MCID: RTN003
MIFTS: 50

Retinal Ischemia

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 12 54 15 37 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12510
ICD9CM 34 362.84
SNOMED-CT 67 26468004
ICD10 32 H35.82
UMLS 71 C0162291

Summaries for Retinal Ischemia

Disease Ontology : 12 An ischemia that is characterized by restriction in blood supply to the retina.

MalaCards based summary : Retinal Ischemia is related to ischemia and retinal vein occlusion. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha), and among its related pathways/superpathways are ERK Signaling and Cellular Senescence (REACTOME). The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, endothelial and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 ischemia 31.1 VEGFA SOD1 KNG1 HSPA4 HIF1A CXCL12
2 retinal vein occlusion 31.0 VEGFA TNF CXCL12
3 microvascular complications of diabetes 5 30.9 VEGFA SOD1 HIF1A CXCL12 CRYAA
4 macular retinal edema 30.8 VEGFA TNF CRYAA
5 microvascular complications of diabetes 1 30.7 VEGFA HIF1A CXCL12
6 retinal vascular disease 30.6 VEGFA TXN TNF HIF1A CRYAA CASP3
7 intraocular pressure quantitative trait locus 30.3 VEGFA POU4F1 HSPB1 CRYAA
8 eales disease 30.2 VEGFA TNF SOD1
9 endophthalmitis 30.1 VEGFA TNF CRYAA
10 optic nerve disease 30.1 VEGFA TNF POU4F1 CRYAA BDNF
11 nonarteritic anterior ischemic optic neuropathy 30.0 VEGFA POU4F1 CASP2
12 stroke, ischemic 29.9 VEGFA TNF HSPA4 CXCL12 CASP3 BDNF
13 ocular hypertension 29.8 TXN POU4F1 CXCL12 CRYAA BDNF
14 vascular disease 29.8 VEGFA TNF SOD1 KNG1 HSPA4 CXCL12
15 macular degeneration, age-related, 1 29.6 VEGFA TNF POU4F1 HIF1A CRYAA CAT
16 myeloma, multiple 29.6 VEGFA TNF HSPA4 HIF1A CXCL12 CASP3
17 eye disease 29.4 VEGFA TNF IGFBP2 HSPB1 HIF1A CRYAA
18 cataract 29.2 VEGFA TXN TNF SOD1 HSPB1 HIF1A
19 neuroblastoma 28.3 VEGFA TNF SOD1 KNG1 HSPA4 HIF1A
20 exudative vitreoretinopathy 1 11.5
21 exudative vitreoretinopathy 2, x-linked 11.2
22 exudative vitreoretinopathy 4 11.2
23 exudative vitreoretinopathy 3 11.2
24 meningitis and encephalitis 10.6 SOD1 CAT
25 lumbosacral lipoma 10.5 TNF SETD2 HIF1A
26 intravascular papillary endothelial hyperplasia 10.5 VEGFA HIF1A
27 indolent b-cell non-hodgkin lymphoma 10.5 BCL2L1 BAX
28 carbuncle 10.5 TNF CAT CASP3
29 kashin-beck disease 10.5 TNF BAX
30 bursitis 10.5 TNF KNG1 CXCL12
31 erysipelas 10.5 TNF SOD1 CAT
32 absolute glaucoma 10.5 BCL2L1 BAX
33 aids dementia complex 10.5 TNF CXCL12
34 dystrophinopathies 10.5 TNF CASP2 APAF1
35 spotted fever 10.5 TNF CASP3 BAX
36 oral lichen planus 10.4 HSPA4 CASP3 BAX
37 progressive multifocal leukoencephalopathy 10.4 TNF HIF1A BAX
38 apnea, obstructive sleep 10.4 VEGFA TNF HIF1A
39 iron deficiency anemia 10.4 TNF HIF1A CAT
40 tonsillitis 10.4 TNF SOD1 CASP3
41 myocardial stunning 10.4 SOD1 KNG1 CAT
42 parkinson disease, mitochondrial 10.4 BCL2L1 BAX
43 radiation proctitis 10.4 VEGFA TNF
44 renovascular hypertension 10.4 SOD1 KNG1 CAT
45 ocular melanoma 10.4 VEGFA TNF HSPA4
46 diabetic encephalopathy 10.4 CAT CASP3 BDNF
47 colon adenoma 10.4 VEGFA HIF1A CASP3
48 cerebral artery occlusion 10.4 TNF HIF1A BDNF
49 encephalomalacia 10.4 TNF CASP3 BDNF
50 branch retinal artery occlusion 10.4

