MCID: RTN003
MIFTS: 48

Retinal Ischemia

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 12 54 15 37 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12510
ICD9CM 34 362.84
SNOMED-CT 67 193427006
ICD10 32 H35.82
UMLS 70 C0162291

Summaries for Retinal Ischemia

Disease Ontology : 12 An ischemia that is characterized by restriction in blood supply to the retina.

MalaCards based summary : Retinal Ischemia is related to exudative vitreoretinopathy 1 and microvascular complications of diabetes 5. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include retina, endothelial and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 exudative vitreoretinopathy 1 31.2 VEGFA TNF HIF1A CRYAA BDNF
2 microvascular complications of diabetes 5 30.9 VEGFA HIF1A CXCL12 CRYAA
3 retinal vein occlusion 30.9 VEGFA TNF CXCL12
4 macular retinal edema 30.5 VEGFA TNF CXCL12 CRYAA
5 ischemia 30.5 VEGFA SOD1 KNG1 HSPB1 HSPA4 HIF1A
6 retinal vascular disease 30.4 VEGFA TXN TNF HIF1A CRYAA CASP3
7 eales disease 30.1 VEGFA TNF SOD1
8 vascular disease 30.0 VEGFA TNF SOD1 KNG1 HSPA4 CXCL12
9 intraocular pressure quantitative trait locus 29.9 VEGFA POU4F1 HSPB1 CRYAA
10 microvascular complications of diabetes 1 29.9 VEGFA TNF IGFBP2 HIF1A CXCL12 CRYAA
11 endophthalmitis 29.9 VEGFA TNF CRYAA
12 ocular hypertension 29.8 TXN POU4F1 CXCL12 CRYAA
13 stroke, ischemic 29.8 TNF HSPA4 CXCL12 CASP3 BDNF
14 nonarteritic anterior ischemic optic neuropathy 29.7 VEGFA POU4F1 CASP2
15 myeloma, multiple 29.7 VEGFA TNF HIF1A CXCL12 CASP3 BCL2L1
16 optic nerve disease 29.6 VEGFA TNF POU4F1 CRYAA BDNF
17 macular degeneration, age-related, 1 29.4 VEGFA TNF POU4F1 HIF1A CRYAA CASP3
18 eye disease 29.3 VEGFA TNF IGFBP2 HSPB1 CRYAA CASP3
19 cataract 29.3 VEGFA TXN TNF SOD1 HSPB1 HIF1A
20 glaucoma, primary open angle 29.1 VEGFA POU4F1 CRYAA BDNF
21 open-angle glaucoma 29.1 VEGFA TNF SOD1 HSPB1 CRYAA BDNF
22 neuroblastoma 28.6 VEGFA TNF SOD1 KNG1 HSPA4 HIF1A
23 exudative vitreoretinopathy 2, x-linked 11.0
24 exudative vitreoretinopathy 4 11.0
25 exudative vitreoretinopathy 3 11.0
26 branch retinal artery occlusion 10.4
27 retinal artery occlusion 10.4
28 yemenite deaf-blind hypopigmentation syndrome 10.4
29 retinal disease 10.4
30 kashin-beck disease 10.4 TNF BAX
31 bursitis 10.4 TNF KNG1 CXCL12
32 dystrophinopathies 10.3 TNF CASP2 APAF1
33 intravascular papillary endothelial hyperplasia 10.3 VEGFA HIF1A
34 oral lichen planus 10.3 HSPA4 CASP3 BAX
35 spotted fever 10.3 TNF CASP3 BAX
36 progressive multifocal leukoencephalopathy 10.3 TNF HIF1A BAX
37 central retinal artery occlusion 10.3
38 absolute glaucoma 10.3 BCL2L1 BAX BAK1
39 retinal degeneration 10.3
40 posterior scleritis 10.3 VEGFA TNF
41 soft tissue sarcoma 10.3 VEGFA TNF HIF1A
42 aids dementia complex 10.3 TNF CXCL12
43 varicocele 10.3 TNF SOD1 HIF1A CASP3
44 pulmonary edema 10.3 TNF KNG1 HIF1A
45 apnea, obstructive sleep 10.3 VEGFA TNF HIF1A
46 oral submucous fibrosis 10.3 VEGFA TNF HIF1A
47 ulcer of lower limbs 10.2 VEGFA TNF
48 colon adenoma 10.2 VEGFA HIF1A CASP3
49 amaurosis fugax 10.2
50 osteonecrosis 10.2 VEGFA TNF HIF1A

