MCID: RTN005
MIFTS: 25

Retinal Lattice Degeneration

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Lattice Degeneration

MalaCards integrated aliases for Retinal Lattice Degeneration:

Name: Retinal Lattice Degeneration 12 15 71
Palisade Degeneration of Retina 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12165
ICD9CM 34 362.63
SNOMED-CT 67 3577000
ICD10 32 H35.41
UMLS 71 C0154856

Summaries for Retinal Lattice Degeneration

MalaCards based summary : Retinal Lattice Degeneration, also known as palisade degeneration of retina, is related to vitreous syneresis and congenital muscular dystrophy without intellectual disability. An important gene associated with Retinal Lattice Degeneration is CYLC2 (Cylicin 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and O-linked glycosylation. Affiliated tissues include retina, and related phenotypes are embryo and growth/size/body region

Related Diseases for Retinal Lattice Degeneration

Diseases related to Retinal Lattice Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 vitreous syneresis 29.2 SFTA3 CYLC2 CYLC1 COL2A1
2 congenital muscular dystrophy without intellectual disability 10.3 POMT1 FKTN
3 congenital muscular dystrophy with intellectual disability 10.2 POMT2 POMT1
4 congenital muscular dystrophy with cerebellar involvement 10.2 POMT2 POMT1
5 congenital muscular dystrophy-dystroglycanopathy type a2 10.2 POMT2 POMT1
6 retinal perforation 10.2 CYLC2 COL2A1
7 irregular astigmatism 10.2 CYLC1 COL4A4
8 ablepharon-macrostomia syndrome 10.2 POMT1 FKTN
9 regular astigmatism 10.1 DPT CYLC1
10 pectus carinatum 10.1 FBN1 COL2A1
11 intraocular pressure quantitative trait locus 10.0
12 joint laxity, short stature, and myopia 10.0
13 open-angle glaucoma 10.0
14 myopia 10.0
15 muscular dystrophy, congenital, 1b 10.0 FKTN DAG1
16 cardiomyopathy, dilated, 1x 10.0 FKTN DAG1
17 anisometropia 10.0 DPT CYLC1
18 color agnosia 10.0 DAG1 CYLC1
19 cardiomyopathy, dilated, 3b 10.0 FKTN DAG1
20 periventricular nodular heterotopia 10.0 POMT2 POMT1 FKTN
21 tracheal disease 10.0 FBN1 COL2A1
22 autosomal recessive limb-girdle muscular dystrophy type 2a 9.9 FKTN DAG1
23 vitreous detachment 9.9 DPT CYLC1 COL2A1
24 autosomal recessive limb-girdle muscular dystrophy 9.9 POMT1 FKTN DAG1
25 autosomal recessive limb-girdle muscular dystrophy type 2d 9.8 POMT1 FKTN DAG1
26 cardiomyopathy, dilated, 1d 9.8 POMT2 POMT1 DAG1
27 secondary corneal edema 9.8 SFTA3 CYLC1
28 muscular dystrophy, limb-girdle, autosomal recessive 2 9.7 POMT2 POMT1 DAG1
29 exotropia 9.7 FBN1 DPT CYLC1
30 primary congenital glaucoma 9.7 POMT1 FBN1
31 congenital disorder of glycosylation, type in 9.7 POMT2 POMT1 DAG1
32 spherocytosis, type 2 9.6 SFTA3 CYLC1
33 congenital muscular dystrophy-dystroglycanopathy type a 9.6 POMT2 POMT1 FKTN DAG1
34 congenital muscular dystrophy-dystroglycanopathy type a1 9.6 POMT2 POMT1 FKTN DAG1
35 muscular dystrophy-dystroglycanopathy 9.6 POMT2 POMT1 FKTN DAG1
36 autosomal recessive limb-girdle muscular dystrophy type 2l 9.6 POMT2 POMT1 FKTN DAG1
37 muscular dystrophy-dystroglycanopathy , type c, 2 9.6 POMT2 POMT1 FKTN DAG1
38 muscular dystrophy-dystroglycanopathy , type c, 3 9.6 POMT2 POMT1 FKTN DAG1
39 hydrophthalmos 9.6 POMT2 POMT1 FKTN DAG1
40 muscular dystrophy-dystroglycanopathy , type c, 1 9.6 POMT2 POMT1 FKTN DAG1
41 muscular dystrophy-dystroglycanopathy , type b, 6 9.6 POMT2 POMT1 FKTN DAG1
42 cobblestone lissencephaly 9.6 POMT2 POMT1 FKTN DAG1
43 lissencephaly 9.6 POMT2 POMT1 FKTN DAG1
44 muscular dystrophy-dystroglycanopathy , type c, 4 9.6 POMT2 POMT1 FKTN DAG1
45 muscular dystrophy-dystroglycanopathy , type a, 1 9.6 POMT2 POMT1 FKTN DAG1
46 muscular dystrophy-dystroglycanopathy , type b, 5 9.6 POMT2 POMT1 FKTN DAG1
47 muscular dystrophy, congenital merosin-deficient, 1a 9.6 POMT2 POMT1 FKTN DAG1
48 muscular dystrophy-dystroglycanopathy , type c, 5 9.6 POMT2 POMT1 FKTN DAG1
49 muscle eye brain disease 9.6 POMT2 POMT1 FKTN DAG1
50 spherocytosis, type 1 9.6 SFTA3 CYLC1