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 APAF1 BCL2L1 CASP3 HIF1A SOD1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 APAF1 BAX BCL2L1 CASP3 HIF1A SOD1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.5 BAX HIF1A
4 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CASP2 CASP3 CAT TNF

MGI Mouse Phenotypes related to Retinal Ischemia:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 APAF1 BAX BCL2L1 BDNF CASP2 CASP3
2 behavior/neurological MP:0005386 10.35 APAF1 BAX BCL2L1 BDNF CASP3 HIF1A
3 mortality/aging MP:0010768 10.27 APAF1 BAX BCL2L1 BDNF CASP2 CASP3
4 growth/size/body region MP:0005378 10.23 APAF1 BAX BCL2L1 BDNF CASP3 HIF1A
5 cardiovascular system MP:0005385 10.22 APAF1 CASP3 CXCL12 HIF1A HSPB1 IGFBP2
6 endocrine/exocrine gland MP:0005379 10.22 APAF1 BAX BCL2L1 BDNF CASP2 CASP3
7 immune system MP:0005387 10.22 APAF1 BAX BCL2L1 CASP2 CASP3 CXCL12
8 hematopoietic system MP:0005397 10.21 BAX BCL2L1 CASP2 CASP3 CXCL12 HIF1A
9 nervous system MP:0003631 10.1 APAF1 BAX BCL2L1 BDNF CASP2 CASP3
10 craniofacial MP:0005382 10.04 APAF1 BDNF CASP3 HIF1A SETD2 TNF
11 neoplasm MP:0002006 9.97 APAF1 BAX BCL2L1 CAT HIF1A SETD2
12 no phenotypic analysis MP:0003012 9.7 BDNF CASP3 CXCL12 HSPB1 POU4F1 TNF
13 reproductive system MP:0005389 9.7 APAF1 BAX BCL2L1 BDNF CASP2 CASP3
14 vision/eye MP:0005391 9.28 APAF1 BAX BDNF CASP3 HIF1A POU4F1

Drugs & Therapeutics for Retinal Ischemia

Drugs for Retinal Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Antineoplastic Agents, Immunological Phase 4
4
Clopidogrel Approved Phase 2, Phase 3 113665-84-2, 120202-66-6 60606
5
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
6
Zinc Approved, Investigational Phase 2, Phase 3 7440-66-6 32051
7
Insulin aspart Approved Phase 2, Phase 3 116094-23-6 16132418
8 Platelet Aggregation Inhibitors Phase 2, Phase 3
9 Analgesics, Non-Narcotic Phase 2, Phase 3
10 Fibrinolytic Agents Phase 2, Phase 3
11 Purinergic P2Y Receptor Antagonists Phase 2, Phase 3
12 Cyclooxygenase Inhibitors Phase 2, Phase 3
13 Analgesics Phase 2, Phase 3
14 Antipyretics Phase 2, Phase 3
15 Antirheumatic Agents Phase 2, Phase 3
16 Anti-Inflammatory Agents Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
19 Hypoglycemic Agents Phase 2, Phase 3
20 insulin Phase 2, Phase 3
21 Insulin, Globin Zinc Phase 2, Phase 3
22
Hydroxyurea Approved Phase 2 127-07-1 3657
23
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
24
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
25
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
26
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
27
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
28 Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
29
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
30 Hormones Phase 1, Phase 2
31 Triamcinolone diacetate Phase 2
32 Hormone Antagonists Phase 1, Phase 2
33 Triamcinolone hexacetonide Phase 2
34 triamcinolone acetonide Phase 2
35 glucocorticoids Phase 1, Phase 2
36 Gastrointestinal Agents Phase 1, Phase 2
37 Methylprednisolone Acetate Phase 1, Phase 2
38 Hematinics Phase 1, Phase 2
39 Antineoplastic Agents, Hormonal Phase 1, Phase 2
40 Antiemetics Phase 1, Phase 2
41 Epoetin alfa Phase 1, Phase 2 113427-24-0
42 Neuroprotective Agents Phase 1, Phase 2
43 Protective Agents Phase 1, Phase 2
44 Immunologic Factors Phase 2
45 Immunosuppressive Agents Phase 2
46
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
47
Sevoflurane Approved, Vet_approved 28523-86-6 5206
48 Anesthetics
49 Hypnotics and Sedatives
50 Anesthetics, General