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 APAF1 BCL2L1 CASP3 HIF1A SOD1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 APAF1 BAX BCL2L1 CASP3 HIF1A SOD1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.5 BAX HIF1A

MGI Mouse Phenotypes related to Retinal Ischemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 APAF1 BAK1 BAX BCL2L1 BDNF CASP2
2 behavior/neurological MP:0005386 10.37 APAF1 BAK1 BAX BCL2L1 BDNF CASP3
3 mortality/aging MP:0010768 10.31 APAF1 BAK1 BAX BCL2L1 BDNF CASP2
4 immune system MP:0005387 10.3 APAF1 BAK1 BAX BCL2L1 CASP2 CASP3
5 hematopoietic system MP:0005397 10.29 BAK1 BAX BCL2L1 CASP2 CASP3 CXCL12
6 endocrine/exocrine gland MP:0005379 10.27 APAF1 BAK1 BAX BCL2L1 BDNF CASP2
7 nervous system MP:0003631 10.2 APAF1 BAK1 BAX BCL2L1 BDNF CASP2
8 neoplasm MP:0002006 10.02 APAF1 BAK1 BAX BCL2L1 HIF1A SETD2
9 limbs/digits/tail MP:0005371 9.98 APAF1 BAK1 BAX HIF1A SETD2 TNF
10 normal MP:0002873 9.81 APAF1 BAK1 BDNF CXCL12 HIF1A HSPB1
11 no phenotypic analysis MP:0003012 9.8 BDNF CASP3 CXCL12 HSPB1 POU4F1 TNF
12 reproductive system MP:0005389 9.73 APAF1 BAK1 BAX BCL2L1 BDNF CASP2
13 vision/eye MP:0005391 9.28 APAF1 BAX BDNF CASP3 HIF1A POU4F1

Drugs & Therapeutics for Retinal Ischemia

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Normobaric Nocturnal Hyperoxia Therapy for Treating Ischemic-Related Retinal Conditions Withdrawn NCT03730779 Phase 4 Hyperoxia
2 A Randomized, Active-Controlled, Phase II Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation in Subjects With Radiation Retinopathy (RRR Study). Completed NCT02222610 Phase 2 0.5 mg ranibizumab
3 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
4 Randomized Controlled Trial of Lucentis in the Management of New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
5 Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module Completed NCT03279939
6 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes Completed NCT03906383
7 Developing a Non-invasive Method and Device for Assessing the Degree of Midperipheral Retinal Ischemia in Diabetic Retinopathy. Completed NCT01546766
8 Objective Measurement of Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With a Vascular Endothelial Growth Factor Inhibitor. Completed NCT01360385
9 Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types Recruiting NCT04604002
10 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
11 Multifactorial Risk Stratification in Patients With Ischemic Stroke or Transient Ischemic Attack and Structural, Inflammatory, or Arrhythmogenic Cardiac Disease Active, not recruiting NCT04352790
12 Ultra-wide Fluorescein angiograpHy to Evaluate the Progression of Retinal ischeMia After aflibErcept Injections in patientS With Central Retinal Vein Occlusion in Real Life (HERMES Study) Active, not recruiting NCT02880644
13 Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module Terminated NCT03530449

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 21225138 23000646 19347139 23049424

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

MalaCards organs/tissues related to Retinal Ischemia:

40
Retina, Endothelial, Eye, Brain, Bone Marrow, Bone, Myeloid

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 1637)
# Title Authors PMID Year
1
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. 61 54
20008515 2010
2
Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion. 54 61
19967679 2010
3
Insulin may cause deterioration of proliferative diabetic retinopathy. 54 61
19027244 2009
4
[Effects of recombinant human erythropoietin on hypoxia inducible factor-1alpha expression in the retina of rabbits with acute high intraocular pressure]. 54 61
19246297 2009
5
Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. 54 61
19118700 2009
6
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. 61 54
17591953 2007
7
Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats. 61 54
15728570 2005
8
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 61 54
14633857 2003
9
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. 61 54
11328942 2001
10
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. 61 54
11110038 2000
11
VEGF increases retinal vascular ICAM-1 expression in vivo. 61 54
10393052 1999
12
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. 54 61
9499769 1998
13
Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. 61 54
9285495 1997
14
Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease. 61 54
9046048 1997
15
Analysis of localization of adult T-cell leukemia-derived factor in the transient ischemic rat retina after treatment with OP-1206 alpha-CD, a prostaglandin E1 analogue. 61 54
9010470 1997
16
Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. 61 54
8942877 1996
17
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. 54 61
7479819 1995
18
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. 61 54
7540233 1995
19
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. 54 61
8529097 1995
20
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. 61 54
8206709 1994
21
Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. 61 54
7504689 1993
22
Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway. 61
33522374 2021
23
Lentiviral vector-mediated expression of C3 transferase attenuates retinal ischemia and reperfusion injury in rats. 61
33631175 2021
24
CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury. 61
33771636 2021
25
Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries. 61
33665225 2021
26
Unilateral Retinal Ischemia. 61
33733440 2021
27
Reperfusion of retinal ischemia in retinal occlusive vasculitis with nicotinic acid and infliximab in Adamantiades-Behçet's disease. 61
33615039 2021
28
Microvascular cells: A special focus on heterogeneity of pericytes in Diabetes associated complications. 61
33775914 2021
29
Neovascular glaucoma - A review. 61
33595466 2021
30
Retinal nonperfusion in optical coherence tomography angiography. 61
33453421 2021
31
Site of Origin of the Ophthalmic Artery Influences the Risk for Retinal Versus Cerebral Embolic Events. 61
31985565 2021
32
Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model. 61
33503450 2021
33
Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors. 61
33730305 2021
34
lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis. 61
33687475 2021
35
Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response. 61
32833183 2021
36
Transient Monocular Visual Loss: When Is It an Emergency? 61
33277110 2021
37
Ischemia-induced retinal injury is attenuated by Neurovespina, a peptide from the venom of the social wasp Polybia occidentalis. 61
33370615 2021
38
Rubeosis iridis and macular hemorrhages from multiple Corkscrew retinal vessels in a patient with NF1. 61
33601906 2021
39
Quantification of retinal microvascular parameters by severity of diabetic retinopathy using wide-field swept-source optical coherence tomography angiography. 61
33528650 2021
40
Development of neovascular glaucoma after intraocular surgery in Pierson syndrome. 61
33554690 2021
41
Involvement of the NLRC4 inflammasome in promoting retinal ganglion cell death in an acute glaucoma mouse model. 61
33333046 2021
42
A Stress Syndrome Prototype Reflects Type 3 Diabetes and Ischemic Stroke Risk: The SABPA Study. 61
33670473 2021
43
Mesenchymal Stromal Cells Promote Retinal Vascular Repair by Modulating Sema3E and IL-17A in a Model of Ischemic Retinopathy. 61
33553187 2021
44
Occlusive retinal vasculopathy with macular branch retinal artery occlusion as a leading sign of atypical hemolytic uremic syndrome - a case report. 61
33516177 2021
45
Using retinal function to define ischemic exclusion criteria for animal models of glaucoma. 61
33171192 2021
46
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE. 61
29474222 2021
47
The Retrobulbar Spot Sign and Prominent Middle Limiting Membrane as Prognostic Markers in Non-Arteritic Retinal Artery Occlusion. 61
33477523 2021
48
Intravitreal ketamine promotes neuroprotection in rat eyes after experimental ischemia. 61
33249278 2021
49
Application of Hydrogen in Ophthalmology. 61
33076799 2021
50
Macular Microvascular Changes and Their Correlation With Peripheral Nonperfusion in Branch Retinal Vein Occlusion. 61
33412121 2021

