIF1A
21 12.21 BAX CASP2 CASP3 TNF
22 12.18 BAX CASP3 NFKB1 TNF
23
Show member pathways
12.15 CASP3 HIF1A NFKB1 VEGFA
24
Show member pathways
12.1 BAX CASP3 NFKB1
25
Show member pathways
12.09 CASP2 CASP3 NFKB1 TNF
26 12.09 BAX CASP3 NFKB1 VEGFA
27
Show member pathways
12.08 BAX CAT NFKB1 SOD1
28 12.05 NFKB1 TNF VEGFA
29 12.05 BAX CASP3 NFKB1 TNF VEGFA
30
Show member pathways
12.01 BAX NFKB1 PCNA
31 12.01 CASP3 HIF1A NFKB1 TNF VEGFA
32
Show member pathways
11.98 BAX CASP2 CASP3 HSPB1 TNF
33 11.97 BAX NFKB1 TNF
34 11.96 BAX CAT NFKB1
35 11.95 HIF1A TNF VEGFA
36 11.93 CASP3 NFKB1 TNF
37 11.89 HIF1A NFKB1 VEGFA
38 11.86 CXCL12 NFKB1 TNF
39 11.85 BAX CASP3 NFKB1
40
Show member pathways
11.84 HIF1A HSPB1 VEGFA
41 11.83 CXCL12 TNF VEGFA
42 11.82 CASP3 HSPB1 NFKB1 TNF
43 11.74 CASP3 NFKB1 TNF
44
Show member pathways
11.74 BAX CASP2 CASP3 NFKB1
45
Show member pathways
11.74 BAX CASP2 CASP3 NFKB1 TNF
46
Show member pathways
11.71 BAX CASP3 CXCL12 NFKB1
47
Show member pathways
11.69 BAX CASP3 HIF1A NFKB1 PCNA TNF
48 11.67 CXCL12 HIF1A VEGFA
49
Show member pathways
11.65 NFKB1 TNF VEGFA
50
Show member pathways
11.61 BAX CASP3 CAT SOD1 TNF

GO Terms for Retinal Ischemia

Cellular components related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CAT CXCL12 HSPB1 KNG1 SOD1 TNF
2 axon cytoplasm GO:1904115 8.8 HIF1A HSPB1 SOD1

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.93 CASP3 HIF1A TNF VEGFA
2 positive regulation of angiogenesis GO:0045766 9.86 HIF1A HSPB1 VEGFA
3 negative regulation of gene expression GO:0010629 9.86 HIF1A NFKB1 TNF VEGFA
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 CAT NFKB1 TNF
5 negative regulation of neuron apoptotic process GO:0043524 9.84 BAX HIF1A SOD1
6 response to oxidative stress GO:0006979 9.83 CAT PCNA SOD1
7 platelet degranulation GO:0002576 9.83 KNG1 SOD1 VEGFA
8 response to virus GO:0009615 9.82 CXCL12 HSPB1 TNF
9 kidney development GO:0001822 9.81 BAX CAT VEGFA
10 response to estradiol GO:0032355 9.8 CASP3 CAT PCNA
11 response to organic substance GO:0010033 9.79 CASP3 SOD1 TNF
12 positive regulation of endothelial cell proliferation GO:0001938 9.76 CXCL12 HIF1A VEGFA
13 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.72 BAX CASP2 PCNA
14 dopaminergic neuron differentiation GO:0071542 9.69 HIF1A VEGFA
15 positive regulation of protein complex assembly GO:0031334 9.69 TNF VEGFA
16 response to hydrogen peroxide GO:0042542 9.69 CASP3 CAT SOD1
17 negative regulation of apoptotic signaling pathway GO:2001234 9.68 BAX HSPB1
18 B cell homeostasis GO:0001782 9.68 BAX CASP3
19 camera-type eye morphogenesis GO:0048593 9.68 HIF1A VEGFA
20 positive regulation of neuroblast proliferation GO:0002052 9.67 HIF1A VEGFA
21 positive regulation of chemokine production GO:0032722 9.67 HIF1A TNF
22 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.67 BAX CASP2 TNF
23 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.66 HIF1A VEGFA
24 muscle cell cellular homeostasis GO:0046716 9.66 HIF1A SOD1
25 positive regulation of blood vessel endothelial cell migration GO:0043536 9.65 HIF1A HSPB1 VEGFA
26 induction of positive chemotaxis GO:0050930 9.64 CXCL12 VEGFA
27 response to reactive oxygen species GO:0000302 9.63 CAT SOD1
28 positive regulation of cell adhesion GO:0045785 9.63 CXCL12 TNF VEGFA
29 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.62 BAX CASP2 CASP3 TNF
30 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.61 BAX CASP3
31 myeloid cell homeostasis GO:0002262 9.61 BAX SOD1
32 positive regulation of neuron apoptotic process GO:0043525 9.61 BAX CASP2 CASP3
33 response to salt stress GO:0009651 9.6 BAX TNF
34 cellular response to nicotine GO:0071316 9.59 NFKB1 TNF
35 ectopic germ cell programmed cell death GO:0035234 9.58 BAX CASP2
36 ovarian follicle development GO:0001541 9.58 BAX SOD1 VEGFA
37 positive regulation of axon extension involved in axon guidance GO:0048842 9.57 CXCL12 VEGFA
38 apoptotic signaling pathway GO:0097190 9.56 BAX CASP2 CASP3 TNF
39 response to hypoxia GO:0001666 9.55 CASP3 CAT CXCL12 HIF1A VEGFA
40 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.54 HIF1A VEGFA
41 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.54 BAX CASP2 CASP3
42 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.52 HSPB1 VEGFA
43 positive regulation of apoptotic process GO:0043065 9.43 BAX CASP2 CASP3 KNG1 SOD1 TNF
44 negative regulation of apoptotic process GO:0043066 9.23 CASP2 CASP3 CAT HIF1A HSPB1 NFKB1

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.63 BAX CAT HSPB1 NFKB1 SOD1 VEGFA
2 enzyme binding GO:0019899 9.35 CASP2 CAT HIF1A PCNA SOD1
3 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.32 CASP2 CASP3
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.26 CASP2 CASP3
5 identical protein binding GO:0042802 9.23 BAX CASP2 HSPB1 NFKB1 PCNA SOD1
6 protein binding GO:0005515 10.18 BAX CASP2 CASP3 CAT HIF1A HSPB1

Sources for Retinal Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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