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 The Effect of Bevacizumab on Peripheral Retinal Changes as Imaged by Wide -Field Fluorescein Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
2 Evaluation of the Effect of Repeated Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using Optical Coherence Tomography Angiography Completed NCT03246152 Phase 4 Bevacizumab
3 Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Macular Edema in Subjects Who Completed the Three Year VISTA-DME Trial . Completed NCT02299336 Phase 4 Aflibercept
4 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion: the PLATON Trial Recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
5 Different Regimens of Ranibizumab Treatment for Macular Edema Secondary to Retinal Vein Occlusion: a Randomized and Controlled Clinical Study. Not yet recruiting NCT04062370 Phase 4 Ranibizumab
6 Normobaric Nocturnal Hyperoxia Therapy for Treating Ischemic-Related Retinal Conditions Withdrawn NCT03730779 Phase 4 Hyperoxia
7 Central Vein Occlusion Study (CVOS) Completed NCT00000131 Phase 3
8 Study of COmparative Treatments for REtinal Vein Occlusion 2 [SCORE2]: a Multicenter, Prospective, Randomized Non-inferiority Trial of Eyes With Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Every 4 Weeks With Intravitreal Aflibercept Every 4 Weeks. Active, not recruiting NCT01969708 Phase 3 aflibercept;bevacizumab
9 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Active, not recruiting NCT01758614 Phase 3 Aspirin;Clopidogrel
10 Phase III Study of Pharos Vitesse Neurovascular Stent System Compared to Best Medical Therapy for the Treatment of Ischemic Disease Terminated NCT00816166 Phase 2, Phase 3 Aspirin and Clopidogrel (Medical therapy)
11 Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Terminated NCT00991029 Phase 3 Clopidogrel;placebo
12 Effects of Pulsatile IV Insulin Delivery on Diabetic Retinopathy Terminated NCT00287651 Phase 2, Phase 3
13 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Unknown status NCT02957760 Phase 2 Hydroxycarbamid
14 The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Patients With Diabetic Retinopathy Unknown status NCT03006081 Phase 2 Intravitreal Aflibercept injection
15 Intravitreal Avastin Versus Intravitreal Avastin and Triamcinolone in Central Retinal Vein Occlusion(CRVO) Unknown status NCT00370630 Phase 2 Avastin (Bevacizumab) and triamcinolone
16 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
17 Phase 2 Study of Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy. Completed NCT02151695 Phase 2 Aflibercept intravitreal injections
18 A Randomized, Active-Controlled, Phase II Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation in Subjects With Radiation Retinopathy (RRR Study). Completed NCT02222610 Phase 2 0.5 mg ranibizumab
19 Study of Visual Recovery After Erythropoietin (EPO) Injection, in Patients With Traumatic Optic Neuropathy (TON) Completed NCT01783847 Phase 1, Phase 2 Recombinant human erythropoietin (EPO);Methyl prednisolone