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 TNF CXCL12 CASP3 CASP2 BDNF BCL2L1
2
Show member pathways
13.85 VEGFA TNF HIF1A CXCL12 CASP3 BDNF
3
Show member pathways
13.46 TNF SOD1 CASP3 BDNF BCL2L1 BAX
4
Show member pathways
13.21 TNF KNG1 HSPA4 CASP3 BCL2L1 BAX
5
Show member pathways
13.08 VEGFA TXN TNF CASP3 CASP2 BCL2L1
6
Show member pathways
13 VEGFA TNF CASP3 BDNF BCL2L1 BAX
7
Show member pathways
12.93 VEGFA TNF HIF1A CXCL12 CASP3 BCL2L1
8
Show member pathways
12.88 VEGFA TNF HSPA4 CXCL12 CASP3 APAF1
9
Show member pathways
12.85 TNF CASP3 BCL2L1 BAX BAK1 APAF1
10
Show member pathways
12.85 TXN TNF SOD1 CASP3 BCL2L1 BAX
11 12.83 TNF CASP3 BCL2L1 BAX BAK1 APAF1
12 12.79 VEGFA TNF HSPB1 CASP3 CASP2 BDNF
13
Show member pathways
12.75 TXN TNF CASP3 BAX BAK1
14
Show member pathways
12.72 CASP3 BDNF BCL2L1 BAX APAF1
15
Show member pathways
12.72 HSPB1 HSPA4 CASP3 CASP2 BAX APAF1
16 12.7 VEGFA KNG1 HIF1A CXCL12 CASP3 BCL2L1
17
Show member pathways
12.59 TNF HSPB1 CASP3 CASP2 BCL2L1 BAX
18
Show member pathways
12.38 CASP3 BCL2L1 BAX APAF1
19 12.31 VEGFA TNF HIF1A CASP3
20 12.24 TNF CASP3 BAX APAF1
21
Show member pathways
12.24 HIF1A CASP3 CASP2 BCL2L1 BAX BAK1
22 12.21 VEGFA TNF CASP3 BCL2L1 BAX
23 12.2 VEGFA TNF HIF1A CASP3 BDNF
24 12.17 VEGFA CASP3 BAX BAK1
25
Show member pathways
12.14 TNF HSPB1 CASP3 CASP2 BAX APAF1
26 12.09 POU4F1 BAX BAK1 APAF1
27
Show member pathways
12.06 TNF CASP3 CASP2 BAX
28
Show member pathways
12.05 CASP3 BCL2L1 BAX BAK1 APAF1
29 12.02 TXN TNF CASP3 CASP2 BCL2L1 BAX
30 12.01 VEGFA TNF HIF1A BCL2L1
31 11.95 VEGFA TNF CASP3 BAX
32 11.87 CASP3 BCL2L1 BAX BAK1 APAF1
33 11.86 VEGFA TNF CXCL12
34
Show member pathways
11.86 VEGFA HSPB1 HIF1A
35
Show member pathways
11.85 CXCL12 CASP3 BAX APAF1
36 11.82 TXN BCL2L1 BAX BAK1
37 11.81 CASP3 CASP2 APAF1
38
Show member pathways
11.7 CASP3 BDNF APAF1
39 11.7 SOD1 HIF1A CASP3
40 11.69 CASP3 BCL2L1 BAX BAK1 APAF1
41 11.68 VEGFA HIF1A CXCL12
42
Show member pathways
11.65 CASP3 CASP2 BCL2L1 BAX BAK1 APAF1
43 11.62 TNF CASP3 APAF1
44 11.58 TNF BCL2L1 BAX BAK1
45 11.58 VEGFA HIF1A CASP3 BCL2L1
46
Show member pathways
11.46 BCL2L1 BAX BAK1 APAF1
47 11.36 KNG1 CASP3 BAX
48 11.34 TNF CASP3 BCL2L1 BAX
49 11.18 SOD1 CASP3 BCL2L1 BAX

GO Terms for Retinal Ischemia

Cellular components related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.21 TXN SOD1 SETD2 POU4F1 HSPB1 HSPA4
2 extracellular region GO:0005576 10.06 VEGFA TXN TNF SOD1 KNG1 IGFBP2
3 extracellular space GO:0005615 10.03 VEGFA TNF SOD1 KNG1 IGFBP2 HSPB1
4 cytoplasm GO:0005737 10.03 VEGFA TXN SOD1 POU4F1 HSPB1 HSPA4
5 extracellular exosome GO:0070062 9.97 TXN SOD1 KNG1 IGFBP2 HSPB1 HSPA4
6 pore complex GO:0046930 9.46 BAX BAK1
7 axon cytoplasm GO:1904115 9.43 SOD1 HSPB1 HIF1A
8 BAK complex GO:0097145 8.96 BAX BAK1
9 Bcl-2 family protein complex GO:0097136 8.8 BCL2L1 BAX BAK1