Graphical network of the top 20 diseases related to Retinal Lattice Degeneration:



Diseases related to Retinal Lattice Degeneration

Symptoms & Phenotypes for Retinal Lattice Degeneration

MGI Mouse Phenotypes related to Retinal Lattice Degeneration:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.5 COL2A1 DAG1 FBN1 FKTN KIF5B POMT1
2 growth/size/body region MP:0005378 9.28 COL2A1 COL4A4 DAG1 DPT FBN1 FKTN

Drugs & Therapeutics for Retinal Lattice Degeneration

Search Clinical Trials , NIH Clinical Center for Retinal Lattice Degeneration

Genetic Tests for Retinal Lattice Degeneration

Anatomical Context for Retinal Lattice Degeneration

MalaCards organs/tissues related to Retinal Lattice Degeneration:

40
Retina

Publications for Retinal Lattice Degeneration

Articles related to Retinal Lattice Degeneration:

(show all 12)
# Title Authors PMID Year
1
Bilateral rhegmatogenous retinal detachment due to unusual retinal degeneration in Down syndrome: A case report. 61
29851814 2018
2
Pars plana vitrectomy compared with pars plana vitrectomy combined with scleral buckle in the primary management of noncomplex rhegmatogenous retinal detachment. 61
24853687 2014
3
Outpatient- and inpatient-based buckling surgery: a comparative study. 61
24812485 2014
4
Accommodative loss after retinal cryotherapy. 61
18834581 2009
5
Dilated examination of patients referred with minor lid complaints--is it necessary? 61
16645629 2007
6
Posterior vitreous detachment and retinal detachment after cataract surgery. 61
17208303 2007
7
Relationship between retinal lattice degeneration and open angle glaucoma. 61
15533618 2005
8
[Bilateral retinal detachment after laser in situ keratomileusis]. 61
15506491 2004
9
Rhegmatogenous retinal detachment and uveitis. 61
12578792 2003
10
Apoptosis in human retinal degenerations. 61
8981707 1996
11
[A study on treatment of retinal detachment with unseen retinal breaks]. 61
2289585 1990
12
[Clinical features and prognosis of retinal lattice degeneration]. 61
2249577 1990

Variations for Retinal Lattice Degeneration

Expression for Retinal Lattice Degeneration

Search GEO for disease gene expression data for Retinal Lattice Degeneration.

Pathways for Retinal Lattice Degeneration

Pathways related to Retinal Lattice Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 FBN1 DAG1 COL4A4 COL2A1
2
Show member pathways
11.7 POMT2 POMT1 DAG1
3
Show member pathways
11.45 FBN1 DAG1 COL4A4 COL2A1
4 10.16 POMT2 POMT1 FKTN

GO Terms for Retinal Lattice Degeneration

Cellular components related to Retinal Lattice Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 SFTA3 FKTN FBN1 DPT DAG1 COL4A4
2 endoplasmic reticulum lumen GO:0005788 9.56 FBN1 DAG1 COL4A4 COL2A1
3 collagen-containing extracellular matrix GO:0062023 9.35 FBN1 DPT DAG1 COL4A4 COL2A1
4 cytoskeletal calyx GO:0033150 9.16 CYLC2 CYLC1
5 basement membrane GO:0005604 8.92 FBN1 DAG1 COL4A4 COL2A1

Biological processes related to Retinal Lattice Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein glycosylation GO:0006486 9.58 POMT2 POMT1 FKTN
2 protein O-linked glycosylation GO:0006493 9.43 POMT2 POMT1 FKTN
3 mannosylation GO:0097502 9.37 POMT2 POMT1
4 extracellular matrix organization GO:0030198 9.35 POMT1 FBN1 DAG1 COL4A4 COL2A1
5 morphogenesis of an epithelial sheet GO:0002011 9.32 MPP5 DAG1
6 positive regulation of protein O-linked glycosylation GO:1904100 9.16 POMT2 POMT1
7 protein O-linked mannosylation GO:0035269 8.8 POMT2 POMT1 FKTN

Molecular functions related to Retinal Lattice Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.26 COL4A4 COL2A1
2 mannosyltransferase activity GO:0000030 9.16 POMT2 POMT1
3 dolichyl-phosphate-mannose-protein mannosyltransferase activity GO:0004169 8.96 POMT2 POMT1
4 extracellular matrix structural constituent GO:0005201 8.92 FBN1 DPT COL4A4 COL2A1

Sources for Retinal Lattice Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....