20 Ranibizumab (rhuFab V2) and Scatter Laser Photocoagulation in Treatment of Patients With Clinically-significant Diabetic Macular Edema With Peripheral Retinal Nonperfusion (RaScaL) Completed NCT00815360 Phase 2 intravitreal injection of ranibizumab;intravitreal injection of triamcinolone acetonide
21 Phase I/II Randomized, Prospective, Double-masked, Sham-controlled Study of Intravitreal Autologous Bone Marrow CD34+ Stem Cell Therapy for Central Retinal Vein Occlusion Recruiting NCT03981549 Phase 1, Phase 2
22 Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy Active, not recruiting NCT02863354 Phase 2 Aflibercept
23 Randomized Controlled Trial of Lucentis in the Management of New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
24 Correlation Between Retinal Metabolism and the Observation of a Visible Retinal Spontaneous Venous Pulse Unknown status NCT01794442
25 Objective Measurement of Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With a Vascular Endothelial Growth Factor Inhibitor. Completed NCT01360385
26 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes Completed NCT03906383
27 The Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
28 Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module Completed NCT03279939
29 Prevalence and Characterization of Retinopathy in Children With Type 1 Diabetes Using a Non-mydriatic Fundus Camera Completed NCT02691312
30 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
31 Developing a Non-invasive Method and Device for Assessing the Degree of Midperipheral Retinal Ischemia in Diabetic Retinopathy. Completed NCT01546766
32 Costs and Outcomes of an Emergency Department-based Accelerated Diagnostic Protocol vs Hospitalization for Patients With Transient Ischemic Attack: a Randomized Controlled Trial. Completed NCT00321022
33 Short Term Ocular Safety Assessment of High Dose Omega-3 Supplementation for Age-Related Macular Degeneration. Completed NCT01258335
34 Triple Procedure for Dense Cataractus Neovascular Glaucoma Patients Completed NCT04143620
35 Pilot Study OCT of Retinal Blood Flow in Proliferative Diabetic Retinopathy Before and After Panretinal Photocoagulation Completed NCT01928550
36 The Individually-Marked Panretinal Laser phoTocoagulation for Proliferative Diabetic Retinopathy Study: IMPETUS 2018 - TREAT Completed NCT03113006
37 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
38 Ultra-wide Fluorescein angiograpHy to Evaluate the Progression of Retinal ischeMia After aflibErcept Injections in patientS With Central Retinal Vein Occlusion in Real Life (HERMES Study) Recruiting NCT02880644
39 Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy Recruiting NCT03922932
40 Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes Active, not recruiting NCT02876744
41 Multifactorial Risk Stratification in Patients With Ischemic Stroke or Transient Ischemic Attack and Structural, Inflammatory, or Arrhythmogenic Cardiac Disease Active, not recruiting NCT04352790
42 Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module Terminated NCT03530449