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10.15 CASP3 CASP2 BCL2L1 BAX BAK1 APAF1
2 nervous system development GO:0007399 10.11 VEGFA POU4F1 BDNF BAX APAF1
3 negative regulation of gene expression GO:0010629 10.04 VEGFA TNF POU4F1 HIF1A BAK1
4 cytokine-mediated signaling pathway GO:0019221 10.03 VEGFA TNF HIF1A CASP3 BCL2L1
5 brain development GO:0007420 10.02 CXCL12 CASP2 BAK1 APAF1
6 regulation of apoptotic process GO:0042981 10 CASP2 BCL2L1 BAX BAK1 APAF1
7 aging GO:0007568 9.97 SOD1 IGFBP2 CASP2 BAK1 APAF1
8 response to hypoxia GO:0001666 9.96 VEGFA HIF1A CXCL12 CASP3 APAF1
9 response to virus GO:0009615 9.91 TNF HSPB1 CXCL12 BCL2L1
10 negative regulation of apoptotic process GO:0043066 9.91 VEGFA SOD1 POU4F1 HSPB1 HIF1A CRYAA
11 response to organic substance GO:0010033 9.89 TNF SOD1 CASP3
12 positive regulation of endothelial cell proliferation GO:0001938 9.88 VEGFA HIF1A CXCL12
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 VEGFA TXN TNF BDNF
14 response to glucocorticoid GO:0051384 9.87 TNF IGFBP2 CASP3
15 response to hydrogen peroxide GO:0042542 9.85 SOD1 CASP3 BAK1
16 positive regulation of neuron apoptotic process GO:0043525 9.85 TNF CASP3 CASP2 BAX
17 negative regulation of neuron apoptotic process GO:0043524 9.85 SOD1 POU4F1 HIF1A BDNF BCL2L1 BAX
18 positive regulation of cell adhesion GO:0045785 9.84 VEGFA TNF CXCL12
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.84 VEGFA HSPB1 HIF1A
20 positive regulation of protein complex assembly GO:0031334 9.84 VEGFA TNF BAX BAK1
21 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 TNF CASP2 BAX BAK1 APAF1
22 neuron apoptotic process GO:0051402 9.81 CASP3 BCL2L1 BAX APAF1
23 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.8 BAX BAK1 APAF1
24 ovarian follicle development GO:0001541 9.8 VEGFA SOD1 BCL2L1 BAX
25 response to radiation GO:0009314 9.79 TXN CXCL12 BCL2L1
26 release of cytochrome c from mitochondria GO:0001836 9.77 BCL2L1 BAX BAK1
27 B cell homeostasis GO:0001782 9.76 CASP3 BAX BAK1
28 negative regulation of apoptotic signaling pathway GO:2001234 9.76 TNF HSPB1 BDNF BAX
29 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.72 BAX BAK1
30 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.72 TNF CASP2 BCL2L1 BAX BAK1
31 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 9.71 BAX BAK1
32 vagina development GO:0060068 9.71 BAX BAK1
33 regulation of mitochondrial membrane permeability GO:0046902 9.71 BCL2L1 BAK1
34 regulation of mitochondrial membrane potential GO:0051881 9.71 SOD1 BCL2L1 BAX BAK1
35 response to salt stress GO:0009651 9.7 TNF BAX
36 negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 9.7 BAX BAK1
37 myeloid cell homeostasis GO:0002262 9.7 SOD1 BAX BAK1
38 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.69 BAX BAK1
39 B cell apoptotic process GO:0001783 9.69 BAX BAK1
40 positive regulation of axon extension involved in axon guidance GO:0048842 9.69 VEGFA CXCL12
41 vascular endothelial growth factor production GO:0010573 9.68 TNF HIF1A
42 leukocyte homeostasis GO:0001776 9.68 BAX BAK1
43 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.68 VEGFA HIF1A
44 ectopic germ cell programmed cell death GO:0035234 9.67 CASP2 BAX
45 apoptotic process involved in blood vessel morphogenesis GO:1902262 9.66 BAX BAK1
46 positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 9.65 BAX BAK1
47 thymocyte apoptotic process GO:0070242 9.65 BAX BAK1
48 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 VEGFA HSPB1
49 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.65 BAX BAK1 APAF1
50 luteolysis GO:0001554 9.64 CASP3 CASP2

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 VEGFA TXN TNF SOD1 SETD2 POU4F1
2 protein homodimerization activity GO:0042803 9.63 VEGFA TXN HSPB1 BCL2L1 BAX BAK1
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP3 CASP2
4 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.32 CASP3 CASP2
5 identical protein binding GO:0042802 9.32 VEGFA TNF SOD1 HSPB1 CRYAA CASP2
6 BH3 domain binding GO:0051434 9.26 BCL2L1 BAX

Sources for Retinal Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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