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 21225138 23000646 19347139 23049424

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

MalaCards organs/tissues related to Retinal Ischemia:

40
Retina, Endothelial, Eye, Bone, Brain, Bone Marrow, T Cells

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 1557)
# Title Authors PMID Year
1
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. 54 61
20008515 2010
2
Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion. 61 54
19967679 2010
3
Insulin may cause deterioration of proliferative diabetic retinopathy. 61 54
19027244 2009
4
[Effects of recombinant human erythropoietin on hypoxia inducible factor-1alpha expression in the retina of rabbits with acute high intraocular pressure]. 61 54
19246297 2009
5
Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. 61 54
19118700 2009
6
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. 61 54
17591953 2007
7
Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats. 61 54
15728570 2005
8
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 61 54
14633857 2003
9
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. 61 54
11328942 2001
10
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. 61 54
11110038 2000
11
VEGF increases retinal vascular ICAM-1 expression in vivo. 54 61
10393052 1999
12
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. 61 54
9499769 1998
13
Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. 54 61
9285495 1997
14
Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease. 61 54
9046048 1997
15
Analysis of localization of adult T-cell leukemia-derived factor in the transient ischemic rat retina after treatment with OP-1206 alpha-CD, a prostaglandin E1 analogue. 54 61
9010470 1997
16
Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. 61 54
8942877 1996
17
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. 54 61
7479819 1995
18
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. 54 61
7540233 1995
19
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. 61 54
8529097 1995
20
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. 54 61
8206709 1994
21
Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. 54 61
7504689 1993
22
Light-Induced Amaurosis-A Case Report and Brief Literature Review. 61
32027984 2020
23
SEVERITY OF DIABETIC MACULAR EDEMA CORRELATES WITH RETINAL VASCULAR BED AREA ON ULTRA-WIDE FIELD FLUORESCEIN ANGIOGRAPHY: DAVE Study. 61
31356494 2020
24
Normal to supernormal 30-Hz flicker ERGs predict visual function and prognosis in central retinal artery occlusion. 61
32506269 2020
25
IMPACT OF RETINAL ISCHEMIA ON FUNCTIONAL AND ANATOMICAL OUTCOMES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN PATIENTS WITH RETINAL VEIN OCCLUSION. 61
31157714 2020
26
ACUTE RETINAL ISCHEMIA IN CENTRAL VERSUS BRANCH RETINAL ARTERY OCCLUSION: Changes in Retinal Layers' Thickness on Spectral-Domain Optical Coherence Tomography in Different Grades of Retinal Ischemia. 61
30908470 2020
27
scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries. 61
32382585 2020
28
Two cases of severe Purtscher-like retinopathy demonstrating recurrence and progression to neovascularization and vitreous hemorrhage. 61
32211564 2020
29
Spectrum of peripheral retinal ischemia in Wyburn-Mason syndrome. 61
32181415 2020
30
Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy. 61
31823871 2020
31
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome. 61
32526286 2020
32
All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion. 61
32492112 2020
33
Experimental evidence for the involvement of F0/F1 ATPase and subsequent P2Y12 receptor activation in prothymosin alpha-induced protection of retinal ischemic damage. 61
32156464 2020
34
Control of retinal blood flow levels by selected combinations of cervical arterial ligations in rat. 61
32502531 2020
35
Intravitreal conbercept for branch retinal vein occlusion induced macular edema: one initial injection versus three monthly injections. 61
32527234 2020
36
Successful treatment of ciliary body medulloepithelioma with intraocular melphalan chemotherapy: a case report. 61
32552699 2020
37
Huoxue-Tongluo-Lishui-Decoction is visual-protective against retinal ischemia-reperfusion injury. 61
32070875 2020
38
Magnesium acetyltaurate protects against endothelin-1 induced RGC loss by reducing neuroinflammation in Sprague dawley rats. 61
32156652 2020
39
Novel Cell-Based and Tissue Engineering Approaches for Induction of Angiogenesis as an Alternative Therapy for Diabetic Retinopathy. 61
32429094 2020
40
Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia. 61
31583505 2020
41
Spontaneous Necrosis of a Large Choroidal Melanoma: Unusual Presentation in a 49-Year-Old Male. 61
32509762 2020
42
Autophagy and post-ischemic conditioning in retinal ischemia. 61
32452260 2020
43
p38 promoted retinal micro-angiogenesis through up-regulated RUNX1 expression in diabetic retinopathy. 61
32319515 2020
44
One-year follow-up of ischemic index changes after intravitreal dexamethasone implant for diabetic macular edema: an ultra-widefield fluorescein angiography study. 61
31749052 2020
45
Ribonuclease attenuates retinal ischemia reperfusion injury through inhibition of inflammatory response and apoptosis in mice. 61
32447222 2020
46
Regional Expression of Act-MMP3 Contributes to the Selective Loss of Neurons in Ganglion Cell Layers following Acute Retinal ischemia/Reperfusion Injury. 61
31661993 2020
47
Blocking endothelial apoptosis revascularises the retina in a model of ischemic retinopathy. 61
32427589 2020
48
Epigallocatechin 3-Gallate Has a Neuroprotective Effect in Retinas of Rabbits with Ischemia/Reperfusion through the Activation of Nrf2/HO-1. 61
32466215 2020
49
Ranibizumab Pro Re nata versus Dexamethasone in the Management of Ischemic Retinal Vein Occlusion: Post-hoc Analysis from the COMRADE Trials. 61
31665935 2020
50
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury. 61
31912273 2020

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 VEGFA TNF HIF1A CXCL12 CASP3 BDNF
2
Show member pathways
13.13 VEGFA TXN SOD1 HSPA4 HIF1A CAT
3
Show member pathways
13.09 TXN TNF SOD1 CASP3 BDNF BCL2L1
4
Show member pathways
13.01 VEGFA TXN TNF CASP3 CASP2 BCL2L1
5
Show member pathways
12.96 VEGFA TNF CASP3 BDNF BCL2L1 BAX
6
Show member pathways
12.9 VEGFA TNF HIF1A CXCL12 CASP3 BCL2L1
7
Show member pathways
12.84 VEGFA TNF HSPA4 CXCL12 CASP3 APAF1
8
Show member pathways
12.81 TNF CASP3 BCL2L1 BAX APAF1
9 12.78 TNF CASP3 BCL2L1 BAX APAF1
10 12.75 VEGFA TNF HSPB1 CASP3 CASP2 BDNF
11
Show member pathways
12.69 CASP3 BDNF BCL2L1 BAX APAF1
12
Show member pathways
12.68 HSPB1 HSPA4 CASP3 CASP2 BAX APAF1
13 12.65 VEGFA KNG1 HIF1A CXCL12 CASP3 BCL2L1
14
Show member pathways
12.62 TNF HSPB1 CASP3 CASP2 BCL2L1 BAX
15
Show member pathways
12.36 CASP3 BCL2L1 BAX APAF1
16
Show member pathways
12.32 TXN TNF SOD1 CAT
17 12.28 TXN TNF CASP3 BAX
18 12.28 VEGFA TNF HIF1A CASP3
19
Show member pathways
12.22 HIF1A CASP3 CASP2 BCL2L1 BAX
20 12.21 TNF CASP3 BAX APAF1
21 12.13 VEGFA TNF CASP3 BCL2L1 BAX
22 12.1 VEGFA TNF HIF1A CASP3 BDNF
23
Show member pathways
12.03 CASP3 BCL2L1 BAX APAF1
24
Show member pathways
12.02 TNF CASP3 CASP2 BAX
25
Show member pathways
11.99 TNF HSPB1 CASP3 CASP2 BAX APAF1
26 11.98 VEGFA TNF HIF1A BCL2L1
27 11.91 VEGFA TNF CASP3 BAX
28 11.86 VEGFA TNF CXCL12
29
Show member pathways
11.85 VEGFA HSPB1 HIF1A
30 11.85 CASP3 BCL2L1 BAX APAF1
31 11.81 CASP3 CASP2 APAF1
32
Show member pathways
11.79 CXCL12 CASP3 BAX APAF1
33 11.77 TXN BCL2L1 BAX
34 11.77 TXN TNF CASP3 CASP2 BCL2L1 BAX
35 11.73 CASP3 BCL2L1 BAX APAF1
36
Show member pathways
11.72 CASP3 CASP2 BCL2L1 BAX APAF1
37
Show member pathways
11.67 CASP3 BDNF APAF1
38 11.67 SOD1 HIF1A CASP3
39 11.66 VEGFA HIF1A CXCL12
40 11.59 TNF CASP3 APAF1
41
Show member pathways
11.57 TXN SOD1 CAT
42 11.53 TNF BCL2L1 BAX
43 11.49 VEGFA HIF1A CASP3 BCL2L1
44
Show member pathways
11.42 BCL2L1 BAX APAF1
45 11.33 KNG1 CASP3 BAX
46 11.24 TNF CASP3 BCL2L1 BAX
47 11.15 TNF SOD1 CAT CASP3 BCL2L1 BAX
48 11.13 CASP3 BCL2L1 BAX
49 11.12 VEGFA IGFBP2 HIF1A BCL2L1 BAX
50 11.07 SOD1 CASP3 BCL2L1 BAX

GO Terms for Retinal Ischemia

Cellular components related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.25 TXN SOD1 SETD2 POU4F1 HSPB1 HSPA4
2 extracellular region GO:0005576 9.96 VEGFA TXN TNF SOD1 KNG1 IGFBP2
3 extracellular space GO:0005615 9.81 VEGFA TNF SOD1 KNG1 IGFBP2 HSPB1
4 extracellular exosome GO:0070062 9.65 TXN SOD1 KNG1 IGFBP2 HSPB1 HSPA4
5 cytoplasm GO:0005737 9.53 VEGFA TXN SOD1 POU4F1 HSPB1 HSPA4
6 axon cytoplasm GO:1904115 9.5 SOD1 HSPB1 HIF1A
7 Bcl-2 family protein complex GO:0097136 9.37 BCL2L1 BAX

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.99 SOD1 IGFBP2 CAT CASP3 BDNF
2 cytokine-mediated signaling pathway GO:0019221 9.98 VEGFA TNF HIF1A CASP3 BCL2L1
3 regulation of apoptotic process GO:0042981 9.97 CASP2 BCL2L1 BAX APAF1
4 aging GO:0007568 9.92 SOD1 IGFBP2 CAT CASP2 APAF1
5 kidney development GO:0001822 9.88 VEGFA CAT BAX APAF1
6 response to virus GO:0009615 9.86 TNF HSPB1 CXCL12 BCL2L1
7 response to organic substance GO:0010033 9.85 TNF SOD1 CASP3
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.85 TNF CASP2 BAX APAF1
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 VEGFA TXN TNF BDNF
10 positive regulation of endothelial cell proliferation GO:0001938 9.83 VEGFA HIF1A CXCL12
11 response to glucocorticoid GO:0051384 9.83 TNF IGFBP2 CASP3
12 response to hydrogen peroxide GO:0042542 9.81 SOD1 CAT CASP3
13 positive regulation of neuron apoptotic process GO:0043525 9.81 TNF CASP3 CASP2 BAX
14 positive regulation of protein complex assembly GO:0031334 9.8 VEGFA TNF BAX
15 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.8 TNF CASP2 BCL2L1 BAX
16 response to hypoxia GO:0001666 9.8 VEGFA HIF1A CXCL12 CAT CASP3 APAF1
17 positive regulation of cell adhesion GO:0045785 9.79 VEGFA TNF CXCL12
18 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 VEGFA HSPB1 HIF1A
19 ovarian follicle development GO:0001541 9.78 VEGFA SOD1 BCL2L1 BAX
20 neuron apoptotic process GO:0051402 9.76 CASP3 BCL2L1 BAX APAF1
21 regulation of mitochondrial membrane potential GO:0051881 9.74 SOD1 BCL2L1 BAX
22 response to radiation GO:0009314 9.73 TXN CXCL12 CAT BCL2L1
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.71 CASP3 CASP2 BCL2L1 BAX
24 negative regulation of apoptotic signaling pathway GO:2001234 9.67 TNF HSPB1 BDNF BAX
25 response to salt stress GO:0009651 9.66 TNF BAX
26 myeloid cell homeostasis GO:0002262 9.65 SOD1 BAX
27 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.65 BAX APAF1
28 apoptotic signaling pathway GO:0097190 9.65 TNF CASP3 CASP2 BAX APAF1
29 positive regulation of axon extension involved in axon guidance GO:0048842 9.64 VEGFA CXCL12
30 ectopic germ cell programmed cell death GO:0035234 9.64 CASP2 BAX
31 negative regulation of neuron apoptotic process GO:0043524 9.63 SOD1 POU4F1 HIF1A BDNF BCL2L1 BAX
32 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.62 VEGFA HIF1A
33 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.61 VEGFA HSPB1
34 luteolysis GO:0001554 9.6 CASP3 CASP2
35 positive regulation of apoptotic process GO:0043065 9.56 TNF SOD1 POU4F1 KNG1 CASP3 CASP2
36 negative regulation of apoptotic process GO:0043066 9.36 VEGFA SOD1 POU4F1 HSPB1 HIF1A CRYAA

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 VEGFA TXN TNF SOD1 SETD2 KNG1
2 protein homodimerization activity GO:0042803 9.43 VEGFA TXN HSPB1 CAT BCL2L1 BAX
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP3 CASP2
4 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.32 CASP3 CASP2
5 identical protein binding GO:0042802 9.32 VEGFA TNF SOD1 HSPB1 CRYAA CAT
6 BH3 domain binding GO:0051434 9.16 BCL2L1 BAX

Sources for Retinal Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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